| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :1.1621713 |
| Furthermore , we show that MIA interacts with fibronectin and that the peptide ligands identified for MIA exhibit a matching sequence to type 3 human fibronectin repeats , especially to FN 14 , which is close to an integrin alpha4beta1 binding site . 1.1621713^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| MIA ( melanoma inhibitory activity ) has been identified as a small protein secreted from malignant melanoma cells , which interacts with extracellular matrix proteins including fibronectin . ^^^ |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| In vitro and in vivo experiments using recombinant MIA protein revealed that MIA specifically inhibits attachment of melanoma cells to fibronectin and laminin . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| The aims of our study were to ascertain whether epidermal growth factor ( EGF ) , transforming growth factor beta 1 ( TGF beta 1 ) , interleukin 1alpha ( IL 1alpha ) , or interleukin 1beta ( IL 1beta ) can modify MIA PaCa 2 ( pancreatic cancer cell line ) and CAPAN 1 ( metastatic pancreatic cancer cell line ) adhesion to fibronectin , laminin , or type 1 collagen , and whether these cytokines can shift the membrane expression of the hyaluronic acid receptor ( CD 44 ) . ^^^ EGF significantly enhanced MIA PaCa 2 , but not CAPAN 1 , adhesion to fibronectin , laminin , and type 1 collagen . ^^^ TGF beta 1 reduced MIA PaCa 2 adhesion to type 1 collagen , but enhanced CAPAN 1 adhesion to fibronectin and laminin . ^^^ IL 1alpha was found to enhance MIA PaCa 2 adhesion to fibronectin , while reducing adhesion to type 1 collagen , whereas IL 1beta reduced the adhesion to laminin . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recent results revealed a direct interaction of MIA and epitopes within extracellular matrix proteins including fibronectin . ^^^ Here we show that MIA interferes specifically with attachment of melanoma cells to fibronectin , a phenomenon we refer to as active detachment . ^^^ Antibodies inhibiting binding of alpha4beta1 and alpha5beta1 integrins to fibronectin cross react specifically with MIA , suggesting that MIA shares significant structural homology with the binding pockets of these integrins and thereby masks the respective epitopes on extracellular matrix molecules . ^^^ Several peptides derived from fibronectin and from a phage display screening were tested with respect to a potential MIA inhibitory effect . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| MIA is a potent melanoma detachment factor that interferes with cellular adherence by binding to fibronectin and laminin , blocking their interaction with alpha4beta1 and alpha5beta1 integrins . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| Further , both cancer cDNA array and protein arrays verified a marked downregulation of several other melanoma associated genes ( e . g . membrane type 1 matrix metalloproteinase tissue type plasminogen activator integrin beta 3 , secreted protein acidic and rich in cysteins and fibronectin ) in the MIA deficient melanoma cells , confirmed by real time RT PCR and Western blotting . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| To investigate whether the ECM may further contribute to abnormalities in the microenvironment by influencing IL 8 secretion , we cultured the Mia PaCa 2 pancreatic carcinoma cell line on fibronectin . ^^^ |
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| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recent studies revealed an interaction of MIA with epitopes of extracellular matrix proteins including fibronectin . ^^^ |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16674 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|