| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| This activation was mediated by the interaction of Ang 2 with the AT 1 , receptor subtype and was associated with the redistribution of AT 1 receptor with Ras and Raf 1 on the neuronal membrane . ^^^ These results suggest that AT 1 receptors are coupled to a Ras Raf 1 mitogen activated protein kinase signal transduction pathway that is responsible for stimulation of NET and TH , two neuro modulatory actions of Ang 2 in the brain . . ^^^ |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| Thus , the AT 1 receptor signals through Raf 1 and its downstream signaling molecules by a PKC dependent mechanism that does not involve Ras activation . . ^^^ |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| AT 1 receptor mediated nuclear translocation of Raf 1 in brain neurons . ^^^ Angiotensin 2 ( Ang 2 ) interacts with the neuronal AT 1 receptor subtype and initiates a cascade of signaling events involving activation of Ras Raf 1 MAP kinase . ^^^ The nuclear sequestration of Raf 1 was blocked by losartan , an AT 1 receptor specific antagonist , and not by PD 123319 , an AT 2 receptor specific antagonist . ^^^ |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| AT 1 receptor mediated regulation of certain signaling events ( such as activation of the Ras Raf 1 mitogen activated protein ( MAP ) kinase signaling pathway , nuclear translocation of transcription factors such as Fos and Jun , and the interactions of these factors with AP 1 binding sites ) is involved in this NE neuromodulation ( Lu et al . ^^^ |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| We therefore examined the pathways by which angiotensin 2 ( Ang 2 ) activates Raf 1 kinase , an upstream intermediate in the pathway to MAPK , via the Gq coupled AT 1 angiotensin receptor in bovine adrenal glomerulosa ( BAG ) cells . ^^^ Ang 2 was a potent stimulus of Raf 1 activation with an ED 50 of 10 pM and a maximal response at 1 nM , although higher Ang 2 concentrations elicited a submaximal response . ^^^ |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30556 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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