| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| Here , we describe a distinct , previously unrecognized receptor named CXCR 3 B , derived from an alternative splicing of the CXCR 3 gene that mediates the angiostatic activity of CXCR 3 ligands and also acts as functional receptor for CXCL 4 . ^^^ Human microvascular endothelial cell line 1 ( HMEC 1 ) , transfected with either the known CXCR 3 ( renamed CXCR 3 A ) or CXCR 3 B , bound CXCL 9 , CXCL 10 , and CXCL 11 , whereas CXCL 4 showed high affinity only for CXCR 3 B . ^^^ Remarkably , primary cultures of human microvascular endothelial cells , whose growth is inhibited by CXCL 9 , CXCL 10 , CXCL 11 , and CXCL 4 , expressed CXCR 3 B , but not CXCR 3 A . ^^^ |
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| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| Indeed , in addition to the classic form of CXCR 3 receptor , which we have renamed as CXCR 3 A , a novel CXCR 3 receptor variant ( CXCR 3 B ) was identified , that not only mediates the angiostatic activity of CXCR 3 ligands , but also acts as functional receptor for CXCL 4 . ^^^ |
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| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| CXCR 3 mediated opposite effects of CXCL 10 and CXCL 4 on TH 1 or TH 2 cytokine production . ^^^ BACKGROUND : Two variants of the CXCR 3 receptor exist , one ( CXCR 3 A ) reactive with CXCL 9 , CXCL 10 , and CXCL 11 and the other ( CXCR 3 B ) also reactive with CXCL 4 . ^^^ The opposite effects of CXCL 10 and CXCL 4 on TH 1 and TH 2 cytokine production were inhibited by an anti CXCR 3 antibody able to neutralize both CXCR 3 A and CXCR 3 B and were apparently related to the activation of distinct signal transduction pathways . ^^^ CONCLUSION : CXCL 10 and CXCL 4 exert opposite effects on the production of human TH 1 and TH 2 cytokines , likely through their respective interaction with CXCR 3 A or CXCR 3 B and the consequent activation of different signal transduction pathways . ^^^ |
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| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| By contrast , members of the CXC chemokine family , such as platelet factor 4 ( PF 4 ; CXCL 4 ) and interferon inducible CXC chemokines are potent inhibitors of angiogenesis , and use CXCR 3 on endothelium to mediate their angiostatic activity . ^^^ |
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| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P49682 |
Pubmed |
SVM Score :0.0 |
| NA |
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