| Interacting proteins: Q13322 and P04049 |
Pubmed |
SVM Score :0.7289776 |
| Localization of endogenous Grb 10 to the mitochondria and its interaction with the mitochondrial associated Raf 1 pool . 0.7289776^^^ We have recently demonstrated that the Grb 10 SH2 domain interacts with both the Raf 1 and MEK 1 kinases . 0.66635048^^^ |
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| Interacting proteins: Q13322 and P04049 |
Pubmed |
SVM Score :0.52572613 |
| In addition to receptor tyrosine kinases , Grb 10 has also been found to interact with non receptor tyrosine kinases such as Tec and Bcr Abl , other cellular signaling molecules such as Raf 1 , and the mitogen activated protein ( MAP ) kinase , MEK . 0.52572613^^^ |
|
| Interacting proteins: Q13322 and P04049 |
Pubmed |
SVM Score :0.0 |
| Interaction of the Grb 10 adapter protein with the Raf 1 and MEK 1 kinases . ^^^ Interaction of Grb 10 with Raf 1 is constitutive , while interaction between Grb 10 and MEK 1 needs insulin treatment of the cells and follows mitogen activated protein kinase activation . ^^^ |
|
| Interacting proteins: Q13322 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have combined PCR mutagenesis and a two hybrid mating assay to produce a screening strategy that has already proven useful in isolating ligand specific mutants of the Grb 10 and Raf 1 signaling proteins . . ^^^ |
|
| Interacting proteins: Q13322 and P04049 |
Pubmed |
SVM Score :0.0 |
| In addition to receptor tyrosine kinases , Grb 10 has also been found to interact with non receptor tyrosine kinases such as Tec and Bcr Abl , and other cellular signaling molecules such as Raf 1 and the mitogen activated protein ( MAP ) kinase kinase , MEK . ^^^ |
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