| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :1.1452759 |
| Indeed , annexin 1 and annexin 2 have been identified as major substrates for the tyrosine kinase activity associated with epidermal growth factor receptor ( EGF R ) and for the retrovirus encoded protein tyrosine kinase pp60v arc . 1.1452759^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of lipocortin 1 by the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Ontogeny of epidermal growth factor receptor and lipocortin 1 in fetal and neonatal human lungs . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Annexin 6 ( p 68 , 67 kDa calelectrin ) is a member of a family of Ca2+ / phospholipid binding proteins , that includes p 35 ( annexin 1 ) and p 36 ( annexin 2 ) , the major cellular substrates for phosphorylation by the epidermal growth factor receptor and pp60v src tyrosine kinase activities , respectively . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| We used a density shift technique to isolate MVBs and show that the major substrates phosphorylated in vitro within MVBs which contain an active EGF R kinase are the EGF R itself and annexin 1 . ^^^ In cells with an active EGF R kinase the amount of calcium independent annexin 1 in MVBs is reduced , suggesting that a phosphorylation induced conversion of the calcium independent to the calcium dependent form also occurs in vivo . ^^^ Our observations , together with the known properties of annexin 1 in mediating membrane fusion , suggest that inward vesiculation in MVBs is induced by the EGF R and is mediated by phosphorylated annexin I . . ^^^ Annexin 1 is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Although annexin 1 has been described as a major in vitro substrate of both protein kinase C and the epidermal growth factor receptor protein tyrosine kinase , the functional consequences of these phosphorylation events have not been investigated . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| These results suggest that an enzyme or enzymes other than protein kinase C , epidermal growth factor receptor kinase , or insulin receptor kinase is responsible for the GT1b and GD 3 enhanced phosphorylation of annexin 1 in the presence of PS and Ca2+ . . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Annexin 1 is a Ca ( 2+ ) regulated membrane binding protein and a major substrate of the epidermal growth factor receptor kinase . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Deletion of annexin 1 , a substrate of EGFR tyrosine kinase , abolishes the effect of EGF stimulation on inward vesiculation . ^^^ Loss or depletion of annexin 1 has no effect on EGF degradation and causes only a small delay in EGFR degradation , indicating that annexin 1 operates downstream of Hrs and ESCRT mediated sorting and is required solely for EGF stimulated inward vesiculation . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Antibodies to the N terminus of calpactin 2 ( p 35 ) affect Ca2+ binding and phosphorylation by the epidermal growth factor receptor in vitro . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| One of these proteins ( calpactin 1 ) appears identical to the Mr 34 , 000 39 , 000 substrate of the pp60src tyrosine kinase and the second ( calpactin 2 ) reacts with antibodies to the Mr 35 , 000 substrate of the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Lipocortin 1 is a steroid induced , calcium regulated membrane binding protein ( Mr = 39 , 000 ) which is a substrate for the epidermal growth factor receptor kinase in intact cells . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| The dexamethasone induced block of Grb 2 recruitment was parallelled by changes in phosphorylation status and subcellular localization of lipocortin 1 ( LC 1 ) and an increase in the amount of the tyrosine phosphoprotein co localized with EGF R . ^^^ |
|
| Interacting proteins: P04083 and P00533 |
Pubmed |
SVM Score :0.0 |
| Thus , ANX 1 expression and phosphorylation could be a factor implicated in liver regeneration and tumorigenesis , either through modulation of cPLA ( 2 ) activity or EGF R function . . ^^^ |
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