| Interacting proteins: O60494 and P02787 |
Pubmed |
SVM Score :0.0 |
| In the present study , we report the identification of cubilin as a novel transferrin ( Tf ) receptor involved in catabolism of Tf . ^^^ Consistent with a cubilin mediated endocytosis of Tf in the kidney , lysosomes of human , dog , and mouse renal proximal tubules strongly accumulate Tf , whereas no Tf is detectable in the endocytic apparatus of the renal tubule epithelium of dogs with deficient surface expression of cubilin . ^^^ Mice with deficient synthesis of megalin , the putative coreceptor colocalizing with cubilin , also excrete high amounts of Tf and fail to internalize Tf in their proximal tubules . ^^^ However , in contrast to the dogs with the defective cubilin expression , the megalin deficient mice accumulate Tf on the luminal cubilin expressing surface of the proximal tubule epithelium . ^^^ The megalin dependent , cubilin mediated endocytosis of Tf and the potential of the receptors thereby to facilitate iron uptake were further confirmed by analyzing the uptake of ( 125 ) 1 and ( 59 ) Fe labeled Tf in cultured yolk sac cells . . ^^^ |
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| Interacting proteins: O60494 and P02787 |
Pubmed |
SVM Score :0.0 |
| Impaired protein endocytosis in PTC of ClC 5 KO mice was demonstrated by ( 1 ) a major decreased uptake of injected 125I beta 2 microglobulin , but not of the fluid phase tracer , FITC dextran , ( 2 ) reduced labeling of endosomes by injected peroxidase and for the endogenous megalin / cubilin ligands , vitamin D and retinol binding proteins , and ( 3 ) urinary appearance of low molecular weight proteins and the selective cubilin ligand , transferrin . ^^^ |
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| Interacting proteins: O60494 and P02787 |
Pubmed |
SVM Score :0.0 |
| Here , we show that ARH is absent from the VE , and Dab 2 is required for uptake of megalin , its co receptor cubilin , and a cubilin ligand , transferrin , from the brush border of the VE into intracellular vesicles . ^^^ |
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| Interacting proteins: O60494 and P02787 |
Pubmed |
SVM Score :0.0 |
| NA |
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