| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Raf 1 by p 21 activated kinase 1 and Src regulates Raf 1 autoinhibition . ^^^ |
|
| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| PAK 1 phosphorylates MEK 1 on Ser 298 , a site important for binding of Raf 1 to MEK 1 in vivo . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| PAK 1 and Src kinases phosphorylate specific serine and tyrosine residues within the activation loop of Raf 1 kinase . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Addition of specific protein kinase inhibitors , many of which shared the ability to influence the activity of the STKs p 21 activated kinase 1 ( PAK 1 ) and Raf 1 attenuated MV replication in permissive 3T3 cells . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Here we show that expression of active Ras , Raf 1 , or Rac 1 in fibroblasts stimulates NFkappaB in a PAK 1 dependent manner and that expression of active PAK 1 can stimulate NFkappaB on its own . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Furthermore , integrin induced activation of the serine / threonine kinase Pak 1 , which has been shown to phosphorylate Raf 1 Ser338 , was also dependent on PI 3 kinase activity and expression of a kinase inactive Pak 1 mutant blocked phosphorylation of Raf 1 Ser338 . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Interaction between active Pak 1 and Raf 1 is necessary for phosphorylation and activation of Raf 1 . ^^^ The present study explores the structural basis of Raf 1 phosphorylation by Pak 1 . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| PAK 1 primes MEK 1 for phosphorylation by Raf 1 kinase during cross cascade activation of the ERK pathway . ^^^ Here we show that both Raf 1 and MEK 1 are phosphorylated by PAK 1 and that mutations at PAK 1 phosphorylation sites in either protein prevent cross cascade activation . ^^^ In contrast , MEK 1 activation by constitutively active Raf 1 is refractory to mutations at PAK 1 phosphorylation sites . ^^^ Our findings indicate that PAK 1 primes MEK 1 for activation by Raf 1 and imply another level of regulation in the ERK cascade . . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Using genomic microarray , we detected oncogene copy number gains of RAF 1 ( 3p25 ) , CTSB ( 8p22 ) , PAK 1 ( 11q13 ) , and JUNB ( 19p13 ) in 5 of 7 cases of mycosis fungoides ( MF ) / Sezary syndrome ( SS ) ( 71 % ) , gains of FGFR 1 ( 8p11 ) , PTPN ( 20q13 ) , and BCR ( 22q11 ) in 4 cases ( 57 % ) , and gains of MYCL 1 ( 1p34 ) , PIK3CA ( 3q26 ) , HRAS ( 11p15 ) , MYBL 2 ( 20q13 ) , and ZNF 217 ( 20q13 ) in 3 cases ( 43 % ) . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Here , we show that basic fibroblast growth factor ( bFGF ) and vascular endothelial growth factor ( VEGF ) differentially activate Raf , resulting in protection from distinct pathways of apoptosis in human endothelial cells and chick embryo vasculature . bFGF activated Raf 1 via p 21 activated protein kinase 1 ( PAK 1 ) phosphorylation of serines 338 and 339 , resulting in Raf 1 mitochondrial translocation and endothelial cell protection from the intrinsic pathway of apoptosis , independent of the mitogen activated protein kinase kinase 1 ( MEK 1 ) . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Genomic microarray analysis identified oncogene copy number gains of PAK 1 and JUNB in three of four cases studied , and gains of RAF 1 , CTSB , FGFR 1 , and BCR in two cases . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| However , unlike Raf 1 , the phosphorylation of B Raf at Ser ( 445 ) was constitutive and was only moderately increased by expression of constitutively active H Ras or constitutively active PAK 1 . ^^^ |
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| Interacting proteins: Q13153 and P04049 |
Pubmed |
SVM Score :0.0 |
| Kinase 1 ( Pak 1 ) dependent phosphorylation of Raf 1 regulates its mitochondrial localization , phosphorylation of BAD , and Bcl 2 association . ^^^ Here we elucidate the molecular mechanism through which Pak 1 signals to BAD through a Raf 1 activated pathway . ^^^ Upon phosphorylation by Pak 1 , Raf 1 translocates to mitochondria and phosphorylates BAD at Ser 112 . ^^^ These signals are specific for Pak 1 , because Src activated Raf 1 only stimulates the MAP kinase cascade . ^^^ Thus , our data identify the molecular connections of a Pak 1 Raf 1 BAD pathway that is involved in cell survival signaling . . ^^^ |
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