| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.96639262 |
| Analysis of the Ras signalling complexes in immunoprecipitates from Ha ras transformed cells revealed that Raf 1 co immunoprecipitated with endogenous c N ras but not ( G12V ) Ha ras . 0.96639262^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| The expression of nine proto oncogenes ( c myc , N myc , c fos , c jun , p 53 , H ras , N ras , c raf , hst ) and other three genes ( AFP , PCNA , GST P ) were investigated during spontaneous development to hepatocellular carcinomas ( HCCs ) in LEC rats . ^^^ Expressions of c myc , H ras , N ras , c raf , p 53 , and PCNA genes were detected but did not significantly change during the development to HCCs in LEC rats . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| In addition , NAB 2 cells have two other consistent translocations : a 1 ; 5 ( p 22 ; q 23 ) and a 3 ; 7 ( p 25 ; q 22 ) , with breakpoints close to the location of N ras , fms , and raf 1 protooncogenes , respectively . ^^^ In situ hybridization with myc , N ras , and raf 1 radiolabeled DNA probes to NAB 2 chromosomes showed that none of these genes was relocated as a result of translocation . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Expression of the N ras oncogene in embryo fibroblast NIH / 3T3 cells has been demonstrated to increase radioresistance in vitro , and these results have been confirmed and extended to human cell lines expressing the c raf oncogene . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have studied the expressions of nine proto oncogenes ( c myc , N myc , c fos , C jun , p 53 , H ras , N ras , c raf , hst ) and two other genes ( PCNA , GST P ) during the spontaneous development of hepatocellular carcinomas ( HCCs ) in LEC rats . ^^^ Expression of c myc , H ras , N ras , C raf , p 53 and PCNA genes was detected , but this did not significantly change during the development of HCCs in LEC rats . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Expression of the proto oncogenes c myc , p 53 , c jun , pim 1 , lck , c syn , c raf and N ras were detected in Hodgkin ' s disease derived cell lines and in normal hematopoietic cells . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Permanent conversion of NIH3T3 cells transformed by activated c Ha ras , c Ki ras , N ras , or c raf , and of human pancreatic adenocarcinoma containing activated c Ki ras to apparently normal cells by treatment with the antibiotic azatyrosine . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the expression of 12 protooncogenes , c Ha ras , c Ki ras , N ras , c myc , N myc , c fos , c abl , c fes , c fms , c raf , c erbB 1 , and c erbB 2 , in tissues of human renal cell carcinomas and in adjacent normal kidneys . ^^^ Although N ras , c fos , and c raf gene transcripts were detected in both malignant and normal tissues , differences in these protooncogene expressions were not found between the carcinomas and normal kidneys . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Lod scores for close linkage of each candidate sequence to breast cancer were 19 . 6 for HRAS , 12 . 3 for KRAS 2 , 1 . 0 for NRAS , 6 . 0 for MYC , 6 . 1 for MYB , 8 . 2 for ERBA 2 , 7 . 9 for INT 2 , and 5 . 1 for RAF 1 . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Treatment with azatyrosine caused similar conversion of NIH 3T3 cells transformed by activated c Ki ras , N ras , or c raf to apparently normal cells , but NIH 3T3 cells transformed by hst or ret were not exclusively converted by azatyrosine . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Analysis of cellular oncogenes showed that myc and fps were amplified approximately tenfold and threefold , respectively , in this cell line , whereas N myc , L myc , N ras , K ras , H ras , abl , erbB 2 , Blym , src , raf 1 , myb , and sis were not changed significantly . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| This location demonstrates that Dsi 1 is different from 16 of the known proto oncogenes ( c abl , c erbA c erbB , c ets 1 , c ets 2 , c fes , c fos , c myb , c myc , c raf , A raf , c Ha ras , c Ki ras , N ras , c sis , and c src ) and 12 cellular regions of tumor associated integrations in retrovirus induced tumors ( c erbB , Fis 1 , int 1 , int 2 , Mis 1 / pvt 1 , Mlvi 1 , Mlvi 2 , c mos , c myb , c myc , Pim 1 , and c Ha ras ) . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Four protooncogenes ( c fos , c abl , N ras , and c raf ) were expressed at low levels in both steps of erythroleukemia . c fos and c abl RNAs were barely detectable in normal erythroid cells . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| We have analysed the c myc , c jun , c raf and N ras and p 53 expression in total RNA preparation from tumor biopsies obtained before treatment . ^^^ No significant differences in c raf and N ras expression were found in responding or resistant patients . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| DNA probes for the NRAS , HRAS , KRAS 2 , LCK , RAF 1 , MET , MYCL 1 , MYCN , MYB , ERBB 2 , FOS , CSF1R , and SRC protooncogene loci ; the retinoblastoma gene locus ( RB 1 ) ; the tumor virus integration sites INT 2 , PVT 1 , and MLV 12 ; and the locus of the tumor specific antigen T1A were used to screen mouse genomic DNAs from RF / J , CAST / Ei , MOLF / Ei , Mus musculus musculus , M . m . poschiavinus , and M . spretus . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Expression of oncogenes C myc , C raf and N ras in advanced cancers of the upper respiratory and digestive tracts . ^^^ A correlation between oncogenes expression ( N ras , C myc , C raf ) and response to neoadjuvant chemotherapy has not been established in carcinology of the head and neck yet . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| The hierarchies were as follows : for Raf 1 activation , Ki Ras 4B > Ki Ras 4A > > > N Ras > Ha Ras ; for focus formation , Ha Ras > / = Ki Ras 4A > > > N Ras = Ki Ras 4B ; for anchorage independent growth , Ki Ras 4A > / = N Ras > > > Ki Ras 4B = Ha Ras = no growth ; and for cell migration , Ki Ras 4B > > > Ha Ras > N Ras = Ki Ras 4A = no migration . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Stimulation of cells with epidermal growth factor ( EGF ) or fetal calf serum ( FCS ) resulted in activation of N Ras , but not K Ras , as well as activation of c Raf , MEK 1 , and p 42 MAPK . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| Other high level amplified oncogenes included NRAS , RAF 1 , MYB , EGFR , FGF 4 , EMS 1 , and D17S167 . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| This included oncogene copy number gains of FGFR 1 ( 8p11 ) in three cases , and NRAS ( 1p13 . 2 ) , MYCN ( 2p24 . 1 ) , RAF 1 ( 3p25 ) , CTSB ( 8p22 ) , FES ( 15q26 . 1 ) , and CBFA 2 ( 21q22 . 3 ) in two cases . ^^^ |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01111 and P04049 |
Pubmed |
SVM Score :0.0 |
| NA |
|