| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.57208201 |
| Heparan sulfate proteoglycan ( HSPG ) , for example , associates with several matrix components such as fibronectin , laminin , and basic fibroblast growth factor . 0.57208201^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Significant increases in mRNA for fibronectin ( 7 . 5 fold , P < 0 . 01 ) , heparan sulfate proteoglycan core protein ( 53 fold , P < 0 . 001 ) , laminin beta 1 ( 12 fold , P < 0 . 001 ) , collagen alpha 1 ( 4 ) ( 17 fold , P < 0 . 001 ) , collagen alpha 1 ( 3 ) ( fourfold , P < 0 . 001 ) , and MMP 9 ( twofold , P < 0 . 05 ) were observed after perfusion with TGF beta 1 . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We have studied the distribution of fibronectin , laminin , heparan sulfate proteoglycan ( HSPG ) and collagen types 1 , 3 and 4 , along with the platelet alpha granule glycoprotein , thrombospondin ( TSP ) , by immunofluorescence in frozen sections of muscle from control denervating conditions and ALS patients . ^^^ We found no marked quantitative or qualitative differences in the distribution of collagen types 1 , 3 and 4 , laminin , fibronectin or HSPG in ALS patients compared to controls . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The 1G10 antigen is also expressed by cultured mesangial cells , but not by cultured glomerular epithelial cells , umbilical endothelial cells or fibroblasts . 1G10 did not react with the mesangial matrix proteins [ fibronectin ( FN ) , laminin ( LAM ) , collagen types 1 , 3 , 4 , 5 , and 6 ( Col 1 , 3 , 4 , 5 , 6 ) , heparin sulfate proteoglycan ( HSPG ) , or thrombospondin ( TS ) ] present under normal and diseased states or smooth muscle antigens ( myosin , actin ) , but did react with a 4 M urea extract of renal cortex and a 0 . 3 % deoxycholate extract of isolated glomeruli . ^^^ On one dimensional immunoblot this band did not show cross react with polyclonal antisera to FN , LAM , Col 4 , 5 , 6 , HSPG or TS . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Cell surface heparan sulfate proteoglycan ( HSPG ) from metastatic mouse melanoma cells initiates cell adhesion to the synthetic peptide FN C / H 2 , a heparin binding peptide from the 33 kD A chain derived fragment of fibronectin . ^^^ The involvement of mouse melanoma cell surface HSPG in cell adhesion to fibronectin was also demonstrated by the ability of anti HSPG antibodies and anti HSPG IgG Fab monomers to inhibit mouse melanoma cell adhesion to FN C / H 2 . 35S HSPG and 35S HS bind to FN C / H 2 affinity columns and require 0 . 25 M NaCl for elution . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Furthermore , antibodies generated against a mouse melanoma HS proteoglycan ( HSPG ) inhibited B 104 cell adhesion to FN C / H 2 and the 33 / 66 kDa FN fragments . 35S HSPG isolated from B 104 cells directly bound to FN C / H 2 both in solid phase assays and by affinity chromatography , but failed to bind to a control peptide from this region , CS 1 . ^^^ These results identify a cell surface HSPG that likely mediates neuronal cell binding interactions with FN C / H II . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In the present report we analyzed the presence and distribution of various basement membrane ( BM ) proteins in normal blood and lymph vessels with special emphasis on BM associated heparan sulfate proteoglycan ( HSPG ) when compared to the BM components collagen 4 , laminin and fibronectin . ^^^ We found that normal lymph capillaries have a BM that contains only collagen 4 and small amounts of laminin , but almost no BM associated HSPG and fibronectin , while blood capillaries showed a BM comprising of all components tested for . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The immunohistochemical localization of the extracellular matrix was examined in 31 cases with different degrees of human diabetic nephropathy using antisera to human collagen types 1 , 3 , 4 , 5 , fibronectin , laminin , and basement membrane associated heparan sulfate proteoglycan ( HSPG ) . ^^^ In diabetic diffuse glomerulosclerosis , the enlarged mesangial matrix showed an increased staining reaction for collagen 4 , 5 , laminin , and fibronectin whereas the staining pattern of HSPG was markedly reduced . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The strings also contained type 6 collagen and fibronectin , but very little , if any , of the basement membrane components laminin and heparin sulfate proteoglycan ( HSPG ) . ^^^ They contained other basement membrane associated components ( laminin , HSPG ) and fibronectin , but not type 6 collagen . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Basement membrane associated heparan sulfate proteoglycan ( HSPG ) and fibronectin were determined by enzyme immunoassay . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We used immunohistochemical techniques to visualize the spatial and temporal distribution of laminin , a heparan sulfate proteoglycan ( HSPG ) , fibronectin , and type 4 collagen on cultured chick myotubes during agrin induced aggregation of AChRs . ^^^ Myotubes displayed significant amounts of laminin and HSPG , lesser amounts of type 4 collagen , and little , if any , fibronectin . ^^^ Agrin treatment caused cell surface laminin and HSPG to patch , while collagen and fibronectin distributions were generally unaffected . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The nature of immune complexes and their relationship to the normal glomerular basement membrane ( GBM ) components type 4 collagen , fibronectin , and heparan sulphate proteoglycans ( HSPG ) have been examined in the glomeruli of 7 cases of systemic lupus erythematosus ( SLE ) glomerulonephritis using an ultrastructural immunogold technique . ^^^ The normal GBM components type 4 collagen , fibronectin , and HSPG were found within all the glomeruli , but did not have the same distribution . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| On the basis of these findings , a study was undertaken to observe cell shape and surface morphology by scanning electron microscopy and to define the immunocytochemical localization of 4 basal lamina components ( type 4 collagen , laminin , fibronectin , heparan sulfate proteoglycan ( HSPG ] . ^^^ The following results were noted for the dystrophic muscle cells : ( 1 ) the cell surface was smooth with a few slender cell processes and anchorage extensions ; ( 2 ) distribution of type 4 collagen and laminin was heterogenous , with large patches ( type 4 collagen ) or a reticulum ( laminin ) ; ( 3 ) in contrast , fibronectin and HSPG levels were clearly decreased . ^^^ Cell surface morphology may be related to the decreases in fibronectin and HSPG , which could reflect a more general decrease in basal lamina . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Human keratinocytes adhered best on FN and less well on types I / III collagen , type 4 collagen , and heparan sulfate proteoglycan ( HSPG ) as compared with bovine serum albumin ( BSA ) ( control ) or laminin ( La ) . ^^^ Cell growth assayed for 7 8 days on the dishes coated with various extracellular matrices revealed significantly increased keratinocyte growth on FN and on types I / III collagen in comparison with that on type 4 collagen , HSPG , BSA ( control ) , or La . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| While the enlarged mesangial matrix in diffuse glomerulosclerosis showed an increased staining reaction for the basement membrane components collagen 4 and 5 , laminin and fibronectin , the staining pattern of the basement membrane associated heparan sulfate proteoglycan ( HSPG ) was markedly reduced . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We investigated the distribution of extracellular matrix components such as fibronectin , laminin , type 3 , 4 , 5 , and 6 collagens and heparan sulfate proteoglycan ( HSPG ) in normal and diseased glomeruli using the indirect immunofluorescence method . ^^^ Fibronectin , laminin , type 4 collagen and HSPG were increased in the thickened GBM of MN and in the expanded mesangium of PGN . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Binding of HSPG core to the protein ( Mr = 38 , 000 ) was not altered by the presence of an excess of heparin , heparan sulfate , fibronectin , laminin , or collagen 4 but was reduced by unlabeled HSPG core . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| This study was undertaken to elucidate the distributions of laminin , fibronectin , type 1 , 3 , 4 , 5 and 6 collagen and heparan sulfate proteoglycan ( HSPG ) in diabetic nephropathy , using immunohistochemical procedures . ^^^ On the other hand , the components detected in the slightly expanded mesangial matrix were type 4 , 5 and 6 collagen , fibronectin and HSPG , but not laminin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have localized by immunocytochemistry at the LM and EM level , procollagen type 3 ( PIIIP ) , fibronectin ( FN ) and heparan sulfate proteoglycan ( HSPG ) . ^^^ In the latter location , the ultrastructural distribution of HSPG resembles that of FN , i . e . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Furthermore , while both cell lines possess similar amounts of cell surface HSPG with hydrophobic properties , that of RicR 14 cells had decreased sulfation , reduced affinity for fibronectin and decreased half life on the cell surface when compared to the normal counterpart . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The staining for type 4 collagen , fibronectin , and heparan sulfate proteoglycan HSPG ) was less intense than that for laminin , but was also localized in the BM along the basal side of the RPE . ^^^ Hence the presence of type 4 collagen , laminin , fibronectin , and HSPG in the BM of RPE in vivo during all the stages of development investigated supports the concept that these macromolecules are important basic components of this , and other , BMs . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Regional patterns of deposition of laminin ( LN ) , fibronectin ( FN ) , type 4 collagen ( 4 ) , and heparan sulfate proteoglycan ( HSPG ) were examined during the formation of the caudal neural tube in embryos homozygous for the delayed Splotch gene and in their normal littermates . ^^^ During posterior neuropore closure these components were normally restricted to forming basal laminae , with FN and HSPG additionally deposited in the mesenchyme . ^^^ Unlike control embryos in which medial regions of the neuroepithelial basal lamina contained greatest amounts of all four , the dorsolateral zone contained less LN and 4 and more FN and HSPG , in affected embryos these components were less densely deposited medially , reflecting perhaps the poor structural organization of the notochord . ^^^ In controls , with mesenchymal cell aggregation FN and HSPG were displaced from between cells to the forming basal lamina . ^^^ In delayed Splotch embryos , FN and HSPG were incompletely removed from aggregating cell surfaces , the normal morphogenetic cell shaping changes failed to occur and in many embryos a central lumen did not form ; the overgrown , aggregated cells merging with the abnormally splayed anterior neural folds . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The potential significance of this observation to developmental biology lies in the possibility that BM or their individual components ( i . e . , fibronectin ( FN ) , laminin ( LM ) , type 4 collagen , and heparin sulfate proteoglycan ( HSPG ] may function as the regulatory site of epithelial differentiation and morphogenesis . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Double immunofluorescent staining of fully adherent rat embryo fibroblast cells showed some co distribution of HSPG and FN , and this was confirmed by immunoelectron microscopy , which detected HSPG at localized areas of dorsal and ventral cell membranes , overlapping cell margins , and in the extracellular matrix . ^^^ During cell shape changes on rounding and spreading , HSPG and FN may not co distribute . ^^^ Double labeling for actin and either HSPG or FN showed a closer correlation of actin with HSPG than with FN . ^^^ The studies are consistent with HSPG being closely involved in a transmembrane cytoskeletal matrix interaction ; the possibility that HSPG coordinates the deposition of FN and other matrix components with cytoskeletal organization is discussed . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We also suggest that the cell matrix interactions documented for BPA , HSPG , laminin , and fibronectin may depend on the type of tissue involved and its state of development , differentiation , or repair . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| To examine whether the extracellular matrix ( ECM ) plays a role in mediating interactions between the apical ectodermal ridge ( AER ) and the subjacent mesoderm in the chick wing bud , we used immunohistochemistry to locate the following tissue components during wing morphogenesis : types 1 and 4 collagens , fibronectin , the basal lamina form of heparan sulphate proteoglycan ( HSPG ) , laminin , and the beta 1 integrin subunit . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : We studied the immunohistochemical expression of the ECM components collagen type 1 , 3 , and 4 , heparan sulfate proteoglycan ( HSPG ) , laminin , and fibronectin in cortical tissue of six HCHWA D patients , two AD patients , and five controls . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The matrix components studied ( laminin , plasma and cellular fibronectin , type 4 collagen , including the NC 1 , alpha 1 and alpha 3 chains , heparan sulphate proteoglycan ( HSPG ) core protein , thrombospondin ) were characteristically seen within the glomeruli . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical observation clarified the localization of heparan sulfate proteoglycan ( HSPG ) and fibronectin ( FN ) around osteoclast progenitor cells . ^^^ In conclusion , bone resorption at the metastatic sites of A 375 is mediated via osteoclasts and A 375 cells may be involved in the differentiation and activation of osteoclasts in association with stromal cells , extracellular matrices ( HSPG , FN ) and osteotropic cytokines ( IL 6 , PGE 2 , TGF alpha ) . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical staining was performed using antibodies against the major components of basement membranes such as laminin , heparan sulfate proteoglycan ( HSPG ) , collagen 4 and fibronectin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The endothelial matrix components , fibronectin and basement membrane associated heparan sulfate proteoglycan ( HSPG ) , were measured by enzyme immunoassay . ^^^ Treatment of proliferating endothelial cells with heparin ( 0 900 micrograms / ml ) induced a dose dependent decrease in endothelial HSPG content , whereas the fibronectin content was unaltered . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that ( 1 ) osteoblasts and osteoclast lineage cells synthesize HSPG ; ( 2 ) both membrane and matrix HSPG are localized in bone tissue ; and ( 3 ) HSPG may play an important role in cell cell interaction between fibroblast like cells and osteoclast lineage cells by reserving heparin binding growth factors and / or heparin binding adhesion molecules , such as fibronectin . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In the present study , the composition of the endothelial cell connecting filaments was investigated by indirect immunogold labeling with antibodies to the microfibril proteins , MP 340 ( fibrillin ) and MAGP , and to fibronectin and heparan sulfate proteoglycan ( HSPG ) . ^^^ Anti fibronectin strongly labeled the connecting filaments and a weak immunoreaction was seen with anti HSPG . ^^^ Little or no reaction was seen with anti fibronectin or anti HSPG . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We immunohistochemically analyzed the presence or absence of a pericellular basement membrane in benign and malignant soft tissue tumors of different origin of peripheral nerve , smooth and striated muscle , fat tissue , connective tissue , blood and lymph vessels , cartilage and bone to test the role of the expression of the BM components collagen 4 , laminin , heparan sulfate proteoglycan ( HSPG ) and fibronectin as a differential diagnostic aid . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The distribution of fibronectin ( FN ) , vitronectin ( VN ) , laminin ( LN ) , heparan sulfate proteoglycan ( HSPG ) , type 3 , 4 , 5 , 6 collagen , fibronectin receptor ( FNR ) and vitronectin receptor ( VNR ) in the glomerulus was studied employing the indirect immunoperoxidase method . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| One possible site of HSPG attachment is a heparin binding domain of fibronectin , which is present in the synthetic peptide FN C / H 2 . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Tissue sections were stained with an indirect immunoperoxidase technique using antibodies against collagen 1 , 3 , 4 , 5 , 6 , laminin , fibronectin , decorin and heparansulphate proteoglycan core protein ( HSPG ) . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We here investigated immunohistochemically the expression of other components of the extracellular matrix ( ECM ) , including collagen type 4 , heparan sulfate proteoglycan can ( HSPG ) , chondroitin 4 sulfate proteoglycan , decorin , and fibronectin in adhalin deficiency , compared with other types of muscular dystrophy . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We immunostained 60 angioproliferative lesions ( angiosarcoma , sclerosing hemangioma of skin , pyogenic granuloma , capillary hemangioma , lymphangioma , glomangioma and granulation tissue ) and 23 cases of Kaposi ' s sarcoma ( KS ) for the major macromolecular components laminin , collagen type 4 , fibronectin and heparan sulfate proteoglycan ( HSPG ) . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Muscle integrin clusters were usually associated with congruent basal lamina accumulations containing laminin and a heparan sulfate proteoglycan ( HSPG ) , sometimes including fibronectin and vitronectin acquired from the surrounding medium . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of hyperglycemia on mesangial proliferation and heparan sulfate proteoglycan ( HSPG ) and fibronectin production . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We examined the distribution of type 4 , 5 , and 6 collagens ( Cols ) , laminin ( LM ) , fibronectin ( FN ) , and heparan sulfate proteoglycan ( HSPG ) in the rat testicular lamina propria . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Diabetic vascular complications are characterized by structural alterations of extracellular matrix ( ECM ) components in glomeruli and large vessel walls , namely , accumulation of collagen 4 , collagen 6 and fibronectin and relative decrease of heparan sulphate proteoglycan ( HSPG ) . ^^^ TGF beta stimulates production of ECM components such as collagen 4 , fibronectin , proteoglycans ( decorin and biglycan ) without increasing HSPG . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| To test whether removal of HSPG exposes fibronectin , a candidate Lp ( a ) binding protein in the matrix , antifibronectin antibodies were used . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In this study , we analyzed 66 cases of laryngeal carcinomas using immunohistochemistry for the visualization of the major BM components collagen 4 and 7 , laminin 1 , heparan sulfate proteoglycan ( HSPG , perlecan ) and fibronectin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| HSPG may play an important role in cell cell interaction between osteoblasts and osteoclasts by reserving HBGF and heparin binding adhesion molecules such as fibronectin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We analyzed HSPG localization in primary corneal fibroblasts , cultured on fibronectin or collagen type 1 matrices , using confocal laser scanning microscopy and cell fractionation . ^^^ Image analysis revealed that the nuclear localization of HSPG core proteins was greater when cells were cultured on fibronectin versus collagen . ^^^ Furthermore , activation of protein kinase C with phorbol 12 myristate 13 acetate inhibited nuclear targeting of HSPG in cells on fibronectin , whereas inhibition of protein kinase C with Ro 31 8220 greatly enhanced nuclear localization of HSPG in cells on both collagen and fibronectin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recently , nuclear localization of HSPG was shown to increase in corneal stromal fibroblasts plated on fibronectin ( FN ) , an extracellular matrix protein whose appearance in the corneal stroma correlates with injury . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Here , we investigated the effects of HSPG disruption on the adhesion , migration , and mechanotransduction of ECs cultured on fibronectin . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Heparan sulfate proteoglycan ( HSPG ) and fibronectin were localized in the intercellular space between osteoblasts and osteoclasts . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Among the ECM biopolymers , heparan sulfate proteoglycan ( HSPG ) and fibronectin enhanced invasive growth , collagen type 4 reduced it , while laminin had no effect . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Participation of syndecan 2 in the induction of stress fiber formation in cooperation with integrin alpha5beta1 : structural characteristics of heparan sulfate chains with avidity to COOH terminal heparin binding domain of fibronectin . ^^^ The present study provides direct evidence that syndecan 2 participates selectively in the induction of stress fiber formation in cooperation with integrin alpha5beta1 through specific binding of its heparan sulfate side chains to the fibronectin substrate . ^^^ Our previous study with Lewis lung carcinoma derived P 29 cells demonstrated that the cell surface heparan sulfate proteoglycan , which binds to fibronectin , is syndecan 2 ( N . ^^^ We here report that in vitro treatment of the cells by antisense oligonucleotide for syndecan 2 resulted in a failure to form stress fibers on fibronectin substrate in association with specific suppression of its cell surface expression . ^^^ All these results consistently suggest that syndecan 2 proteoglycan interacts with the C terminal heparin binding domain of fibronectin at the highly sulfated cluster ( s ) , such as [ IdoA ( 2OS ) GlcNS ( 6OS ) ] ( 6 ) present in its heparan sulfate chains , to result in the induction of stress fiber formation in cooperation with integrin alpha5beta1 . . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We report here that syndecan 2 functions in the ectoderm to mediate cardiac and visceral situs , upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We document here the involvement of syndecan 2 acting alone or co operatively with integrin alpha5beta1 , for regulation of actin cytoskeletal organization on cell adhesion to fibronectin , using fibronectin recombinant polypeptides containing the ligands for either or both of these receptors as substrata . ^^^ This was confirmed by the finding that overexpression of syndecan 2 by transfection of its cDNA into LM 66 H11 cells caused the formation of stress fibres on the fibronectin substratum . ^^^ |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|