Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.70228867
Moreover , in all circumstances observed in this study , tenascin always co localized with fibronectin , suggesting fibronectin is indispensable for the function of tenascin . . 0.70228867^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.74055287
Anti TN 68 , an antibody that recognizes an epitope in the carboxyl terminal type 3 repeats involved in the interaction of TN with both FN and cells , blocked the inductive effect of the FN / TN substrate , whereas anti TNM 1 , an antibody that recognizes an epitope in the amino terminal anti adhesive region of epidermal growth factor like repeats , had no effect . 0.74055287^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Prior to shelf remodelling , this infrastructure may be anchored by a specialized region of the midoral epithelial mesenchymal interface and the subjacent mesenchyme which is characterized by the unique distribution of collagen 3 , fibronectin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Synthesis of undulin by rat liver fat storing cells : comparison with fibronectin and tenascin . ^^^ The aim of our study was to investigate the synthesis of undulin , a recently described connective tissue protein belonging to the fibronectin tenascin superfamily of glycoproteins , by fat storing cells in primary culture . ^^^ In contrast to fibronectin and tenascin , undulin was already synthesized by freshly isolated FSCs and during the early stage of primary FSC culture ( `` resting ' ' cells ) , supporting the hypothesis that undulin is associated with a differentiated mesenchyma . ^^^ However , in analogy to fibronectin and tenascin , undulin was also synthesized by `` activated ' ' FSCs , indicating that undulin might also be of importance in dedifferentiated tissues . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
BACKGROUND : Undulin is a novel large glycoprotein of the interstitial extracellular matrix belonging to the fibronectin tenascin glycoprotein gene family . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin distribution in human normal and pathological synovium . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Structure of a fibronectin type 3 domain from tenascin phased by MAD analysis of the selenomethionyl protein . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
So called `` fibrin cuffs ' ' were highly organized structures composed of laminin , fibronectin , tenascin , and collagen as well as trapped leukocytes and fibrin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cells producing fibronectin but not tenascin attached and spread on plastic culture dishes , while those producing tenascin alone remained suspended in the medium or were rarely attached . ^^^ Tenascin also inhibited fibronectin mediated adhesion of MCF 7 breast carcinoma cells in vitro . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We used immunocytochemistry to define the localization of tenascin and compare this with the localization of non collagenous proteins , such as laminin and fibronectin , in normal human liver and pathological liver from patients with chronic hepatitis , liver cirrhosis and hepatocellular carcinoma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
After injury , tenascin increased on the outer surface of regenerating myofibers , where cellular fibronectin also accumulated . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of major adhesive ECM molecules , constituting the endothelial basement membrane ( i . e . , fibronectin , laminin A , B and collagen 4 ) and of other attachment factors , such as SPARC ( osteonectin ) , tenascin and thrombospondin 1 , was examined . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We found that the MS 1 fraction also contained fibronectin and tenascin but not laminin or collagen IV . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Among matrix molecules , laminin and type 4 collagen displayed a pattern similar to that of the controls , whereas fibronectin and tenascin deposition were apparently increased . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cultures of ventral mesencephalon from rat embryos ( E 13 ) were plated on plastic dishes coated with the following substrates : L 1 , L2 / HNK 1 `` residual ' ' ( mainly J1 / 160 but also tenascin ) , MAG antigens from mouse brains , laminin , fibronectin , poly L lysine , RGD peptide , and plastic alone . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To understand cell interactions during induction of skin appendages , we studied the roles of adhesion molecules N CAM , tenascin , integrin , and fibronectin during feather development . ^^^ Perturbation of embryonic skin explant cultures with antibodies showed that anti integrin beta 1 and anti fibronectin blocked epithelial mesenchymal interaction , anti N CAM caused uneven segregation of mesenchymal condensation , and anti tenascin inhibited feather bud elongation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin promotes cerebellar granule cell migration and neurite outgrowth by different domains in the fibronectin type 3 repeats . ^^^ Localization of the immunoreactive domains by EM of rotary shadowed tenascin molecules revealed that the mAbs J1 / tn4 and J1 / tn5 , like the previously described J1 / tn1 antibody , bound between the third and fifth fibronectin type 3 homologous repeats and mAb J1 / tn3 bound between the third and fifth EGF like repeats . mAb J1 / tn2 had previously been found to react between fibronectin type 3 homologous repeats 10 and 11 of the mouse molecule ( Lochter , A . , L . ^^^ These observations indicate that tenascin influences neurite outgrowth and migration of cerebellar granule cells by different domains in the fibronectin type 3 homologous repeats . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cluster of fibronectin type 3 repeats found in the human major histocompatibility complex class 3 region shows the highest homology with the repeats in an extracellular matrix protein , tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In an optical and scanning electron microscope study of the processes of de novo trabecular generation , the immunohistochemical distribution of collagen Types 1 , 2 and 3 , together with the matrix organising proteins fibronectin and tenascin , has been examined in the ossifying human femoral anlage . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of tenascin did not strictly parallel that of fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and fibronectin in the rabbit cornea after excimer laser surgery . ^^^ After various intervals the animals were killed and the cornea excised and investigated immunohistochemically for the expression of extracellular matrix ( ECM ) proteins , fibronectin and tenascin . ^^^ Fibronectin was shown to occur earlier than tenascin , and the two also had different distribution patterns . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Distribution of the extracellular matrix proteins tenascin , fibronectin , and vitronectin in fetal , infant , and adult human spleens . ^^^ Using immunohistochemistry , we investigated the distribution of the extracellular matrix ( ECM ) glycoproteins tenascin , fibronectin , and vitronectin in fetal [ 16 24 gestational weeks ( GW ) ] , infant ( 40 GW ) , and adult human spleens to clarify the presence of these proteins during different phases of maturation . ^^^ In the red and white pulp , tenascin and fibronectin were constant components of the reticular fibers from the age of 18 GW onwards , whereas vitronectin was seen only in adult spleens . ^^^ The immunohistochemical staining patterns of tenascin and fibronectin remained unchanged at different fetal ages . ^^^ Ring fibers , which are modified basement membranes around venous sinuses , became visible relatively late , and in adult spleens they contained both tenascin and vitronectin but lacked fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Frozen tissue samples from biopsies of acute ( n = 14 ) and chronic ( n = 12 ) human renal allograft rejections were studied to compare distribution of tenascin , the extradomains A and B ( EDA , EDB ) , and oncofetal ( Onc ) isoforms of cellular fibronectin ( cFn ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of the cell adhesion proteins vitronectin , fibronectin , tenascin , and laminin as well as several integrin subunits , alpha 2 , alpha 5 , and alpha 5 , was studied in primate periodontal tissues . ^^^ Epithelial basement membranes stained positively for both fibronectin and tenascin . ^^^ The distribution of fibronectin , tenascin , and laminin is related to previous findings in other species . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin can promote neurite outgrowth in vitro and can inhibit cell interactions with fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Binding of immunopurified 125I labeled contactin / F11 to immobilized tenascin is completely inhibited by the addition of soluble tenascin or contactin / F11 , but not by fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Histopathologic study of conjunctival membranes from two cases of membranous conjunctivitis revealed polymorphonuclear leukocytes within a matrix composed of fibrin , tenascin and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Functionally different tenascin ( TN ) isoforms , containing varying numbers of a 91 amino acid motif resembling the fibronectin type 3 homology repeat , may be generated by alternative splicing of the TN primary transcript . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunoprecipitation of newly synthesized matrix proteins showed that , under serum free conditions , cultured vascular smooth muscle cells constitutively produced high levels of fibronectin , small amounts of laminin , and a barely detectable amount of tenascin . ^^^ Angiotensin 2 treatment increased synthesis of a 230 kDa tenascin glycoprotein by 9 fold and fibronectin synthesis by only 30 40 % during a 24 h treatment period , without stimulating laminin production or a general increase in the synthesis of secreted proteins . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In vitro and in vivo studies have shown that Ito cells are able to express the `` smooth muscle ' ' isoform of alpha actin which seems to characterize the activated stage of the cells . `` Activated ' ' Ito cells synthesize and secrete collagen and non collagen components of the extracellular matrix like fibronectin , laminin , tenascin and entactin . `` Quiscent ' ' Ito cells synthesize mostly collagen type 4 and 3 while `` activated ' ' Ito cells also synthesize alpha 2 macroglobulin , a potent protease inhibitor . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin was concentrated at the base of both villus and lower crypt cells while cellular fibronectin was mostly detected in association with the crypt cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This includes effects on the synthesis and secretion of thrombospondin , fibronectin , tenascin , etc . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
They are followed by a proline rich , repetitive segment C 3 of 122 residues , with similarity to some salivary proteins , and domain C 4 ( 89 residues ) , which is similar to the type 3 repeats present in fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition , a substratum coated with a mixture of fibronectin and tenascin was found to prevent mesodermal cell migration . ^^^ Our results show that exogenous tenascin can be incorporated into embryonic ECM and interferes in vivo with the interactions of cells with a fibronectin rich matrix . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Sections from the anterior segment of the fetal and adult human eye and from limbal tissue excised during standard trabeculectomies were studied immunohistochemically with monoclonal antibodies against human tenascin or monoclonal antibodies against cellular fibronectin ( cFN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
What distinguishes tenascin from fibronectin . ^^^ Tenascin and fibronectin are two major extracellular matrix glycoproteins . ^^^ Fibronectin is a dimer , whereas tenascin is a hexamer . ^^^ Often fibronectin and tenascin are colocalized in tissues , but the occurrence of tenascin is much more restricted when compared with fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The capsules of the tendon organs were positive for connective tissue macromolecules typical of basal lamina ( collagen type 4 , laminin , and heparin sulfate proteoglycan ) and for tenascin , collagen types 3 and 6 , and fibronectin . ^^^ Tongues of connective tissue containing tenascin , collagen types 1 and 6 , and fibronectin extended into the fissures . ^^^ Distally the tongues were continuous with the tenascin in the capsule and just internal to the capsule , fibronectin and basal lamina macromolecules in the capsule , and collagen type 1 in the collagenous bundles . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As compared to laminin , fibronectin and collagen type 4 , tenascin has the most restricted distribution . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Antibodies against tenascin / cytotacin , fibronectin , laminin , N CAM , thrombospondin , heparan sulfate proteoglycan , and the p 185 protein product of the neu oncogene were employed in indirect immunofluorescence experiments . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In Xenopus , we investigated the origin of enteric neurones and their distribution in relation to the extracellular matrix ( ECM ) components , fibronectin ( FN ) and tenascin ( TN ) . ^^^ The distribution of enteric neurones was studied in relation to fibronectin ( FN ) and tenascin ( TN ) , glycoproteins of the ECM , which support ( FN ) and inhibit ( TN ) amphibian NC cell migration . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A longer variant contains 13 fibronectin type 3 repeats , whereas a shorter splice variant of mouse tenascin lacks the 5 type 3 repeats that occur directly after the fifth repeat in the longer variant . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical localization of the matrix glycoproteins tenascin and the ED sequence containing form of cellular fibronectin in human permanent teeth and periodontal ligament . ^^^ The expression of two matrix glycoproteins , tenascin and cellular fibronectin ( cFN ) , has been studied in fully developed human permanent teeth , periodontal ligament , and alveolar bone , in both frozen and paraffin processed material . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Neural cell adhesion molecules , tenascin , and fibronectin are induced in the granulation tissue but the order of prevalence is fibronectin , tenascin , N CAM . ^^^ The order of appearance is N CAM and fibronectin , and then tenascin . ^^^ The order of disappearance is N CAM , tenascin , fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of type 1 and 2 collagens , fibronectin and the fibronectin integrin receptor , tenascin , laminin , link protein , and cartilage specific glycosaminoglycans was examined in the primate temporomandibular joint complex using an immunohistochemical approach . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The major matrix components were fibronectin and heparan sulfate proteoglycan ; however , laminin nidogen , tenascin , glia derived nexin ( GDN ) and chondroitin 4 sulfate proteoglycan were also found . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunolocalization of collagen types 1 and 3 , tenascin , and fibronectin in intramembranous bone . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In contrast to the neurite growth promoting effects of substrate bound J1 / tenascin , neurite outgrowth on polyornithine , laminin , fibronectin , or J1 / tenascin as substrates was inhibited by addition of soluble J1 / tenascin to the cultures . ^^^ The J1 / tn2 epitope localizes to a fibronectin type 3 homology domain that is presumably distinct from the putative Tn 68 cell binding domain of chicken tenascin for fibroblasts , as shown by electronmicroscopic localization of antibody binding sites . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have investigated mesenchymal properties in budding vs non budding regions of the early chick lung , including sources of mesenchyme , cell shapes and densities , morphology and composition of the basement membrane , and distribution of the ECM components collagen , fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical localization of tenascin and fibronectin in the dentine and gingiva of Canis familiaris . ^^^ In periodontium , anti tenascin immunoreactivity was stronger in the oral and sulcular gingival epithelia than in the underlying connective tissue , in contrast to the strong staining of connective tissue by anti fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and of the ED B containing oncofetal fibronectin isoform in human cancer . ^^^ Tenascin ( TN ) and the oncofetal ED B containing fibronectin isoform ( B FN ) have been reported to be stromal markers of a number of malignancies . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We studied by immunohistochemistry , the distribution of tenascin ( Ten ) , cellular fibronectin ( cFn ) , laminin and certain pertinent extracellular matrix protein receptors in normal human female breast , variants of fibrocystic disease ( FCD ) , benign tumors , and ductal and lobular carcinomas . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Molecular analysis of the tenascin gene revealed that it contains a region homologous to the fibrinogen gene , and repetitive sequences of the type 3 fibronectin and epidermal growth factor genes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Localization of heparan sulfate proteoglycan , type 4 collagen and laminin , three basement membrane components , as well as fibronectin and tenascin , were assessed by indirect immunofluorescence staining on cryostat sections , and correlated to morphogenesis and epithelial cell differentiation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin ; its distribution is believed to be temporarily and spatially limited . ^^^ The staining pattern obtained with a fibronectin specific antiserum is somewhat comparable with that of tenascin but the vessel wall was positive . hepatocytes , Kupffer cells , ITO cells and endothelial cells were isolated from rat liver and studied for their capacity to express the tenascin gene . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To determine if the deposition of tenascin in the neointima after arterial injury was related to changes in smooth muscle function , freshly isolated rat aortic smooth muscle cells were seeded on a substrate of plasma fibronectin and allowed to modulate from a contractile to a synthetic state in a serum free medium . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Qualitative and quantitative changes of human tenascin expression in transformed lung fibroblast and lung tumor tissues : comparison with fibronectin . ^^^ Qualitative and quantitative alterations of human tenascin ( TN ) expression in virally transformed lung fibroblasts and in lung tumor tissues were investigated using S 1 nuclease protection analysis in comparison with those of fibronectin ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Undulin is a novel member of the fibronectin tenascin family of extracellular matrix glycoproteins . ^^^ Chem . 265 , 8823 8832 ) , our finding of differentially spliced type 3 homology units , as found in tenascin and fibronectin , suggests that undulin is another member of the fibronectin tenascin family of extracellular matrix glycoproteins . ^^^ Furthermore , as in fibronectin and tenascin , undulin bears an additional subset of interactive domains tailored to specific structural and functional roles in development and differentiation . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and cellular fibronectin in the rabbit cornea after anterior keratectomy . ^^^ Anterior keratectomy ( AKE ) was done on rabbits , and the appearance of immunohistochemically demonstrable tenascin ( TN ) or cellular fibronectin ( cFN ) was studied at different times ( 5 min to 14 months ) after the operation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Because of the model character of this tumor for hormone associated cancer , it was further investigated in this study with respect to morphology , enzyme and intermediate filament pattern , the expression of alpha smooth muscle actin and the extracellular matrix proteins fibronectin and tenascin . ^^^ Mesothelia surrounding metastatic tumor complexes were positive for vimentin , desmin , alpha smooth muscle actin , fibronectin , cytokeratin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Furthermore , the synthesis of hyaluronan and the expression of immunostained fibronectin , laminin , and tenascin were reduced in cultures exposed to 5 mM PNP Xyl . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A deduced amino acid sequence of NvTN . 1 showed a modular structure unique to tenascin characterized by epidermal growth factor like and fibronectin type 3 repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The spatial and temporal distribution of two components of the ECM , fibronectin and tenascin , were studied by immunostaining of cryosections from trunk wounds of fetal and adult sheep . ^^^ The distribution of fibronectin was similar in fetal and adult wounds but tenascin was present earlier in the fetal wound . ^^^ The attachment of fibroblasts to fibronectin is inhibited by tenascin and during development the appearance of tenascin in the ECM of migratory pathways correlates with the initiation of cell migration . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical demonstration of cellular fibronectin and tenascin in human epiretinal membranes . ^^^ The occurrence of fibronectin , cellular fibronectin and tenascin was studied immunohistochemically in epiretinal membranes from 5 patients with retinal detachment and 3 patients with macular pucker , and in preretinal membranes from 3 patients with proliferative diabetic retinopathy . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Three forms of tenascin clones were observed which varied with the number ( 8 10 ) of fibronectin type 3 ( FN 3 ) domains . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Electron microscopy using peroxidase antiperoxidase reveals that tenascin is present in nonstriated , 10 nm wide fibrils and in interstitial bodies , both of which have previously been reported to contain fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin variants : differential binding to fibronectin and distinct distribution in cell cultures and tissues . ^^^ In the chicken , three tenascin variants have been characterized that are generated by alternative splicing of 3 of its 11 fibronectin type 3 repeats . ^^^ Using monoclonal antibodies that react with common regions versus extra repeats of tenascin , we could distinguish and separate tenascin variants and investigate their interaction with fibronectin using multiple experimental procedures . ^^^ Interestingly , in all assays used the smallest tenascin variant bound more strongly to fibronectin than the larger ones . ^^^ These biochemical data were paralleled by the observation that in chick embryo fibroblast cultures only the smallest form of tenascin could be detected in the fibronectin rich extracellular matrix network laid down by the cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We find that integrins , fibronectin , laminin , and tenascin all play some role in cranial neural crest emigration . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The examined molecules include fibronectin , type 3 collagen , and tenascin , which all represent components of the mesenchymal ECM , the cell surface proteoglycan , syndecan , which functions as a receptor for interstitial matrix , and the cell surface receptor for epidermal growth factor . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As a step in defining the molecular environment for development of the mammalian cerebral cortex , we have used immunohistochemistry to analyze the distribution and remodeling of three major extracellular matrix ( ECM ) components , fibronectin , chondroitin sulfate proteoglycan ( CSPG ) , and tenascin , during embryonic and early postnatal stages in the mouse . ^^^ Labeling of fibronectin and CSPG declines rapidly as the cortical plate begins to differentiate into cortex ; labeling for tenascin first appears at this stage in the most mature layers , the marginal zone and subplate , then gradually becomes widespread throughout all of cortex and subcortical white matter . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The interaction of cells with this glial derived matrix requires divalent cations and is not mediated by several known RGD containing extracellular proteins , including fibronectin , vitronectin , thrombospondin , type 1 and type 4 collagen , and tenascin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The induction of tenascin was compared with fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Such embryos have defects in FN synthesis and gastrulation . ( b ) Fab ' fragments of anti FN and anti integrin VLA 5 IgGs prohibit mesodermal cell adhesion both in vitro and in vivo and gastrulation is arrested . ( c ) Peptides containing the RGDS sequence specifically inhibit interactions between migrating mesodermal cells and the FN fibrillar matrix . ( d ) Tenascin blocks cell adhesion to FN in vitro and gastrulation in vivo . ( e ) Antibodies against the cytoplasmic domain of beta 1 integrin , when injected into blastomeres , prevent FN fibrillogenesis in progeny of injected blastomeres and delay mesodermal cell migration selectively in the progeny of injected blastomeres but not in the uninjected blastomere progeny . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By use of specific antibody preparations we identified at least four species of glycopeptide present in stromal matrices ( namely , fibronectin , laminin , tenascin , and thrombospondin ) as well as three types of collagen ( types 1 , 3 , and 4 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As reported for the molecule described as a `` hexabrachion , ' ' tenascin contaminates so called `` cell surface fibronectin , ' ' where it accounts for most of the detectable hemagglutinating activity . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin interferes with fibronectin action . ^^^ The proportion between tenascin and fibronectin in mixtures used to coat the substrate determines the shape of the cells . ^^^ Tenascin inhibits integrin mediated chick fibroblast attachment to fibronectin , laminin , and the GRGDS peptide . ^^^ Rat fibroblast attachment to fibronectin , but not to laminin , is inhibited by tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of the extracellular matrix ( ECM ) glycoprotein , tenascin , has been compared with that of fibronectin in neural crest migration pathways of Xenopus laevis , quail and rat embryos . ^^^ In all species studied , the distribution of tenascin , examined by immunohistochemistry , was more closely correlated with pathways of migration than that of fibronectin , which is known to be important for neural crest migration . ^^^ We propose that tenascin is an important factor controlling neural crest morphogenesis , perhaps by modifying the interaction of neural crest cells with fibronectin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
One of the subunits of this putative tenascin receptor comigrates with the beta subunit of the fibronectin receptor in SDS PAGE and cross reacts with antibodies prepared against the fibronectin receptor in immunoblotting . ^^^ These results identify the tenascin receptor as a member of the fibronectin receptor family within the integrin superfamily of receptors . ^^^ The cell attachment response on tenascin is distinctly different from that seen on fibronectin , suggesting that cell adhesion and motility may be modulated at those sites where tenascin is expressed in the extracellular matrix . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibroblasts that proliferate near denervated synaptic sites in skeletal muscle synthesize the adhesive molecules tenascin ( J 1 ) , N CAM , fibronectin , and a heparan sulfate proteoglycan . ^^^ Four adhesive molecules , tenascin ( J 1 ) , N CAM , fibronectin , and a heparan sulfate proteoglycan , accumulate in interstitial spaces near synaptic sites after denervation of rat skeletal muscle ( Sanes , J . ^^^ Using immunofluorescence and immunoprecipitation methods , we found that fibroblasts isolated from perisynaptic regions of denervated muscle synthesize N CAM , tenascin ( J 1 ) , fibronectin , and a heparan sulfate proteoglycan in vitro . ^^^ To elucidate factors that might regulate the accumulation of these molecules in vivo , we analyzed the expression of tenascin ( J 1 ) and fibronectin by cultured fibroblasts . ^^^ Fibroblasts from synapse free regions of denervated muscle , as well as skin , lung , and 3T3 fibroblasts accumulate high levels of tenascin ( J 1 ) and fibronectin in culture , showing that perisynaptic fibroblasts are not unique in this regard . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of tenascin was spatially and temporally different from that of fibronectin , and tenascin appeared before laminin beneath migrating epidermis . ^^^ In cultured skin explants , in which epidermis migrated over the cut edge of the dermis , tenascin , but not fibronectin , appeared in the dermis underlying the migrating epithelium . ^^^ The results presented here suggest that tenascin is important in wound healing and is subject to quite different regulatory mechanisms than is fibronectin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have investigated the morphology and migratory behavior of quail neural crest cells on isolated embryonic basal laminae or substrata coated with fibronectin or tenascin . ^^^ On tenascin coated substrata , the rate of neural crest cell migration from neural tube explants was significantly greater than on uncoated tissue culture plastic , on fibronectin coated plastic , or on basal lamina isolated from embryonic chick retinae . ^^^ Neural crest cells on tenascin were rounded and lacked lamellipodia , in contrast to the flattened cells seen on basal lamina and fibronectin coated plastic . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Other ECM molecules , laminin , type 3 collagen , and fibronectin , did not show a staining pattern similar to that of syndecan and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of fibronectin and tenascin along migratory pathways of the neural crest in the trunk of amphibian embryos . ^^^ We have also used immunohistochemistry to study the distribution of the extracellular matrix ( ECM ) glycoproteins fibronectin ( FN ) and tenascin ( TN ) , which have been implicated in directing neural crest cells during their migrations in avian and mammalian embryos , in the neural crest migratory pathways of Xenopus and the axolotl . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The architecture of the ECM was revealed by silver and lectin staining ( peanut and Ricinus communis agglutinins , PNA and RCA 1 ) , by immunocytochemistry ( for fibronectin , tenascin , collagen type 1 ) and by ultrastructural analysis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cell adhesion to fibronectin and tenascin : quantitative measurements of initial binding and subsequent strengthening response . ^^^ Cell substratum adhesion strengths have been quantified using fibroblasts and glioma cells binding to two extracellular matrix proteins , fibronectin and tenascin . ^^^ When a mixed substratum of fibronectin and tenascin was tested , the presence of tenascin was found to reduce the level of the strengthening of cell adhesion normally observed at 37 degrees C on a substratum of fibronectin alone . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This review article summarizes our findings on the distribution patterns during tooth development of the ECM glycoproteins , fibronectin and tenascin , and of the cell surface proteoglycan , syndecan , which functions as a receptor for interstitial matrix . ^^^ Fibronectin and tenascin are enriched in the dental basement membrane at the time of odontoblast differentiation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin inhibited monocyte adhesion to fibronectin and enhanced the LFA 1 ( lymphocyte function associated antigen 1 ) dependent clustering of Epstein Barr virus transformed B cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Apparently enhanced staining was seen in tumours showing retraction artefact , which may be related to the observation that tenascin interferes with the cell binding function of fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Sedimentation in a cesium chloride gradient gave a higher buoyant density for human tenascin than for fibronectin , suggesting that it has a higher degree of glycosylation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Whereas fibronectin is expressed rather uniformly in matrices of embryonic mesenchyme , tenascin is found in the mesenchyme at sites of epithelial mesenchymal interactions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical localization of various matrix molecules showed that the matrix glycoproteins fibronectin and tenascin are accumulated in the dental basement membrane at the time of odontoblast differentiation . ^^^ Fibronectin and tenascin are known to interact with each other , with other matrix molecules as well as with the cell surface , and also to influence cell shape . ^^^ We suggest that fibronectin and tenascin are involved in the cell matrix interaction which leads to the polarization and differentiation of odontoblasts . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Neither fibronectin nor tenascin were concentrated at the myotendinous junction , but instead were present in a fibrillar staining pattern throughout the connective tissue which was closely associated with the myotendinous junction . ^^^ This interaction does not appear to involve extensive binding to fibronectin or tenascin , but may involve laminin and heparan sulfate proteoglycan . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Utilizing immunohistochemical techniques , positive detection of ECM proteins within the ( pre ) odontoblast or in their extracellular matrices has been demonstrated for ( pro ) collagen type 1 , 3 , 4 , 5 and 6 , fibronectin , tenascin , laminin , basement membrane heparan sulfate , nidogen , dentinophosphophoryns ( DPP ) , osteocalcin ( OC ) , osteonectin , osteopontin and 95 kDal glycoprotein . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition a morphometric study of extracellular matrix ( EM ) proteins cellular fibronectin and tenascin showed a 9 . 56 + / 1 . 9 fold and 3 . 35 + / 0 . 6 fold increase respectively in these proteins , as compared to normal kidney ( P < 0 . 001 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The extracellular matrix ( ECM ) proteins collagen 1 , 3 and 4 , laminin , fibronectin , vitronectin , thrombospondin , tenascin and their integrin receptors of the beta 1 and beta 3 subfamilies showed characteristic patterns of distribution in different compartments of non reactive and reactive lymph nodes ( human and monkey ) . ^^^ Thus , ECM proteins ( collagens , laminin , fibronectin and tenascin ) were abundant in the interfollicular ( T cell rich ) compartments of non reactive as well as reactive lymph nodes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Molecular analysis of the tenascin gene revealed that it contains a region homologous to epidermal growth factor genes , repetitive sequences of the type 3 fibronectin and the fibrinogen gene . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have found that endothelial cells adhere much more strongly than fibroblasts to domains of tenascin and fibronectin . ^^^ When coated for short times ( 1 2 hours ) on plastic , tenascin had no adhesion activity , in contrast to fibronectin and the expression proteins , which gave strong adhesion under these conditions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Here we found that the neurite promoting activity of tenascin for sensory neurons is developmentally regulated : very young sensory ganglia of stage 23 ( 4 days old ) embryos grew neurites on tenascin as fast as on laminin and fibronectin . ^^^ The growth response of older ( day 7 and 9 ) ganglia on laminin and fibronectin was similar to that of 4 day old ganglia , while on tenascin neurite growth occurred only after a lag phase and at a slower rate . ^^^ While tenascin promotes neurite outgrowth of peripheral neurons , we found that it does not allow satellite cell migration when it is present on the substratum , and it inhibits migration of satellite cells on fibronectin when added in soluble form . ^^^ In contrast , soluble tenascin did not significantly alter the rate of neurite growth on tenascin , fibronectin or laminin substrata , although neurites were straighter and less attached . ^^^ Using patterned substrata of tenascin versus fibronectin or laminin confirmed that tenascin borders allow neurites to pass but act as barriers to migrating satellite cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Isoforms of cellular fibronectin and tenascin in amniotic fluid . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Ang 2 and ET 1 promote the synthesis and secretion of the glycoproteins thrombospondin , fibronectin , and tenascin . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We studied frozen sections of nine naevocellular naevi ( junctional , compound and intradermal ) , 40 dysplastic naevi , six pagetoid in situ melanomas and 12 superficial spreading melanomas in order to determine the expression of : the basement membrane proteins collagen type 4 and laminin , the interstitial collagen types 1 , 3 and 6 , and fibronectin and tenascin . ^^^ In the various stages of melanocytic tumour progression we observed : 1 loss of type 4 collagen and laminin within dermal melanocytic cell nests ; 2 de novo expression of basement membrane type 4 collagen and increased expression of the interstitial collagen types 1 , 3 and 6 , as well as tenascin and fibronectin in the dermal stroma surrounding dysplastic naevus cells and melanoma cells ; 3 presence of extracellular matrix components in close association with intra epidermally located invading atypical melanocytes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Mouse Lewis lung carcinoma derived cloned cell lines with different metastatic potentials ( P 29 , LM 12 3 , and LM 60 D6 cells with low , medium , and high metastatic potentials , respectively ) were subcutaneously injected , and the resultant tumor tissue was analyzed immunohistochemically for the localization of type 1 collagen , fibronectin , and tenascin , and biochemically for the levels of glycosaminoglycans . ^^^ RESULTS : In the subcutaneous low metastatic P 29 tumor , fibrillar extracellular matrices and fibroblast like cells surrounding tumor cells were stained strongly for type 1 collagen , fibronectin , and tenascin , but only weakly stained in the more highly metastatic LM 12 3 and LM 60 D6 tumors . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Purified tenascin and a recombinant tenascin fragment consisting of alternatively spliced fibronectin type 3 repeats , interfered with maintenance of uterine epithelial cell adhesion to Matrigel . ^^^ In contrast , other recombinant tenascin fragments or fibronectin had no effect in this regard . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A solid phase radioligand binding assay confirmed that neurocan , phosphacan , and phosphacan KS bind to tenascin but not to laminin and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The subunit molecular size of TN 10 is approximately 500 kD , suggesting that the protein may contain up to 40 fibronectin type 3 repeats , making it the largest tenascin family member known yet . ^^^ TN 10 in conditioned medium , as well as the purified protein bind to heparin , but no binding to tenascin C ( TN C ) , fibronectin , laminin or collagens could be detected . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It enables the assignment of corresponding repeats from different species and shows that for human tenascin several more alternatively spliced fibronectin type 3 repeats have been described than for chicken or mouse tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The difference is most likely due to alternative splicing which is known to occur in tenascin mRNA within the region of the fibronectin type 3 repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The immunohistochemical localization of heparan sulphate , collagen type 1 , 3 and 4 , laminin , tenascin , plasma and cellular fibronectin was studied in tooth germs from human fetuses . ^^^ In early pre dentin , collagen type 1 , laminin , tenascin and fibronectin were present . ^^^ Collagen type 1 and 3 , tenascin and fibronectin were localized to the mesenchymal intercellular matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type 3 domains from the extracellular matrix proteins tenascin and fibronectin . beta bulges and left handed polyproline 2 helices disrupt the regular beta sheet structure of both neuroglian domains . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These forms are the result of alternative splicing , which generates tenascin variants with different numbers of fibronectin type 3 repeats . ^^^ Genomic clones contained a sequence encoding a fibronectin type 3 repeat that corresponds to repeat ' C ' from the variable domain of human tenascin . ^^^ Finally , we provide evidence that additional fibronectin type 3 repeats , one corresponding to a recently discovered human repeat as well as one entirely novel sequence , also exists in chicken tenascin mRNA . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of extracellular matrices ( ECMs ) laminin ( LN ) , type 4 collagen ( 4 C ) , heparan sulphate proteoglycan ( HS PG ) , fibronectin ( FN ) , tenascin ( TN ) , decorin and vitronectin ( VN ) was examined immunohistochemically in 112 primary tumours and 29 metastatic cervical lymph nodes in oral squamous cell carcinoma ( OSCC ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Therefore , we have analysed the immunohistochemical distribution of type 1 , 3 , and 4 collagen , fibronectin , laminin and tenascin in four cases of synovial sarcoma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The presence of TGF beta 1 and TGF beta 2 in invasive breast carcinomas has been determined and related to pathological features , the presence of fibronectin and tenascin and lymphocyte / macrophage infiltration , using immunohistochemistry . ^^^ Prominent reactivity for TGF beta 1 was associated with lymph node metastasis , ( 0 . 02 > P > 0 . 01 ) , increased detection of cellular fibronectin , fine stromal fibronectin staining , more prominent reactivity for tenascin ( 0 . 02 > P > 0 . 01 ) , the presence of tumour associated macrophage infiltration and altered ratios of CD 4 and CD 8 lymphocyte populations , with CD 8 lymphocytes predominating . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Investigation of the expression of the extracellular matrix glycoproteins tenascin and fibronectin during acne vulgaris . ^^^ Tenascin and fibronectin are extracellular matrix glycoproteins which can interact with cells and alter their capacity to adhere , migrate and proliferate . ^^^ In contrast with fibronectin , tenascin has a restricted distribution in normal skin , but is induced during epidermal proliferation , and in wound healing . ^^^ Because acne involves hyperproliferation of ductal keratinocytes , and rupture of the duct may occur during inflammation , the distribution of tenascin and fibronectin was investigated in acne lesions , and also in acne keloids . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin and tenascin in rat tracheal wound healing and their relation to cell proliferation . ^^^ To investigate the relationship between cell proliferation and distribution of fibronectin and tenascin during wound healing , light and electron microscopy and immunohistochemistry for fibronectin , tenascin , and 5 bromodeoxyuridine ( BrdU ) were performed following mechanical injury of rat trachea . ^^^ Distribution of tenascin was restricted to granulation tissue in curetted areas which were covered with regenerating epithelium , while fibronectin stained diffusely in both curetted and non curetted areas . ^^^ Analysis of the relative intensity of fibronectin and tenascin staining showed that decreases of fibronectin staining were followed by increasing tenascin staining . ^^^ It is proposed that fibronectin and tenascin may contribute differently to tissue repair in the trachea by interfering with cell proliferation of epithelial cells and fibroblasts . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As we have shown before for tenascin , laminin and fibronectin , polarization was preceded by an increase in the number and length of all neurites during the first hours after cell plating . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunolabeling for NC , angioblasts and the extracellular matrix ( ECM ) glycoproteins fibronectin ( FN ) , laminin ( LN ) and tenascin ( TN ) revealed several instances where spatiotemporal patterns of NC migration coincide with the embryonic vascular pattern and its associated ECM . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical demonstration of tenascin and fibronectin in odontogenic tumours and human fetal tooth germs . ^^^ The distribution of tenascin and fibronectin ( plasma fibronectin ) was studied immunohistochemically in ameloblastomas , ameloblastic fibromas and ameloblastic carcinomas , as well as in tooth germs using monoclonal antibodies . ^^^ The results suggest that tenascin and fibronectin are involved in epithelial mesenchymal interactions of the tooth germ and in odontogenic tumours . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The integrin alpha 9 beta 1 mediates cell attachment to a non RGD site in the third fibronectin type 3 repeat of tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Appearance of the myofibroblastic phenotype in Dupuytren ' s disease is associated with a fibronectin , laminin , collagen type 4 and tenascin extracellular matrix . ^^^ This discrepancy between electron microscopic features and immunohistochemical findings prompted us to examine the composition of extracellular matrix ( fibronectin , laminin , collagen type 4 and tenascin ) in relation to the myofibroblast phenotype in proliferative nodules from 13 native surgical specimens of nodular palmar fibromatosis ( Dupuytren ' s disease ) . ^^^ The immunohistochemical staining for fibronectin was positive within the whole palmar aponeurosis and was particularly intense in the proliferative areas , whereas laminin , collagen type 4 and tenascin labelling was restricted to the alpha smooth muscle actin positive proliferative nodules . ^^^ The results substantiate an extracellular matrix formation by myofibroblasts with fibronectin , laminin , collagen type 4 and tenascin as constituents . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distributions of interstitial cells , fibronectin , and tenascin were determined in muscles inactivated by presynaptic blockade of muscle activity with tetrodotoxin . ^^^ We found that blockade of muscle activity for up to 4 wk produced neither the junctional accumulation of interstitial cells nor the junctional concentrations of tenascin and fibronectin normally present in denervated frog muscle . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To understand the alteration of extracellular matrix composition evoked by chemotactic factors , we have studied the expression of adhesive ( fibronectin ) and anti adhesive ( tenascin ) proteins in response to platelet derived growth factor BB ( PDGF BB ) , a potent chemoattractant for rat aortic smooth muscle cells ( ASMC ) . ^^^ PDGF BB markedly induced two major tenascin mRNA transcripts , whereas fibronectin mRNA levels did not change . ^^^ Functional studies showed that the unspliced isoform of human tenascin inhibited attachment of both human and rat ASMC to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The extracellular matrix components , tenascin and fibronectin , in Hirschsprung ' s disease : an immunohistochemical study . ^^^ Previous in vitro studies have suggested that successful neural crest cell migration in the developing gut could be influenced by the composition of the extracellular matrix components , tenascin and fibronectin . ^^^ The authors aimed to gain insight into the pathogenesis of Hirschsprung ' s disease ( HD ) by studying the distribution of tenascin and fibronectin in bowel specimens of patients with HD . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The extracellular matrix glycoprotein janusin , closely related to tenascin in its repeated motifs of epidermal growth factor , fibronectin type 3 , and fibrinogen like domains , displays in vitro a broad spectrum of functional diversity . ^^^ Like tenascin , it can modify the adhesive substrate properties of another extracellular matrix glycoprotein , fibronectin , whereby the smaller , 160 kD component of janusin exerts its effects by interaction with fibronectin and the 180 kD janusin component functionally modifies the fibronectin receptor via a disialoganglioside receptor . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The binding site is within the fibronectin type 3 homology region at the boundary of the alternatively spliced region of tenascin , requiring that fibronectin type 3 homology domains 5 and 9 be adjacent , as they are in the 190 kD tenascin isoform . ^^^ By means of fusion proteins , we have identified a potential binding site on the fifth fibronectin type 3 homology domain of tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Artificial substrate borders between tenascin and fibronectin or laminin act as selective barriers that allow neurites to pass while holding up satellite cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical studies to localise collagen 4 , laminin , fibronectin and tenascin were undertaken in 59 bladder biopsies . ^^^ Fibronectin and tenascin were found in the sub urothelial lamina propria and in some urothelial basement membranes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The structure and composition of human placental fibrinoid were studied on cryostat and paraffin sections and by transmission electron microscopy as well as immunohistochemistry using antibodies directed against fibrin , fibronectin isoforms , collagens 4 and 6 , laminin and tenascin . ^^^ In contrast , matrix type fibrinoid showed virtually no evidence of fibrin ; it was immunopositive for extracellular matrix molecules such as the fibronectins , particularly oncofetal fibronectin ( containing the ED B sequence ) , collagen 4 , laminin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical examination of neural cell adhesion molecule ( NCAM ) , tenascin and fibronectin on the development of cartilaginous tissue in canine mammary mixed tumors . ^^^ The expression of neural cell adhesion molecule ( NCAM ) , tenascin and fibronectin during cartilage like tissue formation in canine mammary mixed tumor was immunohistochemically examined . ^^^ NCAM , tenascin and fibronectin , therefore , may play crucial roles on the proliferation of myoepithelial cells and the subsequent development of cartilaginous tissue in canine mammary mixed tumor . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We performed an immunohistochemical study of type 4 collagen , laminin , fibronectin , and tenascin distribution in a series of 10 mixed tumors of the skin . ^^^ Laminin localized at the basement membrane around solid epithelial nests and tubulo alveolar structures , whereas type 4 collagen , fibronectin , and tenascin were also expressed in the myxoid stroma . ^^^ Tenascin and fibronectin localized in the chondroid matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Collagen type 1 , 6 , procollagen type 3 , undulin , tenascin and fibronectin were demonstrated in biopsy material of 4 cases by polyclonal antibodies . ^^^ In contrast to the surrounding connective tissue , label for collagen type 6 was weak , as was the reaction for fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Distribution of integrins alpha 5 beta 6 and alpha 9 beta 1 and their known ligands , fibronectin and tenascin , in human airways . ^^^ The extracellular matrix protein tenascin is a ligand for both of these receptors , and fibronectin is also a ligand for alpha 5 beta 6 . ^^^ In the present study , we used immunohistochemistry to examine the expression and spatial distribution of the alpha 9 subunit , alpha 5 beta 6 , tenascin , and fibronectin in the proximal airways of 10 normal nonsmoking subjects and eight patients undergoing lung resection for cancer . ^^^ Although both tenascin and fibronectin were present below the proximal airway epithelium of both normal nonsmoking subjects and smokers , the spatial patterns of integrin and ligand expression were not congruent , because the integrins were present diffusely on the cell surface and on some cells that were not in contact with the basement membrane , whereas the ligands were present principally in the subepithelial layer . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To investigate the adhesion of SC to extracellular matrix proteins , we examined the attachment of SC from normal and inflamed synovia to fibronectin , tenascin , laminin and collagen type 4 . ^^^ Compared to normal SC and SC of osteoarthritis , SC of rheumatoid arthritis showed an increased binding to tenascin , laminin , fibronectin and collagen type 4 , suggesting a distinctive interaction of SC and extracellular matrix proteins in rheumatoid arthritis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cellular fibronectin and tenascin in experimental perforating scleral wounds with incarceration of the vitreous . ^^^ The extracellular matrix glycoproteins fibronectin ( FN ) and tenascin ( TN ) have been located in epiretinal scar membranes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C binds heparin by its fibronectin type 3 domain five . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of cellular fibronectin and tenascin in the rabbit cornea after excimer laser photorefractive keratectomy : a 12 month study . ^^^ An indirect immunohistochemical technique was used to monitor the expression of cellular fibronectin ( cFN ) and tenascin ( TN ) in the rabbit cornea after photorefractive keratectomy ( PRK ) in a 1 year follow up study . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Finally , we mapped the active regions within the fibronectin type 3 repeat region of the tenascin molecule that are capable of inhibiting beta casein protein synthesis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Modulation of fibronectin and tenascin production in human bronchial epithelial cells by inflammatory cytokines in vitro . ^^^ Fibronectin ( Fn ) and tenascin ( Tn ) are two major extracellular matrix glycoproteins participating in tissue morphogenesis and repair . ^^^ Fibronectin ( Fn ) and tenascin ( Tn ) are two major extracellular matrix glycoproteins participating in tissue morphogenesis and repair . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and oncofetal fibronectin oncofetal markers or indicators of extracellular matrix remodelling . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Both fibronectin and tenascin were substantially decreased in chronically inflamed connective tissue , showing only punctate staining at the basement membrane zone . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type 3 repeats 6 8 . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Furthermore , mainly during diabetic pregnancies , extracellular matrix molecules such as tenascin and fibronectin also quantitatively increase at the vein wall level . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and fibronectin isoforms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It has been found that fibronectin ( FN ) , tenascin ( TN ) and to a lesser degree collagen 4 were abundant in the immediate vicinity of the tumor , but only TN penetrated tumor mass . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In our patient , immunohistochemical studies of involved and uninvolved skin showed an increase in fibronectin and tenascin deposition . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical evaluation of tenascin in benign eccrine gland tumors : comparison with laminin and fibronectin . ^^^ Surgically resected specimens of skin appendage tumors , spiradenoma , poroma of eccrine glands , syringoadenoma , syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin , as well as the basement membrane associated protein laminin , and the extracellular matrix protein fibronectin , using immunohistochemical methods . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Morphogenetic extracellular glycoproteins like fibronectin and tenascin seem over expressed in twin pregnancies . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Transforming growth factor beta regulates the expression of fibronectin and tenascin in BEAS 2B human bronchial epithelial cells . ^^^ We used monoclonal antibodies to study expression and extracellular matrix ( ECM ) incorporation of tenascin ( Tn ) and isoforms of fibronectin ( Fn ) in BEAS 2B immortalized human bronchial epithelial cells and the regulation of their synthesis by transforming growth factor ( TGF ) beta 1 and beta 2 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
No clear correlation was found between the axon growth promoting properties of these astrocyte cell lines with : ( 1 ) the expression of known neurite outgrowth promoting molecules such as laminin , fibronectin and N cadherin ; ( 2 ) the expression of known inhibitory molecules such tenascin and chondroitin sulphate proteoglycan ; ( 3 ) plasminogen activator and plasminogen activator inhibitor activity ; and ( 4 ) growth cone collapsing activity . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin isoforms in human renal cell carcinomas , renal cell carcinoma cell lines and xenografts in nude mice . ^^^ We studied the expression of tenascin ( Tn ) and isoforms of fibronectin ( Fn ) in human renal cell carcinomas ( RCC ) and oncocytomas , in RCC cell lines and in their s . c . implanted xenografts in nude mice . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This integrin is expressed in bronchiolar and alveolar epithelium during development and in settings of injury and / or inflammation and mediates attachment of epithelial cells to fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We generated a three dimensional model of fibronectin type 3 13 based on the structure of a homologous domain from tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin expression and fibronectin levels were elevated and laminin levels were decreased . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In fact , BMZ components displayed their normal pattern were this was preserved , and so were fibronectin and tenascin in the stroma underlying the tumor . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Therefore , the effects of TGF beta 1 on the cellular morphology and the distribution of ECM components such as laminin , tenascin , fibronectin , and types 1 and 4 collagens were investigated in confluent cultures of differentiated PECs during a period of 6 days . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
There was a progressive rise in the number of cortical interstitial fields with increased staining for collagen ( col ) 1 ( 18 , 29 , 44 % ) , col 3 ( 39 , 61 , 63 % ) , col 4 ( 7 , 13 , 29 % ) , laminin ( 4 , 10 , 30 % ) , fibronectin ( 14 , 28 , 37 % ) , tenascin ( 19 , 22 , 14 % ) and in total renal col measured biochemically ( 1 . 1 , 1 . 4 , 2 . 0x ) at weeks 1 , 2 and 3 , respectively . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The appearance of extracellular matrix ( ECM ) components which may regulate the developmental processes in the human embryonic axial mesenchyme and the notochord was studied in 5 human embryos between Carnegie stages 12 and 14 ( 4th and early 5th gestational wk ) by using Alcian blue histochemistry and immunohistochemistry with antibodies against types 1 and 2 collagens , the proteoglycans aggrecan , biglycan and decorin , the glycoproteins fibronectin , laminin and tenascin and the growth factor TGF beta . ^^^ The results demonstrate that the notochordal sheath contains high amounts of sulphated glycosaminoglycans , hyaluronic acid and the glycoproteins fibronectin , laminin and tenascin during all developmental stages examined . ^^^ The ECM of the axial mesenchyme is rich in sulphated glycosaminoglycans , hyaluronic acid , fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Distribution of undulin , tenascin , and fibronectin in the human periodontal ligament and cementum : comparative immunoelectron microscopy with ultra thin cryosections . ^^^ We studied the ultrastructural localization of three distantly related glycoproteins of the extracellular matrix , undulin , tenascin and fibronectin , in decalcified sections of human periodontal ligament ( PL ) and cementum . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have produced a set of bacterial expression proteins corresponding to 10 segments of tenascin and two of fibronectin and tested them for heparin binding and cell adhesion . ^^^ Heparin binding activity was mapped to two different tenascin segments : one comprising the fourth and fifth fibronectin type 3 domains , and to TNfbg , the fibrinogen like terminal knob . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The predicted amino acid sequence showed a structural architecture very similar to tenascin : a cysteine rich amino terminal region is followed by 4 . 5 epidermal growth factor like repeats , 9 fibronectin type 3 homologous repeats and a domain homologous to fibrinogen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Sequence analysis of two human tenascin encoding cDNA clones from a cDNA library of the U 251 glioblastoma cell line revealed the presence of a novel 276 bp tenascin type 3 fibronectin like repeat . ^^^ These results show that tenascin has at least 16 consecutive fibronectin like type 3 repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cellular fibronectin and tenascin in an orbital nylon prosthesis removed because of infection caused by Staphylococcus aureus . ^^^ By using the indirect immunofluorescent method , this tissue was found to react with monoclonal antibodies ( Mabs ) against extradomain A of cellular fibronectin ( EDA cFN ) and tenascin ( TN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These proteins include an alternatively spliced form of fibronectin , tenascin , and the proteoglycan biglycan . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Furthermore , bFGF and TGF beta 1 have an additive effect on levels of tenascin , but not fibronectin , in the conditioned medium . ^^^ Thus bFGF , alone or in combination with TGF beta 1 , is a potential regulator of tenascin expression in vitro . bFGF may alter not only the relative abundance of tenascin and fibronectin in the extracellular matrix , but also the splice variant of tenascin expressed by a given cell type . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The immunohistochemical distribution of tenascin ( TN ) , fibronectin ( FN ) , and laminin ( LN ) was investigated in 56 human gliomas ( 8 astrocytomas , 15 anaplastic astrocytomas , and 33 glioblastomas ) with regards to the histological degree of malignancy and the degree of tumor cell differentiation evaluated by the staining of glial fibrillary acidic protein ( GFAP ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The deduced protein of 782 amino acids contains eight tenascin type EGF like repeats not described in Drosophila before , but lacks the fibronectin type 3 repeats and the fibrinogen homology present in the vertebrate tenascin molecules . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution and alterations in the expression of fibronectin , laminin , and especially of tenascin , were compared between in vitro and in vivo studies with rat epithelial ( hepatocyte derived ) and nonepithelial ( sarcoma derived ) cell lines . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin , laminin and fibronectin following traumatic rupture of the anterior cruciate ligament ] . ^^^ In the present study , the pattern of some extracellular matrix glycoproteins was determined in traumatic anterior cruciate ligament ruptures ( n = 17 ) and in normal ligaments ( n = 11 ) . 6 microns cryo sections were incubated with monoclonal antibodies recognizing tenascin , laminin , and fibronectin , and FITC labeled secondary antibodies . ^^^ Immunohistochemistry revealed that tenascin , fibronectin and laminin are sparsely distributed in normal anterior cruciate ligaments , but strongly expressed in ruptured ligaments with a time restricted pattern . ^^^ The de novo expression of tenascin appeared before laminin but later than fibronectin . ^^^ The data suggest that fibronectin and tenascin are important , partially antagonistic components during healing processes after anterior cruciate ligament ruptures . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Frozen samples of minimal change glomerulopathy ( MCG ) , and of membranous , segmental and diffuse lupus glomerulonephritis ( MGN , SGN , DLGN ) were studied to assess the distribution of tenascin ( Ten ) , and the extradomains A and B ( EDA and EDB ) and oncofetal ( Onc ) isoforms of cellular fibronectin ( cFn ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As compared to fibronectin , there is a similar location of tenascin and fibronectin around tumor cell clusters but not in myxoid and chondroid matrices . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We present immunolocalization data on tenascin ( Ten ) , and extradomains A and B ( EDA , EDB ) and oncofetal ( Onc ) isoforms of cellular fibronectin ( cFn ) , and alpha 1 6 and alpha 5 and beta 1 4 integrin subunits on cryosections of normal human breast , the spectrum of fibrocystic disease ( FCD ) , and benign and malignant breast neoplasms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of tenascin in the thymus was more restricted than that of fibronectin and laminin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
There was a heavy signal for tenascin and fibronectin throughout the dermis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using several monoclonal antibodies binding to distinct epitopes on the tenascin molecule , we have identified two domains responsible for growth cone repulsion , on epidermal growth factor ( EGF ) like repeats 3 5 and fibronectin type 3 homologous repeats 4 and 5 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The extracellular matrix molecules tenascin , laminin , and fibronectin , the cell adhesion molecule L 1 , and the lectin concanavalin A ( ConA ) were tested for their effects on neuritogenesis in cultures of hippocampal neurons . ^^^ When the extracellular matrix molecules tenascin , laminin , and fibronectin were coated on polyornithine substrates , growth of all neurites was faster than on control substrates during the first hours of culture . ^^^ Spreading of neuronal cell bodies was reduced by about 50 % on tenascin , laminin , and fibronectin and by less than 20 % on L 1 and ConA substrates after 21 hr of culture , when compared to the control substrate . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In order to assess the biological significance of altered expression and deposition of ECM glycoproteins for human ADPKD at molecular levels fresh frozen tissue from ADPKD kidneys , fetal kidneys and normal adult kidneys were comparatively tested by immunohistochemistry for the presence of multifunctional ECM glycoproteins undulin , tenascin and fibronectin , interstitial collagen types 1 , 3 and 6 and intrinsic basement membrane components laminin and collagen type 4 using monoclonal antibodies and polyclonal antisera . ^^^ Studies were especially focused on ECM glycoproteins undulin and tenascin which in connection with interstitial collagens and fibronectin have specific structural and functional roles in tissue development and differentiation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The attachment of endothelial cells to tenascin results in elongated cells with interconnecting processes and is distinct from the flattened appearance of endothelial cells on fibronectin , collagen , vitronectin or laminin substrata , suggesting a role for tenascin in modulating cell adhesion and motility . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin is a major extracellular matrix glycoprotein that can interfere with the action of fibronectin by inhibiting cell adhesion and spreading . ^^^ In reactive lymph nodes , tenascin was mainly found in T dependent zones , forming a variably close woven reticular network corresponding to fibroblastic reticulum cells and blood vessels basal laminae , showing a partial co localization with fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Wounding was associated with alterations in extracellular matrix proteins , namely , loss of laminin and type 4 collagen in the region of the wound and expression of tenascin and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A series of peptides of 15 amino acids with sequences contained in human extracellular matrix ( ECM ) proteins ( fibronectin , laminin A , laminin B 1 , tenascin , undulin , alpha 1 chain of type 4 and 8 collagen and alpha 2 chain of type 8 collagen ) have been synthesized . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A case of cirrhotic liver harbouring three atypical macroregenerative nodules and an hepatocellular carcinoma was immunocytochemically investigated for the expression of VLA beta 1 , VLA alpha 2 and VLA alpha 5 integrins and for different extracellular matrix ( ECM ) components ( collagen 1 , collagen 4 , laminin , fibronectin and tenascin ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin was also seen in areas similar to those of tenascin and in the adjacent stroma . ^^^ Tenascin was found in oncocytoma as a focal staining , and fibronectin was seen around the basement membrane and adjacent stroma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The production of extracellular matrix components such as laminin , Type 4 collagen , fibronectin , and tenascin during the formation of basement membrane in cultured epidermis dermis recombinant skin of 13 day old chick embryo was analyzed immunohistochemically . ^^^ Fluorescence labeling of laminin and fibronectin appeared somewhat earlier than that of Type 4 collagen and tenascin . ^^^ Furthermore , fibronectin and tenascin were also distributed in the extracellular matrix of the dermis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin , laminin and Type 6 collagen were expressed in all cartilages but there was restricted expression of tenascin , ED A and ED B fibronectin isoforms ( articular cartilage and meniscus ) , and vitronectin ( absent from growth plate cartilage ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
For the assessment of ECM proteins 8 monoclonal antibodies ( Moabs ) versus fibronectin , its neoplastic isoforms , tenascin , type 4 collagen , laminin were used . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A modification of the expression pattern in laminin and collagen 4 and an increased expression of tenascin and fibronectin were also observed . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It is the same situation at the beginning of the evolution of the multicellular animals where fibronectin , tenascin and then laminin are present . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the kidney , TGF beta promotes tubuloepithelial cell hypertrophy and regulates the glomerular production of almost every known molecule of the extracellular matrix , including collagens , fibronectin , tenascin , and proteoglycans , as well as the integrins that are the receptors for these molecules . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The distribution of the integrin subunits is compared with that of the extracellular matrix ( ECM ) proteins types 4 and 3 collagen , laminin , fibronectin , tenascin and vitronectin , known to be present in reticular fibers of the spleen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These cells belonged to the family of connective tissue forming cells since they synthesized interstitial collagens 1 , 3 , and 5 ; nonplasmatic EDa+ and EDb fibronectin ; tenascin ; and chondroitin sulfate . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Smooth muscle cells produce and secrete matrix proteins such as tenascin , fibronectin , collagens and proteoglycans , and thereby induce a marked increase of the neointimal plaque volume . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cultured astrocytes deposit an extracellular matrix which has been shown by immunocytochemistry to react with antibodies to tenascin , laminin , and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This immunohistochemical investigation deals with the age dependent localization and distribution of types 1 , 3 , 4 , 5 , and 6 collagen and the structural glycoproteins undulin , fibronectin , laminin , tenascin , and vitronectin in the connective tissue of the human uterine tube . ^^^ Moreover , the structural glycoproteins undulin , fibronectin , laminin , tenascin , and vitronectin were detected in the mucosal stroma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Colonies from both fibrotic and neonatal lines were shown to be positive for vimentin , laminin , fibronectin , fibronectin receptor , beta actin , and tropomyosin by immunohistochemistry but were negative for desmin , keratin , Factor 8 , alpha smooth muscle cell actin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Extracellular matrix markers of TGF beta 1 activity , a special isoform of fibronectin , tenascin , biglycan and plasminogen activator inhibitor 1 , were significantly elevated in kidneys undergoing fibrosis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The sarcomatous components produced an extracellular matrix immunoreactive to fibronectin , type 1 , 3 and 6 collagens and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical techniques were applied for the detection of ECM molecules fibronectin , laminin , tenascin , vitronectin and integrins alpha 5 and beta 4 . ^^^ Results : Poorer differentiation of the tumours was characterised by up regulation of fibronectin , tenascin and vitronectin and downregulation of laminin and both integrins . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Type 4 collagen and tenascin were produced from the mesenchymal compartment , whereas laminin and fibronectin were contributed by both cell types . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In contrast , expression of additional tumor suppressor genes , such as the RB gene and p 53 , or genes associated with tumorigenesis in other model systems , such as major excreted glycoprotein ( MEP ) , 72 kDa gelatinase / type 4 collagenase ( 72 kDa GEL ) , fibronectin ( FIB ) , tenascin and intracellular adhesion molecule 1 ( ICAM 1 ) is not altered in a consistent manner during in vitro transformation suppression or escape from tumorigenic and metastatic suppression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This includes effects on the synthesis and secretion of thrombospondin , fibronectin , tenascin , etc . ^^^ The secretion of extracellular matrix glycoproteins themselves and incorporation into extracellular matrix in vitro appear to be linked to the activity of the autocrine feedback loops : e . g . , stimulation of thrombospondin mRNA results in secretion of the glycoprotein only in the concomitant presence of exogenous platelet derived growth factor , whereas the expression of fibronectin and tenascin may be directed by transforming growth factor beta . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Stromal epithelial interactions as expressed by alpha smooth muscle actin ( alpha SM actin ) collagen type 4 , fibronectin , laminin and tenascin were studied in normal and pathological endometrial mucosa . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We focus on the angiotensin 2 modulated expression of extracellular matrix glycoproteins , e . g . thrombospondin , tenascin , fibronectin and laminin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The initiation of the fibrosing process was assessed by the visualization of matrix molecules involved in targeting ( p fibronectin ) , organizing ( cellular fibronectin and tenascin ) and stabilizing ( lysyl oxidase ) the fibrogenic activity . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By contrast , on day 0 , the fibers were classified into two types with respect to myosin ATPase activity . 2 ) Immunohistochemical analysis indicated that the distribution of the components of the extracellular matrix in the epimysium ( type 1 collagen ) , perimysium ( type 1 collagen , fibronectin , and laminin ) and endomysium ( type 3 collagen , fibronectin , laminin , and tenascin ) was related to the metabolic capacity on days 12 to 13 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin and tenascin , both possible ligands for alpha 5 beta 6 integrin , were found concentrated underneath the basal epithelial cells expressing this receptor , and the maximal expression of tenascin coincided with that of alpha 5 beta 6 integrin . ^^^ Our results suggest that the expression of alpha 5 beta 6 integrin , a putative binding integrin for fibronectin and tenascin , is induced in keratinocytes when epithelial sheets fuse during wound healing . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Frozen sections and paraffin embedded sections were stained with antibodies to type 4 collagen , laminin ( LN ) , fibronectin ( FN ) , vitronectin ( VN ) , tenascin ( TN ) , fibronectin receptor ( FNR ) , and vitronectin receptor ( VNR ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunocytochemistry and immunoblotting showed that rocky astrocytes were enriched in tenascin and chondroitin 6 sulfate containing proteoglycans , but not in laminin or fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This effect of 6B4 proteoglycan on the neurite extension of cortical neurons was apparent even on coverslips co coated with fibronectin or tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Finally , photographic series , microsurgical manipulations , electron microscopy , and staining for molecules of the extracellular matrix ( peanut agglutinin binding components , tenascin , chondroitin sulfate proteoglycans , fibronectin , laminin ) suggest that several factors contribute to establishing and maintaining the melanophore free region , including steric effects of the lateral lines , interactions between melanophores and xanthophores , lateral line dependent alterations of the subepidermal basement membrane , and a general elaboration of the extracellular matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunocytochemistry on ultrathin sections was performed with antibodies to collagen Types 1 , 3 , 5 , 6 and 8 , fibronectin , laminin , P component and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Other major ECM abnormalities in PBK / ABK corneas compared to normals included : discontinuous epithelial BM straining for laminin 1 ( alpha 1 beta 1 gamma 1 ) , entactin / nidogen and fibronectin ; accumulation of fibronectin and alpha 1 alpha 2 type 4 collagen on the endothelial face of the Descemet ' s membrane ; and abnormal deposition of stromal ECM ( tenascin , fibronectin , decorin , types 1 , 3 , 5 , 6 , 8 , 12 , 14 collagen ) and BM components ( type 4 , collagen , perlecan , bamacan , laminin 1 , entactin nidogen , fibronectin ) in SEF areas and in PCL . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To gain insight into their differentiation process , we studied the expression of ( 1 ) markers of continuous endothelia , absent from adult sinusoidal endothelial cells ( PECAM 1 , CD 34 , and 1F10 ) ; ( 2 ) functional markers of adult sinusoidal endothelial calls ( CD 4 , 1CAM 1 , CD 32 , and CD 14 ) ; and ( 3 ) extracellular matrix components ( laminin , tenascin , fibronectin , and thrombospondin ) in 37 fetuses of different gestational ages . ^^^ We identified two successive differentiation events . ( 1 ) An early structural differentiation , occurring from 5 to 12 weeks of gestation , was characterized by the loss of continuous endothelial cell markers and a reduction in the perisinusoidal amount of laminin and in the deposition of tenascin , fibronectin , and thrombospondin ; at the end of this process , fetal liver sinusoids present structural characteristics comparable to those of the sinuses in adult hematopoietic bone marrow . ( 2 ) A later functional differentiation was characterized by the acquisition of the markers of adult sinusoidal endothelial cells , initiating at 10 weeks of gestation and completed by 20 weeks of gestation ; this process likely contributes to adapt liver sinusoids to the specific functions of the adult hepatic tissue . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of a series of ECMs laminin , type 4 collagen , heparin sulphate proteoglycan , fibronectin , tenascin , decorin , and vitronectin was immunohistochemically examined . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These include changes in the distribution of collagen types 1 , 2 , 3 , 4 and 6 ; the proteoglycans decorin and lumican ; as well as the adhesive glycoproteins tenascin , fibronectin and laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition to previously described stimulatory effects on collagen types 1 and 3 , fibronectin , undulin , and proteoglycan gene expression , TGF beta also dose dependently increased synthesis and secretion of tenascin , laminin , entactin , collagen type 4 , and alpha 2 macroglobulin , but decreased C 1 esterase inhibitor production by Ito cells , as revealed by immunoprecipitation of endogenously labeled proteins and by Northern blot analysis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The interdigital spaces exhibit a complex scaffold of extracellular matrix with well defined domains of spatial distribution of type 1 and type 6 collagens , tenascin , fibronectin , laminin and elastic matrix components that have been proposed to play a role in the establishment of the non chondrogenic fate of the interdigital tissue in situ . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In short term adhesion assays ( 1 hr ) , cerebellar and hippocampal neurons adhered to several domains , encompassing the fibronectin type 3 like ( FN 3 ) repeats 1 2 and 6 8 , as well as to the alternatively spliced FN 3 repeats and to tenascin itself . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By immunostaining of cultured cells , we found that the expression and distribution pattern of desmin and some extracellular matrix molecules , such as fibronectin , laminin and tenascin , had been changed after induction , and these changes were associated with the morphological changes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Moreover , studies on adhesion of the cell lines on coated substrates of fibronectin ( FN ) , laminin ( LN ) , tenascin ( TN ) , TN / FN and TN / LN showed that all the cells adhere and spread well on FN and LN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin ( FN ) , tenascin ( TN ) , collagens 1 and 6 , and a chick aggrecan stimulated migration in both types of embryos . ^^^ Fibronectin ( FN ) , tenascin ( TN ) , collagens 1 and 6 , and a chick aggrecan stimulated migration in both types of embryos . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We analyzed the expression of other extracellular matrix proteins by Western and Northern blot analyses , and found that adhesion molecules , fibronectin , and type 1 collagen , were increased , whereas an anti adhesion molecule , tenascin , was decreased , like decorin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
When isolated matrix components were immobilized on nitrocellulose and incubated with fibroblast conditioned medium , LTBP 1 from the medium associated with cellular fibronectin but not with heparan or chondroitin sulfate , vitronectin , tenascin , laminin , or collagen 1 or 4 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Binding of contactin / F11 to the fibronectin type 3 domains 5 and 6 of tenascin is inhibited by heparin . ^^^ The binding site on tenascin C for contactin / F11 is shown to span the two fibronectin type 3 homology domains 5 and 6 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunomorphological examination of human 6 8 days old cultures revealed that microtubules , actin and vimentin filaments and filaments of extracellular matrix : fibronectin and tenascin preferentially oriented in parallel with long axes of cell bodies . ^^^ Depolymerization of microtubular system by colcemid and its disorganization by taxol lead to rapid and drastic changes in morphology of all cytoskeletal systems and in the organization of matrix network : fibronectin and tenascin filaments became disordered and , in particular , lost any orientation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin expression in healing human myocardial scars . ^^^ Fibronectin and tenascin are matrix proteins known to be present in early experimental wound healing . ^^^ As only limited data are available regarding early matrix changes in human myocardial infarction , the presence of tenascin and fibronectin was studied in human myocardial infarctions of different post infarction times ( 6 h to 17 years ) , using immunohistochemistry . ^^^ While fibronectin was demonstrated in the ischaemic cardiomyocytes within 1 day , tenascin was found 4 6 days post infarction and was located at the margin of the area of infarction . ^^^ By that time , both tenascin and fibronectin expression had disappeared . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
If the basement membrane is disrupted , the epidermis migrates over a provisional matrix that contains fibrinogen , fibronectin , vitronectin and tenascin . ^^^ Although alpha 5 beta 1 integrin , a fibronectin receptor , is expressed by human epidermis during re epithelialization of excisional and incisional wounds , the spatial and temporal patterns of vitronectin , tenascin , and other fibronectin receptors are less clear . ^^^ Other potential receptors include alpha 5 beta 5 for vitronectin and alpha 5 beta 6 for fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin and integrins alpha 3 and beta 4 were found in or near the UBM area , with types 1 and 3 collagen and tenascin abutting the area . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The integrin alpha 8 beta 1 is a receptor for fibronectin , tenascin , and vitronectin that has been localized to axonal tracts and several types of non neuronal cells in chick embryos and to smooth muscle cells in adult mammalian tissues . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
For example , at least 5 different integrins recognize tenascin as a ligand , and 4 of these bind to the same region of the protein , the third fibronectin type 3 repeat ( TNfn 3 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In contrast to the surrounding aponeurosis as extracellular matrix , components of the whole proliferative noduli were defined : ED A , ED B and de novo glycosylated fibronectin , B 1 and B 2 laminin chain , tenascin and collagen type 4 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Between 8 and 20 weeks of gestation , fibronectin and tenascin were colocalized throughout the entire mesenchyme . ^^^ In adult mucosa , fibronectin was distributed at all levels of surface and glandular epithelium , whereas tenascin expression was restricted to surface and pit epithelial cells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Descemet membrane was severely attenuated , and there was a thick posterior collagenous layer consisting of numerous fibroblast like cells in a fibrillar extracellular matrix ; ultrastructural immunocytochemistry showed this to contain tenascin , fibronectin , and collagen type 1 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The spatial and temporal expression patterns of several extracellular matrix molecules laminin and fibronectin and cell surface molecules , neural cell adhesion molecule ( NCAM ) , L 1 , tenascin , chondroitin sulfate proteoglycan , and peanut agglutinin ( PNA ) binding sites were investigated during early olfactory nerve development . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Isolated cells displayed a differentiated phenotype , including the second passage in culture ; they synthesised collagen 1 , 3 , 4 , fibronectin , vitronectin , tenascin and chondroitin sulphate and expressed an atypical angiotensin receptor . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Heterogeneous distribution of fibronectin , tenascin C , and laminin immunoreactive material in the cumulus corona cells surrounding mature human oocytes from IVF ET protocols evidence that they are composed of different subpopulations : an immunohistochemical study using scanning confocal laser and fluorescence microscopy . ^^^ Monoclonal antibodies and immunofluorescence microscopy , including laser confocal microscopy , were used in this study to point out the production of fibronectin , tenascin c , and laminin in the cumulus corona ( CC ) cells surrounding mature human oocytes from IVF ET protocols in view of their presumptive importance in the coordination of the processes leading to fertilization and early embryo cleavage , including the final maturation of the ovum , the sperm egg interaction , and the `` complex biochemical dialogue ' ' between the gamete and the oviduct through the tubal luminal environment . ^^^ Specimens were incubated with a panel of primary monoclonal antibodies ( mabs ) recognizing different epitopes of fibronectin , tenascin c , and laminin and then with fluorescein isothiocyanate conjugated goat anti mouse IgG . ^^^ The immunohistochemical data demonstrated that human CC cells are capable of producing fibronectin and tenascin c but that their production is not homogeneous in the CC population . ^^^ In fact , fibronectin immunoreactivity was shown mostly by inner CC cells ( mainly corona cells ) , whereas tenascin was produced by some cells scattered in the entire cumulus mass . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Intrablastocoelic injections of several probes including antibodies to FN or integrin alpha 5 beta 1 , competitive peptides to the major cell binding site of FN or the antiadhesive protein tenascin all block mesodermal cell migration . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Comparison of the integrins involved in U251 . 3 cell migration on fibronectin or tenascin using a panel of integrin blocking MAbs including MAb L1A3 showed that only a subset of integrins participating in cell adhesion is essential for cell migration and these integrins appear to be ligand specific . ^^^ Fibronectin mediated tumor cell migration was critically dependent on alpha 5 integrins as shown by L1A3 blocking of migration while the beta 1 integrins were absolutely necessary for tenascin mediated cell migration . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
At 12 weeks there was a significant increase in interstitial immunostaining for collagen 1 , collagen 3 , collagen 4 , fibronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical methods were used to demonstrate the following wound healing proteins : cellular fibronectin , tenascin , transforming growth factor beta 1 , and alpha smooth muscle actin . ^^^ Restricted expression of fibronectin and tenascin was found at the wound area . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Condensations form following activation of at least three pathways : ( 1 ) Initiation of epithelial mesenchymal interactions by tenascin , BMP 2 , TGF beta 1 and Msx 1 and 2 . ( 2 ) Up regulation of N CAM by activin . ( 3 ) Up regulation of fibronectin by TGF beta , further enhancing N CAM accumulation ( Fig . 3 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin . ^^^ In migration / invasion Transwell assays U251 . 3 glioma cells rapidly migrated through the 8 mu m pore size membranes onto tenascin and fibronectin coated surfaces . ^^^ In this assay the number of cells migrating onto tenascin was 52 . 2 + / 9 . 6 % greater than on fibronectin within 4 hours . ^^^ The radial distance migrated by U251 . 3 cells from tumor spheroids was found to be 53 . 8 + / 4 . 9 % greater on tenascin than on fibronectin . ^^^ Cells migrating on tenascin display a very motile appearance , while cells migrating on fibronectin spread and maintain close intercellular contacts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The spindle cell compartment was rich in collagen , laminin , fibronectin and tenascin suggesting an important reactive component in the evolution of Kaposi ' s sarcoma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In order to investigate these mechanisms , expression of extracellular matrix molecules ( ECM ) ( undulin , decorin , tenascin , laminin , and fibronectin ) and cytokines [ transforming growth factor ( TGF ) beta 1 , TGF beta 3 , platelet derived growth factor ( PDGF ) , and PDGF receptor ] were semiquantitatively evaluated in chronically rejected lung allografts , using standard immunohistochemical techniques . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using single and double immunohistochemical staining techniques , all specimens investigated showed increased deposition of the ECM proteins fibronectin , tenascin , undulin , and collagen 6 with a characteristic densification especially in pericentral areas . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
When Jurkat T lymphocytes loaded with the calcium sensitive fluorescent dye fura 2 were placed on coverslips coated with human fibronectin , human collagen types 1 , 4 , and 6 , human tenascin , human laminin 1 , or mouse laminin 1 , an elevation in intracellular Ca2+ concentration was observed . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
IL 6 has been found to be a potent inhibitor of melanoma A 375 C6 cell adhesion , in addition to its known action in arresting cells at G1 / G0 phase of the cell cycle IL 6 treated melanoma cells were found to round up and to lose the ability to adhere to fibronectin , laminin , collagen , and tenascin over 72 to 96 hours of IL 6 treatment , a time course similar to that seen for cell cycle inhibition . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
OBJECTIVE : To compare in vitro expression of beta 1 , beta 3 , and beta 4 integrins in normal fibroblast like synoviocytes ( FBS ) and in FBS from rheumatoid arthritis ( RA ) synovium and to investigate the adhesion of normal FBS and RA FBS to the integrin binding extracellular matrix ( ECM ) proteins : collagen type 4 , fibronectin , laminin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Both collagenase 3 and Delta 249 451 collagenase 3 hydrolyzed the large tenascin C isoform , fibronectin , recombinant fibronectin fragments , and type 4 , 9 , 10 , and 14 collagens ; thus , these events were independent from C terminal domain interactions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Collagen 4 , fibronectin , and tenascin stimulated macrophages ' MMP 9 expression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This study reports the expression of laminin , fibronectin , thrombospondin , tenascin , and CD 44 in rhabdomyosarcoma cells taken from tumors derived from 12 pediatric patients . ^^^ All tumors demonstrated positive staining for tenascin and thrombospondin , 10 were positive for fibronectin , 5 positive for laminin , and 4 positive for CD 44 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Localization and distribution of both collagen ( types 1 , 3 , 4 , 5 , 6 ) and glycoproteins ( undulin , fibronectin , laminin , tenascin , vitronectin ) in the blood vessels of the human uterine tube were investigated immunohistochemically . ^^^ Furthermore , the glycoproteins fibronectin , laminin , tenascin and vitronectin were also detected . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The extracellular matrix molecules fibronectin and tenascin were located upon the surface of both implanted materials . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The macroscopic arrangement of the termination of the thoracic duct ( TD ) was examined in detail in Japanese cadavers , and the distribution of various types of collagen , tenascin , laminin , and fibronectin in the framework of the wall of the thoracic duct termination was demonstrated . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of tenascin and fibronectin in keratoconus , scarred and normal human cornea . ^^^ BACKGROUND : The etiology and pathogenesis of keratoconus remain unclear , and therefore we decided to study the distribution of different isoforms of tenascin ( Tn ) and fibronectin ( Fn ) in normal human corneas and in those obtained from penetrating keratoplasty for keratoconus and corneal scarring . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Unlike denervated adult muscle , there were no junctional accumulations of fibronectin or tenascin , matrix molecules produced by interstitial cells , in developing muscles . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The present article addresses the expression of selected extracellular matrix proteins ( collagen 4 , laminin , fibronectin , and tenascin ) and their respective receptor beta 1 integrins ( alpha 2 , alpha 3 , alpha 5 , and alpha 9 ) in glomeruli with LCDD and AL Am by immunohistochemical methods . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Schwann cells play an indispensable role in promoting regeneration by increasing their synthesis of surface cell adhesion molecules ( CAMs ) , such as N CAM , Ng CAM / L1 , N cadherin , and L2 / HNK 1 , by elaborating basement membrane that contains many extracellular matrix proteins , such as laminin , fibronectin , and tenascin , and by producing many neurotrophic factors and their receptors . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Hydrocortisone treatment modifies the distribution of two out of three chondroitin sulphate proteoglycan epitopes tested , as well as the shapes of the feathers and nerve arcades , but not fibronectin , tenascin or laminin localizations . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical analysis of 15 cases of ACC was done using antibodies to laminin , type 4 collagen , fibronectin , tenascin and anti proliferating nuclear antigen ( PCNA ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Placental infarcts revealed different immunoreactivities in the infarct margin and centre : high molecular CKs , tenascin , Ki 67 and oncofoetal fibronectin predominated in the infarct margin , low molecular CKs , fibrin and integrins in the centre . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The fluorescence and reflected light , conventional and scanning optical microscopy of excised osteoarthritic tissue preparations , from human and animal sources , has enabled the identification of cell proteins such as S 100 , of matrix components such as the proteoglycans and collagens , and of adhesion molecules including fibronectin , the integrins and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Thus , we investigated the deposition of extracellular matrix components ( laminin , fibronectin EIIIA , collagen 1 and 4 , procollagen 3 , elastin , tenascin ) as well as the expression of lysyl oxidase and of alpha SM actin in the portal zone at 24 , 48 , and 72 hours and 7 days after ligation of the common bile duct . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunoprecipitation and immunoblotting of the culture medium with monoclonal antibodies demonstrated a rapid onset of synthesis and secretion of Mr 280 , 000 tenascin ( Tn ) polypeptide with TPA and both Mr 280 , 000 and 190 , 000 Tn polypeptides with RA and an increased secretion of extradomain A cellular fibronectin ( EDA Fn ) upon both treatments . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
MC consistently adhered better than mesothelioma cells to laminin , tenascin , fibronectin and collagen type 4 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Most of the changes in the immunofluorescence deposition of the glycoproteins tenascin and fibronectin EDA+ were in the tubulointerstitium and vessels of the kidneys of rats on a LSD and were mostly significant at 28 days , in accordance with the characteristic histology of chronic CsA nephropathy . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Folding and stability of a fibronectin type 3 domain of human tenascin . ^^^ The folding of an isolated fibronectin type 3 domain of human tenascin , a large extra cellular matrix protein , has been characterised . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Backbone dynamics of homologous fibronectin type 3 cell adhesion domains from fibronectin and tenascin . ^^^ The tenth type 3 domain from fibronectin ( FNfn 10 ) and the third type 3 domain from tenascin C ( TNfn 3 ) have 27 % sequence identity and share the same overall protein fold , but present the RGD motifs in different structural contexts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) plays an important role in the regulation of extracellular matrix ( ECM ) deposition by stimulating the synthesis of individual matrix proteins like tenascin and fibronectin . ^^^ The purpose of our present study was to evaluate the distribution of TGF beta in comparison to the deposition of tenascin , fibronectin , and collagen as major components of the ECM in cholesteatoma ( n = 12 ) by means of histochemistry and immunohistochemistry . ^^^ In corresponding sections , a marked expression of tenascin and fibronectin was seen manifesting as a continuous band along the epidermal stromal junction , extending to the deeper stroma . ^^^ These results suggest that TGF beta may be involved in the stimulation of the synthesis of tenascin , fibronectin , and collagen . ^^^ Furthermore , the enhanced expression of tenascin and fibronectin provides evidence for a deregulated cell matrix interaction in cholesteatoma associated with the enhanced proliferative process of cholesteatoma formation . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The deduced amino acid sequence ( 4135 residues ) reveals that this protein is composed of a succession of peptide motifs characteristic of the tenascin family : an amino terminal domain containing cysteine residues and heptads of hydrophobic amino acids , 18 . 5 epidermal growth factor like repeats , 30 fibronectin type 3 like ( FNIII ) domains , and a carboxyl terminal fibrinogen like motif . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To identify antigenic differences between gliomas and normal brain , we have immunohistochemically studied the expression of lymphocyte adhesion molecules ( ICAM 1 , ICAM 2 , ICAM 3 , VCAM 1 , E selectin and CD 58 ) , epidermal growth factor receptor ( EGFR ) and extracellular matrix proteins ( collagen 4 , fibronectin , laminin , merosin , tenascin and vitronectin ) in these tissues . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Strong or moderate staining for collagen types 1 , 3 , and 5 , tenascin , laminin , and fibronectin was observed in close association with the border of the bone matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
For this purpose , cutaneous nerve pattern and distribution of fibronectin , tenascin , and three epitopes of chondroitin sulfate proteoglycans ( CSPGs ) have been immunohistologically studied in the skin of the specific apteria of naked neck chick mutants , which lack feathers in the neck area , and in the tarso metatarsal zone of retinoic acid treated embryos where ectopic feathers grow . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Co expression of tenascin and fibronectin in epithelial and stromal cells of benign lesions and ductal carcinomas in the human breast . ^^^ Tenascin ( TN ) C and fibronectin ( FN ) , which are glycoproteins of the extracellular matrix ( ECM ) , are up regulated in cancer tissues , including breast cancer . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin are extracellular matrix glycoproteins expressed during morphogenesis and tissue repair . ^^^ In the present study bronchial biopsies were studied by the morphometric method of immunocytochemistry to reveal the distribution of different tenascin and fibronectin isoforms as well as the presence of inflammatory cells in the airway mucosa of patients with chronic asthma ( n = 32 ) and those with seasonal birch pollen sensitive asthma out of season ( n = 17 ) , both in comparison with healthy control subjects ( n = 12 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg Gly Asp ( RGD ) sequence , displayed on specific FNIII repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C adhering cells remained round , whereas they spread rapidly on a fibronectin substrate . ^^^ To analyze the structure function relationships of different domains of tenascin C , we used recombinant full length fibronectin like and fibrinogen like domains and various subdomains corresponding to the alternatively spliced regions of tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the uninjured spinal cord ( 1 ) GFAP was expressed in the wild type but not the mutant mice , while vimentin was expressed in astrocytes in the white matter of both types of mice ; ( 2 ) laminin and fibronectin immunoreactivity was localized to blood vessels and meninges ; ( 3 ) tenascin and chondroitin sulfate proteoglycan ( CSPG ) labeling was detected in astrocytes and the nodes of Ranvier in the white matter ; and ( 4 ) in addition , CSPG labeling which was generally less intense in the gray matter of mutant mice . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In parallel , IFN gamma reduced the levels of the ECM molecules tenascin , laminin , and fibronectin as evaluated by Western blot analysis and immunocytochemistry . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Because tenascin , together with fibronectin , is able to upregulate the expression of 92 kDa collagenase and stromelysin in fibroblasts , the matrix destruction and basement membrane damage in LS may partly be a consequence of an abnormal accumulation and synthesis of tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
FK 506 treated kidneys had a progressive increase in the expression of TGF beta 1 and matrix proteins ( biglycan , tenascin , fibronectin , and type 1 collagen ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha increased the synthesis of distinct extracellular matrix proteins , particularly of fibronectin and tenascin , but decreased collagen type 3 expression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Purified , activated forms of the MT MMP were shown to degrade fibronectin , tenascin , nidogen , aggrecan and perlecan . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The marrow fibrosis results from an increased deposition of various interstitial and basement membrane glycoproteins , including collagen types 1 , 3 , 4 , 5 and 6 , fibronectin , vitronectin , laminin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cleft palate formation in fetal Br mice with midfacial retrusion : tenascin , fibronectin , laminin , and type 4 collagen immunolocalization . ^^^ OBJECTIVE : This study tested the hypothesis that altered craniofacial morphology does not affect the expression of extracellular matrix ( ECM ) molecules such as fibronectin ( FN ) , laminin ( LN ) , type 4 collagen , and tenascin C ( TN ) but is associated with failure of palatal shelf elevation and fusion concomitant with cleft palate formation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Integrins are a family of cell surface receptors that bind fibronectin , tenascin , collagen , and other extracellular matrix proteins that are deposited rapidly in fetal wounds . ^^^ Integrin receptor protein expression was analyzed at each time point using immunohistochemistry with monoclonal antibodies specific for the receptors that bind fibronectin , tenascin , collagen , and laminin ( alpha 5 , alpha ( 5 ) , beta 6 , alpha 2 , alpha 3 , alpha 6 , and beta 4 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of fibronectin , laminin , tenascin , collagen 6 , and chondroitin sulfate proteoglycan was studied by immunofluorescence . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the grafts treated with nitric oxide donor , expression of insulin like growth factor , fibroblast growth factor , thrombospondins , fibronectin , and tenascin was reduced . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of certain key extracellular matrix ( ECM ) proteins , fibronectin , collagen type 1 , and tenascin was measured by flow cytometry . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The integrin alpha 8 beta 1 has been reported to bind to fibronectin , vitronectin , and tenascin C in cell adhesion or neurite outgrowth assays . ^^^ In binding , adhesion , and spreading assays , significant interactions were observed only to short fragments of tenascin C containing the third fibronectin type 3 repeat which contains an RGD sequence . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Samples of each tumor group were selected and examined by immunohistochemistry using mAbs , raised against integrin chains ( beta 1 , beta 4 , alpha 2 , alpha 3 , alpha 6 ) and their ligands laminin 1 and 5 , collagen type 4 , two fibronectin isoforms ( ED A and ED B ) and two isoforms of tenascin known to be associated with neoplasm . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using immunohistochemical and serum determinations of extracellular matrix constituents , including fibronectin , collagen type 4 , laminin , and tenascin , we showed consistent serum elevation and / or deposition of fibronectin , in each case , without a commensurate increase in laminin , collagen type 4 , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cartilage oligomeric protein may have value as a marker of turnover and degeneration of cartilage , and other noncollagenous proteins , including tenascin and fibronectin , can influence interactions between the chondrocytes and the matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In accordance with the delayed orthokeratinization , wound matrix molecules ( fibronectin , tenascin ) persisted longer than in normal keratinocyte transplants . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the lens capsule there is a compartmentalization of matrix components with fibronectin , primarily localized to the anterior capsule , and tenascin in the posterior capsule . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We also found similar results by studying recombinant tenascin fragments encompassing the 15 fibronectin type 3 domains of tenascin . ^^^ This indicates that the extensibility of tenascin may be due to the stretch induced unfolding of its fibronectin type 3 domains . ^^^ We suggest that the extensibility of the modular fibronectin type 3 region may be important in allowing tenascin ligand bonds to persist over long extensions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The effect of boundary selection on the stability and folding of the third fibronectin type 3 domain from human tenascin . ^^^ Folding and stability studies of the third fibronectin type 3 domain from human tenascin ( TNfn 31 90 ) have shown that it is moderately stable ( Delta G ( D N ) ( H2O ) approximately 5 kcal mol 1 ) and folds with two state kinetics . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The results are summarized as follows : ( 1 ) cytoskeletal elements : virtually all the MMS fibroblasts were stained positively for alpha sm actin while only a small fraction of BM and of NS fibroblasts were positive for this antigen ; ( 2 ) extracellular matrix elements : MMS fibroblasts stained positively for ED B fibronectin and tenascin while the other 2 fibroblast cell types did not ; ( 3 ) cell surface molecules : NS and MMS fibroblasts expressed significantly higher levels of ICAM 1 , VLA 4 and CD 9 than BM fibroblasts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The experiments are demonstrated using a 13C / 15N isotopically enriched sample of the third fibronectin type 3 domain of human tenascin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Pleiotrophin and poly L lysine coated on the substratums stimulated cell migration of cortical neurons , while laminin , fibronectin , and tenascin exerted almost no effect . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By utilizing recombinant bacteriophages that display overlapping regions of the third fibronectin type 3 repeat of tenascin C ( TNfn 3 ) , we were able to localize its alpha9beta1 integrin binding site to the B C loop of TNfn 3 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Exogenous L 1 or glioma motility factor 1 strongly stimulated the cell migration , whereas fibronectin , tenascin , and glioma motility factor 2 had little or no effect . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have analyzed the immunohistochemical expression of chondroitin sulfate proteoglycan ( CSPG ) , fibronectin ( FN ) , laminin ( LN ) , tenascin ( TN ) , and glial fibrillary acidic protein ( GFAP ) along the anterior commissure ( AC ) of hamster embryos ( n=175 ; from embryonic day ( E ) 12 to E 16 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin expression in human mesothelial cells and pleural mesothelioma cell line cells . ^^^ Fibronectin ( Fn ) and tenascin ( Tn ) are two major extracellular matrix ( ECM ) glycoproteins that may have important roles both in fibrotic lung diseases and in lung tumors . ^^^ Fibronectin ( Fn ) and tenascin ( Tn ) are two major extracellular matrix ( ECM ) glycoproteins that may have important roles both in fibrotic lung diseases and in lung tumors . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The dependence of chemical exchange on boundary selection in a fibronectin type 3 domain from human tenascin . ^^^ The third fibronectin type 3 domain from human tenascin adopts a compact beta sandwich fold . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin ( TN ) is an extracellular matrix protein which interferes with fibronectin ( FN ) dependent cell attachment and activation as a natural antagonist to FN action . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Our laboratory has focused on the increased activity of an endogenous vascular elastase in the pathobiology of pulmonary hypertension and on the mechanisms by which it is upregulated and by which it orchestrates abnormal remodeling of the vessel wall , specifically the induction of growth factors , the induction of the glycoprotein tenascin , which amplifies the proliferative response , and fibronectin , which is critical to the process of smooth muscle migration in the context of neointimal formation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The cytokine effects did not correlate with expression on astrocytes of laminin , fibronectin , tenascin , chondroitin sulphate proteoglycan , N cadherin , polysialyated NCAM ( PSA NCAM ) , tissue plasminogen activator ( tPA ) or urokinase ( uPA ) . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Abnormal depositions of collagen types 1 and 3 , fibronectin , and tenascin were also observed in fibrotic areas adjacent to dilated or atrophic tubules with thickened basement membranes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
All ECM molecules analyzed ( tenascin , laminin , fibronectin , collagen types 1 , 3 , 5 and 6 ) could be detected in bone marrow cryostat sections of multiple myeloma patients . ^^^ Adhesion assays with several B cell lines resembling earlier differentiation stages revealed only weak interactions with tenascin and no interactions with collagen type 6 , laminin or fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin , fibronectin , and laminin in rat liver fibrogenesis a comparative immunohistochemical study with two models of liver injury . ^^^ The aim of this study was to follow semiquantitatively by immunohistochemical means the alterations of the expression of the hepatic glycoproteins tenascin , fibronectin , and laminin in two different models of chronic liver injury , i . e . thioacetamide induced liver cirrhosis and fibrosis after bile duct ligation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
T cells , B cells , plasma cells , granulocytes and macrophages , and the ECM molecules fibronectin ( FN ) , chondroitin sulfate ( CS ) , and tenascin ( TN ) were visualized using immunohistochemical techniques . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A number of large multidomain extracellular matrix glycoproteins , including fibronectin and members of the tenascin and thrombospondin families , are expressed in locations that suggest they may be involved in the process of chondrogenesis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemistry for the extradomain A cellular fibronectin ( EDA cFn ) or tenascin ( Tn ) and routine histology were examined . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Addition of the ECM protein tenascin to the FN fibrin matrix induces a different cell morphology . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin as a promoter of migration and adhesion was abundant , its antagonist tenascin and chondroitin sulfate showed patchy localization . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Presence and distribution of collagen 2 , collagen 1 , fibronectin , and tenascin in rabbit normal and osteoarthritic cartilage . ^^^ OBJECTIVE : To investigate changes in the composition of articular cartilage matrix during the development of experimental osteoarthritis ( OA ) , collagen type 2 , collagen type 1 , and the noncollagenous proteins fibronectin and tenascin were studied in normal and osteoarthritic cartilage of rabbits . ^^^ Frozen sections of rabbit normal and OA cartilage were stained with monoclonal antibodies against collagen type 2 , collagen type 1 , fibronectin , and tenascin . ^^^ Collagen type 1 , fibronectin , and tenascin show enhanced deposition in the upper , fibrillated osteoarthritic cartilage , suggesting a common mediator controlled pathway . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have attempted to map this landscape for the third fibronectin type 3 domain from human tenascin ( TNfn 3 ) , a compact 9 . 5 kDa beta sandwich protein , through measurement of 15N backbone dynamics on the milli to picosecond timescale and a number of structural parameters . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
PURPOSE : To compare the concentrations of cellular fibronectin ( cFN ) , plasma fibronectin ( pFN ) , tenascin and calcitonin gene related peptide ( CGRP ) in the aqueous humour in primary open angle glaucoma ( POAG ) , exfoliative glaucoma ( EXFG ) or cataract ( control group ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Type 2 collagen , fibronectin , tenascin , chondroitin sulfate proteoglycans , alphav and beta 1 integrins were immunolocalized in the ECM of these connective tissue structures . ^^^ The glycoproteins fibronectin , tenascin and alphav integrin were immunolocalized mainly in the basilar membrane . ^^^ Collagen fibrils in the basilar membrane were also surrounded by a homogeneous matrix , which was immunoreactive to fibronectin and tenascin antibodies . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistological distributions of fibronectin , tenascin , type 1 , 3 and 4 collagens , and laminin during tooth development and degeneration in fetuses of minke whale , Balaenoptera acutorostrata . ^^^ The immunohistological distributions of fibronectin , tenascin , type 1 , 3 and 4 collagens , and laminin were observed in the tooth buds of fetuses of minke whale , Balaenoptera acutorostrata . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In this paper the structure and function of major adhesive proteins : fibronectin , tenascin , laminin and nidogen are reviewed . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
When mesangial cells are incubated with LCDD LCs , production of ECM proteins ( collagen 4 , laminin , fibronectin , and tenascin ) is increased , with maximum effect at 72 hours post LC treatment . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have performed an in depth study of transverse relaxation rates of backbone 15N nuclei in TNfn 3 ( 1 90 ) , the third fibronectin type 3 domain from human tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of N cadherin , N CAM , fibronectin and tenascin is stimulated by TGF beta 1 , beta 2 , beta 3 and beta 5 during the formation of precartilage condensations . ^^^ However , little is known about the relationship between adhesion molecules ( N cadherin and N CAM ) , extracellular matrix proteins ( fibronectin and tenascin ) and TGF beta 1 , TGF beta 2 and TGF beta 3 during in vitro precartilage condensations in mouse chondrogenesis . ^^^ To determine whether the effect of TGF betas on precartilage condensations is mediated through the expression of N cadherin , N CAM , fibronectin and tenascin , we evaluated their expression . ^^^ Results showed that TGF beta 1 , TGF beta 2 , TGF beta 3 , and TGF beta 5 differentially enhanced the expression of N cadherin , N CAM , fibronectin and tenascin in precartilage condensations , suggesting that TGF beta isoforms play an important role in the establishment of cell cell and cell extracellular matrix interactions during precartilage condensations . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Purification , crystallization and preliminary crystallographic studies of a two fibronectin type 3 domain segment from chicken tenascin encompassing the heparin and contactin binding regions . ^^^ A fragment of chicken tenascin consisting of fibronectin type 3 domains 5 and 6 has been expressed in Escherichia coli . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Of numerous purified matrix proteins tested , laminin 1 and tenascin inhibited cell attachment , whereas fibronectin , bone sialoprotein , and type 1 collagen increased cell attachment and others had no effect . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Composites with BM antigens present initially were significantly better than those initially lacking BM antigens in : ( 1 ) the degree of epithelial cell attachment to the underlying dermis ( hemidesmosomes were seen only in the former ) ; ( 2 ) the morphology of the epithelial layer ; ( 3 ) the consistent presence of collagen 4 and laminin and the increasing expression of tenascin ; and ( 4 ) the amount of soluble collagen 4 and fibronectin detected in the conditioned media . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C , undulin , collagen 14 and fibronectin are extracellular matrix glycoproteins with a partial DNA sequence homology . ^^^ Corresponding to the in vivo findings , tenascin C expression was increased in keloidal fibroblasts compared with normal fibroblasts in vitro ( P < 0 . 003 ) , whereas undulin / collagen 14 and fibronectin expression in keloids and keloidal fibroblasts was similar to that in normal tissue and normal fibroblasts , respectively . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistologic cellular fibronectin and tenascin were used as markers of early epithelial and stromal wound healing in the cornea . ^^^ After LASIK this reaction was limited to the peripheral entry point of the microkeratome blade around the edge of the corneal flap , where cellular fibronectin and tenascin reactions were positive . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Stroma of both tumors contained nidogen and high amounts of tenascin C , but only a few very low levels of fibronectin , laminin 1 , and collagen type 1 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Several structural glycoproteins , like fibronectin , laminin , entactin , tenascin , and undulin were detected using monoclonal antibodies . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : The expression pattern of the matrix proteins collagen 4 , fibronectin , laminin , tenascin , and undulin as well as the structure and orientation of elastic fibres were determined by means of immunohistochemical staining . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Lung fibroblasts upregulate tenascin and fibronectin production when treated with TGF beta 1 . ^^^ Expression of either TbetaRI deltaK or TbetaRII deltaK alone was sufficient to block TGF beta induced tenascin and fibronectin production of lung fibroblasts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This short review focuses mainly on the recognized roles played by proteoglycans , laminin , fibronectin and tenascin in axonal development during ontogenesis . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A computer image analysis of immunostained extracellular matrix ( ECM ) proteins ( collagen types 1 , 2 , 3 and 5 , fibronectin and tenascin ) in hypertrophic layers in the mandibular condyle and temporal bone of human fetuses , which ranged in gestational age from 12 to 32 weeks , was performed . ^^^ The extent of accumulation of fibrillar collagen and of fibronectin differed , while those of other proteins in the ECM , such as tenascin , osteocalcin and osteonectin , were similar at the two sites . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin , but not fibrinogen , inhibited binding , thus indicating a role of the fibronectin type 3 repeats in the interaction between the fungus and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C is an extracellular matrix glycoprotein whose monomers include eight consecutive fibronectin type 3 like repeats , encoded by exons 10 16 , and which are subject to alternative splicing . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : The synthesis of the basement membrane ( BM ) proteins entactin , laminin , and collagen type 4 and of the extracellular matrix ( ECM ) proteins tenascin and fibronectin with or without TGF beta 1 stimulation was analyzed by immunostaining , immunoprecipitation of endogenously labeled proteins and Northern blot analysis of total RNA extracted from freshly isolated or cultured SECs from rat or guinea pig livers . ^^^ Specific immunoprecipitates and specific transcripts for the BM proteins entactin , laminin , and collagen type 4 and for ECM proteins tenascin and fibronectin were detectable in freshly isolated or cultured SECs . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Four human glioblastoma cell lines ( U373MG , U138MG , U251MG , GaMG ) as well as four human melanoma cell lines ( MV 3 , BLM , 530 , IF 6 ) were tested with semiquantitative RT PCR for their ability to express mRNA of different human ECM components ( fibronectin , decorin , tenascin , collagen 1 , collagen 4 , versican ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Changes in the expression and distribution of fibronectin , laminin and tenascin by cultured fibroblasts from skin lesions of patients with tuberous sclerosis . ^^^ Fibronectin , laminin and tenascin play an important part in the assembly of the extracellular matrix and the interaction of cells with it . ^^^ Fibroblasts from three different tuberous sclerosis skin lesions ( forehead plaque , neck fibroma and ungual fibroma ) secreted more fibronectin and tenascin into their culture medium than did normal skin fibroblasts . ^^^ The proportions of fibronectin / laminin / tenascin secreted by the skin lesion fibroblasts were markedly different from normal . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : Distribution of integrins , laminin , type 4 collagen , tenascin , and fibronectin was immunohistochemically evaluated in 13 supraglottis carcinomas . ^^^ Normal and metaplastic epithelium was alpha5beta1 negative ; the stroma of primary and metastatic tumors was tenascin and fibronectin positive . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
KGF treated keratinocytes showed increased attachment to collagen types 1 and 4 and fibronectin , but , not to laminin 1 , vitronectin , or tenascin . ^^^ KGF also induced migratory phenotype and stimulated keratinocyte migration on both fibronectin and collagen types 1 and 4 but not on laminin 1 , vitronectin nor tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We show that the relative amounts of the glycoproteins laminin LN , fibronectin ( FN ) and tenascin ( TN ) are virtually identical in L and M glia , thus , confirming that an abundant content of LN is not sufficient to promote neurite growth . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In HC 11 mammary cells , we found that tenascin , but not laminin or fibronectin , specifically downregulated C / EBPalpha levels but had no effect on Stat 5 amount or DNA binding activity . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Extracellular matrix molecules , cell surface receptors and cell adhesion molecules , such as fibronectin , tenascin , syndecan , and N CAM , initiate condensation formation and set condensation boundaries . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The aim of this investigation was to study immunohistochemically the expression patterns of four ECM components : fibronectin , laminin , collagen 4 , and tenascin ( TN ) in human gliomas , with special attention to TN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition , we evaluate the localization of several other proteins involved in wound healing , including fibronectin , laminin beta 1 , nidogen / entactin , and VCAM 1 , in both the tenascin knockout and wild type mice . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical techniques were used to localize cytokeratin , vimentin , alpha smooth muscle specific actin , fibronectin , tenascin , and transforming growth factor beta ( TGF beta ) within plaques . ^^^ Fibronectin and tenascin were also detected in the extracellular matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The cytokine induced a myofibroblastic transformation of dermal cells , significantly enhanced the process of dermal contraction , and stimulated synthesis of such proteins as cellular fibronectin , tenascin and smooth muscle actin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Histologic sections from 27 patients who underwent LTR were cut , and immunohistochemical staining was performed for transforming growth factor beta , platelet derived growth factor , fibronectin , tenascin , transforming growth factor alpha , and vascular endothelial growth factor . ^^^ Results showed that patients with adequate wound healing capability had a positive correlation with vasculature fibronectin , vasculature tenascin , and stromal fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and elastin were predominantly found surrounding ducts whereas fibronectin had a more general distribution . ^^^ CONCLUSIONS : These results show that ( a ) there are no changes in glandular expression of tenascin , elastin and fibronectin in SSc and RP and ( b ) both conditions are associated with an increased salivary gland mast cell population and changes in expression of TGFbeta 2 and beta 3 isoforms by glandular fibroblasts . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
TNfn 3 , the third fibronectin type 3 domain of human tenascin , is an immunoglobulin like protein that is a good model for experimental and theoretical analyses of Greek key folding . ^^^ The third fibronectin type 3 domain of human tenascin folds and unfolds in a two state fashion over a range of temperature and pH values , and in the presence of stabilising salts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The in vivo phenotype was characterized by the loss of GFAP immunoreactivity , the gain of heterogeneously distributed cellular tenascin , fibronectin , and laminin , but absence of extracellularly deposited material , and by the formation of irregular vessels . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In tumor tissue specimens of 27 primary and 17 secondary glioblastomas and the precursor lesions , the immunohistochemical expression patterns of the membrane protein CD44s , the basal lamina proteins laminin , collagen 4 , and fibronectin , the lectin galectin 3 recognizing tenascin and N CAM as well as of the matrix degrading enzymes matrix metalloproteinase MMP 2 and MMP 9 , and cathepsin D were studied . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Mix 1 cells expressed vimentin , type 1 collagen , fibronectin , tenascin and hyaluronic acid . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using immunohistochemistry , we next examined the levels of the neural cell adhesion molecule ( NCAM ) , fibronectin , tenascin , and Reelin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Integrins beta 1 , beta 3 , beta 4 , beta 5 , fibronectin and tenascin were also studied . ^^^ Fibronectin and tenascin were present in the connective tissue underneath the epithelium of all the sections , and their expression was similar in both alpha ( 5 ) beta 6 positive and alpha ( 5 ) beta 6 negative tissues . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Thus , antibodies raised against extracellular matrix proteins , laminin , fibronectin , entactin or nidogen , tenascin , heparan sulfate proteoglycan , osteonectin , and Type 4 collagen reacted positively with basal lamina proteins . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have previously cloned the human integrin subunit alpha 8 , documented its high expression in lung tissue , and established it as a receptor for the matrix proteins fibronectin , vitronectin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Unaltered distribution of laminins , fibronectin , and tenascin in celiac intestinal mucosa . ^^^ We used immunohistochemistry to determine the distribution of laminin , fibronectin , and tenascin isoforms in small intestinal biopsies of untreated patients with celiac disease . ^^^ Likewise , the distribution of fibronectin and tenascin resembled that of the normal gut . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Quantitative invasion assays were performed using collagen gels , supplemented with either fibronectin , tenascin , collagen type 5 , collagen type 6 , chondroitin sulfate or keratan sulfate . ^^^ Addition of tenascin to the fibronectin containing gels disrupted these effects , while attachment to this matrix also involved the integrins alpha ( 2 ) beta ( 1 ) and alpha ( 3 ) beta ( 1 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of the extracellular matrix protein tenascin in laryngeal epithelial lesions : correlation with fibronectin , CD 44 , cathepsin D and proliferation indices . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
CD 44 , Type 4 Collagen ( Col 4 ) , Laminin ( LN ) , Fibronectin ( FN ) , and Tenascin ( TN ) expression were detected by immunohistochemistry in formalin fixed paraffin embedded tissue samples of 52 astrocytic tumors : 35 glioblastomas ( GB ) , 7 Anaplastic astrocytomas ( AA ) and 10 astrocytomas ( A ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C , a developmentally regulated matrix protein , modulates cellular responses to other matrix proteins , such as fibronectin ( FN ) . ^^^ Here , we report that tenascin C markedly altered cell phenotype on a three dimensional fibrin matrix containing FN , resulting in suppression of actin stress fibers and induction of actin rich filopodia . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Nine cases of mild ( group 1 ) and nine cases of severe ( group 2 ) transplant glomerulopathy were stained with antisera against fibronectin ( FN ) , tenascin ( TN ) , collagen types 3 and 4 , smooth muscle actin , CD45RO , CD 68 , and Ki 67 antigen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As part of a systematic study of the folding of protein structural families we compare the effect of mutation in two closely related fibronectin type 3 ( fnIII ) domains , the tenth fnIII domain of human fibronectin ( FNfn 10 ) and the third fnIII domain of human tenascin ( TNfn 3 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The specimens were compared with 36 specimens collected from six patients without varicosities , incubated with fluorescence stained antibodies for collagen 4 , laminin , fibronectin and tenascin prior to being assessed with confocal laser scan microscopy . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Forty five gliomas ( astrocytomas , glioblastomas , oligodendrogliomas , and mixed gliomas ) were investigated for the immunohistochemical expression of the membrane protein CD44s , the basal lamina proteins laminin , collagen 4 , and fibronectin , the lectin galectin 3 recognizing tenascin and N CAM , as well as for the matrix degrading enzymes metalloproteinases MMP 2 , MMP 9 , and cathepsin D . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Alterations in distribution of tenascin , fibronectin and fibrinogen in vulval lichen sclerosus . ^^^ Tenascin , fibrinogen and fibronectin are extracellular matrix components that play a significant role in tissue remodelling , for example during wound repair . ^^^ Aim : To examine the distribution of tenascin , fibrinogen and fibronectin in vulval lichen sclerosus . ^^^ MATERIALS AND METHODS : Immunohistochemical staining was performed to study the distribution of tenascin , fibronectin and fibrinogen in 16 specimens of untreated vulval lichen sclerosus and 1 specimen of extragenital lichen sclerosus . ^^^ CONCLUSION : The distribution of tenascin , fibrinogen and fibronectin is altered in lichen sclerosus and the alteration in these extracellular matrix components may be relevant to the initiation of scarring in lichen sclerosus and the associated increased skin fragility . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The following ECM proteins were detected immunohistochemically : collagens 1 , 3 , 5 and 6 , the glycoproteins fibronectin , tenascin and vitronectin , and the basement membrane protein laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
They undergo transformation into myofibroblasts and become the source of extracellular matrix proteins , such as : collagens , fibronectin , laminin , entactin , tenascin , undulin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical localization of type 1 collagen , fibronectin and tenascin C during embryonic osteogenesis in the dentary of mandibles and tibias in rats . ^^^ Type 1 collagen , fibronectin and tenascin C play an important role in regulating early osteoblast differentiation , but the temporal and spatial relationship of their localization during embryonic osteogenesis in vivo is notknown . ^^^ Serial paraffin sections were cut and adjacent sections were processed for von Kossa staining or immunohistochemistry for type 1 collagen , fibronectin and tenascin C . ^^^ The present study demonstrated characteristic localization of type 1 collagen , fibronectin and tenascin C during embryonic osteogenesis in the dentary of mandibles and tibias . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and fibronectin in benign epithelial hyperplastic lesions and squamous carcinoma of the larynx . ^^^ BACKGROUND : Tenascin ( T ) and fibronectin ( FN ) are glycoprotein components of the extracellular matrix presumably involved in cancer progression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin , laminin , collagen type 4 and tenascin were found in stroma of the lymphoid tissue . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition , a weak immunoreactivity for type 1 and type 3 collagen , and fibronectin was observed in some cases , whereas no globule stained for tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In fully developed lesions , mesangial and subendothelial accumulation of collagenous and noncollagenous glycoproteins normally expressed in the mesangial area ( types 4 [ alpha 1 ( 4 ) 2 alpha 2 ( 4 ) ] and 6 collagen , beta 1 laminin , fibronectin , tenascin , and perlecan ) increased with progression of mesangial sclerosis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Our model of fibronectin domain 3 13 was generated from a template of the three dimensional structure of a homologous ( 25 % identity ) domain , 3 3 , from tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical localization of tenascin , fibronectin , and type 3 collagen in human dental pulp . ^^^ The distribution of tenascin ( TN ) , fibronectin ( FN ) , and type 3 collagen ( col 3 ) in the extracellular matrix of the connective tissue of normal , inflamed , and hyalinized human dental pulp was studied by immunohistochemical staining with monoclonal antibodies against these molecules . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
PURPOSE : The distribution of the cell adhesion glycoproteins , laminin , fibronectin , tenascin , vitronectin , thrombospondin , and entactin / nidogen , was examined in the human lamina cribrosa . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The deposition of collagen 1 , 3 , 5 , fibronectin , tenascin , hyaluronan , versican and laminin alpha2 / beta2 is increased , whereas the deposition of collagen 4 and elastin is decreased . 4 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
LOX expression was observed at the tips of intra luminal fibrotic protrusions , together with tenascin and cellular fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The alpha 8 integrin subunit associates exclusively with the beta 1 subunit to form a receptor ( alpha8beta1 ) for fibronectin , vitronectin , tenascin , and osteopontin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Moreover , both the M and RT derived cells were found to express higher levels of the extracellular matrix ( ECM ) proteins collagen type 1 , fibronectin , tenascin , and decorin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical methods using antibodies to fibronectin , tenascin and metalloproteinases were used to assess the alterations of the instrinsic and extrinsic components of the basement membrane . ^^^ Collagen type 4 , tenascin , fibronectin , basic fibroblastic growth factor ( bFGF ) , and matrix metalloproteinases ( MMPs ) are related to the matrix , perimatrix of normal or pathological tissues . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition to the remarkable accumulation of mononuclear cells , the vascular associated lymphoid tissue regions are characterized by a typical distribution of extracellular matrix proteins : collagen type 1 , collagen type 3 , fibronectin and tenascin are expressed preferentially in the vascular associated lymphoid tissue region , whereas collagen type 4 , collagen type 5 , collagen type 6 and laminin show a homogenous distribution throughout all regions of the intima . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To determine whether SPARC alters the growth , attachment , or migration of gliomas , we have used U87T2 and doxycycline regulatable SPARC transfected clones to examine the effects of SPARC on ( 1 ) cell growth , ( 2 ) cell cycle progression , ( 3 ) cell attachment , and ( 4 ) cell migration , using growth curves , flow cytometry , attachment , and migration analyses on different brain ECMs , including collagen 4 , laminin , fibronectin , vitronectin , hyaluronic acid , and tenascin . ^^^ In comparison to the parental U87T2 clone , the SPARC transfected clones demonstrated increased attachment to collagen , laminin , hyaluronic acid , and tenascin , but not to vitronectin or fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
High expression of collagen , fibronectin , tenascin , and alpha 2 integrin was detected in the TGF beta 1 expressing tumors by immunohistochemistry . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To investigate possible relationships in the epithelium of the human adult small intestine we examined immunohistochemically the distribution of type 4 collagen , laminin , fibronectin and tenascin , and compared the sites of their expression with the various cell activities . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition we studied the production of some Extra Cellular Matrix ( ECM ) components such as Fibronectin , Tenascin and Collagen 1 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
With immunofluorescence techniques , we studied , during this process , the spatial and temporal pattern of expression of : transforming growth factor alpha ( TGF alpha ) ; transforming growth factor beta ( TGF beta ) isoforms 1 , 2 , and 3 ; platelet derived growth factor ( PDGF ) ; and the extracellular matrix proteins fibronectin , collagen 4 , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
All known molecular markers for human ASC were induced in both rodent models , including collagen types 1 and 3 , tenascin , and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This process takes place at the first week after birth of the rat and cell adhesion molecules such as neural cell adhesion molecule ( NCAM ) , fibronectin , tenascin and Reelin are also suggested to play an important role for the cell patterning . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies specific for major ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
BACKGROUND : During wound repair , fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin , cellular fibronectin and collagen 3 . ^^^ RESULTS : Here we show that this chemokine can stimulate precocious deposition of tenascin , fibronectin and collagen 1 , but not collagen 3 . ^^^ Fibronectin accumulation appears to be linked to tenascin production , and collagen 1 to decreased MMP 1 levels . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
An immuno histochemical study using laminin and type 1 , 3 and 4 collagens , fibronectin and tenascin antibodies was performed . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In addition , the presence of collagen ( type 1 and 3 ) , keratin , vimentin , fibronectin , tenascin , factor 8 related antigen , CD 31 and CD 45 was tested for by immunohistochemistry . ^^^ Only one specimen stained positively for connective tissue markers ( vimentin , fibrous fibronectin , tenascin ) or showed the presence of vascular epithelium . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical detection of fibronectin and tenascin in incised human skin injuries . ^^^ We studied the expression of fibronectin ( FN ) and tenascin ( TN ) in 58 human skin wounds ( 48 vital and 10 postmortem ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Pertubation of beta 1 integrin function using anti sense or function blocking antibodies on corneal cells grown on fibronectin and tenascin . ^^^ In the present studies , we have examined the interaction of beta ( 1 ) integrins on periocular mesenchyme cells ( POM ) and corneal fibroblasts ( CF ) with fibronectin and tenascin by perturbing the function of this integrin . ^^^ POM and CF attached and spread to a much greater extent on fibronectin than on tenascin . ^^^ An antibody against beta ( 1 ) integrin , CSAT , decreased spreading and attachment , and resulted in a lack of immuno detectable beta ( 1 ) integrin in focal adhesions on fibronectin ; few beta ( 1 ) positive focal adhesions were observed in cells grown on tenascin . ^^^ These data indicate that in vitro , both POM and CF have beta ( 1 ) integrins that interact with fibronectin and allow them to attach and spread , while tenascin is anti adhesive . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The right eyes were enucleated , and the corneas were studied with immunohistochemical evaluation for extracellular matrix , including collagen type 1 , type 3 , type 6 , cellular fibronectin , tenascin and laminin . ^^^ The newly synthesized collagen type 1 , type 3 , type 6 , cellular fibronectin , tenascin and laminin were deposited in the anterior corneal stroma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To investigate the mechanism by which MMPs mediate the survival of osteoblasts , we examined the effect of GM 6001 on MC3T3 E 1 osteoblasts in the presence of extracellular matrix components and growth factors , including tenascin , fibronectin , laminin , collagenase cleaved collagen , gelatin , parathyroid hormone , basic fibroblast growth factor , vascular epidermal growth factor , insulin like growth factor , interleukin 1 , and latent and active transforming growth factor beta ( TGF beta ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Furthermore , to evaluate the biological effects of GM CSF on SaOS 2 cells , we have investigated cell proliferation and differentiation of these cells treated with different doses of the growth factor through : ( 1 ) a morphological analysis of typical osteoblast differentiation markers such as osteopontin and BSP 2 ; ( 2 ) measurement of alkaline phosphatase ( ALP ) activity ; ( 3 ) production of bone ECM components ( collagen 1 , fibronectin , tenascin , and laminin ) ; ( 4 ) production of interleukin 6 ( IL 6 ) and osteocalcin in the culture medium . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
SBA labeling did not colocalize with collagen type 1 , 3 , 4 , 5 , and 6 , laminin , fibronectin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Although regarded initially as a fibronectin receptor , alpha ( 5 ) beta 6 may bind to arginine glycine aspartic acid sequences in other matrix molecules including tenascin and vitronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibroblastic cells and extracellular matrix components ( collagens 1 , 3 and 6 , fibronectin and tenascin ) comprised the stroma . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Gene expression of fibrogenetic cytokines and fibrotic proteins TGF beta ( 1 ) , PDGF beta , alpha ( 1 ) collagen type 4 , alpha ( 1 ) collagen type 1 , fibronectin , and tenascin was analyzed , by reverse transcription polymerase chain reaction ( RT PCR ) , 24 hr after transfection . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The study was performed by immunohistochemical analysis using antibodies against collagen types 1 , 3 , 4 , 5 , and 6 and the glycoproteins fibronectin , laminin , vitronectin and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical expression of extracellular matrix components tenascin , fibronectin , collagen type 4 and laminin in breast cancer : their prognostic value and role in tumour invasion and progression . ^^^ The immunohistochemical expression of the extracellular matrix ( ECM ) components tenascin ( TN ) , fibronectin ( FN ) , collagen type 4 ( Coll ) and laminin ( LN ) , and their possible relationships were studied in a series of 134 operable breast cancer cases . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
STUDY DESIGN : Twelve cases of OOC were submitted to a panel of antibodies composed of cytokeratins ( 10 , 13 , and 14 ) and extracellular matrix proteins : fibronectin , types 1 and 3 collagen , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In conclusion , the observed staining patterns clarify the cellular origin and indicate the possible biological function of tenascin , vitronectin , laminin , fibronectin and collagen type 4 in these highly invasive malignant tumors of glial origin . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A comparison was made of the intensity of immunofluorescence staining of chondroitin sulfate proteoglycan , fibronectin , tenascin and thrombospondin in the endoneurial ECM of rat dorsal and ventral spinal roots . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Senescent HSCs expressed reduced levels of extracellular matrix proteins , including collagens , tenascin , and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We used enzyme linked immunosorbent assay and reverse transcriptase polymerase chain reaction to assess the production of the following proteins : matrix metalloproteinase ( MMP ) 3 , MMP 9 , tissue inhibitor of MMP 1 , transforming growth factor beta 1 , thrombospondin 1 , tenascin , and fibronectin . ^^^ In the absence of injury , tenascin , fibronectin , MMP 3 , and tissue inhibitor of MMP 1 are actively expressed . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunolocalization of collagen 4 , laminin , fibronectin , tenascin , and collagen 6 was performed on cryosections . ^^^ The comparison of TPN and EN patients revealed differences in the distribution patterns of the ECM proteins laminin , fibronectin , and tenascin along the crypt villus axis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Effect of tenascin and fibronectin on the migration of human corneal fibroblasts . ^^^ PURPOSE : To investigate the effect of fibronectin and tenascin on the migration of corneal fibroblasts . ^^^ The migration on collagen 1 , fibronectin , and tenascin with and without transforming growth factor ( TGF ) alpha / fibroblast growth factor ( FGF ) 2 stimulation and the effect of soluble tenascin and fibronectin on corneal fibroblast migration on collagen 1 coated wells were investigated . ^^^ CONCLUSION : Fibronectin and tenascin influenced corneal fibroblast migration and adhesion , respectively , and may play a role in stromal cell movement during wound healing . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and fibronectin in nasal polyps . ^^^ To explore the role of tenascin ( TN ) and fibronectin ( FN ) in the pathophysiology of nasal polyps ( NP ) , the expression of TN and FN in NP from 34 patients and inferior turbinates from 20 patients with deviation of nasal septum was immunohistochemically studied . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : The ECM components , laminin ( LN ) , type 4 collagen , fibronectin ( FN ) , and tenascin ( TN ) were revealed using a streptoavidin biotin immunohistochemical technique and analyzed in 34 cases of salivary gland tumors : pleomorphic adenoma ( PA ) ; myoepithelioma ; basal cell adenoma ( BCA ) ; polymorphous low grade adenocarcinoma ( PLGA ) ; and adenoid cystic carcinoma ( ACC ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of tenascin and fibronectin in nasal polyps ] . ^^^ OBJECTIVE : To explore the role of tenascin ( TN ) and fibronectin ( FN ) in the pathophysiology of nasal polyp . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This suggests that in order to achieve optimal neurite regrowth in the injured adult CNS , therapeutic strategies must include approaches that increase the number of integrins and other key receptors in damaged central neurons , as well as provide the appropriate growth promoting peptides in a `` regeneration cocktail . ' ' In this review , we describe the ability of peptides derived from tenascin C , fibronectin , and laminin 1 to influence neuronal growth . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : The ' snowbank ' was examined using immunohistochemical techniques and a panel of monoclonal and polyclonal antibodies directed against glial fibrillary acidic protein ( GFAP ) , cytokeratin , alpha smooth muscle actin , tenascin , laminin , fibronectin , and collagen types 1 , 2 , and 3 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin N , a novel member of the tenascin family , was identified and shown to encode characteristic structural motifs of a cysteine rich stretch , 3 . 5 epidermal growth factor like repeats , 12 fibronectin type 3 homologous domains , and a fibrinogen like domain . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of fibronectin , collagen type 4 , tenascin and the integrin subunits ( alpha 2 , alpha 3 , alpha 4 , alpha 5 and beta 1 ) was studied by immunohistochemistry . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Overproduction of fibronectin and tenascin by HMCs was normalized by tunicamycin and brefeldin A . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Production of fibronectin and tenascin isoforms and their role in the adhesion of human immortalized corneal epithelial cells . ^^^ PURPOSE : To study the production and deposition of fibronectin ( Fn ) isoforms and tenascin C ( Tn C ) by immortalized human corneal epithelial ( HCE ) cells and their integrin dependent adhesion characteristics . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
PURPOSE : To study the expression of the extracellular matrix ( ECM ) proteins , tenascin , laminin , and fibronectin in the conjunctiva of patients with active vernal keratoconjunctivitis ( VKC ) . ^^^ The presence and distribution of tenascin , laminin , and fibronectin were assessed microscopically with immunohistochemical techniques and a panel of monoclonal and polyclonal antibodies directed against tenascin , laminin , and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This study examined the relationship among the secretion of extracellular matrix proteins fibrillin , fibronectin , tenascin , and vascular smooth muscle cell ( VSMC ) apoptosis . ^^^ Immunohistochemical study of cultured MS and BAV VSMC showed intracellular accumulation and reduction of extracellular distribution of fibrillin , fibronectin , and tenascin . ^^^ Western blot showed no increase in expression of fibrillin , fibronectin , or tenascin in MS or BAV VSMC and increased expression of MMP 2 in MS VSMCs . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : Using immunohistochemical methods , the distribution of the extracellular matrix proteins , fibronectin , tenascin , and bone sialoprotein ( BSP ) , as well as the integrin subunits alpha 5 and beta 1 were studied in rats aged 3 , 5 and 8 weeks . ^^^ Tenascin expression was less marked compared with fibronectin , but was more distinctly associated with cells and peri cellular areas of the epithelial connective tissue interface , the gingiva and within the periodontal ligament . ^^^ A notable finding was the increased staining intensity of fibronectin , tenascin and alpha5beta1 integrin in all 5 week old molar sections in the periodontal ligament matrix and cells , apical to the cemento enamel junction ( CEJ ) along the alveolar crest ( AC ) ridge height . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cells were plated on poly l lysine or fibronectin and treated with tenascin , Hep 1 , or SPARC peptides to inhibit focal adhesion formation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies against myocilin and other ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , hyaluronic acid , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of fibronectin and tenascin as a demonstration of vital reaction in rat skin and muscle . ^^^ We analyzed the expression of fibronectin ( FN ) and tenascin ( TN ) in wounds inflicted in abdominal skin of 12 adult rats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
BATs populated with avian flexor tendon cells expressed collagen genes 1 , 3 , and 12 as well as aggrecan , fibronectin , prolyl hydroxylase , and tenascin , consistent with expression levels of cells grown on collagen bonded two dimensional surfaces or in native , whole , avian flexor tendon . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We used immunohistochemistry to determine if several potential ligands ( fibronectin , tenascin , vitronectin , and osteopontin ) were expressed during neuronal migration along radial glia ( RG ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Here we identify tenascin C as a ligand for the lectins of all these proteoglycans and map the binding site on the tenascin molecule to fibronectin type 3 repeats , which corresponds to the proteoglycan lectin binding site on tenascin R . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The side chain dynamics of methyl groups in two structurally related proteins from the fibronectin type 3 ( fnIII ) superfamily , the third fnIII domain from human tenascin ( TNfn 3 ) and the tenth fnIII domain from human fibronectin ( FNfn 10 ) , have been studied by NMR spectroscopy . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By multiple fluorescence labeling , we found that the intracellular smooth muscle alpha actin ( SMA ) fibers and the two extracellular adhesive matrix proteins tenascin and fibronectin vary in their presence in stromal and / or myeloid cells according to the degree of bone marrow fibrosis in chronic myeloproliferative disorders ( CMPDs ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Vascular cuffs , which form in the base and margins of leg ulcers , have been reported to contain fibrin , laminin , fibronectin , tenascin , and types 1 and 3 collagen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Localization of a cryptic binding site for tenascin on fibronectin . ^^^ Fibronectin and tenascin are large extracellular matrix proteins that interact with each other and with integrin receptors to regulate cell growth and movement . ^^^ Fibronectin is a covalent dimer and tenascin is a hexamer . ^^^ The site on tenascin to which fibronectin binds has been localized to type 3 modules 3 5 . ^^^ In this study we use surface plasmon resonance to examine the interaction between various fragments of fibronectin and tenascin to further characterize and localize the binding sites . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin and fibronectin expression in odontogenic cysts . ^^^ METHODS : Thirty OCs were selected : 10 radicular cysts ( RCs ) , 10 dentigerous cysts ( DCs ) , 10 non syndrome odontogenic keratocysts ( OKCs ) and they were immunohistochemically analyzed to verify the expression pattern of tenascin and fibronectin . ^^^ The higher tenascin and fibronectin expression in the capsule of OKCs suggests marked instability in the cystic structure and may contribute to its aggressive behavior . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The gene expression from ML to pellet at day 7 included an increase in cartilage matrix proteins like collagen type 11 , tenascin C , dermatopontin , COMP and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Massive deposition of fibronectin and tenascin was observed adjacent to the implant surface . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This fiber system was distinct from that of major collagens , fibronectin , or tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The interaction of tenascin C with fibronectin modulates the migration and specific metalloprotease activity in human mesothelioma cell lines of different histotype . ^^^ Tenascin C ( TN C ) with fibronectin ( FN ) are associated extracellular matrix ( ECM ) molecules frequently neo expressed in stromal remodeling during neoplastic progression , mostly at the invasive edge of these tumors . ^^^ Tenascin C alone or in association with other ECM molecules , could play an important role in the process of tumor invasion , acting as substrate for movement or modulating the migration on FN or promoting the degradation of ECM . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In 21 astrocytic neoplasms , the ECM composition was investigated in situ by the immunohistochemical detection of ECM glycoproteins ( tenascin , laminin , vitronectin , fibronectin , collagen types 1 6 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
No highly fluorescent layer of tenascin or fibronectin was found surrounding the implant area . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibrous wound repair associated with biodegradable poly L / D lactide copolymer implants : study of the expression of tenascin and cellular fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The connective tissue samples were examined immunohistochemically in order to study the occurrences of two extracellular matrix glycoproteins , tenascin and fibronectin . ^^^ Tenascin and fibronectin were present in samples from 1 week up to 4 weeks . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Collagen 4 expression was increased in sinusoidal endothelium and portal tracts of fulminant hepatic failure explants , whereas there were minimal changes in the expression of fibronectin , tenascin , and laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The ECM composition of fibronectin , tenascin , laminin , clusterin , and MMPs was found to vary dramatically with reproductive state . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Here we compare the properties of the transition states for folding of TI I 27 , the 27th immunoglobulin domain from human cardiac titin , and that of TNfn 3 , the third fibronectin type 3 domain from human tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin ( TN ) , fibronectin ( FN ) , type 1 ( col 1 ) and 3 collagen ( col 3 ) and osteonectin ( ONEC ) were detected by immunofluorescence . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunoexpression of the extracellular matrix ( ECM ) proteins laminin , fibronectin , tenascin and types 1 , 3 and 4 collagen was analyzed in the major and minor salivary glands of seven human fetuses at different gestational ages . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
OBJECTIVE : Investigate the immunohistochemical distribution of fibronectin , tenascin , laminin and collagen 4 in syndrome ( SOKC ) and non syndrome odontogenic keratocysts ( NSOKC ) . ^^^ RESULTS : Differences could be detected regarding tenascin , fibronectin and collagen 4 between the SOKC and NSOKC . ^^^ CONCLUSIONS : These findings show differences between the immunohistochemical expression of tenascin , fibronectin and collagen 4 which might indicate a more aggressive biological behavior of SOKC as compared with NSOKC . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
There was no correlation between expression of alphavbeta 6 and its ligands tenascin and fibronectin in pancreatic and gastric carcinomas . ^^^ CONCLUSIONS : Our findings indicate that : ( 1 ) alphavbeta 6 is overexpressed in pancreatic adenocarcinomas ; ( 2 ) alphavbeta 6 positive carcinomas originate from alphavbeta 6 expressing tissues ; ( 3 ) alphavbeta 6 expression in tumours seems to be regulated independently from that of its ligands tenascin and fibronectin ; and ( 4 ) in vitro overexpression of alphavbeta 6 in pancreatic carcinoma cell lines accompanies spheroid formation . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cell labeling with 3H glucosamine and immunoblot analysis were conducted to study SAD effects on the synthesis of glycosaminogycans ( GAG ) and the expression of fibronectin and tenascin , respectively . ^^^ Synthesis of extra cellular matrix components ( GAGs , fibronectin or tenascin ) by HEPM cells , however , was not inhibited by SAD . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
ECM components such as Collagen 1 ( CoI ) , Fibronectin ( FN ) , Vitronectin ( VN ) and Tenascin ( TN ) were secreted and organized only on the SB and TPS surfaces while they remained into the cytoplasm on the S surfaces . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We present data for a construct of eight fibronectin type 3 domains from the human form of tenascin that exhibits approximately 1 kcal mol ( 1 ) increase in stability compared to the monomer . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Whereas the fibroblasts in the scaffold initially secreted a typical provisional regenerative matrix ( fibronectin , tenascin ) , with time collagens of mature dermis ( type 1 and 3 ) were accumulating giving rise to an in vivo like matrix with regularly organised bundles of striated collagen fibrils . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : Many pathophysiological factors may be involved in the occurrence of adenomyosis : immunological factors , estrogen sulfatase activity , tenascin which is a fibronectin inhibitor and angiogenesis and growth factors such as EGF , VEGF and GM CSF . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Paraffin embedded brain sections were immunostained for glial fibrillary acidic protein ( GFAP ) and vimentin ( VN ) to identify glial cells ; for microtubule associated protein 2 ( MAP 2 ) and neuronal nuclear protein ( NeuN ) to document neurons ; for neurofilament ( NF ) to identify axons ; and for chondroitin sulfate ( CS ) , tenascin ( TN ) , and fibronectin ( FN ) to show the ECM . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
OBJECTIVE : To measure the immunohistochemical expression of the extracellular matrix ( ECM ) components tenascin , fibronectin , collagen type 4 and laminin in urothelial carcinomas , and to correlate their expression with clinicopathological features to clarify the prognostic value of these molecules and their role in tumour progression . ^^^ The expression of tenascin , fibronectin , collagen type 4 and laminin was correlated with clinicopathological features ( tumour grade and stage , multiplicity , simultaneous in situ component , the proliferative activity as estimated by the two proliferation associated indices , Ki 67 and proliferating cell nuclear antigen , the recurrence rate , and the progression of invading tumour ) . ^^^ Stromal tenascin expression was positively correlated with proliferative activity , and with the expression of fibronectin and collagen type 4 . ^^^ The expression of tenascin , fibronectin and collagen type 4 seems to be correlated with more aggressive tumour behaviour . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the review , the role of integrin receptors as well as of some of their ligands of the extracellular matrix in cases of parotid neoplasms is discussed , in particular , the data concerning the expression of various types of integrin adhesion molecules in benign and malignant tumors of the parotid , the expression of fibronectin , tenascin , and collagen type 4 etc . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Numerous in vitro and in vivo studies indicate that this TGFbeta induced EMT is part of a wound healing response in lens epithelial cells and is characterized by induced expression of numerous extracellular matrix proteins ( laminin , collagens 1 , 3 , tenascin , fibronectin , proteoglycans ) , intermediate filaments ( desmin , alpha smooth muscle actin ) and various integrins ( alpha 2 , alpha 5 , alpha7B ) , as well as the loss of epithelial genes [ Pax 6 , Cx 43 , CP 49 , alpha crystallin , E cadherin , zonula occludens 1 protein ( ZO 1 ) ] . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the present study , the authors investigated the expression of various extracellular matrix components and in particular tenascin , fibronectin , laminin , collagen 4 , and MMP 3 glycoprotein as well as the expression of glial fibrillary acidic protein in each type of epithelial membrane in order to elucidate the role of these molecules in the formation of these two types of membranes . ^^^ Tenascin and fibronectin were observed as major components in the extracellular matrix , while laminin and collagen type 4 were detected as minor components in both types of membranes . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Protein engineering Phi value analysis combined with single molecule atomic force microscopy ( AFM ) was used to probe the molecular basis for the mechanical stability of TNfn 3 , the third fibronectin type 3 domain from human tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In cases of laryngeal cancer , disorganization of the basal membrane components ( laminins 1 and 5 , type 4 collagen , tenascin , fibronectin isoforms ) which represent integrins ligands , is found . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The integrin alphavbeta 6 , a receptor for fibronectin , vitronectin , tenascin and TGF beta latency associated peptide ( LAP ) , is not detectable on normal oral epithelium but is neo expressed in oral squamous cell carcinomas ( OSCC ) and epithelial dysplasia . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : In the early stage of OSF , tenascin , perlecan , fibronectin , collagen type 3 were characteristically enhanced in the lamina propria and the submucosal layer . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunofluorescence was used to determine GM CSFR expression and to investigate the deposition of ECM ( type 1 collagen , fibronectin , and tenascin ) . ^^^ RESULTS : Deposition of ECM by normal fibroblasts appeared not to be influenced by stimulation with GM CSF ; in contrast , after stimulation with GM CSF SSc fibroblasts showed increased deposition of fibronectin and tenascin , while type 1 collagen production was decreased ; these results were found with both immunofluorescence and ELISA . ^^^ CONCLUSION : These results suggest that in SSc fibroblasts GM CSF exerts a blocking effect on the deposition of type 1 collagen , through an inhibitory action on mRNA , while the production of other components of ECM such as fibronectin and tenascin is increased by stimulation with this cytokine . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of the extracellular matrix related genes , such as fibronectin , laminin and tenascin C , and apoptosis related genes , such as bax , bcl 2 and survivin , was evaluated by reverse transcription polymerase chain reaction ( RT PCR ) and by immunohistochemistry in normal breast tissue and benign and malignant breast tumors and then correlated to several clinical parameters : estrogen and progesterone receptors , Ki 67 , ErbB 2 , tumor size , lymph node status and grading . ^^^ After RNA extraction , an RT PCR was performed to detect fibronectin , laminin , tenascin C , bax , bcl 2 and survivin gene expression . ^^^ Thirty two samples were evaluated also by immunohistochemistry at the protein level to detect fibronectin , laminin , tenascin C , bax and survivin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We focused our attention on BL composition and organization and studied some of the main components of the Extracellular Matrix such as Tenascin , Laminins , Fibronectin , type 1 , 3 and 4 Collagens . ^^^ Collagen 1 , Laminin alpha 2 chain and Fibronectin amounts decreased in pathological samples , while type 4 Collagen and Tenascin synthesis increased . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The alphavbeta 6 integrin is epithelial specific and binds to the ECM proteins fibronectin , vitronectin and tenascin , and also to the latency associated peptide of TGF beta . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
At immunohistochemistry , proteins whose overproduction has been demonstrated in response to abnormal wall stress , such as tenascin and fibronectin , were more expressed in the convexity than in the concavity , especially in the stenosis subgroup . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical assessment of fibronectin and tenascin and their integrin receptors alpha5beta1 and alpha9beta1 in gastric and colorectal cancers with lymph node and liver metastases . ^^^ The aim of the current study was to assess immunohistochemically and compare the level of expression of tenascin ( TN ) and fibronectin ( FN ) and their integrin receptors alpha9beta1 and alpha5beta1 in the primary colorectal and gastric tumors , and in corresponding lymph node and liver metastases from 53 patients . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Western blot , RT PCR and immunohistochemistry disclosed an asymmetric pattern in the expression of some ECM proteins ( laminin , tenascin , fibronectin ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In immunohistochemical studies , no highly fluorescent layer of tenascin or fibronectin was found adjacent to the implant . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Quantitative comparative RT / PCR and real time PCR were used to evaluate the expression of collagen 3 and 4 , fibronectin , tenascin , MMP 2 , CTGF , E cadherin and cadherin 11 genes , as well as those of the Smad signalling pathway . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This expression was also positively correlated with microvessel density , VEGF expression and extracellular matrix components tenascin and fibronectin . ^^^ In addition , the correlation of stromal TSP 1 expression with extracellular matrix components fibronectin and tenascin indicate its possible implication in tumour stroma remodeling . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We used the AFM to repeatedly stretch and relax a recombinant tenascin fragment TNfnALL to allow the fibronectin type 3 ( FnIII ) domains to undergo repeated unfolding / refolding cycles . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
OBJECTIVE : This study investigated the biomodulatory effect of the gallium aluminum arsenate laser ( GaAlAs ) in pulp cells on reactional dentinogenesis , and on the expression of collagen type 3 ( Col 3 ) , tenascin ( TN ) , and fibronectin ( FN ) in irradiated dental tissues and controls ( not irradiated ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Multiple sequence alignment reveals that differences in the size of tenascin W from various vertebrate classes can be explained by duplications of specific fibronectin type 3 domains . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We show that incubation of the human bronchial epithelial cell line , BEAS 2B , or primary cultured human bronchial epithelial cells , normal human bronchial epithelial cells , with subcytotoxic concentrations ( 0 . 1 , 0 . 3 , and 1 microM ) of major basic protein ( MBP ) , or eosinophil peroxidase ( EPO ) , augmented the transcripts of endothelin 1 , TGF alpha , TGF beta 1 , platelet derived growth factor ( PDGF ) beta , epidermal growth factor receptor , metalloproteinase ( MMP ) 9 , fibronectin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemical expression of fibronectin and tenascin after direct pulp capping with calcium hydroxide . ^^^ The aim of this study was to investigate the expression of 2 extracellullar matrix glycoproteins , fibronectin ( FNC ) and tenascin ( TNC ) , following direct pulp capping with calcium hydroxide ( CH ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Furthermore , OA 5D5 treatment decreased tumor cell density > 2 fold , with a consequent increase in ECM deposition and increased immunoreactivity for laminin , fibronectin , and tenascin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Binding of tenascin C to soluble fibronectin and matrix fibrils . ^^^ The small splice variant of tenascin C ( TN ) has eight fibronectin type 3 ( FN 3 ) domains . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C ( TN C ) is a matrix molecule reported to bind some cell lines and to inhibit adhesion of some cell types to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin R ( J 1 160 / 180 inhibits fibronectin mediated cell adhesion functional relatedness to tenascin C . ^^^ Fibronectin mediated cell attachment and spreading can be affected in a negative way by tenascin C , an extracellular matrix glycoprotein expressed in a temporally and spacially restricted manner during early morphogenesis . ^^^ When offered as mixed substrata with other extracellular matrix molecules , the two tenascin R isoforms and tenascin C derived from mouse brain selectively inhibit fibronectin dependent cell adhesion and neurite outgrowth , and affect cell morphology of different mesenchymal and neural cells . ^^^ The expression of tenascin R and tenascin C in the nervous system at times and locations where fibronectin mediated cellular processes take place may be related to the role of inhibitory signals in the extracellular matrix in the regulation of cell migration and differentiation in general . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Two heparin binding regions have recently been localized per tenascin C monomer , one in the C terminal fibrinogen like domain and the other in fibronectin type 3 repeats 3 5 . ^^^ Whereas the complete protein and a mutant lacking fibronectin type 3 repeats 1 5 bound to heparin agarose , recombinant tenascin C missing the C terminal fibrinogen like globe did not . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the formed tumors the stroma was found to contain mesenchymal extracellular matrix proteins such as tenascin C , fibulins 1 and 2 and fibronectin , but no nidogen . ^^^ A downregulation of tenascin C mRNA and an upregulation of fibronectin mRNA expression by dexamethasone was noted . ^^^ Transforming growth factor beta 1 stimulated tenascin C synthesis but did not affect fibronectin or fibulin 2 synthesis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Proteins were chosen based on their presence in normal or neoplastic nervous tissue , and included the extra cellular matrix molecules fibronectin , collagens , fibrinogen , laminin , tenascin C , thrombospondin , and the neuron glia cell adhesion molecule , Ng CAM . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In contrast . fibronectin appears diminished in wounds of tenascin C deficient mice . ^^^ However , the lack of tenascin C together with the reduced amount of fibronectin has no influence on the quality of the healing process . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In vitro , tenascin C interferes with cell fibronectin interactions , and promotes the motility of many cell types including the neural crest . ^^^ Double label immunohistochemistry reveals that tenascin C is found in the mesenchyme adjacent to the ventral half of the dorsal aorta where the primordial germ cells penetrate the vessel wall , and both tenascin C and fibronectin are present in the extracellular matrix through which the primordial germ cells migrate to reach the genital ridges . ^^^ Unlike fibronectin , which is found throughout the splanchnic mesoderm , tenascin C is concentrated in the proximal part of the splanchnic region where the primordial germ cells are concentrated . ^^^ These experiments indicate that tenascin C is a component of the migratory environment for many motile cells in the early embryo , where it has the potential to mediate cell fibronectin interactions . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Growth on myelin associated glycoprotein ( MAG ) and neural cell adhesion molecule ( N CAM ) selectively increased the number of viable cells per culture 2 weeks after plating as much as tenfold and sixfold , respectively , over background survival on an albumin substrate , whereas L 1 , tenascin R , tenascin C , fibronectin , and laminin were ineffective . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C , proliferation and subendothelial fibronectin in progressive pulmonary vascular disease . ^^^ Previously , using cultured smooth muscle cells , we demonstrated that epidermal growth factor ( EGF ) dependent proliferation and migration are dependent on tenascin C ( Tn ) and cellular fibronectin ( Fn ) , respectively . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
C 6 glioma cells adhere to and spread on deletion variants of tenascin C containing only the epidermal growth factor like domains or the fibronectin type 3 repeats and the fibrinogen globe . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Effects of tenascin C in cultured hippocampal astrocytes : NCAM and fibronectin immunoreactivity changes . ^^^ In this report we show that the treatment of cultured hippocampal astrocytes with tenascin C results in an increased fibronectin and NCAM immunoreactivities . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Glycosaminoglycans modulate fibronectin matrix assembly and are essential for matrix incorporation of tenascin C . ^^^ We have investigated the role of glycosaminoglycans in fibronectin matrix assembly and the incorporation of tenascin C into matrix fibrils . ^^^ Chinese hamster ovary cell mutants with a total block in heparan and chondroitin sulfate production failed to assemble a fibronectin matrix , and incorporated no tenascin C . ^^^ Another mutant with reduced heparan sulfate produced a normal fibronectin matrix but failed to incorporate tenascin C . ^^^ Excess soluble glycosaminoglycans inhibited the binding of tenascin C to purified fibronectin in ELISA , and completely blocked incorporation into matrix fibrils . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Human tenascin C contains 8 consecutive type 3 fibronectin ( TNCfn ) domains that are involved in alternative splicing and potentially generate a large number of isoforms that code for tenascin C proteins with subtly different functions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The tenascin C mutants had either deletions of all EGF like repeats , all fibronectin type 3 repeats or of the fibrinogen globe . ^^^ When tenascin C was added to the medium of fibroblasts plated on fibronectin coated wells , cell adhesion was blocked by intact tenascin C , but not by mutants missing the fibrinogen globe . ^^^ The mutants missing the fibronectin type 3 repeats allowed more rapid neurite outgrowth than all other tenascin C variants and the mutant consisting essentially of oligomerized EGF like repeats was as active a substrate for neurite outgrowth as laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
For neural cell adhesion molecules , L 1 , fibronectin , tenascin C , integrins , and vascular cell adhesion molecules , the molecular structure of domains , and in most cases their binding sites , have been elucidated . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These perturbation experiments suggested that distinct tenascin C fibronectin type 3 repeats sustain the growth of thalamic and cortical axons on cortical membrane carpets , whereas the EGF type repeats are not involved . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have studied the adhesive and invasive properties of four human colorectal carcinoma cell lines ( Co 115 , HT 29 , SW 480 , SW 620 ) confronted in vitro with a human mesothelial cell monolayer or with the ECM proteins collagen 4 , laminin 1 , fibronectin , tenascin C and vitronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Around and beneath the epithelial plugs and along the keratotomy scars , deposits of types 3 , 6 , 8 , and 14 collagen ; fibrillin 1 ; fibronectin ; and tenascin C were found , together with short streaks of types 4 ( alpha 1 alpha 2 ) and 7 collagen , laminin 1 and 5 , entactin , and perlecan . alpha 3 alpha 4 Type 4 collagen chains were abnormally absent from the BM around the epithelial plugs . ^^^ At the edges of the keratomileusis flap , subepithelial fibrosis areas were found , with abnormal deposits of eight different collagen types , perlecan , fibronectin , fibrillin 1 , and tenascin C . ^^^ ECM alterations outside the scarred areas included the appearance of tenascin C in the stroma and of alpha 1 alpha 2 type 4 collagen in the epithelial BM , and the disappearance of fibronectin from Descemet ' s membrane . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
All forms of tenascin C have eight constant fibronectin type 3 repeats , but additional fibronectin type 3 repeats can be spliced into a variable domain found between the fifth and sixth constant repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A novel off resonance rotating frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type 3 domain of human tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of fibronectin and tenascin C mRNA by myofibroblasts , vascular cells and epithelial cells in human colon adenomas and carcinomas . ^^^ Twenty nine adenocarcinomas , 5 adenomas and non neoplastic mucosa samples were therefore investigated to determine their fibronectin ( FN ) and tenascin C ( TN C ) expression using in situ hybridization ( ISH ) and immunohistochemical staining . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The interaction was abolished by the addition of EDTA , or TNfn 4 , 5 , a bacterially expressed tenascin C fragment comprising the fourth and fifth fibronectin type 3 module . ^^^ We conclude that a divalent cation dependent interaction between the COOH terminal domain of neurocan and those fibronectin type 3 repeats is substantially involved in the binding of neurocan to tenascin C . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C transcripts are expressed in motile cells and at sites of tissue modeling during development , and alternative splicing generates variants that encode different numbers of fibronectin type 3 repeats . ^^^ We have examined the in vivo expression and cell adhesive properties of two full length recombinant tenascin C proteins : TN 190 , which contains the eight constant fibronectin type 3 repeats , and TN ADC , which contains the additional AD 2 , AD 1 , and C repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Differential expression of fibronectin , tenascin C and NCAMs in cultured hippocampal astrocytes activated by kainate , bacterial lipopolysaccharide or basic fibroblast growth factor . ^^^ In the present report we used Western blots and immunocytochemistry to investigate the expression of neural cell adhesion molecule ( NCAM ) , fibronectin and tenascin C in cultured astrocytes from rat hippocampus . ^^^ Treatment of astrocytes with kainic acid resulted in an increase of tenascin C , a decrease of fibronectin and a shift of NCAMs isoforms : NCAM 140 and PSA NCAM ( polysialic acid rich NCAMs ) were increased while NCAM 120 was decreased , bFGF increased fibronectin , tenascin C and NCAM 120 , while decreasing PSA NCAM . ^^^ Finally , the treatment of astrocytes with lipopolysaccharide induced a significant increase of fibronectin , tenascin C and NCAM 120 but did not modify the expression of NCAM 140 and PSA NCAM . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Identification of the ligand binding site for the integrin alpha 9 beta1 in the third fibronectin type 3 repeat of tenascin C . ^^^ The integrin alpha 9 subunit forms a single heterodimer , alpha 9 beta1 that mediates cell adhesion to a site within the third fibronectin type 3 repeat of tenascin C ( TNfn 3 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We found that three monoclonal antibodies against the carboxyterminal type 3 fibronectin repeats of tenascin C ( TNCfn 7 8 ) increased the number of the non adherent myeloid cells in myeloid long term bone marrow cultures . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have shown that a fibronectin ( FN ) matrix is required for the organization of tenascin C ( TN C ) matrices by peritumor fibroblasts ( PTF ) cultured from tissue surrounding oral squamous cell carcinoma ( SCC ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The purpose of this study was to use quantitative in situ hybridization to determine the relative abundance of transcripts encoding the alternatively spliced fibronectin type 3 repeats of tenascin C in the embryonic avian optic tectum . ^^^ RESULTS : Densitometric analysis revealed that more than half of the total tenascin C mRNAs expressed in the ventricular zone of the E 10 optic tectum encode the variable fibronectin type 3 repeats `` A , ' ' `` AD 1 ' ' and `` D . ' ' Transcripts encoding other variable repeats were detectable , but at considerably lower levels . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Both purified sodium channels and the extracellular domain of the beta 2 subunit bound specifically to fibronectin type 3 repeats 1 2 , A , B , and 6 8 of tenascin C and fibronectin type 3 repeats 1 2 and 6 8 of tenascin R but not to the epidermal growth factor like domain or the fibrinogen like domain of these molecules . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The study assessed immunohistochemically the location and distribution of various non collagenous matrix proteins ( fibronectin , laminin , tenascin C , osteocalcin , thrombospondin 1 , vitronectin and undulin ) in musculoskeletal tissues of rat . ^^^ However , it was co distributed with fibronectin and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C mRNA levels were also influenced , whereas relative amounts of fibronectin and matrix metalloproteinase 2 mRNA were barely affected . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C inhibits beta 1 integrin dependent T lymphocyte adhesion to fibronectin through the binding of its fnIII 1 5 repeats to fibronectin . ^^^ We have addressed the latter point by studying the effect of the matrix protein tenascin C ( TN C ) on T lymphocyte adhesion to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have investigated the impact of cellular environment on the neurite outgrowth promoting properties of the alternatively spliced fibronectin type 3 region ( fnA D ) of tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This enhanced growth was abolished by co incubation with a function blocking antiserum to beta 1 integrin receptors , whilst immunoreactivity for some beta 1 integrin ligands ( tenascin C and fibronectin ) increased at the DREZ by 21 dpl , suggesting that beta 1 integrin ligands may stimulate the growth of embryonic neurites across the 21 dpl DREZ . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Mechanical strain induced tenascin C mRNA ( 3 . 9 + / 0 . 5 fold , p < 0 . 01 , n = 13 ) and tenascin C protein in an amplitude dependent manner but did not induce secreted protein acidic and rich in cysteine nor fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Expression of laminin alpha 1 , alpha 2 , alpha 4 , and alpha 5 chains , fibronectin , and tenascin C in skeletal muscle of dystrophic 129ReJ dy / dy mice . ^^^ In addition , expression patterns of laminin alpha 1 , alpha 2 , alpha 4 , and alpha 5 chains , the interstitial proteins fibronectin and tenascin C , and the adhesion molecules VCAM 1 , ICAM 1 , and alpha 4 integrin were characterized in skeletal muscle of 1 and 7 day and mature ( > 6 weeks old ) dy / dy and control 129ReJ mice . ^^^ Focal lesions were observed in mature skeletal muscle only , characterized by necrotic tissue , isolated VCAM 1 and ICAM 1 positive cells indicative of inflammatory processes , and regenerating muscle fibers surrounded by intense tenascin C and fibronectin expression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C inhibits beta 1 integrin dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside mediated signaling mechanism . ^^^ We have previously shown that the extracellular matrix molecule tenascin C inhibits fibronectin mediated cell adhesion and neurite outgrowth by an interaction with a cellular RGD independent receptor which interferes with the adhesion and neurite outgrowth promoting activities of the fibronectin receptor ( s ) . ^^^ First , in substratum mixtures with fibronectin , an RGD sequence containing fragment of the molecule or synthetic peptide , tenascin C inhibited cell adhesion and spreading by a disialoganglioside dependent , sialidase sensitive mechanism leading to an inhibition of protein kinase C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Spatiotemporal changes of fibronectin , tenascin C , fibulin 1 , and fibulin 2 in the skin during the development of chronic contact dermatitis . ^^^ Subsequently , the spatiotemporal changes of fibronectin , tenascin C , fibulin 1 , and fibulin 2 in the skin were examined . ^^^ In the acute phase of inflammation ( day 3 day 12 ) , the amount of fibronectin and tenascin C increased markedly and were degraded , whereas the amount of fibulin 2 changed slightly . ^^^ In contrast , the amounts of fibronectin and tenascin C decreased and their degradation was suppressed in the chronic phase ( day 15 day 66 ) , but the amount of fibulin 2 increased . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Function blocking antibodies to EMMPRIN significantly inhibited oral SCC cell migration on tenascin C ( TN C ) and fibronectin as well as invasion through a reconstituted basement membrane ( RBM ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The amount of pro TRH per dish , quantified by Western blotting , was increased to 275 % for laminin , 191 % for fibronectin and 173 % for tenascin C ( control=100 % ) ; there was no effect of vitronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Involvement of chondroitin sulfates on brain derived tenascin R in carbohydrate dependent interactions with fibronectin and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The catalytic domain of MMP 19 was able to hydrolyze the basement membrane components type 4 collagen , laminin , and nidogen , as well as the large tenascin C isoform , fibronectin , and type 1 gelatin in vitro , suggesting that MMP 19 is a potent proteinase capable of hydrolyzing a broad range of extracellular matrix components . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using immunofluorescent staining and confocal microscopy we found that IGFBP 3 accumulates with increasing age in the chondrocyte territorial matrix where it co localizes with fibronectin , but not with tenascin C or type 6 collagen . ^^^ Using purified proteins we demonstrated that IGFBP 3 binds to fibronectin in a dose dependent manner , but not to tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The Wnt 7a transduced cultures showed characteristics of a less mature culture with persistent expression of NCAM , N cadherin , wider distribution of integrin beta 1 and fibronectin , and suppression of tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
After skin injury , a significant enhancement of granulation tissue formation was detected in the activin overexpressing mice , possibly as a result of premature induction of fibronectin and tenascin C expression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In both skin and corneal wounds , fibronectin expression is abnormally low in tenascin C knockout mice . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We found that IGFBP 3 accumulated around chondrocytes in the pericellular / territorial matrix , where it co localized with fibronectin , but not with the other matrix proteins tenascin C and type 6 collagen . ^^^ Binding studies using purified proteins demonstrated that IGFBP 3 does in fact bind to fibronectin , but not to tenascin C or type 6 collagen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To enable detection of tenascin C transcripts that are expressed at very low levels , we amplified by polymerase chain reaction the fibronectin type 3 repeats whose expression is regulated by alternative splicing . ^^^ In cDNA of cultured keratinocytes and fibroblasts , and in skin biopsies , several tenascin C transcripts could be detected that corresponded to tenascin C variants including different numbers of fibronectin type 3 repeats . ^^^ No differences were observed in reactivity between an antibody that binds all tenascin C isoforms and antibodies that bind fibronectin type 3 repeats that can be spliced out from smaller tenascin C isoforms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
As for the ligands of alpha 5 beta 6 , fibronectin and tenascin C have been identified . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Moreover , purified tenascin C inhibited the attachment of cultured tendon cells to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have found that the region of tenascin C containing only alternately spliced fibronectin type 3 repeat D , called fnD , when used by itself , dramatically increases neurite outgrowth in culture . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C splice variant adhesive / anti adhesive effects on chondrosarcoma cell attachment to fibronectin . ^^^ Fibronectin is a prominent adhesive molecule of the extracellular matrix that is often co localized with tenascin C in these processes . ^^^ We studied the chondrosarcoma cell line JJ 012 with enzyme linked immunoabsorbance assays , cell attachment assays and antibody blocking assays to determine the adhesive / anti adhesive properties of the two major tenascin C splice variants with respect to fibronectin and their effect on chondrosarcoma cell attachment . ^^^ We found that the small tenascin C splice variant ( 220 kDa ) binds to fibronectin , whereas the large tenascin C splice variant ( 320 kDa ) does not . ^^^ In addition , the small tenascin C splice variant was found to decrease adhesion for cells when bound to fibronectin , but contributed to adhesion when bound to plastic in fibronectin coated wells . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The effects of LIF in vivo on the amount and localisation of the ECM molecules , fibronectin , tenascin C , collagen type 4 and laminin were assessed by immunohistochemistry on regenerating skeletal muscle but no influence of LIF on ECM composition was observed . ^^^ Quantitation of the ECM produced by cultures ( enzyme linked immunosorbent assay ) showed that LIF affected the amount of fibronectin , tenascin C , collagen type 4 and laminin produced by fusing myoblasts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Interference of tenascin C with syndecan 4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation . ^^^ To investigate the effect of tenascin C on tumor cells , we analyzed its antiadhesive nature and effect on tumor cell proliferation in a fibronectin context . ^^^ Glioblastoma and breast carcinoma cell adhesion was compromised by a mixed fibronectin / tenascin C substratum , which concomitantly caused increased tumor cell proliferation . ^^^ We identified the antiadhesive mechanism as a specific interference of tenascin C with cell binding to the HepII / syndecan 4 site in fibronectin through direct binding of tenascin C to the 13th fibronectin type 3 repeat ( FNIII 13 ) . ^^^ Thus we describe a novel mechanism by which tenascin C impairs the adhesive function of fibronectin through binding to FNIII 13 , thereby inhibiting the coreceptor function of syndecan 4 in fibronectin induced integrin signaling . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Mouse tenascin C contains six alternatively spliced domains ( A 1 , A 2 , A 4 , B , C , and D ) between the fifth and the sixth type 3 fibronectin domains , which generate large numbers of TNC isoforms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Reverse transcription linked PCR analysis of hypothalamic mRNA revealed an FGF 1 induced expression not of the shortest isoform of tenascin C , but of the long isoforms ( with additional fibronectin type 3 domain insertions ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Chondroitin sulfate proteoglycan , fibronectin , tenascin C , and thrombospondin are common components of the endoneurial ECM involved in the normal function as well as regeneration of the peripheral nerve . ^^^ The present paper demonstrates a comparison of immunofluorescence staining for chondroitin sulfate proteoglycan , fibronectin , tenascin C , and thrombospondin in the endoneurium of the rat dorsal and ventral spinal roots . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The production of basement membrane molecules such as collagen type 4 and several laminins , the interstitial molecules fibronectin and tenascin C , and the cell surface molecules integrin alpha 5 and alpha 6 were quantitated in vitro using ELISA on cultured cells from MyoD ( / ) and wild type mice . ^^^ Differences were observed in the production of fibronectin , tenascin C , collagen type 4 , laminin 1 and integrin alpha 5 between control and MyoD ( / ) myotubes in vitro . ^^^ These results suggest that the delay in myotube formation in MyoD ( / ) muscle is not a direct result of altered expression of the matrix molecules collagen type 4 , laminins , fibronectin , tenascin C , and integrins alpha 5 , alpha 6 or alpha7 . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Activated rMMP 20 did not degrade type 1 or type 2 collagen , but efficiently hydrolyzed fibronectin , type 4 collagen , laminin 1 and 5 , tenascin C , and beta casein . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A recombinant protein encompassing the alternatively spliced fibronectin type 3 domains of tenascin C ( TnFnIII A D ) vigorously inhibited both early and late lymphocyte activation events including activation induced TCR / CD8 down modulation , cytokine production , and DNA synthesis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using a synthetic model of the provisional matrix , we have found that tenascin C regulates cell responses to a fibrin FN matrix through modulation of focal adhesion kinase ( FAK ) and RhoA activation . ^^^ The effects of tenascin C combined with its location around the wound bed suggest that this protein regulates fundamental processes of tissue repair by limiting the extent of matrix deposition and contraction to fibrin FN rich matrix in the primary wound area . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Confocal microscopy at 8 days post injury revealed heightened immunoreactivity for phosphacan , NG 2 , and tenascin C , particularly within fibronectin ( + ) scar tissue at lesion centers . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We searched by a cDNA subtraction screen for differentially expressed transcripts in MCF 7 mammary carcinoma cells grown on tenascin C versus fibronectin . ^^^ On tenascin C , cells had irregular shapes with many processes , whereas on fibronectin they were flat with a cobble stone like appearance . ^^^ The morphology of these cells on tenascin C was flat , resembling that of cells on fibronectin . ^^^ After transient transfection of HT 1080 fibrosarcoma and T98G glioblastoma cells with 14 3 3 tau , only the 14 3 3 tau expressing cells were able to adhere and survive on tenascin C , whereas all cells adhered well on fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
DESIGN : Semi quantitative immunohistological measures of co localization were used to compare the spatial distribution of IGFBP 3 , 4 , and 5 with the distributions of three peri cellularly enriched matrix molecules fibronectin , tenascin C , and type 6 collagen in osteoarthritic and non osteoarthritic human articular cartilage . ^^^ RESULTS : IGFBP 3 associated with fibronectin in the pericellular / territorial matrix ( approximately 40 % co localization ) but not with tenascin C , or type 6 collagen ( approximately 6 % and approximately 15 % co localization respectively , P < 0 . 05 ) . ^^^ In agarose diffusion assays IGFBP 3 interacted with fibronectin and heparan sulfate proteoglycan but not with type 6 collagen or tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type 3 BD domains via activation of the cell adhesion molecule F3 / contactin . ^^^ Tenascin C is a multimodular glycoprotein that possesses neurite outgrowth stimulating properties , and one functional site has been localized to the alternatively spliced fibronectin type 3 domain D . ^^^ Biochemical studies using F3 / contactin IgFc chimeric proteins confirmed that the adhesion molecule selectively reacts with the combination BD but not with other pairs of fibronectin type 3 repeats of tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fibronectin domains of extracellular matrix molecule tenascin C modulate hippocampal learning and synaptic plasticity . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In good agreement , rCTGF treatment of micromass cultures stimulated both expression of condensation associated macromolecules ( fibronectin and tenascin C ) and chondrocyte differentiation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Coregulation of fibronectin signaling and matrix contraction by tenascin C and syndecan 4 . ^^^ Tenascin C is an extracellular matrix protein that regulates cell response to fibronectin within the provisional matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Adhesion of T98G glioblastoma cells to a fibronectin substratum is inhibited by tenascin C . ^^^ Upon overexpression of tropomyosin 1 , cell spreading on a fibronectin / tenascin C substratum was restored , indicating that tenascin C destabilizes actin stress fibers through down regulation of tropomyosin 1 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The hypothesis was tested that mechanical loading , induced by hindlimb suspension and subsequent reloading , affects expression of the basement membrane components tenascin C and fibronectin in the belly portion of rat soleus muscle . ^^^ One day of reloading , but not the previous 14 days of hindlimb suspension , led to ectopic accumulation of tenascin C and an increase of fibronectin in the endomysium of a proportion ( 8 and 15 % ) of muscle fibers . ^^^ Large increases of tenascin C ( 40 fold ) and fibronectin ( 7 fold ) mRNA within 1 day of reloading indicates the involvement of pretranslational mechanisms in tenascin C and fibronectin accumulation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This stroma is produced to a large extent by myofibroblasts and contains various amounts of collagens ( type 1 , 3 , and 5 ) , chondroitin sulfate proteoglycan , hyaluronic acid , fibronectin , and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Tenascin C blocks cell cycle progression of anchorage dependent fibroblasts on fibronectin through inhibition of syndecan 4 . ^^^ To analyse the effect of tenascin C on fibronectin mediated adhesion , cells were plated on a mixed fibronectin / tenascin C substratum . ^^^ Interestingly , overexpression of the transmembrane proteoglycan syndecan 4 restored cell spreading , adhesion signaling and DNA replication on the fibronectin / tenascin C substratum . ^^^ This indicates that tenascin C causes cell cycle arrest and cdk 2 inactivation by interfering with fibronectin syndecan 4 interactions . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Therefore , we have performed an in vitro investigation of the role of collagen types 1 , 3 , and 5 , fibronectin , and two variants of tenascin C on adhesion and migration of the colorectal carcinoma cell line HRT 18 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Astrocytes express growth promoting molecules , including N Cadherin , laminin , fibronectin , and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The region of tenascin C containing only alternately spliced fibronectin type 3 repeat D ( fnD ) increases neurite outgrowth by itself and also as part of tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We found in human cumulus oocyte complexes the presence of specialized cells still capable of producing fibronectin and tenascin c in the post ovulatory period . ^^^ Moreover , fibronectin and tenascin c are present within the hyaluronan matrix at fertilization during the tubal sojourn of the ovum and the embryo . ^^^ Since pentraxin 3 is important in matrix stabilization and gamete interactions , a possible role for fibronectin and tenascin c may be postulated in the final maturation of the ovum , in the tubal pick up and in the complex dialogue with the tubal epithelium . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The alternatively spliced fibronectin type 3 repeat C of human tenascin C ( fnC ) provides directional cues to elongating neurites in vitro . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Quantitative differences of immunofluorescence labelling for chondroitin sulfate proteoglycan ( CSPG ) , fibronectin ( FN ) , tenascin C ( TN C ) , and thrombospondin ( TSP ) were evaluated in intact rat dorsal and ventral roots and dorsal and ventral roots 2 and 4 weeks after rhizotomy using image analysis . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
PDGF BB dependent proliferation was enhanced two to threefold by monomeric type 1 collagen or fibronectin and to a lesser extent by vitronectin ; other interstitial ECM components ( fibrillar type 1 and 3 collagen and tenascin C ) had no effect . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Only 5 genes were overexpressed in all carcinomas including fibronectin 1 ( FN 1 ) , tissue metalloproteinase inhibitor 1 ( TIMP 1 ) , biglycan ( BGN ) , tenascin C ( HXB ) , and insulin like growth factor binding protein 5 ( IGFBP 5 ) , whereas 16 genes were underexpressed . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Selective depletion of this monocytic cell population , using either clodronate liposomes or gadolinium chloride , prevented pulmonary adventitial remodeling ( ie , production of collagen , fibronectin , and tenascin C and accumulation of myofibroblasts ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The size of tenascin C monomers ( 180 250 kDa ) varies as a result of an alternative splicing of the fibronectin repeats at the pre mRNA level . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Interestingly , endostatin inhibited VEGF induced HDMEC migration following culture on collagen 1 , collagen 4 and laminin , while migration was not inhibited by endostatin following HDMEC culture on other matrices including vitronectin , fibronectin and tenascin C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Collagen 1 , 3 , and 5 ; fibronectin ; and tenascin C are deposited in the lamina reticularis . ^^^ Periostin had an ability to bind to fibronectin , tenascin C , collagen 5 , and periostin itself . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It was not inhibited by fibronectin , a chondroitin sulfate proteoglycan , or the HNK 1 monoclonal antibody , all of which are known to bind to cytotactin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Northern and Western blot analysis and in situ hybridization were used to determine localization of alternatively spliced forms of cytotactin in neural and nonneural tissues using a probe ( CT ) that detected all forms of cytotactin mRNA , and one ( VbVc ) that detected two of the differentially spliced repeats homologous to the type 3 repeats of fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Most tissues affected in this boy are of neural crest origin ; pathogenesis could be due to faulty migration along the established pathways involving either the borders ( basal laminae ) or the components of the extracellular matrix ( fibronectin , cytotactin , laminin , glycosaminoglycans , and collagen ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Although cytotactin was identified as a molecule that mediates glia neuron interactions , preliminary immunohistochemical localization of the molecule suggested that it was an ECM protein with a widespread but nonetheless more restricted distribution than either fibronectin or laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In contrast , fibronectin bound to cytotactin , but it did not bind to proteoglycan or interfere with the binding of cytotactin to proteoglycan . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In vitro , crest cells rounded up in the presence of these molecules and cell migration assays revealed that neither cytotactin nor proteoglycan alone was as good a substratum for crest cell migration as fibronectin . ^^^ In combination with fibronectin , however , cytotactin or proteoglycan only restricted cell movement but did not prevent it . ^^^ Taken together , these observations support the hypothesis that cytotactin and the chondroitin sulfate proteoglycan may contribute to pattern formation during embryogenesis by means of their site restricted distribution , their ability to alter migration on other substrates such as fibronectin , and their ability to induce cell surface modulation . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It has been shown to bind specifically to other extracellular matrix components including a chondroitin sulfate proteoglycan ( cytotactin binding [ CTB ] proteoglycan ) and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A cDNA clone for cytotactin contains sequences similar to epidermal growth factor like repeats and segments of fibronectin and fibrinogen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cytotactin binds to other extracellular matrix proteins including a chondroitin sulfate proteoglycan ( CTB proteoglycan ) and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In an effort to define the origin of such differentiation boundaries from the time of appearance of the placode , immunocytochemical methods have been used to map the developmental distributions of the cell adhesion molecules , N CAM , L CAM , and Ng CAM , and the extracellular matrix molecules , cytotactin and fibronectin , in the cochlea of the chicken embryo . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To identify potential cell surface receptors for chicken cytotactin ( CT ) , we have characterized the ability of recombinant fusion proteins spanning the proximal fibronectin ( FN ) type 3 repeats of the molecule to support attachment of glioma and carcinoma cell lines . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Control Eo ( from normal donors ) adhere no better to substrates coated with laminin ( LM ) , fibronectin ( FN ) , cytotactin ( CT ) , or collagen types 1 or 4 ( Col 4 ) than they do to human serum albumin coated substrates . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunohistochemistry revealed an apparent delay in the temporally regulated expression of cytotactin and fibronectin during cushion development . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The antibody does not react with human plasma fibronectin , chicken fibronectin or chicken cytotactin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Its localization in the neoplasms was compared with that of fibronectin and glioma mesenchymal extracellular matrix ( GMEM ) glycoprotein . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Immunoprecipitation , immunoblot , and one dimensional peptide map analysis have shown that GMEM is distinct from human fibroblast and plasma fibronectin . ^^^ These results support previous immunohistology and absorption analysis findings , indicating that GMEM is distinct from fibronectin , laminin , and glycosaminoglycans secreted by U 251MG . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The GMEM antigen is distinct from previously described forms of fibronectin , laminin , collagen types 1 to 5 , hyaluronic acid , chondroitin sulfate , and heparin , as determined by absorption analysis and immunohistological localization in tissues . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Early reports suggested that hexabrachion does not bind to fibronectin or gelatin but does bind to chondroitin sulfate proteoglycans . ^^^ However , more recent reports have suggested that hexabrachion binds to fibronectin and inhibits cell adhesion as well as cell migration on fibronectin . ^^^ We have found no evidence of strong hexabrachion fibronectin binding on either a solid phase ELISA assay or in a fluid phase sedimentation assay in which the reactants were allowed to dissociate . ^^^ However , hexabrachion sedimentation was accelerated in a gradient containing fibronectin throughout . ^^^ Moreover , hexabrachion can inhibit cell attachment to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The purification protocol gave hexabrachion at high concentration and with no detectable contamination by fibronectin or laminin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We have compared the heparin and DNA binding of hexabrachion secreted by the human glioblastoma cell line U87MG to that of fibronectin . ^^^ Using linear salt gradients , hexabrachion was eluted from heparin prior to fibronectin . ^^^ In addition , hexabrachion bound to DNA as fibronectin does , and this binding could be inhibited by heparin but not by chondroitin sulfate . ^^^ Unlike fibronectin , hexabrachion did not bind to gelatin when samples containing both proteins were passed over gelatin agarose , also indicating that there was no interaction between hexabrachion and fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Electron micrographs of the rotary shadowed molecule revealed an unusual six armed structure , indistinguishable in form and dimensions from hexabrachion , a recently discovered contaminant of cellular fibronectin preparations . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The epidermal growth factor and fibronectin 3 domains probably play an important role as spacers , placing the terminal knob at the end of the tribrachion or hexabrachion arms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Despite possessing subunits similar in size to fibronectin , myotendinous antigen appears to be both structurally and antigenically unrelated to fibronectin or to other known extracellular matrix components . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Terbinafine , an orally active antifungal agent , is effective in the treatment of dermatophyte onychomycosis when given for 12 months in the case of toenail infection ( TN ) and 6 months for fingernail infection ( FN ) . ^^^ Twenty seven patients were excluded , leaving 85 fully evaluable [ average age 44 ( range 19 78 ) years ; 55 men ; 75 TN , 10 FN ] . ^^^ Forty nine of the TN patients and seven of the FN patients received terbinafine . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The occurrence of this stromal TN immunoreactivity was closely associated with desmoplasia , recognized morphologically by an increase in fibroblastic cells and immunohistochemically by an intense staining for the connective tissue glycoprotein fibronectin ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
TN expression does not correlate with that of other ECM glycoproteins such as fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
This confirms that , as in the case of chicken , TN is mainly made up of three groups of sequences with a high homology to Epidermal Growth Factor ( EGF ) fibronectin ( FN ) type 3 repeat and fibrinogen . ^^^ The main differences with respect to the chicken TN molecule are that in the human there are 14 and half EGF like repeats compared to 13 and half in the chicken and that , as previously reported , there are 15 FN like repeats compared to 11 in the chicken . ^^^ By screening a human melanoma cDNA library in the expression vector lambda gt 11 with these Mabs and subsequently sequencing the insert of the positive clones , we have been able to localize , within the TN molecule , the epitopes recognized by two of these Mabs : BC 4 , which recognizes an epitope within the EGF like sequence and BC 2 which recognizes an epitope within the FN like type 3 repeats whose expression is regulated by alternative splicing of the TN pre mRNA . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Each TN subunit is composed of segments with high homology to the sequences of epidermal growth factor , fibronectin and fibrinogen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Nucleotide ( nt ) and deduced amino acid ( aa ) sequences revealed the characteristic primary structure , which begins with a signal peptide and TN unique sequences , follows with 14 1 / 2 epidermal growth factor ( EGF ) like repeats and 13 fibronectin type 3 repeats ( FN repeat ) , and concludes with fibrinogen homologous sequences . ^^^ Similar to chicken and human TN , the mouse TN cDNA contains five consecutive insertional FN repeats , as well as eight constitutive FN repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
To determine the influence of the degree of effort upon sensitivity and specificity , the effort criteria were compared between patients with true positive ( TP ) tests to those with false negative tests ( FN ) , and in patients with true negative ( TN ) tests compared with those with false positive ( FP ) tests . ^^^ No significant differences were detected in MHR , DUR , or DP between TP versus FN patients or between TN versus FP patients . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In four , both studies were performed ( CT / aortography TP / TP , TN / TN , TP / FN , FP / FP ) . ( FP = False Positive , TP = True Positive , FN = False Negative , TN = True Negative . ) Six received surgical repair of the aortic injury ( one death ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Up to 29 channels of somatosensory evoked potentials ( SEPs ) were recorded in 10 normal volunteers following unilateral femoral nerve ( FN ) and tibial nerve ( TN ) electrical stimulation . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The latter can be measured as diagnostic utility ( DU ) , the probability weighted sum of the utilities of the four test outcomes TP , TN , FP , and FN : DU = U ( TP ) P ( TP ) + U ( TN ) P ( TN ) + U ( FP ) P ( FP ) + U ( FN ) P ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Of 36 sites , 201Tl was true positive ( TP ) in seven sites , false positive ( FP ) in one site , true negative ( TN ) in 22 sites , and false negative ( FN ) in six sites , resulting in a sensitivity of 54 % and a specificity of 96 % . 131I MIBG was TP in four sites , FP in none of the sites , TN in 23 sites , and FN in nine sites , with a sensitivity of 31 % and a specificity of 100 % . ^^^ Immunoscintigraphy ( 102 sites overall ) was TP in 16 sites , FP in five sites , TN in 77 sites , and FN in four sites , resulting in a sensitivity of 80 % and a specificity of 94 % . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
ERPs were recorded while 10 subjects evaluated the veracity of four types of Japanese sentences ; true affirmative ( TA ) , true negative ( TN ) , false affirmative ( FA ) , and false negative ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Taking cytochromes o and b as standard for comparison , the epimastigotes samples could be grouped as follows ( in parenthesis number of passages through the culture medium ) : 1 ) stocks with a relatively high content of cytochromes b and o , prevailing the former ( stocks Y ( 116 ) , RA ( 114 ) , AF , FN , TN and MG ( 14 y 16 ) ; 2 ) stocks with a relatively low content of both cytochromes : Y ( 119 ) , AWP and UP ; 3 ) stocks with a low content of cytochrome b , without cytochrome o : CA 1 and CA 1 ( 5 ) ; 4 ) stocks without cytochromes : Y ( 117 and 118 ) and RA ( 113 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We show here that soluble TN inhibits proliferation of human T cells in response to alpha CD 3 Ab co immobilized with the extracellular matrix protein fibronectin ( FN ) . ^^^ These findings are consistent with the postulated role for TN as a natural antagonist to FN action , and suggest that T cell responses occurring at tissue sites in which TN is expressed could be influenced by its presence . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
By reverse transcriptase polymerase chain reaction through amplification of the entire fibronectin type 3 ( FN 3 ) splicing domain , two distinct TN isoforms were detected in total RNA isolated from gestational day 21 rat lung explant culture treated with TGF beta 1 and from postnatal day 8 rat lung . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Radiologic findings were categorized into the following four groups : ( 1 ) true positive ( TP ) , when the scan identified either regional or distant disease that was not appreciated on physical examination ; ( 2 ) false positive ( FP ) , when the scan showed a radiologic abnormality that either did not change for at least 6 months or was proven to be histologically benign ; ( 3 ) false negative ( FN ) , when a patient had symptoms suggestive of or suspicious for metastases and was subsequently found to have metastases , but all imaging studies were nondiagnostic ; and ( 4 ) true negative ( TN ) , when all imaging studies were negative for metastases in an asymptomatic patient . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : Of 35 CT scans , 10 were true positive ( TP ) ; three false negative ( FN ) ; 13 , true negative ( TN ) ; one , false positive ( FP ) ; and eight , equivocal . ^^^ Of 36 SPECT scans , 19 were TP ; 13 , TN ; one , FP ; one , FN ; and two , equivocal . ^^^ Of 11 MR images four were TP ; five , TN ; and two , FN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Monoclonal antibodies ( MAb ) were used to show that cultured human amnion epithelial ( HuA ) cells produce tenascins ( Tn ) and isoforms of cellular fibronectin ( cFn ) . ^^^ In immunofluorescence Tn and Fn were seen in different cytoplasmic granules upon monensin induced intracellular accumulation . ^^^ Tn appeared to be deposited in the ECM in colocalization with Fn but distinctly slower . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We reached the following conclusions : ( 1 ) compared with normal endometrial tissues , uterine sarcomas show heterogeneous , but increased , immunoreactive staining patterns exclusively within the extracellular compartment , regardless of the histologic subtype of the tumor ; ( 2 ) in vitro , all normal and transfected stromal cells and cell lines examined secreted Tn into the tissue culture medium ; ( 3 ) this secretory ability was not translated into morphologic uniformity , since immunoreactivity detected by confocal laser scanning microscopy was observed in only selected cell populations ; ( 4 ) also , the deposition and the incorporation of Tn depended upon the density of transfected cells , and ( 5 ) double staining experiments revealed that Tn could always be localized in close proximity to fibronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Transforming growth factor beta , which acts as an inducer of fibronectin , collagen , and integrin type matrix receptors , has variable effects on fibroblast TN , ranging from increased deposition in the extracellular matrix of fetal conjunctival fibroblasts to reduced secretion in newborn foreskin fibroblasts . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
IS results were classified as true positive ( TP ) , false positive ( FP ) , true negative ( TN ) or false negative ( FN ) according to the surgical data . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A regression analysis was carried out using the negative predictive value ( TN / [ TN + FN ] ) of the restorative treatment decision for dentine caries as the dependent variable . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Indeed ( 1 ) both homonymous and heteronymous soleus responses ( to electrical stimulation of the posterior tibial nerve ( TN ) and femoral nerve ( FN ) , respectively ) are clearly depressed during selective vibration of the homologous muscle ( namely soleus ( S ) or quadriceps ( Q ) ) , but remain completely unchanged during vibration of the heterologous muscle ( i . e . ^^^ Q or S ) ; ( 2 ) the effectiveness of facilitatory conditioning of FN and TN Ia afferents , respectively on the S motoneuronal pool is definitely reduced during vibration of the homologous muscle ( namely Q and S ) . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : Regarding the capacity to discriminate between neoplastic ( malignant and benign ) and nonneoplastic lesions FNAB correctly diagnosed 144 lesions ( 135 true negative [ TN ] and 9 true positive [ TP ] ) and failed in 5 cases ( false negative [ FN ] ) . ^^^ Regarding the capacity to discriminate between tumors requiring surgery or not , the FNAB diagnoses were true in 146 cases ( 83 TP , 63 TN ) and false in 3 ( 2 FN , 1 false positive ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
A recombinant fusion protein including fibronectin type 3 ( FNIII ) repeats 2 6 ( TNfn 2 6 ) was the only fragment found to promote migration of C 6 glioma cells at levels similar to that promoted by intact TN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Coexpression of fibronectin ( FN ) and TN was observed in 50 % of the TN positive cases . ^^^ However , the cases , in which TN was strongly positive in the periphery of tumors , were not reactive with anti FN antibody . ^^^ These results suggest that TN would be related to progression and metastasis of the gastric cancer , and that its biological function would be different from that of FN . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the 25 patients with SCLC 22 sites of primary tumour were correctly identified ( true positive , TP ) ; one was false negative ( FN ) and two were true negative ( TN ) , the patients being in full remission . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Probabilities associated with 80 points were p ( TM ) + p ( TN ) = . 83 and p ( FM ) + p ( FN ) = . 14 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Like TN C , TN R , and TN 10 , TN Y is a multidomain protein consisting of heptad repeats , epidermal growth factor like repeats , fibronectin type 3 like ( FNIII ) domains and a domain homologous to fibrinogen . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We investigated TN expression in intrarenal arteries with TRA , in association with cellular components , with phenotypic expression of smooth muscle cells ( SMC ) and with fibronectin expression . ^^^ Monoclonal antibodies against SMC , macrophages , T cells , B cells , fibronectin , and TN were used . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The number of true positive ( TP ) , false positive ( FP ) , true negative ( TN ) and false negative ( FN ) test results was calculated for each method as compared to the gold standard . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Four situations were defined to statistical descriptive analysis : a ) false positive ( FP ) ; b ) true positive ( TP ) ; c ) false negative ( FN ) ; and d ) true negative ( TN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Overall sensitivity , specificity and accuracy were 86 % , 72 % and 78 % , respectively , for LEUKOSCAN scintigraphy ( 12 true positives ( TP ) , 13 true negatives ( TN ) , 5 false positives ( FP ) , 2 false negatives ( FN ) ) , 93 % , 100 % and 96 % , respectively , for HMPAO LS ( 13TP , 18TN , 0FP , 1FN ) , and 100 % , 17 % and 53 . 3 % , respectively , for bone scintigraphy . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Twenty eight scans were TN , eight were TP , and one was FN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Eighteen cases were classified as being negative ( no viable HD ) , 17 true negative ( TN ) and 1 FN . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : Considering regional node basins , PET imaging demonstrated 11 true positive ( TP ) , 10 true negative ( TN ) , two false negative ( FN ) , and one false positive ( FP ) result , for an overall accuracy of 88 % . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Static images and FADS were FN in 4 patients and TN in 3 patients , and in the 2 last patients static images were FP , but FADS were TN . ^^^ Of the 10 cases of medullary carcinoma of the thyroid , static images and FADS were TN in 1 patient , static images were TP in 3 patients and FADS were TP in 2 of these patients ( and 1 FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The corneal wound healing was compared histologically , and the expression of TN and fibronectin ( FN ) on the injured cornea was examined immunohistochemically and by immunoblot analysis . ^^^ CONCLUSIONS : In suture wounds , TN appears to enhance the amount of FN expression , and a lack of TN may impair stromal cell migration . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Seventy seven consecutive cases with surgical follow up were selected from four quality assurance ( QA ) categories ( true positive , TP ; true suspicious , TS ; true negative , TN ; and false negative , FN ) . ^^^ Although the FN category showed the lowest average cellularity , the application of cellularity cutoff values as a condition of adequacy would have resulted in conspicuous numbers of cases from the `` true ' ' categories ( TN , and to a lesser degree TS and TP ) being rendered inadequate . ^^^ For example , if cases with fewer than six epithelial clusters were excluded by virtue of inadequacy , 69 % of the FN cases would have been affected , along with 40 % of the TN , 6 % of the TS , and 4 . 5 % of the TP . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Two hundred and thirteen ( 25 . 9 % ) cases had surgical follow up and were classified as true positive ( TP ) , false positive ( FP ) , true negative ( TN ) , false negative ( FN ) , true suspicious ( TS ) , or false suspicious ( FS ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Fifty three lesions were classified by PET as negative ( no viable GCT ) , 33 lesions were classified by PET as true negative ( TN ) , and 20 lesions were classified by PET as false negative ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
An approach commonly used to measure new toxicity test method ( NTM ) performance in validation studies is to divide toxicity results into positive and negative classifications , and the identify true positive ( TP ) , true negative ( TN ) , false positive ( FP ) and false negative ( FN ) results . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : For Hodgkin ' s disease , the procedures yielded 6 true positive ( TP ) results , 2 true negative ( TN ) results , and 2 false negative ( FN ) results ; for non Hodgkin lymphoma ( NHL ) , 14 TP results , 1 TN result , and 3 FN results ; and for leukemia , 4 TP results and 3 FN results . ^^^ Percutaneous biopsies yielded 16 TP results , 3 TN results , and 6 FN results . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : PET was concordant with computed tomography ( CT ) in 12 patients ( 5 TP , 6 TN , 1 FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Flocks of known status were selected and classified into 4 categories : true positive ( TP ) , FP , true negative ( TN ) , and FN ; 20 sheep per flock were submitted for blood sampling . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In this pilot study the authors examined areas on a mammogram that attracted the visual attention of experienced mammographers and mammography fellows , as well as areas that were reported to contain a malignant lesion , and , based on their spatial frequency spectrum , they characterized these areas by the type of decision outcome that they yielded : true positives ( TP ) , false positives ( FP ) , true negatives ( TN ) , and false negatives ( FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Infection demonstrated true positive ( TP ) results in 7 of 8 , true negative ( TN ) results in 2 of 7 , false positive ( FP ) results in 5 of 7 patients and one false negative ( FN ) result . ^^^ Concordant results with Mab BW 250 / 183 could only be observed in 5 of 10 patients ( 4 TP , 1 TN ) by showing 4 FP and 1 FN lesions with IF . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Group TN had lower hepatic concentration of hydroxyproline ( P < 0 . 05 ) , collagen type 1 ( P = 0 . 12 ) and type 3 ( P = 0 . 20 ) , fibronectin ( P = 0 . 05 ) , laminin ( P = 0 . 11 ) and desmin ( P = 0 . 07 ) , higher collagenolytic activity ( P < 0 . 05 ) , lower prolyl 4 hydroxylase activity ( P < 0 . 05 ) and lower prolyl 4 hydroxylase ( P = 0 . 10 ) and tissue inhibitor of metalloproteinase 1 ( P = 0 . 06 ) expression than group TS . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Out of the 25 cases of Group C , FDG PET obtained 21 TP , 1 FP case , 1 TN , 2 FN , and was able to avoid surgery in 8 patients ( PPV : 95 . 4 % and NPV : 33 . 3 % ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
These findings suggest that TGF beta 1 , HGF , and RA may regulate pulpal cell adhesion to FN coated surfaces and that this effect is mediated by TN . . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using an SUR of more than 2 . 5 , the result was TP in 2 , FP in 3 , and true negative ( TN ) in 15 , the false negative ( FN ) in 0 , with an OA of 85 % . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Overall sensitivity of EIS was 75 . 4 % , specificity 42 . 03 % , negative predictive value 66 . 7 % and positive predictive value 52 . 7 % ( 89 TP , 58 TN , 80 FP , 29 FN ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Accuracies for Down syndrome ( formula= [ ( TP + TN ) / ( TP + TN + FP + FN ) ] x 100 , where TP : true positive , TN : true negative , FP : false positive , FN : false negative ) were evaluated in four classes of CRL : 38 44 mm , 45 54 mm , 55 70 mm , and 71 84 mm , and compared . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The evaluation of PRN test results with blood alcohol concentration ( BAC ) as a reference was based on classification into the following categories and characteristics : true positives ( TP ) , true negatives ( TN ) , false positives ( FP ) , false negatives ( FN ) , sensitivity , specificity , positive predictive values ( PPV ) , negative predictive values ( NPV ) , and accuracy . ^^^ The results of the decision analyses were : TP = 584 , FP = 43 , FN = 229 , TN = 150 , sensitivity = 0 . 718 , specificity = 0 . 777 , PPV= 0 . 931 , NPV= 0 . 396 , and accuracy = 0 . 730 . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : The sensitivity and specificity of HpSA in the 56 untreated patients were , respectively , 76 % ( true positives TP = 22 ; false negatives FN = 7 ) and 93 % ( true negatives TN = 25 ; false positives FP = 2 ) . ^^^ The sensitivity and specificity of HpSA in the 29 patients on PPI treatment were , respectively , 82 % ( TP = 9 ; FN = 2 ) and 83 % ( TN = 15 ; FP = 3 ) . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
RESULTS : SPECT was true positive ( TP ) in 18 patients , true negative ( TN ) in 16 , false negative ( FN ) in ten and false positive ( FP ) in nine ; CT was TP in 18 patients , TN in 21 , FP in ten and FN in four . ^^^ With image fusion ( SPECT and CT ) , the scan result was TP in 27 patients ( 50 . 9 % ) , TN in 25 patients ( 47 . 2 % ) and FN in one patient , this FN result being caused by multiple small liver metastases ; sensitivity was 95 % and specificity , 100 % . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We observed that fibronectin and laminin accelerate spontaneous in vitro release of thymocytes from TNC , whereas anti ECM antibodies exhibited a blocking effect . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
For short term adhesion of small cerebellar neurons and PC 12 cells two binding sites were identified on TN C , one being localized within the epidermal growth factor like repeats three to five and the second within fibronectin type 3 like repeats three and four . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Antibodies to fibronectin ( FN ) and to the first FN type 3 repeat blocked both FN and TN C matrix assembly , indicating that TN C matrix organization is dependent on an FN template . ^^^ When seeded onto FN matrices , the co cultures were unaffected by the anti integrin and anti FN antibodies and were able to organize a TN C matrix . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
METHODS : Conventional and semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) with primers to alternatively spliced ( insertional ) and constitutive fibronectin type 2 like repeats of TN C was used . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Normal and PBK ABK corneas were studied by immunofluorescence and western blot analysis with antibodies to specific fibronectin type 3 like ( FN 3 ) repeats of TN C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The regulation of TN C expression in keratinocytes is distinct from that of fibronectin , since IL 4 and IFNgamma did not affect fibronectin expression in our experiments , and TNFalpha only slightly increased fibronectin levels . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The smallest TN C form contains a stretch of eight fibronectin type 3 ( FNIII ) domains , which are common to all TN C isoforms . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
In the presence of bFGF , exogenous TN C but not fibronectin induced an elongated phenotype in nonsprouting BAECs . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The antibodies included BC 4 and BC 8 , which recognize epitopes in conserved domains of TN C and can thus detect all TN C variants , and BC 2 , alpha A 2 , alpha A 3 , alpha IIIB , TN 11 , and alpha D , which bind to epitopes in alternatively spliced fibronectin type 3 repeats of TN C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
It correlated best with the expression of TN C rather than with the expression of other alphaVbeta 6 ligands , fibronectin , and vitronectin . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Cloning and sequence analysis of the PCR product indicated that SMCs express a Tn C isoform with only repeats A 1 and A 2 of fibronectin type 3 repeats . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
TN C was then compared with fibronectin ( FN ) , laminin ( LN ) , basic fibroblast growth factor ( b FGF ) and transforming growth factor beta 1 ( TGF beta 1 ) . ^^^ FN and LN induced MMP 9 to lesser extents compared with TN C . b FGF had no effect on MMP 9 expression . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Functionally , Prx 1 expression in FAK null fibroblasts restored their ability to migrate toward fibronectin , in a manner that depends on TN C . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
Using recombinant fragments of murine TN C , the functional domain responsible for promoting migration of cardiac fibroblasts was mapped to the conserved fibronectin type 3 ( FNIII ) like repeats and the fibrinogen ( Fbg ) like domain . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
We found an association between an adult asthma and an SNP encoding TNC fibronectin type 3 D ( Fn 3 D ) domain in a case control study between a Japanese population including 446 adult asthmatic patients and 658 normal healthy controls . ^^^ As the TNC fibronectin 3 domain has molecular elasticity , the structural change may affect the integrity and stiffness of asthmatic airways . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
The expression of six functionally significant genes was further validated by quantitative reverse transcription polymerase chain reaction ( RT PCR ) ( FN 1 , MMP 7 , TNC , SERPIN3A , BPHL , CSPG 2 ) in the experiment group and , subsequently , confirmed independently in 17 additional old and adult age stratified test kidney samples . ^^^
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P24821 and P02751	Pubmed	SVM Score :0.0
NA