| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| The antibodies used were Ki 67 , cytokeratin 8 . 12 , and antibodies against the receptors for epidermal growth factor ( EGFr ) and transferrin ( TFr ) . ^^^ EGFr and TFr were seen in the basal layer in SE 21 . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor receptors ( EGFR ) and transferrin receptors ( TFR ) are known to be involved in cell proliferation and to be expressed in normal human epidermis . ^^^ Monoclonal antibodies to EGFR and TFR were applied on frozen skin sections using an amplification biotin streptavidin fluorescein technique . ^^^ These results suggest that in embryonic and fetal epidermis , TFR expression is not correlated with cellular proliferation , whereas EGFR appear to be associated with proliferating and undifferentiated cells . . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemical and flow cytometric techniques , we have studied the significance of cellular expression of the Ki 67 antigen , epidermal growth factor receptor ( EGFR ) , the transferrin receptor ( TFR ) and DNA ploidy status in a prospective analysis of patients with SCCs of the head and neck region . ^^^ All 42 fresh tumour samples ( five well differentiated ; 28 moderately differentiated ; nine poorly differentiated ) expressed both EGFR and TFR to varying degrees . ^^^ Our results suggest that EGFR and TFR are widely distributed on SCCs , especially on proliferating cells at the invading tumour margin . ^^^ In addition , there is a close spatial correlation between cells expressing EGFR , TFR and those expressing the Ki 67 antigen . ^^^ Tumours in which the staining intensity for both EGFR and TFR was intense invariably expressed the Ki 67 antigen in a high proportion of cells . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Growth factor receptor expression , including PDGF R , NGF R , EGF R , IR , IGF 1 R , TFR and c kit , was studied by immunohistochemistry and FACSscan analysis . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry showed transferrin receptor ( TfR ) , Ki 67 , and epidermal growth factor receptor ( EGFR ) in OKK TKm , but less or none in OKK TKp . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| AIMS To investigate the proliferative activity ( given by the Ki 67 index ) of the normal , atypical , and neoplastic urothelium and its relation to the cellular reactivity for the epidermal growth factor ( EGFr ) and transferrin ( Tfr ) receptors . ^^^ METHODS The Ki 67 index and the level of EGFr and Tfr reactivity were determined on frozen sections from 82 patients with urothelial cancer . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| We have followed the transfer of EGF EGF receptor ( EGFR ) complexes from endosomal vacuoles that contain transferrin receptors ( TfR ) to lysosome vacuoles identified by their content of HRP loaded as a 15 min pulse 4 h previously . ^^^ With time these accumulating MVB undergo a series of maturation changes that include the loss of TfR , the continued recruitment of EGFR , and the accumulation of internal vesicles , but they remain LAMP 1 and M6PR negative . ^^^ Together our observations suggest that the transfer of EGF EGFR complexes from the TfR containing endosome compartment to the lysosomes that degrade them employs a single vacuolar intermediate , the maturing MVB , and can be achieved by a single heterotypic fusion step . . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| The internalization rate for the epidermal growth factor receptor was also measured , with or without induction of TfR expression . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| By measuring the rates of endocytosis for either the overexpressed receptor , or that of other endogenous receptors , we were able to show that the endocytosis of identical receptors could be saturated , but a complete lack of competition exists between the transferrin receptor ( TfR ) , the low density lipoprotein receptor , and the epidermal growth factor receptor . ^^^ During high levels of TfR expression , however , a significant increase in the amount of surface Lamp 1 , but not low density lipoprotein receptor , epidermal growth factor receptor , or Lamp 2 , is detected . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that an unidentified kinase substrate is required for endocytosis of the epidermal growth factor receptor ( EGFR ) , the prototypical ligand inducible receptor , but not of the transferrin receptor ( TfR ) , the prototypical constitutively internalized receptor . ^^^ Here , we show that tyrosine phosphorylation of Eps 15 is necessary for internalization of the EGFR , but not of the TfR . ^^^ A phosphorylation negative mutant of Eps 15 acted as a dominant negative on the internalization of the EGFR , but not of the TfR . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the efficacy of two biomarkers , transferrin receptor ( TfR ) and epidermal growth factor receptor ( EGFR ) , for the early detection of cervical dysplasia and to explore the relationship of E 5 , one of three viral oncogenes expressed by the human papillomavirus ( HPV ) , to TfR and EGFR . ^^^ STUDY DESIGN : Two hundred seventy four patients were evaluated in two separate preclinical studies using EGFR and TfR in fluorescent antibody based assays . ^^^ CONCLUSION : Both EGFR and TfR assays detected HSIL with very high accuracy ( 100 % and 96 . 3 % , respectively ) . ^^^ Specificity of the TfR assay was slightly higher ( 81 . 3 % ) than that of the EGFR assay ( 73 . 3 % ) . ^^^ HPV E 5 induced disruption of intracellular endosomal acidification and its effects upon both EGFR and TfR may provide the specific mechanistic connection between overexpression of these receptor proteins , and HPV in fection and integration . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| We undertook a comparative study of the presence of the epidermal growth factor receptor ( EGFR ) , interleukin 13 receptor ( IL13R ) , interleukin 4 receptor ( IL4R ) , and transferrin receptor ( TfR ) determined by immunofluorescence microscopy among fresh frozen tumor samples from 38 patients with high grade gliomas ( glioblastoma multiforme or anaplastic astrocytoma ) . ^^^ The frequency of high receptor expression was 32 of 38 ( 84 % ) for EGFR , 30 of 38 ( 79 % ) for IL13R , 25 of 38 ( 66 % ) for TfR , and 17 of 38 ( 45 % ) for IL4R . ^^^ The safety profile may be improved with an agent directed to EGFR versus agents directed to TfR , IL4R , or IL13R . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the endosome associated protein hrs is a subunit of a protein complex containing actinin 4 , BERP , and myosin 5 that is necessary for efficient TfR recycling but not for EGFR degradation . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Conversely , Abi 1 and N WASP , but not WAVE , regulate actin based vesicular transport , epidermal growth factor receptor ( EGFR ) endocytosis , and EGFR and transferrin receptor ( TfR ) cell surface distribution . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| These contained EGF , EGFR , clathrin , and Grb 2 but not the TfR . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Receptors for epidermal growth factor ( EGFr ) and nerve growth factor ( NGFr ) were found in many cells in short term cultures , but the transferrin receptor ( Tr ) was found in only a few cells of 87HG 28 . ^^^ In permanent cell lines , differentiation antigens and EGFr decreased and Tr increased markedly . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| The markers studied were transferrin receptor ( TR ) , Ki 67 antigen , and epidermal growth factor receptor ( EGFR ) . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| The identification of EGFR ' s on ependymomas and TR ' s on medulloblastomas suggests that malignant central nervous system tumors that spread by cerebrospinal fluid pathways may be treatable by intrathecal antibody toxin conjugates . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| The present investigation examined the differential expression of the full length ( fl ) and the truncated ( tr ) forms of the epidermal growth factor receptor ( EGFr ) in the preimplantation mouse uterus and blastocyst . ^^^ Northern blot hybridization using a complementary RNA probe specific to the full length form ( EGFr fl ) detected a 6 . 5 kb transcript , whereas that of the truncated form ( EGFr tr ) detected a 2 . 7 kb transcript in the preimplantation mouse uterus on days 1 and 4 of pregnancy ( day 1 = vaginal plug ) . ^^^ In situ hybridization using these probes detected the EGFr fl transcripts only in the stroma and myometrium , but not in the epithelium , whereas EGFr tr transcripts were detected in all major uterine cell types . ^^^ The results concur that the EGFr tr transcript is expressed in the epithelium , stroma and myometrium , whereas that of the EGFr fl transcript is not expressed in the epithelium . ^^^ In the preimplantation blastocyst , RT PCR detected the EGFr fl messenger RNA , but not the EGFr tr messenger RNA . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| At 20 degreesC dIgA pIgR internalize to interconnected groups of vacuoles and tubules that comprise the endosomal compartment and in which they codistribute with internalized transferrin receptors ( TR ) and epidermal growth factor receptors ( EGFR ) . ^^^ We propose that the differential sorting of occupied receptors within the MDCK endosome is achieved by this clathrin based mechanism continuously retrieving receptors like TR from the pathways that deliver pIgR to the apical surface and EGFR to the lysosome . . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Soluble TR stimulated erbB 4 tyrosine phosphorylation in MKN 28 gastric cancer cells , although it was weak compared to neuregulin induced erbB 4 tyrosine phosphorylation ; this suggests that TR might be a ligand for erbB 4 or erbB 4 related receptor tyrosine kinase . ^^^ The modular features suggest multiple roles for TR ; these include functioning as a ligand for erbB receptor , a regulator of TGF beta related growth factor signaling by direct interaction through the follistatin modules , and a G protein coupled receptor . . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| These results correlated with low levels of surfactant proteins in these lungs ; ( 3 ) TR and RAR inhibition indicate their roles through reduced or retarded proliferation and differentiation processes in the severely hypoplastic lungs ; ( 4 ) GR down regulation in developing fetal murine hypoplastic lungs indicate delayed development , and GR up regulation in affected neonates may be induced by stress / stretch caused at birth due to air breathing ; ( 5 ) Down regulation of EGFR indicate altered mesenchymal epithelial interactions and possible influence on lung proliferation and differentiation . . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Elegant studies have demonstrated that a single strand D sequence binding protein ( ssDBP ) is phosphorylated by EGFR and binds to the D sequence element in the AAV terminal repeat ( TR ) . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Prognostic significance of immunohistochemical parameters in breast carcinomas . 136 breast carcinomas were investigated immunohistochemically for alpha lactalbumin ( ALA ) , lactoferrin ( Lfr ) , human milk fat globule membrane antigen ( HMFG 2 ) , transferrin receptor ( TrfR ) , Ki 67 and epidermal growth factor receptor ( EGFR ) . ^^^ It was found that estrogen receptor ( ER ) was inverse related to TrfR , Ki 67 and EGFR whereas progesterone receptor ( PgR ) was inverse correlated to Ki 67 solely . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| These results were compared with growth fractions ( Ki 67 immunoreactivity and Transferrin receptor ( TrfR ) expression ) , histologic tumor type , tumor grading , axillary lymph node status and estrogen receptor ( ER ) status . 60 . 2 % were EGFR positive . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| An increase in the number of epidermal growth factor and transferrin receptors ( EGFR , TrfR ) is induced by Ara C on these cells . ^^^ Maximal EGFR up regulation occurs 96 h after the beginning of Ara C exposure while maximal TrfR up regulation is detected 24 h later . ^^^ These effects occur without changes in the affinity of EGFR and TrfR for their ligands . ^^^ Two classes of EGF binding sites with a Kd of 0 . 055 nM and 2 . 3 nM respectively , and one class of transferrin binding sites with a Kd of about 4 nM are detected on both untreated and Ara C treated KB cells . [ 3H ] Thymidine uptake is clearly stimulated on KB cells by nanomolar concentrations of EGF and transferrin , whereas in Ara C treated cells [ 3H ] thymidine uptake is not increased by EGF and transferrin under conditions where maximal EGFR and TrfR up regulation occurs . ^^^ The enhanced EGF and transferrin binding is paralleled by a twofold increase of in vitro targeting of Ara C treated KB and A 549 cells with anti EGFR 108 . 1 mAb and anti TrfR OKT 9 mAb . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Using serial frozen sections , monoclonal antibodies and an indirect immunoperoxidase method , 13 fibroadenomas ( FA ) and 3 cystosarcomas phyllodes ( CSP ) were analyzed for the expression of Egp 34 , HEA 319 antigen , leucocyte differentiation antigens CD 10 , CD 30 , CD 57 , CD 72 , CDw 75 , and CD 77 , epidermal growth factor receptor ( EGFR ) , estrogen ( ER ) and progesterone receptor ( PR ) , and transferrin receptor ( CD 71 ) . ^^^ This was also true for EGFR and CD 71 in both duct cells and myoepithelial cells of FA . ^^^ In contrast , stromal cells of FA were able to co express EGFR and CD 71 in the absence of PR and ER . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| CD45+ cells as well as activated lymphocytic cells , expressed by the activation immunophenotype ( CD 1 , HLA DR , CD 25 , CD 71 , EGF R ) were found frequently in all groups . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , ITF and ITF thioredoxin cell surface binding at 4 degrees C colocalized not with EGF R , but with CD 71 , which is found in clathrin coated pits , suggesting that integration of trefoil peptide responses may occur after internalization . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| Antibodies against integrin beta 1 , epidermal growth factor receptor ( EGFR ) , K 19 , enolase alpha , and CD 71 stained the basal cells of the limbus more brightly than the suprabasal epithelia . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| A relatively higher expression level in basal limbal cells was observed for p 63 , alpha enolase , K5 / 14 , and HGF R , whereas there were no significant differences in staining intensity for beta catenin , integrins alphav , beta 1 , beta 2 , and beta 5 , CD 71 , EGF R , TGF beta RI , TGF beta RII , and TrkA between limbal and corneal basal epithelial cells . ^^^ |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02786 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
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