Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.70973826
Quantitative analysis using the surface plasmon resonance based BIAcoreTM biosensor system confirms the extremely high affinity of PF 4 for heparin ( KD = 4 nM ) and shows that PF 4 binds to GAG+ thrombomodulin with a KD of 31 nM and to protein C with a KD of 0 . 37 microM . 0.70973826^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We find that the cationic platelet alpha granule protein platelet factor 4 ( PF 4 ) stimulates 4 25 fold the cofactor activity of rabbit TM and two differentially glycanated versions of an extracellular domain human TM polypeptide in which the glycosaminoglycan ( GAG ) is either present ( GAG+ TM ) or absent ( GAG TM ) with an ED 50 of 3 . 3 10 micrograms / ml . ^^^ PF 4 minimally affects the Kd for THR but decreases 30 fold ( from 8 . 3 to 0 . 3 microM ) the Km for protein C of APC generation by GAG+ TM . ^^^ PF 4 also strikingly transforms the [ Ca2+ ] dependence profile of rabbit and GAG+ TM to resemble that of GAG TM . ^^^ We conclude that PF 4 stimulates TM APC generation by interacting electrostatically with both the TM GAG and the protein C Gla domain to enhance markedly the affinity of the THR . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The values of plasma TM correlated neither with that of the platelet count nor with that of plasma beta TG or plasma PF 4 . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We determined plasma levels of molecular markers for platelet activity ( platelet factor 4 ; PF 4 , beta thromboglobulin ; beta TG ) , thrombotic status ( thrombin antithrombin 3 complex ; TAT , fibrinopeptide A ; FPA ) , fibrinolytic status ( plasmin alpha 2 plasmin inhibitor complex ; PIC , D dimer ) , and endothelial injury ( von Willebrand factor antigen ; vWF : Ag , thrombomodulin ; TM ) in 30 patients with Takayasu ' s arteritis and 20 age matched control subjects . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We sought evidence for changes in the following parameters : platelet count , von Willebrand factor antigen ( vWF : Ag ) and activity ( vWF activity ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , platelet activation markers ( GMP 140 and PAC 1 ) , activated partial thromboplastin time ( aPTT ) , prothrombin time ( PT ) , coagulant factor 8 ( FVIII : C ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , thrombomodulin ( TM ) and tissue plasminogen activator antigen ( tPA : Ag ) prior to G CSF and immediately before leukapheresis . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We evaluated the plasma free hemoglobin ( free Hb ) as an indication of hemolysis ; beta thromboglobulin ( beta TG ) and platelet factor four ( PF 4 ) as an indication of platelet deterioration ; C 3 , C 4 , CH 50 for complement activation ; coagulation parameters , fibrinolytic factor , thrombomodulin , nitric oxide ( NO ) , and endothelin as an indication of endothelial deterioration . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
METHODOLOGY : We evaluated laboratory data ( arterial blood gas ( pH , PaO 2 and PaCO 2 ) , pulmonary function tests ( % VC , FEV1 / FVC and % DL ( CO ) ) , mean pulmonary arterial pressure ( mPAP ) , white blood cell count , C reactive protein and the plasma levels of fibrinopeptide A ( FPA ) , beta thrombogloblin ( beta TG ) , platelet factor 4 ( PF 4 ) and thrombomodulin ( TM ) ) before and after SH administration . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We evaluated the plasma free hemoglobin ( fHb ) as the hemolysis parameter , beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) as the platelet deterioration index , C 3 , C 4 , and CH 50 as complement activation , coagulation function , fibrinolytic factor and thrombomodulin , nitric oxide ( NO ) , and endothelin as endothelial deterioration . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
BACKGROUND : Urinary 11 dehydrothromboxane B ( 2 ) / creatinine ( 11 DTXB ( 2 ) / Cr ) is a marker for in vivo platelet activation and vascular constriction , blood thrombomodulin ( TM ) for endothelial damage and associated thrombosis , thrombin antithrombin complex ( TAT ) for thrombin formation , and beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) for in vivo platelet activation and releasing reaction . ^^^ Urinary and circulating blood levels of 11 DTXB ( 2 ) / Cr , TM , TAT , beta TG , and PF 4 were measured simultaneously . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
To study this , a cross sectional comparison of the plasma levels of thrombomodulin ( TM ) , platelet factor 4 ( PF 4 ) , beta thromboglobulin ( beta TG ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) and total degradation products of fibrin ( ogen ) ( TDP ) was made between 5 ET patients suffering from erythromelalgia , 16 asymptomatic ET patients and 20 control subjects , and after treatment with aspirin , respectively . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The mutual correlation of parameters with calcium dependent release ( vWF , platelet factor PF 4 and C peptide ) was confirmed in the group of patients with NIDDM with normal TM values and in the group of blood donors . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Plasma levels of P selectin , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , thrombomodulin , protein S and activity of protein C were compared between the two groups , and the relationships between these indices and hematocrit value were evaluated . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The substantially reduced activation of blood coagulation ( TAT ) for TM coated samples correlates well with the degree of contact activation ( bradykinin and FXIIa formation ) while no significant effects were observed for the platelet activation ( PF 4 ) . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Urinary 11 dehydrothromboxane B2 / creatinine ( 11 DTXB2 / Cr ) is a marker for platelet activation and vascular constriction , thrombin antithrombin complex ( TAT ) for thrombin formation , serum thrombomodulin ( TM ) for endothelial damage , and beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) for platelet activation and releasing reaction . ^^^ The TM , beta TG , and PF 4 levels were increased significantly ( P < 0 . 05 0 . 01 ) in group 4 compared to those in groups 1 , 2 , and 3 . ^^^ In contrast , endothelial damage ( determined by TM ) and platelet release of PF 4 may not increase significantly in group 2 , but they may increase in group 4 . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Platelet factor 4 ( PF 4 ) , an abundant platelet alpha granule protein , accelerates in vitro generation of activated protein C ( APC ) by soluble thrombin / thrombomodulin ( TM ) complexes up to 25 fold . ^^^ To test the hypothesis that PF 4 similarly stimulates endothelium associated TM , we assessed the influence of human PF 4 on thrombin dependent APC generation by cultured endothelial monolayers . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic , thrombotic signs and symptoms , correction of the shortened platelet survival times , and a significant reduction of the increased levels of beta TG , PF 4 , TM and urinary TxB 2 excretion to normal . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
OBJECTIVE : To review published studies of the influence of platelet factor 4 ( PF 4 ) and other cationic proteins on the generation of activated protein C ( APC ) by the thrombomodulin protein C system . ^^^ DATA SOURCE : Using the PubMed citation index , literature published from 1973 to 2003 regarding cationic proteins , PF 4 , and the thrombomodulin protein C system was reviewed . ^^^ DATA SYNTHESIS : All other cationic proteins studied to date either impair or do not affect APC generation via the thrombomodulin protein C system ; however , the platelet alpha granule protein PF 4 causes a 25 fold increase in the ability of thrombomodulin polypeptides to generate APC and a ten fold increase in the ability of cultured endothelial cell associated thrombomodulin to generate APC . ^^^ The extent of PF 4 ' s stimulation of APC generation is further increased by its interaction with the anionic glycosaminoglycan moiety that is variably expressed through posttranslational , O linked glycosylation of thrombomodulin . ^^^ In an in vivo thrombin infusion model of thrombomodulin activation in cynomolgus monkeys , previous intravenous infusion of pharmacologic amounts of PF 4 resulted in circulating APC levels and APC dependent prolongation of activated partial thromboplastin times that were two to three fold greater than those observed in saline infused control animals . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
ET patients with microvascular disturbances have shortened platelet survival , increased beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , and thrombomodulin ( TM ) levels , and increased urinary thromboxane B 2 ( TXB 2 ) excretion , indicating platelet mediated thrombotic processes . ^^^ Inhibition of platelet cyclooxygenase 1 by aspirin is followed by relief of microvascular disturbances ; correction of shortened platelet survival ; correction of increased plasma beta TG , PF 4 , and TM levels ; and correction of increased TXB 2 excretion to normal . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Platelet count , hematocrit , antithrombin 3 ( ATIII ) , beta thromboglobulin , platelet factor 4 , fibrinopeptide A , thrombin antithrombin 3 complex , FDP , D dimer FDP , plasmin alpha 2 plasmin inhibitor complex , tissue plasminogen activator ( t PA ) , and thrombomodulin ( TM ) were measured through the operation up to two weeks after surgery . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The effects on these activities of mouse anti thrombomodulin monoclonal antibodies and of the heparin neutralizing proteins , platelet factor 4 , histidine rich glycoprotein , and S protein , were investigated . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex and fibrinopeptide A were tested for coagulation , platelet factor 4 and beta thromboglobulin for platelet activation , glycoprotein IIb IIIa , glycoprotein Ib and P selectin for platelet membrane glycoproteins , D dimers for fibrinolysis , thrombomodulin for activation of endothelial cells and thrombospondin and von Willebrand factor for adhesive proteins . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
In particular , we describe tissue factor , tissue factor pathway inhibitor , prothrombin fragment 1 . 2 , thrombin antithrombin complex , fibrinopeptide A , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI complex , Bbeta 15 42 related peptides , fibrinogen degradation products , fibrin degradation products , D dimer , platelet factor 4 , beta thromboglobulin , 5 hydroxytryptamine , thromboxane B 2 , prostacyclin , endothelin , angiotensin converting enzyme , soluble thrombomodulin , C 1 esterase inhibitor , anaphylotoxins C3a , C4a , and C5a , bradykinin , tumor necrosis factor , leukotriene C 4 , platelet activating factor , anti phospholipid antibody , and von Willebrand factor . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Standard coagulation data and molecular markers of coagulation activation and fibrinolytic activity ( soluble thrombomodulin , protein C , free protein S , thrombin / antithrombin 3 complex , plasmin alpha 2 antiplasmin complex , tissue plasminogen activator , platelet factor 4 , beta thromboglobulin were measured from arterial blood samples on the day of admission to the intensive care unit ( trauma / neurosurgery patients ) or on the day of diagnosis of sepsis ( baseline value ) and serially during the next 5 days . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
We assessed fibrinogen , antithrombin 3 , protein C , markers of platelet activation ( platelet factor 4 and beta thromboglobulin ) as markers of fibrinolysis , and D dimer , tissue plasminogen activator , plasminogen activator inhibitor , von Willebrand ' s factor and soluble thrombomodulin as endothelial dysfunction . ^^^ Plasma fibrinogen ( P < 0 . 005 ) , platelet factor 4 ( P < 0 . 001 ) , thromboglobulin ( P < 0 . 001 ) , D dimer ( P < 0 . 03 ) , tissue plasminogen activator ( P < 0 . 006 ) , plasminogen activator inhibitor ( P < 0 . 04 ) and both von Willebrand ' s factor ( P < 0 . 0001 ) and soluble thrombomodulin ( P < 0 . 03 ) were significantly higher in the patients than in the controls . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
Arterial blood gases , pulmonary function , mean pulmonary arterial pressure , left ventricular ejection fraction ( LVEF ) , right ventricular ejection fraction ( RVEF ) , white blood cell count , C reactive protein and the plasma concentrations of fibrinopeptide A , beta thromboglobulin , platelet factor 4 and thrombomodulin were evaluated before and 2 and 12 months after SH administration . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The new molecular markers recently introduced can show the existence of a preclinical state of blood activation at the plasma level ( fibrinopeptide A , thrombin antithrombin complexes , modified antithrombin 3 , fragments 1 + 2 of prothrombin , D dimer ) or at the platelet level ( B thromboglobulin , platelet factor 4 , and thrombospondin ) , and promising developments concern the endothelial level ( soluble thrombomodulin ) . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The genes considered are ; alpha fibrinogen , beta fibrinogen , gamma fibrinogen , prothrombin , tissue factor , factor 5 , protein S , complement component 4 binding protein , factor 11 , factor 12 , factor XIIIa , factor XIIIb , histidine rich glycoprotein , high molecular weight kininogen , kallikrein , von Willebrands factor , platelet factor 4 , thrombospondin , antithrombin 3 , alpha 1 antitrypsin , thrombomodulin , plasminogen , tissue plasminogen activator , urokinase plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , protein C inhibitor , alpha 2 plasmin inhibitor , kallistatin , lipoprotein a , interleukin 6 , interleukin 1 , cystathionine beta synthase , and methylenetetrahydrofolate reductase . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
The main outcome measures were N 3 fatty acid proportions of platelet lipids , transcapillary escape rate of albumin , prothrombin fragment 1 + 2 , thrombin antithrombin complexes , markers of fibrinolysis , fibrinogen , factor 7 antigen and activity , thrombomodulin , von Willebrand factor , platelet factor 4 and beta thromboglobulin . ^^^
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02776 and P07204	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.70973826
Quantitative analysis using the surface plasmon resonance based BIAcoreTM biosensor system confirms the extremely high affinity of PF 4 for heparin ( KD = 4 nM ) and shows that PF 4 binds to GAG+ thrombomodulin with a KD of 31 nM and to protein C with a KD of 0 . 37 microM . 0.70973826^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex and fibrinopeptide A were tested for coagulation , platelet factor 4 and beta thromboglobulin for platelet activation , glycoprotein IIb IIIa , glycoprotein Ib and P selectin for platelet membrane glycoproteins , D dimers for fibrinolysis , thrombomodulin for activation of endothelial cells and thrombospondin and von Willebrand factor for adhesive proteins . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
We determined plasma levels of molecular markers for platelet activity ( platelet factor 4 ; PF 4 , beta thromboglobulin ; beta TG ) , thrombotic status ( thrombin antithrombin 3 complex ; TAT , fibrinopeptide A ; FPA ) , fibrinolytic status ( plasmin alpha 2 plasmin inhibitor complex ; PIC , D dimer ) , and endothelial injury ( von Willebrand factor antigen ; vWF : Ag , thrombomodulin ; TM ) in 30 patients with Takayasu ' s arteritis and 20 age matched control subjects . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The new molecular markers recently introduced can show the existence of a preclinical state of blood activation at the plasma level ( fibrinopeptide A , thrombin antithrombin complexes , modified antithrombin 3 , fragments 1 + 2 of prothrombin , D dimer ) or at the platelet level ( B thromboglobulin , platelet factor 4 , and thrombospondin ) , and promising developments concern the endothelial level ( soluble thrombomodulin ) . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
To study this , a cross sectional comparison of the plasma levels of thrombomodulin ( TM ) , platelet factor 4 ( PF 4 ) , beta thromboglobulin ( beta TG ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) and total degradation products of fibrin ( ogen ) ( TDP ) was made between 5 ET patients suffering from erythromelalgia , 16 asymptomatic ET patients and 20 control subjects , and after treatment with aspirin , respectively . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
In particular , we describe tissue factor , tissue factor pathway inhibitor , prothrombin fragment 1 . 2 , thrombin antithrombin complex , fibrinopeptide A , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI complex , Bbeta 15 42 related peptides , fibrinogen degradation products , fibrin degradation products , D dimer , platelet factor 4 , beta thromboglobulin , 5 hydroxytryptamine , thromboxane B 2 , prostacyclin , endothelin , angiotensin converting enzyme , soluble thrombomodulin , C 1 esterase inhibitor , anaphylotoxins C3a , C4a , and C5a , bradykinin , tumor necrosis factor , leukotriene C 4 , platelet activating factor , anti phospholipid antibody , and von Willebrand factor . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Platelet count , hematocrit , antithrombin 3 ( ATIII ) , beta thromboglobulin , platelet factor 4 , fibrinopeptide A , thrombin antithrombin 3 complex , FDP , D dimer FDP , plasmin alpha 2 plasmin inhibitor complex , tissue plasminogen activator ( t PA ) , and thrombomodulin ( TM ) were measured through the operation up to two weeks after surgery . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The effects on these activities of mouse anti thrombomodulin monoclonal antibodies and of the heparin neutralizing proteins , platelet factor 4 , histidine rich glycoprotein , and S protein , were investigated . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Platelet factor 4 stimulates thrombomodulin protein C activating cofactor activity . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
We assessed fibrinogen , antithrombin 3 , protein C , markers of platelet activation ( platelet factor 4 and beta thromboglobulin ) as markers of fibrinolysis , and D dimer , tissue plasminogen activator , plasminogen activator inhibitor , von Willebrand ' s factor and soluble thrombomodulin as endothelial dysfunction . ^^^ Plasma fibrinogen ( P < 0 . 005 ) , platelet factor 4 ( P < 0 . 001 ) , thromboglobulin ( P < 0 . 001 ) , D dimer ( P < 0 . 03 ) , tissue plasminogen activator ( P < 0 . 006 ) , plasminogen activator inhibitor ( P < 0 . 04 ) and both von Willebrand ' s factor ( P < 0 . 0001 ) and soluble thrombomodulin ( P < 0 . 03 ) were significantly higher in the patients than in the controls . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
We sought evidence for changes in the following parameters : platelet count , von Willebrand factor antigen ( vWF : Ag ) and activity ( vWF activity ) , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , platelet activation markers ( GMP 140 and PAC 1 ) , activated partial thromboplastin time ( aPTT ) , prothrombin time ( PT ) , coagulant factor 8 ( FVIII : C ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , thrombomodulin ( TM ) and tissue plasminogen activator antigen ( tPA : Ag ) prior to G CSF and immediately before leukapheresis . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
We evaluated the plasma free hemoglobin ( free Hb ) as an indication of hemolysis ; beta thromboglobulin ( beta TG ) and platelet factor four ( PF 4 ) as an indication of platelet deterioration ; C 3 , C 4 , CH 50 for complement activation ; coagulation parameters , fibrinolytic factor , thrombomodulin , nitric oxide ( NO ) , and endothelin as an indication of endothelial deterioration . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Standard coagulation data and molecular markers of coagulation activation and fibrinolytic activity ( soluble thrombomodulin , protein C , free protein S , thrombin / antithrombin 3 complex , plasmin alpha 2 antiplasmin complex , tissue plasminogen activator , platelet factor 4 , beta thromboglobulin were measured from arterial blood samples on the day of admission to the intensive care unit ( trauma / neurosurgery patients ) or on the day of diagnosis of sepsis ( baseline value ) and serially during the next 5 days . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
METHODOLOGY : We evaluated laboratory data ( arterial blood gas ( pH , PaO 2 and PaCO 2 ) , pulmonary function tests ( % VC , FEV1 / FVC and % DL ( CO ) ) , mean pulmonary arterial pressure ( mPAP ) , white blood cell count , C reactive protein and the plasma levels of fibrinopeptide A ( FPA ) , beta thrombogloblin ( beta TG ) , platelet factor 4 ( PF 4 ) and thrombomodulin ( TM ) ) before and after SH administration . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
We evaluated the plasma free hemoglobin ( fHb ) as the hemolysis parameter , beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) as the platelet deterioration index , C 3 , C 4 , and CH 50 as complement activation , coagulation function , fibrinolytic factor and thrombomodulin , nitric oxide ( NO ) , and endothelin as endothelial deterioration . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Plasma levels of P selectin , beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , thrombomodulin , protein S and activity of protein C were compared between the two groups , and the relationships between these indices and hematocrit value were evaluated . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Arterial blood gases , pulmonary function , mean pulmonary arterial pressure , left ventricular ejection fraction ( LVEF ) , right ventricular ejection fraction ( RVEF ) , white blood cell count , C reactive protein and the plasma concentrations of fibrinopeptide A , beta thromboglobulin , platelet factor 4 and thrombomodulin were evaluated before and 2 and 12 months after SH administration . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The genes considered are ; alpha fibrinogen , beta fibrinogen , gamma fibrinogen , prothrombin , tissue factor , factor 5 , protein S , complement component 4 binding protein , factor 11 , factor 12 , factor XIIIa , factor XIIIb , histidine rich glycoprotein , high molecular weight kininogen , kallikrein , von Willebrands factor , platelet factor 4 , thrombospondin , antithrombin 3 , alpha 1 antitrypsin , thrombomodulin , plasminogen , tissue plasminogen activator , urokinase plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , protein C inhibitor , alpha 2 plasmin inhibitor , kallistatin , lipoprotein a , interleukin 6 , interleukin 1 , cystathionine beta synthase , and methylenetetrahydrofolate reductase . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The main outcome measures were N 3 fatty acid proportions of platelet lipids , transcapillary escape rate of albumin , prothrombin fragment 1 + 2 , thrombin antithrombin complexes , markers of fibrinolysis , fibrinogen , factor 7 antigen and activity , thrombomodulin , von Willebrand factor , platelet factor 4 and beta thromboglobulin . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
BACKGROUND : Urinary 11 dehydrothromboxane B ( 2 ) / creatinine ( 11 DTXB ( 2 ) / Cr ) is a marker for in vivo platelet activation and vascular constriction , blood thrombomodulin ( TM ) for endothelial damage and associated thrombosis , thrombin antithrombin complex ( TAT ) for thrombin formation , and beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) for in vivo platelet activation and releasing reaction . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Urinary 11 dehydrothromboxane B2 / creatinine ( 11 DTXB2 / Cr ) is a marker for platelet activation and vascular constriction , thrombin antithrombin complex ( TAT ) for thrombin formation , serum thrombomodulin ( TM ) for endothelial damage , and beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) for platelet activation and releasing reaction . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic , thrombotic signs and symptoms , correction of the shortened platelet survival times , and a significant reduction of the increased levels of beta TG , PF 4 , TM and urinary TxB 2 excretion to normal . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
OBJECTIVE : To review published studies of the influence of platelet factor 4 ( PF 4 ) and other cationic proteins on the generation of activated protein C ( APC ) by the thrombomodulin protein C system . ^^^ DATA SOURCE : Using the PubMed citation index , literature published from 1973 to 2003 regarding cationic proteins , PF 4 , and the thrombomodulin protein C system was reviewed . ^^^ DATA SYNTHESIS : All other cationic proteins studied to date either impair or do not affect APC generation via the thrombomodulin protein C system ; however , the platelet alpha granule protein PF 4 causes a 25 fold increase in the ability of thrombomodulin polypeptides to generate APC and a ten fold increase in the ability of cultured endothelial cell associated thrombomodulin to generate APC . ^^^ The extent of PF 4 ' s stimulation of APC generation is further increased by its interaction with the anionic glycosaminoglycan moiety that is variably expressed through posttranslational , O linked glycosylation of thrombomodulin . ^^^ In an in vivo thrombin infusion model of thrombomodulin activation in cynomolgus monkeys , previous intravenous infusion of pharmacologic amounts of PF 4 resulted in circulating APC levels and APC dependent prolongation of activated partial thromboplastin times that were two to three fold greater than those observed in saline infused control animals . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
ET patients with microvascular disturbances have shortened platelet survival , increased beta thromboglobulin ( beta TG ) , platelet factor 4 ( PF 4 ) , and thrombomodulin ( TM ) levels , and increased urinary thromboxane B 2 ( TXB 2 ) excretion , indicating platelet mediated thrombotic processes . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The values of plasma TM correlated neither with that of the platelet count nor with that of plasma beta TG or plasma PF 4 . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The mutual correlation of parameters with calcium dependent release ( vWF , platelet factor PF 4 and C peptide ) was confirmed in the group of patients with NIDDM with normal TM values and in the group of blood donors . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
Platelet factor 4 ( PF 4 ) , an abundant platelet alpha granule protein , accelerates in vitro generation of activated protein C ( APC ) by soluble thrombin / thrombomodulin ( TM ) complexes up to 25 fold . ^^^ To test the hypothesis that PF 4 similarly stimulates endothelium associated TM , we assessed the influence of human PF 4 on thrombin dependent APC generation by cultured endothelial monolayers . ^^^ Platelet factor 4 ( PF 4 ) , an abundant platelet alpha granule protein , accelerates in vitro generation of activated protein C ( APC ) by soluble thrombin / thrombomodulin ( TM ) complexes up to 25 fold . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
The substantially reduced activation of blood coagulation ( TAT ) for TM coated samples correlates well with the degree of contact activation ( bradykinin and FXIIa formation ) while no significant effects were observed for the platelet activation ( PF 4 ) . ^^^
Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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Interacting proteins: P07204 and P02776	Pubmed	SVM Score :0.0
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