| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor . ^^^ We have shown that the Ada adaptor complex is important for the gene activation capacity of the glucocorticoid receptor in yeast . ^^^ |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that the Ada adapter proteins are important for glucocorticoid receptor ( GR ) mediated gene activation in yeast . ^^^ The N terminal transactivation domain of GR , tau 1 , is dependent upon Ada 2 , Ada 3 , and Gcn 5 for transactivation in vitro and in vivo . ^^^ Using in vitro techniques , we demonstrate that the GR tau 1 interacts directly with the native Ada containing histone acetyltransferase ( HAT ) complex SAGA but not the related Ada complex . ^^^ |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| We have used yeast genetics and in vitro protein protein interaction experiments to explore the possibility that GCN 5 ( general control nonrepressed protein 5 ) and several other ADA ( alteration / deficiency in activation ) adaptor proteins of the multimeric SAGA complex can regulate T3 / GRIP1 ( glucocorticoid receptor interacting protein 1 ) and SRC 1 ( steroid receptor coactivator 1 ) coactivator dependent activation of transcription by the human T 3 receptor beta 1 ( hTRbeta 1 ) . ^^^ |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| We have shown that yeast mutants with defects in the Ada adaptor proteins are defective in hormone dependent gene activation by ectopically expressed human glucocorticoid receptor ( GR ) . ^^^ Our recent work has focused on determining ( 1 ) which of the Ada containing complexes mediates gene activation by GR , ( 2 ) whether the HAT activity encoded by GCN 5 is required for GR dependent gene activation , ( 3 ) whether the Ada proteins contribute to GR mediated activation at the level of chromatin remodelling and ( 4 ) how the role of these HAT complexes is integrated with other chromatin remodelling activities during GR mediated gene activation . ^^^ |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00813 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
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