| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.73968571 |
| The identification of Hsp / Hsc70 as a partner protein for BAG 1 may explain the diverse interactions observed between BAG 1 and several other proteins , including Raf 1 , steroid hormone receptors and certain tyrosine kinase growth factor receptors . 0.73968571^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.77256387 |
| Since there appears to exist an equilibrium within the cell between BAG 1 binding to heat shock protein 70 ( Hsp 70 ) and BAG 1 binding to Raf 1 kinase , we hypothesized that changing BAG 1 binding characteristics might significantly alter BAG 1 function . 0.77256387^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 interacting protein , BAG 1 , binds to and activates the kinase Raf 1 . ^^^ Like BAG 1 , the serine / threonine protein kinase Raf 1 also can functionally cooperate with Bcl 2 in suppressing apoptosis . ^^^ Here we show that Raf 1 and BAG 1 specifically interact in vitro and in yeast two hybrid assays . ^^^ Raf 1 and BAG 1 can also be coimmunoprecipitated from mammalian cells and from insect cells infected with recombinant baculoviruses encoding these proteins . ^^^ Furthermore , bacterially produced BAG 1 protein can increase the kinase activity of Raf 1 in vitro . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| These mutants also fail to bind to BAG 1 and Raf 1 , two proteins that we have shown can associate with protein complexes containing Bcl 2 and which cooperate with Bcl 2 to suppress cell death . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| The expression and function of the newly identified Bcl 2 and Raf 1 binding protein , Bag 1 , during the cytokine regulated growth of B and T cell lines was examined . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| The BAG 1 protein appears to inhibit cell death by binding to Bcl 2 , the Raf 1 protein kinase , and certain growth factor receptors , but the mechanism of inhibition remains enigmatic . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is a multifunctional protein that blocks apoptosis and interacts with several types of proteins , including Bcl 2 family proteins , the kinase Raf 1 , certain tyrosine kinase growth factor receptors , and steroid hormone receptors , possibly by virtue of its ability to regulate the Hsp70 / Hsc70 family of molecular chaperones . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| Moreover , a Bcl 2 binding protein , BAG 1 , was shown to not only bind Raf 1 , but also increase the activity of this kinase through a protein protein interaction . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is a Hsp70 / Hsc70 binding protein that interacts with Bcl 2 , Raf 1 , steroid hormone receptors , Siah 1 , and hepatocyte growth factor ( HGF ) receptors , implying multiple functions for the BAG 1 protein . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is an anti apoptotic protein that interacts with Bcl 2 , Bcl XL , Hsp70 / Hsc70 , Raf 1 and numerous hormone or growth factor receptors . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| Given its proposed involvement in multiple cell signaling events as a regulator of Raf 1 , Bcl 2 , or androgen receptor , we wondered whether Bag 1 functions in vivo as a negative regulator of Hsp 70 . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have generated mice heterozygous for BAG 1 , carrying a BAG 1 null allele , that in addition express oncogenic , constitutively active C Raf kinase ( SP C C Raf BxB ) in type 2 pneumocytes . ^^^ RESULTS : We show that BAG 1 heterozygosity in mice impairs C Raf oncogene induced lung adenoma growth . ^^^ Lung tumor initiation was reduced by half in BAG 1 heterozygous SP C C Raf BxB mice compared to their littermates . ^^^ |
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| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| Bag 1 is a cochaperone for the heat shock protein Hsp 70 that interacts with C Raf , B Raf , Akt , Bcl 2 , steroid hormone receptors and other proteins . ^^^ |
|
| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is a co chaperone that regulates the activity of Hsp 70 , Bcl 2 , Raf 1 , growth factor , and steroid receptors ( e . g . , the Androgen Receptor ) . ^^^ |
|
| Interacting proteins: Q99933 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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