| Interacting proteins: Q99683 and P04049 |
Pubmed |
SVM Score :0.0 |
| Simultaneous treatment with 4 hydroxy 2 , 2 , 6 , 6 tetramethyl piperidinoxyl ( Tempol ) , a membrane permeable radical scavenger , completely eliminated the increases of phosphorylated MAP kinases and their upstream elements ( Raf 1 , Rac 1 , ASK 1 ) as well as the increases of cardiac lipid peroxidation induced by the highest dose of ISO infusion . ^^^ |
|
| Interacting proteins: Q99683 and P04049 |
Pubmed |
SVM Score :0.0 |
| The DVD sites bind to their specific upstream MAP kinase kinase kinases ( MAPKKKs ) , including MTK 1 ( MEKK 4 ) , ASK 1 , TAK 1 , TAO 2 , MEKK 1 , and Raf 1 . ^^^ |
|
| Interacting proteins: Q99683 and P04049 |
Pubmed |
SVM Score :0.0 |
| Apoptosis linked gene 2 connects the Raf 1 and ASK 1 signalings . ^^^ Importantly , Raf 1 blocks the ASK 1 dependent ALG 2 phosphorylation . ^^^ Since ALG 2 associates with ASK 1 , and both ASK 1 and ALG 2 are involved in apoptosis , our observations indicate that Raf 1 may mediate its anti apoptotic function by interrupting ASK 1 dependent phosphorylation of ALG 2 . . ^^^ |
|
| Interacting proteins: Q99683 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|