| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.50623483 |
| A chimeric mutant of PF 4 ( called PF 4 M2 ) which substitutes the first 11 N terminal residues for the first eight residues from homologous interleukin 8 forms symmetric homo tetramers with essentially the same heparin binding activity as native PF 4 . 0.50623483^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Transendothelial migration of neutrophils in response to CXCL 7 or IL 8 ( CXCL 8 ) was subject to modulation by CTAP 3 , but not CXCL 4 , as seen by drastic desensitization of the migratory response of neutrophils pre exposed to CTAP 3 , which was paralleled by selective down modulation of CXCR 2 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Although secreted CXCL 4 and CXCL4L1 differ in only three amino acids , CXCL4L1 was more potent in inhibiting chemotaxis of human microvascular endothelial cells toward interleukin 8 ( IL 8 ) / CXCL8 or basic fibroblast growth factor ( bFGF ) . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Statistical analysis showed lower PLT content per unit in PCT PCs , higher levels of activation variables in PCT PCs , and higher levels and accumulation rate of CCL 5 , CXCL 4 , TGF beta , and CXCL 8 in PCT PCs . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| RESULTS : When used alone , CCL 2 , CCL 3 , CCL 19 , CCL 20 , CXCL 4 , CXCL 5 , CXCL 8 , CXCL 9 , and XCL 1 caused dose dependent significant decreases in absolute numbers and cycling status of HPCs in vivo . ^^^ The following combinations of two chemokines resulted in in vivo myelosuppression at concentrations much lower than that induced by each chemokine alone : CCL 3 plus either CXCL 8 or CXCL 4 , CXCL 8 plus CXCL 4 , CCL 2 plus either CCL 20 or CXCL 9 , CCL 20 plus CXCL 9 , CXCL 5 plus either XCL 1 or CCL 19 , XCL 1 plus CCL 19 , and CCL 3 plus CCL 19 . ^^^ Also , mice injected with CXCL 8 , CXCL 4 , or the chimeric CXCL8 / CXCL4 protein CXCL8M1 manifested accelerated recovery of absolute numbers of HPCs in response to the toxic effects of Ara C administration . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| We now show by pulse field gel electrophoresis ( PFGE ) that the beta TG genes are closely linked to the PF 4 genes and to other previously mapped CXC SIGs , namely IL 8 ( encoding interleukin 8 ) , GRO 1 ( encoding a cytokine also called melanoma growth stimulatory activity ) , and two related genes GRO 2 and GRO 3 , on a single 700 kb Sfil fragment localized to chromosome bands 4q12 q 13 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Neutrophil attractant / activation protein 1 ( NAP 1 ) has sequence similarity to platelet factor 4 ( PF 4 ) and to NAP 2 ( a truncated from of connective tissue activating protein 3 [ CTAP 3 ( des 1 15 ) ] . ^^^ In contrast , PF 4 ( 59 70 ) regularly induced high chemotactic responses , although the EC 50 of 1 . 6 10 10 ( 5 ) M was 1 , 000 fold greater than that of NAP 1 . ^^^ The binding of fluoresceinated NAP 1 to neutrophils was inhibited by unlabeled NAP 1 or NAP 2 but not by PF 4 or PF 4 ( 59 70 ) . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| In the present study , the action of chemokines / intercrines on the regulation of feeding was investigated using the intracerebroventricular microinfusion of chemokine / intercrine alpha subfamily members [ interleukin 8 ( IL 8 ) ; growth related cytokine / melanoma growth stimulating activity ( GRO alpha / MGSA ) ; platelet factor 4 ( PF 4 ) ; beta thromboglobulin ( beta TG ) ; and interferon inducible protein 10 ( IP 10 ) ] and beta subfamily members [ monocyte chemotactic protein 1 / monocyte chemotactic and activating factor ( MCP 1 / MCAF ) ; regulated upon activation normal T cell expressed and presumably secreted ( RANTES ) ; macrophage inflammatory protein 1 alpha ( MIP 1 alpha ) ; and macrophage inflammatory protein 1 beta ( MIP 1 beta ) ] . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| This includes interleukin 8 ( IL 8 ) and platelet factor 4 ( PF 4 ) , which in combination are able to synergize , resulting in cell suppression at very low concentrations of these molecules . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Linkage of the interleukin 8 ( IL 8 ) , albumin ( ALB ) , and platelet factor 4 ( PF 4 ) genes was confirmed by NotI , SalI and SacII digests . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Based on observations of solubility and folding properties of peptide 33 mers derived from the beta sheet domains of platelet factor 4 ( PF 4 ) , interleukin 8 ( IL 8 ) , and growth related protein ( Gro alpha ) , as well as other beta sheet forming peptides , general guidelines have been developed to aid in the design of water soluble , self association induced beta sheet forming peptides . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Two other chemokines , interleukin 8 ( IL 8 ) and neutrophil activating peptide 2 ( NAP 2 ) , were also studied in comparison to PF 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| PF 4 binding has been shown to be independent of interleukin 8 receptors and could be inhibited by soluble chondroitin sulfate type glycosaminoglycans or by pretreatment of cells with chondroitinase ABC . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have examined PF 4 in comparison with interleukin 8 ( IL 8 ) for its ability to promote interaction of PMN with cultured endothelial cells ( EC ) . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Neutrophil gelatinase B potentiates interleukin 8 tenfold by aminoterminal processing , whereas it degrades CTAP 3 , PF 4 , and GRO alpha and leaves RANTES and MCP 2 intact . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Novel beta sheet forming peptide 33 mers , beta pep peptides , have been designed by using a combination approach employing basic folding principles and incorporating short sequences or proposed key residues from the beta sheet domains of interleukin 8 ( IL 8 ) , platelet factor 4 ( PF 4 ) and bactericidal / permeability increasing protein ( B / PI ) . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Using extracellular acidification rate to indicate transmembrane signaling , we find that interleukin 8 ( IL 8 ) , but not PF 4 , activates CD34+ progenitors , and PF 4 blocks IL 8 mediated activation . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| We have used NMR spectroscopy and molecular modeling to provide direct evidence that tetrameric platelet factor 4 ( PF 4 ) and dimeric interleukin 8 ( IL 8 ) , two members of the CXC chemokine family , readily interact by exchanging subunits and forming heterodimers via extension of their antiparallel beta sheet domains . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Subsequent photochemical treatment ( PCT ) with amotosalen and ultraviolet A light , and 7 days of storage , resulted in acceptable changes for platelet swirling , lactate , lactate dehydrogenase ( LDH ) , platelet factor 4 ( PF 4 ) , p selectin , glycoprotein 5 ( GpV ) , pO 2 , pCO 2 , tumour necrosis factor alpha ( TNF alpha ) and interleukin 8 ( IL 8 ) . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Structural analysis of this biologically active material by circular dichroism and fluorescence spectroscopy confirms that MIP 1 alpha has a very similar secondary and tertiary structure to platelet factor 4 and interleukin 8 with which it shares limited sequence homology . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Interleukin 8 ( IL 8 ) belongs to a family of small , structurally related cytokines similar to platelet factor 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Those human cytokines known as interleukin 8 , platelet factor 4 , beta thromboglobulin , IP 10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features , whereas the second subset consisting of LD 78 , ACT 2 , 1 309 , RANTES , and macrophage chemotactic and activating factor ( MCAF ) are all closely linked on human chromosome 17 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Monocyte derived neutrophil chemotactic factor ( MDNCF / IL 8 ) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily . ^^^ Monocyte derived neutrophil chemotactic factor ( MDNCF / IL 8 ) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| The deduced protein sequence showed homology ( 67 % identity , 77 % considering conservative amino acid changes ) with the human INF gamma inducible gene IP 10 , a member of the recently described superfamily of chemotactic and mitogenic proteins which includes platelet factor 4 , monocyte derived neutrophil chemotactic factor ( NAF , NAP 1 , IL 8 ) , and MGSA / gro / KC . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| These three human genes , MIP 2 alpha , MIP 2 beta , and gro / MGSA , constitute a sub family within the cytokine family represented by platelet factor 4 and interleukin 8 . . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NAP 2 , which belongs to the CXC family of chemokines that includes interleukin 8 and platelet factor 4 , binds to the interleukin 8 type 2 receptor and induces a rise in cytosolic calcium , chemotaxis of neutrophils , and exocytosis . ^^^ The overall tertiary structure , which is similar to that of platelet factor 4 and interleukin 8 , includes an extended amino terminal loop , three strands of antiparallel beta sheet arranged in a Greek key fold , and one alpha helix at the carboxyl terminus . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| To date , the three dimensional structures of two members of the alpha subfamily , interleukin 8 ( IL 8 ) and platelet factor 4 , and one member of the beta subfamily , human macrophage inflammatory protein 1 beta ( hMIP 1 beta ) , have been solved by either NMR or 10 ray crystallography . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| This observation led to predictions about the relative affinities of heparan sulfate for interleukin 8 and platelet factor 4 , predictions that were confirmed by further binding assays . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| The NAP 2 monomer consists of a triple stranded anti parallel beta sheet arranged in a ' Greek key ' and a C terminal helix ( residues 59 70 ) and is very similar to that found in the n . m . r . solution conformation of dimeric interleukin 8 and the crystal structure of tetrameric bovine platelet factor 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Comparison of 125I MGSA binding to the Duffy antigen and the human erythrocyte chemokine receptor showed that the specific 125I MGSA binding to both proteins was displaced by excess unlabeled MGSA , interleukin 8 , RANTES , monocyte chemotactic peptide 1 , and platelet factor 4 , but not by macrophage inflammatory protein 1 alpha or 1 beta . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Structurally , MGSA belongs to a superfamily of proteins that includes interleukin 8 ( IL 8 ) and platelet factor 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Transformation associated cytokine 9E3 / CEF4 is chemotactic for chicken peripheral blood mononuclear cells . 9E3 / CEF4 , which is released from transformed chicken embryo fibroblasts ( CEF ) , is a member of the platelet factor 4 family of inflammatory proteins and may be the avian homolog of interleukin 8 . ^^^ |
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| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| The ability to inhibit collagen expression was also demonstrated by another member of the C 10 C branch of the platelet factor 4 superfamily , interleukin 8 ( IL 8 ) , but not by RANTES , MIP 1 alpha , or MIP 1 beta , which belong to the C C branch . ^^^ |
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| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu Leu Arg . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| STUDY DESIGN AND METHODS : Analysis was done of pH and the levels of platelet factor 4 , beta thromboglobulin , interleukin 8 , RANTES , macrophage inflammatory protein 1 alpha , lactate dehydrogenase , and serotonin in the supernatant of stored PCs on Days 1 , 3 , 5 , and 8 . ^^^ |
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| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| The disulfide bonds have been identified by peptide mapping and sequence analysis , and are in the positions predicted by homology to interleukin 8 and platelet factor 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Lower interleukin 8 , platelet factor 4 , and monocyte chemotactic protein 1 levels were found in rPSGL Ig vein walls without significant differences in vein wall leukocyte morphometrics . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Platelet factor 4 induces human natural killer cells to synthesize and release interleukin 8 . ^^^ |
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| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Some cases of heparin induced thrombocytopenia ( HIT ) have been reported to be associated with antibodies against interleukin 8 ( IL 8 ) , a chemokine related to platelet factor 4 . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Peptides which would bind to leukocytes in vivo , such as antagonists to the tuftsin receptor , chemotactic peptides , interleukin 8 , or a platelet factor 4 analogue , have been radiolabeled for this purpose . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| Our findings suggest that both MIP 1 alpha and IP 10 mediate their suppressive effects in MO7e cells by stimulating increases in cellular cAMP levels and activating protein kinase A , a mechanism we believe to be unique to these chemokines and not one applied to all growth suppressive members of the chemokine superfamily ( for example , interleukin 8 and platelet factor 4 ) . . ^^^ |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02776 and P10145 |
Pubmed |
SVM Score :0.0 |
| NA |
|