| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| Both the A 24 antibody and IgA 1 myelomas bind a cell surface protein that is identified as the transferrin receptor ( CD 71 ) . ^^^ The transferrin receptor selectively binds IgA 1 antibodies , monomeric better than polymeric forms , and the IgA 1 binding is inhibitable by transferrin . ^^^ The characterization of transferrin receptor as a novel IgA 1 receptor on renal mesangial cells suggests its potential involvement in the pathogenesis of IgA nephropathy . . ^^^ |
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| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| We propose a model wherein two types of IgA receptors participate in sequential steps to promote the development of IgAN , with FcalphaRI ( CD 89 ) being initially involved in the formation of circulating IgA containing complexes and , subsequently , transferrin receptor ( CD 71 ) in mediating mesangial deposition of IgA 1 complexes . . ^^^ |
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| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| Quantitative and structural changes of IgA 1 play a key role in the development of the disease due to functional abnormalities of two IgA receptors : The FcalphaR ( CD 89 ) expressed by blood myeloid cells and the transferrin receptor ( CD 71 ) on mesangial cells . ^^^ |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| Glycosylation and size of IgA 1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy . ^^^ Transferrin receptor ( TfR ) has been identified as a candidate IgA 1 receptor expressed on human mesangial cells ( HMC ) . ^^^ |
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| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| Transferrin receptor and Fc alpha / mu receptor may not be the major IgA 1 receptor on human mesangial cells . ^^^ |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| Engagement of transferrin receptor by polymeric IgA 1 : evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy . ^^^ The transferrin receptor ( TfR ) was identified previously as an IgA 1 receptor , and it was found that , in biopsies of patients with IgAN , TfR is overexpressed and co localizes with IgA 1 mesangial deposits . ^^^ |
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| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| In summary , our data reveal that quantitative and structural changes of IgA 1 play a key role on the onset of the disease due to functional abnormalities of two IgA receptors : the Fc alphaRI ( CD 89 ) expressed by blood myeloid cells and the transferrin receptor ( CD 71 ) on mesangial cells . ^^^ |
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| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : This result means there is a small amount of the unsubstituted and the sialylated N acetylgalactosamine residues ( Tn and sialyl Tn antigen , respectively ) , and abundant asialo Galbeta 1 , 3GalNAc ( TF antigen ) in the IgA 1 molecule . ^^^ |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02787 and P01876 |
Pubmed |
SVM Score :0.0 |
| NA |
|