| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| By interspecies backcross mapping using progeny derived from matings of [ ( C57BL / 6J 10 Mus spretus ) F 1 10 C57BL / 6J ] mice , the IGFBP 5 gene was localized to the proximal region of chromosome 1 in tight linkage with fibronectin 1 ( 0 recombinants in 168 mice analyzed ) . ^^^ Since this part of chromosome 1 shares homology with human chromosome 2q , and since fibronectin has been mapped to 2q34 q 36 , it is likely that human IGFBP 5 will reside on 2q as well . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| IGFBP 5 was found to bind to types 3 and 4 collagen , laminin , and fibronectin . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| The proteins encoded by these clones could be grouped into four distinct classes : extracellular matrix proteins ( fibronectin , beta ig h 3 , collagen 6 ) , enzymes ( collagenase , urokinase ) , cytoskeletal proteins ( vinculin , SM 22 ) and regulatory proteins ( beta glycan , integrin associated protein , myosin kinase , IGFBP 5 ) . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| When pSMCs were plated on fibronectin , they synthesized 6 . 0 + / 1 . 2 fold more IGFBP 5 than did cells maintained on laminin and type 4 collagen . ^^^ IGF 1 increased IGFBP 5 gene expression 3 fold in the cells plated on fibronectin . ^^^ The addition of an RGD peptide and echistatin to pSMC cultures that had been plated on fibronectin inhibited IGFBP 5 mRNA expression . ^^^ Atherosclerotic plaques from pig aorta contained abundant fibronectin and had increased IGFBP 5 mRNA ( 4 . 5 + / 1 . 5 fold ) compared with tissue from the normal vessel wall that had a low fibronectin content . ^^^ These results indicate that fibronectin , laminin , and type 4 collagen have major effects on IGFBP 5 expression and on IGF 1 stimulated pSMC responses and that these effects are mediated by their respective integrins . . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Ten microsatellites covering a region of 55 centiMorgans and eight genes ( AE 3 , FN 1 , IGFBP 5 , INHA , IRS 1 , PAX 3 , TNP 1 , and VIL 1 ) were placed on the Sscr 15 RH map . ^^^ The order of other genes already mapped in the mouse ( FN 1 , IGFBP 5 , TNP 1 , VIL 1 , INHA / AE3 , and PAX 3 ) was identical in pigs . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Differential mRNA display of normal and premalignant EVT cells identified up and down regulation of numerous known or novel genes in premalignant EVT cells , with potential oncogenic and ( or ) tumor suppressor functions , e . g . , loss of fibronectin and insulin like growth factor binding protein ( IGFBP 5 ) . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Intrinsic actions of IGFBP 3 and IGFBP 5 on Hs578T breast cancer epithelial cells : inhibition or accentuation of attachment and survival is dependent upon the presence of fibronectin . ^^^ Attachment to fibronectin , however , was increased by IGFBP 3 and decreased by IGFBP 5 . ^^^ With cells grown on fibronectin , the action of IGFBP 3 was reversed , and it conferred cell survival , whereas the survival effect of IGFBP 5 was lost . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| To elucidate the molecular mechanisms governing these diverse actions of IGFBP 5 , we screened a human cDNA library by a yeast two hybrid system using IGFBP 5 as bait and identified fibronectin ( FN ) as a potential IGFBP 5 interacting partner . ^^^ The complex formation of IGFBP 5 and FN was established by glutathione S transferase pull down , solution , and solid phase binding assays using glutathione S transferase IGFBP 5 and native IGFBP 5 in vitro and by co immunoprecipitation in vivo . ^^^ Binding assay using deletion mutants indicated that the IGFBP 5 C domain binds to the 10th and 11th type 1 repeats of FN . ^^^ IGFBP 5 potentiated IGF 1 induced cell migration in FN null , but not in wild type , mouse embryonic cells . ^^^ When FN was reintroduced either as an adhesive substrate or in solution to the FN null cells , the potentiating effect of IGFBP 5 on IGF 1 induced cell migration was abolished . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Among the differentially expressed entities were the invasion and tissue modeling related genes IGFBP 5 , fibronectin , and MMP 2 ; the cell cycle regulatory gene cyclin D 1 ; other genes , such as enolase 2 ; and an expressed sequence tag similar to angiopoietin 1 . ^^^ Antibodies for the IGFBP 5 , fibronectin , MMP 2 , cyclin D 1 , and MDM 2 proteins were used to stain tissue array sections . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Only 5 genes were overexpressed in all carcinomas including fibronectin 1 ( FN 1 ) , tissue metalloproteinase inhibitor 1 ( TIMP 1 ) , biglycan ( BGN ) , tenascin C ( HXB ) , and insulin like growth factor binding protein 5 ( IGFBP 5 ) , whereas 16 genes were underexpressed . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Increased deposition of collagen and fibronectin , increased numbers of PCNA positive fibroblasts , as well as increased numbers of vimentin and alpha SMA double positive fibroblasts were detected in the dermis of IGFBP 5 overexpressing mouse skin . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| Others corresponded to known mRNAs such as those of fibronectin , fibronectin receptor , laminin receptor homolog , beta tubulin , insulin like growth factor binding protein 5 , KIAA 0179 protein , and protease nexin 1 . ^^^ |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P24593 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
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