| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.80264895 |
| We showed that human TfR 2 alpha interacted with both human and bovine Tf , whereas human TfR 1 interacted only with human Tf . 0.80264895^^^ Furthermore , we demonstrated that mutated TfR 2 alpha ( Y250X ) , which has been reported in patients with hereditary haemochromatosis , also lost its ability to interact with both human and bovine Tf . 0.75708677^^^ |
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| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Taken together , TfR 2 alpha may be a second transferrin receptor that can mediate cellular iron transport . . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Patients with HFE 3 have transferrin receptor 2 ( TFR 2 ) inactivated by a homozygous nonsense mutation ( Y250X ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Complementary and genomic DNA for the murine transferrin receptor 2 ( TfR 2 ) were cloned and mapped to chromosome 5 . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Recently , transferrin receptor 2 ( TfR 2 ) , another receptor for transferrin , was cloned . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin Receptor 2 ( TfR 2 ) is a key molecule involved in the regulation of iron homeostasis . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor 2 ( TfR 2 ) is a membrane glycoprotein that mediates cellular iron uptake from holotransferrin . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Transferrin receptor 2 ( TfR 2 ) is a key molecule involved in the regulation of iron homeostasis . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Two types of mammalian transferrin receptor , TfR 1 and TfR 2 , are now known to exist . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The involved genes are , sinsu strictu , transferrin receptor 2 ( TfR 2 ) , hemojuvelin ( HJV ) , and hepcidin ( HAMP ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Chimeric 2 containing the cytoplasmic domain of the transferrin receptor ( Tfr 2 ) delivers class 2 molecules associated with Tfr 2 to endosomal compartments , but this does not result in efficient antigen presentation . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein ( TfR 2 ) that binds holotransferrin and mediates uptake of transferrin bound iron . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| We recently cloned the human transferrin receptor 2 ( TfR 2 ) gene , which encodes a second receptor for transferrin ( Kawabata , H . , Yang , R . , Hirama , T . , Vuong , P . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Here we report a new locus ( HFE 3 ) on 7q22 and show that a homozygous nonsense mutation in the gene encoding transferrin receptor 2 ( TFR 2 ) is found in people with haemochromatosis that maps to HFE3 . . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| A second receptor for Tf , TfR 2 , was recently identified and found to be functional for iron uptake in transfected cells ( Kawabata , H . , Germain , R . ^^^ To investigate the relationship between TfR , TfR 2 , Tf , and HFE , we performed a series of binding experiments using soluble forms of these proteins . ^^^ The affinity of TfR 2 for iron loaded Tf was determined to be 27 nm , 25 fold lower than the affinity of TfR for Tf . ^^^ These results imply that HFE regulates Tf mediated iron uptake only from the classical TfR and that TfR 2 does not compete for HFE binding in cells expressing both forms of TfR . . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor 2 ( TFR 2 ) mutation Y250X in Alabama Caucasian and African American subjects with and without primary iron overload . ^^^ A mutation of the transferrin receptor 2 gene ( TFR 2 ; exon 6 , nt 750 C > G , replaces TAC with stop signal TAG ; Y250X ) on Ch7q22 was recently identified in two Sicilian families with HFE mutation negative hemochromatosis . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| For each subject we examined intragenic HFE haplotypes and transferrin receptor ( TfR ) gene polymorphisms and searched for the Y250X mutation on the TFR 2 gene . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| In contrast , expression of the transferrin receptor 2 ( TfR 2 ) , which was also cloned in the same vector and stably expressed in the TRVb CHO cells , was not regulated by iron chelation . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| In particular , the identification of the haemochromatosis gene ( HFE ) and more recently the transferrin receptor 2 gene ( TfR 2 ) together with the specific mutations in these genes which result in hepatic iron overload , has enhanced our understanding of the pathophysiology of haemochromatosis . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| These molecules include transferrin ( Tf ) , the oestrogen inducible transferrin receptor like protein , transferrin receptor 2 ( TfR 2 ) , melanotransferrin ( MTf ) , ceruloplasmin , and ferritin . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor 2 ( TfR 2 ) and HFE mutational analysis in non C282Y iron overload : identification of a novel TfR 2 mutation . ^^^ Pathogenic mutations of the transferrin receptor 2 ( TfR 2 ) gene have been identified in 4 Italian pedigrees with the latter syndrome . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Recently a second transferrin receptor ( TFR 2 ) was discovered , and a previously uncharacterized type of hemochromatosis ( HH type 3 ) was identified in humans carrying mutations in the TFR 2 gene . ^^^ The homozygous Tfr 2 ( Y245X ) mutant mice also demonstrated elevated transferrin saturations . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| In the liver , CP ( / ) mice showed no increase of gene expression for DMT 1 and transferrin receptors ( TFR and TFR 2 ) , indicating that none of the known pathways of iron uptake is activated in hepatocytes of CP ( / ) mice . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Human transferrin receptor 2 ( TFR 2 ) is a protein highly homologous to TFR 1 / CD71 and is endowed with the ability to bind transferrin ( TF ) with low affinity . ^^^ Exposure of human TFR 2 ( + ) cells to TF bound iron is followed by a significant up regulation and relocalization of membrane TFR 2 . ^^^ The tissue distribution pattern , the behavior following exposure to iron loaded TF , and the features of the disease resulting from TFR 2 inactivation support the hypothesis that TFR 2 contributes to body iron sensing . . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| TfR 2 is capable of Tf mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis unrelated to the hereditary hemochromatosis protein , HFE . ^^^ Recently , a second transferrin receptor , transferrin receptor 2 ( TfR 2 ) , has been identified and shown to play a critical role in iron metabolism . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Progress in our understanding of how HFE regulates the absorption of dietary iron has been slow , but much can be learnt from the study of the rare instances of haemochromatosis that involve mutations in newly identified iron metabolism genes , such as TFR 2 a transferrin receptor isoform and ferroportin1 / Ireg1 / mtp1 an intestinal iron transporter . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Recently , a close homologue of human transferrin receptor 1 was cloned and called transferrin receptor 2 ( TfR 2 ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The gene responsible is Transferrin Receptor 2 ( TFR 2 ) , which maps to chromosome 7q22 . ^^^ The TFR 2 gene presents a significative homology to transferrin receptor ( TFRC ) gene , encodes for a transmembrane protein with a large extracellular domain , is able to bind transferrin , even if with lower affinity than TFRC . ^^^ Using anti TFR 2 monoclonal antibodies we have confirmed expression of the protein in the liver but also in duodenal epithelial cells , and studied the protein functional behaviour in cell lines , in response to iron addition , iron deprivation and olo transferrin exposure . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| HFE , the protein defective in hereditary hemochromatosis , and transferrin receptor 2 ( TfR 2 ) are two novel protein candidates that could be involved in mechanisms of iron transport across the platelet plasma membrane . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The transferrin receptor 2 ( TFR 2 ) and hereditary hemochromatosis ( HFE ) genes were examined to see if inheritance of these gene defects may be a possible cause of iron overload in 45 HbH patients . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| DESIGN AND METHODS : Taking advantage of the collection of 178 DNA samples selected for increased transferrin saturation ( > 50 % in males and > 45 % in females ) from a previous large scale screening of Italian blood donors , we simultaneously assessed the presence of 14 hemochromatosis associated molecular defects ( 11 of HFE and 3 of TFR 2 ) by a reverse hybridization based strip assay . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Considering the high homology of MTf to Tf , it is possible to suggest that sMTf could bind to the high affinity transferrin receptor 1 ( TfR 1 ) or lower affinity TfR 2 . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Co localization of the mammalian hemochromatosis gene product ( HFE ) and a newly identified transferrin receptor ( TfR 2 ) in intestinal tissue and cells . ^^^ Mutations in the HFE gene and a newly identified second transferrin receptor gene , TfR 2 , cause hemochromatosis . ^^^ HFE is expressed in small intestinal crypt cells where transferrin iron entry may determine subsequent iron absorption by mature enterocytes , but the physiological function of TfR 2 is unknown . ^^^ In human Caco 2 cells , HFE and TfR 2 co localized to a distinct CD 63 negative vesicular compartment showing marked signal enhancement on exposure to iron saturated transferrin ligand , indicating that HFE preferentially interacts with TfR 2 in a specialized early endosomal transport pathway for transferrin iron . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| We examined transferrin receptor ( TfR ) 1 and TfR 2 mRNA expression in 50 acute myeloid leukemia ( AML ) patients by RT PCR , with primers specific for exons 15 17 ( TfR 1 ) , 3 5 ( TfR 2 alpha ) and 4 5 ( TfR 2 beta ) of the corresponding gene . ^^^ |
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| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The effects of cellular proliferation on the uptake of transferrin bound iron ( Tf Fe ) and expression of transferrin receptor 1 ( TfR 1 ) and transferrin receptor 2 ( TfR 2 ) were investigated using a human hepatoma ( HuH 7 ) cell line stably transfected with TfR 1 antisense RNA expression vector to suppress TfR 1 expression . ^^^ An increase in Tf Fe uptake by NTfR 1 mediated pathway was correlated with an increase in TfR 2 alpha protein expression but not TfR 2 alpha mRNA . ^^^ In conclusion , TfR 2 alpha protein is likely to have a role in the mediation of Tf Fe uptake by the NTfR 1 process by HuH 7 hepatoma cell in proliferating and stationary stages of growth . . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Levels of type 1 hereditary hemochromatosis gene ( HFE ) , transferrin , hepcidin , transferrin receptors 1 and 2 ( TfR 1 , TfR 2 ) , ferroportin 1 ( FPN 1 ) , divalent metal transporter 1 ( DMT 1 ) , natural resistance associated macrophage protein 1 ( Nramp 1 ) , ceruloplasmin , hephaestin , and glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , were measured by quantitative reverse transriptase polyerase chain reaction ( qRT PCR ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The disorder is mainly attributable to the C282Y and H63D mutations in the HFE gene , but additional mutations in the HFE , transferrin receptor 2 ( TfR 2 ) , and hepcidin genes have been reported . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Suppression of TfR 1 does not lead to down regulation of TfR 2 , a recently described second transferrin receptor of as yet uncertain function . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor 2 ( TfR 2 ) , another receptor for transferrin ( Tf ) , has recently been cloned . ^^^ Transferrin receptor 2 ( TfR 2 ) , another receptor for transferrin ( Tf ) , has recently been cloned . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The transferrin receptor ( TFR 2 ) linked form is inherited in an autosomal recessive pattern and is considered to be an adult onset syndrome . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The physiological role of transferrin ( Tf ) receptor 2 ( TfR 2 ) , a homolog of the well characterized TfR 1 , is unclear . ^^^ We report that HepG 2 cells , which endogenously express TfR 2 , display a biphasic pattern of Tf uptake when presented with ligand concentrations up to 2 muM . ^^^ Exogenous expression of TfR 2 but not TfR 1 induces a similar biphasic pattern of Tf uptake in HeLa cells , supporting a role for TfR 2 in this process . ^^^ Immunoelectron microscopy reveals that while Tf , TfR 1 , and TfR 2 are localized in the plasma membrane and tubulovesicular endosomes , TfR 2 expression is associated with the additional appearance of Tf in multivesicular bodies . ^^^ These combined results imply that unlike TfR 1 , which recycles apo Tf back to the cell surface after the release of iron , TfR 2 promotes the intracellular deposition of ligand . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| ApoTf or high iron treatment with non Tf bound iron failed to elicit similar effects , suggesting that TfR 2 regulation reflects interactions of the iron bound ligand . ^^^ In contrast , TfR 2 levels were reduced in hypotransferrinemic mice despite liver iron overload , supporting the idea that regulation of the receptor is dependent on Tf . ^^^ This idea is confirmed by up regulation of TfR 2 in beta thalassemic mice , which , like hypotransferrinemic mice , are anemic and incur iron loading , but have functional Tf . ^^^ Based on these combined results , we hypothesize that TfR 2 acts as a sensor of iron status such that receptor levels reflect Tf saturation . . ^^^ Transferrin receptor 2 ( TfR 2 ) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR 2 gene suffer from hemochromatosis . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor 2 ( TfR 2 ) is a type 2 transmembrane protein expressed in hepatocytes that binds iron bound transferrin ( Tf ) . ^^^ Western blot analysis shows that TfR 2 increases in a time and dose dependent manner after diferric Tf is added to the culture medium . ^^^ In cells exposed to diferric Tf , the amount of TfR 2 returns to control levels within 8 hours after the removal of diferric Tf from the medium . ^^^ However , TfR 2 does not increase when non Tf bound iron ( FeNTA ) or apo Tf is added to the medium . ^^^ Real time quantitative reverse transcription polymerase chain reaction ( qRT PCR ) analysis shows that TfR 2 mRNA levels do not change in cells exposed to diferric Tf . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The relationship between the hemochromatosis due to transferrin receptor 2 ( TFR 2 ) mutations and hepcidin was unknown . ^^^ We measured urinary hepcidin levels in 10 patients homozygous for TFR 2 mutations , all with increased transferrin saturation . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Genetic hemochromatosis now corresponds to six diseases , namely classical hemochromatosis HFE 1 ; juvenile hemochromatosis HFE 2 due to mutations in an unidentified gene on chromosome 1 ; hemochromatosis HFE 3 due to mutations in the transferrin receptor 2 ( TfR 2 ) ; hemochromatosis HFE 4 caused by a mutation in the H subunit of ferritin ; and hemochromatosis HFE 6 whose gene is hepcidine ( HAMP ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Overexpression of mouse Tfr 1 , mouse Tfr 2 , and zebrafish tfr1b partially rescued hypochromia in cia embryos , establishing that each of these transferrin receptors are capable of supporting iron uptake for hemoglobin production in vivo . ^^^ |
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| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Other hepatic proteins essential for normal iron homeostasis , including HFE , transferrin receptor 2 ( TfR 2 ) , and hemojuvelin , function at least in part , by modulating the expression of hepcidin . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| In a previous report , we showed that 3 patients from one family had an AVAQ 594 597 deletion of the transferrin receptor ( TfR 2 ) gene . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| In the present study , hepatic messenger RNA ( mRNA ) expression of transferrin receptor ( TfR ) 1 , TfR 2 , and ferroportin ( FP ) 1 was measured in patients with chronic hepatitis ( CH ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer , we analyzed 19 sequence variations at HFE , TFR 1 , TFR 2 , and FPN 1 and compared genotype frequencies between cases and controls in a German population . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to evaluate whether the hepatic expression of HAMP in relation to iron stores requires HFE or might involve other important iron related genes including HJV ( encoding hemojuvelin ) and TFR 2 ( encoding transferrin receptor 2 ) . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The genetics of these less common forms was intensively studied between 2000 and 2004 , leading to the recognition of haemojuvelin ( HJV ) , hepcidin ( HAMP ) , transferrin receptor 2 ( TFR 2 ) and ferroportin related haemochromatosis , and opening the way for novel hypotheses such as those related to digenic modes of inheritance or the involvement of modifier genes . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The genes coding for HFE , transferrin receptor 2 ( TFR 2 ) , ferroportin ( SLC40A1 or FPN 1 ) , hepcidin ( HEPC ) and hemojuvelin ( HJV or RGMC ) are responsible for different types of genetic iron overload . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| The activity of ferroportin 1 is controlled by the liver derived peptide hepcidin , and the expression of hepcidin in turn is influenced by plasma transferrin saturation via a pathway that involves HFE , TfR 2 , and hemojuvelin . ^^^ |
|
| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Rare defects , including mutations in the transferrin receptor 2 ( TFR 2 ) gene , have also been identified in pedigrees affected with `` non HFE hemochromatosis . ' ' Homozygous mutations in the newly identified genes encoding hemojuvelin ( HFE 2 ) and hepcidin ( HAMP ) cause juvenile hemochromatosis . ^^^ |
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| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| We report three mutations of transferrin receptor 2 ( TFR 2 ) R396X ( exon 9 ; nt 1186C > T ) , R455Q ( exon 10 ; nt 1364G > A ) and G792R ( exon 18 ; nt 2374G > A ) in a man of Scottish descent with hemochromatosis and severe iron overload . ^^^ |
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| Interacting proteins: Q9UP52 and P02787 |
Pubmed |
SVM Score :0.0 |
| Bone morphogenetic proteins 2 , 4 , and 9 stimulate murine hepcidin 1 expression independently of Hfe , transferrin receptor 2 ( Tfr 2 ) , and IL 6 . ^^^ We investigate the role of Hfe , Tfr 2 ( transferrin receptor 2 ) , and IL 6 in BMP 2 , BMP 4 , and BMP 9 stimulated up regulation of murine hepcidin , because these molecules , like Hjv , are known to be involved in hepcidin signaling . ^^^ |
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