| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| A novel ligand of the formyl peptide receptor : annexin 1 regulates neutrophil extravasation by interacting with the FPR . ^^^ Here we show that annexin 1 acts through the formyl peptide receptor ( FPR ) on human neutrophils . ^^^ Peptides derived from the unique N terminal domain of annexin 1 serve as FPR ligands and trigger different signaling pathways in a dose dependent manner . ^^^ These findings identify annexin 1 peptides as novel , endogenous FPR ligands and establish a mechanistic basis of annexin 1 mediated antiinflammatory effects . . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| In a model of mouse peritonitis , FPR antagonists abrogated the anti migratory effects of peptides Ac 2 26 and Ac 2 12 , with a partial reduction in annexin 1 effects . ^^^ Binding of annexin 1 to circulating leukocytes was reduced ( > 50 % ) in FPR KO mice . ^^^ Finally , evidence of direct annexin 1 binding to murine FPR was obtained with HEK 293 cells transfected with the receptor . ^^^ Overall , these results indicate a functional role for FPR in the anti migratory effect of annexin 1 and derived peptides . . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| We examined the 1 ) amino acid region of ANXA 1 that retained the protective effect in a model of rat heart IR ; 2 ) changes in endogenous ANXA 1 in relation to the IR induced damage and after pharmacological modulation ; and 3 ) potential involvement of the formyl peptide receptor ( FPR ) in the protective action displayed by ANXA 1 peptides . ^^^ Finally , an antagonist to the FPR receptor selectively inhibited the protective action of peptide ANXA 1 and its derived peptides against IR injury . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| Activation of the FPR in A 549 cells can not only be triggered by fMLP , but also by an agonistic peptide of the recently identified endogenous FPR ligand , annexin 1 . ^^^ In addition to inducing changes in the F actin content , annexin 1 mediated triggering of the FPR results in an increased expression of acute phase proteins . ^^^ Hence , activation of nonmyeloid FPR by its endogenous ligand annexin 1 could participate in the regulation of acute phase responses , e . g . , during inflammation and / or wound healing . . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| Leukocyte antiadhesive actions of annexin 1 : ALXR and FPR related anti inflammatory mechanisms . ^^^ Recent investigations conducted with human neutrophils have indicated an involvement for the receptor for formylated peptides , termed FPR , and its analog FPRL 1 ( or ALXR because it is the receptor for the endogenous ligand lipoxin A ( 4 ) ) in the in vitro inhibitory actions of the glucocorticoid regulated protein annexin 1 and its peptidomimetics . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| In this study we show that a peptide derived from the N terminal domain of the anti inflammatory protein annexin 1 ( lipocortin 1 ) can activate all three FPR family members at similar concentrations . ^^^ The annexin 1 peptide initiates chemotactic responses in human monocytes that express all three FPR family members and also desensitizes the cells toward subsequent stimulation with bacterial peptide agonists . ^^^ Experiments using HEK 293 cells stably expressing a single FPR family member reveal that all three receptors can be activated and desensitized by the N terminal annexin 1 peptide . ^^^ These observations identify the annexin 1 peptide as the first endogenous ligand of FPRL 2 and indicate that annexin 1 participates in regulating leukocyte emigration into inflamed tissue by activating and desensitizing different receptors of the FPR family . . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| Recent interest in the annexin 1 field has come from the notion that specific G protein coupled receptors , members of the formyl peptide receptor ( FPR ) family , appear to mediate the anti inflammatory actions of this endogenous mediator . ^^^ Similarly , peptide Ac 2 26 inhibition of specific markers of heart injury ( specifically myeloperoxidase activity , CXC chemokine KC contents , and endogenous annexin 1 protein expression ) was virtually identical in heart samples collected from wild type and FPR null mice . ^^^ Thus , this study sheds light on the receptor mechanism ( s ) mediating annexin 1 induced cardioprotection and shows a pivotal role for ALX and circulating neutrophil , whereas it excludes any functional involvement of mouse FPR . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| ANXA 1 and its peptide act via the FPR family of receptors . ^^^ While Ac 2 26 bound both FPR and FPRL 1 / ALX , ANXA 1 bound FPRL 1 / ALX only . ^^^ ANXA 1 and Ac 2 26 acted as genuine agonists ; Ac 2 26 binding led to ERK activation in both FPR and FPRL 1 / ALX transfected cells , while ANXA 1 caused ERK activation only in cells transfected with FPRL 1 / ALX . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| Because extracellular AnxA 1 has been shown to regulate leukocyte migratory events through interactions with n formyl peptide receptors ( nFPRs ) , we examined the expression of FPR 1 , FPRL 1 , and FPRL 2 in SKCO 15 cells by reverse transcriptase PCR and identified expression of all three receptors in this cell line . ^^^ |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P21462 and P04083 |
Pubmed |
SVM Score :0.0 |
| NA |
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