| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Given its proposed involvement in multiple cell signaling events as a regulator of Raf 1 , Bcl 2 , or androgen receptor , we wondered whether Bag 1 functions in vivo as a negative regulator of Hsp 70 . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Raf 1 , heat shock protein 70 ( HSP 70 ) , and HSP 90 in tissues were determined by Western blotting . ^^^ HSP 70 was undetectable in livers of vehicle treated mice or mice killed at 2 or 4 h after 17DMAG treatment , but was detected in livers at 7 , 24 and 48 h . 17DMAG did not affect renal Raf 1 . ^^^ Raf 1 , HSP 90 , and HSP 70 were altered to different degrees in tumors , livers , and kidneys of 17DMAG treated animals . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| These events were associated with increased binding of Bcr Abl , Raf 1 , and Akt to Hsp 70 , and inactivation of extracellular signal regulated kinase 1 / 2 and Akt . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Since there appears to exist an equilibrium within the cell between BAG 1 binding to heat shock protein 70 ( Hsp 70 ) and BAG 1 binding to Raf 1 kinase , we hypothesized that changing BAG 1 binding characteristics might significantly alter BAG 1 function . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| By activating anti apoptotic factors ( e . g . , Hsp 70 , Raf 1 , Bcl xL ) , Bcr Abl blocks apoptotic pathways at multiple levels , thus rendering leukemia cells resistant to chemotherapeutic agents such as doxorubicin ( DOX ) . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Bag 1 is a cochaperone for the heat shock protein Hsp 70 that interacts with C Raf , B Raf , Akt , Bcl 2 , steroid hormone receptors and other proteins . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Cellular markers of heat shock protein ( Hsp ) 90 inhibition , Hsp 70 induction , and Raf 1 degradation were measured by immunoblot analysis . ^^^ Marked Hsp 70 induction and Raf 1 degradation was observed in MDA468 / NQ16 cells but not in MDA 468 cells . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Treatment with 17 AAG attenuated the levels of phospho AKT , AKT , and c Raf but increased hsp 70 levels to a similar extent in the control HL 60 / Neo and HL 60 / hsp70 cells . ^^^ This was associated with decreased binding of Bax to hsp 70 and increased 17 AAG induced Bax conformation change . 17 AAG mediated decline in the levels of AKT , c Raf , and Bcr Abl was similar in K 562 and K562 / siRNA hsp 70 cells . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is a co chaperone that regulates the activity of Hsp 70 , Bcl 2 , Raf 1 , growth factor , and steroid receptors ( e . g . , the Androgen Receptor ) . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Hsp 90 client proteins affected by the inhibition of F ( 1 ) F ( 0 ) ATP synthase included ERalpha , mutated p 53 ( m . p53 ) , Hsp 70 , Hsp 27 , and caspase 3 but not Raf 1 . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Heretofore , the biomarkers to detect 17 AAG bioactivity ( Hsp 70 , Raf 1 , and cyclin dependent kinase 4 ) had to be analyzed by Western blot of cellular samples , either from tumor biopsies or peripheral blood leukocytes , a method that is both laborious and invasive . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| In addition , deletion of Hsp 70 genes might induce cardiac dysfunction and development of cardiac hypertrophy through the activation of JNK , p 38 MAPK , Raf 1 , and ERK . . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| Pharmacodynamic endpoints , such as induction of HSP 70 and downregulation of C RAF and CDK 4 in peripheral blood mononuclear cells and tumor biopsies from treated patients , provided evidence of HSP 90 inhibition at well tolerated doses . ^^^ |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34932 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|