| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| Both native PCI , modified inhibitor , and complexes of inhibitor with activated protein C or plasma kallikrein could be measured with the assay . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| Complexes of activated protein C ( APC ) with PCI or with alpha 1 antitrypsin ( alpha 1AT ) and of plasma kallikrein with PCI ( KK : PCI ) were measured using sandwich enzyme linked immunosorbent assays . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| In vitro , PCI inhibits activated protein C ( APC ) , thrombin , plasma kallikrein ( KK ) and urokinase ( uPA ) and tissue type plasminogen activator ( tPA ) , and we have shown in vivo inhibition of APC , uPA and KK by PCI . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| The interaction between plasma kallikrein ( KK ) and protein C inhibitor ( PCI ) and the influence of KK on the complex formation between activated protein C ( APC ) and PCI was studied in purified systems as well as in plasma in order to assess the significance of these reactions in the plasma milieu . ^^^ Interaction of plasma kallikrein with protein C inhibitor in purified mixtures and in plasma . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| PCI inhibited activated protein C ( APC ) , two chain urokinase ( 2c uPA ) , two chain tissue plasminogen activator ( 2c tPA ) , thrombin , factor Xa , plasma kallikrein and factor XIa , and this inhibition was accelerated by heparin . ^^^ Plasma kallikrein and factor XIa cleaved PCI of native Mr = 57 , 000 into two products with Mr = 54 , 000 and 52 , 000 whereas the other enzymes converted the PCI to a product with Mr = 54 , 000 . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| PCI purified from outdated plasma was inactive and either in complex with plasma kallikrein or proteolytically degraded . ^^^ Protein C inhibitor from human plasma : characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| Compared with the control group , patients on day 1 had significantly decreased ( p < 0 . 001 ) antigenic protein C ( 69 + / 28 % ) and protein C inhibitor ( PCI ) ( 33 + / 22 % ) whereas a significant increase in the levels of activated protein C ( APC ) complexed with alpha 1 antitrypsin ( alpha 1AT ) ( APC : alpha 1AT , 26 + / 15 ng / mL ) and APC : PCI complex ( 3 . 0 + / 2 . 0 ng / mL ) , and in the level of plasma kallikrein ( KK ) complexes with PCI ( KK : PCI ) ( 31 + / 22 ng / mL ) was observed . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| Inhibition of activated protein C ( APC ) , urokinase plasminogen activator ( uPA ) , tissue plasminogen activator ( tPA ) , thrombin , factor Xa ( Xa ) , factor XIa ( XIa ) and plasma kallikrein ( KK ) by PCI was found to be dependent on the size of the polysaccharide . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| We have now studied the specificity of binding and endocytosis by VLDLR and alpha2MR / LRP among a variety of serine proteinase / serpin complexes , including various combinations of the serine proteinases urokinase type and tissue type plasminogen activators , plasmin , thrombin , human leukocyte elastase , cathepsin G , and plasma kallikrein with the serpins PAI 1 , horse leukocyte elastase inhibitor , protein C inhibitor , C 1 inhibitor , alpha 2 antiplasmin , alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , protease nexin 1 , heparin cofactor 2 , and antithrombin 3 . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| We gave attention that protein C inhibitor ( PCI ) acts as an inhibitor of both plasma kallikrein and thrombin , which are known to act not only as procoagulant proteases but also as chemotactic factors toward phagocytes . ^^^ Our studies have suggested that PCI purified from human urine ( uPCI ) improves the pathophysiology of DIC through the inhibition of activities of plasma kallikrein and thrombin , and the activities of PCI are regulated by N glycans . ^^^ |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03952 and P05154 |
Pubmed |
SVM Score :0.0 |
| NA |
|