| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| Interleukin 2 ( IL 2 ) induces tyrosine kinase dependent translocation of active raf 1 from the IL 2 receptor into the cytosol . ^^^ Herein , we report that enzymatically active Raf 1 is physically associated with the IL 2 receptor beta chain ( p 75 ) in T cell blasts . ^^^ Following stimulation with IL 2 , Raf 1 dissociates from the IL 2 receptor complex and translocates to the cytosol . ^^^ Genistein , a protein tyrosine kinase inhibitor , prevents the dissociation of enzymatically active Raf 1 from the ligand stimulated IL 2 receptor complex . ^^^ These data favor a model of IL 2 receptor activation in which an IL 2 activated protein tyrosine kinase phosphorylates the IL 2 receptor and / or receptor bound Raf 1 . ^^^ |
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| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| The results further demonstrate the unique nature of lpr derived T cells and show that 1 ) all lines and clones exhibit greatly elevated expression of both the c myb and the c raf oncogenes , 2 ) despite the reported defect in IL 2 receptor expression of mitogen activated fresh MRL lpr / lpr T cells , all long term lines or clones bear large numbers of IL 2 receptors continuously and without stimulation , although 3 ) unlike slower growing IL 2 dependent lines from MRL lpr / lpr mice , these rapidly growing lines and clones are poorly inhibited by anti IL 2 receptor antibody . ^^^ |
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| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have examined the role of Raf 1 in the mitogenic response of human peripheral blood derived IL 2 receptor expressing T cells to human recombinant IL 2 employing c raf antisense ( AS ) oligodeoxyribonucleotide . ^^^ |
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| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| Interleukin 2 receptor signal transduction : translocation of active serine threonine kinase Raf 1 from IL 2 receptor into cytosol depends on IL 2 induced tyrosine kinase activation . ^^^ |
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| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14784 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|