| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.55193186 |
| Interactions of myocilin with molecules such as fibronectin and fibrillin 1 were confirmed biochemically . 0.55193186^^^ Myocilin was found to associate mainly with the sheath material , overlapping extensively in distribution with fibronectin , fibrillin 1 , and MAGP 1 and moderately with decorin and type 6 collagen . 0.55061692^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.50041712 |
| Using myocilin produced in sf 9 insect cells , myocilin inhibited spreading of cycloheximide treated human skin fibroblasts plated on substrates co coated with myocilin and either fibronectin or its Heparin 2 domain . 0.50041712^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| Myocilin binds specifically to the HepII domain of fibronectin . ^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies against myocilin and other ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , hyaluronic acid , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^ Myocilin predominantly localized in the long spacing collagens and sheath materials surrounding elastic like fibers , codistributed with fibronectin , fibrillin 1 , MAGP 1 , decorin , and type 6 collagen . ^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| Cell adhesion assays indicated that TM cells , while adhering readily on fibronectin , failed to attach on recombinant myocilin purified from bacterial cultures . ^^^ Adhesion on fibronectin was also compromised by myocilin in a dose dependent manner . ^^^ TM cell migration on fibronectin / myocilin to scratched wounds was reduced compared to fibronectin controls . ^^^ Cell attachment on fibronectin and migration of corneal fibroblasts , a control cell type , were not altered by myocilin . ^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| Overexpression of GRbeta in glaucomatous TM cells inhibited DEX induction of a luciferase reporter gene as well as the endogenous genes MYOC and fibronectin . ^^^ Overexpression of GRbeta was conducted in glaucomatous TM cell lines , and the regulation of GRbeta in the Dex induced reporter gene luciferase or endogenous myocilin and fibronectin expression were determined . ^^^ |
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| Interacting proteins: P02751 and Q99972 |
Pubmed |
SVM Score :0.0 |
| The morphology and adhesion of human TM cells plated either on fibronectin alone or on fibronectin / purified myocilin mixtures were assessed by phase contrast microscopy . ^^^ Cell adhesion was impaired and microspikes were formed when TM cells were plated onto fibronectin / bacterial full length myocilin mixtures . ^^^ |
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