Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The cytokine receptor homologous ( CRH ) region of the murine granulocyte colony stimulating factor ( G CSF ) receptor was secreted using a Escherichia coli maltose binding protein ( MBP ) fusion system . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was measured in the serum and CSF of patients with acute cerebrovascular disease ( CVD , 34 cases ) , demyelinating disorders ( DMD , 30 cases ) and other neurological diseases ( OND , 26 cases ) by using a double antibody radioimmunoassay ( RIA ) . ^^^ In CSF , MBP levels in patients with acute CVD and patients with DMD were significantly greater than those in OND patients ( P < 0 . 05 ) . ^^^ The results also show that there was a linear relationship between the CSF MBP levels and the serum MBP levels in patients with acute CVD ( r = 0 . 72 , P < 0 . 01 ) , but no such relationship in patients with DMD and OND . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was measured in cerebrospinal fluid ( CSF ) of patients with acquired immunodeficiency syndrome ( AIDS ) dementia complex ( ADC ) in order to investigate the degree of white matter destruction . ^^^ Results show that increased CSF levels of MBP were detected in all patients with severe ADC ( 10 / 10 ) and , less often , in subjects with mild ( 2 / 7 ) or moderate dementia ( 7 / 16 ) . ^^^ Our findings suggest that the measurement of CSF MBP concentration may represent a predictive marker of myelin injury and neurologic damage during the course of ADC . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A correlative triad of gadolinium DTPA MRI , EDSS , and CSF MBP in relapsing multiple sclerosis patients treated with high dose intravenous methylprednisolone . ^^^ Before treatment , there was a significant correlation of Gd DTPA enhancement ( seen on 16 of 20 scans ) and CSF myelin basic protein ( MBP ) . ^^^ If enhancement with Gd DTPA represents inflammation and CSF MBP indicates myelin breakdown , the amount of inflamed tissue should correlate with the amount of myelin being damaged . ^^^ Clinical improvement occurred following 15 of 20 courses , and decrease of Gd DTPA enhancement in 12 of 16 scans ; the mean CSF MBP level was the only CSF variable to return to reference values . ^^^ There was a significant correlative triad of decrease in CSF MBP , Gd DTPA enhancement , and clinical disability . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
MBP reactive T cells were several fold enriched in the CSF of CVD patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Previous research has demonstrated a myelin basic protein ( MBP ) antibody cascade in cerebrospinal fluid ( CSF ) of multiple sclerosis ( MS ) patients . ^^^ Antibodies to MBP were isolated from purified CSF IgG of MS patients with acute relapses by two step antigen specific ( MBP Sepharose ) affinity chromatography . ^^^ Anti MBP in the context of whole CSF , in purified CSF IgG or as purified antibody , reacted identically with homologous and heterologous MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Within cerebrospinal fluid ( CSF ) , 37 % of IL 2 / IL 4 reactive T cell isolates from MS patients responded either to MBP or PLP 139 151 while only 5 % of similar isolates from OND patients responded to these myelin antigens . ^^^ The mean relative frequency of MBP reactive T cells within CSF from MS patients was significantly higher than that of OND patients ( 22 10 10 ( 5 ) cells versus 1 10 10 ( 5 ) cells ) and was similar to that of MBP reactive T cells within the central nervous system of rats with experimental autoimmune encephalomyelitis . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
GM CSF , IL 3 , and SF were each found to induce MAP kinase activity when assayed in vitro using myelin basic protein ( MBP ) as a substrate . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Studies on cerebrospinal fluid ( CSF ) concentrations of neuron specific enolase ( NSE ) , S 100 protein , and myelin basic protein ( MBP ) in patients with neurological lesions indicate a quantitative relation between the degree of cell damage in the central nervous system ( CNS ) and the concentration of these CNS specific proteins in CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
This result emphasizes the presence of B cells producing Abs against MBP in CSF of MS patients and shows the interest of studying mononuclear cells of CSF as a good marker of the pathogenesis . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Before MP treatment CSF MBP , IgG and IgM immunoglobulin levels ( CSF Ig , index and intrathecal synthesis ) were significantly elevated . ^^^ The mean CSF MBP levels were significantly higher in the relapsing remitting ( RR ) and chronic progressive MS patients with relapses ( CP + RR ) than in the CP group without a RR disease course , respectively 2 . 1 , 2 . 3 and 1 . 5 micrograms / l . ^^^ A weak positive correlation was found between CSF MBP level and EDSS in the RR MS group ( r = 0 . 34 ) . ^^^ CSF MBP was significantly correlated with IgM index ( r = 0 . 36 ) , IgM synthesis ( r = 0 . 26 ) , but not with the IgG levels . ^^^ The mean CSF MBP returned to reference values . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A calcium activated neutral proteinase ( calpain ) , which degrades MBP , was found to increase in activity in MS tissue and cerebrospinal fluid ( CSF ) , and its presence in myelin suggests that myelin may be autodigested in demyelinating disease . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
High dose intravenous methylprednisolone ( MP ) has a beneficial clinical effect ; reduces gadolinium enhancement , indicating improvement of BBB integrity ; and , in MS patients , decreases intrathecal immunoglobulin synthesis with reduction of cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) . ^^^ A correlative triad is noted between gadolinium enhancement , clinical improvement , and decrease of CSF MBP following MP treatment , indicating a relationship between restoration of BBB integrity , clinical improvement and decrease of myelin breakdown . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The level of MBP antibody in the cerebrospinal fluid ( CSF ) and serum of 20 rabbits with EAE was determined with ELISA respectively before and after sensitization with MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A rise in CSF IgG Index , MBP and DR+ cells in IFN treated patients suggested an activation of intrathecal immune response in treated patients . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
MBP reactive T cells were still more frequent among mononuclear cells isolated from the cerebrospinal fluid ( CSF ; 185 / 10 ( 5 ) CSF cells ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We evaluated the B cell response in cerebrospinal fluid ( CSF ) and blood by enumerating cells secreting antibodies to myelin associated glycoprotein ( MAG ) and , for reference , to myelin basic protein ( MBP ) , two myelin components which may constitute targets for autoimmune attack in multiple sclerosis ( MS ) . ^^^ In CSF from 2 out of 10 MS patients examined , anti MAG and anti MBP IgG antibody secreting cells were present concurrently . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Anti MBP IgG antibody secreting cells were detected in CSF from eight of 13 consecutive patients with Lyme neuroborreliosis irrespective of stage of disease . ^^^ Anti MBP IgG antibody secreting cells were also observed in the CSF from patients with a variety of other inflammatory diseases of the nervous system , and their role in the development of tissue damage remains unsettled . ^^^ Anti MBP IgG antibody secreting cells were not detected in the patients ' blood , reflecting accumulation of this autoantibody response to CSF . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) like material in 15 cerebrospinal fluid ( CSF ) samples from patients with multiple sclerosis ( MS ) was analyzed by isoelectric focusing ( IEF ) followed by immunoblot assay using rabbit antiserum against human MBP peptide 69 89 , which contains the dominant epitope for MBP like material . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
By immunoblotting , CSF IgG antibodies against myelin basic protein ( MBP ) were found in 3 of 12 patients with multiple sclerosis ( MS ) , but in none of the patients with PSS or in the 12 controls . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Although 56 . 7 % of immunologically normal and 68 . 8 % of immunocompromised patients had some CSF abnormality , no patient had an abnormal MBP level . ^^^ The lack of MBP elevation in the CSF of these patients suggests that the production of intrathecal IgG is not related to active demyelination . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Different epitopes residing within the decapeptide of residues 80 89 of human myelin basic protein ( MBP ) exist in the MBP like material detected in human CSF and urine . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Anti MBP IgG antibody secreting cells were present in MS patients ' cerebrospinal fluid ( CSF ) at a mean value of 1 per 833 cells , and they amounted to a mean value of about 2454 in the whole CSF compartment . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The results indicated that after the rabbits were sensitized with myelin basic protein ( MBP ) , the 5 HT levels in the CSF and serum of the rabbits with EAN increased . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Anti MBP in the context of whole CSF or in purified form reacts equally to MBP prepared from non MS or MS brain tissue . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We measured CSF immunoreactive myelin basic protein ( MBP ) , a marker of acute myelin damage , and sIL 2R levels in the CSF from 11 patients with active relapsing remitting ( RR ) MS , five with stable RR MS , eight with chronic progressive ( CP ) MS , five with other neurologic diseases , and three normal controls . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We have evaluated the antibody and the effector T cell responses to a single cerebrospinal fluid ( CSF ) infusion of myelin basic protein ( MBP ) in Lewis rats by measuring serum anti MBP antibodies and clinical signs of experimental autoimmune encephalomyelitis ( EAE ) , respectively . ^^^ The CSF route of MBP administration is more effective in inducing suppression of EAE than peripheral routes . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We evaluated cerebrospinal fluid ( CSF ) antibody levels against a lipid free , denatured form of myelin basic protein ( LF MBP ) in 11 patients with AIDS dementia complex ( ADC ) by using an enzyme linked immunosorbent assay ( ELISA ) . ^^^ At the same time , with the aim to detect early demyelinating events we investigated CSF antibody levels against a lipid bound , native like form of MBP ( LB MBP ) . ^^^ The detection of anti MBP antibodies in CSF may provide the opportunity to assess a diagnostic tool for discovering demyelinating lesions in ADC patients . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cells secreting antibodies against guinea pig myelin and synthetic myelin basic protein ( MBP ) peptides were evaluated in cerebrospinal fluid ( CSF ) and blood from patients with multiple sclerosis ( MS ) and a variety of other neurological diseases ( OND ) . ^^^ In CSF , cells secreting IgG antibodies to MBP 70 89 were more frequently ( p = 0 . 007 ) detected in patients with MS ( 1 / 380 IgG secreting cells on average ) than in patients with OND ( 1 / 2083 IgG secreting cells on average ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) level was elevated and serum anti myelin antibody was positive . ^^^ In addition to VEP and MRI studies , the CSF MBP and serum anti myelin antibody can be useful in the diagnosis and follow up the patients with optic neuritis . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Immunoglobulins isotypes ( IgG and IgM ) for myelin basic protein ( MBP ) , cerebrosides ( CER ) , gangliosides ( GANG ) and cardiolipin ( CARD ) were detected in the cerebrospinal fluid ( CSF ) from 33 patients with multiple sclerosis ( MS ) , 18 with Guillain Barr syndrome ( GBS ) and 30 with systemic lupus erythematosus ( SLE ) . ^^^ The CSF analysis of patients with GBS showed that 56 . 3 % revealed IgG MBP ( p less than 0 . 05 ) , 53 % for IgM MBP , 38 . 5 % for IgG CER and 23 % for IgM CER , while 50 % of patients had IgG CARD , as long as 31 % also had IgG GANG . ^^^ Except for 50 % of patients with SLE who presented positive CSF levels of IgG CARD , only 24 . 1 % had positive levels of IgG MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 115 patients with several neurological disorders were tested for the presence of myelin basic protein ( MBP ) , fragment P 1 43 88 . ^^^ The control group ( 50 patients with chronic headache ) presented normal CSF composition and presented no evidence of the presence of MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) was measured blind by double antibody competitive inhibition radioimmunoassay ( RIA ) in 20 children who had seizures and 17 children with hydrocephalus . ^^^ For individual patients CSF MBP is of little value as a prognostic indicator , or as a method of quantifying cerebral damage . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 221 patients with multiple sclerosis ( MS ) and 85 patients with other neurological disorders ( OND ) was examined using a competitive radioimmunoassay for myelin basic protein ( MBP ) immunoreactivity . ^^^ There was a significant correlation between the concentration of MBP in the CSF and relapse severity in patients seen within four weeks of the onset of symptoms ( p less than 0 . 01 ) . ^^^ In 72 patients with progressive disease the presence of MBP in the CSF reflected the confidence of clinical diagnosis . ^^^ The results of this study suggest that measurement of MBP in the CSF gives an objective method of monitoring disease activity in patient with MS . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) levels , CSF / serum albumin ratio ( CSF / S alb ) , and 4 CSF IgG measurements absolute CSF IgG level ( CSF IgG ) , CSF IgG / albumin ratio , the Tibbling Link IgG index , and the daily rate of intrathecal IgG synthesis were measured in patients with multiple sclerosis and control subjects . ^^^ In four clinical subgroups of patients , including 22 with polysymptomatic exacerbations , 22 with monosymptomatic exacerbations , 41 with chronic progressive disease , and 21 in remission , there was no correlation between CSF MBP and either CSF / S alb or the CSF IgG measurements . ^^^ CSF MBP levels , as determined in a cross sectional study of 325 patients with multiple sclerosis , are an excellent indicator of disease activity . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Levels of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) are useful in assessing the extent of demyelination which has occurred , or is occurring , in a variety of human problems associated with demyelination . ^^^ Thus , an accurate , specific , simple , and consistent test for detecting MBP in CSF is needed . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The results showed that closed head trauma caused moderate to severe elevations in CSF MBP , and elevated CSF MBP was detectable in several diseases which involve CNS myelin . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay was used to detect anti myelin basic protein ( MBP ) antibodies in the CSF and serum of multiple sclerosis ( MS ) patients and controls . ^^^ CSF and serum samples were assayed prior to acid hydrolysis in order to detect free anti MBP as well as after acid hydrolysis to measure the total ( free and bound ) amount of antibody . ^^^ MS patients with acute exacerbations or chronically progressive disease have significantly elevated levels of both free and total CSF anti MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Clinical exacerbations of multiple sclerosis ( MS ) are characterized by elevated levels of cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) . ^^^ The purposes of this study were to determine whether anti MBP antibodies are present in increased titer in CSF of MS patients with exacerbations , and whether they can be suppressed by the administration of immunosuppressive dosages of methylprednisolone ( MP ) . ^^^ A solid phase radio immunoassay ( RIA ) was used to detect free and total anti MBP antibodies before and after acid hydrolysis of CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The nervous system specific proteins glial fibrillary acidic protein ( GFAp ) , S 100 and myelin basic protein ( MBP ) were determined in 535 human cerebrospinal fluid ( CSF ) samples . ^^^ Increases in MBP in CSF of patients with acute demyelinating disease were confirmed . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Radioimmunoassay determined myelin basic protein ( MBP ) shed to CSF during active demyelination , has been found to be a useful but non specific test for MS . ^^^ Taking into account that the mean concentration of CSF CK BB should not be increased in patients during the acute phase of MS , we suggest that the CSF MBP / CK BB ratio could be a more specific index to demyelination than CSF MBP alone . ^^^ We also defined a laboratory demyelination pattern ( CSF MBP greater than mean control MBP + 2 S . ^^^ CSF levels of MBP and CSF levels of CK BB were determined by radioimmunoassay in 232 patients with several neurological disorders and 33 control subjects . ^^^ Patients diagnosed as having MS with clinical exacerbation had significantly higher values of CSF MBP / CSF BB ratio than control subjects . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
At various times animals were killed , numbers of leucocytes in their cerebrospinal fluid ( CSF ) quantified , and in vitro proliferative responses of blood lymphocytes to myelin basic protein ( MBP ) and its encephalitogenic nonapeptide ( NP ) determined . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The elevated CSF level of MBP is considered a marker of myelin damage and the increased concentration of CSF CK BB may be of combined neuronal and astrocytic origin . ^^^ CSF was collected from 57 patients with the diagnosis of CI ( n = 30 ) and ICT ( n = 27 ) and the concentration of MBP and CK BB were measured by RIA . ^^^ Our study shows increased CSF levels of MBP and CK BB in patients with CI and patients with ICT . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
To define in more detail the features of the immunoreactive myelin basic protein ( MBP ) present in cerebrospinal fluid ( CSF ) of humans following acute injury to central nervous system myelin , the epitopes of MBP recognized by three different antisera , each capable of detecting immunoreactive MBP in CSF , were examined . ^^^ Only in radioimmunoassays in which the MBP peptide 45 89 served as the radioligand could clearly elevated values of immunoreactive MBP be measured in CSF specimens from 5 patients with multiple sclerosis during or immediately after an exacerbation . ^^^ The two antisera that reacted well with MBP peptide 80 89 resulted in higher levels of immunoreactive MBP measured in CSF . ^^^ An epitope present in human MBP peptide 80 89 but sharing a conformation with both MBP and MBP peptide 45 89 is present in CSF following acute central nervous system myelin damage in multiple sclerosis . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The presence of myelin basic protein ( MBP ) like material in cerebrospinal fluid ( CSF ) usually reflects breakdown of central nervous system myelin . ^^^ Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies . ^^^ Immunoreactive MBP was present in CSF in 70 % ( 16 of 23 ) of patients with biopsy proved chronic demyelinating polyneuropathies , whereas in neuropathies producing primarily axonal damage it was present in only 22 % ( 5 of 23 ) . ^^^ In Guillain Barr syndrome , 45 % ( 9 of 20 ) of patients had immunoreactive MBP in the CSF . ^^^ We conclude that MBP like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P 1 protein . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Incubation of heated human myelin with CSF at 25 degrees C resulted in a marked reduction of myelin basic protein ( MBP ) with time . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) appears frequently in the cerebrospinal fluid ( CSF ) of mice with chronic demyelination following intracerebral infection with Theiler ' s murine encephalomyelitis virus ( TMEV ) ; antibody to MBP can frequently be found in the sera . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
IgG class antibodies reactive with myelin basic protein ( MBP ) were determined by enzyme linked immunosorbent assay ( ELISA ) in serum and cerebrospinal fluid ( CSF ) of 37 patients with multiple sclerosis and a control group of 32 patients with tension headache or psychoneurosis . ^^^ Ten ( 27 % ) of the multiple sclerosis CSF samples and 15 ( 41 % ) of the multiple sclerosis sera revealed anti MBP antibody levels exceeding 2 SD of the control group . ^^^ Seven patients ( 19 % ) showed exclusive or higher levels of anti MBP antibodies in CSF , suggesting synthesis within the central nervous system . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Activity to the latter could be removed from sera or CSF by absorption with MBP but not with histone or lysozyme . ^^^ In contrast to chronic relapsing EAE , CSF oligoclonal IgG from patients with multiple sclerosis showed no reactivity against human brain homogenate , whole myelin , delipidated myelin , and MBP in imprint electroimmunofixation . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We tested 104 patients for myelin basic protein ( MBP ) content in the CSF . ^^^ CSF MBP level was significantly higher in the MS group than in the other groups of patients , while no statistical difference was found between the MS patients with acute exacerbation and those in remission . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
At three time points post infection ( PI ) , immunoreactive myelin basic protein ( MBP ) was measured in cerebrospinal fluid ( CSF ) . ^^^ CSF from animals inoculated with Cornell A 75 17 strain often showed detectable immunoreactive MBP late in the disease course . ^^^ As anticipated from earlier morphological studies , CSF drawn around day 20 PI lacked MBP while subsequent samples were positive . ^^^ Release of MBP or MBP peptides into CSF of dogs with canine distemper may be a valuable laboratory test in studies of the natural history of this disease and in assessing the response to treatment . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Relapse was associated with detection of myelin basic protein ( MBP ) in the CSF ( p less than 0 . 01 ) , but not with decreased numbers of peripheral blood T lymphocytes . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Its precise measurement in the cerebrospinal fluid ( CSF ) has been uncommonly difficult , mainly due to immunoheterogeneity of MBP or MBP like material . ^^^ Many studies have demonstrated the release of MBP during relapses and elevated levels of MBP in the CSF can be detected if lumbar puncture is performed within 7 days of the onset of neurologic symptoms suggestive of MS . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The concentration of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) correlates with the development of experimental allergic encephalomyelitis following intradermal injection with encephalitogen in adjuvant ; MBP is absent in controls inoculated with adjuvants only . ^^^ The presence of MBP is a sensitive indicator of disease inasmuch as CNS inoculated mice with neurologic signs had an average of 0 . 29 ng / microliter of MBP in their CSF and controls , including normal or adjuvants only , had an average of 0 . 03 ng / microliter . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was serially measured in 177 CSF samples of 33 patients with leptomeningeal metastases and in 34 cancer controls . ^^^ CSF MBP levels were analysed in each stage . ^^^ Similar changes in levels of CSF MBP were also observed in longitudinal studies of patients responding to treatment or relapsing to the acute stage . ^^^ Eight patients developed treatment induced necrotizing leukoencephalopathy with typical CT scan findings ; elevated levels of CSF MBP were detected in 7 of them ( mean : 21 + / 3 ng / ml ) when measured within 2 weeks of diagnosis but not when measured 2 months earlier . ^^^ Our study suggests that in leptomeningeal metastases , CSF MBP levels are indicators of the disease activity , particularly if longitudinal determinations are used . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) was quantified from 28 patients with acute facial palsy . ^^^ The mean value of MBP in CSF in the study group was 3 . 4 + / 0 . 22 micrograms / l ( mean + / SEM ) , which was significantly higher than the found in 37 healthy subjects ( 2 . 4 + / 0 . 13 micrograms / l ) . ^^^ Using a 95 % confidence interval , 10 patients demonstrated significantly increased CSF concentrations of MBP ( greater than 3 . 95 micrograms / l ) . ^^^ No significant correlation was observed between elevated MBP in CSF and either pathologic auditory brainstem responses or the clinical degree of the palsy . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In contrast , five of nine T4+ clones from the CSF of a subject with postinfectious encephalomyelitis exhibited low but clear reactivity to human MBP , supporting the possible role of MBP as the target antigen in this disease . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Migration properties and occurrence of antibodies against myelin basic protein ( MBP ) in paired CSF and serum specimens from patients with multiple sclerosis ( MS ) were demonstrated after agarose isoelectric focusing , immunoblot transfer , and immunoperoxidase staining . ^^^ Oligoclonal IgG antibody bands directed against MBP were found in the CSF of 9 of 28 patients with MS ( 32 % ) , but not in the CSF of any of 34 patients with other neurologic diseases . ^^^ The CSF anti MBP antibodies migrated to the anodal region of the IgG area in a different fashion from oligoclonal IgG and anti measles IgG antibodies , which were detected in parallel . ^^^ Enzyme linked immunosorbent assay ( ELISA ) of serum and CSF for detection of IgG reactivity against MBP showed absorbance values above 2 standard deviations of controls in 44 % of the MS patients and in 21 % of those with other neurologic diseases . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The glial fibrillary acidic protein ( GFAP ) , myelin basic protein ( MBP ) , S 100 protein ( S 100 ) , gamma gamma enolase and neurofilament proteins were determined in the CSF of neurological patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The characteristics and heterogeneity of the myelin basic protein ( MBP ) like material appearing in cerebrospinal fluid ( CSF ) after acute central nervous system ( CNS ) myelin injury are unresolved . ^^^ In an effort to define further the MBP like material in CSF and to enhance its detection , a modified double antibody radioimmunoassay has been developed using a radioligand of human MBP synthetic peptide 69 89 . ^^^ Results with this assay provide additional confirmation of the presence of an epitope of MBP in the decapeptide of MBP 80 89 but in a conformation simulating that of intact MBP in CSF after CNS myelin injury . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
IL 2 receptor expression on cerebrospinal fluid lymphocytes ( CSF L ) either unstimulated or MBP stimulated was , however , significantly higher in both MS groups when compared to OND patients . ^^^ These results confirm the presence of activated lymphocytes in the CSF of MS patients during active stages of disease and suggest that this activation may be related to expansion of MBP specific cells . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Measurement of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) and visualization of the spinal cord using magnetic resonance imaging ( MRI ) gives a potentially accurate diagnosis of radiation myelopathy . ^^^ MBP levels in the CSF became strikingly elevated to 100 1000 times the normal value . ^^^ It appears that MBP levels in the CSF reflect not only radiation induced myelopathy but also transient demyelination , and that MRI may have the potential to indicate the region of damage . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
CSF levels of myelin basic protein ( MBP ) and intrathecally produced CSF IgG ( de novo IgG ) were measured in 11 chronic progressive multiple sclerosis patients with a deteriorating course of the disease for at least 6 months preceding observation and a reference group of 17 neurological patients suffering from disc herniation . ^^^ For multiple sclerosis patients the CSF MBP levels before treatment were significantly higher than for controls . ^^^ The CSF MBP levels after the treatment were nearly all within the control range . ^^^ A correlation between CSF MBP and CSF de novo IgG in multiple sclerosis patients could not be demonstrated . ^^^ If CSF MBP is an indicator of the ( activity of ) myelin breakdown in the brain , it can be concluded that an intensive immunosuppressive treatment in combination with prednisone has , at least , a short term , beneficial effect on the amount of demyelinisation and possibly on the disease activity . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The i . c . v . artificial cerebrospinal fluid ( CSF ) or ANF alone did not cause recognizable changes in mean blood pressure ( MBP ) , urinary volume ( UV ) , or sodium excretion ( UNaV ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Elevated myelin basic protein ( MBP ) levels in the cerebrospinal fluid ( CSF ) provide a marker for central nervous system demyelination . ^^^ The purpose of this study was to investigate the possible role of CSF MBP as a useful and early marker for HIV encephalopathy . ^^^ CSF MBP was elevated in 2 patients ( 5 . 0 and 5 . 3 ng / ml ) , both of whom had moderate to severe HIV encephalopathy . ^^^ In the remaining 38 patients , CSF MBP levels were marginally elevated ( n = 12 ) or normal ( n = 26 ) . ^^^ Our results suggest that CSF MBP is not a sensitive marker for the diagnosis and evaluation of HIV encephalopathy , but may be an indicator of prognosis for the course of the disease . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The levels of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) have been evaluated as a method of detecting central nervous system ( CNS ) demyelination . ^^^ MBP levels were measured in the CSF of 129 patients with neurological illnesses of whom 26 had a demyelinating illness . ^^^ Patients with CNS trauma also had high levels of MBP in their CSF . ^^^ The detection of a high level of MBP in CSF may be useful in the diagnosis of acute CNS demyelination but the finding is not specific for multiple sclerosis . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Both myelin basic protein ( MBP ) specific and histone specific protein methylase 1 activities were observed , the latter being generally higher in most CSF . ^^^ Identity of exogenously added MBP as the methylated substrate for CSF enzyme was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis . ^^^ Human CSF contained relatively high endogenous protein methylase 1 activity ( activity measured without added substrate protein ) : The endogenous substrate can be immunoprecipitated by antibody raised against calf brain MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
When enzyme linked immunosorbent assays ( ELISA ) for whole cord , myelin basic protein ( MBP ) or Mycobacterium tuberculosis were performed with CSF and plasma adjusted to the concentration of total IgG , the CSF / plasma ratios of ELISA results for specific antibodies were less then unity and ratios for whole cord and MBP were lower than those for M . tuberculosis . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate the effect of various therapeutic regimens on : 1 ) intrathecal IgG synthesis on the basis of IgG Index value , 2 ) oligoclonal IgG spectrum visualized by SDS PAGE of unconcentrated CSF , 3 ) CSF antibody specific activity against MBP estimated by solid phase RIA and expressed in cpm / micrograms IgG , and 4 ) immune complex ( CIC ) level in the CSF estimated by C1q binding solid phase RIA . ^^^ The moderate dose prednisone therapy and Mega dose Solu Medrol therapy on CSF IgG anti MBP antibody specific activity were less effective than the Mega dose prednisone medication . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Using a panel of antigens ( actin , myosin , tubulin , albumin , transferrin , peroxidase , thyroglobulin , DNA , prolactin , TNP and myelin basic protein ( MBP ] , we have tested the antibody activity of serum and cerebrospinal fluid ( CSF ) from healthy individuals , patients with multiple sclerosis ( MS ) and individuals with other neurological diseases . ^^^ Compared to the two other groups , the MS group had equivalent titres of anti MBP antibodies in the CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In a series of 35 severely head injured comatose patients , the cerebrospinal fluid ( CSF ) level of myelin basic protein ( MBP ) was analyzed by radioimmunoassay . ^^^ Measurement of CSF MBP appears to be a useful laboratory adjunct to clinical assessment , for judging the outcome of severely head injured patients . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay was used to detect antibodies to myelin basic protein ( MBP ) in the CSF of patients with multiple sclerosis ( MS ) and subacute sclerosing panencephalitis ( SSPE ) . ^^^ In view of the association of SSPE with measles virus and the presence of high titers of measles antibody in the CSF , antibodies to measles and to MBP may be directed against similar antigenic determinants . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
It has previously been demonstrated that both Myelin Basic Protein ( MBP ) and S 100 are released in the cerebrospinal fluid ( CSF ) of multiple sclerosis ( MS ) patients during acute phases of exacerbation of the disease . ^^^ In order to investigate the pathobiological significance of the release of these two proteins into the CSF , MBP and S 100 were assayed in 10 MS patients during the five weeks following onset of an acute exacerbation . ^^^ MBP was detectable in CSF during the first three weeks after exacerbation , while S 100 was detectable during the entire period of observation , at least in some of the patients . ^^^ MBP reached its highest CSF concentrations during the first two weeks while S 100 did so in the third week , decreasing thereafter . ^^^ This difference in time of presence of MBP and S 100 in the CSF is probably due to the different biological origin , MBP being a marker of myelin sheath injury , and S 100 , more probably , of astrocytic activity . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Similarly , change in visual evoked responses ( VER ) , and in number of oligoclonal bands ( OCB ) and the level of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) over the trial period did not differ significantly between the three groups . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Evaluation of antibody ( Ab ) responses at the cellular level , thereby bypassing draw backs inherent in determinations of circulating Ab levels , such as Ab binding to target , revealed that in one MS patient group , 57 % had , in CSF , cells secreting IgG Ab against myelin basic protein ( MBP ) and , in another MS group , 55 % had , in CSF , cells producing IgG Ab against myelin associated glycoprotein ( MAG ) ; both MBP and MAG are possible targets for immune attack in MS . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was demonstrated in the CSF of 15 out of 41 patients with assumed or ascertained neurosyphilis using a radio immunoassay . ^^^ In parenchymatous syphilis ( progressive paralysis , tabes dorsalis ) more than 50 % of patients had MBP positive CSF independent of immunological findings and previous treatment . ^^^ CSF of patients with meningovascular neurosyphilis was mostly negative , only in 2 cases with acute symptoms was MBP demonstrable . ^^^ In one of these patients MBP was no longer demonstrable in the CSF 6 months after treatment . ^^^ The frequent occurrence of MBP in CSF in parenchymatous neurosyphilis can be taken as evidence of persistence of demyelinising activity even in cases where immunological finding point to `` syphilis satis curata ' ' ( sufficiently treated syphilis ) . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Purified basic protein of myelin ( MBP ) was adsorbed onto polystyrene beads , followed by incubation in dilutions of serum or cerebrospinal fluid ( CSF ) . 125I labelled anti human IgG was used to quantify antibodies bound to the solid phase . ^^^ Serum and CSF specimens from 41 multiple sclerosis ( MS ) , 16 subacute sclerosing panencephalitis ( SSPE ) and 58 control patients were tested for MBP antibodies . ^^^ The SSPE patients had markedly elevated levels ( P 0 . 001 ) of antibodies to MBP in their CSF specimens . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In patients with multiple sclerosis low levels of antibody to MBP can be detected in cerebrospinal fluid ( CSF ) and acid eluted extracts from brain plaque material ; detection of low levels of antibody in human serum has not been possible due to non specific binding of human serum Ig in this RIA . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Nine dogs with canine distemper encephalitis ( CDE ) were examined with immunological techniques including demonstration of antibodies against canine distemper virus ( CDV ) in the serum and against myelin basic protein ( MBP ) in serum and in CSF . ^^^ Both dogs with chronic CDE had very high antibody titers against MBP in the CSF and demyelinating lesions contained immunoglobulin . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) and peripheral blood ( PB ) lymphocyte sensitization to rabbit myelin basic protein ( MBP ) in 44 multiple sclerosis ( MS ) patients , 21 patients with other neurological diseases ( OND ) and 14 persons with neurosis was studied with the antigen active rosette forming cells ( Ag ARFC ) assay . ^^^ The frequency of sensitization of CSF lymphocytes to MBP in groups of MS patients in the relapse stage and the chronic progressive stage was higher than in the group of MS patients in the stable stage and the OND patients . ^^^ In the patients who had suffered from MS for less than 4 years , sensitization to MBP was more common in CSF lymphocytes than in BP lymphocytes . ^^^ The results suggest that primary sensitization to MBP occurs in CSF , and is probably secondary to myelin damage . ^^^ However at present it is difficult to determine the extent to which sensitization of CSF and PB lymphocytes to MBP play a role in further demyelination processes . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 18 multiple sclerosis ( MS ) patients , 13 subacute sclerosing panencephalitis ( SSPE ) patients , 22 other neurological disease ( OND ) patients , and 7 neurotic patients as controls were tested in an 125I labeled anti human F ( ab ' ) 2 binding assay for the presence of antibodies to normal human brain cells from tissue culture , human fibroblasts , plasma membranes of MS and normal human brain , myelin basic protein ( MBP ) and bovine oligodendrocytes . ^^^ Antibodies to MBP and to oligodendrocytes were found in the CSF of MS , SSPE and OND patients . ^^^ Antibodies in the CSF against MBP and oligodendrocytes , on which some myelin determinants are expressed , seem to be a common feature of diseases in which demyelination is a component . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Serum and CSF levels of myelin basic protein ( MBP ) were measured in 50 patients with encephalitis of various origins and severity . ^^^ In nearly 50 % , the CSF samples were found to display immunoreactivity of MBP . ^^^ Positive tests of sera were infrequent , even from patients whose CSF was rich in MBP . ^^^ Longitudinal studies performed on 20 patients who were serially investigated during periods ranging from three weeks to 18 months demonstrated that after an attack , MBP liberation into the CSF persists for one to three weeks . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
To examine the specificity of these bands , a ) individual bands eluted from rabbit CSF and sera were tested by radioimmunoassay ( RIA ) for anti MBP activity and b ) rabbit sera were absorbed with the neuroantigens used for sensitization . ^^^ RIA of eluates from sequential agar gel slices of the entire IgG region of serum or CSF from MBP sensitized rabbits showed that anti MBP activity occurred throughout the IgG region and did not localize to specific band containing fractions . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay ( RIA ) was used to detect antibodies to myelin or myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with multiple sclerosis ( MS ) or other neurological diseases ( OND ) . ^^^ These results indicate that anti MBP antibodies are nt a feature of MS and binding of CSF IgG to myelin is not due to specific antibody , but is probably the result of non specific binding to Fc receptors . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Immunoreactive myelin basic protein ( MBP ) levels were measured in cerebrospinal fluid ( CSF ) samples taken from 57 patients with active hydrocephalus ( age range 3 weeks to 60 years ) . ^^^ Also associated with abnormal MBP levels was the ventricular size as measured by computerized tomography scanning ( chi 2 : p less than 0 . 05 ) : 36 % of the patients with small ventricles ( ventricle : brain ratio 0 to 0 . 4 : 1 ) had elevated MBP in the CSF , whereas 61 % of those with moderate ventricles ( 0 . 41 to 0 . 6 : 1 ratio ) and 100 % of those with large ventricles ( 0 . 61 to 0 . 85 : 1 ratio ) had abnormal values . ^^^ In three patients in whom CSF was obtained simultaneously by ventricular and lumbar punctures , the ventricular fluid had a consistently higher concentration of MBP , suggesting a cerebral origin . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
This study shows that the brain specific MBP in CSF is a useful marker of cerebral damage in acute cerebrovascular disease . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 40 multiple sclerosis ( MS ) patients was tested by solid phase radioimmunoassay ( RIA ) for ability to bind 2 common structural components of myelin and oligodendroglia , i . e . , to bind myelin basic protein ( MBP ) and myelin associated glycoprotein ( MAG ) . ^^^ Anti MAG and anti MBP CSF antibody activity was significantly higher , P less than or equal to 0 . 01 for both antibody specificity , in MS cases characterized by high IgG Index , greater than or equal to 0 . 70 = means + SD in the neurotic group , versus MS cases characterized by normal IgG Index ( less than or equal to 0 . 70 ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Distribution of myelin basic protein ( MBP ) in the central nervous system ( CNS ) following injection into the cerebrospinal fluid ( CSF ) was studied by different qualitative and quantitative immunelectron microscopic techniques . ^^^ After injection of exogenous MBP into CSF this protein was present in the subarachnoid space , on the surface of meningeal cells , on the surface of collagen fibers , in the basement membrane of the glia limitans , in vessel walls , and in the extracellular space of spinal roots . ^^^ Quantitative immunelectron microscopy ( an indirect technique with rabbit anti MBP serum as primary layer and gold labeled anti rabbit IgG as secondary layer ) revealed highly significant MBP binding on the luminal surface of endothelial cells after injection of this antigen into the CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In this study levels of neuron specific enolase ( NSE ) , S 100 protein ( S 100 ) and myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) of children and adults with distinct neurological disorders were examined . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
CSF mean MBP value of 15 CVD patients is markedly greater than that of OND group ( P < 0 . 05 ) . ^^^ No statistically significant differences are found in serum MBP values between OND group and normal control , and in serum and CSF Anti MBP values among six groups by using our method . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Expression of these cytokines was studied in mononuclear cells from peripheral blood and cerebrospinal fluid ( CSF ) from patients with ON and MS after in vitro exposure to MBP and PLP , and in absence of antigen . ^^^ There were elevated levels of cells that in response to MBP and PLP expressed IFN gamma , IL 4 and TGF beta mRNA in blood and further enriched in CSF in both ON and MS , compared to patients with other neurological diseases . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Raised ventricular CSF myelin basic protein ( MBP ) concentration has been evidenced in 17 shunted hydrocephalic patients . ^^^ In all cases the raised values of ventricular CSF concentration of MBP demonstrated a significant decrease after shunt operation . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) and proteolipid protein ( PLP ) were purified from non MS human brain and used in solid phase radioimmunoassays to detect their specific antibodies in cerebrospinal fluid ( CSF ) of optic neuritis and clinically definite multiple sclerosis ( MS ) patients . ^^^ The remaining 6 patients with undetectable anti MBP had increased levels of anti PLP in their CSF . ^^^ Three of the 4 remaining patients with undetectable anti MBP had increased anti PLP in their CSF . ^^^ Of 110 MS patients with chronic progressive disease , 107 had increased CSF anti MBP and 2 had elevated anti PLP . ^^^ Considering the total of 370 clinically definite MS patients with active and inactive disease , 77 % had increased CSF anti MBP and 1 % had increased CSF anti PLP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Optic neuritis and multiple sclerosis : anti MBP and anti MBP peptide antibody secreting cells are accumulated in CSF . ^^^ Using an immunospot assay to detect specific antibodies secreted by individual cells , we analyzed the B cell repertoire to MBP and its amino acid residues 1 20 , 63 88 , 110 128 , and 148 165 in blood and CSF from patients with ON and MS , and from controls . ^^^ The autonomy of the autoimmune B cell response in CSF was further supported by the pronounced asynchrony of the repertoire to the four MBP peptides in CSF compared with blood in individual patients . ^^^ The large numbers of MBP and MBP peptide reactive B cells in CSF in early MS , as manifested by ON , could play a major role in the immunopathogenesis and perpetuation of MS . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
This study reports the detection of autoantibodies to myelin basic protein ( MBP ) and neurofilament proteins ( NFP ) in serum and cerebrospinal fluid ( CSF ) of Japanese encephalitis patients . ^^^ Autoantibodies to either purified NFP ( 10 ) or MBP ( 8 ) or both ( 17 ) were detected in the CSF of 35 patients by ELISA in contrast with the control CSF samples . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In the cerebrospinal fluid ( CSF ) of MS patients , MBP reactive T cells generated with primary rIL 2 stimulation accounted for 7 % of the IL 2 responsive cells , greater than 10 fold higher than paired blood samples , and these T cells also selectively recognized MBP peptides 84 102 and 143 168 . ^^^ In striking contrast , MBP reactive T cells were not detected in CSF obtained from patients with other neurologic diseases . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with brain tumors and other neurological diseases was measured before , during and after various treatments such as surgery , chemotherapy and irradiation . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We questioned whether neuron specific enolase ( NSE ) and myelin basic protein ( MBP ) concentrations in cerebrospinal fluid ( CSF ) in the first 72 hours of life are correlated with the neurologic condition of asphyxiated full term infants in the neonatal period and at 1 year of age . ^^^ NSE and MBP concentrations in CSF at 12 and 72 hours of life were related to the degree of neonatal encephalopathy . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Concentrations of myelin basic protein ( MBP ) in ventricular and lumbar cerebrospinal fluid ( CSF ) of 20 pediatric hydrocephalic patients were reviewed . ^^^ Preliminary data gained from monitoring of MBP in the lumbar CSF in posthemorrhagic neonatal hydrocephalus could yield further criteria for indication of a shunt operation . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We measured the level of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with various kinds of tumors , including malignant tumors , using radioimmunoassay . ^^^ The level of MBP was high ( > 4 ng / ml ) in the patients with meningeal dissemination of malignant tumors , but in those who showed a good response to chemotherapy and / or radiation , it decreased or returned to the normal level , with improvement on the computed tomography and magnetic resonance imaging , cytological , general CSF , and neurological findings . ^^^ Of seven malignant gliomas without CSF dissemination , six showed an elevated level of MBP before selective intra arterial chemotherapy with a combination of etoposide and cisplatin administered via a microcatheter placed at A 1 , M 1 , P 1 P2 , and the basilar top . ^^^ All CSF specimens obtained during the period of the intra arterial chemotherapy showed an abnormally high ( > 4 ng / ml ) level of MBP that exceeded the prechemotherapy level . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In this study sera and cerebrospinal fluid ( CSF ) from 25 MS patients , 25 patients with other neurological diseases and 16 healthy controls were examined for antibodies against MBP by using radio immunoblot , western blot , radio immunoassay and enzyme linked immunosorbent assay . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
To verify the latter hypothesis , we searched for elevated anti myelin basic protein ( MBP ) IgG levels in the cerebrospinal fluid ( CSF ) and serum of 25 patients with HIV 1 infection , 12 with multiple sclerosis ( MS ) , and 9 with non inflammatory neurological diseases ( NIND ) . ^^^ CSF , but not serum , anti MBP IgG levels were more frequently elevated in HIV 1+ ( 16 / 25 , 64 % ) than in MS ( 3 / 12 , 25 % ) or NIND ( 0 / 9 ) patients . ^^^ The incidence of increased CSF anti MBP IgG levels was higher among HIV 1+ patients at stage 2 3 ( 4 / 4 , 100 % ) or at stage 4 B ( 7 / 9 , 78 % ) than among those at stage 4 C 4 D ( 5 / 12 , 42 % ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In the CSF , MBP levels were essentially constant until onset of paralysis . ^^^ Although increases in MBP in the CSF were associated with the onset of radiation induced myelopathy , its assay is unlikely to predict this complication of irradiation . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Expression of IL 10 was studied in blood MNC of MS and blood and cerebrospinal fluid ( CSF ) MNC of optic neuritis ( ON ) patients without culture and after culture in the presence of myelin basic protein ( MBP ) , the control antigen acetylcholine receptor ( AChR ) , and without antigen . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Degradation of purified myelin basic protein ( MBP ) was studied by SDS gel electrophoresis after addition of CSF samples obtained from HIV 1 infected patients . ^^^ In the ADC and PML patients , in addition to CSF proteolytic activity , an increase in CSF MBP levels and presence of white matter lesions were also observed by neuroimaging ( MRI ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We have examined the potential of IL 3 , IL 5 , and granulocyte macrophage ( GM ) CSF to enhance basophil activation by eosinophil granule major basic protein ( MBP ) . ^^^ Preincubation with GM CSF similarly enhanced MBP induced histamine release . ^^^ MBP also stimulated low levels of leukotriene C 4 ( LTC 4 ) release from basophils of 84 to 99 % purity , and experiments using enriched ( 18 63 % ) basophil preparations demonstrated that preincubation with IL 3 , IL 5 , and GM CSF also potentiated MBP stimulated leukotriene C 4 release up to threefold in parallel with histamine release . ^^^ These results indicate that IL 3 , IL 5 , and GM CSF may contribute to the pathogenesis of allergic and other disorders characterized by eosinophilia in part through potentiation of basophil mediator release stimulated by MBP . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The TCR 5 gene usage and CDR3s of these MBP reactive hprt T cell clones are homologous to TCRs from other T cells relevant to MS , including T cells causing experimental allergic encephalomyelitis ( EAE ) and T cells found in brain lesions and in the cerebrospinal fluid ( CSF ) of MS patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
T cell activities to MBP and the MBP amino acid sequences 63 88 , 110 128 and 148 165 were examined by short term cultures of mononuclear cells from cerebrospinal fluid ( CSF ) and blood in the presence of these antigens , and subsequent detection and counting of antigen specific T cells that responded by interferon gamma ( IFN gamma ) secretion . ^^^ Most patients with MS and ON had MBP and MBP peptide reactive T cells in CSF , amounting to mean values of between about 1 per 2000 and 1 per 7000 CSF cells and without immunodominance for any of the peptides . ^^^ The MBP peptide recognizing T cell repertoire was different in CSF than in blood in individual patients with ON and MS , thereby giving further evidence for an autonomy of the autoimmune T cell response in the CSF compartment . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Increased synthetic peptide specificity of tissue CSF bound anti MBP in multiple sclerosis . ^^^ Synthetic peptide specificity of free anti MBP purified from MS cerebrum was identical to previously reported specificity of free anti MBP from MS cerebrospinal fluid ( CSF ) , while tissue bound anti MBP , as well as bound anti MBP from CSF had a more restricted synthetic peptide specificity than free anti MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Our study was undertaken to determine if the levels of myelin basic protein ( MBP ) like material in cerebrospinal fluid ( CSF ) might indicate which patients with multiple sclerosis would show a short term ( 5 day ) or intermediate term ( 40 day ) improvement of at least a full grade Kurtzke disability score after initiating treatment with glucocorticoids . ^^^ CSF was obtained before initiation of treatment and analyzed for MBP like material by radioimmunoassay . ^^^ Individuals having a CSF MBP like material level of > or = 0 . 1 ng / ml overall showed a greater likelihood of continued improvement at day 40 ( p = 0 . 014 ) or further improvement between days 5 and 40 ( p = 0 . 003 ) . ^^^ Those in the first 15 days of worsening and with an elevated CSF MBP like level were more likely to respond by day 5 . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in CSF was increased in 2 of the 3 subjects studied . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) showed a mild elevation of both immunoglobulin G ( IgG ) and myelin basic protein ( MBP ) . ^^^ CSF IgG and MBP level showed a higher elevation than in the second episode . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The TCR 5 gene usage and CDR3s of these MBP reactive hprt T cell clones are homologous to TCRs from other T cells relevant to MS , including T cells causing experimental allergic encephalomyelitis ( EAE ) and T cells found in brain lesions and in the cerebrospinal fluid ( CSF ) of MS patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Anti MBP antibodies were found in the CSF of 16 % and in the sera of 20 % patients with MS . ^^^ MBP antibodies belonged to IgG 1 , IgG 2 and IgG 3 subclasses ( in the CSF ) and to IgG 1 and IgG 3 subclasses ( in the sera ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Previous research has demonstrated that free ( F ) and bound ( B ) anti myelin basic protein ( anti MBP ) can be detected in the cerebrospinal fluid ( CSF ) of patients with active multiple sclerosis ( MS ) . ^^^ Anti MBP which has previously been detected in the CSF of MS patients with active disease is also present as free antibody in the extracellular space of MS central nervous system tissue and in a smaller proportion as tissue bound antibody . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Cytokine production by T cells in the cerebrospinal fluid ( CSF ) and central nervous system ( CNS ) of SJL / J mice during myelin basic protein ( MBP ) induced experimental allergic encephalomyelitis ( EAE ) was examined . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
PLP , MOG and MAG reactive T cells are strongly enriched in the patients ' CSF , as previously also shown for MBP reactive T cells . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A double blind Phase 1 clinical research project was conducted in vivo in multiple sclerosis ( MS ) patients to determine the effect of myelin basic protein ( MBP ) synthetic peptides on free ( F ) and bound ( B ) titers of anti MBP in cerebrospinal fluid ( CSF ) . ^^^ Intravenous administration of MBP 75 95 resulted in significant decline of F and B CSF anti MBP levels over a period of one month . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In phase one clinical research , synthetic peptides ( p ) containing this epitope , namely pMBP 86 95 and / or pMBP 82 98 , were intrathecally administered to MS patients with monosymptomatic or polysymptomatic relapses to determine the dosage , frequency and duration of administration which will immediately neutralize F circulating CSF anti MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
NSE and MBP in the BD group were higher than those in the PVS group , thus CSF levels may be prognostic with regard to hypoxic brain injury . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The neuron specific enolase ( NSE ) , S 100 , myelin basic protein ( MBP ) and lactate levels were retrospectively analyzed in the CSF of 159 patients with various types of dementia . ^^^ The present study affirmed the strikingly high NSE and S 100 values in the CSF of patients with autopsydiagnosed Creutzfeld Jacob disease : NSE , S 100 and MBP levels in the CSF of patients with various other types of dementia , and controls , did not differ significantly . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We assessed human myelin basic protein ( MBP ) binding IgM levels in CSF . ^^^ CSF IgM anti MBP levels were assayed by measuring total IgM levels with solid phase ELISA in CSF samples from 66 patients with relapsing remitting MS , 11 subjects without neurological diseases , 20 patients with non inflammatory neurological diseases and 7 patients with lymphocytic meningitis , before and after immunoabsorption with human MBP . ^^^ Confirmation of IgM binding specificity was performed by immunoblotting of positive CSF samples onto MBP coated nitrocellulose sheets . ^^^ In this patient subgroup , IgM anti MBP levels correlated with the IgM index ( r = 0 . 71 ; P = 0 . 0001 ) , but not with CSF / serum albumin ( r = 0 . 08 ; P = 0 . 72 ) . ^^^ These findings demonstrate that in a subgroup of MS patients , elevated CSF levels of IgM anti MBP are associated with early favorable course and therefore suggest that IgM binding to MBP could be a possible prognostic marker in relapsing remitting MS to select early MS patients for future trials . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Serum and cerebrospinal fluid ( CSF ) from 20 HIV positive patients , including 14 with AIDS dementia complex ( CDC stage 4 ) and 6 asymptomatic individuals ( CDC stage 2 ) were analyzed by enzyme immunoassay for detection of antibodies to native myelin basic protein ( MBP ) and for the amino acid sequence 68 84 exposed after partial degradation of native MBP . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
METHODS : We assayed CSF mTF , TAT and myelin basic protein ( MBP ) in patients with SAH at intervals that included days 0 to 4 and days 5 to 9 after ictus . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Expanded CSF cells retained their capacity to respond to mitogen stimulation , but the proliferative response to myelin basic protein ( MBP ) was not enhanced . ^^^ Finally , freshly obtained CSF cells stimulated directly with MBP also expressed a limited number of 5 beta genes , although these were generally different from patterns observed following stimulation with TCGF / IL2 / IL4 . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) or a fragment thereof may enter cerebrospinal fluid ( CSF ) and other body fluids in an etiologically nonspecific fashion to provide information about the status of central nervous system ( CNS ) myelin damage . ^^^ The dominant epitope of CSF MBPLM is in the decapeptide of 80 89 from the intact MBP molecule of 170 residues . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Serial CSF samples were collected throughout treatment and concentrations of 5 methyltetrahydrofolate ( MTF ) , methionine ( MET ) , SAM , and myelin basic protein ( MBP ) were measured . ^^^ CSF MBP mirrored SAM concentration and there was a significant inverse relationship between the two . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The CSF concentrations of TCC , myelin basic protein ( MBP ) and neurological disability correlated significantly . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In demyelinating pathologies , MBP concentration in the cerebrospinal fluid ( CSF ) is considered to be a good marker of demyelination . ^^^ Our technique has the same sensitivity as RIA , needs only small volumes of CSF ( 50 microliters ) and the enzyme labelled MBP tracer is stable for at least 12 months . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Tolerance induction was monitored by quantification of MBP specific autoantibodies in cerebrospinal fluid ( CSF ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) registered 24 . 3 ng / ml . ^^^ Virological examinations showed 50 fold HSV 1 IgG in serum , and MBP in the CSF was 3 . 3 ng / ml . ^^^ The MBP measurement and virological tests of the CSF and serum prove extremely important in diagnosing an ascending myelitis of unknown cause . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The presence in CSF of MS patients of a cross reactive Id to different MBP peptides is indicative of an immune response to this encephalitogenic myelin protein in a segment of MS patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Therefore , the possible use of CSF MBP , S 100 , GFAP , N CAM , NGF , and CNTF in pathogenetic studies and in clinical follow up is critically reviewed . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Using a sensitive radioimmunoassay ( RIA ) , autoantibodies to myelin basic protein ( anti MBP ) can be detected in the CSF of 90 95 % of MS patients with active disease . ^^^ Between 1978 and 1998 , CSF was collected from 1 , 968 control non MS patients with psychiatric , inflammatory and noninflammatory neurological diseases as well as nonneurological systemic diseases , and anti MBP were measured by the same RIA used to detect anti MBP in MS CSF . ^^^ Anti MBP were undetectable in 98 % of CSF samples from non MS controls . ^^^ In the remaining 2 % of control samples , CSF IgGs capable of binding to MBP in vitro were unpredictably detected . ^^^ The high prevalence of free and / or bound anti MBP in the CSF of MS patients and the rare and unpredictable occurrence in the CSF of non MS patients suggest that autoimmunity to MBP may be operative in the demyelination of MS . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Activity of the disease process in MS is accompanied by myelin breakdown and appearance of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) . ^^^ In this paper MBP in CSF of relapsing remitting ( RR ) MS patients is reviewed . ^^^ MBP in CSF is a fragment containing an epitope corresponding to amino acid residues 45 89 of the native molecule . ^^^ From several relevant studies about CSF MBP in RR MS the following relations can be concluded : CSF MBP levels in active MS patients are frequently increased ( 45 100 % ) , remain increased until 5 to 6 weeks after onset symptoms and are higher in polysymptomatic exacerbations and correlate with number of gadolinium enhanced ( Gd ) lesions on MRI , severity of relapses , EDSS score and CSF intrathecal IgM synthesis . ^^^ After an intravenous methylprednisolone treatment the increased CSF MBP levels return to normal values and reduction in CSF MBP is related to reduction in EDSS score , number of Gd lesions and CSF intrathecal IgM synthesis . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
BACKGROUND : MBPLM in different immunochemical forms is detectable in human CSF and urine , presumably a result of myelin basic protein ( MBP ) catabolism . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
To investigate peptide effects on infiltrating cells , we collected cerebrospinal fluid ( CSF ) from ( PL / JxSJL ) F 1 mice with MBP induced EAE . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The concentration of MBP in CSF also correlated positively with the CSF leukocyte count , intrathecal IgG synthesis , and the CSF serum albumin concentration quotient . ^^^ The concentration of MBP in CSF correlated negatively with intrathecal IgA synthesis . ^^^ The results support the use of the concentration of MBP in CSF as a surrogate marker of disease activity during acute exacerbations of MS ; the data also link the presence of MBP in CSF to neuroimmunological parameters . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Hematological study indicated a compensated DIC and hepatic enzyme abnormality , while the CSF examinations showed an elevation of protein and positive myelin basic protein ( MBP ) elevation . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
There was a decrease in levels of some studied markers ( TNF in CSF , MBP level , IgG index , kappa chains in urine and kappa / creatinine ratio ) after the treatment , but the differences reached statistical significance in some groups only . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The results establish , in principle , that the same or very similar kappa light chain variable regions can be shared between CSF B lymphocytes from different individuals with MS as well as with certain antibodies against MBP . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
BACKGROUND : RIA of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) is commonly used as a biochemical marker of demyelination in patients with multiple sclerosis ( MS ) . ^^^ MBP was determined in CSF from 84 MS patients and 55 patients with other neurological diseases . ^^^ Most of the MS patients with acute exacerbations had markedly increased MBP in the CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The purpose of this Phase 1 open label clinical study was to monitor CSF anti MBP in patients with chronic progressive MS subsequent to 4 administration of synthetic peptide ( sp ) MBP 82 98 namely DEN ( 85 ) VVHFFKNIVTP ( 96 ) RT . ^^^ Fifty six patients who participated in this project were assigned to two groups : a ' control group ' of 15 patients who received 4 saline injections every 6 months for the first 2 years of the study and a ' peptide group ' of 41 patients who received 4 spMBP 82 98 from the beginning of the study and then infrequently subsequent to a rise of their CSF anti MBP . ^^^ Cohort C ( eight patients ) showed significant CSF anti MBP suppression after the initial injection but lost the ability to suppress the autoantibody titer following subsequent injections . ^^^ Cohort D ( eight patients ) failed to show significant CSF anti MBP suppression . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The initial value of myelin basic protein ( MBP ) in CSF was 0 . 9 ng / ml ( normal value : less than 4 ng / ml ) . ^^^ Subsequent measurement of MBP in CSF about two , six weeks , two , three , and six months after the onset showed a marked increase of 233 . 9 ng / ml followed by a gradual decrease of 25 . 4 ng / ml , 18 . 4 ng / ml , 7 . 4 ng / ml and 4 . 3 ng / ml , respectively . ^^^ Therefore , demyelination of the lesion in the cerebral white matter was suggested by the chronological change in FLAIR imaging and MBP in CSF . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
MBP , MOG , PLP , MAG ) , the presence of reactive T cells in blood and , further enriched , in the cerebrospinal fluid ( CSF ) , large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities , an increase of mononuclear cells ( MNC ) expressing and secreting both pro and anti inflammatory cytokines , including Th 1 cytokines interferon gamma ( IFN gamma ) and interleukin ( IL ) 6 , the Th 2 related IL 4 and IL 10 , and the Th 3 driven TGF beta , elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors , as well as many other aberrations . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
However , the clinical trials should be monitored by a large set of markers of MS activity , including the estimation of anti MBP antibodies , presence of MBP material in the CSF and concentration of sVCAM 1 , ICAM 1 , PECAM 1 in CSF and serum . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In the present study , membrane bound tissue factor ( mTF ) and myelin basic protein ( MBP ) concentrations in cerebrospinal fluid ( CSF ) were evaluated as a predictor of the time of occurrence of cerebral vasospasm . ^^^ The mTF and MBP concentrations were measured in the CSF from 28 patients with SAH due to ruptured aneurysm . ^^^ CSF mTF and MBP concentrations from days 5 to 9 correlated with the volume of cerebral infarction due to vasospasm and outcome three months after SAH . ^^^ In conclusion , CSF mTF is predictive of the occurrence and the recovery of cerebral vasospasm , while CSF MBP is only an indicator of severity of brain damage due to vasospasm . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In order to define an activity profile in patients with multiple sclerosis ( MS ) , T cell subpopulations and proliferative responses to myelin basic protein ( MBP ) associated with anti MBP antibodies , nitrotyrosine levels in serum and cerebrospinal fluid ( CSF ) , and serum CD40L ( sCD 154 ) were simultaneously assessed in 29 consecutive and untreated MS patients . ^^^ In addition , in vitro specific T cell proliferative responses against MBP ( SP / A , RR / A , SP / I : p < 0 . 001 versus controls ) in association with augmented sCD 154 serum levels ( SP / A , RR / A , versus controls p < 0 . 001 ) and a significant increase of both CSF and serum levels of anti MBP antibodies and nitrotyrosine levels ( p < 0 . 001 ) were also found . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
METHODS : During 41 CSF shunt operations ( both primarily placed shunts and shunt revisions ) CSF and blood samples were obtained and analysed for neuron specific enolase ( NSE ) , S 100b , glial fibrillary acidic protein ( GFAP ) and myelin basic protein ( MBP ) . ^^^ RESULTS : We observed significantly increased CSF levels of S 100b and GFAP in the hydrocephalic patients , whereas NSE and MBP were markedly increased only in patients with very severe symptoms . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
OBJECTIVES : To assess the concentrations of S 100 protein , myelin basic protein ( MBP ) , and lactate , and the ( CSF ) / serum albumin ratio ( Qalb ) during intracranial neurosurgical procedures . ^^^ METHODS : Samples of CSF from 91 patients with various CNS diseases were obtained by aspiration of cisternal CSF at the beginning of surgery ( before starting surgical manipulation of the brain ) and concentrations of S 100 protein , MBP , and lactate , and Qalb were determined . ^^^ Breaching of the arachnoid layer , documented at surgery for benign lesions , correlated with higher concentrations of MBP , lactate , CSF S 100 protein , and Qalb . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of MS patents is generally measured by radioimmunoassay . ^^^ We have recently established a sensitive enzyme linked immunosorbent assay ( ELISA ) and measured the MBP concentrations in CSF and serum of HAM / TSP patients . ^^^ METHODS : A sensitive two site ELISA capable of measuring MBP at a concentration as low as 30 pg / mL in serum and CSF samples was used . ^^^ RESULTS : Significantly higher CSF MBP concentrations were detected in 61 % of HAM / TSP patients than in patients with non neurological diseases . ^^^ CONCLUSIONS : Using our ELISA system , we detected MBP in CSF and serum not only in patients with central active demyelination as in MS , but also in patients with spinal cord demyelination as in HAM / TSP . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The presence of autoantibodies to the immunodominant antigen , myelin basic protein ( MBP ) , in the serum and cerebrospinal fluid ( CSF ) of patients with multiple sclerosis ( MS ) has been poorly characterized . ^^^ Autoantibodies capable of binding to MBP in the solution phase were not detected in the CSF or serum of patients with MS . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Protein S 100B , neuron specific enolase ( NSE ) , myelin basic protein ( MBP ) and glial fibrillary acidic protein ( GFAP ) in cerebrospinal fluid ( CSF ) and blood of neurological patients . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
A 2 B4O 4 injection facilitates emotional and spatial learning and memory , and pretreatment with anti acidic fibroblast growth factor ( aFGF ) antibody ICV eliminates these effects . aFGF is released from ependymal cells in the 3 cerebral ventricle in response to the glucose increase in CSF induced by 2 B4O 4 injection . 2 B4O also suppresses the clinical symptoms of experimental allergic encephalomyelitis ( EAE ) in Lewis rats [ induced by immunization with a myelin basic protein ( MBP ) ] , a model for human multiple sclerosis . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In addition , MRI neuro electrophysiologic examination and CSF myelin basic protein ( MBP ) concentration were monitored dynamically . ^^^ The MBP levels in CSF were ( 3 . 96 + / 1 . 66 ) ng / L , and ( 2 . 25 + / 1 . 66 ) ng / L before and 3 months after the treatment . ^^^ The level of MBP in CSF can reflect the severity of the lesion and prosthetic state of myelin sheath . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The expression of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) , hypothalamus and hippocampus of the limbic system , and temporoparietal cortex was investigated by enzyme linked immunosorbent assay and dot blot analysis . ^^^ The MBP level was markedly increased in the CSF ( p < 0 . 01 ) in the two trauma groups , in the hypothalamus of the low speed trauma group ( p < 0 . 05 ) , and in both the hypothalamus and the hippocampus of the high speed trauma group ( p < 0 . 01 ) . ^^^ The increase of MBP content in the CSF was positively correlated with the elevation of MBP concentration in the hypothalamus and hippocampus . ^^^ Meanwhile , the MBP level in the CSF may be a sensitive biological indicator for brain damage at the early stage of trauma related stress disorder . . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
The objectives of this study were ( 1 ) to determine how cerebrospinal fluid ( CSF ) neurofilament heavy chain ( NfH ( SM 134 ) and NfH ( SM 135 ) ) levels relate to clinical outcome in optic neuritis ( ON ) and multiple sclerosis ( MS ) relapse patients treated with high dose oral methylprednisolone ; and ( 2 ) to correlate neurofilament and myelin basic protein ( MBP ) concentrations , particularly as the latter was previously associated with clinical disability . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
We investigated whether serum and / or cerebrospinal fluid ( CSF ) concentrations of neuron specific enolase ( NSE ) , S100B , and myelin basic protein ( MBP ) are sensitive and specific for iTBI in high risk infants . ^^^ CONCLUSIONS : Serum and / or CSF concentrations of NSE and MBP may be useful as a screening test to identify infants who are at increased risk for iTBI and may benefit from additional evaluation with a head computed tomography scan . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Basing on their own data on the dynamics of NSP ( NSE , GFAR , and MBP ) concentrations and the proportions of these proteins in CSF and serum ( coefficient of elimination ) in rats after ischemic , hypoxic , and autoimmune cerebral lesions , the authors offer an algorithm of pathogenetic evaluation , including , on the one part , a conclusion on the presence or absence of a neurodegenerative process , and , on the other , a conclusion on a normal or lowered rate of NSP elimination ( metabolism ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Its administration in accordance with the principle of high dose tolerance results in long term suppression of anti myelin basic protein ( MBP ) autoantibody levels in the cerebrospinal fluid ( CSF ) of a large fraction of progressive MS patients . ^^^ Anti MBP autoantibody levels in the CSF of most MBP 8298 treated patients were suppressed , but antibody suppression was not predictive of clinical benefit . ^^^ Anti MBP autoantibodies that reappeared in the CSF of one patient at 36 months , whilst under treatment with MBP 8298 , were not reactive with the MBP 8298 peptide in vitro . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
METHOD : We investigated CSF and serum samples from 12 patients with first onset schizophrenia and from 17 control subjects by ELISA ( GFAP , MBP ) or immunoluminometric sandwich assays ( NSE , S100B ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
GM CSF coeluted with the cellular fractions containing granule markers ( MBP , ECP , eosinophil peroxidase , hexosaminidase , and arylsulphatase ) , but not those containing cytoplasm ( LDH+ ) or membrane ( CD9+ ) markers . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Assessment of the activities of the alpha and beta isoforms of conventional protein kinase C ( PKC ) , as determined by MonoQ column fractionated calcium and lipid activatible phosphotransferase activity towards myelin basic protein ( MBP ) revealed an additive effect of using LPS , IFN gamma and GM CSF , which was even greater than that demonstrated for phorbol myristate acetate ( PMA ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
In the present study , EAE DC were generated from bone marrow of Lewis rats , with EAE induced with MBP 68 86 + FCA , and expanded in vitro by culture with GM CSF and IL 4 . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Immunohistochemically , the tumor cells proved positive for S 100 , NSE , GFAP , MBP , chromogranin A and synaptophysin , and negative for CEA , keratin , HMB 45 , G CSF , and GM CSF . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
Freshly isolated UCB cells were cultured with IL 3 , IL 5 and GM CSF in the presence or absence of a gamma secretase inhibitor L 685 , 458 , and examined for the expression of major basic protein ( MBP ) . ^^^
Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P04141 and P13727	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was measured in the serum and CSF of patients with acute cerebrovascular disease ( CVD , 34 cases ) , demyelinating disorders ( DMD , 30 cases ) and other neurological diseases ( OND , 26 cases ) by using a double antibody radioimmunoassay ( RIA ) . ^^^ In CSF , MBP levels in patients with acute CVD and patients with DMD were significantly greater than those in OND patients ( P < 0 . 05 ) . ^^^ The results also show that there was a linear relationship between the CSF MBP levels and the serum MBP levels in patients with acute CVD ( r = 0 . 72 , P < 0 . 01 ) , but no such relationship in patients with DMD and OND . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was measured in cerebrospinal fluid ( CSF ) of patients with acquired immunodeficiency syndrome ( AIDS ) dementia complex ( ADC ) in order to investigate the degree of white matter destruction . ^^^ Results show that increased CSF levels of MBP were detected in all patients with severe ADC ( 10 / 10 ) and , less often , in subjects with mild ( 2 / 7 ) or moderate dementia ( 7 / 16 ) . ^^^ Our findings suggest that the measurement of CSF MBP concentration may represent a predictive marker of myelin injury and neurologic damage during the course of ADC . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A correlative triad of gadolinium DTPA MRI , EDSS , and CSF MBP in relapsing multiple sclerosis patients treated with high dose intravenous methylprednisolone . ^^^ Before treatment , there was a significant correlation of Gd DTPA enhancement ( seen on 16 of 20 scans ) and CSF myelin basic protein ( MBP ) . ^^^ If enhancement with Gd DTPA represents inflammation and CSF MBP indicates myelin breakdown , the amount of inflamed tissue should correlate with the amount of myelin being damaged . ^^^ Clinical improvement occurred following 15 of 20 courses , and decrease of Gd DTPA enhancement in 12 of 16 scans ; the mean CSF MBP level was the only CSF variable to return to reference values . ^^^ There was a significant correlative triad of decrease in CSF MBP , Gd DTPA enhancement , and clinical disability . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
MBP reactive T cells were several fold enriched in the CSF of CVD patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Previous research has demonstrated a myelin basic protein ( MBP ) antibody cascade in cerebrospinal fluid ( CSF ) of multiple sclerosis ( MS ) patients . ^^^ Antibodies to MBP were isolated from purified CSF IgG of MS patients with acute relapses by two step antigen specific ( MBP Sepharose ) affinity chromatography . ^^^ Anti MBP in the context of whole CSF , in purified CSF IgG or as purified antibody , reacted identically with homologous and heterologous MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Within cerebrospinal fluid ( CSF ) , 37 % of IL 2 / IL 4 reactive T cell isolates from MS patients responded either to MBP or PLP 139 151 while only 5 % of similar isolates from OND patients responded to these myelin antigens . ^^^ The mean relative frequency of MBP reactive T cells within CSF from MS patients was significantly higher than that of OND patients ( 22 10 10 ( 5 ) cells versus 1 10 10 ( 5 ) cells ) and was similar to that of MBP reactive T cells within the central nervous system of rats with experimental autoimmune encephalomyelitis . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
GM CSF , IL 3 , and SF were each found to induce MAP kinase activity when assayed in vitro using myelin basic protein ( MBP ) as a substrate . ^^^ GM CSF , IL 3 , and SF were each found to induce MAP kinase activity when assayed in vitro using myelin basic protein ( MBP ) as a substrate . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Studies on cerebrospinal fluid ( CSF ) concentrations of neuron specific enolase ( NSE ) , S 100 protein , and myelin basic protein ( MBP ) in patients with neurological lesions indicate a quantitative relation between the degree of cell damage in the central nervous system ( CNS ) and the concentration of these CNS specific proteins in CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
This result emphasizes the presence of B cells producing Abs against MBP in CSF of MS patients and shows the interest of studying mononuclear cells of CSF as a good marker of the pathogenesis . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Before MP treatment CSF MBP , IgG and IgM immunoglobulin levels ( CSF Ig , index and intrathecal synthesis ) were significantly elevated . ^^^ The mean CSF MBP levels were significantly higher in the relapsing remitting ( RR ) and chronic progressive MS patients with relapses ( CP + RR ) than in the CP group without a RR disease course , respectively 2 . 1 , 2 . 3 and 1 . 5 micrograms / l . ^^^ A weak positive correlation was found between CSF MBP level and EDSS in the RR MS group ( r = 0 . 34 ) . ^^^ CSF MBP was significantly correlated with IgM index ( r = 0 . 36 ) , IgM synthesis ( r = 0 . 26 ) , but not with the IgG levels . ^^^ The mean CSF MBP returned to reference values . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A calcium activated neutral proteinase ( calpain ) , which degrades MBP , was found to increase in activity in MS tissue and cerebrospinal fluid ( CSF ) , and its presence in myelin suggests that myelin may be autodigested in demyelinating disease . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
High dose intravenous methylprednisolone ( MP ) has a beneficial clinical effect ; reduces gadolinium enhancement , indicating improvement of BBB integrity ; and , in MS patients , decreases intrathecal immunoglobulin synthesis with reduction of cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) . ^^^ A correlative triad is noted between gadolinium enhancement , clinical improvement , and decrease of CSF MBP following MP treatment , indicating a relationship between restoration of BBB integrity , clinical improvement and decrease of myelin breakdown . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Although 56 . 7 % of immunologically normal and 68 . 8 % of immunocompromised patients had some CSF abnormality , no patient had an abnormal MBP level . ^^^ The lack of MBP elevation in the CSF of these patients suggests that the production of intrathecal IgG is not related to active demyelination . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Different epitopes residing within the decapeptide of residues 80 89 of human myelin basic protein ( MBP ) exist in the MBP like material detected in human CSF and urine . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Anti MBP IgG antibody secreting cells were present in MS patients ' cerebrospinal fluid ( CSF ) at a mean value of 1 per 833 cells , and they amounted to a mean value of about 2454 in the whole CSF compartment . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The level of MBP antibody in the cerebrospinal fluid ( CSF ) and serum of 20 rabbits with EAE was determined with ELISA respectively before and after sensitization with MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A rise in CSF IgG Index , MBP and DR+ cells in IFN treated patients suggested an activation of intrathecal immune response in treated patients . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
MBP reactive T cells were still more frequent among mononuclear cells isolated from the cerebrospinal fluid ( CSF ; 185 / 10 ( 5 ) CSF cells ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We evaluated the B cell response in cerebrospinal fluid ( CSF ) and blood by enumerating cells secreting antibodies to myelin associated glycoprotein ( MAG ) and , for reference , to myelin basic protein ( MBP ) , two myelin components which may constitute targets for autoimmune attack in multiple sclerosis ( MS ) . ^^^ In CSF from 2 out of 10 MS patients examined , anti MAG and anti MBP IgG antibody secreting cells were present concurrently . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Anti MBP IgG antibody secreting cells were detected in CSF from eight of 13 consecutive patients with Lyme neuroborreliosis irrespective of stage of disease . ^^^ Anti MBP IgG antibody secreting cells were also observed in the CSF from patients with a variety of other inflammatory diseases of the nervous system , and their role in the development of tissue damage remains unsettled . ^^^ Anti MBP IgG antibody secreting cells were not detected in the patients ' blood , reflecting accumulation of this autoantibody response to CSF . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) like material in 15 cerebrospinal fluid ( CSF ) samples from patients with multiple sclerosis ( MS ) was analyzed by isoelectric focusing ( IEF ) followed by immunoblot assay using rabbit antiserum against human MBP peptide 69 89 , which contains the dominant epitope for MBP like material . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
By immunoblotting , CSF IgG antibodies against myelin basic protein ( MBP ) were found in 3 of 12 patients with multiple sclerosis ( MS ) , but in none of the patients with PSS or in the 12 controls . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The results indicated that after the rabbits were sensitized with myelin basic protein ( MBP ) , the 5 HT levels in the CSF and serum of the rabbits with EAN increased . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Anti MBP in the context of whole CSF or in purified form reacts equally to MBP prepared from non MS or MS brain tissue . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We measured CSF immunoreactive myelin basic protein ( MBP ) , a marker of acute myelin damage , and sIL 2R levels in the CSF from 11 patients with active relapsing remitting ( RR ) MS , five with stable RR MS , eight with chronic progressive ( CP ) MS , five with other neurologic diseases , and three normal controls . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We have evaluated the antibody and the effector T cell responses to a single cerebrospinal fluid ( CSF ) infusion of myelin basic protein ( MBP ) in Lewis rats by measuring serum anti MBP antibodies and clinical signs of experimental autoimmune encephalomyelitis ( EAE ) , respectively . ^^^ The CSF route of MBP administration is more effective in inducing suppression of EAE than peripheral routes . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We evaluated cerebrospinal fluid ( CSF ) antibody levels against a lipid free , denatured form of myelin basic protein ( LF MBP ) in 11 patients with AIDS dementia complex ( ADC ) by using an enzyme linked immunosorbent assay ( ELISA ) . ^^^ At the same time , with the aim to detect early demyelinating events we investigated CSF antibody levels against a lipid bound , native like form of MBP ( LB MBP ) . ^^^ The detection of anti MBP antibodies in CSF may provide the opportunity to assess a diagnostic tool for discovering demyelinating lesions in ADC patients . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cells secreting antibodies against guinea pig myelin and synthetic myelin basic protein ( MBP ) peptides were evaluated in cerebrospinal fluid ( CSF ) and blood from patients with multiple sclerosis ( MS ) and a variety of other neurological diseases ( OND ) . ^^^ In CSF , cells secreting IgG antibodies to MBP 70 89 were more frequently ( p = 0 . 007 ) detected in patients with MS ( 1 / 380 IgG secreting cells on average ) than in patients with OND ( 1 / 2083 IgG secreting cells on average ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) level was elevated and serum anti myelin antibody was positive . ^^^ In addition to VEP and MRI studies , the CSF MBP and serum anti myelin antibody can be useful in the diagnosis and follow up the patients with optic neuritis . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Immunoglobulins isotypes ( IgG and IgM ) for myelin basic protein ( MBP ) , cerebrosides ( CER ) , gangliosides ( GANG ) and cardiolipin ( CARD ) were detected in the cerebrospinal fluid ( CSF ) from 33 patients with multiple sclerosis ( MS ) , 18 with Guillain Barr syndrome ( GBS ) and 30 with systemic lupus erythematosus ( SLE ) . ^^^ The CSF analysis of patients with GBS showed that 56 . 3 % revealed IgG MBP ( p less than 0 . 05 ) , 53 % for IgM MBP , 38 . 5 % for IgG CER and 23 % for IgM CER , while 50 % of patients had IgG CARD , as long as 31 % also had IgG GANG . ^^^ Except for 50 % of patients with SLE who presented positive CSF levels of IgG CARD , only 24 . 1 % had positive levels of IgG MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) levels , CSF / serum albumin ratio ( CSF / S alb ) , and 4 CSF IgG measurements absolute CSF IgG level ( CSF IgG ) , CSF IgG / albumin ratio , the Tibbling Link IgG index , and the daily rate of intrathecal IgG synthesis were measured in patients with multiple sclerosis and control subjects . ^^^ In four clinical subgroups of patients , including 22 with polysymptomatic exacerbations , 22 with monosymptomatic exacerbations , 41 with chronic progressive disease , and 21 in remission , there was no correlation between CSF MBP and either CSF / S alb or the CSF IgG measurements . ^^^ CSF MBP levels , as determined in a cross sectional study of 325 patients with multiple sclerosis , are an excellent indicator of disease activity . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Levels of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) are useful in assessing the extent of demyelination which has occurred , or is occurring , in a variety of human problems associated with demyelination . ^^^ Thus , an accurate , specific , simple , and consistent test for detecting MBP in CSF is needed . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The results showed that closed head trauma caused moderate to severe elevations in CSF MBP , and elevated CSF MBP was detectable in several diseases which involve CNS myelin . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 115 patients with several neurological disorders were tested for the presence of myelin basic protein ( MBP ) , fragment P 1 43 88 . ^^^ The control group ( 50 patients with chronic headache ) presented normal CSF composition and presented no evidence of the presence of MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) was measured blind by double antibody competitive inhibition radioimmunoassay ( RIA ) in 20 children who had seizures and 17 children with hydrocephalus . ^^^ For individual patients CSF MBP is of little value as a prognostic indicator , or as a method of quantifying cerebral damage . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 221 patients with multiple sclerosis ( MS ) and 85 patients with other neurological disorders ( OND ) was examined using a competitive radioimmunoassay for myelin basic protein ( MBP ) immunoreactivity . ^^^ There was a significant correlation between the concentration of MBP in the CSF and relapse severity in patients seen within four weeks of the onset of symptoms ( p less than 0 . 01 ) . ^^^ In 72 patients with progressive disease the presence of MBP in the CSF reflected the confidence of clinical diagnosis . ^^^ The results of this study suggest that measurement of MBP in the CSF gives an objective method of monitoring disease activity in patient with MS . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
At various times animals were killed , numbers of leucocytes in their cerebrospinal fluid ( CSF ) quantified , and in vitro proliferative responses of blood lymphocytes to myelin basic protein ( MBP ) and its encephalitogenic nonapeptide ( NP ) determined . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The elevated CSF level of MBP is considered a marker of myelin damage and the increased concentration of CSF CK BB may be of combined neuronal and astrocytic origin . ^^^ CSF was collected from 57 patients with the diagnosis of CI ( n = 30 ) and ICT ( n = 27 ) and the concentration of MBP and CK BB were measured by RIA . ^^^ Our study shows increased CSF levels of MBP and CK BB in patients with CI and patients with ICT . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay was used to detect anti myelin basic protein ( MBP ) antibodies in the CSF and serum of multiple sclerosis ( MS ) patients and controls . ^^^ CSF and serum samples were assayed prior to acid hydrolysis in order to detect free anti MBP as well as after acid hydrolysis to measure the total ( free and bound ) amount of antibody . ^^^ MS patients with acute exacerbations or chronically progressive disease have significantly elevated levels of both free and total CSF anti MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Clinical exacerbations of multiple sclerosis ( MS ) are characterized by elevated levels of cerebrospinal fluid ( CSF ) myelin basic protein ( MBP ) . ^^^ The purposes of this study were to determine whether anti MBP antibodies are present in increased titer in CSF of MS patients with exacerbations , and whether they can be suppressed by the administration of immunosuppressive dosages of methylprednisolone ( MP ) . ^^^ A solid phase radio immunoassay ( RIA ) was used to detect free and total anti MBP antibodies before and after acid hydrolysis of CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The nervous system specific proteins glial fibrillary acidic protein ( GFAp ) , S 100 and myelin basic protein ( MBP ) were determined in 535 human cerebrospinal fluid ( CSF ) samples . ^^^ Increases in MBP in CSF of patients with acute demyelinating disease were confirmed . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Radioimmunoassay determined myelin basic protein ( MBP ) shed to CSF during active demyelination , has been found to be a useful but non specific test for MS . ^^^ Taking into account that the mean concentration of CSF CK BB should not be increased in patients during the acute phase of MS , we suggest that the CSF MBP / CK BB ratio could be a more specific index to demyelination than CSF MBP alone . ^^^ We also defined a laboratory demyelination pattern ( CSF MBP greater than mean control MBP + 2 S . ^^^ CSF levels of MBP and CSF levels of CK BB were determined by radioimmunoassay in 232 patients with several neurological disorders and 33 control subjects . ^^^ Patients diagnosed as having MS with clinical exacerbation had significantly higher values of CSF MBP / CSF BB ratio than control subjects . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
IgG class antibodies reactive with myelin basic protein ( MBP ) were determined by enzyme linked immunosorbent assay ( ELISA ) in serum and cerebrospinal fluid ( CSF ) of 37 patients with multiple sclerosis and a control group of 32 patients with tension headache or psychoneurosis . ^^^ Ten ( 27 % ) of the multiple sclerosis CSF samples and 15 ( 41 % ) of the multiple sclerosis sera revealed anti MBP antibody levels exceeding 2 SD of the control group . ^^^ Seven patients ( 19 % ) showed exclusive or higher levels of anti MBP antibodies in CSF , suggesting synthesis within the central nervous system . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
To define in more detail the features of the immunoreactive myelin basic protein ( MBP ) present in cerebrospinal fluid ( CSF ) of humans following acute injury to central nervous system myelin , the epitopes of MBP recognized by three different antisera , each capable of detecting immunoreactive MBP in CSF , were examined . ^^^ Only in radioimmunoassays in which the MBP peptide 45 89 served as the radioligand could clearly elevated values of immunoreactive MBP be measured in CSF specimens from 5 patients with multiple sclerosis during or immediately after an exacerbation . ^^^ The two antisera that reacted well with MBP peptide 80 89 resulted in higher levels of immunoreactive MBP measured in CSF . ^^^ An epitope present in human MBP peptide 80 89 but sharing a conformation with both MBP and MBP peptide 45 89 is present in CSF following acute central nervous system myelin damage in multiple sclerosis . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The presence of myelin basic protein ( MBP ) like material in cerebrospinal fluid ( CSF ) usually reflects breakdown of central nervous system myelin . ^^^ Immunoreactive MBP levels were measured in 70 CSF specimens from 66 patients with a variety of peripheral neuropathies . ^^^ Immunoreactive MBP was present in CSF in 70 % ( 16 of 23 ) of patients with biopsy proved chronic demyelinating polyneuropathies , whereas in neuropathies producing primarily axonal damage it was present in only 22 % ( 5 of 23 ) . ^^^ In Guillain Barr syndrome , 45 % ( 9 of 20 ) of patients had immunoreactive MBP in the CSF . ^^^ We conclude that MBP like material is present in the CSF of most patients with longstanding demyelinating polyradiculoneuropathies and probably reflects detection of peripheral nervous system P 1 protein . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Incubation of heated human myelin with CSF at 25 degrees C resulted in a marked reduction of myelin basic protein ( MBP ) with time . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) appears frequently in the cerebrospinal fluid ( CSF ) of mice with chronic demyelination following intracerebral infection with Theiler ' s murine encephalomyelitis virus ( TMEV ) ; antibody to MBP can frequently be found in the sera . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Activity to the latter could be removed from sera or CSF by absorption with MBP but not with histone or lysozyme . ^^^ In contrast to chronic relapsing EAE , CSF oligoclonal IgG from patients with multiple sclerosis showed no reactivity against human brain homogenate , whole myelin , delipidated myelin , and MBP in imprint electroimmunofixation . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We tested 104 patients for myelin basic protein ( MBP ) content in the CSF . ^^^ CSF MBP level was significantly higher in the MS group than in the other groups of patients , while no statistical difference was found between the MS patients with acute exacerbation and those in remission . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
At three time points post infection ( PI ) , immunoreactive myelin basic protein ( MBP ) was measured in cerebrospinal fluid ( CSF ) . ^^^ CSF from animals inoculated with Cornell A 75 17 strain often showed detectable immunoreactive MBP late in the disease course . ^^^ As anticipated from earlier morphological studies , CSF drawn around day 20 PI lacked MBP while subsequent samples were positive . ^^^ Release of MBP or MBP peptides into CSF of dogs with canine distemper may be a valuable laboratory test in studies of the natural history of this disease and in assessing the response to treatment . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Relapse was associated with detection of myelin basic protein ( MBP ) in the CSF ( p less than 0 . 01 ) , but not with decreased numbers of peripheral blood T lymphocytes . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Its precise measurement in the cerebrospinal fluid ( CSF ) has been uncommonly difficult , mainly due to immunoheterogeneity of MBP or MBP like material . ^^^ Many studies have demonstrated the release of MBP during relapses and elevated levels of MBP in the CSF can be detected if lumbar puncture is performed within 7 days of the onset of neurologic symptoms suggestive of MS . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The concentration of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) correlates with the development of experimental allergic encephalomyelitis following intradermal injection with encephalitogen in adjuvant ; MBP is absent in controls inoculated with adjuvants only . ^^^ The presence of MBP is a sensitive indicator of disease inasmuch as CNS inoculated mice with neurologic signs had an average of 0 . 29 ng / microliter of MBP in their CSF and controls , including normal or adjuvants only , had an average of 0 . 03 ng / microliter . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was serially measured in 177 CSF samples of 33 patients with leptomeningeal metastases and in 34 cancer controls . ^^^ CSF MBP levels were analysed in each stage . ^^^ Similar changes in levels of CSF MBP were also observed in longitudinal studies of patients responding to treatment or relapsing to the acute stage . ^^^ Eight patients developed treatment induced necrotizing leukoencephalopathy with typical CT scan findings ; elevated levels of CSF MBP were detected in 7 of them ( mean : 21 + / 3 ng / ml ) when measured within 2 weeks of diagnosis but not when measured 2 months earlier . ^^^ Our study suggests that in leptomeningeal metastases , CSF MBP levels are indicators of the disease activity , particularly if longitudinal determinations are used . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) was quantified from 28 patients with acute facial palsy . ^^^ The mean value of MBP in CSF in the study group was 3 . 4 + / 0 . 22 micrograms / l ( mean + / SEM ) , which was significantly higher than the found in 37 healthy subjects ( 2 . 4 + / 0 . 13 micrograms / l ) . ^^^ Using a 95 % confidence interval , 10 patients demonstrated significantly increased CSF concentrations of MBP ( greater than 3 . 95 micrograms / l ) . ^^^ No significant correlation was observed between elevated MBP in CSF and either pathologic auditory brainstem responses or the clinical degree of the palsy . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In contrast , five of nine T4+ clones from the CSF of a subject with postinfectious encephalomyelitis exhibited low but clear reactivity to human MBP , supporting the possible role of MBP as the target antigen in this disease . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Migration properties and occurrence of antibodies against myelin basic protein ( MBP ) in paired CSF and serum specimens from patients with multiple sclerosis ( MS ) were demonstrated after agarose isoelectric focusing , immunoblot transfer , and immunoperoxidase staining . ^^^ Oligoclonal IgG antibody bands directed against MBP were found in the CSF of 9 of 28 patients with MS ( 32 % ) , but not in the CSF of any of 34 patients with other neurologic diseases . ^^^ The CSF anti MBP antibodies migrated to the anodal region of the IgG area in a different fashion from oligoclonal IgG and anti measles IgG antibodies , which were detected in parallel . ^^^ Enzyme linked immunosorbent assay ( ELISA ) of serum and CSF for detection of IgG reactivity against MBP showed absorbance values above 2 standard deviations of controls in 44 % of the MS patients and in 21 % of those with other neurologic diseases . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The glial fibrillary acidic protein ( GFAP ) , myelin basic protein ( MBP ) , S 100 protein ( S 100 ) , gamma gamma enolase and neurofilament proteins were determined in the CSF of neurological patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The characteristics and heterogeneity of the myelin basic protein ( MBP ) like material appearing in cerebrospinal fluid ( CSF ) after acute central nervous system ( CNS ) myelin injury are unresolved . ^^^ In an effort to define further the MBP like material in CSF and to enhance its detection , a modified double antibody radioimmunoassay has been developed using a radioligand of human MBP synthetic peptide 69 89 . ^^^ Results with this assay provide additional confirmation of the presence of an epitope of MBP in the decapeptide of MBP 80 89 but in a conformation simulating that of intact MBP in CSF after CNS myelin injury . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
IL 2 receptor expression on cerebrospinal fluid lymphocytes ( CSF L ) either unstimulated or MBP stimulated was , however , significantly higher in both MS groups when compared to OND patients . ^^^ These results confirm the presence of activated lymphocytes in the CSF of MS patients during active stages of disease and suggest that this activation may be related to expansion of MBP specific cells . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Measurement of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) and visualization of the spinal cord using magnetic resonance imaging ( MRI ) gives a potentially accurate diagnosis of radiation myelopathy . ^^^ MBP levels in the CSF became strikingly elevated to 100 1000 times the normal value . ^^^ It appears that MBP levels in the CSF reflect not only radiation induced myelopathy but also transient demyelination , and that MRI may have the potential to indicate the region of damage . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
CSF levels of myelin basic protein ( MBP ) and intrathecally produced CSF IgG ( de novo IgG ) were measured in 11 chronic progressive multiple sclerosis patients with a deteriorating course of the disease for at least 6 months preceding observation and a reference group of 17 neurological patients suffering from disc herniation . ^^^ For multiple sclerosis patients the CSF MBP levels before treatment were significantly higher than for controls . ^^^ The CSF MBP levels after the treatment were nearly all within the control range . ^^^ A correlation between CSF MBP and CSF de novo IgG in multiple sclerosis patients could not be demonstrated . ^^^ If CSF MBP is an indicator of the ( activity of ) myelin breakdown in the brain , it can be concluded that an intensive immunosuppressive treatment in combination with prednisone has , at least , a short term , beneficial effect on the amount of demyelinisation and possibly on the disease activity . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The i . c . v . artificial cerebrospinal fluid ( CSF ) or ANF alone did not cause recognizable changes in mean blood pressure ( MBP ) , urinary volume ( UV ) , or sodium excretion ( UNaV ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Elevated myelin basic protein ( MBP ) levels in the cerebrospinal fluid ( CSF ) provide a marker for central nervous system demyelination . ^^^ The purpose of this study was to investigate the possible role of CSF MBP as a useful and early marker for HIV encephalopathy . ^^^ CSF MBP was elevated in 2 patients ( 5 . 0 and 5 . 3 ng / ml ) , both of whom had moderate to severe HIV encephalopathy . ^^^ In the remaining 38 patients , CSF MBP levels were marginally elevated ( n = 12 ) or normal ( n = 26 ) . ^^^ Our results suggest that CSF MBP is not a sensitive marker for the diagnosis and evaluation of HIV encephalopathy , but may be an indicator of prognosis for the course of the disease . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The levels of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) have been evaluated as a method of detecting central nervous system ( CNS ) demyelination . ^^^ MBP levels were measured in the CSF of 129 patients with neurological illnesses of whom 26 had a demyelinating illness . ^^^ Patients with CNS trauma also had high levels of MBP in their CSF . ^^^ The detection of a high level of MBP in CSF may be useful in the diagnosis of acute CNS demyelination but the finding is not specific for multiple sclerosis . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Both myelin basic protein ( MBP ) specific and histone specific protein methylase 1 activities were observed , the latter being generally higher in most CSF . ^^^ Identity of exogenously added MBP as the methylated substrate for CSF enzyme was confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis . ^^^ Human CSF contained relatively high endogenous protein methylase 1 activity ( activity measured without added substrate protein ) : The endogenous substrate can be immunoprecipitated by antibody raised against calf brain MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
When enzyme linked immunosorbent assays ( ELISA ) for whole cord , myelin basic protein ( MBP ) or Mycobacterium tuberculosis were performed with CSF and plasma adjusted to the concentration of total IgG , the CSF / plasma ratios of ELISA results for specific antibodies were less then unity and ratios for whole cord and MBP were lower than those for M . tuberculosis . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate the effect of various therapeutic regimens on : 1 ) intrathecal IgG synthesis on the basis of IgG Index value , 2 ) oligoclonal IgG spectrum visualized by SDS PAGE of unconcentrated CSF , 3 ) CSF antibody specific activity against MBP estimated by solid phase RIA and expressed in cpm / micrograms IgG , and 4 ) immune complex ( CIC ) level in the CSF estimated by C1q binding solid phase RIA . ^^^ The moderate dose prednisone therapy and Mega dose Solu Medrol therapy on CSF IgG anti MBP antibody specific activity were less effective than the Mega dose prednisone medication . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
It has previously been demonstrated that both Myelin Basic Protein ( MBP ) and S 100 are released in the cerebrospinal fluid ( CSF ) of multiple sclerosis ( MS ) patients during acute phases of exacerbation of the disease . ^^^ In order to investigate the pathobiological significance of the release of these two proteins into the CSF , MBP and S 100 were assayed in 10 MS patients during the five weeks following onset of an acute exacerbation . ^^^ MBP was detectable in CSF during the first three weeks after exacerbation , while S 100 was detectable during the entire period of observation , at least in some of the patients . ^^^ MBP reached its highest CSF concentrations during the first two weeks while S 100 did so in the third week , decreasing thereafter . ^^^ This difference in time of presence of MBP and S 100 in the CSF is probably due to the different biological origin , MBP being a marker of myelin sheath injury , and S 100 , more probably , of astrocytic activity . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Similarly , change in visual evoked responses ( VER ) , and in number of oligoclonal bands ( OCB ) and the level of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) over the trial period did not differ significantly between the three groups . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Evaluation of antibody ( Ab ) responses at the cellular level , thereby bypassing draw backs inherent in determinations of circulating Ab levels , such as Ab binding to target , revealed that in one MS patient group , 57 % had , in CSF , cells secreting IgG Ab against myelin basic protein ( MBP ) and , in another MS group , 55 % had , in CSF , cells producing IgG Ab against myelin associated glycoprotein ( MAG ) ; both MBP and MAG are possible targets for immune attack in MS . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Using a panel of antigens ( actin , myosin , tubulin , albumin , transferrin , peroxidase , thyroglobulin , DNA , prolactin , TNP and myelin basic protein ( MBP ] , we have tested the antibody activity of serum and cerebrospinal fluid ( CSF ) from healthy individuals , patients with multiple sclerosis ( MS ) and individuals with other neurological diseases . ^^^ Compared to the two other groups , the MS group had equivalent titres of anti MBP antibodies in the CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In a series of 35 severely head injured comatose patients , the cerebrospinal fluid ( CSF ) level of myelin basic protein ( MBP ) was analyzed by radioimmunoassay . ^^^ Measurement of CSF MBP appears to be a useful laboratory adjunct to clinical assessment , for judging the outcome of severely head injured patients . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay was used to detect antibodies to myelin basic protein ( MBP ) in the CSF of patients with multiple sclerosis ( MS ) and subacute sclerosing panencephalitis ( SSPE ) . ^^^ In view of the association of SSPE with measles virus and the presence of high titers of measles antibody in the CSF , antibodies to measles and to MBP may be directed against similar antigenic determinants . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) was demonstrated in the CSF of 15 out of 41 patients with assumed or ascertained neurosyphilis using a radio immunoassay . ^^^ In parenchymatous syphilis ( progressive paralysis , tabes dorsalis ) more than 50 % of patients had MBP positive CSF independent of immunological findings and previous treatment . ^^^ CSF of patients with meningovascular neurosyphilis was mostly negative , only in 2 cases with acute symptoms was MBP demonstrable . ^^^ In one of these patients MBP was no longer demonstrable in the CSF 6 months after treatment . ^^^ The frequent occurrence of MBP in CSF in parenchymatous neurosyphilis can be taken as evidence of persistence of demyelinising activity even in cases where immunological finding point to `` syphilis satis curata ' ' ( sufficiently treated syphilis ) . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Purified basic protein of myelin ( MBP ) was adsorbed onto polystyrene beads , followed by incubation in dilutions of serum or cerebrospinal fluid ( CSF ) . 125I labelled anti human IgG was used to quantify antibodies bound to the solid phase . ^^^ Serum and CSF specimens from 41 multiple sclerosis ( MS ) , 16 subacute sclerosing panencephalitis ( SSPE ) and 58 control patients were tested for MBP antibodies . ^^^ The SSPE patients had markedly elevated levels ( P 0 . 001 ) of antibodies to MBP in their CSF specimens . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In patients with multiple sclerosis low levels of antibody to MBP can be detected in cerebrospinal fluid ( CSF ) and acid eluted extracts from brain plaque material ; detection of low levels of antibody in human serum has not been possible due to non specific binding of human serum Ig in this RIA . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Nine dogs with canine distemper encephalitis ( CDE ) were examined with immunological techniques including demonstration of antibodies against canine distemper virus ( CDV ) in the serum and against myelin basic protein ( MBP ) in serum and in CSF . ^^^ Both dogs with chronic CDE had very high antibody titers against MBP in the CSF and demyelinating lesions contained immunoglobulin . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) and peripheral blood ( PB ) lymphocyte sensitization to rabbit myelin basic protein ( MBP ) in 44 multiple sclerosis ( MS ) patients , 21 patients with other neurological diseases ( OND ) and 14 persons with neurosis was studied with the antigen active rosette forming cells ( Ag ARFC ) assay . ^^^ The frequency of sensitization of CSF lymphocytes to MBP in groups of MS patients in the relapse stage and the chronic progressive stage was higher than in the group of MS patients in the stable stage and the OND patients . ^^^ In the patients who had suffered from MS for less than 4 years , sensitization to MBP was more common in CSF lymphocytes than in BP lymphocytes . ^^^ The results suggest that primary sensitization to MBP occurs in CSF , and is probably secondary to myelin damage . ^^^ However at present it is difficult to determine the extent to which sensitization of CSF and PB lymphocytes to MBP play a role in further demyelination processes . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Serum and CSF levels of myelin basic protein ( MBP ) were measured in 50 patients with encephalitis of various origins and severity . ^^^ In nearly 50 % , the CSF samples were found to display immunoreactivity of MBP . ^^^ Positive tests of sera were infrequent , even from patients whose CSF was rich in MBP . ^^^ Longitudinal studies performed on 20 patients who were serially investigated during periods ranging from three weeks to 18 months demonstrated that after an attack , MBP liberation into the CSF persists for one to three weeks . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
To examine the specificity of these bands , a ) individual bands eluted from rabbit CSF and sera were tested by radioimmunoassay ( RIA ) for anti MBP activity and b ) rabbit sera were absorbed with the neuroantigens used for sensitization . ^^^ RIA of eluates from sequential agar gel slices of the entire IgG region of serum or CSF from MBP sensitized rabbits showed that anti MBP activity occurred throughout the IgG region and did not localize to specific band containing fractions . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A solid phase radioimmunoassay ( RIA ) was used to detect antibodies to myelin or myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with multiple sclerosis ( MS ) or other neurological diseases ( OND ) . ^^^ These results indicate that anti MBP antibodies are nt a feature of MS and binding of CSF IgG to myelin is not due to specific antibody , but is probably the result of non specific binding to Fc receptors . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Immunoreactive myelin basic protein ( MBP ) levels were measured in cerebrospinal fluid ( CSF ) samples taken from 57 patients with active hydrocephalus ( age range 3 weeks to 60 years ) . ^^^ Also associated with abnormal MBP levels was the ventricular size as measured by computerized tomography scanning ( chi 2 : p less than 0 . 05 ) : 36 % of the patients with small ventricles ( ventricle : brain ratio 0 to 0 . 4 : 1 ) had elevated MBP in the CSF , whereas 61 % of those with moderate ventricles ( 0 . 41 to 0 . 6 : 1 ratio ) and 100 % of those with large ventricles ( 0 . 61 to 0 . 85 : 1 ratio ) had abnormal values . ^^^ In three patients in whom CSF was obtained simultaneously by ventricular and lumbar punctures , the ventricular fluid had a consistently higher concentration of MBP , suggesting a cerebral origin . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 18 multiple sclerosis ( MS ) patients , 13 subacute sclerosing panencephalitis ( SSPE ) patients , 22 other neurological disease ( OND ) patients , and 7 neurotic patients as controls were tested in an 125I labeled anti human F ( ab ' ) 2 binding assay for the presence of antibodies to normal human brain cells from tissue culture , human fibroblasts , plasma membranes of MS and normal human brain , myelin basic protein ( MBP ) and bovine oligodendrocytes . ^^^ Antibodies to MBP and to oligodendrocytes were found in the CSF of MS , SSPE and OND patients . ^^^ Antibodies in the CSF against MBP and oligodendrocytes , on which some myelin determinants are expressed , seem to be a common feature of diseases in which demyelination is a component . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
This study shows that the brain specific MBP in CSF is a useful marker of cerebral damage in acute cerebrovascular disease . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) from 40 multiple sclerosis ( MS ) patients was tested by solid phase radioimmunoassay ( RIA ) for ability to bind 2 common structural components of myelin and oligodendroglia , i . e . , to bind myelin basic protein ( MBP ) and myelin associated glycoprotein ( MAG ) . ^^^ Anti MAG and anti MBP CSF antibody activity was significantly higher , P less than or equal to 0 . 01 for both antibody specificity , in MS cases characterized by high IgG Index , greater than or equal to 0 . 70 = means + SD in the neurotic group , versus MS cases characterized by normal IgG Index ( less than or equal to 0 . 70 ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Distribution of myelin basic protein ( MBP ) in the central nervous system ( CNS ) following injection into the cerebrospinal fluid ( CSF ) was studied by different qualitative and quantitative immunelectron microscopic techniques . ^^^ After injection of exogenous MBP into CSF this protein was present in the subarachnoid space , on the surface of meningeal cells , on the surface of collagen fibers , in the basement membrane of the glia limitans , in vessel walls , and in the extracellular space of spinal roots . ^^^ Quantitative immunelectron microscopy ( an indirect technique with rabbit anti MBP serum as primary layer and gold labeled anti rabbit IgG as secondary layer ) revealed highly significant MBP binding on the luminal surface of endothelial cells after injection of this antigen into the CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In this study levels of neuron specific enolase ( NSE ) , S 100 protein ( S 100 ) and myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) of children and adults with distinct neurological disorders were examined . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
CSF mean MBP value of 15 CVD patients is markedly greater than that of OND group ( P < 0 . 05 ) . ^^^ No statistically significant differences are found in serum MBP values between OND group and normal control , and in serum and CSF Anti MBP values among six groups by using our method . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Expression of these cytokines was studied in mononuclear cells from peripheral blood and cerebrospinal fluid ( CSF ) from patients with ON and MS after in vitro exposure to MBP and PLP , and in absence of antigen . ^^^ There were elevated levels of cells that in response to MBP and PLP expressed IFN gamma , IL 4 and TGF beta mRNA in blood and further enriched in CSF in both ON and MS , compared to patients with other neurological diseases . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Raised ventricular CSF myelin basic protein ( MBP ) concentration has been evidenced in 17 shunted hydrocephalic patients . ^^^ In all cases the raised values of ventricular CSF concentration of MBP demonstrated a significant decrease after shunt operation . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In the cerebrospinal fluid ( CSF ) of MS patients , MBP reactive T cells generated with primary rIL 2 stimulation accounted for 7 % of the IL 2 responsive cells , greater than 10 fold higher than paired blood samples , and these T cells also selectively recognized MBP peptides 84 102 and 143 168 . ^^^ In striking contrast , MBP reactive T cells were not detected in CSF obtained from patients with other neurologic diseases . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with brain tumors and other neurological diseases was measured before , during and after various treatments such as surgery , chemotherapy and irradiation . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We questioned whether neuron specific enolase ( NSE ) and myelin basic protein ( MBP ) concentrations in cerebrospinal fluid ( CSF ) in the first 72 hours of life are correlated with the neurologic condition of asphyxiated full term infants in the neonatal period and at 1 year of age . ^^^ NSE and MBP concentrations in CSF at 12 and 72 hours of life were related to the degree of neonatal encephalopathy . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) and proteolipid protein ( PLP ) were purified from non MS human brain and used in solid phase radioimmunoassays to detect their specific antibodies in cerebrospinal fluid ( CSF ) of optic neuritis and clinically definite multiple sclerosis ( MS ) patients . ^^^ The remaining 6 patients with undetectable anti MBP had increased levels of anti PLP in their CSF . ^^^ Three of the 4 remaining patients with undetectable anti MBP had increased anti PLP in their CSF . ^^^ Of 110 MS patients with chronic progressive disease , 107 had increased CSF anti MBP and 2 had elevated anti PLP . ^^^ Considering the total of 370 clinically definite MS patients with active and inactive disease , 77 % had increased CSF anti MBP and 1 % had increased CSF anti PLP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Optic neuritis and multiple sclerosis : anti MBP and anti MBP peptide antibody secreting cells are accumulated in CSF . ^^^ Using an immunospot assay to detect specific antibodies secreted by individual cells , we analyzed the B cell repertoire to MBP and its amino acid residues 1 20 , 63 88 , 110 128 , and 148 165 in blood and CSF from patients with ON and MS , and from controls . ^^^ The autonomy of the autoimmune B cell response in CSF was further supported by the pronounced asynchrony of the repertoire to the four MBP peptides in CSF compared with blood in individual patients . ^^^ The large numbers of MBP and MBP peptide reactive B cells in CSF in early MS , as manifested by ON , could play a major role in the immunopathogenesis and perpetuation of MS . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
This study reports the detection of autoantibodies to myelin basic protein ( MBP ) and neurofilament proteins ( NFP ) in serum and cerebrospinal fluid ( CSF ) of Japanese encephalitis patients . ^^^ Autoantibodies to either purified NFP ( 10 ) or MBP ( 8 ) or both ( 17 ) were detected in the CSF of 35 patients by ELISA in contrast with the control CSF samples . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Concentrations of myelin basic protein ( MBP ) in ventricular and lumbar cerebrospinal fluid ( CSF ) of 20 pediatric hydrocephalic patients were reviewed . ^^^ Preliminary data gained from monitoring of MBP in the lumbar CSF in posthemorrhagic neonatal hydrocephalus could yield further criteria for indication of a shunt operation . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We measured the level of myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of patients with various kinds of tumors , including malignant tumors , using radioimmunoassay . ^^^ The level of MBP was high ( > 4 ng / ml ) in the patients with meningeal dissemination of malignant tumors , but in those who showed a good response to chemotherapy and / or radiation , it decreased or returned to the normal level , with improvement on the computed tomography and magnetic resonance imaging , cytological , general CSF , and neurological findings . ^^^ Of seven malignant gliomas without CSF dissemination , six showed an elevated level of MBP before selective intra arterial chemotherapy with a combination of etoposide and cisplatin administered via a microcatheter placed at A 1 , M 1 , P 1 P2 , and the basilar top . ^^^ All CSF specimens obtained during the period of the intra arterial chemotherapy showed an abnormally high ( > 4 ng / ml ) level of MBP that exceeded the prechemotherapy level . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In this study sera and cerebrospinal fluid ( CSF ) from 25 MS patients , 25 patients with other neurological diseases and 16 healthy controls were examined for antibodies against MBP by using radio immunoblot , western blot , radio immunoassay and enzyme linked immunosorbent assay . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
To verify the latter hypothesis , we searched for elevated anti myelin basic protein ( MBP ) IgG levels in the cerebrospinal fluid ( CSF ) and serum of 25 patients with HIV 1 infection , 12 with multiple sclerosis ( MS ) , and 9 with non inflammatory neurological diseases ( NIND ) . ^^^ CSF , but not serum , anti MBP IgG levels were more frequently elevated in HIV 1+ ( 16 / 25 , 64 % ) than in MS ( 3 / 12 , 25 % ) or NIND ( 0 / 9 ) patients . ^^^ The incidence of increased CSF anti MBP IgG levels was higher among HIV 1+ patients at stage 2 3 ( 4 / 4 , 100 % ) or at stage 4 B ( 7 / 9 , 78 % ) than among those at stage 4 C 4 D ( 5 / 12 , 42 % ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In the CSF , MBP levels were essentially constant until onset of paralysis . ^^^ Although increases in MBP in the CSF were associated with the onset of radiation induced myelopathy , its assay is unlikely to predict this complication of irradiation . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Expression of IL 10 was studied in blood MNC of MS and blood and cerebrospinal fluid ( CSF ) MNC of optic neuritis ( ON ) patients without culture and after culture in the presence of myelin basic protein ( MBP ) , the control antigen acetylcholine receptor ( AChR ) , and without antigen . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Degradation of purified myelin basic protein ( MBP ) was studied by SDS gel electrophoresis after addition of CSF samples obtained from HIV 1 infected patients . ^^^ In the ADC and PML patients , in addition to CSF proteolytic activity , an increase in CSF MBP levels and presence of white matter lesions were also observed by neuroimaging ( MRI ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We have examined the potential of IL 3 , IL 5 , and granulocyte macrophage ( GM ) CSF to enhance basophil activation by eosinophil granule major basic protein ( MBP ) . ^^^ Preincubation with GM CSF similarly enhanced MBP induced histamine release . ^^^ MBP also stimulated low levels of leukotriene C 4 ( LTC 4 ) release from basophils of 84 to 99 % purity , and experiments using enriched ( 18 63 % ) basophil preparations demonstrated that preincubation with IL 3 , IL 5 , and GM CSF also potentiated MBP stimulated leukotriene C 4 release up to threefold in parallel with histamine release . ^^^ These results indicate that IL 3 , IL 5 , and GM CSF may contribute to the pathogenesis of allergic and other disorders characterized by eosinophilia in part through potentiation of basophil mediator release stimulated by MBP . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The TCR 5 gene usage and CDR3s of these MBP reactive hprt T cell clones are homologous to TCRs from other T cells relevant to MS , including T cells causing experimental allergic encephalomyelitis ( EAE ) and T cells found in brain lesions and in the cerebrospinal fluid ( CSF ) of MS patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
T cell activities to MBP and the MBP amino acid sequences 63 88 , 110 128 and 148 165 were examined by short term cultures of mononuclear cells from cerebrospinal fluid ( CSF ) and blood in the presence of these antigens , and subsequent detection and counting of antigen specific T cells that responded by interferon gamma ( IFN gamma ) secretion . ^^^ Most patients with MS and ON had MBP and MBP peptide reactive T cells in CSF , amounting to mean values of between about 1 per 2000 and 1 per 7000 CSF cells and without immunodominance for any of the peptides . ^^^ The MBP peptide recognizing T cell repertoire was different in CSF than in blood in individual patients with ON and MS , thereby giving further evidence for an autonomy of the autoimmune T cell response in the CSF compartment . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Increased synthetic peptide specificity of tissue CSF bound anti MBP in multiple sclerosis . ^^^ Synthetic peptide specificity of free anti MBP purified from MS cerebrum was identical to previously reported specificity of free anti MBP from MS cerebrospinal fluid ( CSF ) , while tissue bound anti MBP , as well as bound anti MBP from CSF had a more restricted synthetic peptide specificity than free anti MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in CSF was increased in 2 of the 3 subjects studied . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
GM CSF coeluted with the cellular fractions containing granule markers ( MBP , ECP , eosinophil peroxidase , hexosaminidase , and arylsulphatase ) , but not those containing cytoplasm ( LDH+ ) or membrane ( CD9+ ) markers . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cerebrospinal fluid ( CSF ) showed a mild elevation of both immunoglobulin G ( IgG ) and myelin basic protein ( MBP ) . ^^^ CSF IgG and MBP level showed a higher elevation than in the second episode . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The TCR 5 gene usage and CDR3s of these MBP reactive hprt T cell clones are homologous to TCRs from other T cells relevant to MS , including T cells causing experimental allergic encephalomyelitis ( EAE ) and T cells found in brain lesions and in the cerebrospinal fluid ( CSF ) of MS patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Anti MBP antibodies were found in the CSF of 16 % and in the sera of 20 % patients with MS . ^^^ MBP antibodies belonged to IgG 1 , IgG 2 and IgG 3 subclasses ( in the CSF ) and to IgG 1 and IgG 3 subclasses ( in the sera ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Cytokine production by T cells in the cerebrospinal fluid ( CSF ) and central nervous system ( CNS ) of SJL / J mice during myelin basic protein ( MBP ) induced experimental allergic encephalomyelitis ( EAE ) was examined . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
PLP , MOG and MAG reactive T cells are strongly enriched in the patients ' CSF , as previously also shown for MBP reactive T cells . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Previous research has demonstrated that free ( F ) and bound ( B ) anti myelin basic protein ( anti MBP ) can be detected in the cerebrospinal fluid ( CSF ) of patients with active multiple sclerosis ( MS ) . ^^^ Anti MBP which has previously been detected in the CSF of MS patients with active disease is also present as free antibody in the extracellular space of MS central nervous system tissue and in a smaller proportion as tissue bound antibody . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Our study was undertaken to determine if the levels of myelin basic protein ( MBP ) like material in cerebrospinal fluid ( CSF ) might indicate which patients with multiple sclerosis would show a short term ( 5 day ) or intermediate term ( 40 day ) improvement of at least a full grade Kurtzke disability score after initiating treatment with glucocorticoids . ^^^ CSF was obtained before initiation of treatment and analyzed for MBP like material by radioimmunoassay . ^^^ Individuals having a CSF MBP like material level of > or = 0 . 1 ng / ml overall showed a greater likelihood of continued improvement at day 40 ( p = 0 . 014 ) or further improvement between days 5 and 40 ( p = 0 . 003 ) . ^^^ Those in the first 15 days of worsening and with an elevated CSF MBP like level were more likely to respond by day 5 . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A double blind Phase 1 clinical research project was conducted in vivo in multiple sclerosis ( MS ) patients to determine the effect of myelin basic protein ( MBP ) synthetic peptides on free ( F ) and bound ( B ) titers of anti MBP in cerebrospinal fluid ( CSF ) . ^^^ Intravenous administration of MBP 75 95 resulted in significant decline of F and B CSF anti MBP levels over a period of one month . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The cytokine receptor homologous ( CRH ) region of the murine granulocyte colony stimulating factor ( G CSF ) receptor was secreted using a Escherichia coli maltose binding protein ( MBP ) fusion system . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Expanded CSF cells retained their capacity to respond to mitogen stimulation , but the proliferative response to myelin basic protein ( MBP ) was not enhanced . ^^^ Finally , freshly obtained CSF cells stimulated directly with MBP also expressed a limited number of 5 beta genes , although these were generally different from patterns observed following stimulation with TCGF / IL2 / IL4 . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In phase one clinical research , synthetic peptides ( p ) containing this epitope , namely pMBP 86 95 and / or pMBP 82 98 , were intrathecally administered to MS patients with monosymptomatic or polysymptomatic relapses to determine the dosage , frequency and duration of administration which will immediately neutralize F circulating CSF anti MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
NSE and MBP in the BD group were higher than those in the PVS group , thus CSF levels may be prognostic with regard to hypoxic brain injury . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The neuron specific enolase ( NSE ) , S 100 , myelin basic protein ( MBP ) and lactate levels were retrospectively analyzed in the CSF of 159 patients with various types of dementia . ^^^ The present study affirmed the strikingly high NSE and S 100 values in the CSF of patients with autopsydiagnosed Creutzfeld Jacob disease : NSE , S 100 and MBP levels in the CSF of patients with various other types of dementia , and controls , did not differ significantly . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We assessed human myelin basic protein ( MBP ) binding IgM levels in CSF . ^^^ CSF IgM anti MBP levels were assayed by measuring total IgM levels with solid phase ELISA in CSF samples from 66 patients with relapsing remitting MS , 11 subjects without neurological diseases , 20 patients with non inflammatory neurological diseases and 7 patients with lymphocytic meningitis , before and after immunoabsorption with human MBP . ^^^ Confirmation of IgM binding specificity was performed by immunoblotting of positive CSF samples onto MBP coated nitrocellulose sheets . ^^^ In this patient subgroup , IgM anti MBP levels correlated with the IgM index ( r = 0 . 71 ; P = 0 . 0001 ) , but not with CSF / serum albumin ( r = 0 . 08 ; P = 0 . 72 ) . ^^^ These findings demonstrate that in a subgroup of MS patients , elevated CSF levels of IgM anti MBP are associated with early favorable course and therefore suggest that IgM binding to MBP could be a possible prognostic marker in relapsing remitting MS to select early MS patients for future trials . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Serum and cerebrospinal fluid ( CSF ) from 20 HIV positive patients , including 14 with AIDS dementia complex ( CDC stage 4 ) and 6 asymptomatic individuals ( CDC stage 2 ) were analyzed by enzyme immunoassay for detection of antibodies to native myelin basic protein ( MBP ) and for the amino acid sequence 68 84 exposed after partial degradation of native MBP . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
METHODS : We assayed CSF mTF , TAT and myelin basic protein ( MBP ) in patients with SAH at intervals that included days 0 to 4 and days 5 to 9 after ictus . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In demyelinating pathologies , MBP concentration in the cerebrospinal fluid ( CSF ) is considered to be a good marker of demyelination . ^^^ Our technique has the same sensitivity as RIA , needs only small volumes of CSF ( 50 microliters ) and the enzyme labelled MBP tracer is stable for at least 12 months . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Tolerance induction was monitored by quantification of MBP specific autoantibodies in cerebrospinal fluid ( CSF ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) registered 24 . 3 ng / ml . ^^^ Virological examinations showed 50 fold HSV 1 IgG in serum , and MBP in the CSF was 3 . 3 ng / ml . ^^^ The MBP measurement and virological tests of the CSF and serum prove extremely important in diagnosing an ascending myelitis of unknown cause . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The presence in CSF of MS patients of a cross reactive Id to different MBP peptides is indicative of an immune response to this encephalitogenic myelin protein in a segment of MS patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Therefore , the possible use of CSF MBP , S 100 , GFAP , N CAM , NGF , and CNTF in pathogenetic studies and in clinical follow up is critically reviewed . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) or a fragment thereof may enter cerebrospinal fluid ( CSF ) and other body fluids in an etiologically nonspecific fashion to provide information about the status of central nervous system ( CNS ) myelin damage . ^^^ The dominant epitope of CSF MBPLM is in the decapeptide of 80 89 from the intact MBP molecule of 170 residues . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Serial CSF samples were collected throughout treatment and concentrations of 5 methyltetrahydrofolate ( MTF ) , methionine ( MET ) , SAM , and myelin basic protein ( MBP ) were measured . ^^^ CSF MBP mirrored SAM concentration and there was a significant inverse relationship between the two . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The CSF concentrations of TCC , myelin basic protein ( MBP ) and neurological disability correlated significantly . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Activity of the disease process in MS is accompanied by myelin breakdown and appearance of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) . ^^^ In this paper MBP in CSF of relapsing remitting ( RR ) MS patients is reviewed . ^^^ MBP in CSF is a fragment containing an epitope corresponding to amino acid residues 45 89 of the native molecule . ^^^ From several relevant studies about CSF MBP in RR MS the following relations can be concluded : CSF MBP levels in active MS patients are frequently increased ( 45 100 % ) , remain increased until 5 to 6 weeks after onset symptoms and are higher in polysymptomatic exacerbations and correlate with number of gadolinium enhanced ( Gd ) lesions on MRI , severity of relapses , EDSS score and CSF intrathecal IgM synthesis . ^^^ After an intravenous methylprednisolone treatment the increased CSF MBP levels return to normal values and reduction in CSF MBP is related to reduction in EDSS score , number of Gd lesions and CSF intrathecal IgM synthesis . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
BACKGROUND : MBPLM in different immunochemical forms is detectable in human CSF and urine , presumably a result of myelin basic protein ( MBP ) catabolism . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Assessment of the activities of the alpha and beta isoforms of conventional protein kinase C ( PKC ) , as determined by MonoQ column fractionated calcium and lipid activatible phosphotransferase activity towards myelin basic protein ( MBP ) revealed an additive effect of using LPS , IFN gamma and GM CSF , which was even greater than that demonstrated for phorbol myristate acetate ( PMA ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
To investigate peptide effects on infiltrating cells , we collected cerebrospinal fluid ( CSF ) from ( PL / JxSJL ) F 1 mice with MBP induced EAE . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The concentration of MBP in CSF also correlated positively with the CSF leukocyte count , intrathecal IgG synthesis , and the CSF serum albumin concentration quotient . ^^^ The concentration of MBP in CSF correlated negatively with intrathecal IgA synthesis . ^^^ The results support the use of the concentration of MBP in CSF as a surrogate marker of disease activity during acute exacerbations of MS ; the data also link the presence of MBP in CSF to neuroimmunological parameters . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Hematological study indicated a compensated DIC and hepatic enzyme abnormality , while the CSF examinations showed an elevation of protein and positive myelin basic protein ( MBP ) elevation . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Using a sensitive radioimmunoassay ( RIA ) , autoantibodies to myelin basic protein ( anti MBP ) can be detected in the CSF of 90 95 % of MS patients with active disease . ^^^ Between 1978 and 1998 , CSF was collected from 1 , 968 control non MS patients with psychiatric , inflammatory and noninflammatory neurological diseases as well as nonneurological systemic diseases , and anti MBP were measured by the same RIA used to detect anti MBP in MS CSF . ^^^ Anti MBP were undetectable in 98 % of CSF samples from non MS controls . ^^^ In the remaining 2 % of control samples , CSF IgGs capable of binding to MBP in vitro were unpredictably detected . ^^^ The high prevalence of free and / or bound anti MBP in the CSF of MS patients and the rare and unpredictable occurrence in the CSF of non MS patients suggest that autoimmunity to MBP may be operative in the demyelination of MS . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
There was a decrease in levels of some studied markers ( TNF in CSF , MBP level , IgG index , kappa chains in urine and kappa / creatinine ratio ) after the treatment , but the differences reached statistical significance in some groups only . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The results establish , in principle , that the same or very similar kappa light chain variable regions can be shared between CSF B lymphocytes from different individuals with MS as well as with certain antibodies against MBP . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
BACKGROUND : RIA of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) is commonly used as a biochemical marker of demyelination in patients with multiple sclerosis ( MS ) . ^^^ MBP was determined in CSF from 84 MS patients and 55 patients with other neurological diseases . ^^^ Most of the MS patients with acute exacerbations had markedly increased MBP in the CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The purpose of this Phase 1 open label clinical study was to monitor CSF anti MBP in patients with chronic progressive MS subsequent to 4 administration of synthetic peptide ( sp ) MBP 82 98 namely DEN ( 85 ) VVHFFKNIVTP ( 96 ) RT . ^^^ Fifty six patients who participated in this project were assigned to two groups : a ' control group ' of 15 patients who received 4 saline injections every 6 months for the first 2 years of the study and a ' peptide group ' of 41 patients who received 4 spMBP 82 98 from the beginning of the study and then infrequently subsequent to a rise of their CSF anti MBP . ^^^ Cohort C ( eight patients ) showed significant CSF anti MBP suppression after the initial injection but lost the ability to suppress the autoantibody titer following subsequent injections . ^^^ Cohort D ( eight patients ) failed to show significant CSF anti MBP suppression . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In the present study , EAE DC were generated from bone marrow of Lewis rats , with EAE induced with MBP 68 86 + FCA , and expanded in vitro by culture with GM CSF and IL 4 . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The initial value of myelin basic protein ( MBP ) in CSF was 0 . 9 ng / ml ( normal value : less than 4 ng / ml ) . ^^^ Subsequent measurement of MBP in CSF about two , six weeks , two , three , and six months after the onset showed a marked increase of 233 . 9 ng / ml followed by a gradual decrease of 25 . 4 ng / ml , 18 . 4 ng / ml , 7 . 4 ng / ml and 4 . 3 ng / ml , respectively . ^^^ Therefore , demyelination of the lesion in the cerebral white matter was suggested by the chronological change in FLAIR imaging and MBP in CSF . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
MBP , MOG , PLP , MAG ) , the presence of reactive T cells in blood and , further enriched , in the cerebrospinal fluid ( CSF ) , large numbers of B cells in the CSF secreting antibodies of multiple but unknown specificities , an increase of mononuclear cells ( MNC ) expressing and secreting both pro and anti inflammatory cytokines , including Th 1 cytokines interferon gamma ( IFN gamma ) and interleukin ( IL ) 6 , the Th 2 related IL 4 and IL 10 , and the Th 3 driven TGF beta , elevated numbers of MNC in both blood and CSF expressing a spectrum of metalloproteinases and their inhibitors , as well as many other aberrations . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
OBJECTIVES : To assess the concentrations of S 100 protein , myelin basic protein ( MBP ) , and lactate , and the ( CSF ) / serum albumin ratio ( Qalb ) during intracranial neurosurgical procedures . ^^^ METHODS : Samples of CSF from 91 patients with various CNS diseases were obtained by aspiration of cisternal CSF at the beginning of surgery ( before starting surgical manipulation of the brain ) and concentrations of S 100 protein , MBP , and lactate , and Qalb were determined . ^^^ Breaching of the arachnoid layer , documented at surgery for benign lesions , correlated with higher concentrations of MBP , lactate , CSF S 100 protein , and Qalb . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
However , the clinical trials should be monitored by a large set of markers of MS activity , including the estimation of anti MBP antibodies , presence of MBP material in the CSF and concentration of sVCAM 1 , ICAM 1 , PECAM 1 in CSF and serum . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In the present study , membrane bound tissue factor ( mTF ) and myelin basic protein ( MBP ) concentrations in cerebrospinal fluid ( CSF ) were evaluated as a predictor of the time of occurrence of cerebral vasospasm . ^^^ The mTF and MBP concentrations were measured in the CSF from 28 patients with SAH due to ruptured aneurysm . ^^^ CSF mTF and MBP concentrations from days 5 to 9 correlated with the volume of cerebral infarction due to vasospasm and outcome three months after SAH . ^^^ In conclusion , CSF mTF is predictive of the occurrence and the recovery of cerebral vasospasm , while CSF MBP is only an indicator of severity of brain damage due to vasospasm . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In order to define an activity profile in patients with multiple sclerosis ( MS ) , T cell subpopulations and proliferative responses to myelin basic protein ( MBP ) associated with anti MBP antibodies , nitrotyrosine levels in serum and cerebrospinal fluid ( CSF ) , and serum CD40L ( sCD 154 ) were simultaneously assessed in 29 consecutive and untreated MS patients . ^^^ In addition , in vitro specific T cell proliferative responses against MBP ( SP / A , RR / A , SP / I : p < 0 . 001 versus controls ) in association with augmented sCD 154 serum levels ( SP / A , RR / A , versus controls p < 0 . 001 ) and a significant increase of both CSF and serum levels of anti MBP antibodies and nitrotyrosine levels ( p < 0 . 001 ) were also found . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
METHODS : During 41 CSF shunt operations ( both primarily placed shunts and shunt revisions ) CSF and blood samples were obtained and analysed for neuron specific enolase ( NSE ) , S 100b , glial fibrillary acidic protein ( GFAP ) and myelin basic protein ( MBP ) . ^^^ RESULTS : We observed significantly increased CSF levels of S 100b and GFAP in the hydrocephalic patients , whereas NSE and MBP were markedly increased only in patients with very severe symptoms . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Myelin basic protein ( MBP ) in the cerebrospinal fluid ( CSF ) of MS patents is generally measured by radioimmunoassay . ^^^ We have recently established a sensitive enzyme linked immunosorbent assay ( ELISA ) and measured the MBP concentrations in CSF and serum of HAM / TSP patients . ^^^ METHODS : A sensitive two site ELISA capable of measuring MBP at a concentration as low as 30 pg / mL in serum and CSF samples was used . ^^^ RESULTS : Significantly higher CSF MBP concentrations were detected in 61 % of HAM / TSP patients than in patients with non neurological diseases . ^^^ CONCLUSIONS : Using our ELISA system , we detected MBP in CSF and serum not only in patients with central active demyelination as in MS , but also in patients with spinal cord demyelination as in HAM / TSP . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The presence of autoantibodies to the immunodominant antigen , myelin basic protein ( MBP ) , in the serum and cerebrospinal fluid ( CSF ) of patients with multiple sclerosis ( MS ) has been poorly characterized . ^^^ Autoantibodies capable of binding to MBP in the solution phase were not detected in the CSF or serum of patients with MS . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Protein S 100B , neuron specific enolase ( NSE ) , myelin basic protein ( MBP ) and glial fibrillary acidic protein ( GFAP ) in cerebrospinal fluid ( CSF ) and blood of neurological patients . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
A 2 B4O 4 injection facilitates emotional and spatial learning and memory , and pretreatment with anti acidic fibroblast growth factor ( aFGF ) antibody ICV eliminates these effects . aFGF is released from ependymal cells in the 3 cerebral ventricle in response to the glucose increase in CSF induced by 2 B4O 4 injection . 2 B4O also suppresses the clinical symptoms of experimental allergic encephalomyelitis ( EAE ) in Lewis rats [ induced by immunization with a myelin basic protein ( MBP ) ] , a model for human multiple sclerosis . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
In addition , MRI neuro electrophysiologic examination and CSF myelin basic protein ( MBP ) concentration were monitored dynamically . ^^^ The MBP levels in CSF were ( 3 . 96 + / 1 . 66 ) ng / L , and ( 2 . 25 + / 1 . 66 ) ng / L before and 3 months after the treatment . ^^^ The level of MBP in CSF can reflect the severity of the lesion and prosthetic state of myelin sheath . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The expression of myelin basic protein ( MBP ) in cerebrospinal fluid ( CSF ) , hypothalamus and hippocampus of the limbic system , and temporoparietal cortex was investigated by enzyme linked immunosorbent assay and dot blot analysis . ^^^ The MBP level was markedly increased in the CSF ( p < 0 . 01 ) in the two trauma groups , in the hypothalamus of the low speed trauma group ( p < 0 . 05 ) , and in both the hypothalamus and the hippocampus of the high speed trauma group ( p < 0 . 01 ) . ^^^ The increase of MBP content in the CSF was positively correlated with the elevation of MBP concentration in the hypothalamus and hippocampus . ^^^ Meanwhile , the MBP level in the CSF may be a sensitive biological indicator for brain damage at the early stage of trauma related stress disorder . . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Immunohistochemically , the tumor cells proved positive for S 100 , NSE , GFAP , MBP , chromogranin A and synaptophysin , and negative for CEA , keratin , HMB 45 , G CSF , and GM CSF . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Freshly isolated UCB cells were cultured with IL 3 , IL 5 and GM CSF in the presence or absence of a gamma secretase inhibitor L 685 , 458 , and examined for the expression of major basic protein ( MBP ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
The objectives of this study were ( 1 ) to determine how cerebrospinal fluid ( CSF ) neurofilament heavy chain ( NfH ( SM 134 ) and NfH ( SM 135 ) ) levels relate to clinical outcome in optic neuritis ( ON ) and multiple sclerosis ( MS ) relapse patients treated with high dose oral methylprednisolone ; and ( 2 ) to correlate neurofilament and myelin basic protein ( MBP ) concentrations , particularly as the latter was previously associated with clinical disability . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
We investigated whether serum and / or cerebrospinal fluid ( CSF ) concentrations of neuron specific enolase ( NSE ) , S100B , and myelin basic protein ( MBP ) are sensitive and specific for iTBI in high risk infants . ^^^ CONCLUSIONS : Serum and / or CSF concentrations of NSE and MBP may be useful as a screening test to identify infants who are at increased risk for iTBI and may benefit from additional evaluation with a head computed tomography scan . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Basing on their own data on the dynamics of NSP ( NSE , GFAR , and MBP ) concentrations and the proportions of these proteins in CSF and serum ( coefficient of elimination ) in rats after ischemic , hypoxic , and autoimmune cerebral lesions , the authors offer an algorithm of pathogenetic evaluation , including , on the one part , a conclusion on the presence or absence of a neurodegenerative process , and , on the other , a conclusion on a normal or lowered rate of NSP elimination ( metabolism ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
Its administration in accordance with the principle of high dose tolerance results in long term suppression of anti myelin basic protein ( MBP ) autoantibody levels in the cerebrospinal fluid ( CSF ) of a large fraction of progressive MS patients . ^^^ Anti MBP autoantibody levels in the CSF of most MBP 8298 treated patients were suppressed , but antibody suppression was not predictive of clinical benefit . ^^^ Anti MBP autoantibodies that reappeared in the CSF of one patient at 36 months , whilst under treatment with MBP 8298 , were not reactive with the MBP 8298 peptide in vitro . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
METHOD : We investigated CSF and serum samples from 12 patients with first onset schizophrenia and from 17 control subjects by ELISA ( GFAP , MBP ) or immunoluminometric sandwich assays ( NSE , S100B ) . ^^^
Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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Interacting proteins: P13727 and P04141	Pubmed	SVM Score :0.0
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