| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The interactions of activated platelets with monocytes and atherosclerotic arteries led to delivery of the platelet derived chemokines CCL 5 ( regulated on activation , normal T cell expressed and secreted , RANTES ) and CXCL 4 ( platelet factor 4 ) to the monocyte surface and endothelium of atherosclerotic arteries . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Platelets also increase monocyte recruitment in atherosclerosis by secreting chemokines such as platelet factor 4 ( CXCL 4 ) or RANTES ( CCL 5 ) , which trigger monocyte arrest in atherosclerotic arteries . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Platelet derived chemokines , such as regulated on activation , normal T expressed and secreted ( RANTES ; CC chemokine ligand 5 ) , platelet factor 4 [ PF 4 ; CXC chemokine ligand 4 ( CXCL 4 ) ] , and epithelial neutrophil activating protein 78 ( ENA 78 ; CXCL 5 ) , or precursors , such as beta thromboglobulin , which can be processed to neutrophil activating protein 2 ( NAP 2 ; CXCL 7 ) , may play an important role in monocyte recruitment during atherogenesis . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| For example , microparticles in these experiments were found to contain membrane surface proteins including GPIIIa , GPIIb , and P selectin , as well other platelet proteins such as the chemokines CXCL 4 , CXCL 7 , and CCL 5 . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Statistical analysis showed lower PLT content per unit in PCT PCs , higher levels of activation variables in PCT PCs , and higher levels and accumulation rate of CCL 5 , CXCL 4 , TGF beta , and CXCL 8 in PCT PCs . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| In a modified Boyden chamber assay , we studied migratory responses toward the members of the chemokine family RANTES , monocyte chemotactic protein 1 ( MCP 1 ) , and macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) ( C C subfamily ) , and IL 8 , platelet factor 4 ( PF 4 ) , and neutrophil activating peptide 2 ( NAP 2 ) ( C 10 C subfamily ) . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| When tested at 5 10 10 ( 9 ) mol / L , the decrease in histamine release by RANTES was 69 . 2 % + / 3 . 5 % , by MIP 1 alpha 48 . 8 % + / 3 . 1 % , by MIP 1 beta 42 . 9 % + / 3 . 1 % , by PF 4 56 . 5 % + / 2 . 9 % , by IL 8 41 . 2 % + / 2 . 2 , by CTAP 3 27 % + / 4 . 4 % , and by IP 10 15 . 3 % + / 2 . 6 % . ^^^ We have therefore characterized RANTES , MIP 1 alpha , MIP 1 beta , CTAP 3 , PF 4 , IL 8 , and IP 10 as inhibitors of MCAF induced histamine release . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| RANTES ( Regulated on activation normal T expressed and secreted ) seems to be the most important chemokine which belongs to Platelet factor 4 ( PF 4 ) superfamily , since RANTES is revealed as a chemotactic factor for eosinophils as well as memory T cells or monocytes . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The chemokine superfamily comprise two families of small secreted proteins that , with the exception of RANTES , beta TG , and PF 4 , are not expressed in resting cells but are rapidly induced in response to various inflammatory and mitogenic stimuli . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| However , none of a series of radiolabelled chemokines ( IL 8 , NAP 2 , GRO alpha , PF 4 , IP 10 , MCP 1 , MCP 2 , MCP 3 , 1 309 , RANTES and MIP 1 alpha ) and other ligands ( C3a and leukotriene B 4 ) bound to Jurkat transfectants that stably expressed either MDR 15 or BLR 1 mRNA . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The chemokine family has been organized into two subgroups with MIP 1 alpha , MIP 1 beta , macrophage chemotactic and activating factor ( MCAF ) and RANTES belonging to one subgroup , and GRO alpha , MIP 2 alpha ( GRO beta ) , MIP 2 beta ( GRO gamma ) , platelet factor 4 ( PF 4 ) , IL 8 , and neutrophil activating peptide ( NAP ) 2 belonging to the other . ^^^ In contrast , MIP 1 beta , MIP 2 beta , GRO alpha , NAP 2 , and RANTES were not suppressive nor did they synergize with MIP 1 alpha , MIP 2 alpha , PF 4 , IL 8 , or MCAF to suppress . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| In the present study , the action of chemokines / intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine / intercrine alpha subfamily members [ interleukin 8 ( IL 8 ) ; growth related cytokine / melanoma growth stimulating activity ( GRO alpha / MGSA ) ; platelet factor 4 ( PF 4 ) ; beta thromboglobulin ( beta TG ) ; and interferon inducible protein 10 ( IP 10 ) ] and beta subfamily members [ monocyte chemotactic protein 1 / monocyte chemotactic and activating factor ( MCP 1 / MCAF ) ; regulated upon activation normal T cell expressed and presumably secreted ( RANTES ) ; macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) ; and macrophage inflammatory protein 1 beta ( MIP 1 beta ) ] . ^^^ The intracerebroventricular administration of three members of the alpha subfamily ( IL 8 , PF 4 , and IP 10 ) and two members of the beta subfamily ( MCP 1 / MCAF and RANTES ) decreased the short term ( 2 h ) food intake . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Platelet factor 4 ( PF 4 ) , but not IL 8 , monocyte chemoattractant protein 1 , RANTES , monocyte inflammatory protein ( MIP ) 1 alpha , or MIP 1 beta , can compete effectively with IP 10 for binding to the cell surface . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Transfected cells expressing high levels of LESTR mRNA did not bind radiolabeled NPY , IL 8 , NAP 2 , GRO alpha , PF 4 , IP 10 , MCP 1 , MCP 3 , MIP 1 alpha , HC 14 , I 309 , RANTES , C3a , or LTB 4 . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Many of the known agonists for leukocytes including 13 chemokines ( IL 8 , NAP 2 , GRO alpha , ENA 78 , IP 10 , PF 4 , MCP 1 , 2 and 3 , RANTES , MIP 1 alpha , MIP 1 beta and I 309 ) , three neuropeptides ( neuropeptide Y , somatostatin and calcitonin ) , as well as C5a , did not activate HMC 1 cells , indicating that C3a is one of a few protein ligands for which this cell line expresses specific receptors . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| We studied the effects of various chemokines including neutrophil activating peptide 2 ( NAP 2 ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , melanoma growth stimulating activity ( GRO ) , gamma interferon induced protein ( IP 10 ) , regulated on activation , normal T expressed and secreted ( RANTES ) , macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) , MIP 1 beta , and monocyte chemotactic protein 1 ( MCP 1 ) on Immunoglobulin ( IgE ) and IgG 4 production by human B cells . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| In addition , PF 4 , MCP 1 , RANTES and MIP 1 alpha were incapable of inducing direct histamine release from SMC . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| In contrast , the production of regulated on activation with normal T cell expressed and secreted ( RANTES ) , platelet factor 4 ( PF 4 ) and beta thromboglobulin ( beta TG ) were not potentiated . ^^^ These results suggest that the production of IL 8 and GRO alpha ( but not RANTES ) , PF 4 and beta TG , by megakaryocytes is potentiated by signalling through IL 1RI with the aid of TPO . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| None of the chemokines tested , such as platelet factor 4 ( PF 4 ) , eotaxin , stromal cell derived factor 1alpha ( SDF 1alpha ) and RANTES , had detectable activity against HHV 7 . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| RANTES , platelet factor 4 ( PF 4 ) , beta thromboglobulin ( beta TG ) , and transforming growth factor ( TGF ) beta 1 were also detected in these PCs , and their levels increased significantly on storage . ^^^ Substantial amounts of RANTES , PF 4 , beta TG , and TGF beta 1 occurred in Day 1 MCS+ LDP PCs , and , on storage , these levels rose significantly . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Neutrophil gelatinase B potentiates interleukin 8 tenfold by aminoterminal processing , whereas it degrades CTAP 3 , PF 4 , and GRO alpha and leaves RANTES and MCP 2 intact . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Although mRNAs for several chemokines were detectable by RT PCR in normal human megakaryoblasts , only RANTES , IL 8 , MCP 1 and PF 4 were found to be secreted by these cells . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Substantial amounts of PF 4 , beta TG and RANTES are released from platelets on activation , which may occur during storage . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| These analyses enabled the identification of seven thrombin releasable antimicrobial peptides from human platelets : platelet factor 4 ( PF 4 ) , RANTES , connective tissue activating peptide 3 ( CTAP 3 ) , platelet basic protein , thymosin beta 4 ( Tbeta 4 ) , fibrinopeptide B ( FP B ) , and fibrinopeptide A ( FP A ) . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The levels of certain cytokines regulated on activation , normal , T cell expressed , and secreted ( RANTES ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) and interleukin 7 ( IL 7 ) were measured by enzyme linked immunosorbent assay ( ELISA ) on days 1 , 5 and 7 . ^^^ RESULTS : The concentrations of RANTES , beta TG , PF 4 and IL 7 increased , during storage , in all units . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The chemokines platelet factor 4 ( PF 4 ) and RANTES ( regulated on activation normal T cell expressed and secreted ) are secreted by activated platelets and influence multiple cell types and biologic processes . ^^^ For instance , PF 4 inhibits progenitor cell proliferation and angiogenesis , while platelet derived RANTES is involved in vascular recruitment of monocytes . ^^^ However , little is known about functional interactions of PF 4 and RANTES . ^^^ Here we show that the presence of PF 4 enhanced the arrest of RANTES stimulated monocytes and monocytic cells on activated endothelial cells under flow conditions , while binding of PF 4 to the monocyte surface was increased by RANTES . ^^^ Both RANTES triggered arrest and PF 4 binding involved monocytic chondroitin sulfate . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| However three dimensional alignments of the human alpha granule chemokines Nap 2 ( neutrophil activating peptide ) and RANTES ( Regulated upon Activation Normal T Cell Expressed and Secreted ) with PF 4 revealed that LKNG , a surface exposed hydrophilic turn / loop , matched Nap 2 ( LKDG ) and RANTES ( TRKN ) peptides with similar features . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| This superfamily currently includes 14 distinct members : platelet factor 4 , beta thromboglobulin , neutrophil activating peptide 1 / interleukin 8 , gro , IP 10 , mig , ENA 78 , macrophage inflammatory proteins 1 alpha and 1 beta , monocyte chemoattractant protein 1 / JE , RANTES , HC 14 , C 10 , and 1 309 . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| IL 8 and related molecules , including platelet factor 4 , constitute the C 10 C class of the superfamily and a group of cytokines produced by haematopoietic cells constitute the RANTES / sis or C C class . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Those human cytokines known as interleukin 8 , platelet factor 4 , beta thromboglobulin , IP 10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features , whereas the second subset consisting of LD 78 , ACT 2 , 1 309 , RANTES , and macrophage chemotactic and activating factor ( MCAF ) are all closely linked on human chromosome 17 . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Unstimulated mast cells were chemoattracted only by monocyte chemotactic protein 1 and RANTES on vitronectin coated and , to a lesser extent , laminin coated filters , whereas IgE activated mast cells migrated in response to monocyte chemotactic protein 1 , regulated on activation normal T expressed and secreted , platelet factor 4 , and macrophage inflammatory protein 1 alpha on all three matrix proteins . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Comparison of 125I MGSA binding to the Duffy antigen and the human erythrocyte chemokine receptor showed that the specific 125I MGSA binding to both proteins was displaced by excess unlabeled MGSA , interleukin 8 , RANTES , monocyte chemotactic peptide 1 , and platelet factor 4 , but not by macrophage inflammatory protein 1 alpha or 1 beta . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The ability to inhibit collagen expression was also demonstrated by another member of the C 10 C branch of the platelet factor 4 superfamily , interleukin 8 ( IL 8 ) , but not by RANTES , MIP 1 alpha , or MIP 1 beta , which belong to the C C branch . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| The cytokine RANTES ( regulated on activation , normal T expressed and secreted ) is a member of the platelet factor 4 superfamily and is a chemoattractant for eosinophils . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| STUDY DESIGN AND METHODS : Analysis was done of pH and the levels of platelet factor 4 , beta thromboglobulin , interleukin 8 , RANTES , macrophage inflammatory protein 1 alpha , lactate dehydrogenase , and serotonin in the supernatant of stored PCs on Days 1 , 3 , 5 , and 8 . ^^^ CONCLUSION : Platelet factor 4 , beta thromboglobulin , and RANTES were released from platelets during storage and accumulated over time in the PCs . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Other chemokines , including neutrophil activating protein 2 , platelet factor 4 , RANTES , and macrophage chemotactic protein 1 , neither suppressed the proliferation of 32D cells nor induced a rise in intracellular calcium . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| One of the following test substances was also included in the culture : platelet factor 4 , beta thromboglobulin , platelet derived growth factor , serotonin , platelet activating factor , or RANTES . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Platelets are known to contain platelet factor 4 and beta thromboglobulin , alpha chemokines containing the CXC motif , but recent studies extended the range to the beta family characterized by the CC motif , including RANTES and Gro alpha . ^^^ |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| Stimulated platelets actively synthesize proinflammatory cytokines ( e . g . , CD40L , IL 1beta ) and are able to release chemokines ( i . e . , platelet factor 4 , RANTES ) which have been all involved in the inflammatory process associated with hypercholesterolemia . ^^^ |
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| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P13501 |
Pubmed |
SVM Score :0.0 |
| NA |
|