| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Because the 14 3 3 family of proteins could interact with key signaling proteins including Raf 1 kinase , protein kinase C , and phosphatidyl inositol 3 kinase , whereas P 11 is an early response gene induced by the neuronal survival factor , nerve growth factor , the present findings suggest that BAD plays an important role in mediating communication between different signal transduction pathways regulated by hormonal signals and the apoptotic mechanism controlled by Bcl 2 family members . . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove . 14 3 3 proteins bind a variety of molecules involved in signal transduction , cell cycle regulation and apoptosis . 14 3 3 binds ligands such as Raf 1 kinase and Bad by recognizing the phosphorylated consensus motif , RSXpSXP , but must bind unphosphorylated ligands , such as glycoprotein Ib and Pseudomonas aeruginosa exoenzyme S , via a different motif . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Targeting Raf 1 ( Cat ) to mitochondrial membranes by fusing with the transmembrane domain of an outer mitochondrial membrane protein protected cells from apoptosis and resulted in phosphorylation of BAD protein , whereas plasma membrane targeted Raf 1 failed to phosphorylate BAD and did not protect against cell death . ^^^ The findings suggest that Bcl 2 targets Raf 1 to mitochondria , allowing this kinase to contribute to cellular survival by phosphorylating BAD or possibly other protein substrates in the vicinity of Bcl 2 . . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAD enables ceramide to signal apoptosis via Ras and Raf 1 . ^^^ Ceramide signaled apoptosis in BAD expressing cells by a pathway involving sequentially kinase suppressor of Ras ( KSR ) / ceramide activated protein kinase , Ras , c Raf 1 , and MEK 1 . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| By contrast , suppression of mitochondrial Raf 1 enzymatic activity by expression of a mitochondria targeted Raf 1 dominant negative mutant rendered Akt expressing cells susceptible to apoptosis induced by growth factor deprivation and was accompanied by inhibition of BAD , but not mitogen activated protein kinase , phosphorylation . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| In addition , alpha synuclein binds to 14 3 3 proteins , as well as some proteins known to associate with 14 3 3 , including protein kinase C , BAD , and extracellular regulated kinase , but not Raf 1 . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| These findings taken together , suggest that the loss of tropic hormone support is translated into the attenuation of Raf 1 MEK ERK signaling pathway and this reduction along with a reduction in the levels of phosphorylated form of Bad triggers the onset of apoptosis in the ovarian granulosa cells . . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Ras by exoenzyme S . 14 3 3 proteins play a regulatory role and participate in both signal transduction and checkpoint control pathways . 14 3 3 proteins bind phosphoserine ligands , such as Raf 1 kinase and Bad , by recognizing the phosphorylated consensus motif , Arg Ser Xaa pSer Xaa Pro ( where ' Xaa ' represents ' any residue ' , and ' pSer ' is ' phosphoserine ' ) . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Here we report that multiple isoforms of 14 3 3 proteins were capable of binding to several ligands , Bad , Raf 1 , and Cbl . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| C Raf cooperates with Bcl 2 / Bcl XL in suppression of apoptosis by a mechanism that involves targeting of C Raf to the outer mitochondrial membrane and inactivation of the pro apoptotic protein Bad . ^^^ However , apoptosis suppression by C Raf also occurs in cells lacking expression of Bad or Bcl 2 . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Inhibition of phosphorylation of BAD and Raf 1 by Akt sensitizes human ovarian cancer cells to paclitaxel . ^^^ We studied the roles of the phosphatidylinositol 3 kinase ( PI 3K ) Akt BAD cascade , ERK BAD cascade , and Akt Raf 1 cascade in the paclitaxel resistant SW 626 human ovarian cancer cell line , which lacks functional p 53 . ^^^ Our findings suggest that paclitaxel induces the phosphorylation of BAD Ser 112 via the ERK cascade , and the phosphorylation of both BAD Ser 136 and Raf 1 Ser 259 via the PI 3K Akt cascade , and that inhibition of either of these cascades sensitizes ovarian cancer cells to paclitaxel . . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Exoenzyme S binds its cofactor 14 3 3 through a non phosphorylated motif . 14 3 3 proteins belong to a family of conserved molecules , which play a regulatory role and participate in signal transduction and checkpoint control pathways . 14 3 3 proteins bind phosphoserine phosphorylated ligands , such as the Raf 1 kinase and Bad , through recognition of the phosphorylated consensus motif , RSXpSXP ( where pS is phosphoserine ) . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| A truncated form of 14 3 3zeta lacking this C terminal loop was generated and found to bind with higher affinity than the wild type 14 3 3zeta protein to the ligands Raf 1 and Bad . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Mitochondrial increase of Bad protein is coincident with a transient decrease of the active , phosphorylated form of prosurvival kinase , Raf 1 , under conditions of long reperfusion . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| Kinase 1 ( Pak 1 ) dependent phosphorylation of Raf 1 regulates its mitochondrial localization , phosphorylation of BAD , and Bcl 2 association . ^^^ Raf 1 protects cells from apoptosis , independently of its signals to MEK and ERK , by translocating to the mitochondria where it binds Bcl 2 and displaces BAD . ^^^ Here we elucidate the molecular mechanism through which Pak 1 signals to BAD through a Raf 1 activated pathway . ^^^ Upon phosphorylation by Pak 1 , Raf 1 translocates to mitochondria and phosphorylates BAD at Ser 112 . ^^^ Notably , we show that formation of a Raf 1 Bcl 2 complex coincides with loss of an interaction between Bcl 2 and BAD . ^^^ |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92934 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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