| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| The FN associated FasL stops the CXCL 12 ( stromal cell derived factor 1alpha ) induced chemotaxis of T cells by inhibiting the chemokine induced extracellular signal regulated kinase signaling and cytoskeletal rearrangement . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , 3S DS inhibited CXC chemokine ligand 12 ( CXCL 12 ; stromal cell derived factor 1alpha ) dependent migration in vitro and in vivo and decreased CXCL 12 induced T cell adhesion to the extracellular matrix glycoprotein , fibronectin ( FN ) . ^^^ Despite inhibiting CXCL 12 induced adhesion , 3S DS , on its own , induced T cell adhesion to FN , which was accompanied by phosphorylation of Pyk 2 . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Complementing these observations were others indicating that over 50 % of LIL express CXCR 4 and , in response to CXCL 12 , migrated and adhered to fibronectin . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We found that allicin ( 20 100 microm ) inhibits the SDF 1alpha ( CXCL 12 ) induced T cell migration through fibronectin ( FN ) , and that this inhibition is mediated by the down regulation of ( 1 ) the reorganization of cortical actin and the subsequent T cell polarization , and ( 2 ) T cell adhesion to FN . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| HNSCC cell adhesion to fibronectin and collagen was increased by CXCL 12 treatment , while the addition of an inhibitor of ERK 1 / 2 signaling , PD 98059 , reduced the effects of CXCL 12 . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Altered thymocyte migration during experimental acute Trypanosoma cruzi infection : combined role of fibronectin and the chemokines CXCL 12 and CCL 4 . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We examined CXCR 4 expression and functionality , and explored CXCL 12 triggered adhesion of prostate tumor cells to human endothelium or to extracellular matrix proteins laminin , collagen , and fibronectin . ^^^ CXCL 12 induced elevated adhesion to the endothelial cell monolayer and to immobilized fibronectin , laminin , and collagen . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| It was also found that SDF 1 induced chemotaxis of progenitors can occur in the presence of fibronectin ( FN ) and extracellular matrix components and that FN effects involve activation of beta 1 , and possibly alpha 4 , integrins . . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| SDF 1 suppresses cytokine induced adhesion of human haemopoietic progenitor cells to immobilized fibronectin . ^^^ We assessed the effects of SDF 1 on cytokine induced adhesion of progenitor cells to fibronectin . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Coating of the filters with the extracellular matrix protein fibronectin ( FN ) strongly enhanced the SDF 1 induced migration of PB CD34+ cells ( 2 . 5 times ) and of BM CD34+ cells ( 1 . 5 times ) . ^^^ SDF 1 induced migration of PB CD34+ cells over FN coated filters was blocked by antibodies against beta 1 integrins . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We found SDF 1 on synovial endothelial cells and showed that SDF 1 was able to induce strong integrin mediated adhesion of synovial fluid T cells to fibronectin and ICAM 1 , confirming that CXCR 4 expressed on synovial T cells was functional . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Presentation of chemokine SDF 1 alpha by fibronectin mediates directed migration of T cells . ^^^ The chemokine SDF 1 alpha binds fibronectin ( Fn ) with a low nanomolar K ( d ) ( equilibrium dissociation constant ) . ^^^ SDF 1 alpha presented by Fn induced directed migration . ^^^ Fn presented chemokine induced the polarization of cells , including the redistribution of the SDF 1 alpha receptor , to the basal surface and leading edge of the cell . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We found that A ) SDF 1 , after binding to CXCR 4 , activates multiple signaling pathways and that in comparison with the MIP 1beta CCR 5 axis , plays a privileged role in hematopoiesis ; B ) SDF 1 activation of the MAPK p42 / 44 pathway and the PI 3K AKT axis does not affect proliferation and apoptosis but modulates integrin mediated adhesion to fibronectin , and C ) SDF 1 induces secretion of VEGF , but not of MMPs or TIMPs . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Treatment with SDF 1 of NALM 6 cells or cells from cases of precursor B ALL resulted in a doubling of adhesion to fibronectin , laminin , and VCAM 1 , but had no effect on binding to collagens 1 or 4 . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| The presence of the extracellular matrix protein fibronectin ( FN ) strongly enhanced the spontaneous and SDF 1 induced migration of leukemic PB and BM cells . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Accordingly , we found that , although SDF 1 did not affect proliferation or survival of these cell lines , it induced in several of them ( 1 ) phosphorylation of mitogen activated protein kinase p42 / 44 ; ( 2 ) locomotion ; ( 3 ) directional chemotaxis across membranes covered by laminin , fibronectin , or Matrigel ; ( 4 ) adhesion to laminin , fibronectin , and endothelial cells ; and ( 5 ) increased MMP 2 and diminished tissue inhibitors of metalloproteinases secretion . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| In Jurkat T cells , adhesion to the immobilized alpha 4 beta 1 integrin ligand VCAM 1 or to the alpha 5 beta 1 integrin ligand fibronectin regulated stromal cell derived factor 1 ( SDF 1 ) activation of ERK . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Stromal cell derived factor 1 ( SDF 1 ) 100 ng / ml was added into the experimental CD 34 ( + ) cells and the absorbance at 570 nm of all groups was examined . 20 micro g / ml fibronectin ( Fn ) was added and the spontaneous adhesion between CD 34 ( + ) and FN was detected by MTT method . ^^^ RESULTS : ( 1 ) The expression of CD49d , CD 44 , CD11a and CD49e on expanded CD 34 ( + ) cells increased or sustained the same levels as those of the fresh isolated UCB CD 34 ( + ) cells , while the expression of CD62L , CD 54 and CD 31 on expanded CD 34 ( + ) cells declined during the culture . ( 2 ) The spontaneous adhesion between CD 34 ( + ) and FN and SDF 1 induced adhesion continuously increased in the course of the first 10 day culture . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We found that SDF 1 enhanced EPC number by promoting alpha ( 2 ) , alpha ( 4 ) , and alpha ( 5 ) integrin mediated adhesion to fibronectin and collagen 1 . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| We found that supernatants of leukapheresis products ( SLPs ) of patients mobilized with granulocyte colony stimulating factor ( G CSF ) or the various components of SLPs ( fibrinogen , fibronectin , soluble vascular cell adhesion molecule 1 [ VCAM 1 ] , intercellular adhesion molecule 1 [ ICAM 1 ] , and urokinase plasminogen activator receptor [ uPAR ] ) increase the chemotactic responses of hematopoietic stem / progenitor cells ( HSPCs ) to stromal derived factor 1 ( SDF 1 ) . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| On fibronectin , SDF 1 stimulated chemotaxis involved both alpha4beta1 and alpha5beta1 integrins . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| Th 1 lymphocytes adhere transiently to the extracellular matrix ligands laminin 1 and fibronectin in response to chemokines such as RANTES and stromal cell derived factor 1 , and this process is paralleled by the activation of the Rac 1 GTPase and by a rapid burst of actin polymerization . ^^^ |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|