Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.64110006
Addition of transferrin ( Tf ) to HFE LAMP expressing cells competes with HFE for binding to the TfR , thereby increasing the half life of TfR and confirming that the HFE LAMP TfR complex reaches the cell surface prior to entering the endosomal vesicles and trafficking to the lysosome . 0.64110006^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.67419749
In this issue of Cell , Cheng et al . , describe the molecular structure of the human TfR 1 Tf complex , This atomic model shows that Tf binds laterally to the TfR 1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane . . 0.67419749^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :1.0764014
We showed that human TfR 2 alpha interacted with both human and bovine Tf , whereas human TfR 1 interacted only with human Tf . 1.0764014^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.80509322
Using a cell line lacking endogenous transferrin receptors ( TRVb cells ) transfected with different forms of HFE and TfR 1 , we demonstrate that even at low concentrations Tf competes effectively with HFE for binding to TfR 1 on living cells . 0.80509322^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.65913726
The TFR 2 gene presents a significative homology to transferrin receptor ( TFRC ) gene , encodes for a transmembrane protein with a large extracellular domain , is able to bind transferrin , even if with lower affinity than TFRC . 0.65913726^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Basophils apparently lack CD 22 antigen , gangliosides detected by CDw 65 mAbs ( except CDw65L ) and CD 71 antigen ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The blocking of CD 71 antigen ( transferrin receptor ) on K 562 blasts inhibited binding of cytotoxic lymphocytes , which was mostly due to the blocking of binding of CD56+ subpopulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
CD26 / DPP 4 activity strongly paralleled the CD 71 antigen ( transferrin receptor , T cell activation / proliferation antigen ) expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The antibodies used were Ki 67 , cytokeratin 8 . 12 , and antibodies against the receptors for epidermal growth factor ( EGFr ) and transferrin ( TFr ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We evaluated endogenous EPO production through serum EPO levels and erythroid marrow activity by means of serum transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Human placenta microvillous membrane ( PMM ) was prepared by differential centrifugation and by sucrose gradient centrifugation , and the transferrin receptor ( TfR ) was studied using the receptor radioassay with 125I transferrin as a radioligand . ^^^ The result showed that there was no significant differences ( P > 0 . 1 ) in specific binding rates of 125I transferrin to its receptor between the two membrane preparations , indicating that both of them could be used for TfR analysis , but the method of differential centrifugation was more simple and less time consuming . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By means of immunohistochemical technique ABC , using monoclonal anti transferrin receptor ( TFR ) antibodies WuT 9 and OKT 9 , TFR expression in 30 cases of hepatocellular carcinoma ( HCC ) and in 6 cases of organs and tissues of normal human bodies was studied . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The changes of T cell subsets and expression of transferrin receptor ( TFR ) and interleukin 2 receptor ( IL 2 R ) of peripheral blood lymphocyte from patients with chronic active hepatitis ( ACH ) and chronic serious hepatitis ( CSH ) were studied . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously shown that adriamycin ( 40 nM ) and aclacinomycin ( 15 nM ) can induce , in vitro , an increase of glycophorin A ( GPA ) on K 562 cells , a modulation of transferrin receptor ( TfR ) and CD 15 antigen expression and a significant resistance of cells to NK mediated lysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously demonstrated that the human transferrin receptor ( TfR ) of approximately 90 kDa contains Ser / Thr linked ( O linked ) oligosaccharides . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Post transcriptional regulation of genes important in iron metabolism , ferritin and the transferrin receptor ( TfR ) , is achieved through regulated binding of a cytosolic protein , the iron responsive element binding protein ( IRE BP ) , to RNA stem loop motifs known as iron responsive elements ( IREs ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we have studied the trafficking of major histocompatibility complex ( MHC ) Class 1 molecules and transferrin receptor ( Tfr ) related to their phosphorylation status in the human lymphoblastoid cell line JY . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By immunocytochemistry , the bulk of Tf and TfR was localized at the plasma membrane and in tubuloreticular early endosomes . ^^^ Decreasing amounts of both Tf and TfR were detected in two distal compartments , spherical endosome vesicles resembling multivesicular bodies and the prelysosomal compartment ( PLC ) enriched in cation independent mannose 6 phosphate receptor . ^^^ As shown by fluorescent ( FITC Tf ) labelling of living cells , the movement of Tf / TfR complex into these late structures was accompanied by a significant drop in pH from about 6 , the value displayed by early endosomes , to values below pH 5 . 0 . ^^^ Since no detectable 125I Tf degradation was observed during a 4 h period we believe that the Tf / TfR detected in these late endocytic structures avoids degradation and recycles back to the cell surface . ^^^ These cells express high levels of transferrin receptors ( TfR ) when induced to differentiate at 42 degrees C . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , iron uptake is largely regulated via multiple IREs in the 3 ' UTR of transferrin receptor ( TfR ) mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cell surface expression of transferrin receptor ( TfR ) and IL 2 receptor alpha ( p 55 ) were inhibited by 20 80 % in the Con A / rIL 2 system and 20 45 % in the PHA system in the presence of TGF beta . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Erythropoietin ( Epo ) production was evaluated by serum levels and erythropoiesis was quantitated by serum transferrin receptor ( TfR ) levels , both assessed relative to the degree of anaemia . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Fetal cells were separated by fluorescence activated cell sorting using monoclonal antibody to the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Infiltrating mononuclear cell ( MNC ) subsets and transferrin receptor ( TfR ) expression at the localized lesions were studied in 28 cases of gastric carcinoma and 36 cases of colorectal carcinoma by immunohistochemical technique by using a panel of monoclonal antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have constructed a murine hybrid hybridoma that secretes a bispecific monoclonal antibody ( mAb ) by fusing a hybridoma secreting an anti ansamitocins mAb with a hybridoma secreting an anti human transferrin receptor ( TfR ) mAb that binds to human A 431 epidermoid carcinoma cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To gain insights at the molecular level into the expression of iron regulated genes [ transferrin ( Tf ) , transferrin receptor ( TfR ) , and ferritin H and L subunits ] in human intestinal areas relevant to iron absorption , the steady state levels of specific messenger RNAs ( mRNAs ) were analyzed in gastric and duodenal samples obtained from 6 normal subjects , or 10 patients with anemia , 14 patients with untreated iron overload , and 8 patients with various gastrointestinal disorders . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Almost all the LBCs express Leu 19 , TfR ( transferrin receptor ) , LFA 1 and CD 38 ( OKT 10 ) antigens , which are expressed on activated T cells , NK cells and some other lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mechanism by which a clone of HL 60 human promyelocytic leukemia cells designated Tf Gel 1 expresses reduced levels of the transferrin receptor ( TfR ) was investigated . ^^^ The amount of cell surface , as well as of solubilized , TfR and the cycling pools of TfR in Tf Gel 1 cells , as measured by the binding of [ 125I ] Tf , were all decreased to 20 30 % of the levels present in parental cells . ^^^ Southern hybridization of cellular DNA with TfR cDNA did not reveal differences between parental and Tf Gel 1 cells in the level and arrangement of the TfR gene . ^^^ Basal and inducible ( repressible ) levels of TfR mRNA from Tf Gel 1 cells , as measured by northern hybridization of cellular RNA with TfR cDNA , were comparable to those of parental cells . ^^^ The decrease in the surface membrane concentration of the TfR in Tf Gel 1 cells was specific for this glycoprotein , since the levels of other cell surface antigens , such as CD 13 , CD 15 and CD 45 , were normal in Tf Gel 1 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effects of tautomycin , a protein phosphatase inhibitor , on recycling of cell surface molecules were studied with transferrin receptor ( TFR ) of human myeloid leukemia K 562 cells and with CD 4 of murine thymocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Results show that both CD4+ and CD8+ T clones can process and present HBenvAg to class 2 restricted cytotoxic T lymphocytes and that the CD 71 transferrin receptor ( TfR ) is involved in efficient HBenvAg uptake by T cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Sephadex injection did not differ in CP treated vs control chickens with respect to cell number , cell type , superoxide anion production , or cell surface expression of Ia and transferrin receptor ( TfR ) antigens . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Removal of complement receptors CR 1 and CR 3 , the Fc receptor ( FcR ) , and the transferrin receptor ( TfR ) resulted in significantly lower levels of MAC uptake in serum free medium by both PBMs and AMs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is found in the vigorous proliferating cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effects of brefeldin A ( BFA ) on transferrin ( Tf ) transcellular transport , Tf receptor ( TfR ) distribution , and TfR mediated endocytosis in filter grown Madin Darby canine kidney ( MDCK ) cells were studied . ^^^ In addition , BFA treatment to MDCK cells : ( a ) increased 125I Tf specific binding to the apical membrane and decreased 125I Tf specific binding to the basal membrane ; ( b ) decreased TfR recycling at the basolateral membrane ; ( c ) altered the apical / basolateral distribution of TfRs in favor of the apical side ; and ( d ) markedly increased 59Fe extraction , but not transcytosis , from apically endocytosed 59Fe loaded Tf . ^^^ These effects are consistent with a model in which BFA alters the traffic pattern of internalized Tf by decreasing basolateral TfR recycling , while diverting the nonrecycled fraction to the apical side of the cell . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Previously we demonstrated two separate Fe uptake mechanisms from Tf , viz . a specific process mediated by the transferrin receptor ( TfR ) and a nonspecific process ( Richardson , D . ^^^ Desferrioxamine also stimulated the nonspecific process of Fe uptake , resulting in a further increase in accumulation of Fe over Tf after saturation of the specific TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We recently reported that the human transferrin receptor ( TfR ) contains O linked GalNAc residues [ 1 ] . ^^^ To investigate whether this modification is shared by transferrin receptors in other mammals , we investigated the glycosylation of TfR in hamster cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The uptake of gallium 67 ( 67Ga ) into cells is postulated to be through transferrin receptors ( TFR ) of 67Ga combined with transferrin . ^^^ These findings suggest that 67Ga citrate initially combines with transferrin in the blood and then the complex is incorporated into cells through TFR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptors ( TfR ) were measured in benign and malignant prostatic cells by performing Scatchard analysis following the administration of 125I transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using anti proteoglycan ( PG ) antibodies and immunoelectronmicroscopy , two heparan sulphate proteoglycans ( transferrin receptor ( TfR ) and fibroblast membrane type ) and one chondroitin sulphate proteoglycan ( articular cartilage type ) molecule were co localized as random clusters on the surface of these lymphoma cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined elicited chicken peritoneal exudate cells ( PECs ) with respect to superoxide anion production , arachidonic acid metabolism and cell surface Ia and transferrin receptor ( TfR ) expression from 4 to 96 h after i . p . stimulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Northern blot analysis showed a 2 to 3 fold increase of TfR mRNA of NKM 1 cells cultured in medium containing Tf and G CSF , whereas the mRNA declined without G CSF . ^^^ Granulocyte colony stimulating factor ( G CSF ) enhanced surface transferrin receptor ( TfR ) expression in two human myeloid leukemia cell lines , NKM 1 and NOMO 1 , which possess G CSF receptors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously shown that transferrin receptor ( TfR ) recycles from the cell surface through the Golgi complex in K 562 human leukemia cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We evaluated erythropoiesis by measuring serum transferrin receptor ( TfR ) levels in 406 women during normal pregnancy ( N = 317 ) , at delivery ( N = 63 ) , or in the early postpartum ( N = 27 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
TfR expression increased in the course of induction , as judged by increased TfR mRNA synthesis , increased cytoplasmic TfR mRNA level , and by the increased number of cellular 125I Tf binding sites . ^^^ The coordination of transferrin receptor ( TfR ) expression and heme synthesis was investigated in mouse erythroleukemia ( MEL ) cells of line 707 treated with heme synthesis inhibitors or in a variant line Fw genetically deficient in heme synthesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Quantitative ultrastructural and biochemical methods have allowed us to obtain a coherent set of data on the internalization efficiency of the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To compare the time course of in vitro expression of various proliferation associated markers including Ki 67 antigen , transferrin receptors ( TfR ) , and DNA polymerase alpha , six human tumour cell lines of different histological origin were studied under defined conditions . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Pancreatic tissues from these iron overloaded rats and untreated controls were examined for insulin ( for B cells ) , glucagon ( for A cells ) , transferrin receptor ( TfR ) , transferrin ( Tf ) and ferritin ( Ft ) using immunohistochemical methods , and for iron by histochemical Berlin blue staining . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A series of phosphodiester and phosphorothioate antisense oligodeoxynucleotides were synthesized against the human transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study we have investigated the effect of modulation of the T cell antigen receptor complex ( TCR ) and the transferrin receptor ( TFR ) on the distribution of cholera toxin ( CTx ) and pertussis toxin ( PTx ) sensitive GTP binding proteins in human T lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The present investigations used two color flow cytometry to examine B lymphocytes from the spleens and lymph nodes of PC mice and found decreased surface membrane expression of surface IgM ( sIgM ) , transferrin receptors ( TfR ) and IgE FcR ( CD 23 ) , increased expression of class 2 MHC , but normal expression of B 220 , Mel 14 , Fc gamma RII , and Fc mu R . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Experiments to determine the frequencies of B cells with transferrin receptors ( TfR ) and low affinity receptors for IgE ( Fc epsilon RII / CD23 ) showed reductions in the expression of these two glycoproteins among stimulated B cells from elderly with the persistent decreases in proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The distribution of transferrin receptor ( TfR ) in normal human brain tissue obtained at autopsy and in brain tumor biopsy specimens from 27 patients was determined by immunohistochemistry using two specific murine monoclonal antibodies against human TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The intracellular iron level exerts a negative feedback on transferrin receptor ( TfR ) expression in cells requiring iron for their proliferation , in contrast to the positive feedback observed in monocytes macrophages . ^^^ It has been suggested recently that modulation of TfR and ferritin synthesis by iron is mediated through a cytoplasmic protein ( s ) ( iron regulatory element binding protein ( s ) ( IRE BP ) ) , which interacts with ferritin and TfR mRNA at the level of hairpin structures ( IRE ) , thus leading to inhibition of transferrin mRNA degradation and repression of ferritin mRNA translation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) immunoreactivity in the developing chick retina was examined . ^^^ TfR ' s developmental distribution in the retina may reflect the developmental and physiological role of transferrin . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This atom is tightly bound to serum transferrin ( Tf ) and is taken up by erythroblasts and reticulocytes through transferrin receptor ( TfR ) . ^^^ Both Tf and TfR are reutilizable and have roles for the efficient intracellular accumulation of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Turnover of the full length human transferrin receptor ( TfR ) mRNA is regulated by iron , and this regulation is mediated by the transcript ' s 3 ' untranslated region . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of succinylacetone ( SA ) , a highly specific inhibitor of ALA dehydratase and heme synthesis , on hemoglobin ( Hb ) production , transferrin receptor ( TfR ) , and ferritin expression was analyzed in differentiating Friend leukemia cells ( FLC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this paper , we provide evidence for an incompletely glycosylated transferrin receptor ( TfR ) which is not transported to the plasma membrane in the sheep reticulocyte . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Despite the low numbers of TfR expressed by post confluent cells , filter grown BMEC monolayers were used to measure transcytosis of Tf . ^^^ These results showed that cultured BMECs cycle Tf TfR complexes slowly and vectorially and suggested that the large intracellular receptor pool may facilitate steady state accumulation and regulate transcellular transport of iron . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Only two antibodies , MEM 75 and 120 2A3 , both directed against the transferrin receptor ( TfR ) were predicted to form immunotoxins that would inhibit protein synthesis by the cells by 50 % at a concentration ( IC 50 ) of 10 ( 8 ) M or less . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Evidence for major rearrangements or deletions at the HLA class 1 region and at three loci directly involved in iron metabolism ( H and L apoferritin and the transferrin receptor [ TfR ] ) was sought . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
T cell antigen expression following PHA stimulation was assessed for helper ( CD 4 ) and suppressor ( CD 8 ) subpopulations : the early T cell activation antigens interleukin 2 receptor ( IL2R ) and transferrin receptor ( TFR ) , and the late antigen ( HLA DR ) using flow cytometry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present communication we show that the reduction of Tf concentration in culture media results in a decreased proliferation , whereas lymphokine production and the expression of activation markers ( IL 2 receptor ; transferrin receptor , ( TfR ) ; HLA class 2 ) remain unchanged . ^^^ Addition of a monoclonal TfR antibody , J 64 , also caused a marked inhibition of proliferation of PBMC in regular serum containing medium as well as in Tf free synthetic medium ; this effect could not be overcome by any of the tested iron chelates . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An immunohistochemical staining method was used to study transferrin receptors ( TFR ) in bladder tissue from 10 patients with benign conditions and 33 with bladder cancer . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using clotting assay and radioimmunoassay ( RIA ) , tissue factor activity ( TFA ) and TF related antigen ( TFR : AG ) were determined in an extracellular culture medium of HL 60 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Epidermal growth factor receptors ( EGFR ) and transferrin receptors ( TFR ) are known to be involved in cell proliferation and to be expressed in normal human epidermis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The two receptors , interleukin 2 receptor ( IL 2 ) , transferrin receptor ( TfR ) , were identified using monoclonal antibodies anti IL 2 and OKT 9 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Exogenous IL 2 did not increase either IFN gamma production or transferrin receptor ( TfR ) expression in the presence of calcitriol despite increases in cell entry into late G 1 and proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we have examined the effect of HSF on the generation of T cell derived lymphokines that regulate B cell growth and differentiation as well as the expression of other proteins involved in the control of T cell growth i . e . , the p 55 chain of the IL 2R and the transferrin receptor ( TFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Excess iron results in an increase in the translation of ferritin mRNA and a decrease in the stability of transferrin receptor ( TfR ) mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of the monoclonal antibodies ( mAb ) , FG 1 / 5 , FG 1 / 6 and FG 2 / 12 , specific for different epitopes of the transferrin receptor ( TfR ) on T cell activation was studied . mAb FG 1 / 6 but not FG 2 / 12 or FG 1 / 5 was able to induce T cell proliferation in presence of submitogenic doses of phorbol esters . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) expression in a population of murine macrophages was investigated during the colony stimulating factor 1 ( CSF 1 ) induced proliferation and quiescence . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We studied the intracellular traffic and subcellular distribution of MHC class 1 and class 2 antigens in comparison with a recycling surface glycoprotein , the transferrin receptor ( Tfr ) , in the human lymphoblastoid cell line JY . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Surprisingly , however , whole anti Ig was unable to inhibit induction of transferrin receptor ( TfR ) expression by LPS or F ( ab ' ) 2 anti Ig . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The interactions between transferrin ( Tf ) and transferrin receptor ( Tfr ) as they occur during biosynthesis were studied in the human hepatoma cell line HepG 2 , which synthesizes both . ^^^ The Tfr monomer is not able to bind Tf , but Tf binding is observed as soon as the covalent Tfr dimer is formed and can take place in the ER . ^^^ The Tf Tfr complex is transported through the Golgi reticulum and trans Golgi reticulum ( TGR ) and is ultimately delivered to an acidic compartment , where Tf releases its Fe3+ . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We used monoclonal antibody against the transferrin receptor ( TfR ) to identify nucleated erythrocytes in the peripheral blood of pregnant women . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The following Becton Dickinson MAbs have been used : anti Leu 4 ( CD 3 ) , anti IL 2 receptors ( CD 25 ) , anti Transferrin receptor ( TFR ) and anti Leu 11b ( CD 16 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The synthesis of both transferrin receptor ( TfR ) and ferritin is regulated post transcriptionally by iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using immunohistochemical and flow cytometric techniques , we have studied the significance of cellular expression of the Ki 67 antigen , epidermal growth factor receptor ( EGFR ) , the transferrin receptor ( TFR ) and DNA ploidy status in a prospective analysis of patients with SCCs of the head and neck region . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Peritoneal macrophages from patients on continuous ambulatory peritoneal dialysis ( CAPD ) were investigated with respect to their ability to release H2O2 and express HLA DR and transferrin receptors ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Raising the levels of intracellular iron by treatment of Friend 707 cells with either hemin , Fe pyridoxal isonicotinoyl hydrazone ( PIH ) or diferric transferrin ( Tf ) resulted in decreased levels of the labeled TfR mRNA . ^^^ The effect of changes of iron availability in the culture medium on the expression of TfR ( transferrin receptor ) and glutathione peroxidase ( GSHPx ) genes was investigated in uninduced or induced murine erythroleukemia ( Friend ) cells of lines 707 and Fw labeled with ( 3H ) uridine for 3 h . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These exosomes carry the transferrin receptor ( TFR ) as well as other plasma membrane and lysosomal activities which the cells are known to lose during maturation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We previously described a transferrin receptor ( TfR ) mechanism that controls iron entry into rat mammary tissue . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined the relationship of cellular oncogene c myc and transferrin receptor ( TfR ) gene expression to cell proliferation and cell cycle progression during myeloid differentiation in the HL 60 myeloid leukemia cell line . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated the effects of the iron chelator desferrioxamine on the expression of transferrin receptors ( TfR ) by CCRF CEM human T cell leukaemia and B 16 mouse melanoma cells growing in tissue culture . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Three color FACS analysis showed that the expression of transferrin receptor ( TFR ) was at its maximum in Ba+ / IgD cells , and the intensity of this expression was proportional to that of Ba expression in Ba+ / IgD+ cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have studied the effect of this compound on the expression of ODC , transferrin receptor ( TFR ) , and beta globin during normal cellular proliferation and dimethylsulfoxide induced terminal differentiation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TFR ) which is present on dividing cells , many tumours and erythroid precursors is readily identified using specific monoclonal antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The biosynthetic rates for both the transferrin receptor ( TfR ) and ferritin are regulated by iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Purified , small resting mouse B cells appear to express low levels of transferrin receptor ( TfR ) as detected by flow cytometry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In attempting to identify antigens that are differentially expressed on tumor cells following transformation from follicular small cleaved cell lymphoma ( FSC ) to immunoblastic lymphoma ( IL ) , we identified a unique epitope of the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The level of mRNA encoding the transferrin receptor ( TfR ) is regulated by iron , and this regulation is mediated by a portion of the 3 ' untranslated region ( UTR ) of the TfR transcript . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two immunotoxins were constructed by coupling LysPE 40 to an antibody to the human transferrin receptor ( TFR ) or to an antibody to the human interleukin 2 receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using an indirect immunoperoxidase technique on frozen sections with the monoclonal antibody 96 . 5 , we investigated the in situ distribution of melanotransferrin , a transferrin ( Tf ) and transferrin receptor ( TfR ) related glycoprotein , in human liver . ^^^ The present results show that in the liver melanotransferrin has a localization different from Tf and the TfR . ^^^ In addition , there does not appear to be a coordinate regulation secondary to iron storage , between melanotransferrin , Tf and the TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We compared the intracellular pathways of the transferrin receptor ( TfR ) with those of the asialoglycoprotein receptor ( ASGPR ) and the cation independent mannose 6 phosphate receptor ( MPR ) / insulin like growth factor 2 receptor during endocytosis in Hep G 2 cells . ^^^ Cells were allowed to endocytose a conjugate of horseradish peroxidase and transferrin ( Tf / HRP ) via the TfR system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition , receptor mediated transport of heme into Hepa cells significantly decreases the steady state level of transferrin receptor ( TfR ) mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Quantitative Western blotting of the endogenous transferrin receptor ( tfR ) demonstrated the presence , on average , of roughly one receptor per vesicle . ^^^ TfR appeared undersaturated with transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Surface marker analyses of Tac antigen and transferrin receptor ( TfR ) showed that the presence of IFN alpha throughout the culture period significantly suppressed the typical increase in IL 2 induced Tac and TfR positive cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The distribution of transferrin receptor ( TfR ) positive cells and their staining intensity were examined in the liver , duodenum , pancreas , spleen , kidney and brain of iron deficient , iron overloaded and normal Wistar rats to elucidate the regulatory effects of iron on TfR expression in vivo . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On the other hand , expression of transferrin receptors ( TfR ) , which first occurs between 20 and 24 h after lymphocyte activation , was markedly suppressed by T . cruzi . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Analysis of the changes of surface marker expression of human PBMC during preincubation with CySF L 1 revealed an efficient stimulation of CD 8 and TfR ( transferrin receptor ) expression , partly in conjunction with diminished expression of CD 4 ( T 4 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Proportions of T lymphocyte subsets ( OKT 3 , OKT 4 , OKT 8 ) and expression of interleukin 2 ( IL 2 ) , transferrin ( TFR ) receptors and HLA DR antigens were studied in the peripheral blood of 21 healthy HBsAg carriers , 10 patients with chronic active hepatitis B ( CAH ) , 10 patients with alcoholic liver cirrhosis ( ALC ) and 10 subjects with negative markers of previous hepatitis B virus ( HBV ) infection . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this model , the sole source of Tf which is donated to muscle cells should be the nerve , and Tf should not be provided for muscle fiber at sites other than the synaptic region ; otherwise , denervation atrophy would not occur , since Tf provided from TfR located at another site would cancel the effect of denervation . ^^^ This implies that an adequate amount of Tf is transferred from serum to tissue fluid ; in this case TfR may be distributed over the entire surface of the cells . ^^^ It is entirely plausible that muscle fibers require an amount of Tf , and that this is provided by TfR scattered on the cell surface . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although both groups had an increase in interleukin 2 receptor ( IL2R ) , transferrin receptor ( TfR ) , and MHC class 2 Ag ( HLA DR ) positive cells after PHA stimulation , the mean percentage of TfR+ cells was significantly greater in the young than in the elderly ( p less than 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of transferrin receptors ( TFR ) is required for lymphocyte proliferation . ^^^ To elucidate effects of phorbols on lymphocyte growth and differentiation , we examined TFR expression by measuring 125I transferrin binding , levels of TFR mRNA by Northern analysis and dot blot hybridization , and rates of TFR gene transcription by nuclear run on experiments in CCRF CEM lymphoblastoid T cells treated with PMA or phorbol dibutyrate . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , during the first 48 h , neither the expression of the 55 kd chain of the IL 2 receptor ( IL 2R ) nor the expression of the transferrin receptor ( TfR ) was affected by TGF beta . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Activated T cells were identified by double labelling with phycoerythrin conjugated anti CD 3 antibody and biotinylated antibodies to activation antigens : human leucocyte antigen ( HLA ) DR , transferrin receptor ( TFR ) or interleukin 2 receptor ( IL 2R ) visualised with an avidin biotin fluorescein system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Regulation of both IL 2 and IFN gamma production as well as transferrin receptor ( TfR ) expression by calcitriol was apparent at the messenger RNA ( mRNA ) level as determined by Northern blotting . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptors ( TfR ' s ) has been investigated in eight liver biopsy specimens ( four from patients without demonstrable iron and four from patients with iron storage due to primary hemochromatosis ( HC ) ) using immunoelectron microscopy to demonstrate TfR ' s by the simultaneous application of two specific monoclonal antibodies ( OKT 9 and B3 / 25 ) to tissue chopper sections . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Membrane transferrin receptor ( TfR ) and nuclear proliferation associated Ki 67 expression in hemopoietic malignancies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Several reports suggest that natural killer ( NK ) cells recognize the transferrin receptor ( TFR ) as a target for killing , and that natural cytotoxicity may be involved in the control of stem cell proliferation in bone marrow . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin and somatomedin C receptors ( TFr and SMCr ) were studied in human ovaries by immunostaining using monoclonal antisera . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Activated lymphocytes expressing transferrin receptors ( TFR ) are present in the peripheral blood in rheumatoid arthritis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Single cell analysis of K 562 human erythroleukemia cells by flow cytometry was used to demonstrate the specific role of iron in regulating transferrin receptors ( TfRs ) and to establish that TfR expression does not necessarily correlate with growth rate . ^^^ TfR expression was negatively correlated with exogenous iron content : any treatment that reduced exogenous iron supply by at least 15 % resulted in as much as a 1 . 8 fold increase in external receptors , detected as binding by both transferrin and monoclonal anti TfR antibodies , and a 1 . 5 fold increase in the pool of internal receptors , as detected by anti TfR antibody binding . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The intracellular movement of cell surface transferrin receptor ( TfR ) after internalization was studied in K 562 cultured human erythroleukemia cells . ^^^ This pathway , which has not been previously described for a cell surface receptor , may be different from the route followed by TfR in iron uptake , since reported rates of transferrin uptake and release are significantly more rapid than the resialylation of asialo TfR . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Multiparameter single cell analysis by flow cytometry was used to distinguish between size related changes in K 562 cell transferrin receptor ( TfR ) expression and changes in membrane receptor density throughout the cell cycle and over time in culture . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A simple and efficient method for the analysis of the affinity and number of functional transferrin receptors ( TFR ) on human tumor cells is described . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , human transferrin receptor ( TfR ) expression , as monitored by flow cytometry using the B3 / 25 monoclonal antibody , demonstrated no clear correlation with NK sensitivity or competitive ability in either KL or YL hybrid clones , thus arguing against the involvement of the TfR in human NK recognition . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
J 64 was shown to immunoprecipitate the transferrin receptor ( TfR ) . ^^^ However , it bound to an epitope different from those recognized by other TfR antibodies and different from the transferrin binding site . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptors ( TFR ) is a good marker of cellular proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Special attention was directed to the density of natural killer ( NK ) like cells using the anti HNK 1 ( Leu 7 ) antibody since the transferrin receptor ( tfr ) or other growth associated membrane structures may serve as target for NK cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin ( TF ) and transferrin receptor ( TFr ) were studied in human testicular biopsy specimens with the use of immunostaining techniques . ^^^ A polyclonal antibody to human TF ( obtained in goat ) , a murine monoclonal antibody ( B3 / 25 ) to human TFr , and antisera antigoat IgG and antimouse IgG , both labeled with peroxidase , were used . ^^^ Transferrin ( TF ) and transferrin receptor ( TFr ) were studied in human testicular biopsy specimens with the use of immunostaining techniques . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , we were unable to inhibit NK lysis by either excess iron saturated Tf or affinity purified TfR . ^^^ A normal host cell glycoprotein , the transferrin receptor ( TfR ) , has been proposed as a target structure on tumor cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Pretreatment of K 562 target cells with intact alpha Fc gamma R mAb or its Fab fragment or anti transferrin receptor ( alpha TFR ) mAb partially blocked in a dose dependent manner , NK activity to K 562 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The proliferation of non neoplastic T lymphocytes is regulated , in part , by the coordinated expression of genes encoding T cell growth factor ( interleukin 2 , IL 2 ) , IL 2 receptors ( IL2R ) , and transferrin receptors ( TFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) has been identified as a marker for proliferation in cells in culture and can be accurately quantitated by specific radioimmunoassay . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) was acted on by mannosidase 1 during reculture , suggesting that it returned to the region of the Golgi complex where this enzyme resides . ^^^ The slow rate of this transport ( t1 / 2 greater than 6 h ) implies that it is probably different than TfR movement during transferrin internalization ( t1 / 2 = 10 20 min ) and TfR transport to the sialyltransferase compartment in the Golgi complex ( t1 / 2 = 2 3 h ) ( Snider , M . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The recycling itinerary of plasma membrane transferrin receptors ( TFR ) was charted in IgG secreting mouse myeloma cells ( RPC 5 . 4 ) by tagging surface receptors with either bound anti transferrin receptor antibodies ( anti TFR ) or Fab fragments thereof and determining the intracellular destinations of the tagged receptors by immunocytochemistry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Despite the direct effect of Tf on NK cells , the number of cells expressing receptors for Tf ( TfR ) in NK enriched LGL was the same as the NK cell depleted high density small lymphocyte population ( SL ) . ^^^ The importance of Tf in NK like development was confirmed by modulating the expression of TfR in IL 2 containing cultures with mouse monoclonal antibody OKT 9 specific for TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Both phorbol ester or diacylglycerol ( DAG ) reduce cell surface transferrin receptor ( TFR ) number in CEM cells ( a human T cell acute lymphoblastic leukemia line ) and HL 60 cells ( a human promyelocytic leukemia cell line ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The proliferation of human T lymphocytes is regulated , in part , by the coordinated expression of genes encoding T cell growth factor ( interleukin 2 ( IL 2 ) , IL 2 receptors , and transferrin receptors ( TFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Upon stimulation with a phorbol ester and known tumour promoter , 12 O tetradecanoylphorbol 13 acetate ( TPA ) , the human erythroleukemia K 562 cell line , a standard target for human natural killer ( NK ) cells , shows a significant reduction in expression of transferrin receptors ( TfR ) and becomes resistant to NK mediated cytolysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of changes in cellular iron metabolism on the surface expression of transferrin receptors ( TfR ) was examined in primary cultures of hepatocytes from adult rats . ^^^ Following 24 h of treatment with the iron chelator , desferrioxamine , or with succinylacetone , an inhibitor of heme synthesis , the number of TfR at the cell surface was increased severalfold , with no significant change in receptor affinity ( KD ) for transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Only antibody W 3 competed with transferrin ( TF ) for binding to TFR . ^^^ Hybridomas secreting monoclonal antibodies to transferrin receptor ( TFR ) were isolated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Human transferrin receptor ( tfR ) is a covalent homodimer of 90 kDa transmembrane subunits , which transits an endocytotic pathway involving exposure to low pH . ^^^ Digestion of purified tfR at neutral pH generates a soluble noncovalent dimer of 70 kDa fragment subunits containing 95 % of the extracellular tfR sequence , including the transferrin binding sites . ^^^ We suggest that tfR clustering in acidic compartments results from self association due to a conformational change that is sensitive to transferrin binding . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Down modulation of the transferrin receptor ( Tfr ) , highly represented on the cell surface , is also observed during the early stages of differentiation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of two membrane glycoproteins , RL 388 antigen and transferrin receptor ( TfR ) , was examined on murine B cells stimulated with lipopolysaccharide ( LPS ) in vitro . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
If in addition to Tf / HRP also an excess of non conjugated transferrin was present in the medium , [ 35S ] c AT was not accessible for Tf / HRP , showing the involvement of the transferrin receptor ( TfR ) in the process . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To evaluate the modulatory effects of trace metals on lymphocyte growth and maturation , thymidine uptake ( TU ) , protein , ATP , Fe , Cu , Zn , ferritin , CD 3 , CD 4 , CD 8 antigens , surface transferrin receptors ( TFR ) and interleukin 2 receptors ( IL2R ) were assessed in normal and T cell leukemia human lymphocytes , cultured in media with varying Fe , Cu and Zn concentrations [ Me ] . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The genes for both these proteins , ferritin and the transferrin receptor ( TfR ) , are regulated at the post transcriptional level , but by entirely different mechanisms . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of the transferrin receptor ( TfR ) was studied on peripheral blood blast cells from 11 patients with acute myeloid leukaemia ( AML ) . ^^^ Using a monoclonal anti TfR antibody ( OKT 9 ) and a polyclonal antibody against surface membrane bound transferrin , a proportion of blasts from all the patients was found to express receptors for transferrin . ^^^ In five out of six samples studied , stimulation of DNA synthesis following short term culture induced a several fold increase in TfR display as analysed by flow cytometry using OKT 9 or FITC conjugated transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Thus , by the time mitogen activated T cells have reached the G1 / S interface , many genes that are transcriptionally silent in G 0 , like the c myc , IL 2 , IL 2 receptor ( IL 2R ) and transferrin receptor ( TfR ) genes , have been transcriptionally activated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptors ( TFR ) by normal and neoplastic urothelial cells was studied in `` control ' ' patients and in patients with transitional cell carcinoma of the bladder . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have studied the transcriptional activity , steady state mRNA levels , and steady state protein levels of the c myc and transferrin receptor ( TfR ) genes in murine M 1 myeloid leukemia cells arrested in G 1 phase of the cell cycle by different methods . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of the transferrin receptor ( TfR ) was studied in the acute leukaemias and lymphoproliferative disorders by means of indirect immunofluorescence and / or the enhanced alkaline phosphatase anti alkaline phosphatase ( APAAP ) techniques using monoclonal antibodies to the receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of an anti human transferrin receptor ( anti TFR ) monoclonal antibody ( MoAb ) , designated B3 / 25 , and an anti melanoma antibody , designated 96 . 5 , on the uptake of gallium 67 ( 67Ga ) by tumor was studied . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of transferrin receptors ( TfR ) by activated lymphocytes is necessary for lymphocyte DNA synthesis and proliferation . ^^^ We studied mechanisms by which lymphoblastoid cells modulate TfR expression during treatment with phorbol diesters or iron transferrin ( FeTf ) , agents which cause downregulation of cell surface TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of a receptor for the serum protein transferrin has been shown to be a characteristic of several cell lineages and increased transferrin receptor ( TFR ) expression to reflect cellular activation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
When transferrin was low ( 0 10 micrograms / ml ) and in serum free medium ( SFM ) , LDL suppressed the expression of cell surface receptors for interleukin 2 ( IL 2R ) and transferrin ( TfR ) , the late blastogenic response prior to DNA replication ( 72 hr ) , and DNA replication . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two rat monoclonal antibodies to the murine transferrin receptor ( TFR ) were each conjugated to recombinant ricin toxin A chain ( rRTA ) . ^^^ The monoclonal antibodies , R 17 217 and YE1 / 9 . 9 , bound to partially overlapping antigenic determinants on the murine TFR that were distinct from the transferrin binding site . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the majority of human cells the transferrin receptor ( TFR ) plays an important role by mediating the cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We compared transferrin receptor ( TfR ) expression on human peripheral blood lymphocytes ( PBL ) activated by phorbol myristate acetate ( PMA ) or L phytohemagglutinin ( LPHA ) using two techniques : ( 1 ) 125I iron saturated transferrin ( FeTf ) binding , ( 2 ) reactivity with monoclonal anti TfR antibodies OKT 9 and B3 / 25 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The estimated TFR ( 0 . 75 ) results from the assumed total fecundity ( TF ) of 15 . 30 births / woman being inhibited by the indexes of the proximate determinants of fertility , most notably non marriage ( . 280 ) , contraception ( . 315 ) , and induced abortion ( . 586 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The role of target cell transferrin receptors ( TfR ) in natural killer ( NK ) cell induced cytolysis has been studied using Colo 205 cells in which prior exposure to 60 Hz electromagnetic fields produced constitutive expression of maximum numbers of TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HL 60 cells in serum und Tf free medium displayed 3 times less TfR than cells in serum or Tf containing medium . ^^^ Serum free cultures of HL 60 promyelocytic leukemia cells and cultured fresh leukemia and normal marrow cells were used to investigate relationships between proliferation , transferrin receptor ( TfR ) display and intracellular ferritin ( Fer ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two different experimental approaches based on the specificity of monoclonal antibodies ( mAbs ) have been taken to verify the hypothesis that the transferrin receptor ( TfR ) on proliferating cells serves as a common target structure for natural killer ( NK ) cells . ^^^ The effect of removal of the TfR was controlled by uptake of radiolabeled transferrin , and by binding of non cross reacting monoclonal anti TfR receptor antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The gene for TF therefore maps to the same region as the gene for transferrin receptor ( TFR ) thereby defining an iron transport region on 3q2 to which the transferrin related tumor associated antigen p 97 may also belong . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) was recently proposed as putative natural killer ( NK ) cell target structure . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) mRNA expression is tightly linked to intracellular iron levels . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Concomitantly , the expression of interleukin 2 receptor alpha chain ( IL 2R alpha chain ) , transferrin receptor ( TfR ) , and major histocompatibility complex class 2 molecule HLA DR on the surface of phytohemagglutinin activated T cells from whole blood culture cells ( WBCC ) significantly decreased within 72 h , that is at least two cell cycles , whereas unstimulated T cells from WBCC did not express these markers but had lost their CD 3 molecules , an effect reported to precede apoptosis as part of a T cell inactivation pathway . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously shown that the hepatic acute phase protein alpha 1 antitrypsin ( alpha 1 AT ) inhibits transferrin ( tf ) binding to its receptor ( tfR ) of human placental membranes . ^^^ To evaluate the possibility that this interaction can explain the pathophysiology of the changes in iron metabolism in the course of chronic disease , subsequently leading to anemia in chronic disease ( ACD ) , we examined the effect of alpha 1 AT on cells of the erythroid cell line . alpha 1 AT completely prevented tf binding to tfR on K 562 human erythroleukemic cells and on reticulocytes . ^^^ Internalization of the tf tfR complex was inhibited with alpha 1 AT in a dose dependent manner . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We evaluated the use of transferrin receptor ( TfR ) in serum as an index of iron deficiency in 19 patients diagnosed as having iron deficiency anemia , in 17 patients with anemia of chronic disease , and in a control group of 19 nonanemic patients who underwent elective ocular or nasopharyngeal surgery . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We assessed its capacity to induce markers of the passage of T cells from the resting ( G 0 ) state into the G 1 phase of the cell cycle , such as receptors for IL 2 ( IL 2R ) and transferrin ( TFR ) and class 2 major histocompatibility complex antigens ( HLA DR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Reticulocytes were isolated from unfractionated cells and from each density fraction with an immunomagnetic technique directed against transferrin receptors ( TfR ) and assayed for the percentage of HbF and K+ / Hb ratio . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although IRPs have been shown to bind to IREs derived from ferritin and transferrin receptor ( TfR ) mRNAs in vitro , there has not been a direct demonstration of the impact of a recombinant IRP on the expression of endogenous IRE containing transcripts . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The correlation of RMI to serum erythropoietin ( Epo ) and serum transferrin receptor ( TfR ) was analyzed in a subset of anemic blood samples . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Scatchard plot analysis revealed that this impaired Tf binding in IFN beta treated macrophages was not due to a decreased affinity of the TfR for its ligand but to a reduction in the number of cell surface TfR . ^^^ IFN gamma did not exert any significant effect on the expression of TfR , even though it was capable of partially reverting the inhibitory effect of the IFN beta on Tf binding . ^^^ To understand the mechanism by which IFN beta inhibited TfR expression , we examined the expression of TfR mRNA , 125I Tf binding to detergent solubilized cells , and TfR cellular distribution . ^^^ We evaluated the effect of IFN beta on the expression of transferrin receptor ( TfR ) during the in vitro differentiation of peripheral blood monocytes to macrophages . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transport to these sites was studied by example of the transferrin receptor ( TfR ) and the serine peptidase dipeptidylpeptidase 4 ( DPPIV ) after labeling these proteins with the N hydroxysulfosuccinimide ester of biotin on the cell surface . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The incubation with CP significantly reduced the expression of the low affinity interleukin 2 receptor ( IL 2R alpha chain ) and of transferrin receptor ( TfR ) on PHA stimulated T lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We studied the role of endosomes acidification on the endocytic trafficking of the transferrin receptor ( TfR ) as a representative for the recycling pathway , the cation dependent mannose 6 phosphate receptor ( MPR ) as a prototype for transport to late endosomes , and fluid phase endocytosed HRP as a marker for transport to lysosomes . ^^^ Sorting between endocytosed TfR and MPR was analyzed by the HRP catalyzed 3 , 3 ' diaminobenzidine cross linking technique , using transferrin conjugated to HRP to label the endocytic pathway of the TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cytoplasmic ferrochelatase mRNA and transferrin receptor ( TfR ) mRNA levels are only insignificantly increased in Fw cells after induction . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Thus , CD34+ HPC entering in cycle ( S / G2M ) after a 48 h pulse with IL 3 expressed the transferrin receptor ( TfR ) , and fluorescence activated cell sorter separated TfR+ HPC , but not TfR HPC , showed a high proliferative response to IL 3 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The determination of plasma transferrin receptor ( TfR ) in patients with heart valve prosthesis : a useful evaluation of bone marrow response to traumatic haemolysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Toward this end , plasma concentrations of interleukin 1 beta ( IL 1 beta ) and IL 6 , soluble IL 2 receptor ( sIL 2R ) , and transferrin receptor ( TfR ) were measured in 28 normal controls , 11 schizophrenics and 13 major depressed patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , substitution of the transferrin receptor ( TfR ) internalization sequence by the CD 3 epsilon motif still allowed the rapid internalization of the TfR and , conversely , the chimeric protein resulting from the substitution of the CD 3 epsilon motif by the endocytosis signal of the low density lipoprotein receptor was ER located . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TfR ) contains three N linked oligosaccharides and glycosylation is required for the proper folding and function of the molecule . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mRNA of transferrin receptor ( TfR ) is constitutively expressed in proliferating human leukaemic HL 60 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Liver tissues of the rats were immunohistochemically and histochemically stained for transferrin receptor ( TfR ) , transferrin ( Tf ) , ferritin ( Ft ) , and iron . ^^^ The staining intensity of TfR , Tf and Ft increased in hepatocytes of iron deficient rats and decreased in that of the iron overloaded in comparison with the control rats . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hepatic tissues from these iron deficient , overloaded and control rats were examined for transferrin receptor ( TfR ) , transferrin ( Tf ) and iron after immunohistochemical staining . ^^^ TfR and Tf were mainly distributed in the peripheral part of the lobule ( zone 1 ) in the normal , iron deficient and iron overloaded rats . ^^^ The difference of Tf staining between the three groups of rats was similar to that of TfR . ^^^ In the iron overloaded rats , the staining intensity of iron was stronger in zone 1 than in zone 2 and 3 , similar to the distribution pattern of TfR and Tf . ^^^ These findings suggest that ( 1 ) iron uptake in hepatic cells in vivo is regulated and mediated by TfR and Tf , ( 2 ) the expression pattern of TfR and Tf in zone 1 to zone 3 liver cells may result in the progressive decrease of iron deposition in the hepatic lobules of the iron overloaded rats . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To better understand the cellular and molecular mechanisms by which receptor cross linking affects the intracellular trafficking of both ligand and receptor , we studied the intracellular trafficking of the transferrin receptor ( TfR ) bound to multivalent transferrin ( Tf 10 ) which was prepared by chemical cross linking of transferrin ( Tf ) . ^^^ The retained Tf 10 was TfR associated as demonstrated by a reduction in surface TfR number when cells were incubated with Tf 10 . ^^^ Retention of Tf 10 within the recycling compartment did not require the cytoplasmic domain of the TfR since Tf 10 exited cells with the same rate when bound to the wild type TfR or a mutated receptor with only four amino acids in the cytoplasmic tail . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Exposure of cells to H2O2 leads to reduced synthesis of the intracellular iron storage protein ferritin and stimulates transferrin receptor ( TfR ) mRNA expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The topological relationship of transferrin receptor ( TfR ) has been studied relative to the heavy and light chains of the HLA class 1 molecules , class 2 molecules , interleukin 2 receptor alpha chain and ICAM 1 molecule in the plasma membrane of HUT 102B2 T and JY B lymphoblastoid cell lines using the flow cytometric fluorescence energy transfer technique ( FCET ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Plasma levels of interleukin ( IL ) 1 beta , IL 6 , soluble IL 6 receptor ( sIL 6R ) , sIL 2R , and transferrin receptor ( TfR ) , and baseline plasma cortisol levels were measured in 19 OCD patients and 19 normal controls . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
LPS activation of murine macrophages induced a downshift in transferrin receptor ( TfR ) expression and reduction in cellular iron content , and this was correlated with augmented intracellular growth of Legionella in the cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum transferrin receptor ( TfR ) , a quantitative measure of erythropoiesis , increased progressively over 6 weeks to reach a plateau phase at about twice baseline values . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition to being an iron transporter , the transferrin receptor ( TfR ) has been shown to play a role in T cell activation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cellular iron metabolism comprises pathways of iron protein synthesis and degradation , iron uptake via transferrin receptor ( TfR ) or release to the extracellular space , as well as iron deposition into ferritin and remobilization from such stores . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) appears in vigorously proliferating cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is expressed in the proliferating cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Other cell surface antigens analyzed such as CD 2 , CD 7 , or transferrin receptor ( TfR ) were not affected by the introduction of HIV 1 Nef 27 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously reported that hepatitis B envelope antigen ( HBenvAg ) can be internalized by T cells via transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The stability of transferrin receptor ( TfR ) mRNA is regulated by iron availability . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The serum transferrin receptor ( TfR ) level reflects iron status and the rate of erythropoiesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Intracellular iron homeostasis is modulated by ferritin and transferrin receptor ( TfR ) . ^^^ The addition of excess iron ( as 100 micrograms / ml holo transferrin ) caused reduction of the level of TfR mRNA , however , the iron chelator defferoxamine caused its increase . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) concentration was 2 . 8 + / 0 . 2 mg / l ( mean + / S . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of the structural proteins of the human immunodeficiency virus type 1 ( HIV 1 ) , the human T cell leukemia virus type 1 ( HTLV 1 ) , and of the transferrin receptor ( TfR ) mRNA depends on posttranscriptional regulatory mechanisms involving both positive and negative elements . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transmembrane protein , transferrin receptor ( TfR ) , is found in a soluble form in human serum and in the medium of cell lines grown in tissue culture . ^^^ We used two mutant human TfRs expressed in Chinese hamster ovary ( CHO ) cells lacking endogenous transferrin receptor to characterize the protease that cleaves the TfR and determine its location in the cell . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Untreated microvessels express no endothelial activation antigens , but do exhibit constitutive expression of the transferrin receptor ( tfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have used intensified fluorescence video microscopy to study the redistribution of cell surface receptors , including transferrin receptors ( TFR ) and low density lipoprotein receptors ( LDL R ) , in response to externally applied alternating current electric fields in the 3 to 23 V / cm range ( peak to peak ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we report that T TIL from patients with renal cell carcinoma ( RCC ) also have a defect in transferrin receptor ( TfR ) expression that is not present in T PBL cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated whether determination of serum transferrin receptor ( TfR ) is useful for detecting iron deficiency in patients with chronic inflammatory diseases and for differentiating between iron deficiency anaemia and anaemia of inflammation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Monoclonal antibodies directed against early ( receptors for interleukin 2 and transferrin [ IL 2R , TfR ] ) and late ( PTA 1 , alpha 1 integrin VLA 1 ) activation antigens were used as probes to monitor cardiac transplant patients for episodes of acute graft rejection . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of enterocyte like differentiation on the transferrin receptor ( TfR ) polarity in filter grown Caco 2 cells was studied . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptors ( TfR ' s ) on the syncytiotrophoblast mediate transferrin ( Tf ) dependent Fe uptake and transfer to the fetus . ^^^ We studied TfR number and density at the microvillous membrane isolated from guinea pig placentas at day 40 , 50 and 64 ( near term ) , together with the K ( a ) values for the main serum isotransferrins being biantennary Tf ( slow ) and triantennary Tf ( fast ) . ^^^ Desialylation of Tf ( slow ) and Tf ( fast ) had no effect on K ( a ) nor on the number of TfR . ^^^ Transferrin receptors ( TfR ' s ) on the syncytiotrophoblast mediate transferrin ( Tf ) dependent Fe uptake and transfer to the fetus . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To quantify changes in their antigenic profile , pulse labeled macropinosomes of different ages were fixed and stained for immunofluorescence with a panel of antibodies specific for the transferrin receptor ( TfR ) , the late endosome specific , GTP binding protein rab 7 or lysosomal glycoprotein A ( lgp A ) , and the percentage of antibody positive , FDx10f labeled macropinosomes was scored . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) expression is regulated by iron at the level of mRNA stability through a factor ( IRF / IRE BP ) which binds to specific iron responsive elements ( IRE ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A recently introduced test measures the concentration of transferrin receptor ( TfR ) in serum , which increases shortly after the onset of iron deficiency . ^^^ No associations were observed between the serum TfR and the concentration of Hb , the values of packed cell volume , reticulocyte production index , mean corpuscular Hb , mean corpuscular volume , or the concentrations of serum iron , transferrin , or ferritin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In proliferating non erythroid cells , the expression of transferrin receptors ( TfR ) is negatively regulated by the amount of intracellular iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In these studies , murine G 0 T cells activated by immobilized anti CD 3 and subsequently blocked in late G 1 expressed normal surface levels and mRNA for IL 2R alpha , IL 2R beta , and transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Immunohistochemistry showed transferrin receptor ( TfR ) , Ki 67 , and epidermal growth factor receptor ( EGFR ) in OKK TKm , but less or none in OKK TKp . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Because of the association between T lymphocyte chemotactic and growth factor activity , in the current study , we investigated the effect of ED LCA on T cell growth by assessing its capacity to induce markers of the passage of T cells from the resting ( G 0 ) state into the G 1 phase of the cell cycle , such as receptors for IL 2 ( IL 2R ) and transferrin ( TFR ) , and class 2 major histocompatibility complex antigens ( HLA DR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In order to clarify the role and interrelationship of c myc , interleukin 2 ( IL 2 ) , and transferrin receptor ( TfR ) expressions on PHA stimulated lymphocyte proliferation , we examined the effects of antisense oligodeoxynucleotides directed against c myc , TfR , and IL 2 mRNAs on DNA synthesis and cell cycle phase . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Herein , we report that binding to soluble ferric Tf by HBenvAg is needed in TfR mediated endocytosis . ^^^ In a previous study , we identified that transferrin receptor ( TfR ) is the receptor utilized by hepatitis B virus ( HBV ) to enter T cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
AIMS To investigate the proliferative activity ( given by the Ki 67 index ) of the normal , atypical , and neoplastic urothelium and its relation to the cellular reactivity for the epidermal growth factor ( EGFr ) and transferrin ( Tfr ) receptors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We measured the soluble ( s ) receptors CD 23 , CD 8 , CD 4 , interleukin 2 receptor ( IL 2R , CD 25 ) , and transferrin receptor ( TfR , CD 71 ) , in normal serum and in patients with chronic lymphocytic leukemia ( CLL ) and evaluated them in relation to clinical and biological parameters of the disease , as well as serum immunoglobulin E ( IgE ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
All responding patients had low but detectable pretreatment circulating erythroid progenitor cells ( BFU E ) and the response to rhEPO was associated with a significant increase in BFU E ( p < 0 . 01 ) ; concentrations of serum transferrin receptor ( TfR ) also consistently rose in all responding patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) is the plasma membrane protein responsible for the binding and internalization of the major iron transport protein , transferrin . ^^^ A 78 kD soluble TfR that can bind transferrin is released into the growth medium . ^^^ The intact mutant TfR is not grossly altered in its structure and does not differ significantly from the wild type human receptor in many respects : ( 1 ) It shows the same distribution between the plasma membrane and intracellular compartments ; ( 2 ) the binding constant for transferrin is similar to that of the wild type TfR ; and ( 3 ) it is not rapidly degraded . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although the observed / predicted ratio for serum transferrin receptor ( TfR ) concentration was low in 12 of 19 MDS subjects , no relationship to haemoglobin concentration , reticulocytes or serum EPO was seen . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Mouse erythroleukemia Friend cells induced to undergo erythroid differentiation by treatment with hexamethylenebisacetamide ( HMBA ) were shown to increase cytoplasmic ferrochelatase mRNA , transferrin receptor ( TfR ) mRNA and glutathione peroxidase ( GSHPx ) mRNA levels . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Microvessels prepared from MS brain with plaque involvement expressed decreased factor 8 and increased transferrin receptors ( tfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory elements ( IREs ) are a family of 28 nucleotide , non coding elements which regulate the translation of ferritin mRNA ( iron storage ) , erythroid delta aminolevulinic acid synthase mRNA ( heme synthesis ) and the stability of the transferrin receptor ( TfR ) mRNA ( iron uptake ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) follows complex pathways of transport after endocytosis from the cell surface . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Gallium binds to the iron transport protein transferrin ( Tf ) , is incorporated into cells through transferrin receptors ( TfR ) and inhibits iron dependent DNA synthesis . ^^^ Since cellular TfR expression is tightly regulated by the availability of iron , we investigated the effects of transferrin gallium ( Tf Ga ) on TfR mRNA levels in myeloid HL 60 and lymphoid CCRF CEM cells . ^^^ In HL 60 cells , Tf Ga increased TfR mRNA levels in a dose dependent fashion . ^^^ This increase in TfR mRNA was blocked by Tf Fe and by cycloheximide . ^^^ Analysis of the rate of mRNA decay in the presence of actinomycin D revealed that the half life of TfR mRNA was increased in HL 60 cells incubated with Tf Ga . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We found that cytochrome c ( c ) covalently coupled to monovalent iron saturated transferrin ( Tf ) , ( c Tf ) , is not processed or presented significantly better than unconjugated c , indicating that the majority of cycling TfR does not enter compartments where processing proceeds . ^^^ The conjugation of Tf to c does not affect its binding to the TfR , as the binding is both saturable and compatible with unmodified Tf . ^^^ Significantly , we found that c Tf is efficiently processed and presented when the TfR is cross linked , altering its normal cycling . ^^^ Cross linking of c Tf bound to the TfR using c specific antibodies also results in efficient processing and presentation . ^^^ Here we report that Ag bound to the transferrin receptor ( TfR ) , which cycles predominantly through early endosomal compartments , does not enter the processing pathway . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum transferrin receptor ( TfR ) levels were measured in 182 children with homozygous sickle cell ( SS ) disease , 47 with sickle cell haemoglobin C ( SC ) disease and 41 normal ( AA ) controls on their eighth birthday . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The best prediction by pretreatment parameters only was obtained with baseline serum transferrin receptor ( TfR ) ( < or > or = 3 , 500 ng / mL ) and fibrinogen ( < or > or = 4 g / L ) : 100 % response rate when both parameters were low , versus only 29 % when they were both high , and versus 67 % when one was low and the other high . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The RBC mass was quantitated by direct isotopic measurement ( RCM ) , Epo production by serum Epo levels , and erythropoiesis by the ferrokinetic measurement of the erythron transferrin uptake ( ETU ) , the serum transferrin receptor ( TfR ) level , and the reticulocyte ( retic ) index , and was completed by an evaluation of overall marrow erythron cellularity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HL 60 cells , grown in medium with FBS , were found to have an 8 . 4 fold increase in surface transferrin receptor ( TfR ) expression ( P < 0 . 001 ) as compared with HL 60 cells grown in medium with HPS . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Binding of IRF to iron responsive elements ( IRE ) in the 5 ' untranslated region ( UTR ) of ferritin and erythroid 5 aminolevulinic acid synthase mRNAs inhibits their translation , whereas binding to IREs in the 3 ' UTR of transferrin receptor ( TfR ) mRNA prevents the degradation of this mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
It has recently become evident that elevation of reticulocytes in the circulation of several species , including humans , leads to the formation of a noncellular transferrin receptor ( TFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
During induced differentiation and maturation of HD 3 cells ( a chicken erythroblast cell line infected with a temperature sensitive mutant of the avian erythroblastosis virus ) , the levels of transferrin receptor ( TFR ) and nucleoside transporter increase . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is a membrane receptor involved in the control of iron supply to the cell through the binding of transferrin , the major iron carrier protein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated the respective role of marrow function and erythropoietin production in 31 ABMT and 47 allogeneic BMT by analysing peripheral counts , serum erythropoietin levels , and serum transferrin receptor ( TfR ) levels which have been shown to be a quantitative measurement of erythropoiesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Soluble transferrin receptors ( sTfR ) were detected in culture supernatants of activated human peripheral blood mononuclear cells ( PBMC ) using a sandwich ELISA technique with two non cross reacting TfR MoAbs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Interleukin 2 ( IL 2 ) controls the proliferation of the murine T cell line B6 . 1 and induces transferrin receptor ( TfR ) mRNA steady state levels 50 fold when added to arrested , IL 2 deprived cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two major proteins in this vesicle fraction isolated from all cell types are the transferrin receptor ( TfR ) and the mannose 6 phosphate / IGF 2 receptor ( MPR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The bispecific murine monoclonal antibody ( MAb ) 1A10 has specificity for the human transferrin receptor ( TfR ) and the human tumor associated antigen gp 40 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The purpose of this study was to investigate the plasma concentrations of interleukin ( IL ) 6 , soluble IL 6 receptor ( sIL 6R ) , sIL 2R and transferrin receptor ( TfR ) in patients with major depression in an acute phase of illness , in remission and during antidepressive treatment . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have followed the transfer of EGF EGF receptor ( EGFR ) complexes from endosomal vacuoles that contain transferrin receptors ( TfR ) to lysosome vacuoles identified by their content of HRP loaded as a 15 min pulse 4 h previously . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mechanism involved in the regulation of transferrin receptor ( TfR ) expression during phorbol ester induced HL 60 cell differentiation was investigated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using an anti GLUT 4 monoclonal antibody we immunoisolated a vesicular fraction from an intracellular membrane fraction of 3T3 L 1 adipocytes that contained > 90 % of the immunoreactive GLUT 4 found in this fraction , but only 40 % of the transferrin receptor ( TfR ) . ^^^ Using a technique to cross link and render insoluble ( `` ablate ' ) intracellular compartments containing the TfR by means of a transferrin horseradish peroxidase conjugate ( Tf HRP ) , we further examined the relationship between the endosomal recycling pathway and the intracellular compartment containing GLUT 4 in these cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the whole group serum transferrin receptor ( TfR ) levels remained stable , but increased after the cessation of iron dextran only in the rHuEPO treated patients ( p < 0 . 01 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) mRNA levels were increased in cells treated with NO . generating compounds , but not in cytokine and LPS treated cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this paper we have attached the C terminus of 2C11 sFv ( anti mouse CD 3 epsilon chain ) to the N terminus of OKT 9 sFv ( anti human transferrin receptor [ TfR ] ) through a 23 amino acid inter sFv linker consisting primarily of CH 1 region residues from 2C11 , to form a single chain bispecific Fv 2 [ bs ( sFv ) 2 ] molecule . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
While this resulted in ablation of > 90 % of the transferrin receptor ( TfR ) and cellubrevin found in intracellular membranes , 60 % of GLUT 4 and 90 % of VAMP 2 was not ablated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A soluble form of the human transferrin receptor ( TfR ) resulting from proteolytic cleavage at Arg 100 has been measured in human blood . ^^^ Otherwise the properties of the mutant TfRs were indistinguishable from the wild type TfR in that the affinity of transferrin for these receptors , the extent of disulfide bond formation of the TfRs , and the proportion of TfRs at the cell surface were similar to that of the wild type TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cleavage of the transferrin receptor by human granulocytes : differential proteolysis of the exosome bound TFR . ^^^ In contrast with other mammalian granulocytes , human granulocytes rapidly cleave the transferrin receptor ( TFR ) from sheep exosomes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The modulation of cellular iron metabolism depends on the expression of ferritin and transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Both the plasma determinations of erythropoietic ( EPO ) and transferrin receptor ( TfR ) would provide a good characterization of anemia especially when mixed erythron disorders underlie , such as in renal failure . ^^^ Immunologic assays of EPO and TfR , as well as standard hematologic determinations ( hematocrit , reticulocyte count , serum iron , transferrin , ferritin ) were performed in patients with chronic renal failure ( CRF ) , in regular dialysis treatment ( RDT ) and in transplanted ( TX ) patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of this study was to examine the capacity of the syncytiotrophoblast to regulate transferrin receptor ( TfR ) synthesis in response to modulations in maternal iron supply . ^^^ These results show that the differentiating trophoblast cells respond to pertubations in the ( transferrin mediated ) iron supply by adjustments in the rate of TfR synthesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human placenta transferrin receptor was purified in the form of transferrin transferrin receptor complex ( Tf TfR ) , and a monospecific polyclonal antibody against TfR was developed by a Tf coupled Sepharose 4B affinity chromatography to remove the anti Tf components in the antiserum . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
With the aim of selectively increasing 67Ga uptake , we studied whether the transferrin receptor ( TfR ) expression could be modulated in the U 937 and U 715 lymphoma cell lines by cytostatic drugs inducing cell cycle phase accumulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Culture for 65 h in diferric transferrin enriched medium resulted in intermediate TfR densities together with an intermediate kend ( 0 . 210 min 1 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The role of TFR and transferrin ( TF ) in Ga ( NO 3 ) 3 cellular uptake was also tested . ^^^ Both exogenous and endogenous TF and TFR play an important role in Ga uptake in these cells . . ^^^ The effect of a combination of anti transferrin receptor ( TFR ) antibody , 42 / 6 , and Ga ( NO 3 ) 3 on cell growth was examined in small cell lung cancer ( SCLC ) cell lines : classic , NCI H 209 , NCI H 345 , NCI H 510 ; and variant , NCI H 82 and NCI N 417 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A similar 97 , 000 M ( r ) protein was eluted from a column containing immobilised bovine transferrin ( Tf ) using conditions known to elute the human TfR , and this protein was recognised by mAb IL A 77 , proving that it detected bovine TfR . ^^^ A murine IgM monoclonal antibody ( mAb ) , IL A 77 , has been generated that recognises the bovine transferrin receptor ( TfR ) and will be a useful tool to measure the activation state of bovine lymphocytes and macrophages . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In order to evaluate the contribution of internalization rate and receptor number on immunotoxin potency , the effects of an anti ( transferrin receptor , TfR ) / ricin A chain immunotoxin , 7D3 A , were assessed on a parent Chinese hamster ovary cell line developed in our laboratory with no TfR ( TfRneg ) and two lines transfected with either wild type TfR ( Tfrwt ) or an internalization deficient ( TfR ( delta 7 58del ) ) mutated human TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To study the effects of nitric oxide ( NO ) on the expression of three genes involved in erythroid cell iron metabolism ( gamma globin , H ferritin , and transferrin receptor [ TfR ] ) , we developed a series of human K 562 erythroleukemic cell clones retrovirally transduced with inducible nitric oxide synthase ( NOS 2 ) and producing different steady state levels of NO . gamma Globin and H ferritin protein expression was reduced in NO producing cells in relation to the amount of NO produced . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study revealed that the major part of soluble TfR was saturated by transferrin ( Tf ) in serum , forming a stable complex which was more immunoreactive than intact TfR . ^^^ Thus , we proposed that serum soluble TfR should be measured as the TfR Tf complex ( TRC ) , using prepared TRC for assay standardization . ^^^ The transmembrane protein , transferrin receptor ( TfR ) , exists in serum as a soluble form that lacks cytoplasmic and transmembrane domains ( residues 1 100 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Diferric transferrin ( Tf ; 80K mol . wt . ) and the OX 26 antibody ( 150K mol . wt . ) against the transferrin receptor ( TfR ) were evaluated in the rat at light and ultrastructural levels as potential vehicles for the blood to brain transcellular transfer ( transcytosis ) of native horseradish peroxidase ( 40K mol . wt . ) , which by itself does not cross the blood brain barrier ( BBB ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum levels of the transferrin receptor ( TfR ) were monitored in 12 anemic patients with rheumatoid arthritis ( RA ) undergoing treatment with recombinant human erythropoietin ( rHuEPO ) for a 24 week period . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this investigation , sickle RBCs were deoxygenated either continuously or in 15 minute cycles for 4 hours , and the density increases of very young , transferrin receptor positive ( TfR+ ) cells and the remaining TfR cells were determined . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Plasma concentrations of interleukin 6 ( IL 6 ) , soluble IL 6 receptor ( sIL 6R ) , soluble interleukin 2 receptor ( sIL 2R ) , transferrin receptor ( TfR ) , C reactive protein ( CRP ) , and alpha 1 acid glycoprotein ( AGP ) , as well as the microheterogeneity of AGP , were measured in 49 major depressed patients during an acute phase of the illness and compared with concentrations in 15 normal control subjects . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron overload produced a decrease in transferrin receptor ( TfR ) mRNA in the duodenum , with ferritin mRNA levels unaffected in both the duodenum and ileum . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The close , but non covalent , association of hsp 70 with the transferrin receptor ( TFR ) in exosomes is demonstrated by : ( 1 ) the ability to cross link hsp 70 to TFR ; ( 2 ) the co immunoprecipitation of hsp 70 and TFR with an antibody against TFR , and the co immunoprecipitation of TFR and hsp 70 with antibody against hsp 70 ; and ( 3 ) the retention of TFR by hsp 70 bound to ATP agarose and the simultaneous elution of both proteins by excess ATP . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The insulin Tf conjugate ( insulin Tf ) was tested for the transport of insulin across enterocyte like Caco 2 cell monolayers by the process of transferrin receptor ( TfR ) mediated transcytosis . ^^^ The uptake of insulin Tf in Caco 2 cells was TfR mediated but no insulin receptor mediated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mRNA levels for the membrane receptor for iron uptake , transferrin receptor ( TfR ) , decrease following stimulation with IFN gamma / LPS , although IRP mediated stabilization of the TfR mRNA would have been expected . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The serum transferrin receptor ( TfR ) level was markedly increased , an indication of increased erythropoietic activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Interactions between these sequences and components of the endocytic machinery should become limiting upon overexpression of the constitutively recycling transferrin receptor ( TfR ) . ^^^ Internalization assays indicate the rate of 125I transferrin uptake per surface TfR is reduced by a factor of 4 in induced cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By indirect immunofluorescence , the transferrin receptor ( TfR ) , a component of early endosomes , and the cation independent mannose 6 phosphate receptor ( CI M6PR ) , a component of late endosomes , were found in close association with the chlamydial vacuole as early as 4 h postinfection ( hpi ) and as late as 20 hpi . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptors ( TfR ) were detected in brain and liver endothelial cells ( EC ) ; however , little information exists about their intracellular routes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The objective of the study was to evaluate the diagnostic efficiency of laboratory tests , including serum transferrin receptor ( TfR ) measurements , in the diagnosis of iron depletion . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Circulating transferrin receptor ( TfR ) levels 30 days after BMT were also significantly higher in the HD Epo group than in the other . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated the components of biological variation in serum soluble transferrin receptor ( TfR ) in relation to serum iron , transferrin ( Tf ) , ferritin , soluble interleukin 2 receptor ( sIL 2R ) , sIL 6R , and number of erythrocytes , haemoglobin ( Hb ) , haematocrit ( Ht ) , mean corpuscular volume ( MCV ) , mean cell haemoglobin ( MCH ) , and erythrocyte distribution width ( RDW ) . ^^^ The estimated CVs for TfR were interindividual CVg = 20 . 8 % , and intra individual CVi = 13 . 6 % ; for Tf , CVg = 14 . 4 % and CVi = 6 . 7 % ; for iron , CVg = 16 . 8 % and CVi = 29 . 2 % ; and for ferritin , CVg = 71 . 1 % and CVi = 26 . 5 % . ^^^ The peak trough differences in the yearly variations , expressed as a percentage of the mean , were : for TfR , 11 . 7 % ; for iron , 39 . 2 % ; for Tf , 11 . 7 % ; and for ferritin , 29 . 3 % . ^^^ Up to 34 . 2 % of the within subject variability in TfR ( which reflects changes over time ) could be explained by the regression on iron , ferritin , Tf , sIL 2R , sIL 6R and MCH values . ^^^ Up to 67 . 2 % of the between subject variability in TfR ( which reflects differences in the homeostatic setpoint during the study year ) could be explained by the regression on gender , iron , Tf , and ferritin values . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TfR ) has three N linked oligosaccharides . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Ten patients , who received cadaveric kidneys , were followed for 24 wk with serial measurements of serum erythropoietin ( S Epo ) , transferrin receptor ( S TfR ) and iron variables . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Defective bone marrow activity , demonstrated by low transferrin receptor ( TfR ) , and hypoferremia in spite of abundant iron stores were also shown . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To determine the total day to day intraindividual variability of ferritin and transferrin receptor ( TfR ) , we collected venous serum and plasma and capillary serum and plasma samples during 10 nonconsecutive days over a 4 wk period from a group of healthy men ( n = 10 ) and women ( n = 11 ) aged 19 46 y . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The re alpha sarcin was used in the construction of an active immunotoxin targeted at the human cancer cells overexpressing transferrin receptor ( TFR ) . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptor ( TfR ) has been identified in many malignant tumours . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Binding studies showed that pretreatment with either of the phosphatase inhibitors did not result in significant changes in the K ( d ) for Tf binding to transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using a doxorubicin resistant subline ( K562 / ADM ) of human leukaemia K 562 cells ( Tsuruo et al , 1986 ) , the effect of immunoliposomes that targeted a cellular transferrin receptor ( TFR ) was examined by neutralization of doxorubicin ( DOX ) resistance . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TFR ) has been detected in tissues characterised by a high degree of proliferation . ^^^ We have developed a procedure for isolating TFR from human placental tissues by affinity chromatography on transferrin Sepharose . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To establish percentile estimates of transferrin receptor ( TfR ) for healthy infants , plasma TfR was measured in 485 healthy infants 9 15 mo of age from Edmonton , Toronto , Montreal , and Halifax . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Membranes from the F 30 fraction were highly enriched in transferrin receptor ( TfR ) and annexin 2 , two markers of the early endosome compartment , whereas they were significantly depleted of both GLUT 1 and the alpha 1 subunit of ( Na++K+ ) ATPase , two cell surface markers . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although transferrin receptor ( TfR ) expression is increased , binding to diferric transferrin is decreased proportionately to the severity of maternal disease . ^^^ It is hypothesized that TfR isolated from diabetic placentae has altered N glycosylation since proper glycosylation of N linked oligosaccharides is important for normal TfR binding kinetics to diferric transferrin . ^^^ Competitive binding to 125I transferrin demonstrated a higher Kd in the diabetic TfR ( P = 0 . 04 ) , directly correlated to cord serum C peptide concentration ( r = 0 . 81 , P < 0 . 001 ) . ^^^ Increased glycosylation of the N linked oligosaccharides of TfR isolated from diabetic placentae may alter the three dimensional structure or charge of the receptor , thus reducing its binding affinity for transferrin . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Endocytosis of the Tf / TfR complex is essentially the only pathway active in maturing reticulocytes , while exosomes , formed by invagination of the endosomal membrane , provide a mechanism to eliminate seemingly obsolescent proteins , including the TfR , when their function is completed . ^^^ To this end , the flow of two exogenously inserted fluorescent lipid analogs , N ( N [ 6 [ ( 7 nitrobenz 2 oxa 1 , 3 diazol 4 yl ) amino ] caproyl ] ) sphingomyelin ( C 6 NBD SM ) and N ( lissamine rhodamine B sulfonyl ) phosphatidyl ethanolamine ( N Rh PE ) was monitored and compared to that of the transferrin ( Tf ) / Tf receptor ( TfR ) complex . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HQ , but not catechol , caused a decrease in transferrin receptor ( TfR , CD 71 ) expression , comparable to the level observed in IL 2 starved cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study was carried out in order to examine serum IL 6 , IL 6R , CC 16 , IL 1R antagonist ( IL 1RA ) , transferrin receptor ( TfR ) and sCD 8 antigen , both before and after treatment with clozapine in schizophrenic subjects versus normal controls . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron uptake by mammalian cells is mediated by the binding of serum Tf to the TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A number of standard hematologic measurements in addition to automated reticulocyte counts ( Sysmex R 1000 ) and serum transferrin receptors ( TfR ) were obtained in these patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
First , we examine the role of mRNA half life , by studying the distribution of the mRNA for the transferrin receptor ( TfR ) , whose half life can be manipulated in culture by changing the availability of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We evaluated flow cytometric ( FCM ) analysis of transferrin receptor ( TFR ) expression as a marker for the malignant potential in transitional cell carcinoma ( TCC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
IRPs regulate iron metabolism by binding to iron responsive element ( s ) ( IREs ) in the 5 ' or 3 ' untranslated region of ferritin or transferrin receptor ( TfR ) mRNAs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We previously found that the proliferative response to transferrin and the expression of transferrin receptors ( TfR ) on the cell surface of various rat 13762NF mammary adenocarcinoma cell sublines correlated with their spontaneous metastatic capability . ^^^ To further assess the involvement of transferrin and TfR in metastasis , transferrin responsive cells were selected from the poorly metastatic , low transfferin responsive 13762NF MTLn 2 subline . ^^^ The selection of cells with high levels of TfR and a higher proliferative response to transferrin results in sublines with greater potentials for spontaneous metastasis . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The purpose of the current study was to examine the effect of increased meat intake on hemoglobin concentration ( Hb ) , serum ferritin ( SF ) , and serum transferrin receptors ( TfR ) in late infancy . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Double labeling experiments after the internalization of both transferrin and surface labeled GLUT 4 show that GLUT 4 accumulates within peripheral compartments that exclude the transferrin receptor ( TfR ) at both 15 degrees and 37 degrees C . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Soluble transferrin receptor ( TfR ) and absolute reticulocyte count ( ARC ) were also assayed in order to evaluate erythropoietic activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this report , we demonstrate in cultured 293 cells overexpressing wild type or mutant HFE proteins that both the wild type and H63D HFE proteins form stable complexes with the transferrin receptor ( TfR ) . ^^^ Studies on cell associated transferrin at 37 degrees C suggest that the overexpressed wild type HFE protein decreases the affinity of the TfR for transferrin . ^^^ Furthermore , at 4 degrees C , the added soluble complex of HFE / beta2m inhibited binding of transferrin to HeLa cell TfR in a concentration dependent manner . ^^^ Scatchard plots of these data indicate that the added heterodimer substantially reduced the affinity of TfR for transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin ( Tf ) , a major transport protein for iron in the blood and an essential growth factor in some tissues , acts via specific transferrin receptor ( TfR ) . ^^^ We studied the cellular distribution of Tf and TfR gene expression in 50 human nontumorous autopsy pituitaries and 42 surgically removed pituitary adenomas . ^^^ Tf and TfR mRNA accumulation was correlated with Ki 67 proliferation marker . ^^^ In pituitaries with iron deposits , Tf and TfR were localized only in iron free cells . ^^^ Transferrin ( Tf ) , a major transport protein for iron in the blood and an essential growth factor in some tissues , acts via specific transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A similar analysis of the distribution of the transferrin receptor ( TfR ) , the paradigm for recycling plasma membrane receptors , revealed that the portions of the TfR at the cell surface in both the basal and insulin treated states were almost unchanged upon differentiation , and that insulin caused an increase of about 1 . 6 fold in the amount of TfR at the cell surface . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
They have a clearing function because of their enrichment with some proteins known to decrease or disappear from the cell surface during maturation , eg , acetylcholinesterase ( AChE ) and transferrin receptor ( TfR ) , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After treatment of K 562 cells with sodium butyrate , the expression of transferrin receptor ( TfR ) increased initially , followed by an increase in the levels of both total iron and Hb as well as the ALAS activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin ( Tf ) is required for proliferation of most cells , because cellular iron uptake is mainly mediated by binding of Tf to its specific cell surface receptors ( TfR ) . ^^^ Furthermore , alpha 1 AT almost completely prevented internalization of the Tf TfR complex . ^^^ Transferrin ( Tf ) is required for proliferation of most cells , because cellular iron uptake is mainly mediated by binding of Tf to its specific cell surface receptors ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To evaluate storage iron deficiency and iron deficient erythropoiesis we determined , in a cross sectional study of 95 patients mainly including end stage renal disease patients ( ESRD ) with ( 32 ) and without rh EPO therapy ( 55 ) , the following parameters : hemoglobin , mean corpuscular red cell volume , ferritin , transferrin saturation ( TS ) , zinc protoporphyrin ( ZPP ) and soluble transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE binds to transferrin receptor ( TfR ) and reduces its affinity for iron loaded transferrin , implicating HFE in iron metabolism . ^^^ TfR : HFE stoichiometry ( 2 : 1 ) differs from TfR : transferrin stoichiometry ( 2 : 2 ) , implying a different mode of binding for HFE and transferrin to TfR , consistent with our demonstration that HFE , transferrin , and TfR form a ternary complex . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We developed a simple method to conjugate biotinylated double stranded DNA to biotinylated Tf via streptavidin and demonstrated successful transduction of the conjugate into TfR positive human cancer cells . ^^^ Transferrin receptor ( TfR ) is widely distributed on actively proliferating cells and is therefore an appropriate target for in vivo gene delivery into those cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The soluble human transferrin receptor ( TfR ) found in blood is the result of a proteolytic cleavage occurring in the ectodomain of the receptor close to the transmembrane domain at Arg 100 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor ( TfR ) levels , suggesting that NTBI formation is a consequence of suspension of erythropoietic activity . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study , we compared the cellular uptake of 59Fe transferrin ( Tf ) and 59Fe pyridoxal isonicotinoyl hydrazone ( PIH ) to determine whether the decrease in iron uptake by R cells is caused by changes in Tf receptor ( TfR ) dependent or TfR independent iron uptake . ^^^ The uptake of 59Fe Tf but not 59Fe PIH could be blocked by an anti TfR monoclonal antibody . ^^^ Our study suggests that the decrease in Tf Fe uptake by R cells is caused by a combination of enhanced iron efflux from cells and decreased TfR mediated iron transport into cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum transferrin receptors ( TfR ) are a sensitive index of tissue iron availability , increasing progressively in response to functional iron deficiency . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In previous studies we have shown that the free radical inducer menadione rapidly and specifically downmodulates the membrane transferrin receptor ( TfR ) by blocking receptor recycling . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By measuring the rates of endocytosis for either the overexpressed receptor , or that of other endogenous receptors , we were able to show that the endocytosis of identical receptors could be saturated , but a complete lack of competition exists between the transferrin receptor ( TfR ) , the low density lipoprotein receptor , and the epidermal growth factor receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , endocytosed L 1 colocalizes with the transferrin receptor ( TfR ) , a marker for clathrin mediated internalization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) and ferritin , key proteins of cellular iron metabolism , are coordinately and divergently controlled by cytoplasmic proteins ( iron regulatory proteins , IRP 1 and IRP 2 ) that bind to conserved mRNA motifs called iron responsive elements ( IRE ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The recent association of HFE gene with transferrin receptor ( TfR ) in trophoblast cells opens new possibilities on its role in cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) expression is up regulated during T cell activation after the interaction of the T cell receptor with the antigen major histocompatibility complex and the expression of interleukin 2 ( IL 2 ) receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cellular iron homeostasis is regulated by iron regulatory proteins ( IRPs ) , which bind to iron responsive elements ( IRE ) of mRNAs for ferritin and transferrin receptor ( TfR ) modulating iron uptake and sequestration , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The cellular iron uptake is a precisely controlled process to fulfill the iron demand for the synthesis and functions of a variety of iron containing proteins , and one of the main molecules involved is the transferrin receptor ( TfR ) , which mediates the uptake process via the transferrin cycle . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Immunohistochemical localization of the murine transferrin receptor ( TfR ) on blood tissue barriers using a novel anti TfR monoclonal antibody . ^^^ A novel monoclonal antibody ( mAb ) , 8D3 ( IgG2a ) , that specifically recognizes the murine transferrin receptor ( TfR ) was produced by immunizing a Lewis rat with a polyoma middle T oncogene transformed endothelioma cell line . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Increased concentrations of C reactive protein ( CRP ) were found in 5 patients , alpha 1 acid glycoprotein ( AGP ) in 3 , alpha 1 antitrypsin ( AAT ) in 8 , ceruloplasmin ( CER ) in 2 , alpha 2 macroglobulin ( AMG ) in 14 and decreased haptoglobin ( HPT ) and transferrin ( TFR ) in 11 and 9 , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although indices of iron status were not suggestive of iron deficiency , plasma TfR was negatively associated with plasma ferritin , Tf saturation , and plasma iron , and positively associated with total iron binding capacity ( TIBC ) ( p < 0 . 0001 for all ) . ^^^ PURPOSE : The goal of this study was to determine if the postnatal changes in plasma transferrin receptor ( TfR ) levels in healthy infants were associated with changes in erythropoiesis or iron status . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The results suggested that Tf Fe transport across the membrane of this type of neuron , much like other mammalian cells , was mediated by Tf TfR endocytosis . ^^^ Dysfunction of Tf or TfR would possibly lead to iron irregulation in the brain and consequently cause damage to neuronal functions . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
OBJECTIVE : To assess the ability of a transferrin adriamycin conjugate ( Tf ADR ) to target transferrin receptor ( TfR ) positive cancer cells selectively and to overcome drug resistance in bladder cancer cell lines . ^^^ CONCLUSION : Tf ADR did not prevent toxicity to the TfR negative cells nor did it overcome the resistance of the ADR resistant cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We extended those studies to examine the expression of transferrin ( Tf ) and its receptor ( TfR ) in endocervical carcinogenesis and any relationship to the expression of lactoferrin , steroid receptors and the proliferative index . ^^^ In situ detection of mRNA for Tf and the TfR was also performed . ^^^ RESULTS : No differences in the relative staining intensity for Tf and TfR proteins were noted between normal and neoplastic glands . ^^^ Expression of Tf and TfR did not correlate with the expression of steroid receptors and lactoferrin or with the rate of proliferation . ^^^ The increased number of malignant endocervical glands expressing TfR may indicate a special requirement for Tf and the iron that it carries . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Immunofluorescence double labeling for GLUT 4 and transferrin receptor ( TfR ) shows that the small depots can be further subdivided into TfR positive and TfR negative elements . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In a study of transferrin receptor ( TFR ) polymorphism in different ethnic groups using PCR and restriction cleavage we found a new Hin6I polymorphism in intron 7 and confirmed a tentative BanI polymorphism in exon 4 reported by Evans and Kemp [ Gene 1997 ; 199 : 123 131 ] . ^^^ The new TFR polymorphisms and haplotypes may also be useful markers in studies of interactions with the transferrin and hemochromatosis genes , the genetic influence on body iron stores and disease associations . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Alpha 1 AT completely inhibited the binding of Tf to its receptor ( TfR ) on THP 1 human myelomonocytic cells and cultured human monocytes . ^^^ Furthermore , alpha 1 AT almost completely prevented internalization of the Tf TfR complex in a dose dependent manner . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : The transferrin receptor ( TfR ) regulates the cellular uptake of serum iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cell culture in vitro , ABC ELISA , RNA dot blot and atom absorption spectrum analysis were used to study biological effects of low concentration of iron citrate ( Fe cit ) on the expression of transferrin receptor ( TfR ) in healthy human peripheral lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
OBJECTIVE : To highlight differences in the quantification of transferrin receptor ( TfR ) concentration ( a reliable index of iron deficiency ) between three different assay methods . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study we examined the diagnostic accuracy of iron parameters including mean cellular volume ( MCV ) , serum iron , transferrin , total iron binding capacity ( TIBC ) and its saturation , zinc protoporphyrin ( ZPP ) , ferritin and serum transferrin receptor ( TfR ) for the assessment of iron status in a population of anaemic pregnant women in Malawi . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We undertook this study to evaluate a recently introduced ELISA kit for determining serum transferrin receptor ( TfR ) concentration ( TfR , Ramco Laboratories , Inc . ) , to produce reference values for healthy adults , and to compare the results with another commercially available reagent system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hemoglobin concentration , hematocrit value , serum ferritin , and serum transferrin receptor ( TfR ) concentrations were measured . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Placental transferrin receptor ( TfR ) protein expression is increased in diabetic pregnancies that are complicated by low fetal iron stores , suggesting regulation of placental iron transport by fetoplacental iron status . ^^^ IRP 1 activity and TfR Bmax for diferric transferrin were greater in the iron deficient group ( P < 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : The serum transferrin receptor ( TfR ) concentration in adults is suggested to provide a sensitive measure of iron depletion and together with the serum ferritin concentration to indicate the entire range of iron status , from iron deficiency to iron overload . ^^^ Mean corpuscular volume , blood hemoglobin , transferrin iron saturation , transferrin , and even age seemed to not have an influence on the TfR concentration and erythropoiesis was not a determinant of TfR concentration . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These data suggest that the FAC activated Fe uptake process predominates at physiologically relevant Tf concentrations above the saturation of the Tf receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In placenta , the HFE protein colocalizes with and forms a stable association with the transferrin receptor ( TfR ) , providing a link between the HFE protein and iron transport . ^^^ In the present study , we examined the relationship of the HFE protein to the TfR in enterocytes of the human duodenum and measured the uptake of transferrin bound iron and ionic iron by isolated crypt and villus enterocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We recently reported that HFE , the protein defective in HH , was physically associated with the transferrin receptor ( TfR ) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin bound iron from plasma by duodenal crypt cells , leading to up regulation of transporters for dietary iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
At the cell surface , HFE complexes with transferrin receptor ( TfR ) , increasing the dissociation constant of transferrin ( Tf ) for its receptor 10 fold ( Gross , C . ^^^ HFE does not remain at the cell surface , but traffics with TfR to Tf positive internal compartments ( Gross et al . , 1998 ) . ^^^ Using a HeLa cell line in which the expression of HFE is controlled by tetracycline , we show that the expression of HFE reduces 55Fe uptake from Tf by 33 % but does not affect the endocytic or exocytic rates of TfR cycling . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We analyzed the cDNA sequences of transferrin receptor ( TFR ) , which was recently shown to interact with HFE , in twenty one hereditary hemochromatosis patients including sixteen individuals who did not carry a Cys 282 > Tyr mutation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cellular iron uptake is facilitated by transferrin receptor ( TfR ) mediated endocytosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recent demonstration of an association between transferrin receptor ( TfR ) and HFE , a major histocompatibility complex class 1 like molecule that has been implicated to play a role in hereditary hemochromatosis , further strengthens the notion that HFE is involved in iron metabolism . ^^^ Moreover , we show that HFE binding reduces the number of functional transferrin binding sites and impairs TfR internalization , thus reducing the uptake of transferrin bound iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulates the stability of the mRNA encoding the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study we have evaluated iron status in blood donors using serum ferritin and transferrin receptor ( TfR ) concentrations . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE binds tightly to transferrin receptor ( TfR ) , the receptor that mediates uptake of iron loaded transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Inoculation with viable , but not inactivated , Coxiella burnetii resulted in the increased expression of transferrin receptors ( TfR ) in the murine macrophage like cell line J774A . 1 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The HFE wild type gene product complexes with the transferrin receptor ( TF ) and two different HFE mutations ( Cys282Tyr and His63Asp ) have been found to increase the affinity of TFR for TF and increase cellular iron uptake . ^^^ A number of genes are involved in iron metabolism , including the transferrin receptor ( TFR ) and haemochromatosis ( HFE ) genes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin ( Tf ) . ^^^ Transferrin receptor ( TfR ) plays a major role in cellular iron uptake through binding and internalizing a carrier protein transferrin ( Tf ) . ^^^ Taken together , TfR 2 alpha may be a second transferrin receptor that can mediate cellular iron transport . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recent reports have indicated that early steps of beta 2AR endocytosis may involve mechanisms different from those which regulate the internalization of constitutively recycling receptors , such as transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These results were compared to the expression of transferrin receptor ( TfR ) mRNA which also has IREs in its 3 ' UTR and is regulated by Fe and NO via the binding of iron regulatory proteins ( IRPs ) to its IREs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study investigated the effects of strenuous exercise on transferrin ( Tf ) receptor ( TfR ) expression and Tf bound iron ( Tf Fe ) uptake in erythroblasts of rat bone marrow . ^^^ Tf recycling time and TfR affinity were not different in exercised and control rats . ^^^ The findings demonstrated that the increased cellular Fe uptake in exercised rats was a consequence of the increased TfR expression rather than the changes in TfR affinity and Tf recycling time . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor ( TfR ) , which mediates cellular iron uptake , is regulated by hypoxia . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Results indicate that adipose cells possess at least two distinct cell surface recycling pathways for insulin like growth factor II / mannose 6 phosphate receptor ( MPR ) and transferrin receptor ( TfR ) : one which is mediated by glucose transporter isoform 4 ( Glut 4 ) vesicles and another that bypasses this compartment . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated whether the soluble transferrin receptor ( TfR ) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia , six patients with congenital dyserythropoietic anaemia type 2 ( CDA 2 ) and four patients with 10 linked congenital sideroblastic anaemia ( XLSA ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Stimulation of macrophages with interferon gamma ( IFN gamma ) and / or lipopolysaccharide ( LPS ) decreased Fe uptake from transferrin ( Tf ) , and there was a concomitant downregulation of TfR expression . ^^^ To elucidate the pathways by which nitric oxide ( NO ) influences macrophage iron metabolism , the uptake , release , and intracellular distribution of iron in the murine macrophage cell line J 774 has been investigated , together with transferrin receptor ( TfR ) expression and iron regulatory protein ( IRP 1 and IRP 2 ) activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated whether HIF 1 is involved in transcriptional activation of the transferrin receptor ( TfR ) , a membrane protein which mediates cellular iron uptake , in response to iron deprivation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) undergoes multiple rounds of clathrin mediated endocytosis and reemergence at the cell surface , importing iron loaded transferrin ( Tf ) and recycling apotransferrin after discharge of iron in the endosome . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
When iron in the intracellular transit pool is scarce , IRPs bind to iron responsive elements ( IREs ) in the 5 ' untranslated region of the ferritin mRNA and 3 ' untranslated region of the transferrin receptor ( TfR ) mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE binds to transferrin receptor ( TfR ) , the receptor used by cells to obtain iron in the form of diferric transferrin ( Fe Tf ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
DESIGN : In this self selected sample , haemoglobin , haematocrit , red cell indices , serum ferritin , serum iron , serum transferrin , and serum transferrin receptor ( TfR ) were measured . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : Transferrin receptor ( TfR ) expression follows the induction of interleukin 2 receptor ( IL 2R ) expression in a sequence that is necessary to initiate cell proliferation in quiescent T lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In mammalian systems , control of intracellular iron homeostasis is largely due to posttranscriptional regulation of binding by iron regulatory RNA binding proteins ( IRPs ) to iron responsive elements ( IREs ) within ferritin and transferrin receptor ( TfR ) mRNAs . the TfR transports iron into cells and the iron is subsequently stored within ferritin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Simultaneous interaction of IRPs with multiple IREs in the 3 ' UTR of transferrin receptor ( TfR ) mRNA selectively causes its stabilization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The lighter of the two peaks ( peak 2 ) was comprised of two overlapping peaks : peak 2b contained recycling endosomal markers such as the transferrin receptor ( TfR ) , cellubrevin , and Rab 4 , and peak 2a was enriched in TGN markers ( syntaxin 6 , the cation dependent mannose 6 phosphate receptor , sortilin , and sialyltransferase ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A BLAST search with the sequence of the solved AMP structure indicated that a similar domain could be found in prostate specific membrane antigen ( PSMA ) and the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Since transferrin receptor ( TfR ) appears on activated T cells following the interaction of the antigen major histocompatibility complex ( MHC ) with the T cell receptor ( TCR ) and the appearance of interleukin ( IL ) 2R , we therefore hypothesize that in vivo blockade of TfR prolongs allograft survival by altering the cellular mechanisms involved in graft rejection . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we describe the further engineering of restrictocin based chimaeric toxins , anti TFR ( scFv ) restrictocin and restrictocin anti TFR ( scFv ) , containing restrictocin and a single chain fragment variable ( scFv ) of a monoclonal antibody directed at the human transferrin receptor ( TFR ) , to enhance their cell killing activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE binds to the transferrin receptor ( TfR ) , a receptor by which cells acquire iron loaded transferrin . ^^^ The HFE TfR complex suggests a binding site for transferrin on TfR and sheds light upon the function of HFE in regulating iron homeostasis . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Immune function endpoints evaluated included cell viability , lymphocyte blastogenesis stimulated by T cell mitogen ( concanavalin A , Con A ) or B cell mitogens [ lipopolysaccharide ( LPS ) or LPS / dextran sulfate ] , intracellular Ca2+ concentration , interleukin 2 ( IL 2 ) production , and expression of receptors for transferrin ( TfR ) and IL 2 ( IL 2R ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The decrease of the surface transferrin receptor ( TfR ) was correlated with expression levels of the mutant protein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hepatic iron loading in HH is progressive despite down regulation of the classical transferrin receptor ( TfR ) . ^^^ Recently a human cDNA highly homologous to TfR was identified and reported to encode a protein ( TfR 2 ) that binds holotransferrin and mediates uptake of transferrin bound iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of MTf mRNA ( poly A+ ) was also examined in 50 human tissues and found to be markedly different to Tf mRNA or TfR mRNA . ^^^ In contrast to transferrin receptor ( TfR ) mRNA that increased after exposure to DFO and decreased after incubation with FAC , there was no change in MTf mRNA levels . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory proteins ( IRP 1 and IRP 2 ) control the synthesis of transferrin receptors ( TfR ) and ferritin by binding to iron responsive elements , which are located in the 3 ' untranslated region and the 5 ' untranslated region of their respective mRNAs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study was designed to evaluate the effects of dietary ID and iron excess on rat brain iron and the iron metabolism proteins , transferrin ( Tf ) , transferrin receptor ( TfR ) and ferritin . ^^^ These experiments demonstrated several new findings : 1 ) Early ID / SU ( PND 10 21 ) altered brain iron , TfR , Tf and ferritin concentration in many regions different from those observed in the later period ( PND 21 35 ) . 2 ) Two weeks of iron repletion were adequate for correcting the overall Fe concentration of the brain and of individual brain regions , although larger amounts of iron were necessary to fully normalize iron and its regulatory proteins . 3 ) Long term ID / SU resulted accordingly in the continued decrease or increase in brain iron concentration in some brain regions and not others . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously shown that this anti proliferative activity resides in a self aggregating complex in which eight proteins , namely integrins alpha ( 5 ) ( CD49e ) and alpha ( 5 ) ( CD 51 ) , dipeptidyl peptidase 4 ( DPP 4 , CD 26 ) , alpha actinin , transferrin receptor ( TfR , CD 71 ) , transferrin , placental alkaline phosphatase ( PLAP ) and monoamine oxidase A ( MAO A ) were identified . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Retrospective chart review and assay of frozen antenatal serum ( for serum erythropoietin concentration [ serum EPO ] ) , transferrin receptor protein [ TfR ] , ferritin , folate and B 12 ) were performed . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The synergistic use of antisense oligonucleotides ( ASOs ) towards the bcr abl and the transferrin receptor ( TfR ) mRNA was studied in a chronic myeloid leukemia ( CML ) cell line , aiming to improve the efficiency of individual ASO treatment . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hemoglobin synthesis consumes most of the iron that is taken up by cells from plasma transferrin , and this process requires very high expression of transferrin receptors ( TfR ) at the membranes of erythroid cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Vesicles containing a dendritic protein , transferrin receptor ( TfR ) , were preferentially transported into dendrites and excluded from axons . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor ( TfR ) transferrin cycle and the activity of the divalent metal transporter ( DMT 1 ) , although DMT 1 can not be detected morphologically in crypt cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
One hypothesis suggests that an interaction between the transferrin receptor ( TfR ) and the haemochromatosis protein ( HFE ) regulates the level of iron loading in crypt cells . ^^^ We investigated TfR function and distribution by measuring iron uptake from plasma transferrin and by immunohistochemistry . ^^^ The uptake of transferrin bound iron ( Tf Fe 2 ) into mucosal cells subsequently separated along the crypt villus axis was compared to the presence of TfR , determined by immunohistochemistry using frozen and wax sections . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We used multivariate regression to analyze cross sectional data from a community based sample of rural Zanzibari children who were not ill ( n = 490 ; 4 71 mo of age ) in whom we assessed hemoglobin , serum ferritin ( SF ) , erythrocyte protoporphyrin ( EP ) , serum transferrin receptor ( TfR ) , recent fever , malaria parasitemia and helminth fecal egg counts . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Its action upon the transferrin receptor ( TfR ) and upon the expression of brain transferrin , as well as its effect on the proliferation and differentiation of oligodendroglial cells ( OLGc ) was one of the main objectives of our investigation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , we investigated the roles of TfR in transferrin bound iron ( Tf Fe ) as well as transferrin free iron ( Fe 2 ) uptake by the cells . ^^^ These findings suggested that Tf Fe transport across the membrane of astrocytes is mediated by Tf TfR endocytosis . ^^^ Previously we had demonstrated the presence of transferrin receptor ( TfR ) on the plasma membrane of cultured rat cortical astrocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The iron overload disease hereditary haemochromatosis ( HH ) occurs in about 1 in 300 Caucasians ; the protein mutated in this disorder is termed HFE . ( 1 ) HFE is homologous to major histocompatibility complex ( MHC ) class 1 proteins , but unlike MHC class 1 molecules , HFE does not present peptides to T cells . ( 2 ) The transferrin receptor ( TfR ) is a ligand for HFE , and the crystal structure of the HFE TfR complex has been determined . ( 3 ) The many interesting features of this structure illustrate the diverse roles of the MHC fold in nature and clarify how HFE affects TfR function . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Functional as well as molecular studies of the HFE protein have indicated that the molecule is involved in iron metabolism and that the HFE gene variations observed among HH patients affect its interaction with the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Sorting signals from the transferrin receptor ( TFR ) , targeted a chimeric OVA fusion protein to early endosomes and led to the generation of 8 of 12 presented peptides . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Previous studies have shown that an unidentified kinase substrate is required for endocytosis of the epidermal growth factor receptor ( EGFR ) , the prototypical ligand inducible receptor , but not of the transferrin receptor ( TfR ) , the prototypical constitutively internalized receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum transferrin receptor ( TfR ) has been reported to be a reliable tool for the diagnosis of iron deficiency in adults . ^^^ A total of 63 consecutive patients with IBD , aged 9 to 22 years ( median 15 years ) , were tested for serum haemoglobin level , mean corpuscular volume ( MCV ) , and serum iron , transferrin , ferritin and serum TfR levels . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recent investigations indicate that this cumbersome procedure can be avoided by measuring an important new iron related measurement , the serum transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Soluble transferrin receptors ( TfR ) may be an exception but have not been examined longitudinally during the major metabolic and inflammatory changes which occur during clinical malaria . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In order to rationalize the physicochemical properties of human serum transferrin ( STf ) and the STf receptor ( TfR ) recognition process , we have tried to predict the 3D structures of apo and iron loaded STf using a homology modeling technique to study the changes in the structural characteristics that take place upon the uptake of iron by STf in solution . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We determined the efficacy of HB 21 ( Fv ) PE 40 , a single chain immunotoxin made by fusing the variable regions of a monoclonal antibody directed at the human transferrin receptor ( TfR ) with a truncated mutant of Pseudomonas exotoxin ( PE ) , against metastatic human colon carcinoma KM12L4 cells growing in the liver or subcutis of nude mice . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To follow the transport of human syntaxin ( Syn ) 3 to the apical surface of intestinal cells , we produced and expressed in Caco 2 cells a chimera made of the entire Syn 3 coding sequence and the extracellular domain of the human transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) interacts with two proteins important for iron metabolism , transferrin ( Tf ) and HFE , the protein mutated in hereditary hemochromatosis . ^^^ A second receptor for Tf , TfR 2 , was recently identified and found to be functional for iron uptake in transfected cells ( Kawabata , H . , Germain , R . ^^^ To investigate the relationship between TfR , TfR 2 , Tf , and HFE , we performed a series of binding experiments using soluble forms of these proteins . ^^^ The affinity of TfR 2 for iron loaded Tf was determined to be 27 nm , 25 fold lower than the affinity of TfR for Tf . ^^^ These results imply that HFE regulates Tf mediated iron uptake only from the classical TfR and that TfR 2 does not compete for HFE binding in cells expressing both forms of TfR . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Epithelial expression of Ki 67 , FAS , and transferrin receptor ( TFR ) was detected by immunohistochemistry , and apoptosis by TUNEL technique ( percentage of positive enterocytes ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We assessed nonfasting plasma concentrations of folic acid , vitamin B 12 , vitamin B 6 ( as pyridoxal 5 ' phosphate ) , hemoglobin ( Hb ) , ferritin and transferrin receptor ( TfR ) in 563 nonpregnant textile workers aged 21 34 y from Anqing , China . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Treatment with LPS resulted in an increase in 59Fe uptake from 59Fe nitrilotriacetic acid , while transferrin receptor ( TfR ) mRNA levels and 59Fe uptake from 59Fe Tf were decreased . ^^^ These results are of interest as the TfR and Nramp 2 are thought to act together during Fe uptake from Tf . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
While all tested cytokines individually and in combination inhibited the expression of the transferrin receptor ( TfR ) on macrophages , IFN gamma alone and in combination with other cytokines most strongly repressed the TfR expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : The serum transferrin receptor ( TfR ) and the ratio of TfR to serum ferritin ( TfR : SF ) have been shown to be useful as early indicators of iron deficiency . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have investigated the expression of transferrin receptor ( TfR ) iron regulatory protein 1 ( IRP 1 ) and iron regulatory protein 2 ( IRP 2 ) in liquid suspension culture of purified hematopoietic progenitor cells ( HPCs ) induced by a growth factor stimulus to proliferation and unilineage differentiation / maturation through the erythroid , granulocytic , monocytic and megakaryocytic lineages . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Whereas transferrin receptor ( TfR ) is responsible for iron uptake from maternal serum by the syncytiotrophoblast , the proteins responsible for intracytoplasmic transport and for delivery to the fetal serum remain unknown . ^^^ We postulate that the syncytiotrophoblast takes up diferric transferrin from serum via TfR , subsequently incorporating the transferrin : TfR complex via endosomes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The wild type HH ( HFE ) protein complexes with the transferrin receptor ( TFR ) , and two HFE mutations ( Cys282Tyr and His63Asp ) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Overexpression of both Rab 11 wild type ( Rab11wt ) and mutants altered the localization of the transferrrin receptor ( TfR ) , internalized Tf , the STxB , and TGN 38 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Finger stick blood samples ( 500 microL ) were collected for measurement of plasma ferritin , transferrin receptor ( TfR ) , and hemoglobin ( Hb ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) of reticulocytes is released in vesicular form ( exosomes ) during their maturation to erythrocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have evaluated a newly introduced immunoturbidimetric transferrin receptor assay ( IdeA TfR IT , Orion Diagnostica , Finland ) in healthy subjects and in a study population consisting of patients with rheumatoid arthritis and juvenile chronic arthritis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition , transferrin receptor ( TfR ) enriched vesicles were observed close to Cpn vacuoles , potentially indicating a specific translocation of these organelles through the cytoplasm to the vicinity of the vacuole . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Reticulocyte transferrin receptor ( TfR ) expression and contribution to soluble TfR levels . ^^^ BACKGROUND AND OBJECTIVES : Transferrin receptor ( TfR ) expression in erythroid cells is regulated by a number of factors , including iron status and erythropoietin ( Epo ) stimulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The wild type HFE associates and co traffics with the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cellular iron uptake and storage are coordinately controlled by binding of iron regulatory proteins ( IRP ) , IRP 1 and IRP 2 , to iron responsive elements ( IREs ) within the mRNAs encoding transferrin receptor ( TfR ) and ferritin . ^^^ This is associated with a profound increase in the cell surface expression of TfR , enhanced binding to fluorescein tagged transferrin , and stimulation of transferrin mediated iron uptake into cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Our results reveal a significant increase in the expression of transferrin receptor ( TfR ) mRNAs and a corresponding increase in cellular 59Fe net uptake by PC 12 cells , but not astrocytes , following Mn exposure . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The subsequent changes in expression pattern of VEGF and transferrin receptor ( TfR ) , a target gene of hypoxia inducible factor 1alpha ( HIF 1alpha ) , were examined by semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) and enzyme linked immunosorbent assay . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) number was 2 to 3 fold greater in WT cells than in C282Y cells , while TfR affinity for transferrin ( Tf ) was slightly lower in C282Y cells . ^^^ When considered relative to cell surface TfR number , however , iron uptake and Tf internalization were actually greater in C282Y cells . ^^^ Transferrin receptor ( TfR ) number was 2 to 3 fold greater in WT cells than in C282Y cells , while TfR affinity for transferrin ( Tf ) was slightly lower in C282Y cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Stimulator of Fe Transport ( SFT ) and transferrin receptor ( TfR ) are proteins involved in iron transport . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We demonstrate here that modification of OVA cDNA as transferrin receptor ( TfR ) or invariant chain ( 2 ) fusions effectively generate MHC class 2 specific immune responses in addition to MHC class 1 responses . ^^^ TfR OVA contains the membrane anchoring region of transferrin receptor and represents a membrane bound form of OVA for access to the MHC class 2 compartment . 2 OVA fusions directly target the MHC class 2 processing pathway . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Temporal induction of the major histocompatibility ( MHC ) class 2 molecules , E selectin ( CD62E ) , vascular cell adhesion molecule ( VACM 1 ) ( CD 106 ) as well as altered expression of constitutively expressed intercellular adhesion molecule 1 ( ICAM 1 ) ( CD 54 ) , the glucose transporter protein ( glut 1 ) , the transferrin receptor ( tfR ) ( CD 71 ) , and MHC class 1 molecules was examined at various times following impact . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
For each subject we examined intragenic HFE haplotypes and transferrin receptor ( TfR ) gene polymorphisms and searched for the Y250X mutation on the TFR 2 gene . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) is a N and O glycosylated transmembrane protein mediating the cellular iron uptake by binding and internalization of diferric transferrin . ^^^ In this study , rate constants and dissociation constants of 125I ferri transferrin binding to the human TfR were examined dependent on receptor glycan composition , pH , bivalent cations , and temperature . ^^^ We found that transferrin binding was clearly dependent on a receptor pretreatment with buffers of various pH in that most of the TfR molecules irreversibly lost transferrin binding activity below pH 6 . 5 . ^^^ Treatment with EDTA also caused an irreversible loss of transferrin binding activity , indicating that the functionally active conformation of the mature TfR depends on bivalent cations . ^^^ In contrast to the parameters described above , all desialylated and N deglycosylated TfR variants had exactly the same transferrin binding properties as the native TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
PURPOSE : To investigate the effect of tyrphostin 8 ( T 8 ) , a GTPase inhibitor , on transferrin receptor ( TfR ) mediated transcytosis of insulin transferrin ( In Tf ) conjugate in cultured enterocyte like Caco 2 cells and on gastrointestinal ( GI ) absorption of In Tf in streptozotocin ( STZ ) induced diabetic rats . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The cellular mechanism responsible for the polarization of the dendritic marker protein transferrin receptor ( TfR ) in mature cells centers on directed transport to the dendritic domain . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
As a model we have chosen doxorubicin conjugates targeted to the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The fact that TfR ODna specifically decreases cell viability and proliferation , and reduces TfR mRNA and protein expression in human breast carcinoma cells without affecting normal breast cells , suggests that the antisense oligonucleotide to the transferrin receptor may be a novel therapeutic approach in breast cancer . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the changes of transferrin receptor ( TfR ) mRNA and ferrochelatase mRNA levels under different iron status of DMSO induced or non induced MEL cells . ^^^ TfR mRNA and ferrochelatase mRNA were assayed by Northern blot after adding transferrin , deferrioxamine , anti TfR monoclonal antibody ( McAb ) or Epo , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The gain ( increase ) from receiving fortified diet during the study period was at most [ upper limit for 95 % confidence interval ( CI ) ] 2 . 6 g l ( 1 ) in blood haemoglobin , 1 . 9 fl in mean corpuscular volume , 2 . 7 micromol in serum iron and 4 . 5 % in transferrin iron saturation , and the gain ( decrease ) was at most ( lower limit for 95 % CI ) 0 . 29g l ( 1 ) in serum transferrin and 0 . 9mg l ( 1 ) in serum transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Northern blotting was used to examine the expression of mRNAs encoding transferrin receptor ( TfR ) , which is regulated by cytosolic aconitase . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We compared the ability of soluble serum transferrin receptor ( TfR ) concentration , quantified using the R & D Systems ( Minneapolis , MN ) enzyme linked immunosorbent TfR assay , with other , more traditional indicators of iron status ( total iron binding capacity [ TIBC ] , mean corpuscular volume [ MCV ] , percent transferrin saturation [ % TS ] , RBC distribution width [ RDW ] , and serum iron concentration [ SIC ] ) for discriminating between patients with iron deficiency anemia ( IDA ) or anemia of chronic disease ( ACD ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
There is evidence linking HFE with reduced iron uptake by the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
At low concentrations of antagonists ( approximately 1 microm ) , Tf and TfR accumulated in centrally located recycling endosomes , whereas at higher concentrations ( approximately 10 microm ) , Tf TfR accumulated in peripheral sorting endosomes . ^^^ These results are consistent with the conclusion that endosome membrane tubules are formed by the action of a cytoplasmic PLA ( 2 ) and that PLA ( 2 ) dependent tubules are involved in intracellular recycling of Tf and TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
TfR binding sites were positively correlated with SF and CF , and negatively with Tf . . ^^^ The relationship between the expression of transferrin receptors ( TfR ) on leukemia cells and the cell proliferation and iron metabolism status in childhood acute leukemias ] . ^^^ OBJECTIVE : To explore the relationship between transferrin receptor ( TfR ) expression and cell proliferation capacity and iron metabolism status . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptors ( TfR ) in K 562 cells are able to bind Tf , when carrying either iron ( Fe ) or Al , with similar affinity . ^^^ Transferrin receptors ( TfR ) in K 562 cells are able to bind Tf , when carrying either iron ( Fe ) or Al , with similar affinity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR , CD 71 ) is an integral membrane glycoprotein that mediates cellular uptake of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Based on recent structural , biochemical , and cell biological studies , transferrin receptor ( TfR ) is a ligand for HFE . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To assess efficacy of the 3 treatments , serial blood samples were analyzed for hemoglobin ( Hb ) , hematocrit ( Hct ) , reticulocyte count , red blood cell indices and plasma levels of transferrin , transferrin receptor ( TfR ) , ferritin , and iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined peripheral blood lymphocyte antigens / cytokine production using four colour flow cytometry and serum transferrin receptor ( TfR ) levels , an inverse measure of iron status unaffected by acute illness or infection , with an enzyme linked immunosorbent assay . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Studies by immunoblotting using membrane fractions from peripheral blood or spleen from normal mice where reticulocytosis was induced by erythropoietin ( EPO ) or phenylhydrazine ( PHZ ) treatment suggest that DMT 1 is coexpressed with transferrin receptor ( TfR ) in erythroid cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An average cellugyrin positive vesicle carries not more than one molecule of either Glut 4 , insulin responsive aminopeptidase ( IRAP ) , or transferrin receptor ( TfR ) , whereas cellugyrin negative vesicles contain five to six molecules of Glut 4 , more than 10 molecules of IRAP , and still one molecule of TfR per vesicle . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) binds two proteins critical for iron metabolism : transferrin ( Tf ) and HFE , the protein mutated in hereditary hemochromatosis . ^^^ Previous results demonstrated that Tf and HFE compete for binding to TfR , suggesting that Tf and HFE bind to the same or an overlapping site on TfR . ^^^ TfR is a homodimer that binds one Tf per polypeptide chain ( 2 : 2 , TfR / Tf stoichiometry ) , whereas both 2 : 1 and 2 : 2 TfR / HFE stoichiometries have been observed . ^^^ Both techniques indicate that a 2 : 2 TfR / HFE complex can form at submicromolar concentrations in solution , consistent with the hypothesis that HFE competes for Tf binding to TfR by blocking the Tf binding site rather than by exerting an allosteric effect . ^^^ To determine whether the Tf and HFE binding sites on TfR overlap , residues at the HFE binding site on TfR were identified from the 2 . 8 A resolution HFE TfR co crystal structure , then mutated and tested for their effects on HFE and Tf binding . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The value of soluble transferrin receptor ( sTfR ) detected in serum is closely related to erythroid TfR turnover rate . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of the transferrin receptor ( TfR ) is controlled essentially by post transcriptional regulation , which is mediated by the interaction between iron regulatory proteins ( IRPs ) and iron responsive elements ( IREs ) located in the 3 ' untranslated region ( UTR ) of TfR mRNA . ^^^ In contrast , expression of the transferrin receptor 2 ( TfR 2 ) , which was also cloned in the same vector and stably expressed in the TRVb CHO cells , was not regulated by iron chelation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : The in vitro cytotoxicity against glioma cells of transferrin ( Tf ) based targeted toxins was compared with that of alpha transferrin receptor ( TfR ) immunotoxin . ^^^ Tf saporin and alpha TfR saporin immunotoxin had similar efficacy , even in the more quantitative clonogenic assay ( 4 5 log kill with 1 10 10 ( 9 ) m ) using the myeloma cell line RPMI 8226 and glioma cell line U 251 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Erythroblast surface TfR expression and iron uptake was assessed in vitro using ( 125 ) 1 transferrin ( Tf ) and ( 59 ) Fe Tf , respectively . ^^^ The efficiency of erythroblast surface TfR function for Tf iron uptake was determined by relating total iron uptake at 4 hours to surface TfR number . ^^^ Erythroblasts obtained from patients with simple IDA showed a significant increase in surface TfR expression ( P = 0 . 0003 ) and Tf iron uptake ( P = 0 . 001 ) . ^^^ This increase was not associated with an increase in surface TfR expression ( P = 0 . 5 ) , but was seen to occur as a result of a significant increase in the efficiency of surface TfR for Tf iron uptake ( P = 0 . 027 ) . ^^^ This additional erythroblast response to absent RE iron stores led to a highly significant difference in serum sTfR values between RA IDA and RA ACD ( 40 . 2 + / 14 . 0 versus 23 . 9 + / 5 . 3 nmoles / liter ; P = 0 . 001 ) CONCLUSIONS : An increase in erythroblast surface TfR efficiency for Tf iron uptake compensates for the low plasma iron levels associated with anemia in RA and helps to maintain RA erythroblast iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using an enzyme linked assay for receptor ligand interactions based on the published direct calibration ELISA technique , we determined an equilibrium constant of Kd=0 . 22 nM for the binding of unmodified human Tf to surface immobilized human TfR . ^^^ The human transferrin receptor ( TfR ) and its ligand , the serum iron carrier transferrin , serve as a model system for endocytic receptors . ^^^ In the present study , we determined the equilibrium binding constant of purified human TfR and transferrin . ^^^ The results were compared to those obtained with either iodinated TfR or transferrin . ^^^ In contrast , covalent labeling of either TfR or transferrin with 125I reduced the affinity 3 5 fold to Kd=0 . 66 nM and Kd=1 . 01 nM , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , transferrin receptor ( TfR ) was shown to be overexpressed in the same HCC samples . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
K 562 cells release exosomes with similar characteristics to reticulocyte exosomes , in particular the transferrin receptor ( TfR ) is found associated with the vesicles . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The anemic subjects were classified on the basis of plasma transferrin receptor ( TfR ) concentration into an iron deficiency anemia group ( TfR concentration 2 . 4mgL1 , n=14 ) and an adequate iron stores group ( TfR concentration < 2 . 4mgL1 , n=20 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In primary chicken erythroblasts ( stem cell factor [ SCF ] erythroblasts ) , transferrin receptor ( TfR ) messenger RNA ( mRNA ) and protein were hyperexpressed as compared to nonerythroid chicken cell types . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of the present study was to address the regulation of transferrin receptor ( TfR ) , which mediates cellular iron uptake , during I / R . ^^^ The increased expression of TfR at the cell surface resulted in increased uptake of transferrin bound iron into surviving liver slices ; however , iron was not incorporated into ferritin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : The PNA is biotinylated , which allows for rapid capture by a conjugate of streptavidin and the rat 8D3 monoclonal antibody ( mAb ) to the mouse transferrin receptor ( TfR ) , and contains a tyrosine residue , which enables radiolabeling with 125I . ^^^ This form of the PNA is able to access endogenous transferrin transport pathways at both the blood brain barrier and the brain cell membrane and undergoes both import from the blood to the brain and export from the brain to the blood through the TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the efficacy of two biomarkers , transferrin receptor ( TfR ) and epidermal growth factor receptor ( EGFR ) , for the early detection of cervical dysplasia and to explore the relationship of E 5 , one of three viral oncogenes expressed by the human papillomavirus ( HPV ) , to TfR and EGFR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we provide evidence that both RIPs can be used for the construction of conjugates directed to a target such as the transferrin receptor ( TfR ) , which is over expressed in cancer cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here , we characterized the post synthetic and post endocytic sorting of the fast recycling low density lipoprotein receptor ( LDLR ) and transferrin receptor ( TfR ) in LLC PK 1 cells , which lack mu 1B and mis sort both receptors to the apical surface . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory proteins ( IRPs ) 1 and 2 are cytosolic proteins that regulate the stability of mRNA for the two major cellular iron transporters , transferrin receptor ( TfR ) and divalent metal transporter 1 ( DMT 1 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Studies showed that anti rat TfR IgG 3 Av exists as a dimer , suggesting that cross linking of the surface transferrin receptor may be responsible for the cytotoxic activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) is a transmembrane protein that mediates cellular uptake of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The presence of 3 MA during in vitro maturation of reticulocytes induced a decrease in exosome secretion , as measured by the amount of transferrin receptor ( TfR ) released in the extracellular medium . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is a glycoprotein which mediates the entry of ferric transferrin from the extracellular compartment into the cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , to elucidate the mechanism of hepatic iron overload in ALD , we immunohistochemically investigated the expression of transferrin receptor ( TfR ) , which mainly acts for cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor 3 ' untranslated region ( TfR 3 ' UTR ) mRNA is unique in having five IREs , linked by AU rich elements . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : An expression plasmid encoding bacterial beta galactosidase , under the influence of either the simian virus ( SV ) 40 promoter or the glial fibrillary acidic protein ( GFAP ) gene promoter , was packaged in the interior of 85 nm pegylated immunoliposomes ( PIL ) targeted to transferrin receptor ( TfR ) rich structures with the rat 8D3 monoclonal antibody ( mAb ) to the mouse TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Blood samples at 4 , 6 , and 9 months of age were analyzed for hemoglobin ( Hb ) , mean cell volume ( MCV ) , zinc protoporphyrin ( ZPP ) , plasma ferritin , and transferrin receptors ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Addition to cultures of an antibody against transferrin receptor ( TfR ) , protein kinase inhibitors , or a cyclic AMP ( cAMP ) analogue showed that a functionally intact TfR was necessary , and that tyrosine kinase , protein kinase C and A , as well as calcium calmodulin dependent kinase ( Ca CaMK ) activities appeared to mediate aTf actions upon the expression of the above mentioned genes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The ectodomain of the human transferrin receptor ( TfR ) is released as soluble TfR into the blood by cleavage within a stalk . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
It does this via iron regulatory proteins ( IRPs ) which bind reversibly to the iron responsive elements ( IREs ) on the mRNA of transferrin receptor ( TfR ) , erythroid 5 aminolaevulinic acid synthase ( ALA S 2 ) and ferritin . ^^^ Erythroblasts in ACD seem doubly equipped to protect their iron supply with their ability to increase the efficiency of transferrin iron uptake as well as to activate the IRP / IRE system to increase surface TfR production . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the liver , CP ( / ) mice showed no increase of gene expression for DMT 1 and transferrin receptors ( TFR and TFR 2 ) , indicating that none of the known pathways of iron uptake is activated in hepatocytes of CP ( / ) mice . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We used a quantitative enzyme immuno assay for the detection of MIP 1alpha as well as for the measurement of the acute phase protein serum amyloid A ( SAA ) , the erythropoiesis inducer erythropoietin ( EPO ) and the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin ( Tf ) bound to the transferrin receptor ( TfR ) . ^^^ TfR 2 is capable of Tf mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis unrelated to the hereditary hemochromatosis protein , HFE . ^^^ Recently , a second transferrin receptor , transferrin receptor 2 ( TfR 2 ) , has been identified and shown to play a critical role in iron metabolism . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recently , 2 different types of transferrin receptors have been recognized : transferrin receptor ( TfR or transferrin receptor 1 ) and transferrin receptor 2 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
High expression of transferrin receptor ( TfR ) on the membrane of erythroid cells accounts for the high level of iron required to sustain heme synthesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE accumulates in transferrin containing endosomes , and its overexpression in human cell lines correlates with decreased transferrin receptor ( TFR ) mediated iron uptake and decreased intracellular iron pools . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Our aim was to establish appropriate cut off values for hemoglobin ( Hb ) , plasma ferritin , erythrocyte mean cell volume ( MCV ) , zinc protoporphyrin ( ZPP ) and soluble transferrin receptors ( TfR ) in infancy . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron deficiency is the most common micronutrient deficiency worldwide , and transferrin receptor ( TfR ) level has been identified as an important measure of iron status that is not confounded by inflammation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mRNAs encoding transferrin receptor ( TfR ) were identified by Northern blot analyses . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have recently described a cationic immunoliposome system directed by a lipid tagged , single chain antibody Fv fragment ( scFv ) against the human transferrin receptor ( TfR ) that shows promising efficacy for systemic p 53 tumor suppressor gene therapy in a human breast cancer metastasis model . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) of Trypanosoma brucei is a heterodimer attached to the surface membrane by a glycosylphosphatidylinositol ( GPI ) anchor . ^^^ Similar surface accumulation was observed when the TfR levels were physiologically upregulated threefold when trypanosomes were starved for transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated transferrin receptor ( TfR ) dependent and independent iron transport mechanisms in cytokine stimulated human monocytic cell lines THP 1 and U 937 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , we report that H2O2 dependent intracellular oxidation of DCFH to a green fluorescent product , 2 ' , 7 ' dichlorofluorescein ( DCF ) , required the uptake of extracellular iron transported through a transferrin receptor ( TfR ) in endothelial cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
MPP ( + ) treatment enhanced the cell surface transferrin receptor ( TfR ) expression , suggesting a role for TfR induced iron uptake in MPP ( + ) toxicity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Canine and feline viruses both use the feline transferrin receptor ( TfR ) to infect feline cells , and here we show that CPV infects canine cells through its ability to specifically bind the canine TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory proteins ( IRP 1 and IRP 2 ) control the synthesis of transferrin receptors ( TfR ) and ferritin by binding to iron responsive elements ( IREs ) that are located in the 3 ' untranslated region ( UTR ) and the 5 ' UTR of their respective mRNAs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HD 3 differentiation is characterized by increased transferrin receptor ( TFR ) expression and increased hemoglobin ( Hb ) synthesis , a marker for the erythrocyte . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory proteins ( IRP 1 and IRP 2 ) control the synthesis of transferrin receptors ( TfR ) and ferritin by binding to iron responsive elements ( IREs ) which are located in the 3 ' untranslated region ( UTR ) and the 5 ' UTR of their respective mRNAs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The TH expression plasmid is encapsulated inside an 85 nm PEGylated immunoliposome ( PIL ) that is targeted with either the OX 26 murine monoclonal antibody ( MAb ) to the rat transferrin receptor ( TfR ) or with the mouse IgG2a isotype control antibody . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TfR ) is proteolytically cleaved at R 100 within the juxtamembrane stalk and to a lesser extent at an alternative site . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron transport in the plasma is carried out by transferrin , which donates iron to cells through its interaction with a specific membrane receptor , the transferrin receptor ( TfR ) . ^^^ Soluble TfR is a truncated monomer of tissue receptor , lacking its first 100 amino acids , which circulates in the form of a complex of transferrin and its receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The mechanism of the regulation of transferrin ( Tf ) and transferrin receptor ( TfR ) levels in rat brain by dietary iron status is not fully elucidated . ^^^ We examined Tf and TfR protein and mRNA contents in various brain regions affected by dietary iron deficiency , and analyzed the relationships between protein and mRNA contents in brains of control vs . iron deficient rats . ^^^ In a region specific fashion , iron deficient diet decreased significantly brain iron concentration by 22 63 % , and increased Tf level by 22 130 % and TfR level by 74 % in thalamus and 40 % in cortex . ^^^ The corpus callosum , white matter of the cerebellum and lateral ventricles expressed highest levels of Tf mRNA , whereas TfR mRNA levels was lowest in these regions , but highest in cortex , hippocampus , and the gray matter of the cerebellum . ^^^ This capacity may be associated with increased iron Tf uptake from plasma , stabilization of TfR mRNA , or increased Tf mRNA translation efficiency in specific cell types within the brain . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Soluble transferrin receptor ( TfR ) concentration rapidly decreased from 2 , 725 microgram / L to 1 , 548 during the 12 h postoperative period . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To gain insight into molecular mechanism , IANBD labeled transferrin ( Tf ) and microscopic fluorescence imaging were used to observe the endocytosis and recycling of the Tf TfR complex in single live cells . ^^^ Fluorescence quenching was used to study the kinetics of the transferrin receptor ( TfR ) mediated iron uptake in the calcein loaded K 562 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The membrane proteins that mediate iron transport [ transferrin receptor ( TfR ) and divalent metal transporter 1 ( DMT 1 ) ] and the iron regulatory proteins ( IRP 1 and IRP 2 ) that stabilize their mRNAs undergo regional developmental changes in the iron sufficient rat brain between postnatal day ( P ) 5 and 15 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Clara cell protein ( CC 16 ) and transferrin receptor ( TfR ) have been reported as possible biological markers for major depression and schizophrenia . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Overexpression of some oncogenes such as HER 2 ( c erbB 2 , Neu ) , bcl 2 / bcl xL , protein kinase A ( PKA ) , and transferrin receptor gene ( TfR gene ) , etc significantly affect the prognosis of breast cancer . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The results of this study show that the phagosomes containing live M . a . ptb had increased levels of an early marker ( transferrin receptor [ TFR ] ) and decreased levels of a late maturation marker ( lysosome associated membrane protein one [ Lamp 1 ] ) , relative to those containing killed M . a . ptb , M . smegmatis , and zymosan A . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , recycling blockade with bafilomycin A 1 significantly decreased transferrin receptor ( TfR ) surface expression but had no effect on DAT surface levels , suggesting that DAT and TfR traffic via distinct endosomal mechanisms . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , we constructed two CD 81 chimeras by linking the cytoplasmic domains of recycling surface receptors , low density lipoprotein receptor ( LDLR ) , and transferrin receptor ( TfR ) , respectively , to CD 81 and compared their internalization properties to wild type CD 81 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To explore this , the effects of 24 h in vitro manganese exposure ( 1 , 10 , 50 , and 200 microM Mn ) on : ( 1 ) total intracellular and labile iron concentrations ; ( 2 ) the cellular abundance of transferrin receptor ( TfR ) , H and L ferritin , and mitochondrial aconitase proteins ; and ( 3 ) IRP binding to a [ 32P ] ( ) labeled mRNA sequence of L ferritin were evaluated in undifferentiated PC 12 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have analyzed the intracellular behavior of the human transferrin receptor ( TfR ) in Saccharomyces cerevisiae . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of Tf receptor ( TfR ) in the cerebral endothelium increased with a peak at 1 day after the reperfusion and returned to the control level by 6 days . ^^^ The Tf PEG fluorescence was marginally detectable in sham control brain , but remarkably increased with a peak at 2 days , showing about 70 % of TfR positive vascular endothelium double labeled with Tf PEG . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We validated this procedure with two previously characterized cell surface receptors , glutamate receptor subunit A ( GluR A ) and the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , iron status had no significant effect on DMT 1 ( IRE ) and DMT 1 ( non IRE ) mRNAs expression in the heart , although it can significantly influence heart transferrin receptor ( TfR ) mRNA expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : ( 67 ) Ga and ( 59 ) Fe uptakes were measured in HeLa cells transfected with a FLAG tagged wild type HFE ( fHFE ) gene under control of a tetracycline repressible promoter . fHFE and TfR protein levels were measured by Western blotting ; cellular transferrin ( Tf ) binding sites were measured by ( 125 ) 1 Tf binding assay . ^^^ Although fHFE expression produced an increase in cellular TfR protein , cell surface and intracellular Tf binding sites were actually decreased in these cells . ^^^ CONCLUSION : Our studies suggest that expression of wild type HFE in cells produces a decrease in ( 67 ) Ga uptake due to a reduction in available Tf binding sites for ( 67 ) Ga Tf on the TfR . ^^^ Recent studies have revealed that the wild type hemochromatosis protein ( HFE ) interacts with the transferrin receptor ( TfR ) and modulates TfR mediated iron uptake by cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE , the protein that is mutated in hereditary haemochromatosis , binds to the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
IREs are found in the 5 ' untranslated region ( UTR ) of ferritin ( Ft ) and mitochondrial aconitase ( m Aco ) mRNAs , and in the 3 ' UTR of transferrin receptor ( TfR ) and divalent metal transporter 1 ( DMT 1 ) mRNAs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
AIM : This study compared transferrin receptor ( TfR ) concentrations with iron parameters relative to a child ' s intake of cow ' s milk and follow on formula . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The interface between the two types of regulatory input by insulin is suggested to be the budding of GLUT 4 from the transferrin receptor ( TfR ) containing , recycling endosome . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Coimmunoprecipitation studies using solubilized cell extracts demonstrated that transferrin ( Tf ) competed with HFE for binding to the transferrin receptor ( TfR ) similar to previous in vitro studies using soluble truncated forms of HFE and the TfR . ^^^ At concentrations of Tf approaching those found in the blood , no differences in Tf binding to cells were detected , which is consistent with the lower binding constant of HFE for TfR versus Tf . ^^^ However , cells expressing HFE still showed a decrease in Tf mediated iron uptake at concentrations of Tf sufficient to dissociate HFE from the TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) facilitates cellular iron uptake by mediating endocytosis of its ligand , iron loaded transferrin . ^^^ We have previously shown that mouse embryos homozygous for a disrupted transferrin receptor allele ( TfR / ) die of anemia before embryonic day 12 . 5 , although most other embryonic tissues appear to be developing normally . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Concentrations of hemoglobin , serum ferritin ( SF ) , and serum transferrin receptor ( TfR ) were measured at baseline and after 3 and 6 mo . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of the study was to work out a method for determining the soluble transferrin receptor ( TfR ) on the basis of the direct immune enzyme analysis , including its dynamic testing in patients with anemia of various etiologies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined transferrin receptor ( TfR ) 1 and TfR 2 mRNA expression in 50 acute myeloid leukemia ( AML ) patients by RT PCR , with primers specific for exons 15 17 ( TfR 1 ) , 3 5 ( TfR 2 alpha ) and 4 5 ( TfR 2 beta ) of the corresponding gene . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We undertook a comparative study of the presence of the epidermal growth factor receptor ( EGFR ) , interleukin 13 receptor ( IL13R ) , interleukin 4 receptor ( IL4R ) , and transferrin receptor ( TfR ) determined by immunofluorescence microscopy among fresh frozen tumor samples from 38 patients with high grade gliomas ( glioblastoma multiforme or anaplastic astrocytoma ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Notable findings have included the identification of the transferrin receptor TfR as the cell surface receptor for canine parvovirus and feline panleukopenia virus , and also the finding that specific binding to the canine TfR led to the emergence of canine parvovirus as a new pathogen in dogs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Feline panleukopenia virus ( FPV ) and its host range variant , canine parvovirus ( CPV ) , can bind the feline transferrin receptor ( TfR ) , while only CPV binds to the canine TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
TfR specific binding and uptake were determined using 125I Tf and 59Fe Tf treatment , respectively . ^^^ Apical to basolateral ( A to B ) transferrin receptor ( TfR ) mediated transcytosis was determined by dosing the apical compartment with 1 . 5 microg / mL of 125I Tf or 125I GCSF Tf . ^^^ Nonspecific TfR independent transport of 125I Tf and 125I GCSF Tf was determined in parallel by including 150 microg / mL of nonradiolabeled Tf . ^^^ The effects of brefeldin A ( BFA ) on TfR distribution and ( A to B ) transport of 125I Tf , 125I GCSF and 125I GCSF Tf was studied by including the agent in the apical fluid at 1 microg / mL . ^^^ In contrast , BFA treatment significantly altered the endocytosis of TfR , reducing the basolateral uptake of 59Fe Tf while greatly increasing the apical uptake of 59Fe Tf . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Therefore , the expression of ferritin and transferrin receptors ( TfR ) were sought in the lungs and hearts of rodents treated with lipopolysaccharide ( LPS ) , and measurements of TfR and ferritin protein expression were taken from lung biopsy specimens from patients with ARDS and appropriate controls . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This antibody was depressive on cell growth in serum free medium in the presence of limiting amounts of Tf ( h ) , but it did not inhibit the binding of Tf ( h ) alkaline phosphatase ( AP ) conjugate to the Tf receptor ( TfR ) in a cellular enzyme linked immunosorbent assay ( CELISA ) system . ^^^ Moreover , the detectability of Tf ( h ) TfR on the cell surface via Tf bound TRC 2 suggested that the antibody may inhibit the rapid internalization of this complex . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
H2O2 mediated intracellular dichlorofluorescein fluorescence and apoptosis were enhanced by the transferrin receptor ( TfR ) mediated iron uptake . * NO inhibited the TfR mediated iron uptake , dichlorofluorescein fluorescence , and apoptosis in H2O2 treated cells . * NO increased the proteasomal activity and degradation of nitrated TfR via ubiquitination . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the ACD group , NO concentration and NO synthase activity in serum increased ; iron , total iron binding capacity ( TIBC ) and transferrin saturation ( TS ) in serum and ferritin in erythrocytes ( rFn ) decreased ; transferrin receptor ( TfR ) and iron in bone marrow cells decreased ; ferritin in serum and iron in liver increased and meanwhile the acotinase activity in liver decreased . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transport of iron from the mother to the fetus is essential for the normal development of the fetus and abnormalities in the transferrin receptor ( TFR ) on the placental trophoblasts might have some crucial effects on the fetal iron metabolism . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Canine cell infection is a specific property of CPV and depends on the ability of the virus to bind the canine transferrin receptor ( TfR ) , as well as other unidentified factors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast to resting T cells , human T cell lymphotropic virus type 1 ( HTLV 1 ) infected cells constitutively express high levels of surface transferrin receptor ( TfR ) . ^^^ We determined that A 24 binds TfR with an equilibrium constant ( K ' d ) of 2 . 7 nM and competes with transferrin for binding to TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Flow cytometry was performed to detect the transferrin receptor ( TfR ) expression of K 562 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To secure iron from transferrin , hepatocytes use two pathways , one dependent on transferrin receptor ( TfR 1 ) and the other , of greater capacity but lower affinity , independent of TfR 1 . ^^^ Suppression of TfR 1 does not lead to down regulation of TfR 2 , a recently described second transferrin receptor of as yet uncertain function . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The PILs are targeted across the blood brain barrier and across the tumor cell membrane in vivo with a monoclonal antibody ( MAb ) to the rat transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : A 7 kb expression plasmid encoding for rat tyrosine hydroxylase ( TH ) was encapsulated in PILs targeted with either the murine OX 26 monoclonal antibody ( MAb ) to the rat transferrin receptor ( TfR ) or with the mouse IgG2a isotype control antibody . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
It also examined whether TPC is associated with increasing hypoxia inducible factor 1alpha ( HIF 1alpha ) levels and alterations in two HIF 1alpha target genes , transferrin ( Tf ) and transferrin receptor ( TfR ) , within the brain . ^^^ HIF 1alpha , Tf , and TfR were measured by Western blot analysis and immunohistochemistry . ^^^ Thrombin also increases Tf and TfR levels in the brain . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cell surface TfR binds to circulating iron loaded transferrin ( Fe Tf ) and transports it to acidic endosomes , where low pH promotes iron to dissociate from transferrin ( Tf ) in a TfR assisted process . ^^^ The iron free form of Tf ( apo Tf ) remains bound to TfR and is recycled to the cell surface , where the complex dissociates upon exposure to the slightly basic pH of the blood . ^^^ Fe Tf competes for binding to TfR with HFE , the protein mutated in the iron overload disease hereditary hemochromatosis . ^^^ We used a quantitative surface plasmon resonance assay to determine the binding affinities of an extensive set of site directed TfR mutants to HFE and Fe Tf at pH 7 . 4 and to apo Tf at pH 6 . 3 . ^^^ These results confirm the previous finding that Fe Tf and HFE compete for the receptor by binding to an overlapping site on the TfR helical domain . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated the role of transferrin receptor ( TfR ) and iron in modulating the expression of alpha synuclein ( alpha syn ) in MPP ( + ) induced oxidative stress and apoptosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The Tb ( 3 ) complex of the iron transport protein transferrin ( Tb ( 2 ) Tfr ) exhibits strongly sensitised , sharp line luminescence from f f states following multiphoton excitation via two tyrosinate residues directly co ordinated to the lanthanide ion . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The purpose of this study was to explore the effects of recombinant human EPO ( rhEPO ) on the expression of transferrin receptor ( TfR , CD ( 71 ) antigen ) of leukemic cell K 562 and its relation to cell cycle . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This , in turn , stimulated transferrin receptor ( TfR ) dependent iron signaling via activation of the iron regulatory protein / iron responsive element interaction . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
It also examines whether TPC might be protective by altering iron handling within the brain , particularly through modulating transferrin ( Tf ) and transferrin receptor ( TfR ) levels . ^^^ Western blot analysis and immunohistochemistry were used for Tf and TfR measurements . ^^^ We found that TPC reduces lysed RBC induced brain edema and upregulates both Tf and TfR levels in the brain . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , we postoperatively identified TfR ( transferrin receptor ) staining and Ki 67 proliferative index in patients with intracranial meningiomas and evaluated the correlation between these parameters and the recurrence or malignant proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Because overexpression of endogenous transferrin receptor ( TfR ) has been qualitatively described for various cancers and is presumably due to malignant transformation of cells , TfR may represent a suitable target for application of molecular imaging technologies to increase detection of smaller tumors . ^^^ Biochemical analysis of the interaction of imaging probes with cells overexpressing the TfR demonstrated that the extent of accumulation , and therefore probe efficacy , is dependent on the nature of the chemical cross link between transferrin and the iron oxide particle . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) has been identified as a candidate IgA 1 receptor expressed on human mesangial cells ( HMC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron , insoluble as free Fe ( 3+ ) and toxic as free Fe ( 2+ ) , is distributed through the body as Fe ( 3+ ) bound to transferrin ( Tf ) for delivery to cells by endocytosis of its complex with transferrin receptor ( TfR ) . ^^^ Using cryo electron microscopy , we have produced a density map of the TfR Tf complex at subnanometer resolution . ^^^ An atomic model , obtained by fitting crystal structures of diferric Tf and the receptor ectodomain into the map , shows that the Tf N lobe is sandwiched between the membrane and the TfR ectodomain and that the C lobe abuts the receptor helical domain . ^^^ The structure of TfR Tf complex helps account for known differences in the iron release properties of free and receptor bound Tf . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We show that iron at a physiological dose stimulates ferritin synthesis without altering the transferrin receptor ( TfR ) mRNA levels of these cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Application of FAC to astrocyte cultures caused a strong increase in the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor ( TfR ) , which is involved in the transferrin mediated uptake of iron into cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
PURPOSE : The purpose of this study was to investigate the transferrin receptor ( TfR ) mediated transepithelial transport of G CSF transferrin ( Tf ) conjugate in cultured enterocyte like Caco 2 monolayers and the myelopoietic effect of subcutaneously and orally administered G CSF Tf in BDF 1 mice . ^^^ TfR mediated transcytosis wa measured by using 125I G CSF Tf and analyzing the downstream compartment by gamma counter . ^^^ CONCLUSIONS : Our data indicate that G CSF Tf is transported across Caco 2 monolayers by TfR specific processes at a rate that is significantly higher than the nonspecific flux of G CSF . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A new index , the ' sTfR E index ' [ the ratio of serum sTfR level ( ng / ml ) to BM cellularity ( % ) 10 BM erythroblasts ( % ) ] is proposed , which is expected to reflect the number of transferrin receptors ( TfR ) on the cell membrane per BM erythroblast . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recent results showed that CPV expanded its host range by binding to the canine transferrin receptor ( Tfr ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The sHFE monochain was effective in reducing Tf uptake into cells , however this did not correlate to any changes in TfR or ferritin synthesis , in contrast to the HFE induced increase and decrease of TfR and ferritin , respectively . ^^^ A non classical class 1 MHC molecule , the hemochromatosis factor HFE , has been shown to regulate iron metabolism , potentially via its direct interaction with the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The GFAP TH or SV 40 TH expression plasmids were encapsulated in the interior of 85 nm PILs , which were targeted across both the BBB and the neuronal cell membrane with a monoclonal antibody ( mAb ) to the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin ( Fe Tf ) and HFE , the protein mutated in patients with the iron overload disorder hereditary hemochromatosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) is completely lost from the red cell surface by its segregation in the secreted vesicles where it interacts with the heat shock cognate 70 kDa protein ( hsc 70 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NO ) during hydrogen peroxide ( H ( 2 ) O ( 2 ) ) mediated transferrin receptor ( TfR ) dependent iron signaling and apoptosis in C ( 2 ) ceramide ( C ( 2 ) cer ) treated bovine aortic endothelial cells ( BAECs ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : The serum transferrin receptor ( TfR ) presents certain advantages over other parameters of cellular iron status because it does not vary in acute or chronic diseases . ^^^ OBJECTIVE : To establish reference ranges of TfR in healthy children for our laboratory , to define the distribution of this variable in children with acute illness and in those with iron deficiency , and to evaluate the diagnostic yield of TfR , the transferrin receptor / ferritin ratio ( TfR / F ) and the transferrin receptor ferritin index ( TfR F ) in distinguishing ferropenic from infectious anemia . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
RESULTS : Ferritin , divalent metal transporter 1 , ferroportin , and transferrin receptor ( TfR ) were decreased in RLS neuromelanin cells compared with control . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The TfR and its ligand transferrin have well described pathways of endocytosis and recycling . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE affects the interaction of transferrin bound iron with transferrin receptors ( TfR ) thereby modulating iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR , CD 71 ) is normally present in the plasma membrane and recycling endosomes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Elevated transferrin receptor ( TfR ) concentration may be either because of iron deficiency or an increased rate of erythropoiesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To clarify the iron metabolism of HD patients , proteins involved in iron import ( transferrin receptor [ TfR ] ) , as well as export ( ferroportin 1 ) , were investigated in polymorphonuclear leukocytes ( PMNLs ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
PURPOSE : The expression level of the transferrin receptor ( TfR ) on brain capillary endothelial cells ( BCECs ) and the endocytosis of 125I transferrin ( 125I Tf ) by this receptor was investigated . ^^^ RESULTS : On BCECs , the TfR is expressed extracellularly ( B ( max ) of 0 . 13 fmol / microg cell protein ) , but also has a large intracellular pool ( total B ( max ) of 1 . 37 fmol / microg cell protein ) , and is actively endocytosing Tf via clathrin coated vesicles . ^^^ CONCLUSIONS : The TfR is expressed on BCECs and actively endocytoses Tf , making it a suitable target for drug delivery to the bloodbrain barrier and the CNS . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
RESULTS : TfR expression of MSCs was demonstrated by flow cytometry assay , immuno fluorescent staining and receptor binding assay in vitro . ( 125 ) 1 Tf ( Fe ) ( 2 ) bound to hMSCs with a equilibrium dissociation constant ( KD ) of ( 0 . 98+ / 0 . 12 ) nmol / L and a maximal density of binding sites ( B ( max ) ) of ( 107 702+ / 6 226 ) sites per cell . ^^^ To track implanted hMSCs with radionuclide imaging techniques in vivo , TfR was a suitable target for imaging and radioiodinated Tf ( Fe ) ( 2 ) was a feasible tracer . . ^^^ OBJECTIVE : To determine transferrin receptor ( TfR ) expression of human mesenchymal stem cells ( MSCs ) in vitro and after transplantation in rabbit spinal cord , and to detect implanted MSCs by in vitro autoradiography . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , M CSF treatment of macrophages rapidly increased the localization of TfR to the cell surface but did not alter the relative rate of Tf internalization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of this study was to test the hypothesis that mitochondria targeted antioxidants inhibit peroxide induced oxidative stress and apoptosis in bovine aortic endothelial cells ( BAEC ) through enhanced scavenging of mitochondrial reactive oxygen species , thereby blocking reactive oxygen species induced transferrin receptor ( TfR ) mediated iron uptake into mitochondria . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The objective of this study was to assess iron status in rural Kenya using `` field friendly ' ' methods for capillary blood , including an improved dried blood spot assay for transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This transcytosis is transferrin receptor ( TfR ) mediated with use of a bifunctional adaptor , soluble coxsackie adenovirus receptor ( sCAR ) Tf , and is both temperature and iron dependent . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The efficient cellular uptake of Tf shows it has potential in the delivery of anti cancer drugs , proteins , and therapeutic genes into proliferating malignant cells that overexpress transferrin receptor ( TfR ) . ^^^ Visual evidence showed that the transport of apo Tf into K 562 cells is a TfR mediated process . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The PIL carrying the gene was targeted to organs with the rat 8D3 monoclonal antibody ( MAb ) to the mouse transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of ferrous iron and transferrin was reversed by monoclonal antibody RVS 10 against the transferrin receptor ( TfR ) , which competes with transferrin for binding to TfR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study focuses on the effects of IVAA supplementation on serum concentrations of soluble transferrin receptors ( TfR ) on the basis of the hypothesis that an increase of labile iron in the cytosol will lead to inhibition of TfR expression . ^^^ In a stepwise multivariate analysis , serum EPO and transferrin saturation ( TSAT ) were the two independent predictors for serum TfR in HD patients ( r ( 2 ) = 0 . 510 , P < 0 . 001 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously shown that the transferrin receptor ( TfR ) is specifically up regulated in T . gondii infected human fibroblasts but not in host cells infected with the bacterial pathogens Salmonella Typhimurium and Chlamydia trachomatis . ^^^ The increased iron availability due to treatment with holotransferrin and FeNTA did not prevent TfR induction nor was the transferrin independent iron transporter NRAMP 2 up regulated in infected host cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Opposing roles of GS 32 and syndapin 2 in regulating the surface level of transferrin receptor ( TfR ) were observed . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We report here that monocyte derived DC ( Mo DC ) express another IgA receptor ( IgA R ) , the transferrin receptor ( TfR ) , even in the absence of DC proliferation in vitro . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We measured hemoglobin ( Hb ) , ferritin , transferrin receptor ( TfR ) , and vitamins B 6 , B 12 , and folate concentrations before pregnancy in 405 Chinese women ( median time from sample collection to gestation end = 316 d ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The latter comprised streptavidin ( SA ) and the murine OX 26 monoclonal antibody to the rat transferrin receptor ( TfR ) , which were joined by a thiol ether linker . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Increased levels of transferrin receptors ( TfR ) and soluble TfR ( sTfR ) are reliable indicators of iron deficiency anemia and conditions with enhanced erythropoietic activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron may populate distinct hepatocellular iron pools that differentially regulate expression of proteins such as ferritin and transferrin receptor ( TfR ) through iron regulatory mRNA binding proteins ( IRPs ) , and may additionally regulate uptake and accumulation of non transferrin bound iron ( NTBI ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The kinetics and thermodynamics of Bi ( 3 ) exchange between bismuth mononitrilotriacetate ( BiL ) and human serum transferrin as well as those of the interaction between bismuth loaded transferrin and transferrin receptor 1 ( TFR ) were investigated at pH 7 . 4 8 . 9 . ^^^ The interaction of bismuth loaded transferrin with TFR occurs in a single very fast kinetic step with a dissociation constant K ( d ) of 4 + / 0 . 4 microM , a second order rate constant k ( d ) of ( 2 . 2 + / 1 . 5 ) 10 10 ( 8 ) M ( 1 ) s ( 1 ) , and a first order rate constant k ( d ) of 900 + / 400 s ( 1 ) . ^^^ This mechanism is different from that observed with the ferric holotransferrin and implies that the interaction between TFR and bismuth loaded transferrin probably takes place on the helical domain of the receptor which is specific for the C site of transferrin and HFE . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , Nef modulates the trafficking of the transferrin receptor ( TfR ) , the prototypical recycling surface protein , indicating that it also disturbs the function of this compartment . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
PURPOSE : To investigate if the cross linking of transferrin receptor ( TfR ) induced by Tf oligomers alters the endocytosis of receptor ligand complexes in cultured tumor cells and hence increases intracellular drug release . ^^^ Cell surface binding and competition experiments with 125I Tf for TfR binding were studied to demonstrate that Tf oligomers maintain specificity of the TfR binding . ^^^ To determine the degradation of Tf oligomers in TfR mediated endocytosis , cultured tumor cells were pulsed for 15 min with 125I Tf oligomers and chased for 2 h at 37 degrees C in the presence of excess unlabeled Tf . ^^^ To investigate if the alteration of TfR trafficking facilitates the intracellular release of the drug from the Tf conjugated form , methotrexate ( MTX ) was conjugated to Tf oligomer ( Agg Tf MTX ) and its antiproliferative activity was compared with monomeric Tf MTX ( Mono Tf MTX ) in human colon carcinoma ( Caco 2 ) cells , human breast adenocarcinoma ( MCF 7 ) cells , wild type Chinese hamster ovary ( CHO ) cells , and MTX resistant CHO ( CHO MTX RII ) cells . ^^^ RESULTS : TfR mediated degradation of Tf oligomers was higher than that of monomeric Tf in both Caco 2 and MCF 7 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Effects on plasma , milk , liver and mammary gland Fe and vitamin A concentrations , and divalent metal transporter 1 ( DMT 1 ) , ferroportin ( FPN ) , ferritin ( Ft ) , and transferrin receptor ( TfR ) expression were determined . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The purpose of this study was to investigate the usefulness of soluble serum transferrin receptor ( TfR ) concentration , TfR index and log TfR : ferritin ratio ( TfR outcomes ) in detecting tissue Fe deficiency among breast feeding Otomi women residing in Capulhuac , Mexico ( 2800 m above sea level ) and to determine whether folate deficiency modifies the interpretation of these data . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we show that iron uptake mediated by the transferrin receptor ( TfR ) delivers a signal that leads to IFN gammaR 2 internalization and thus plays an essential role in attenuating activation of the IFN gamma / STAT1 pathway in human T lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , the inhibitory effects of sodium ascorbate on intracellular iron levels are blocked by addition of transferrin , suggesting that transferrin receptor ( TfR ) dependent pathway of iron uptake may be regulated by sodium ascorbate . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We transfected Drosophila Schneider line 2 ( S 2 ) cells with the human low density lipoprotein ( LDL ) receptor ( LDLR ) and transferrin ( Tf ) receptor ( TfR ) , and used endocytosis of LDL and Tf as markers . ^^^ Fluorescence microscopy analysis revealed that LDL and Tf are internalized by S 2 cells transfected with LDLR or TfR , respectively . ^^^ Similar results were obtained with Spodoptera frugiperda Sf 9 cells that were transfected with TfR , suggesting that Tf is retained intracellularly by both cell lines . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : The HFE protein interacts with the transferrin receptor ( TfR ) to regulate cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The liposome is targeted across the BBB via attachment to the tips of 1 2 % of the PEG strands of a receptor specific monoclonal antibody ( mAb ) directed at a BBB receptor , such as the insulin receptor or transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Bacterial beta galactosidase ( 116 kDa ) was conjugated to the rat 8D3 mAb to the rat transferrin receptor ( TfR ) via a streptavidin biotin linkage . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In HFE / mice hepcidin formation was diminished upon iron challenge which was associated with decreased hepatic transferrin receptor ( TfR ) 2 levels . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : Although transferrin receptor ( TfR ) and zinc protoporphyrin ( ZnPP ) are often used to define iron status in school age children in developing countries , the diagnostic cutoffs for this age group are uncertain . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Some receptors , like the transferrin receptor ( TfR ) , are constitutively internalized and recycled to the plasma membrane . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The PNA was monobiotinylated , and was attached to a monoclonal antibody ( MAb ) to the transferrin receptor ( TfR ) via a biotin streptavidin linkage . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory proteins ( IRPs ) 1 and 2 posttranscriptionally regulate expression of transferrin receptor ( TfR ) , ferritin , and other iron metabolism proteins . ^^^ TfR expression in erythroid precursors of IRP 2 / mice is reduced , and bone marrow iron stores are absent , even though transferrin saturation levels are normal . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study , hepatic messenger RNA ( mRNA ) expression of transferrin receptor ( TfR ) 1 , TfR 2 , and ferroportin ( FP ) 1 was measured in patients with chronic hepatitis ( CH ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We found that phoshatidylinositol 3 kinase ( PI 3 K ) markedly contributes to the increased surface expression of bovine transferrin receptor ( TfR ) on Theileria infected lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The in vitro studies demonstrated that the purified G CSF Tf fusion protein possesses the activity of both Tf receptor ( TfR ) binding in Caco 2 cells and G CSF dependent stimulation of NFS 60 cell proliferation . ^^^ Furthermore , coadministration of free Tf abolished the increase of ANC by orally delivered G CSF Tf , suggesting that the recombinant protein is absorbed via a TfR mediated process in the gastrointestinal tract . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two proteins involved in iron metabolism that are expressed in the kidney are the divalent metal transporter , DMT 1 ( Slc11a2 ) , and the Transferrin Receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study was designed to test the hypothesis that manganese exposure may change the binding affinity of iron regulatory proteins ( IRPs ) to mRNAs encoding transferrin receptor ( TfR ) , thereby influencing iron transport at the blood CSF barrier . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Therefore , undifferentiated PC 12 cells were exposed to 0 200 microM Mn ( 2 ) chloride or Mn ( 3 ) pyrophosphate for 24 h , after which cellular manganese levels were measured along with measures of cell viability , function , and cytotoxicity ( trypan blue exclusion , medium lactate dehydrogenase ( LDH ) , 8 isoprostanes , cellular ATP , dopamine , serotonin , H ferritin , transferrin receptor ( TfR ) , Mn superoxide dismutase ( MnSOD ) , and copper zinc superoxide dismutase ( CuZnSOD ) protein levels ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
AIM : To construct fusion protein of a single chain antibody ( scFv ) against transferrin receptor ( TfR ) with alkaline phosphatase ( AP ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin ( Tf ) is one suitable ligand to be conjugated to drug delivery systems to achieve site specific targeting , due to its specific binding to transferrin receptors ( TfR ) , expressed on several cell types of therapeutic interest . ^^^ Transferrin ( Tf ) is one suitable ligand to be conjugated to drug delivery systems to achieve site specific targeting , due to its specific binding to transferrin receptors ( TfR ) , expressed on several cell types of therapeutic interest . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation ( C282Y or H63D ) , other investigators have concluded there is no increased risk , or that any increase is dependent on polymorphisms in HFE interacting genes such as the transferrin receptor ( TFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Oligomeric transferrin ( Tf ) was used to investigate the effect that cross linking of transferrin receptors ( TfR ) has on intracellular trafficking of the Tf TfR complex and to determine whether or not the Tf oligomer would be a better carrier than monomeric Tf for the oral delivery of protein drugs . ^^^ These results demonstrate that the cross linking of TfR induced by the binding of the oligomeric Tf alters the intracellular trafficking and increases the intracellular retention of Tf TfR complexes in polarized Caco 2 cells . ^^^ The alteration of TfR trafficking could conceivably have caused the increase of insulin transport across the intestinal barrier when Agg Tf S S In was administered orally to STZ induced diabetic rats . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TfR ) was identified previously as an IgA 1 receptor , and it was found that , in biopsies of patients with IgAN , TfR is overexpressed and co localizes with IgA 1 mesangial deposits . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In situ analysis of transferrin receptor ( TfR ) mRNA showed staining in BALT alone . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) , an essential transport protein that enables cells to satisfy their need of iron , is upregulated in cancer cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron regulatory protein 1 ( IRP 1 ) functions as translational regulator that plays a central role in coordinating the cellular iron metabolism by binding to the mRNA of target genes such as the transferrin receptor ( TfR ) the major iron uptake protein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The increased activity of iron regulatory protein 1 after nickel exposure stabilized and increased transferrin receptor ( Tfr ) mRNA and antagonized the iron induced ferritin light chain protein synthesis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Whereas the cellular receptor for MEV is expected to be the transferrin receptor ( TfR ) , the cellular receptor for ADV has not been clearly identified . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron loaded transferrin ( Tf ) . ^^^ Soluble TfR was isolated from human plasma , and complex formation between sTfR and Tf was studied by stepwise complex construction and by FPLC gel filtration . ^^^ Transferrin receptor ( TfR ) is a dimeric transmembrane protein that provides iron transport from plasma to cells by binding and internalization of iron loaded transferrin ( Tf ) . ^^^ Soluble transferrin receptor ( sTfR ) is an extracellular part of the TfR molecule that is truncated from the cell surface and released into the blood stream . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We analyzed data from 9 randomized iron intervention trials to determine which of the following indicator ( s ) of iron status show the largest response in a population : hemoglobin ( Hb ) , ferritin , transferrin receptor ( TfR ) , zinc protoporphyrin ( ZPP ) , mean cell volume ( MCV ) , transferrin saturation ( TS ) , and total body iron store . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) 1 and 2 mRNA and CD 71 ( TfR 1 ) expression was analyzed in 118 CLL patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Aluminum ( Al ) and iron ( Fe ) share several physicochemical characteristics and they both bind to transferrin ( Tf ) , entering the cell via Tf receptors ( TfR ) . ^^^ Previously , we found similar values of affinity constant for the binding of TfR to Tf carrying either Al or Fe . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Mito CP inhibited both H ( 2 ) O ( 2 ) and lipid peroxide induced inactivation of complex 1 and aconitase , overexpression of transferrin receptor ( TfR ) , and mitochondrial uptake of ( 55 ) Fe , while restoring the mitochondrial membrane potential and proteasomal activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) has been shown to be significantly overexpressed in different types of cancers . ^^^ The binding site of GA on TfR is independent of the transferrin binding site , and it appears that GA potentially inhibits TfR internalization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hemoglobin ( Hb ) , mean corpuscular volume , ferritin , iron , iron transferrin saturation , and soluble transferrin receptor ( TfR ) were measured , and TfR F index was calculated . ^^^ The mean soluble transferrin receptor concentration was 1 . 9 + / . 8 mg / L , and the mean TfR F index was 1 . 21 + / . 57 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Divalent metal transporter 1 ( DMT 1 ) and transferrin receptor ( TfR ) might play a key role in non transferrin bound iron ( NTBI ) and transferrin bound iron ( Tf Fe ) uptake by neuronal cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On the other hand , syntaxin 10 reciprocally co immunoprecipitated endosomal syntaxin 12 / 13 , and knockdown of syntaxin 10 expressions affects the surface expression of transferrin receptor ( TfR ) and seems to induce the formation of an immobile TfR pool . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Conversely , Abi 1 and N WASP , but not WAVE , regulate actin based vesicular transport , epidermal growth factor receptor ( EGFR ) endocytosis , and EGFR and transferrin receptor ( TfR ) cell surface distribution . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction ( RT PCR ) studies revealed that the iron containing PA coal downregulated levels of transferrin receptor ( TfR ) mRNA in A 549 cells , which was partially restored by the addition of calcite . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Diverse iron transporters , including iron import proteins ( transferrin receptor [ TfR ] and divalent metal transporter 1 [ DMT 1 ] ) and an iron export protein ( ferroportin 1 [ FP 1 ] ) coexist in human umbilical endothelial cells ( HUVECs ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the incidence of anemia detected in familial Mediterranean fever ( FMF ) and the effect of disease activity and colchicine therapy along with interleukins to laboratory tests , including serum transferrin receptor ( TfR ) , in the diagnosis of anemia seen in FMF in children . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
ACAP 1 has been shown recently to function as a transport effector in the cargo sorting of transferrin receptor ( TfR ) that undergoes constitutive recycling . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using the avidin ( SA ) biotin ( BIO ) technology , we describe here the design of chitosan ( CS ) nanospheres conjugated with poly ( ethylene glycol ) ( PEG ) bearing the OX 26 monoclonal antibody whose affinity for the transferrin receptor ( TfR ) may trigger receptor mediated transport across the BBB . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study , we have investigated the glucose induced alteration of iron transporters , divalent metal transporter 1 ( DMT 1 ) , iron regulated transporter protein 1 ( IREG 1 ) , and transferrin receptor ( TfR ) , in endothelial cell iron accumulation and oxidative stress . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We therefore investigated the expression of a primary nutrient transporter , the GLUT 1 glucose transporter and two in vitro markers of hypoxia ( erythropoietin receptor , EPO R , and transferrin receptor , TfR ) in the syncytial microvillous ( MVM ) and basal membrane fractions ( BMF ) of 13 high ( 3100 m ) and 12 low ( 1600 m ) altitude placentas from normal term pregnancies . ^^^ EPO R , TfR and GLUT 1 were examined by immunoblotting and maternal circulating erythropoietin and transferrin by ELISA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To investigate this possibility , the effects of L DOPA on the expression of iron influx proteins [ transferrin receptor ( TfR ) and divalent metal transporter 1 ( DMT 1 ) ] , iron efflux protein ( ferroportin 1 ) , and iron uptake in C 6 glioma cells were determined in this study using Northern blot and Western blot analysis and the calcein method . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here , we report that TTP ( SH3BP4 ) , a SH 3 containing protein , specifically regulates the internalization of the transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recently , recombinant ATM expression in ATM deficient cells was found to decrease transferrin receptor ( TfR ) expression , suggesting that deletion of the chromosomal region carrying ATM results in increased TfR expression . ^^^ Our hypothesis may also partially explain why gallium , an atomically iron like toxic metal that binds to transferrin and the TfR is incorporated into cells and was previously demonstrated to have anti tumor activity in patients with lymphomas refractory to other chemotherapeutic treatments . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
RESULTS : Between baseline and 35 wk , geometric mean serum ferritin ( SF ) increased significantly in all 3 groups receiving iron ( P < 0 . 01 ) , and geometric mean serum transferrin receptor ( TfR ) decreased significantly in the groups receiving ferrous sulfate and electrolytic iron ( P < 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The structural allostery and binding interface for the human serum transferrin ( Tf ) * transferrin receptor ( TfR ) complex were identified using radiolytic footprinting and mass spectrometry . ^^^ First , we report characteristic oxidations of acidic residues in the C lobe of native Tf and basic residues in the helical domain of TfR that were suppressed as a function of complex formation ; this confirms ionic interactions between these protein segments as predicted by cryo EM data and demonstrates a novel method for detecting ion pair interactions in the formation of macromolecular complexes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The molecular basis of the transferrin ( TF ) transferrin receptor ( TFR ) interaction is not known . ^^^ The C lobe of TF is required to facilitate binding to the TFR and both the N and C lobes are necessary for maximal binding . ^^^ Furthermore , mAb F 11 inhibits the binding of TF to TFR on HeLa cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR / CD71 ) deserves attention as a selective target for cancer therapy due to its higher expression in tumors versus normal tissues . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have used the well characterized structure of the transferrin ( Tf ) transferrin receptor ( TfR ) complex to study how specimen preparation techniques influence the outcome of single particle EM reconstructions . ^^^ The Tf TfR complex is small ( 290kDa ) and of low symmetry ( 2 fold ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Thus , in vertebrates iron is transported through the circulation bound to transferrin ( Tf ) and delivered to cells through an endocytotic cycle involving the transferrin receptor ( TfR ) . ^^^ We have previously presented a model for the Tf TfR complex in its iron bearing form , the diferric transferrin ( dTf ) TfR complex [ Cheng , Y . , Zak , O . , Aisen , P . , Harrison , S . ^^^ We were unable to improve the resolution of the apoTf TfR density map beyond 16A , most likely because of significant structural variability of Tf in its iron free state . ^^^ We have now calculated a single particle reconstruction for the complex in its iron free form , the apo transferrin ( apoTf ) TfR complex . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TfR ) is shed by an integral metalloprotease releasing a soluble form ( sTfR ) into serum . ^^^ To study the role of transferrin in this process , we investigated TfR shedding in HL 60 cells and TfR deficient Chinese hamster ovary cells transfected with human TfR . ^^^ Independent of TfR expression , sTfR release decreases with increasing ferritransferrin concentrations , whereas apo transferrin exhibits no inhibitory effect . ^^^ To investigate the underlying mechanism , we generated several TfR mutants with different binding affinities for transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In HeLa cells depleted of adaptor protein 2 complex ( AP 2 ) by small interfering RNA ( siRNA ) to the mu 2 or alpha subunit or by transient overexpression of an AP 2 sequestering mutant of Eps 15 , endocytosis of the transferrin receptor ( TfR ) was strongly inhibited . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We measured hemoglobin , erythropoietin ( EPO ) , serum transferrin receptor ( TfR ) and serum ferritin at 6 weeks , 3 and 6 months of age and hemoglobin at 9 and 12 months in 3 groups of randomly selected infants : 136 born to HIV negative mothers , and 99 born to HIV positive mothers and who were infected themselves by 6 weeks of age , and 324 born to HIV positive mothers but who did not become infected in the 6 months following birth . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Among the 21 molecules examined , the amount of transferrin receptor ( TfR ) protein was found to be 2 fold higher in UV ( r ) 1 cells compared with in RSa cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Biochemical analyses of the MRCKalpha IRE revealed that it was functional and mediated the response to iron level in the same way as transferrin receptor 1 IREs ( TfR ) did . ^^^ The level of MRCKalpha mRNA in various tissues strongly positively correlates with the level of TfR mRNA , indicating its possible role in the transferrin iron uptake pathway . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By immunofluorescence , IRAP significantly co localized with the transferrin receptor ( TfR ) , a marker for constitutively recycling endosomes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Because absorption of iron and manganese could involve similar mechanisms , transferrin ( Tf ) and transferrin receptor ( TfR ) expression in rat lungs was examined . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Under normal iron metabolism conditions , iron homeostasis is tightly controlled by inverse regulation of ferritin and transferrin receptor ( TfR ) through iron regulatory proteins ( IRP ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The beta retrovirus mouse mammary tumor virus ( MMTV ) uses transferrin receptor 1 ( TfR 1 ) to enter cells in a pH dependent mechanism , probably co trafficking with TfR 1 to an acidic compartment where virus entry occurs . ^^^ We also demonstrated that MMTV entry is independent of transferrin , iron , and the TfR 1 cofactor hereditary hematochromatosis HFE protein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
One mechanism of iron uptake is mediated by the cell surface transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here , we use a similar technique to assay the organization and distribution of another membrane bound receptor : transferrin receptor ( TFR ) and its ligand , holo transferrin ( Tfn ) , while explaining the step by step measures to be taken for successful quantitative analysis of the FRET data . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we analyzed the effect of the main polyphenol constituent of green tea , ( ) epigallocatechin 3 gallate ( EGCG ) , which possesses metal chelating and radical scavenging properties , on the regulation of the iron metabolism related proteins APP and transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Previous studies in this laboratory indicated that manganese ( Mn ) exposure in vitro increases the expression of transferrin receptor ( TfR ) by enhancing the binding of iron regulatory proteins ( IRPs ) to iron responsive element containing RNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Uptake of Tf conjugated G 3139 containing liposomes in TfR positive K 562 cells was found to be more efficient than that of the non targeted control formulation and could be blocked by excess free Tf . ^^^ In conclusion , Tf conjugated liposomes are effective delivery vehicles for G 3139 antisense oligos in TfR positive K 562 cells and warrant further investigation as an in vivo oligo delivery vehicle . . ^^^ A novel transferrin receptor ( TfR ) targeted liposomal formulation was synthesized and evaluated for the delivery of a phosphorothioate antisense oligodeoxyribonucleotide ( ODN ) ( G 3139 , oblimerson sodium , or Genasense ) to Bcl 2 in K 562 leukemia cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TfR ) is endocytosed by a clathrin mediated process and , as expected , each transfected siRNA caused a two to threefold elevation of TfR surface expression and almost completely inhibited its endocytosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In conjunction with the altered transport and distribution of essential metals within the brain , there was enhanced protein expression of the divalent metal transporter 1 ( DMT 1 ) and transferrin receptor ( TfR ) overall in the brain ; there was a general increase in each region analyzed ( cerebellum , cortex , hippocampus , midbrain , and striatum ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Genes upregulated at least threefold by B [ a ] P and containing potential XREs within their promoter regions included CYP1A1 , CYP1B1 , paired box gene 3 ( PAX 3 ) , cortactin ( CTTN / EMS1 ) , beta 2 microglobulin ( B2M ) , and transferrin receptor ( TfR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BACKGROUND : The diagnostic power of the transferrin receptor ferritin ( TfR F ) index for identification of iron responsiveness in long term hemodialysis ( HD ) patients compared with the routine markers recommended by the current US and European guidelines was appraised . ^^^ Routine iron tests ( ie , serum ferritin and transferrin saturation [ TSAT ] ) , TfR F index calculated by the ratio of soluble TfR to log ferritin level , hematocrit , hemoglobin , red blood cell count , and serum high sensitive C reactive protein were examined at baseline . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After 6 mo , serum ferritin ( SF ) and transferrin receptor ( TfR ) concentrations as well as body iron stores improved significantly in the DFS group but not in the IS GROUP ( P < 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Activation of TLR 9 by the multimeric CpG A occurs in transferrin receptor ( TfR ) positive endosomes and leads exclusively to IFN alpha production , whereas monomeric CpG B oligonucleotides localize to lysosome associated membrane protein ( LAMP ) 1 positive endosomes and promote maturation of PDCs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In iron depleted conditions , IRPs bind to IREs present in the 5 ' UTR of ferritin mRNA and the 3 ' UTR of transferrin receptor ( TfR ) mRNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The cell infection processes and host ranges of canine parvovirus ( CPV ) and feline panleukopenia virus ( FPV ) are controlled by their capsid interactions with the transferrin receptors ( TfR ) on their host cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hemoglobin , serum ferritin , soluble transferrin receptors ( TfR ) , and C reactive protein concentrations were measured at baseline and 6 mo after intervention . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
HFE is the principal regulator of iron homeostasis , and the process involves interaction with transferrin receptor ( TfR ) 1 , transferrin receptor ( TfR ) 2 , and beta 2 microglobulin ( beta2M ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In most cells , transferrin receptor ( TfR 1 ) mediated endocytosis is a major pathway for cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we use stably transfected Chinese hamster ovary cell lines expressing both HFE and beta2M or HFE alone to study the effects of beta2M on the stability and maturation of the HFE protein and on the role of HFE in transferrin receptor 1 ( TfR 1 ) mediated iron uptake . ^^^ The HFE beta2M complex did not affect the affinity of TfR 1 for transferrin or the internalization rate of transferrin bound TfR 1 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 ( TfR 1 ) and internalize iron ( Fe ) from transferrin ( Tf ) at a tremendous rate . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
AIMS : To investigate this issue , we examined concomitant variations in duodenal cytochrome b ( Dcytb ) , divalent metal transporter 1 ( DMT 1 ) , ferroportin 1 ( FPN 1 ) , hephaestin , stimulator of Fe transport ( SFT ) , HFE , and transferrin receptor 1 ( TfR 1 ) transcripts in response to different dietary iron contents in the four mouse strains C57BL / 6 , DBA / 2 , CBA , and 129 / Sv . ^^^ Strain to strain differences were observed not only in serum transferrin saturations , with C57BL / 6 mice having the lowest values , but also in hepatic iron stores and in duodenal mRNA expression of Dcytb , DMT 1 , FPN 1 , hephaestin , HFE , and TfR 1 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Human transferrin receptor 2 ( TFR 2 ) is a protein highly homologous to TFR 1 / CD71 and is endowed with the ability to bind transferrin ( TF ) with low affinity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We conclude that HFE has two mutually exclusive functions , binding to TfR 1 in competition with Tf , or inhibition of iron release . . ^^^ The HFE protein binds to transferrin receptor 1 ( TfR 1 ) in competition with transferrin , and in vitro , reduces cellular iron by reducing iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor 1 ( TfR 1 ) which mediates uptake of transferrin bound iron , is essential for life in mammals . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hence , the availability of plasma transferrin bound iron and the expression and function of transferrin receptors ( TfR 1 ) , HFE and DMT 1 should all contribute to the absorptive capacity of villus enterocytes . ^^^ In most experiments the function of the TfR 1 was assessed by the uptake of radiolabeled transferrin bound iron given intravenously . ^^^ The uptake of transferrin bound iron and expression of functional TfR 1 was shown to occur mainly in crypt cells and to be proportional to the plasma concentration of iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor 1 ( TfR 1 ) and putative stimulator of Fe transport ( SFT ) expression in iron deficiency and overload : an overview . ^^^ Transferrin Receptor 1 ( TfR 1 ) and putative Stimulator of Fe Transport ( SFT ) represent two different proteins involved in iron metabolism in mammalian cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Considering the high homology of MTf to Tf , it is possible to suggest that sMTf could bind to the high affinity transferrin receptor 1 ( TfR 1 ) or lower affinity TfR 2 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effects of cellular proliferation on the uptake of transferrin bound iron ( Tf Fe ) and expression of transferrin receptor 1 ( TfR 1 ) and transferrin receptor 2 ( TfR 2 ) were investigated using a human hepatoma ( HuH 7 ) cell line stably transfected with TfR 1 antisense RNA expression vector to suppress TfR 1 expression . ^^^ At transferrin ( Tf ) concentrations of 50 nmol / L and 5 micromol / L , when Tf Fe uptake occurs by the TfR 1 and TfR 1 independent ( NTfR 1 ) mediated process , respectively , the rate of Fe uptake by proliferating cells was approximately 250 % that of stationary cells . ^^^ The maximum binding of Tf by both TfR 1 and NTfR 1 mediated processes by proliferating cells was increased significantly to 160 % that of stationary cells . ^^^ In conclusion , an increase in Tf Fe uptake by TfR 1 mediated pathway by proliferating cells was associated with increased TfR 1 mRNA and protein expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Levels of type 1 hereditary hemochromatosis gene ( HFE ) , transferrin , hepcidin , transferrin receptors 1 and 2 ( TfR 1 , TfR 2 ) , ferroportin 1 ( FPN 1 ) , divalent metal transporter 1 ( DMT 1 ) , natural resistance associated macrophage protein 1 ( Nramp 1 ) , ceruloplasmin , hephaestin , and glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , were measured by quantitative reverse transriptase polyerase chain reaction ( qRT PCR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Co immunoprecipitation assays confirmed that IGFBP 3 binds transferrin but not directly to the transferrin receptor ( TfR 1 ) ; however , transferrin binds TfR 1 and a ternary complex is formed . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study we evaluated whether polymorphisms in the hemochromatosis gene HFE and the transferrin receptor gene TFR 1 are associated with these typical findings . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor 1 ( TfR 1 ) is a type 2 membrane protein that mediates cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Our aim was to evaluate divalent metal transporter 1 ( DMT 1 ) , duodenal cytochrome b ( Dcytb ) , ferroportin 1 ( FP 1 ) , hephaestin , and transferrin receptor 1 ( TfR 1 ) expression , as well as iron regulatory protein ( IRP ) activity in duodenal biopsies from control , anemic , and CD patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron transport is a function of the major iron transport proteins : transferrin receptor 1 ( TfR 1 ) and ferroportin 1 ( FPN 1 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The physiological role of transferrin ( Tf ) receptor 2 ( TfR 2 ) , a homolog of the well characterized TfR 1 , is unclear . ^^^ The apparently nonsaturating pathway of Tf endocytosis resembles TfR 1 independent Tf uptake , a process previously characterized in some liver cell types . ^^^ Exogenous expression of TfR 2 but not TfR 1 induces a similar biphasic pattern of Tf uptake in HeLa cells , supporting a role for TfR 2 in this process . ^^^ Immunoelectron microscopy reveals that while Tf , TfR 1 , and TfR 2 are localized in the plasma membrane and tubulovesicular endosomes , TfR 2 expression is associated with the additional appearance of Tf in multivesicular bodies . ^^^ These combined results imply that unlike TfR 1 , which recycles apo Tf back to the cell surface after the release of iron , TfR 2 promotes the intracellular deposition of ligand . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here , we report that embryonic hepcidin transgene expression decreases transferrin receptor 1 ( TfR 1 ) mRNA level in placenta , as shown by cDNA microarray analysis and quantitative RT PCR , by a mechanism which is independent of placenta iron content and iron responsive element / iron regulatory protein ( IRE / IRP ) activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Overexpression of mouse Tfr 1 , mouse Tfr 2 , and zebrafish tfr1b partially rescued hypochromia in cia embryos , establishing that each of these transferrin receptors are capable of supporting iron uptake for hemoglobin production in vivo . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We also measured in ScN2a cells significantly lower activities of iron regulatory proteins 1 and 2 ( IRP 1 and IRP 2 , respectively ) , regulators of cellular iron by sensing cytosolic free iron levels and controlling posttranscriptionally the expression of the major iron transport protein transferrin receptor 1 ( TfR 1 ) and the iron sequestration protein ferritin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression pattern was very different from that of mouse transferrin receptor 1 ( TfR 1 ) mRNA , which was found at high levels in the spleen and embryo . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Brain extracts from these rats and from P 50 rats from a post weaning model were compared by immunoblotting for transferrin receptor ( TfR 1 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , alterations in iron homeostasis , including lower transferrin receptor 1 ( TfR 1 ) levels , altered TfR 1 trafficking , an ' iron starvation ' gene expression profile and low iron regulatory protein ( IRP ) binding activity are independent of LOS . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To understand the role of hemochromatosis and transferrin receptor system mutations in breast cancer , we analyzed 19 sequence variations at HFE , TFR 1 , TFR 2 , and FPN 1 and compared genotype frequencies between cases and controls in a German population . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : To obtain information on the tissue distribution and quantitative expression of proteins involved in duodenal iron trafficking , we determined the expression of divalent metal transporter 1 ( DMT 1 ) , ferroportin 1 ( FP 1 ) and transferrin receptor ( TfR 1 ) by means of immunohistochemistry and real time PCR in duodenal biopsies of this patient . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A reduction in transferrin receptor 1 ( TfR 1 ) mRNA levels in the bone marrow of Irp 2 / mice can plausibly explain the microcytosis by an intrinsic defect in erythropoiesis due to a failure to adequately protect TfR 1 mRNA against degradation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
TfR 1 ( transferrin receptor 1 ) mediates the uptake of transferrin bound iron and thereby plays a critical role in cellular iron metabolism . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , the level and distribution of transferrin receptor 1 ( TfR 1 ) and ferritin in colorectal carcinoma and in normal colon epithelium has been determined relative to the tumor stage and iron status of patients using immunohistochemical staining methods . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , transferrin receptor 1 ( TfR 1 ) was fused to peptide carrier protein ( PCP ) , and the TfR 1 PCP fusion protein was specifically labeled with fluorophore Alexa 488 by Sfp . ^^^ The trafficking of transferrin TfR 1 PCP complex during the process of transferrin mediated iron uptake was imaged by fluorescence resonance energy transfer between the fluorescently labeled transferrin ligand and TfR 1 receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two types of mammalian transferrin receptor , TfR 1 and TfR 2 , are now known to exist . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By immuno histochemical study of biopsied liver samples , the expression of transferrin receptor 1 ( TfR 1 ) , which mediates cellular iron uptake by serum transferrin was increased . ^^^ Fe labeled transferrin incorporation ( but not transferrin non bound iron ( NTBI ) ) into the cells is also increased , suggesting that the increased TfR 1 is functional . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Thus , erythroblasts must modify the `` standard ' ' post transcriptional feedback regulation , balancing expression of ferritin ( Fer ; iron storage ) versus transferrin receptor ( TfR 1 ; iron uptake ) via specific mRNA binding of iron regulatory proteins ( IRPs ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this study , the regulation of transferrin receptor 1 ( TfR 1 ) mediated iron uptake by human hsp 27 was investigated in CCL 39 cells by overexpression of human hsp 27 and its dominant negative mutant ( hsp 27 3G ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor 1 ( TfR 1 ) and Ferroportin ( FPN ) expression was found on the placental syncytiotrophoblast ( STB ) and were polarised such that TfR 1 was on the apical maternal facing membrane and FPN was on the basal fetal facing membrane , consistent with unidirectional iron transport from mother to fetus . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Clinically relevant Streptococcus spp . were tested for their susceptibility towards human serum transferrin ( TR ) and lactoferrin ( LF ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Three murine monoclonal antibodies ( mAbs ) against the 61 residue amino terminal cytoplasmic tail of the human transferrin receptor ( TR ) have been produced by immunization of mice with recombinant human TR produced in a baculovirus expression system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Nuclear factors from HeLa cells were isolated by elution of DNA cellulose bound proteins with a double stranded synthetic oligonucleotide corresponding to the region from 34 to 79 of the human transferrin receptor ( TR ) gene promoter . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Wild type and mutant human transferrin receptors ( TR ) have been expressed in chicken embryo fibroblasts using a helper independent retroviral vector . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here , we show that transplanted signals from the low density lipoprotein receptor ( LDLR ) and cation independent mannose 6 phosphate receptor ( Man 6 PR ) promote rapid internalization of the transferrin receptor ( TR ) , directly establishing that recognition signals are interchangeable , self determined structural motifs and that signals from type 1 membrane proteins are active in a type 2 receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The promoter of the cellular transferrin receptor ( TR ) gene contains a DNA sequence which is similar to the AP 1 and AP 4 binding region in SV 40 which has been implicated in the control of the viral late promoter . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , no significant changes in the expression of the interleukin 2 receptor ( IL 2R ; CD 25 ) , transferrin receptor ( TR ; CD 71 ) or HLA DR were observed in terms of percentage positive lymphocytes or mean cell surface membrane fluorescence intensity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Receptors for epidermal growth factor ( EGFr ) and nerve growth factor ( NGFr ) were found in many cells in short term cultures , but the transferrin receptor ( Tr ) was found in only a few cells of 87HG 28 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The density of HLA DR , interleukin 2 , and transferrin receptors ( IL 2 R and TR , respectively ) on the surface of CD 3 and CD 8 positive cells was computed by a mathematical model based on fluorescence intensity vector analysis , adjusted for cell size , utilizing two color flow cytometry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Chimeric genes were constructed by exchanging the DNA segments that encode the cytoplasmic and anchor domains between the human influenza virus ( A / WSN / 33 ) neuraminidase ( NA ) and transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The markers studied were transferrin receptor ( TR ) , Ki 67 antigen , and epidermal growth factor receptor ( EGFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Conjugates of sulfamethoxazole ( SMX ) with human serum albumin ( HSA ) , transferrin ( TR ) , and poly ( L lysine ) ( PL , degrees of polymerization 16 and 430 ) have been prepared . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined the expression of transferrin receptor ( TR ) in transitional cell cancer ( TCC ) immunohistologically , to clarify its implication in tumor malignancy . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron transport crossing the cell membrane is mediated by the specific transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptor ( Tr ) was investigated by means of immunohistochemistry in 101 tumours of the human central and peripheral nervous system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cells were seeded sparsely in Dulbecco ' s Modified Eagles / Ham ' s F 12 medium ( 1 : 1 ; 5 : 5 ) ( DME / F12 degrees ) , containing epidermal growth factor ( EGF ; 1 ng / ml ) , insulin ( 1 ; 10 micrograms / ml ) , and transferrin ( Tr ; 5 micrograms / ml ) ( DME / F12 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An enzyme linked immunosorbent assay using specific monoclonal antibodies was used to measure circulating transferrin receptor ( TR ) in 87 patients with various hematologic malignancies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
With 18 patients afflicted with recently diagnosed , non leukemic stages of B and T cell lymphoma cytofluorimetric analysis was performed with peripheral blood lymphocytes ( PBL ) after 72 h in culture with and without phytohemagglutinin , using antibodies against the differentiation antigens CD 3 , CD 8 , CD 4 , CD 16 , CD 19 , CDw 14 , and the activation antigens interleukin 2 receptor ( IL 2R , CD 25 ) , HLA DR ( DR ) , CD 56 and transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The neoplastic lymphoid cells in 33 patients with chronic lymphocytic leukemia ( CLL ) , 1 case of prolymphocytic leukemia ( PLL ) , and 29 patients with various types of non Hodgkin ' s lymphoma ( NHL ) were examined for the expression of transferrin receptors ( TR ) using a panel of three anti TR monoclonal antibodies ( MAb ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TR ) is expressed in a proliferation dependent manner that requires transcriptional activation of its gene . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of the transferrin receptor ( TR ) was examined on murine trophoblast cells on days 6 , 8 and 10 of gestation , using a monoclonal antibody visualized by indirect immunofluorescence on cryostat sections of the implant site . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In parallel , cytofluorimetric analysis was done with PBL after 72 hours in culture with and without PHA , using antibodies against the differentiation antigens : CD 3 , CD 8 , CD 4 , CD 19 , and CDw 14 and the activation antigens : interleukin 2 ( IL 2 ) receptor ( IL 2R , CD 25 ) , human leukocyte antigen DR ( HLA DR ) , and transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Flow cytometric studies further support the view that IgG ATRAS impair transferrin receptor ( TR ) function by causing TR down modulation and degradation , even when the presence of DFO acts to promote increased cell surface TR expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Thirty specimens taken from 25 adenocarcinomas , 1 squamous cell carcinoma , 2 anaplastic carcinomas and 2 malignant lymphomas were studied for the presence of transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Three monoclonal antibodies ( mAb ) FG 1 / 5 , FG 1 / 6 and FG 2 / 12 , specific for the human transferrin receptor molecule ( TR ) , have been used to define epitopes on the TR molecule and to block natural killer lysis . ^^^ Our results confirm the role of TR as a one of the target structures in NK lysis and suggest that the epitope recognized by NK cells is close to but different from the transferrin binding site . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two novel proteins that bind specifically to the transferrin receptor ( TR ) promoter , have been isolated from HeLa cell nuclear extract using a combination of ion exchange and oligonucleotide affinity chromatography . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A presently undefined nuclear antigen recognized by the monoclonal antibody Ki 67 , and the transferrin receptor ( TR ) , both expressed by proliferating cells , were visualized in cryostat sections of 40 consecutive cases of primary breast cancer using a three step immunoperoxidase technique . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TR ) , the HLA DR antigen ( DR ) , and the antigen binding OKT 10 ( T 10 ) are present on activated lymphocyte populations . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The cytoplasmic domain of transferrin receptor ( TR ) is essential for endocytosis of this transmembrane protein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have produced a new rat IgG monoclonal antibody against the murine transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptors ( TR ) was not changed significantly . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The human transferrin receptor ( TR ) is a protein comprising 760 amino acid residues that spans the membrane once with its N terminus towards the cytoplasm . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An immunotoxin was constructed by linking a murine monoclonal antibody against the human transferrin receptor ( TR ) to the plant toxin , ricin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of cyclosporine A ( CsA ) on the mitogen induced expression of Interleukin 2 receptor ( IL2R ) and transferrin receptor ( TR ) was monitored using receptor specific monoclonal antibodies and flow cytometry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two color cytofluorescence studies measuring IL2R and transferrin receptor ( TR ) on day 2 of culture revealed that most of the increase in IL2R+ cells in response to L 4 was attributable to IL2R+TR cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We tested the premise that measurement of interleukin 2 receptor ( IL2R ) and transferrin receptor ( TR ) can be used to assess proliferative responses to pokeweed mitogen ( PWM ) and tetanus toxoid ( TT ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using a panel of monoclonal antibodies ( MoAbs ) , the frequency of cells bearing Class 1 and Class 2 major histocompatibility complex ( MHC ) determinants , transferrin receptor ( TR ) sites , and interleukin 2 receptors ( IL 2R ) has been evaluated on pulmonary alveolar macrophages ( PAM ) recovered from the bronchoalveolar lavage ( BAL ) fluid of 21 patients with pulmonary sarcoidosis ( including 11 cases with active sarcoidosis and 10 cases with inactive disease ) , 8 patients with hypersensitivity pneumonitis ( HP ) , and 6 normal non smoking volunteers . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In Chinese hamster ovary ( CHO ) fibroblast cells the protein kinase C activating phorbol ester , phorbol myristate acetate ( PMA ) , stimulates an increase in cell surface transferrin receptor ( TR ) expression by increasing the exocytic rate of the recycling pathway . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of this investigation was to further study the profiles of serum iron ( Se Fe ) and transferrin ( Se Tr ) , in 14 physically trained men ( 28 + / 6 years ) during an exhaustive interval training session . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have investigated the role of phosphorylation in the endocytosis of the human transferrin receptor ( TR ) by replacing its phosphorylation site , Ser 24 , with Ala through site directed mutagenesis of the TR cDNA . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect on Escherichia coli strain B 117 of bovine lactoferrin ( LF ) , transferrin ( Tr ) and immunoglobulins ( Ig ) , acting alone or in combination , was investigated in vitro . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Frozen sections of NHL were reacted with an antibody to the transferrin receptor ( TR ) and Ki 67 as markers for proliferative activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( TR ) mediates cellular iron uptake by bringing about the endocytosis of transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin is an iron carrying compound that stimulates cell growth and division by binding to specific receptors ( TR ) which are preferentially expressed by actively growing cells or by the malignant counterpart of normal cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The method described here is of general application for coupling primary aromatic amines to the carrier proteins and circumvents many of the problems inherent in the isocyanate or diazocoupling methods . 3 Azido N ethylcarbazole ( ANEC ) , the azido analog of 3 amino N ethylcarbazole , was conjugated to bovine serum albumin ( BSA ) , human transferrin ( TR ) , thyroglobulin ( TH ) , poly ( lysine 10 tyrosine ) , and poly ( lysine 10 phenylalanine ) using standard photolabeling procedures . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Each subunit of the human transferrin receptor ( TR ) dimer is inserted into the ER membrane as a transmembrane polypeptide having its N terminus in the cytoplasm . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The degree of surface expression of transferrin receptor ( TR ) was only in part correlated with that of cell lysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Anion binding was described by two equilibrium constants for the successive binding of two anions per transferrin molecule : K 1 = [ A Tr ] / [ A ] [ Tr ] and K 2 = [ A Tr A ] / [ A ] [ A Tr ] where [ A ] represents the free anion concentration , [ Tr ] represents apotransferrin concentration , and [ A Tr ] and [ A Tr A ] represent the concentrations of 1 : 1 and 2 : 1 anion transferrin complexes , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The level of albumin ( Al ) , transferrin ( Tr ) , alpha 1AT and Hp was inversely proportional to the amount of liver cell necrosis , Particularly , Hp showed a marked decrease in submassive or massive necrosis , while a moderate decrease in minimal change of focal necrosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The distribution of transferrin receptors ( TR ) has been studied in a range of normal and malignant tissues using four monoclonal antibodies , BK19 . 9 , B3 / 25 , T56 / 14 and T58 / 1 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A cDNA clone bank containing 30 000 clones was constructed from sucrose gradient fractionated mRNA from human placenta . mRNA coding for transferrin receptor ( TR ) was enriched by polysome immuno adsorbed chromatography with monospecific rabbit IgG and protein A Sepharose . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Bovine serum albumin and transferrin ( Tr ) milk levels rose and fell simultaneously , whereas the increase in lactoferrin ( LF ) levels , which occurred only when acute mastitis developed ( two of the three infections ) , was delayed . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Bacterial ability to obtain iron in bovine serum or in media containing transferrin ( Tr ) or conalbumin ( Ca ) was investigated by using serum resistant ( virulent ) and serum sensitive ( avirulent ) strains of Escherichia coli and Salmonella typhimurium . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Albumin ( Alb ) and transferrin ( Tr ) were not different in patients with or without sepsis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Reports that the genes for the transferrin receptor ( TR ) and possibly transferrin are located on chromosome 3 prompted us to investigate the chromosomal localization of the p 97 gene . ^^^ We conclude that the p 97 gene , like the transferrin and TR genes , is located on chromosome 3 . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In 30 men and 29 women the mean gingival exudate ratio alpha 1 antitrypsin ( A1AT ) / transferrin ( Tr ) was higher than the mean blood ratio for A1AT / Tr , when determined by double electroimmunoassay . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A 20 day old human conceptus was studied by the indirect immunoperoxidase technique for the presence of a series of plasma proteins : prealbumin ( PA ) , albumin ( ALB ) , alpha fetoprotein ( AFP ) , alpha 1 antitrypsin ( A1AT ) , carcioembryonic antigen ( CEA ) , immunoglobulin G ( IgG ) , ferritin ( FER ) , transferrin ( TR ) , fetal haemoglobin ( HbF ) , human chorionic gonadotropin ( HCG ) , human placental lactogen ( HPL ) and pregnancy specific beta 1 glycoprotein ( SP 1 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Primary cultures of rat ventral prostate epithelial cells were grown in 24 well culture vessels containing F12K culture medium supplemented with various concentrations of the following substances : fetal bovine serum ( FBS ) , horse serum ( HS ) , testosterone ( T ) , dihydrotestosterone ( DHT ) , hydrocortisone ( HC ) , zinc ( Zn ) , transferrin ( TR ) , cysteine ( CYS ) , glutamine ( GLT ) , selenium ( SEL ) , and ascorbic acid ( AC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Animal and clinical studies were performed in order to establish a criterion for diagnosis of iron deficiency anemia and a standard dose of the intravenous iron treatment , based on properties of serum transferrin ( Tr ) in ironmetabolism during gestation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two colour flow cytometric analysis of lymphocytes revealed that none of the drugs affected cell surface activation molecule expression ( CD 25 = IL 2R 55 kD alpha chain , HLA DR or CD 71 = transferrin receptor [ TR ] ) on allostimulated CD4+ or CD8+ cells harvested at three days of culture . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The antibody competes with the transferrin receptor ( TR ) for binding to human Tf and is therefore expected to bind at or very close to a region of interaction between Tf and its receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Nine of the 13 proteins were found in all types of stone : human serum albumin ( HSA ) , alpha 1 acid glycoprotein ( alpha 1 GP ) , alpha 1 microglobulin ( alpha 1 M ) , immunoglobulins ( Igs ) , apolipoprotein A 1 ( apo A 1 ) , transferrin ( Tr ) , alpha 1 antitrypsin ( alpha 1 T ) , retinol binding protein ( RBP ) and renal lithostathine ( RL ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Immunocytochemistry , immunohistochemistry , immunobead binding , immunofluorescence , 125iodine transferrin binding , and Northern blot analysis were used to compare TR expression in DAOY cells in vitro and in vivo . ^^^ Using a transferrin toxin conjugate in a nude rat model of leptomeningeal carcinomatosis , we achieved therapeutic efficacy , despite demonstrating reduced TR expression on tumor tissue . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study , we characterized the properties of intercompartmental boundaries by tagging transferrin receptor ( TR ) with either 210 nm phi latex or 40 nm phi colloidal gold particles , and by dragging the particle TR complexes laterally along the plasma membrane using laser tweezers . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Our objective was to determine the role of increased glomerular clearance ( GC ) or reduced tubular reabsorption ( TR ) of transferrin in producing microtransferrinuria . ^^^ An infusion of L arginine was used to inhibit TR of transferrin , permitting the determination of both GC and TR of transferrin in 64 patients with non insulin dependent diabetes mellitus ( NIDDM ) , with or without microtransferrinuria . ^^^ However , the TR of transferrin was inversely correlated with TfER in healthy controls and in the NIDDM patients , with or without microtransferrinuria . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To investigate potential sorting signals in the cytoplasmic tail of APP , we transplanted APP cytoplasmic tail sequences into the cytoplasmic tail of the human transferrin receptor ( TR ) and showed that two sequence motifs from the APP cytoplasmic tail promote TR internalization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To study the effect of increased fetal iron demand on placental transferrin receptor ( TR ) , we utilized a monoclonal antibody to localize placental TR immunoreactivity and 125I labeled transferrin to study TR binding characteristics in 10 placentas from poorly controlled diabetic mothers with increased fetal iron demand and 10 placentas from nondiabetic mothers . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have previously described purification and characterization of a nuclear protein , TREF , which interacts specifically with the transcriptional control element , TRA , of the human transferrin receptor ( TR ) gene . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The percent and composition of T lymphocyte subsets were studied along with the ability to generate interleukin 1 ( Il 1 ) and interleukin 2 ( Il 2 ) as well as spontaneous and PHA stimulated expression of receptors for Il 2 ( TAC ) and transferrin receptor ( Tr ) on lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In polarized MDCK cells influenza virus ( A / WSN / 33 ) neuraminidase ( NA ) and human transferrin receptor ( TR ) , type 2 glycoproteins , when expressed from cloned cDNAs , were transported and accumulated preferentially on the apical and basolateral surfaces , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression and extracellular release of transferrin receptor ( TR ) was investigated by in vitro model system of erythroid differentiation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The concentrations which produced 50 % inhibition of lipid peroxidation ( IC 50 ) by theaflavin ( TF ) , theaflavin monogallate A ( TFM A ) , and TR were 4 . 88 10 10 ( 4 ) , 4 . 09 10 10 ( 4 ) , and 4 . 95 10 10 ( 4 % ) ( w / v ) , respectively . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The signal anchor domains of neuraminidase ( NA ) , asialoglycoprotein receptor ( ASGPR ) and transferrin receptor ( TR ) all yielded biologically active type 2 derivatives of the 5 sis oncoprotein . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This method was used to measure mRNA for the vitamin D binding protein ( Gc ) , beta actin and the transferrin receptor ( TR ) gene in the Hep3B cell line . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A rapid method for detecting the presence of transferrin receptors ( TR ) on human glioblastoma derived cell lines is presented . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
By functional analysis of mutant human transferrin receptors ( TR ) expressed in chicken embryo fibroblasts , we previously identified a tetrapeptide sequence , Y20TRF23 , within the 61 residue cytoplasmic tail as the signal for high efficiency endocytosis ( Collawn , J . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Peripheral blood CD3+ , DR+ , CD3+DR+ , CD4+ , CD4+DR+ , CD8+ , CD8+DR+ , CD56+ , CD8+CD56+ , CD3+IL 2 R+ and CD3+TR+ ( interleukin 2 and transferrin receptors bearing CD3+ cells respectively ) , all mononuclear cells expressing IL 2 R and TR , and CD4+CD45+ cell subsets were analyzed and enumerated by 2 color flow cytometry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Patients were referred for upper abdominal studies including portal vein assessment . 40 patients were imaged in the coronal plane using a multislice TurboFLASH ( TF ) sequence ( TR = 100 ; TE = 4 ) acquired during a breath hold period of 19 s . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TR ) performs the major function of binding and internalizing its specific iron loaded ligand , transferrin , and its expression is closely linked to the proliferation status of the cell . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Because HuH 7 cells also acquire iron from transferrin by a receptor ( TR ) mediated process , TR expression was inhibited by transfecting the cells with a plasmid containing human TR complementary DNA in antisense orientation relative to a human cytomegalovirus promoter / enhancer element . ^^^ Cell clones were obtained that expressed a 50 % to 60 % reduction in cell surface TR , leading to a corresponding decrease in transferrin and iron uptake compared with wild type cells . ^^^ The amounts of transferrin taken up by the wild type and antisense cells by this process were similar , showing that it did not involve TR . ^^^ This process , like the TR mediated one , involved the internalization and recycling of transferrin , leading to accumulation of iron with time . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To characterize the trafficking motifs contained in the carboxyl terminus of GLUT 4 , a chimera ( GTCTR ) was constructed in which the carboxyl terminal 30 amino acids of GLUT 4 were substituted for the amino terminal cytoplasmic domain of the transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The distributions of MTf , Tf and the TR were studied immunohistochemically in human brain tissues . ^^^ The distributions of MTf and TR were remarkably similar , and quite different from that of Tf . ^^^ In all brain tissues examined , MTf and the TR were highly localized to capillary endothelium , while Tf itself was mainly localized to glial cells . ^^^ One method of iron transport across the blood brain barrier ( BBB ) involves the transferrin receptor ( TR ) , which is localized to the specialized brain capillary endothelium . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of distinct antigens displayed on a subpopulation of cord RBC and detected by anticord RBC membrane antibodies was particularly investigated , concomitantly with the presence of transferrin receptors ( TR ) by employing immunohistochemistry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TR ) expression by blast cells in 127 cases of acute lymphoblastic leukemia ( ALL ) at presentation and 19 cases at relapse was examined using three anti TR monoclonal antibodies to find its correlation with prognostic features such as the total leucocyte count ( TLC ) , the morphology of blast cells and their cytochemical and immunophenotypic properties , as well as age and sex of the patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
MRCP was performed with a superconductive magnet at 0 . 5 T , with volumetric images on coronal planes acquired using an IR turbo SE sequence ( TR 2500 , TE 1000 , TF 89 , 4 NEX ) with respiratory triggering and vascular presaturation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To create a system for studying this pathway , we replaced the native transferrin receptor ( TR ) internalization motif ( YTRF ) with the SDYQRL TGN targeting motif . ^^^ The advantages of using TR as a reporter molecule include the ability to monitor trafficking , in both biochemical and microscopy experiments , using the natural ligand transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Plasma proteins ( prealbumin , PA ; albumin , Alb ; transferrin , Tr ; retinol binding protein , RBP ) and acute phase reactant proteins ( alpha 1 acid glycoprotein , AGP ; C reactive protein , CRP ; ceruloplasmin , CER ) were measured by radial immunodiffusion . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In polarized Madin Darby canine kidney ( MDCK ) cells , the transferrin receptor ( TR ) is selectively delivered to the basolateral surface , where it internalizes transferrin via clathrin coated pits and recycles back to the basolateral border . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study was undertaken to determine the following : 1 ) the kinetic changes responsible for the depletion and repletion of plasma transferrin ( Tr ) concentration in children with protein energy malnutrition ( PEM ) ; 2 ) the role of infection in mediating these changes ; and 3 ) whether plasma Tr concentration is related to body protein status . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Iron status of 1 , 861 Filipino infants and preschoolers was evaluated by measurements of plasma ferritin ( PF ) , transferrin receptor ( TR ) and hemoglobin ( Hb ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The aim of the present work was to verify the effects of insulin ( 1 ) and transferrin ( Tr ) , two hormones considered as essential in other serum free culture systems , and three androgenic hormones , since the prostate is known to be androgen dependent . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The liver acquires iron from transferrin by transferrin receptor mediated ( TR ) and transferrin receptor independent pathways ( NTR ) and from nontransferrin bound iron ( NTB Fe ) . ^^^ Experiments , using human hepatoma cells ( HuH 7 ) transfected with TR antisense ( sense for control ) RNA expression vectors to suppress TR expression , were performed to examine the effect of unlabeled NTB Fe as iron citrate on the uptake of 59Fe 125I transferrin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Lf R and transferrin receptors ( Tr R / CD71 ) show the same kinetics of appearance on activated blood lymphocytes and are , to a large extent , expressed on the same cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We have investigated the intracellular trafficking of a chimeric molecule consisting of the cytoplasmic domain of the beta amyloid precursor protein ( APP ) and the transmembrane region and external domain of the human transferrin receptor ( TR ) in Madin Darby canine kidney cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Human transferrin receptors ( TR ) and receptors for polymeric immunoglobulins ( pIgR ) expressed in polarized MDCK cells maintain steady state , asymmetric distributions on the separate basolateral and apical surfaces even though they are trafficking continuously into and across these cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To determine how lysosomal and internalization signals differ , we prepared chimeric molecules consisting of the cytoplasmic tails of CD 3 gamma chain , lysosomal acid phosphatase , and lysosomal associated membrane glycoprotein 1 , each fused to the transmembrane and extracellular domains of the transferrin receptor ( TR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In order to characterize the mechanism by which Iron ( Fe ) is taken up by neurons , we examined the neuronal expression of transferrin receptor ( TR ) in rats during development and iron ( Fe ) deficiency by using immunohistochemistry , in vitro receptor autoradiography and in situ hybridization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
At 20 degreesC dIgA pIgR internalize to interconnected groups of vacuoles and tubules that comprise the endosomal compartment and in which they codistribute with internalized transferrin receptors ( TR ) and epidermal growth factor receptors ( EGFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The effect of protein kinase inhibitors on transferrin receptor ( TR ) internalization was examined in HeLa , A 431 , 3T3 L 1 cells , and primary chicken embryo fibroblasts . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In previous studies , we demonstrated that substitutions in the transferrin receptor ( TR ) transmembrane domain ( TM ) convert the protein from an efficiently recycling receptor to one that is rapidly down regulated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We show that proteins specific to the early endocytic pathway , EEA 1 and transferrin receptor ( TR ) , are present on early SCVs . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The present study was planned to detect the iron binding protein , transferrin ( TR ) in paraffin sections of the human breast tumors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study investigated the inhibition of cyclophosphamide ( CP ) and dimethylbenz ( a ) anthracene ( DMBA ) induced genetic damage by black tea ( World blend ) and its two active polyphenols theaflavins ( TF ) and thearubigins ( TR ) in Swiss albino mice as measured by chromosome aberrations ( CA ) and sister chromatid exchanges ( SCE ) . ^^^ Three different concentrations ( 5 , 10 and 20 % ) of tea and a single dose of TF and TR were tested for their anticlastogenic effects against DMBA ( 50 mg / kg body weight ) and CP ( 20 mg / kg for CA and 10 mg / kg for SCE ) . ^^^ In the single dose of TF and TR treated groups a significant decrease in both CA and SCE was observed in both the TF and TR plus both the carcinogen treated groups when compared with their positive controls . ^^^ This study indicates that both black tea and its active polyphenols TF and TR have significant anticlastogenic effects in bone marrow cells of mice . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
CONCLUSION : The induction effects on TF and uPAR mRNA expression in both of the cultured cells by thrombin were mainly dependent on the TR activation , which may not be the unique pathway for thrombin to induce TF and uPAR mRNA expression in VEC . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The present study was planned to detect the iron binding protein , transferrin ( TR ) in paraffin sections of the human breast tumors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Blood transferrin receptor ( TR ) level is largely determined by the quantum of erythropoiesis and by intracellular iron content of the cells of the erythroid lineage . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The anticancer effect of black tea ( BT ) and its polyphenols theaflavin ( TF ) and thearubigin ( TR ) has been evaluated on U 937 cell line , a myeloid leukemic cell line and on leukemic cells isolated from peripheral blood of chronic myeloid leukemia ( CML ) patients . ^^^ In both types of cells , cell growth inhibition was observed 24 hrs after treatment with BT , TF and TR . ^^^ In all cases TF and TR were more effective than BT , suggesting that these are possibly the active components in BT responsible for its antileukemic activity . ^^^ Superoxide dismutase ( SOD ) , a free radical scavenger , was found to be increased by TF , whereas BT and TR lowered the level in comparison to the control . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition , we also made two chimeric NA by replacing the CT proximal one third amino acids of the NA TMD [ NA ( 1T2N ) NA ] and the entire NA TMD ( NATRNA ) with that of human transferrin receptor ( TR ) ( a type 2 transmembrane glycoprotein ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Differences between cultivars were observed in eight different black grape varieties : Touriga Brasileira ( TBR ) , Tinta Barroca ( TB ) , Tinta Amarela ( TA ) , Souzo ( S ) , Touriga Franca ( TF ) , Touriga Nacional ( TN ) , Tinta Roriz ( TR ) , and Tinto Co ( TC ) , from the Douro region . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NHANES 3 total femur ( TF ) conversions for GE Lunar ( GE ) have previously been available , and femoral neck ( FN ) and trochanter ( TR ) equations were reported recently . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : 1300 women living in Tien Shan areas were examined for serum and erythrocytic ferritins ( SF and EF ) , general iron binding capacity of the serum , transferrin saturation with iron , transferrin , soluble transferrin receptor ( TR ) , erythropoietin ( EP ) , Hb , erythrocytes , erythrocytic indices . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study investigated the antimutagenic and anticlastogenic effects of black tea polyphenols , theaflavins ( TF ) and thearubigins ( TR ) in Salmonella assay in vitro and in vivo in bone marrow cells of mice as measured by chromosomal aberrations ( CA ) and sister chromatid exchange ( SCE ) against a known carcinogen , benzo [ a ] pyrene ( B [ a ] P ) . ^^^ A significant decrease in mutagenicity in Salmonella assay and both CA and SCE were observed in all the different concentrations of TF and TR plus B [ a ] P treated series when compared with B [ a ] P treated group alone . ^^^ These results indicate that both TF and TR have significant antimutagenic and anticlastogenic effects . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
It contains dimeric flavanols and polymeric polyphenols known as theaflavins ( TF ) and thearubigins ( TR ) . ^^^ On the basis of our previous potent antimutagenic and anticlastogenic effects of TF and TR in vitro in bacterial system and in vivo in mouse bone marrow cells , we have decided to extend our study in human cells in vitro . ^^^ This study investigated the anticlastogenic effects of black tea polyphenols TF and TR as measured by chromosomal aberrations ( CA ) and micronuclei formation ( MN ) against two known mutagens / carcinogens i . e . benzo [ a ] pyerne ( B [ a ] P ) and aflatoxin B 1 ( AFB 1 ) with S 9 activation . ^^^ A significant decrease in both CA and MN were observed in the human lymphocyte cultures treated with either TF or TR pretreated with either B [ a ] P or AFB 1 ( 250 , 500 , 1000 microg / ml ) when compared with B [ a ] P or AFB 1 treated cultures alone . ^^^ TF shows more protective effects than TR in this in vitro system . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of the transferrin receptor ( TrfR ) in tumor cells was compared with histopathologic prognostic factors , such as TNM factors , degree of histologic differentiation , degree of nuclear atypia , and frequency of mitotic figures . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These results were compared with transferrin receptor ( TrfR ) expression , estrogen receptor ( ER ) status , histologic type , tumor grade , size and axillary lymph node status . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Prognostic significance of immunohistochemical parameters in breast carcinomas . 136 breast carcinomas were investigated immunohistochemically for alpha lactalbumin ( ALA ) , lactoferrin ( Lfr ) , human milk fat globule membrane antigen ( HMFG 2 ) , transferrin receptor ( TrfR ) , Ki 67 and epidermal growth factor receptor ( EGFR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TRFr ) expression by cells in mixed lymphocyte culture increases steadily for the first 5 days , but then reaches a plateau . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TrfR ) expression in breast carcinoma and its possible relationship to prognosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Only IL 2 and IL 4 induced a marked stimulation of [ 3H ] thymidine ( [ 3H ] TdR ) uptake , cell proliferation and expression of activation markers [ transferrin receptor ( TrfR ) , IL 2R ] . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These results were compared with growth fractions ( Ki 67 immunoreactivity and Transferrin receptor ( TrfR ) expression ) , histologic tumor type , tumor grading , axillary lymph node status and estrogen receptor ( ER ) status . 60 . 2 % were EGFR positive . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The concentration of leukocytes , lymphocytes , monocytes and granulocytes and T 4 ( T helper ) , T 8 ( T suppressor / cytotoxic ) , interleukin 2 receptor ( IL 2R ) and transferrin receptor ( TrfR ) positive lymphocytes were determined both in peripheral blood and spleen by flow cytometric analysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An increase in the number of epidermal growth factor and transferrin receptors ( EGFR , TrfR ) is induced by Ara C on these cells . ^^^ Two classes of EGF binding sites with a Kd of 0 . 055 nM and 2 . 3 nM respectively , and one class of transferrin binding sites with a Kd of about 4 nM are detected on both untreated and Ara C treated KB cells . [ 3H ] Thymidine uptake is clearly stimulated on KB cells by nanomolar concentrations of EGF and transferrin , whereas in Ara C treated cells [ 3H ] thymidine uptake is not increased by EGF and transferrin under conditions where maximal EGFR and TrfR up regulation occurs . ^^^ The enhanced EGF and transferrin binding is paralleled by a twofold increase of in vitro targeting of Ara C treated KB and A 549 cells with anti EGFR 108 . 1 mAb and anti TrfR OKT 9 mAb . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Smear preparations were made from cells harvested from pleural fluid from 90 patients with breast cancer and stained for transferrin receptor ( TRFr ) and insulin like growth factor 1 receptor ( IGF Ir ) using an immunocytochemical technique . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The plasmid DNA is packaged within the interior of polyethylene glycol modified ( PEGylated ) immunoliposomes , and delivered to the brain tumor with MAbs that target the mouse transferrin receptor ( TRFR ) and the human insulin receptor ( INSR ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Four genes involved in iron homeostasis were included in the 50 differentially expressed genes [ hemochromatosis ( Hfe ) , diaphorase 1 , transferrin receptor ( Trfr ) 2 , and protoporphyrinogen oxidase ] and two additional iron related genes did not quite meet the stringent criteria for differential expression ( Trfr and lactotransferrin ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Interestingly , FK 506 did not affect the expression of activation antigens such as CD 23 , IL 2 receptor ( CD 25 ) , and transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( CD 71 ) was expressed by some stromal macrophages , by seminiferous tubules , and by Leydig cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Mononuclear cells obtained by density gradient cytocentrifugation were stained with monoclonal fluorescein conjugated antibodies detecting CD 4 ( T helper ) , CD 8 ( T suppressor ) , CD 25 ( Interleukin 2 receptor ) , and the CD 71 ( Transferrin receptor ) antigens . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Other B cell differentiation antigens ; HLA DR , CD 19 , and transferrin receptor ( CD 71 ) , did not demonstrate significant changes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On Day 2 we observed a reduced proportion of transferrin receptor ( CD 71 ) positive CD 4 OX44 cells , representing the cycling immature CD 4 CD8+ cells , and of CD71+OX44 cells , representing the cycling CD4+CD8+ cells , but not of CD71+CD4 CD 8 cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , the glycoproteins CD18 / 11a , b , c ( leukocyte integrins ) , CD 71 ( transferrin receptor ) , HLA class 1 , and 8A3 Ag , which contain N linked glycans but no O sialo glycans , were resistant to the action of the enzyme . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the presence of interleukin 3 ( IL 3 ) , IL 6 , erythropoietin , and mast cell growth factor ( a c kit ligand ) , cell numbers increased approximately 10 ( 6 ) fold over a period of 4 wk , and the percentage of cells that expressed transferrin receptors ( CD 71 ) increased from less than 0 . 1 % at day 0 to greater than 99 % at day 14 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Identification of CD 71 ( transferrin receptor ) expressing erythrocytes by multiparameter flow cytometry ( MP FCM ) : correlation to the quantitation of reticulocytes as determined by conventional microscopy and by MP FCM using a RNA staining dye . ^^^ Reticulocytes express the CD 71 defined antigen , the transferrin receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , markers for cycling cells , interleukin 2 ( CD 25 , 13 + / 6 % ) and transferrin ( CD 71 , 23 + / 14 % ) receptors , were frequent in the specimens studied . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The ontogeny of HLA Dr and transferrin receptor ( CD 71 ) expression in response to anti CD 3 stimulation is similar among the groups , but is distinct from that of ConA proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , it appeared that SA may act selectively to inhibit expression of transferrin receptors ( CD 71 ) , a T cell activation antigen . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These CD3+ TcR gamma / delta T cells expressed the CD 25 ( IL 2 receptor ) , CD 38 , CD 71 ( transferrin receptor ) and HLA DR activation antigens at a higher intensity after in vitro stimulation with recombinant IL 2 , phytohemagglutinin and soluble egg antigen ( from Schistosoma haematobium ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The kinetics of expression of CR3 / CD11b were parallel to that of CD 23 , but the expression of the transferrin receptor ( CD 71 ) remained negative . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In contrast , the very high purity AHF reduced the induced expression of two early T cell activation molecules : CD 25 ( interleukin 2 receptor ) and CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Consistently there was increased expression by macrophages of CD 14 , ICAM 1 ( CD 54 ) , Fc gamma RI ( CD 64 ) , Fc gamma RII ( CDw 32 ) , Fc gamma RIII ( CD 16 ) , transferrin receptors ( CD 71 ) and tissue factor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
They also expressed the CD 20 , CD 71 ( transferrin receptor ) as surface antigens . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The latter , however , caused no major alterations in the expression of leukocyte common antigen ( ICA ; CD 45 ) and transferrin receptor ( CD 71 ) in the cell lines examined . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Of those antigens not present on monocyte , the low affinity Fc receptor ( CD 16 ) , the alpha chain of the vitronectin receptor ( CD 51 ) , gp 65 MAX . 1 , and gp 68 MAX . 3 were expressed only upon serum induced macrophage differentiation , whereas the transferrin receptor ( CD 71 ) , MAX . 26 , and to some degree also gp 65 MAX . 11 appeared to be independent of maturation and were also found on primary cultures of adherent monocytes under serum free conditions . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Some of the hybrids expressed the human differentiation antigens CD 4 , CD 7 , CD 33 , and CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After incubation with murabutide , a larger number of lymphocytes expressed Ta 1 antigen ( CD W 26 ) and transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
With regard both to up regulation in response to different stimuli and to kinetics , CD 40 expression paralleled that of the early activation antigen CD 23 , whereas CD 43 was induced in parallel with the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although these results suggest a phenotype of activated B cells , the CD77+ cells are negative for the classical activation antigens : CD 23 ( the low affinity Fc receptor for IgE ) , CD 25 [ the interleukin ( IL ) 2 receptor alpha chain ] and CD 71 ( the transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Only a small fraction of PB CD34+ cells expressed CD 71 ( transferrin receptors ) ( 17 % ) while 94 % of BM CD34+ expressed CD71+ . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We also found that Leu 7 ( CD 57 ) + cells display CD 69 , a phenotypic marker of very early cell activation , but do not display three other markers of cell activation : CD 25 [ interleukin 2 ( IL 2 ) receptor ] , CD 71 ( transferrin receptor ) , and DR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To further investigate the activation process during lectin stimulation , aged peripheral blood mononuclear cells ( PBMC ) were stimulated with phytohemagglutinin ( PHA ) and assessed for CD 25 ( IL 2 receptor ) and CD 71 ( transferrin receptor ) expression at different intervals of time . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , following stimulation with Me 1811 , clone 103 showed increased surface expression of CD 25 ( IL 2 receptor ) and CD 71 ( transferrin receptor ) and produced significant amounts of IL 2 and IFN gamma . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To assess whether an abnormality in transferrin receptor expression or regulation could represent an underlying metabolic defect in the reticuloendothelial ( RE ) system in hemochromatosis , monocytes were analyzed for the expression of the transferrin receptor using a monoclonal antibody ( Act 2 ) to the transferrin receptor ( CD 71 ) and flow cytometric analysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These tumors which include most peripheral T cell lymphomas , cutaneous T cell lymphomas , and HTLV 1 associated adult T cell leukemias / lymphomas express antigens induced on activated T cells , including IL 2 and transferrin receptors ( CD 25 and CD 71 , respectively ) , as well as HLA DR . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After platelet allotransfusion , we found a characteristic increase in the expression of interleukin 2 receptor , dipeptydilpeptidase 4 ( CD 26 ) , activation inducer molecule ( AIM , CD 69 ) and transferrin receptors ( CD 71 ) on day 3 indicating that important functional molecules expressed on the activation of lymphocytes by allogeneic platelets . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Tumor cells of 14 cases of non Hodgkin lymphomas and 2 cases of Hodgkin disease were tested for the presence of the transferrin receptor ( CD 71 ) by flow cytofluorimetry before 67gallium imaging . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A new monoclonal antibody TR 19 ( IgG2a ) directed to the human transferrin receptor ( CD 71 ) was prepared after immunization of BALB / c mice with human non T , non B ALL cell line REH 6 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Although , CD25+ interleukin 2 ( IL 2 ) receptors were present on leukemic T cells of both patient , OKT9+ ( CD 71 ) transferrin receptors and OKT 10 ( CD 38 ) activation antigens were found only on Patient 2 ' s cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Synovial lining cells express numerous macrophage associated antigens , including CD11b ( CR 3 ) , CD 13 , CD 14 , CD 16 ( FcRIII ) , CD 18 , CD 32 ( FcRII ) , CD 45 ( leucocyte common antigen ) , CD 54 ( ICAM 1 ) , CD 64 ( FcRI ) , CD 68 , and CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using serial frozen sections , monoclonal antibodies and an indirect immunoperoxidase method , 13 fibroadenomas ( FA ) and 3 cystosarcomas phyllodes ( CSP ) were analyzed for the expression of Egp 34 , HEA 319 antigen , leucocyte differentiation antigens CD 10 , CD 30 , CD 57 , CD 72 , CDw 75 , and CD 77 , epidermal growth factor receptor ( EGFR ) , estrogen ( ER ) and progesterone receptor ( PR ) , and transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , numbers of blood borne HLA DR , IL 2 R and transferrin receptor ( CD 71 ) positive lymphocytes were unaffected by Cy A therapy , nor were any differences detected between psoriatic patients and normal controls using these cell markers . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Osteoclasts expressed a restricted range of macrophage associated antigens including CD 13 , CD15A , CD 44 , CD 45 , CD 54 , ( ICAM 1 ) , CD 71 ( transferrin receptor ) , and CD 68 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Here we show that PAL M 1 is directed against the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After decoding and clustering , the antibodies with this thymus labelling were in various clusters including those detecting early activation antigens ( CD 69 , Activation Inducer Molecule ) and intermediate activation antigens ( CD 25 , interleukin 2 receptor : CD 30 , Ki 1 group : CDw 70 , Ki 24 group : and CD 71 , transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Coexpression studies of CD45RA and CD 71 ( transferrin receptor ) expression on CD34+ cells defined a CD45RA CD71+ population containing 89 + / 6 . 3 % ( n = 4 ) BFU E and a CD45RA+ CD71+ population that contained all CFU GM ( n = 4 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To simplify the selection method , we took advantage of the expression of the transferrin receptor ( CD 71 ) by proliferating committed progenitors and the lack of CD 71 on noncycling immature progenitors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , FOM inhibited the expressions of IL 2 receptor ( CD 25 ) and transferrin receptor ( CD 71 ) on the activated T cell surfaces . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After an additional 16 24 h of culturing in the absence or presence of epithelial cells , T cells expressed increased levels of both the alpha chain of the interleukin 2 receptor ( IL 2R , CD 25 ) and the transferrin receptor ( CD 71 ) , both markers of T cell activation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A simultaneous three color FCM method was developed , with the basis that transferrin receptor ( CD 71 ) or glycophorin A ( glyco A ) is present on all immature red cells , but is not expressed on CD 45 positive leukocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cell activation was further analyzed using antibodies against interleukin 2 ( IL 2 ) receptors ( CD 25 ) , transferrin receptors ( CD 71 ) or HLA DR molecules . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Either anti CD 26 mAb , together with anti CD 3 , caused a similar sequential up regulation of CD 69 , CD 25 ( IL 2R alpha ) , and CD 71 ( transferrin receptor ) expression on CD4+ and CD8+ T cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Interestingly , FOM did not affect the expression of activation antigens such as the CD 25 ( interleukin 2 receptor ) and CD 71 ( transferrin receptor ) antigens . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
All PB CD34+ cells express elevated levels of CD 71 ( transferrin receptor ) , with a subpopulation of high expressing cells , and CD 38 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Activation was not seen when cells were attached to the substrates using antibodies directed to other cell surface proteins including CD 71 ( transferrin receptor ) , CD 7 , and CD11a ( LFA 1 ) , demonstrating the specificity of activation for immobilized anti CD 3 antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
G CSF also enhanced expression of the transferrin receptor ( CD 71 ) on blast cells in vitro . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A significant proportion also expressed CD 71 ( transferrin receptor ) and MHC class 1 , although little if any CD 25 ( IL 2R p 55 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Using flow cytometry , we studied B cell LPL activation using the CD 71 ( transferrin receptor ) , CD 25 ( interleukin 2 receptor ) and 4F2 ( early B and T cell activation marker ) monoclonal antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
No correlation was found between cellular 67Ga uptake , ( micro ) dosimetry and transferrin receptor density ( CD 71 ) via which 67Ga enters the cell . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Surface markers on T lymphocytes ( CD 3 , CD 4 , CD 8 ) , B lymphocytes ( CD 19 ) and NK cells ( CD16 / 56 ) were normal in both groups ; however , in the acromegalic subjects , CD4+ and CD8+ cells showed a significant higher expression of transferrin receptors ( CD 71 ) , indicating enhanced T cell activity . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The role of transferrin receptor ( CD 71 ) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta aminolevulinic acid ( ALA ) . ^^^ Activated and proliferating cells respond to the demand for intracellular iron by upregulating membrane expression of the transferrin receptor ( CD 71 ) which is needed for iron uptake . ^^^ Activated lymphocytes expressing high levels of surface CD 71 transferrin receptors generated more PpIX than those with low CD 71 expression . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Fetal blood transferrin receptor ( CD 71 ) expression ( mean = 79 . 8 per cent , range = 60 98 per cent ) and nucleated red cell count ( mean = 10 . 4 10 10 ( 9 ) per 1 , range = 1 . 0 25 . 0 10 10 ( 9 ) per 1 ) were significantly higher than the appropriate normal mean for gestation ( z = 3 . 92 , P < 0 . 0001 and z = 3 . 69 , P < 0 . 001 , respectively ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On the surface of their dendritic extensions they express transferrin receptors ( CD 71 ) , the B cell epitope CD 20 , class 2 antigens , the myelomonocytic molecule CD 14 , the glycoprotein gp 50 ( CD 40 ) , and several receptors for components of the complement system ( CD11b , CD 21 , CD 35 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Flow cytometry was used as a quantification technique to measure lymphocyte subpopulations , CD 3 ( T cells ) , CD 19 ( B cells ) , CD 16 ( natural killer cells ) , CD 4 ( T helper / inducer cells ) , CD 8 ( T cytotoxic / suppressor cell ) , CD 25 ( interleukin 2 receptor ) , CD 69 ( activation inducer molecule marker ) , CD 71 ( transferrin receptor ) and CD 54 ( ICAM 1 ) ; CD4 / CD8 ratios were also estimated . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
RESULTS : Supernatant of PCI 50 promoted expression of the following activation markers on NK and T cells : CD 25 ( interleukin 2R alpha ) , HLA DR ( major histocompatibility complex class 2 ) , CD 54 ( ICAM 1 ) , CD 71 ( transferrin receptor ) , and CD 69 ( activation inducing molecule ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , the CD4 / CD8 ratio of BAL T lymphocytes correlated with the AM expression of CD 54 ( intercellular adhesion molecule 1 ( ICAM 1 ) ) , RFD 1 ( marker of dendritic cells ) , and CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
There was no correlation between the expression of ICAM 1 , LFA 3 and Transferrin receptor ( CD 71 ) and the conjugate formation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We studied the lymphocyte activation markers CD 25 ( interleukin 2 receptor ) , CD 38 , CDw49b ( VLA 2 ) , CD 71 ( transferrin receptor ) , and HLA DR , as well as the surface antigens CD 3 , CD 4 , CD 7 , and CD 8 by two color flow cytometry in 23 chronic HD patients before and after a single dialysis session ; we also studied 30 normal controls . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Proliferating cells require iron and , therefore , express the transferrin receptor ( CD 71 ) that mediates cellular iron uptake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of the transferrin receptor ( CD 71 ) increased 7 . 3 fold in cells treated with both agents , compared with untreated controls . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Dividing cells require iron and , therefore , express the transferrin receptor ( CD 71 ) on the cell surface to enable internalization of transferrin bound iron . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
MoAbs used were directed at myeloid ( CD11b , CD 13 , CD 14 , CD 15 , CD 33 , CD 41 ) , lymphoid ( CD 2 , CD 3 , CD 7 , CD 9 , CD 10 , CD 19 ) , or stem cell ( HLA DR , CD 34 , c kit receptor ) antigens , as well as the leukocyte integrins CD 18 and CD49e , and the transferrin receptor CD 71 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Paired daughter cells derived from BFU E have CD41a , CD41b , CD 71 ( transferrin receptor ) and HLA DR antigens , but not CD 34 or CD 33 antigen . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To confirm this hypothesis we investigated the T cell activation trend , evaluating the surface expression of IL 2 receptor ( CD 25 ) , transferrin ( CD 71 ) , HLA class 2 ( DR ) , and CD 69 phenotypes after in vitro stimulation with phytohemagglutinin ( PHA ; 1 and 10 micrograms / ml ) and concanavalin A ( 12 . 5 micrograms / ml ) in six newly diagnosed Type 1 diabetics and six islet cell and insulin autoantibody positive first degree relatives . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
BaP had little or no effect on the percentages of cells with induced IL 2 ( CD 25 ) or transferrin ( CD 71 ) receptors or on the amount of IL 2 activity present in 24 hr culture supernatants . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These were compared with the proportion of CD 4 CD45RO , IL 2R ( CD 25 ) , and transferrin receptor ( CD 71 ) positive peripheral blood lymphocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The Tf flu construct was taken up by the cells via the Tf receptor ( CD 71 ) as the binding of Tf flu was blocked by an excess of Tf . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( CD 71 ) expression on circulating mononuclear cells during pregnancy . ^^^ OBJECTIVE : We studied transferrin receptor ( CD 71 ) expression in peripheral blood mononuclear cells from healthy pregnant women , to determine if a relationship existed between gestational age and circulating CD71+ mononuclear cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of different surface antigens considered to reflect lymphocyte activation was variable ; the human lymphocyte antigen ( HLA ) DR , CD 25 ( alpha chain of the interleukin 2 receptor ) , and CD 71 ( transferrin receptor ) were displayed at low levels in both types of samples . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
CD4+ and CD8+ T cells , irrespective of their expression of the CD45RA molecule , were able to stimulate resting B cells to express transferrin receptor ( CD 71 ) and IL 2 receptor ( CD 25 ) up to 17 days after activation with immobilized anti CD 3 , although CD8+ but not CD4+ T cell subsets appeared to become less potent in stimulating resting B cells after 17 days of activation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To assess the clinical utility of assays for the plasmocyte activation antigen CD 38 ( T 10 ) and the thymocyte activation antigen CD 71 ( transferrin receptor ; T 9 ) in childhood acute lymphoblastic leukemia ( ALL ) , we reviewed the presenting features and clinical outcomes of 325 ALL patients treated on a single protocol at St Jude Children ' s Research Hospital . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The surface expression of CD 13 ( aminopeptidase N ) , CD 4 , CD 35 ( C3b receptor ) , CD 64 ( Fc gamma RI ) , CD 71 ( transferrin receptor ) and HLA Class 2 was not affected by probucol . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Monoclonal antibody ICO 92 against the transferrin receptor ( antigen CD 71 ) ] . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The kinetics of expression of CD11b were parallel to that of CD 23 , but the expression of the transferrin receptor ( CD 71 ) remained negative . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Neither staurosporine nor CGP 41 , 251 modulated TPA induced down regulation of transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , T 2 had no effect on expression of IL 2R or the transferrin receptor ( CD 71 ) , but inhibited production of a number of cytokines , including IL 2 and IFN gamma by activated T cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The cells expressed the HD associated surface antigens CD 30 and CD 15 as well as the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this report , erythropoiesis was examined in growth factor supplemented perfused cultures of bone marrow mononuclear cells ( BMMNC ) using flow cytometric analysis of the transferrin receptor ( CD 71 ) , glycophorin antigen expression occurred with time , Initially , fewer than 10 % of the cells were ( CD71++ , but by day 8 , 19 34 % of the cells were CD71++gly A . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
CD11a , b , c / CD18 , CD 54 , CD49d were selected for their involvement in cell adherence , and transferrin receptor ( CD 71 ) and low affinity IgE receptor ( CD 23 ) were selected as markers for activated cells . ^^^ Transferrin receptor ( CD 71 ) expression and low affinity receptor for IgE ( CD 23 ) expression were increased on monocyte only after incubation with LPS used as positive control . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
DTCs promoted differentiation associated changes that included the surface up regulation of beta 2 integrins ( CD11a c / CD18 ) , cell growth arrest concomitant with transferrin receptor ( CD 71 ) down modulation , induction of the nonspecific esterase enzyme , and a rapid drop in the mRNA levels of c myc . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Surprisingly , the number of CD3+ TL bearing the IL 2 receptor ( CD 25 ) and transferrin receptor ( CD 71 ) was not increased . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
About 42 + / 10 % thyroid derived T cells in GD , 33 + / 11 % in TA and 34 + / 13 % in NTG expressed the HLA DR molecule but not the interleukin 2 ( CD 25 ) or the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The activation state of the T cells was established by staining for the interleukin 2 ( IL 2 ) receptor ( CD 25 ) , HLA DR or the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We studied the origin of transferrin receptor ( CD 71 ) positive cells in blood from seven women pregnant with a male fetus in order to explore if fetal cells could be detected among them . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Tf Ga produced significant upregulation of the transferrin receptor ( CD 71 ) in T cells as determined by flow cytometric analysis and northern blot assay , but did not affect the percentage of CD3+ / CD71+ T cells after mitogen stimulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Further incubation of bilirubin treated PBMNC with irradiated B lymphoid Raji cells after removal of the extracellular bilirubin resulted in a dose dependent decrease of cytotoxic T lymphocyte ( CTL ) activity , DNA synthesis , and expression of Tac antigen ( CD 25 ) and transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , GST suppressed the expression of IL 2R ( CD 25 ) and transferrin receptor ( CD 71 ) on SA stimulated B cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
These included CD 71 ( anti transferrin receptor , MRC OX 26 , used for rosetting ) , Cdw 90 ( anti Thy 1 , MRC OX 7 ) , and the newly described MRC OX 82 ( reacting with myeloiid cells in peritoneal exudate ) , employed in FACS sorting . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The large majority of CD34+ cells were committed toward initial myeloid differentiation ( CD33+ , CD13+ ) and expressed the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition , some MNC became activated in a dose and time dependent fashion following whole body irradiation , as indicated by expression of CD 71 , the transferrin receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Lymphocytes T ( CD3+ ) were significantly higher in the CSF than in the peripheral blood as was the case with the T cells that expressed transferrin receptors ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
CD 71 was used to quantify the number of transferrin receptors and GLY A to identify erythroblasts . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Both early and short lived ( interleukin 2 receptor [ IL 2R ] , alpha chain CD 25 , and transferrin receptor CD 71 ) and late antigen ( HLA DR ) expression were investigated by flow cytometric analysis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of OX 1 ( CD 45 ) , a common leukocyte antigen , was significantly higher on AM as was the expression of CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The RNase gene was then fused with a DNA coding for an single chain antibody against the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Increased expression of TF was accompanied by increased stable expression of macrophage specific markers ( CD 71 , the mannose receptor , the scavenger receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Culturing cells in reduced concentrations of glutamine augmented the percentage of cells expressing CD 64 ( Fc receptor for IgG / FcgammaRI , P < 0 . 01 ) , CD11b ( complement receptor type 3 / CR3 , P < 0 . 001 ) and CD 71 ( transferrin receptor , P < 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A 30 % increase ( P < . 001 ) in lymphocytes expressing the transferrin receptor ( CD 71 ) and in monocytes ( CD 14 ) ( P < . 05 ) occurred within 4 weeks . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( CD 71 ) expression in peritoneal macrophages from fertile and infertile women with and without endometriosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , this response was modulated by a concomitant increase in serum levels of the potential IL 4 antagonist soluble IL 4 receptor alpha chain ( sIL4R alpha ) . ( 2 ) Even during leucopenia a subset of T lymphocytes derived from leucopenic patients expressed the activation markers CD 25 ( IL 2 receptor ) , CD 71 ( transferrin receptor ) and HLA DR . ( 3 ) Subsets of circulating CD4+ and CD8+ T lymphocytes could undergo clonogenic proliferation in vitro , and a majority of these clones secreted IL 4 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , CD 71 ( transferrin receptor ) is expressed at low levels on early stem cells and generally increases during haematopoietic progenitor cell proliferation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Delineation of erythropoiesis in normal and malignant bone marrow using monoclonal antibody AS E 1 directed against transferrin receptors ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The phenotypic characterization was selected to represent various biological functions such as adhesion , phagocytosis ( CD11b / CD18 , CD11c / CD18 , CD 16 ) , antigen presentation ( HLA DR , ICAM 1 ) , differentiation ( transferrin receptor , CD 71 ) , receptor for LPS ( CD 14 ) and initiation of the coagulation cascade ( Tissue factor , CD 142 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Photofrin significantly increased spleen cell expression of the receptor ( CD 71 ) for the iron transport protein transferrin by 72 h post injection but did not affect levels of a receptor ( CD 25 ) for the T cell growth factor interleukin 2 ( IL 2 ) or spleen cell responsiveness to rIL 2 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The induction of activation markers , like CD 25 and CD 122 IL 2 receptors and CD 71 transferrin receptor , was also comparable in pulsed and non pulsed cultures . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( CD 71 ) expression in peritoneal macrophages from fertile and infertile women with and without endometriosis . ^^^ This study investigates transferrin receptor expression ( CD 71 ) as a marker of hyperactivity in peritoneal macrophages of infertile patients with minimal to mild endometriosis ( group 1 , n = 25 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We previously described positive staining with these Ab of a highly transferrin receptor positive ( CD 71 ) cell type in the bone marrow of multiple myeloma patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Activated replicating lymphocytes have low intracellular iron levels , with corresponding increases in the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In addition , both CD4+ and CD8+ lymphocytes showed a lower expression of activation markers , interleukin 2 ( IL 2 ) receptor ( CD 25 ) and transferrin receptor ( CD 71 ) , which could be partially restored 6 months after PTX , but did not reach normal values . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
For the transferrin receptor ( CD 71 ) , this ratio was also almost always greater than 1 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The transferrin receptor ( CD 71 ) expression , 67Ga uptake and cell proliferation inhibition were the parameters measured . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
T cells treated for 48 h with immobilized anti CD 3 monoclonal antibody upregulated expression of the interleukin 2 receptor alpha chain ( CD 25 ) , transferrin receptor ( CD 71 ) , the apoptosis regulating Fas receptor ( CD 95 ) , contained a greater level of the anti apoptotic protein Bcl 2 and accumulated significantly more BPD MA than their unactivated counterparts . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
To investigate whether transferrin receptor ( CD 71 ) expression is affected by acute HIV 1 infection , three different lymphoid cell lines ( MT 4 , SUPT 1 , H 9 ) were infected with HIV 1 and tested for surface CD 71 expression after different incubation periods depending on cell survival after infection . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Coordinated CD 34 and CD 71 ( transferrin receptor ) expression , morphology , gamma globin transcription , and colony formation in methylcellulose were observed during the 14 day culture period . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Antibodies to the gamma chain of fetal hemoglobin and the transferrin receptor ( CD 71 ) are the most useful fetal cell identifying reagents . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Analysis of CD 71 ( transferrin receptor ) expression by FCM correlated with immunocytochemistry ( r=0 . 77 , p < 0 . 05 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We investigated the effects of acute injection of morphine into the rat mesencephalon periaqueductal gray ( PAG ) , on splenic natural killer ( NK ) cell and lymphocyte functions , interleukin 2 ( IL 2 ) production , expression of T cell ( CD 3 ) , T helper cell ( CD 4 ) , T suppressor cell ( CD 8 ) , and NK cell ( NKR P 1 ) surface markers , and expression of IL 2 ( CD 25 ) and transferrin ( CD 71 ) receptors . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The percentage of B cells in PBMC that expressed CD 71 , a transferrin receptor , was significantly greater in patients compared to controls , particularly , in patients who were seropositive for acetylcholine receptor specific antibodies . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Blood samples were centrifuged in a Ficoll Paque gradient , the mononuclear cell fraction was isolated and stained with fluorescent monoclonal antibodies against glycophorine A ( GPA + PE ) , transferrin ( CD 71 + FITC ) , and Hoechst 33342 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Phorbol 12 myristate 13 acetate and all trans retinoic acid , which induce differentiation in U 937 cells , up regulated CD11b ( MAC 1 alpha integrin ) and CD 82 and down regulated CD 71 ( transferrin receptor ) in a time and dose dependent manner . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Neither IFN gamma treatment nor VZV infection affected the expression of transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The studies revealed that the integrins CD11a , CD11b , CD 18 , CD49d , and CD 61 , as well as the additional adhesion receptors CD 54 , CD62L , and the transferrin receptor CD 71 were expressed on day 11 of gestation to various degrees on these embryonic cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Micronucleus frequencies were scored in the youngest fraction of reticulocytes : scoring by microscopy was restricted to the types 1 and 2 reticulocytes based on RNA content utilizing acridine orange supravital staining ; flow cytometric measurements were restricted to the youngest fraction of reticulocytes based on transferrin receptor ( CD 71 ) staining . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The MLC modulating effect of Tf ( or Tf Gly ) was not dependent upon the Tf receptor CD 71 but appeared to be mediated by a Gly responsive receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Specifically , we demonstrate that murine dorsal keratinocytes characterized by their high levels of alpha ( 6 ) integrin and low to undetectable expression of the transferrin receptor ( CD 71 ) termed alpha ( 6 ) ( bri ) CD 71 ( dim ) cells , are enriched for epithelial stem cells because they represent a minor ( approximately 8 % ) and quiescent subpopulation of small blast like cells , with a high nuclear : cytoplasmic ratio , containing approximately 70 % of label retaining cells , the latter being a well documented characteristic of stem cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
RESULTS : BCEC displayed : ( 1 ) characteristic endothelial cell morphology ; ( 2 ) expression of endothelial cell markers ( i . e . , CD 51 , CD62P , CD 71 and cadherin 5 ) ; ( 3 ) marginal F actin localization ; ( 4 ) tight junction formation between the cells ; ( 5 ) expression of gamma glutamyl transpeptidase ( gamma GTP ) ; ( 6 ) expression of P glycoprotein ( Pgp ) ; ( 7 ) functional transendothelial transferrin transport and uptake ; ( 8 ) restriction of paracellular transport ; and ( 9 ) high transendothelial electrical resistance ( TEER ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of CD 63 , a lysosomal marker , was variable , and there was no detectable expression of transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Prolongation of pancreatic islet graft survival by blocking transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Antibodies specific for the Tf receptor ( CD 71 ) did not block the effects of Tf or Tf Gly on apoptosis . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On the other hand , 25F9 antigen , the transferrin receptor ( CD 71 ) , KiM 8 ( CD 68 ) , RFD 1 ( marker of dendritic cells ) , RFD 7 ( marker of mature macrophages ) , RFD 9 ( marker of epithelioid cells and macrophages of germinal centers ) , and RM3 / 1 ( macrophages of late phase inflammation ) were restricted preferentially to mature AM . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
FACS analysis showed that the mean fluorescence intensity ( MFI ) corresponding to monocyte specific LPS receptor CD 14 was significantly decreased while MFI corresponding to macrophage specific transferrin receptor CD 71 was significantly increased in cells maintained in vitro on three dimensional COL gel compared to two dimensional COL substrata . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Both the A 24 antibody and IgA 1 myelomas bind a cell surface protein that is identified as the transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of transferrin receptors ( CD 71 ) correlated with the extent of globin chain stimulation . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An arthritogenic subpopulation of CD 4 ( + ) T cells , enriched by either negative or positive selection , expressed the activation markers CD 25 ( IL 2 receptor alpha ) , CD 71 ( transferrin receptor ) , CD 134 ( OX 40 antigen ) and MHC class 2 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
FACS analysis indicated that most Vbeta 13 ( + ) cells were `` large ' ' cells ( IL 2R ( + ) ) and expressed the activation marker , transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
K 562 erythroleukemia cells and IEC 6 rat cells were examined using confocal microscopy and antibodies raised against DMT 1 ( Nramp 2 , DCT 1 ) , transferrin receptor ( CD 71 ) , beta ( 3 ) integrin ( CD 61 ) , mobilferrin ( calreticulin ) , and Hephaestin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The procedure is based on an immunochemical reagent that differentially labels the most immature fraction of RETs from mature erythrocytes based on the expression level of the transferrin receptor ( also known as CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In this manuscript we describe the induction of the CD 71 transferrin receptor in human promyelocytic leukemia HL 60 cells following treatment with benzamide riboside . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Serum citrate levels , haptoglobin haplotypes and transferrin receptor ( CD 71 ) in patients with HIV 1 infection . ^^^ We determined serum citrate levels , haptoglobin ( Hp ) haplotypes , expression of transferrin receptor ( CD 71 ) on cell lines infected with HIV 1 as well as iron markers including blood iron , transferrin and ferritin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN , with FcalphaRI ( CD 89 ) being initially involved in the formation of circulating IgA containing complexes and , subsequently , transferrin receptor ( CD 71 ) in mediating mesangial deposition of IgA 1 complexes . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The rise in CD 117 expression to high levels mirrored that of the transferrin receptor ( CD 71 ) , and the subsequent reduction in CD 117 was inversely related to increases in expression of glycophorin A . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Our data indicate that the Arg200Trp substitution impairs the interaction of VHL with HIF1alpha , reducing the rate of degradation of HIF1alpha and resulting in increased expression of downstream target genes including EPO ( encoding erythropoietin ) , SLC2A1 ( also known as GLUT 1 , encoding solute carrier family 2 ( facilitated glucose transporter ) , member 1 ) , TF ( encoding transferrin ) , TFRC ( encoding transferrin receptor ( p 90 , CD 71 ) ) and VEGF ( encoding vascular endothelial growth factor ) . . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Flow cytometric , confocal microscopic , and biochemical analyses show that CD94 / NKG2A continuously recycles in an active process that requires the cytoskeleton between the cell surface and intracellular compartments that are distinguishable from recycling compartments used by well characterized receptors , such as transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Marrow was isolated from the tibia , stained with R phycoerythrin conjugated mouse anti rat CD 71 ( transferrin receptor on proliferating cells ) monoclonal antibody , and then analyzed by FC for myeloid : erythroid ( M : E ) ratios . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Recently , this group has characterized a new receptor for IgA , the transferrin receptor ( CD 71 ) , expressed on mesangial cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We therefore analyzed the role of complement receptors 1 ( CD 35 ) and 3 ( CD11b / 18 ) , the lipopolysaccharide ( LPS ) receptor ( CD 14 ) , the beta ( 1 ) integrin chain of the fibronectin receptor ( CD 29 ) , the intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) and the transferrin receptor ( CD 71 ) in the complement independent uptake of L . pneumophila . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Cross linking with a stimulatory anti CD 28 antibody resulted in an increased expression of CD 71 ( transferrin receptor ) or CD 25 ( interleukin 2 alpha receptor subunit ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
EXPLY 37 had no effect on T lymphocyte activation , measured as proliferation as well as expression of early and late cell surface antigens CD 69 , CD 25 ( IL 2R alpha ) and CD 71 ( transferrin receptor ) at the cell membrane . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Expression of alpha4beta1 integrin ( CD49d / CD29 ) , alpha5beta1 integrin ( CD49e / CD29 ) and transferrin receptor ( CD 71 ) on peripheral blood and bone marrow erythroblasts and on erythroid precursors grown in vitro was studied by flow cytometry and immunocytochemistry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Values from flow cytometric quantitation of glycophorin A , transferrin receptor ( CD 71 ) , and hemoglobin A proteins correlated with gene expression results . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Antibodies against the following cell surface markers were used : CD 45 ( leukocytes ) , CD 3 ( T lymphocytes ) , CD 19 ( B lymphocytes ) , CD 16 ( Fc receptor ) , glycophorin A ( erythroid lineage cells ) , and CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
After cell count and differentiation of second morning urine samples with New Sternheimer and Papanicolaou stains , immunocytochemistry was performed using antibodies against the following antigens : CD 2 , CD 4 , CD 8 , CD 25 , CD 71 ( transferrin receptor ) , HLA DR and cytokeratin ( Lu 5 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Despite intense proliferation , these cells lost the expression of CD 25 , the alpha chain of the IL 2 receptor and CD 71 , the transferrin receptor . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the present study , we have examined parameters of oxidative stress and intracellular iron in activated T cells and correlated these data with the expression of ferritin , heme oxygenase 1 ( HO 1 ) , and the transferrin receptor CD 71 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Quantitative and structural changes of IgA 1 play a key role in the development of the disease due to functional abnormalities of two IgA receptors : The FcalphaR ( CD 89 ) expressed by blood myeloid cells and the transferrin receptor ( CD 71 ) on mesangial cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Besides the components of the CD 4 receptor complex , CD 4 and lck , we have identified by tandem mass spectrometry 17 tryptic peptides from transferrin receptor CD 71 , three peptides from protein phosphatase CD 45 , and one peptide from 4F2 lymphocyte activation antigen CD 98 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The impaired maturation of erythroblasts during infection was associated with a shift in the transferrin receptor ( CD 71 ) expression from the TER 119 ( + ) population to B 220 ( + ) population . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Proliferation capacity was assessed by flow cytometry analyzing DNA content and expression of transferrin receptor ( CD 71 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The expression of CD 71 ( transferrin receptor ) on CD4+ T cells and of the costimulatory molecule CD 86 on B lymphocytes was significantly increased in SLE patients . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
However , unlike the fiber biotinylated vector , Ad 9 BAP failed to retarget to cells with biotinylated antibodies including anti CD 71 against the transferrin receptor . ^^^ In contrast , Ad 9 BAP was retargeted if transferrin , the cognate ligand for CD 71 , was used as a ligand rather than the anti CD 71 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Furthermore , there is a shift in transferrin receptor ( CD 71 ) expression from TER119+ cells to a non erythroid population . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Based on our previous work in both adult murine and neonatal human foreskin , we demonstrate that cell surface levels of the alpha 6 integrin and the transferrin receptor ( CD 71 ) are valid markers for resolving a putative stem cell , transit amplifying and differentiating compartment in adult human skin by flow cytometry . ^^^ Specifically , epidermal cells expressing high levels of alpha 6 integrin and low levels of the transferrin receptor CD 71 ( phenotype alpha 6 ( bri ) CD 71 ( dim ) ) exhibit several stem cell characteristics , comprising a minor population ( 2 % 5 % ) of the K 14 ( bri ) fraction , enriched for quiescent and small blast like cells with high clonogenic capacity , lacking the differentiation marker K 10 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Mice bearing i . p . ascites tumor had elevated serum TGF beta 1 , hemoglobulinemia , splenic lymphopenia , impaired response of the T cells to mitogen and reduced expression of transferrin receptor ( CD 71 ) on the bone marrow cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We also investigated the expression of the transferrin receptor CD 71 on cockade+ alveolar macrophages . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
An early marker for reticulocytes is CD 71 ( transferrin receptor ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The MicroFlow PLUS method ( Litron Laboratories , Rochester , NY ) for MN analysis by flow cytometry is based on the binding of FITC labeled antibodies to the CD 71 transferrin receptor of immature RETs , on parallel RNA degradation , and on propidium iodide staining of DNA present as micronuclei . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
METHODS : Venous blood obtained seven times during post injury days 1 through 13 from 61 patients with an injury severity score > 20 was assessed by flow cytometry for monocytes ( CD14+ ) expressing HLA DR or CD 71 ( transferrin receptor ) and for circulating levels of interleukin ( IL ) 1alpha , IL 1beta , IL 6 , soluble CD 14 ( sCD 14 ) , tumor necrosis factor alpha ( TNF alpha ) , prostaglandin E ( 2 ) ( PGE ( 2 ) ) , thromboxane B ( 2 ) ( TXB ( 2 ) ) , and endotoxin . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In summary , our data reveal that quantitative and structural changes of IgA 1 play a key role on the onset of the disease due to functional abnormalities of two IgA receptors : the Fc alphaRI ( CD 89 ) expressed by blood myeloid cells and the transferrin receptor ( CD 71 ) on mesangial cells . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Moreover , in Ramos cells , where c Myc is expressed at a high level , H ferritin expression is down regulated , transferrin receptor ( CD 71 ) expression is increased , and ferritin translation is inhibited . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Flow cytometric analysis indicated that parasite DNA is primarily found in mature erythrocytes that expressed Babesia antigens but not the transferrin receptor CD 71 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Hb , hematocrit , erythrocyte indices ( mean erythrocyte volume , mean erythrocyte Hb and mean erythrocyte Hb concentration ) , serum iron ( SI ) levels , iron binding capacity , transferrin receptor ( CD 71 ) and serum ferritin levels were measured . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Parallel hybridization with the cDNA encoding transferrin receptor ( TFRC ) refined its localization to 3q29 , in agreement with previously published results and in a distal position to CHEL 2 , whereas haptoglobin cDNA ( HPcDNA ) was correctly mapped at 16q24 , distal to CHEL 3 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The recent genetic linkage assignment of the CHE 1 locus of the CHE gene to chromosome 3q was confirmed and further refined to 3q21 q 26 , close to the genes coding for transferrin ( TF ) and transferrin receptor ( TFRC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
A NotI linking clone NL 2 252 ( D3S1678 ) containing transferrin receptor ( TFRC ) gene was used as an initial point for chromosomal jumping . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
The genes which were selected for their known function and their potential involvement in tumour development included the genes for ribosomal protein L 22 ( RPL 22 ) , butyrylcholinesterase ( BCHE ) , glucose transporter 2 ( SLC2A2 ) , transferrin receptor ( TFRC ) , thrombopoietin ( THPO ) and the phosphatidylinositol 3 kinase catalytic alpha polypeptide ( PIK3CA ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Two distinct but highly homologous proteins , IRP 1 and IRP 2 , bind IREs with high affinity when cells are depleted of iron , inhibiting translation of some transcripts , such as ferritin , or turnover of others , such as the transferrin receptor ( TFRC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
ACPP , ADCY 5 , APOD , BCHE , CD 86 , DRD 3 , GAP 43 , PCCB , RAF 1 , RHO , SI , TF , TFRC , TOP2B and ZNF 148 . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Transferrin receptor ( TFRC ) is a membrane bound protein expressed in larger amounts in proliferating , e . g . , malignant , cells than in quiescent cells . ^^^ The aim of this study was the investigation of the expression of TFRC and transferrin in human pancreatic cancer and in neuroendocrine tumours of the pancreas . ^^^ The expression of TFRC , transferrin and cytokeratin was studied by standard immunohistochemistry . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
In the Prostate , Lung , Colorectal and Ovarian Cancer Screening Trial , 679 persons with advanced distal adenoma and 697 control persons were genotyped for the two major HFE mutations ( C282Y and H63D ) , one HFE polymorphism ( IVS2+4 ) , and one polymorphism ( G142S ) in the transferrin receptor gene ( TFRC ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Case control studies have reported associations between HFE mutations C282Y / H63D and several cancers , some of which in interaction with the transferrin receptor gene TFRC or dietary iron intake . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
We examined four genes as candidates for the F4acR locus : the transferrin receptor gene ( TFRC ) and three genes members of the glucosyl / galactosyltransferase family ( B3GnT5 , B3GALT3 and B4GALT4 ) . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
Quantitative real time RT PCR was used to investigate the effects of prototypical drug metabolizing enzyme inducers rifampicin ( Rif ) , dexamethasone ( Dex ) , and omeprazole ( Ome ) on mRNA expression levels of the housekeeping genes beta actin ( ACTB ) , glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , beta glucuronidase ( GUSB ) , hypoxanthine phosphoribosyltransferase 1 ( HPRT 1 ) , peptidylprolylisomerase A ( PPIA ) , TATA box binding protein ( TBP ) , and transferrin receptor ( TFRC ) in primary cultures of cryopreserved human and rat hepatocytes . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
This study analyzed the clinical effect of messenger RNA ( mRNA ) expression for PIK3CA ( the gene that encodes phosphatidylinositol 3 kinase catalytic alpha polypeptide ) and TFRC ( the gene that encodes the transferrin receptor ) , which map within chromosome 3q in ESCC . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
On the other hand , transferrin receptor ( TFRC ) , phosphoglycerate kinase 1 ( PGK 1 ) , hypoxanthine ribosyltransferase ( HPRT 1 ) and beta 2 microglobin ( B2M ) show variable expression among the studied samples and appear as less suitable reference genes for data normalization . ^^^
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02786 and P02787	Pubmed	SVM Score :0.0
NA