| Unusual proteolytic activation of pro hepatocyte growth factor by plasma kallikrein and coagulation factor XIa . ^^^ By screening a panel of serine proteases we identified two new HGF activators , plasma kallikrein and coagulation factor XIa ( FXIa ) . ^^^ In conclusion , the ability of plasma kallikrein and FXIa to activate pro HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also regulate processes that involve the HGF / c Met pathway , such as tissue repair and angiogenesis . . ^^^ |