Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P08519 and P02751	Pubmed	SVM Score :1.4122577
Thus , fibronectin , a major liver extracellular matrix component , can interact with apolipoprotein A 1 both by downregulating its mRNA level in liver cells and by binding this molecule after its secretion in the extracellular space . 1.4122577^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.56532489
These results demonstrate that LPA collaborates with FN for persistent tyrosine phosphorylation of paxillin at both Y 31 and Y 118 , regulated by the Na+ / H+ antiporter downstream of ROCK and that this phosphorylated paxillin is essential for MM 1 cancer cell migration . . 0.56532489^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Body weight , arterial blood pressure , whole blood , plasma and serum viscosity , erythrocyte deformability , fibrinogen , fibronectin , alpha 2 macroglobulin , Von Willebrand factor antigen , triglycerides , nonesterified fatty acids , total and low density lipoprotein cholesterol , very low density lipoprotein , low density lipoprotein and apolipoprotein B levels remained unchanged throughout the study . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The plasma concentrations of albumin , transthyretin ( TTR ) , retinol binding protein ( RBP ) , vitamin D binding protein , apolipoprotein A 1 , fibronectin , orosomucoid and alpha 1 antichymotrypsin were significantly lower in the VLBW infants than in the term infants , whereas the values of alpha fetoprotein ( AFP ) were significantly higher in the VLBW infants . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The relative abundance of rat hepatic fibronectin or apolipoprotein E mRNA was not significantly altered . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Among these , the glycoproteins , apolipoprotein E and fibronectin , adsorbed most onto glass surfaces . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Amphiphilic beta strand conformations may be likely to appear in a variety of surface active proteins , including apolipoprotein B and fibronectin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Vitronectin , fibrinogen , fibronectin , heparin cofactor 2 , and apolipoprotein B were also detected in small amounts . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Serum lipids and apolipoprotein concentrations and plasma fibronectin concentrations in renal transplant patients . ^^^ We studied serum lipid , lipoprotein , and apolipoprotein concentrations and plasma fibronectin concentrations in 57 renal transplantation patients and 29 healthy controls . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The effect of dexamethasone on the synthesis of alpha 2 macroglobulin , apolipoprotein E , fibronectin and actin was examined . ^^^ Corresponding to the data obtained at the protein level , dexamethasone increased the steady state levels of alpha 2 macroglobulin specific messenger RNA and reduced apolipoprotein E specific transcripts , whereas fibronectin and actin messenger mRNA remained unchanged . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
We evaluated : blood , plasma and serum viscosity ( at shear rate of 450 ; 90 ; 4 . 5 ; 2 . 25 s 1 ) , erythrocyte deformability , haematocrit , plasma fibrinogen and fibronectin , apolipoprotein A A 1 B , triglycerides , total HDL and LDL cholesterol , FSH , LH , 17 beta estradiol , progesterone , testosterone , androstenedione , DHEA , DHEA sulfate and the estradiol / progesterone ratio ( E2 / P ratio ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Culture medium from upper and lower compartments of microplate inserts and cell lysates were immunoprecipitated after labeling with [ 3H ] glucosamine and leucine ; analysis was done by sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS PAGE ) , followed by autoradiography . [ 3H ] transferrin is found mainly in the lower compartment and in cells ; [ 3H ] apolipoprotein B is released in both compartments , and fibronectin almost entirely recovered in the lower compartment ; [ 3H ] transferrin receptors and ferritin are only present in cell lysates . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Histidine rich glycoprotein was the only plasma protein likely to influence anticoagulant activity by direct competition with antithrombin 3 , though significant quantities of complement Factor H , fibrinogen , fibronectin , vitronectin and apolipoprotein B were also detected . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Expression analysis of three senescence induced genes , i . e . , fibronectin , apolipoprotein J , and p 21 , revealed for only the fibronectin expression levels a clear positive correlation with donor age . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The dextran sulfate cellulose ( DSC ) column used for low density lipoprotein ( LDL ) apheresis adsorbs plasma constituents other than LDL that have the following characteristics : proteins containing apolipoprotein B , proteins involved in the initial contact phase of the intrinsic coagulation pathway ( coagulation factor 12 , high molecular weight kininogen and prekallikrein ) , factors with lipophilic characteristics ( coagulation factor 7 , 8 , and vitamin E ) , and proteins with adhesive or other characters ( von Willebrand factor , fibronectin , and serum amyloid P components ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
These corresponding genes include fibronectin , osteonectin , alpha 1 ( 1 ) procollagen , apolipoprotein J , SM 22 , SS 9 , and GTP alpha binding protein . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The C terminal domain of apolipoprotein ( a ) binds in vitro to the protein core of proteoglycans as well as fibrinogen and fibronectin , suggesting that this domain plays a role in anchoring lipoprotein ( a ) or free apolipoprotein ( a ) to the vascular subendothelial matrix . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In this work , we show that transforming growth factor beta 1 ( TGF beta 1 ) regulates the induction of several of these biomarkers in SIPS : cellular morphology , senescence associated beta galactosidase activity , increase in the steady state level of fibronectin , apolipoprotein J , osteonectin , and SM 22 mRNA . ^^^ In the presence of each of these antibodies , the steady state level of fibronectin , osteonectin , apolipoprotein J , and SM 22 mRNA is no more increased at 72 h after stress . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
These genes are cathepsin S , C1q B chain of complement ( C1qB ) , beta 2 microglobulin , glial fibrillary acidic protein ( Gfap ) , apolipoprotein D , fibronectin 1 and metallothionein 2 , which are expected to be involved in increased proteolysis , apoptosis and glial activation . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In addition to adsorption of LDL , DSC adsorbs plasma constituents that have the following characteristics : proteins containing apolipoprotein B ( Lp [ a ] ) ; proteins involved in the initial contact phase of the intrinsic coagulation pathway ( coagulation factor 12 , high molecular weight kininogen and prekallikrein ) ; factors with lipophilic characteristics ( coagulation factor 7 , coagulation factor 8 , and vitamin E ) ; and proteins with adhesive or other characteristics ( von Willebrand factor , fibronectin , serum amyloid P component , hepatocyte growth factor ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Apolipoprotein and fibronectin concentrations were determined with nephelometric methods . ^^^ HbA1c and triglycerides concentration are found to be significant predictors of plasma fibronectin in diabetic children , while effect of plasma cholesterol , apolipoprotein AI , B 100 and lp ( a ) are insignificant . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Preferential adsorption of apolipoprotein J , fibrinogen and fibronectin was observed . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Fibril extension was accelerated by dermatan sulfate proteoglycan , and inhibited by apolipoprotein E , alpha 1 microglobulin , fibronectin , and an antioxidant nordihydroguaiaretic acid . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Various plasma proteins were associated with the retrieved microcapsules and identified with western blotting to include Factor 11 , Factor 12 , prekallikrein , HMWK , fibrinogen , plasminogen , ATIII , transferrin , alpha 1 antitrypsin , fibronectin , IgG , alpha 2 macroglobulin , vitronectin , prothrombin , apolipoprotein A 1 , and particularly albumin , a major Ca transporting plasma protein . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
To directly test the function of EIIIA FN , we generated EIIIA null ( EIIIA ( / ) ) mice that lack the EIIIA exon and crossed them with apolipoprotein E ( ApoE ) null ( ApoE ( / ) ) mice that develop arterial wall lesions . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
We identified apolipoprotein ( apo ) D in a search for proteins upregulated in a posttranscriptional manner similar to fibronectin in motile smooth muscle cells ( SMCs ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Immunoelectron microscopy was performed , using a single labeling postembedding on grid Protein A gold method with antisera directed against laminin , fibronectin and apolipoprotein E . ^^^ In all four adenomas , anti laminin , anti fibronectin , and anti apolipoprotein E reacted with amyloid fibrils . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
An ionic interaction of positively charged regions of apolipoprotein ( apo ) B with matrix proteins , including proteoglycans , collagen , and fibronectin , is thought to initiate this process . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Elements in the C terminus of apolipoprotein [ a ] responsible for the binding to the tenth type 3 module of human fibronectin . ^^^ In previous studies , we showed that the C terminal domain , F 2 , but not the N terminal domain , F 1 , is responsible for the binding of apolipoprotein [ a ] ( apo [ a ] ) to human fibronectin ( Fn ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
However , when a rapid reorganization of the cytoskeleton was induced using lysophosphatidic acid ( LPA ) , IL2R beta 1 cells detached from FN in contrast to wild type cells . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Lysophosphatidic acid enhances fibronectin binding to adherent cells . 1 Oleoyl lysophosphatidic acid ( LPA ) enhanced binding of 125I labeled fibronectin by cultured MG 63 osteosarcoma cells and human fibroblasts in monolayer cultures up to threefold over control levels . ^^^ Increased binding was evident within 10 minutes of treatment of cycloheximide treated cells with LPA and was due to an increase in the number of fibronectin binding sites . ^^^ LPA also increased the binding of a fragment containing the 70 kDa amino terminal region of fibronectin that is primarily responsible for the reversible binding of fibronectin to matrix assembly sites on cell surfaces . ^^^ Removal of LPA resulted in prompt return of fibronectin binding to baseline levels . ^^^ These results indicate that LPA is an important enhancer of fibronectin rich matrix deposition by cultured cells , and it may be the active component in serum and lipoprotein fractions that is responsible for enhancing fibronectin deposition . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Lysophosphatidic acid ( LPA ) an intermediate for de novo lipid biosynthesis and a product of platelet activation , is a powerful serum modulator of fibronectin assembly . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
We have shown recently that lysophosphatidic acid ( LPA ) is a stimulator of FN matrix assembly . ^^^ We compared the effects of microtubule disruption and LPA on FN binding and actin cytoskeleton organization . ^^^ These effects are similar to the effects of LPA on FN binding . ^^^ Blockage of the small GTP binding protein Rho or actin myosin interactions inhibited the effects of both nocodazole and LPA on FN binding . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The neuropeptide bombesin , the bioactive lipid lysophosphatidic acid ( LPA ) , and the cytokine tumor necrosis factor alpha , which signal through diverse mechanisms , were all able to activate MAPK to a much greater degree in fibronectin adherent cells than in suspended cells . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
We have shown that Rho dependent cytoskeleton reorganization induced by lysophosphatidic acid ( LPA ) or the microtubule disrupting agent nocodazole increases fibronectin binding ( Zhang et al , Mol Biol Cell 8 : 1415 , 1997 ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Nevertheless , when the glass had been coated with fibronectin ( FN ) , LPA could induce phagokinetic motility which was accompanied by transformation of MM 1 cells to fusiform shape and assembly of focal adhesion . beta 1 integrin , the counter receptor of FN , was expressed on MM 1 cells . ^^^ Anti FN antibody , anti beta 1 integrin antibody and cyclo GRGDSPA remarkably suppressed LPA induced phagokinetic motility . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In addition , by inhibiting secretory phospholipase A 2 ( sPLA 2 ) activity and decreasing the level of lysophosphatidic acid ( LPA ) , UG may indirectly prevent the activation of integrins ( eg , alpha5beta1 ) that enhance abnormal tissue deposition of Fn . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Migration of rat ascites hepatoma ( MM 1 ) cells , invasion and phagokinetic movement were induced by the combination of lysophosphatidic acid ( LPA ) and fibronectin ( FN ) . ^^^ Y 27632 also suppressed the formation of fusiform shaped pseudopodia carrying MM 1 cells that was induced by stimulation with the combination of LPA and FN . ^^^ LPA and FN also evoked the formation of focal adhesions and actin bundles , and tyrosine phosphorylation of focal adhesion kinase ( FAK ) and paxillin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
This review focuses on modulation of cell adhesion , cell migration , collagen gel contraction , and fibronectin matrix assembly by LPA and SPP . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
This study examined whether LPA and S1P stimulate binding and assembly of fluoresceinated FN ( FITC FN ) by adherent platelets . ^^^ LPA enhanced deposition of FITC FN into linear arrays overlying platelet surfaces and on edges of platelets adherent to FN or vitronectin ( VN ) . ^^^ Deposition was greater when platelets were adherent to FN than to VN and was elicited by platelet agonists with the following order of potency : thrombin > LPA = ADP ( adenosine diphosphate ) > S1P . ^^^ RGDS ( Arg Gly Asp Ser ) or antibodies to alpha5beta1 or alphaIIbbeta 3 integrins caused a partial decrease in LPA induced deposition of FITC FN . ^^^ These observations demonstrate that LPA , thrombin , ADP , and S1P induce adherent platelets to bind and assemble FN and suggest that platelets may contribute to early deposition of FN matrix after vascular injury . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Activation of RhoA activity with lysophosphatidic acid ( LPA ) increased 2 fold the adhesion of monocytic cells to Fn in a alpha5beta1 mediated fashion , and IFN gamma treatment reversed the enhancing effect of LPA . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
LPA stimulates fibronectin secretion and filopodia extension in airway epithelial cells as well as proliferation and collagen gel contraction by lung fibroblasts . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Treating the CBD adherent fibroblasts with LPA , to activate Rho , or the tyrosine phosphatase inhibitor sodium vanadate increased the level of phosphorylation of Tyr ( 397 ) to match that of cells plated on FN . ^^^ The phosphorylation levels of FAK Tyr ( 397 ) were lower in FN adherent syndecan 4 null fibroblasts compared with syndecan 4 wild type and these levels were rescued by the addition of LPA or re expression of syndecan 4 . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In this study , transient overexpression of Edg 2 sensitized MG 63 human osteosarcoma cells to both LPA and S1P mediated stimulation of fibronectin matrix deposition and actin stress fiber formation . ^^^ These results indicate that , in MG 63 cells , Edg 2 mediates actin stress fiber formation , fibronectin matrix assembly , and MAPKinase activation in response to either LPA or S1P . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
BACKGROUND : Co stimulation with lysophosphatidic acid ( LPA ) and fibronectin ( FN ) is essential for migration of rat ascites hepatoma MMI cells . ^^^ We examined the roles of LPA and FN in Rho FAK pathway to migration . ^^^ MATERIALS AND METHODS : We evaluated the morphology , phagokinetic motility and the status of Rho activation and tyrosine phosphorylation of FAK after stimulation of MMI or HT 1080 cells with LPA + FN or each alone . ^^^ RESULTS : On FN coated dishes without LPA , MM 1 cells could not migrate and harbored undetectable levels of activated RhoA . ^^^ Stimulation with LPA + FN enabled the MM 1 cells to migrate and bear active RhoA and sustained tyrosine phosphorylation of FAK . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
We demonstrated previously that rat ascites hepatoma MM 1 cells require both lysophosphatidic acid ( LPA ) and fibronectin ( FN ) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase ( FAK ) . ^^^ To examine this , total cellular lysates after stimulation with LPA or FN were subjected to time course immunoblot analysis with anti phophotyrosine and anti pY 397 FAK antibodies . ^^^ Tyrosine phosphorylation of FAK especially at Tyr 397 was obviously persistent after stimulation with LPA + FN compared to after stimulation with LPA alone . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Cells were then evaluated by immunocytochemistry , western blot , collagen gel contraction and LPA stimulation to measure : ( 1 ) focal adhesion ( FA ) , fibronectin ( FN ) and f actin assembly ; ( 2 ) expression of alpha smooth muscle actin ( alpha SMA ) ; ( 3 ) ability to contract extracellular matrix and ( 4 ) determine contractile ability , respectively . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In addition , an in vitro caspase 3 activity assay was used to determine that caspase 3 activity was higher in epithelia treated with 10 microM Y 27632 than in those isolated without the basal lamina or epithelia stimulated with fibronectin , COL , or LPA . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
RESULTS AND CONCLUSIONS : BPAEs responded to LPA by transmigration through gelatin or collagen coated filters , but not through fibronectin , vitronectin , or fibrinogen coated filters . ^^^ LPA stimulated lamellipodia on fibronectin , but the trailing edge remained attached , resulting in sting ray shaped cells in video microscopy . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The ability of FN to adhere to VSMC ( binding probability ) was significantly reduced by integrin antagonists , serum starvation , and platelet derived growth factor ( PDGF ) BB , whereas lysophosphatidic acid ( LPA ) increased FN binding . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
LPA stimulated concanavalin A mediated formation of caps , chemotaxis , invasion of extracellular matrix substrates , and erythrophagocytosis , but not binding to fibronectin . ^^^ ROCK inhibition impaired LPA stimulated functions and to some extent adhesion to fibronectin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The binding of Lp ( a ) was localized to the C terminal heparin binding domain of fibronectin . ^^^ Incubation of Lp ( a ) with fibronectin resulted in fragmentation of fibronectin . ^^^ The cleavage pattern , as visualized by gel electrophoresis and immunoblotting , was reproducibly obtained with Lp ( a ) purified from five different individuals and was distinct from that obtained upon proteolysis of fibronectin by plasmin or kallikrein . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The spatial relationships of midline axial structures were compared in normal and dysraphic embryos of the loop tail ( Lp ) mutant mouse at 9 days of gestation , and the distribution of two glycoproteins , fibronectin and laminin , was determined in this region by means of immunofluorescence histochemistry . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Using SDS PAGE and immunoblot and dot blot techniques , we found that the major proteins associated with LP were albumin and fibronectin , whereas apoB and apoE were present in lower amounts . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The cells were exposed to 0 . 05 % agent with or without saliva , LP , mucin or catalase ( as a positive control based on our previous study ) and assessed for effect on viability / morphology ( by microscopic observation ) , proliferation ( by [ 3H ] thymidine incorporation ) , and the production of fibronectin ( FN ) and type 1 collagen ( by ELISA ) . ^^^ While the bleaching agent at 0 . 05 % caused cell death , the cells appeared viable and morphologically normal when treated with the bleaching agent and LP ( > or = 0 . 1 microM ) , saliva LP , and catalase from agent inhibition of proliferation ( P < or = 0 . 04 ) and FN production ( P < or = 0 . 01 ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Interestingly , in contrast to the FAK / cells , which exhibit an increased number of prominent focal adhesions when plated on fibronectin , FAK knockdown IEC 18 cells exhibited dramatically decreased number of focal adhesions in response to both LPA and fibronectin as compared with the control cells . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Fibronectin is a plasma protein that is insolubilized into fibrils in a regulated fashion by , for example , lysophosphatidic acid ( LPA ) stimulated fibroblasts or platelets spread on supportive adhesive ligands . ^^^ OBJECTIVE : To study assembly of plasma fibronectin by LPA activated platelets adherent to LN 111 via alpha6beta1 integrin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The apo ( a ) portion of Lp ( a ) was recently shown to have serine proteinase type amidolytic activity and to be able to degrade the adhesive glycoprotein fibronectin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The apo ( a ) portion of Lp ( a ) binds to the carboxy terminal heparin binding domain of fibronectin . ^^^ Incubation of Lp ( a ) or isolated apo ( a ) with fibronectin results in proteolytic cleavage of fibronectin which is , as visualized by gel electrophoresis and immunoblotting , distinct from that caused by plasmin or kallikrein . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
To test whether removal of HSPG exposes fibronectin , a candidate Lp ( a ) binding protein in the matrix , antifibronectin antibodies were used . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The influence of serum lipoprotein ( a ) [ Lp ( a ) ] and fibronectin on vascular access occlusion has not been widely studied despite their theoretical or demonstrated importance in vascular bypass occlusion . ^^^ Variables tested included age , race , gender , diabetes , access type ( PTFE 5 endogenous ) , treatment time , systolic BP , hematocrit , heparin and erythropoietin dosage , and serum levels of Lp ( a ) and fibronectin . ^^^ In univariate analysis , access occlusion was associated with age , diabetes , PTFE , Lp ( a ) > or = 57 mg / dL , serum fibronectin , and reduced BP . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
This study was designed to compare plasma levels of Lp ( a ) in 100 white male patients with and without peripheral vascular disease ( PVD ) and to determine the role of Lp ( a ) as a risk factor for PVD independent of known risk factors such as cigarette smoking ( CIG ) , diabetes mellitus ( DM ) , and coronary artery disease ( CAD ) . ^^^ However , there was no statistically significant difference in Lp ( a ) levels in patients with CIG or CAD compared to those without . ^^^ Stepwise regression analysis of these various risk factors for PVD revealed that Lp ( a ) was the strongest significant individual predictor for the presence of PVD ( R 2 = 0 . 07 ) as compared to DM ( R 2 = 0 . 05 ) and CIG ( R 2 = 0 . 04 ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Nonreducible collagen crosslinks ( hydroxylysylpyridinoline [ HP ] and lysylpyridinoline [ LP ] ) were significantly greater in the older exercise and age matched control L 6 and FN . ^^^ In the weightbearing FN but not L 6 the LP concentration of the exercise group was significantly greater than the age matched controls . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The effects of zopiclone 10mg ( ZP ) , flunitrazepam 1mg ( FN ) , triazolam 0 . 25mg ( TZ ) and levomepromazine 5mg ( LP ) on two models of sleep wake schedule change 6 hours advanced shift : ( A shift ) , and 6 hours delayed : ( D shift ) were investigated in 6 healthy volunteers using polysomnography . 2 . ^^^ LP and FN caused some inadequate conditions on the following days . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Lp ( a ) has a great tendency to aggregate and bind to glucosaminoglycans , fibrin and fibronectin and is preferentially retained in the extracellular matrix during development of atherosclerosis and is in vitro phagocytosed by macrophages , probably as small aggregates . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The importance of Lp ( a ) fibronectin interaction in atherogenesis . ^^^ The apo ( a ) portion of Lp ( a ) binds to the carboxyterminal heparin binding domain of fibronectin . ^^^ Lp ( a ) bound to fibronectin is internalized through the fibronectin receptor pathway and thereby causes increased accumulation of lipid and foam cell formation . ^^^ In the present study , fibronectin and Lp ( a ) concentrations have been assayed in patients with coronary heart disease ( CHD ) and healthy subjects . ^^^ Plasma fibronectin ( p < 0 . 05 ) and serum Lp ( a ) ( p < 0 . 001 ) levels were found to be significantly elevated when compared with the control group . . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Lp ( a ) does not alter autocrine transforming growth factor beta transcription in human mesangial cells and has , unlike low density lipoprotein , no effect on the production of the extracellular matrix protein fibronectin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In the case of Lp [ a ] , elastase digestion generates a miniLp [ a ] particle , which contains the apo [ a ] COOH terminal domain able to bind to lysine , fibrinogen , fibronectin , and proteoglycans . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Moreover , PLA 2 treatment of Lp ( a ) enhanced its binding to individual matrix proteins ( fibronectin , laminin , or collagen ) by 4 10 times above that of LDL . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
However , neither collagen nor fibronectin were capable of blocking or displacing [ 125I ] Lp ( a ) from the lipase bound to ECM . ^^^ In a separate set of experiments , when ECM was not saturated with lipase , both fibronectin and collagen ( at 10 fold protein excess ) prevented approximately 40 % of total [ 125I ] Lp ( a ) retention to ECM . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
In particular , studies on chemokine induced alterations of LP CD34+ cell attachment to fibronectin coated plastic surfaces , proliferation of these cells in colony forming cell ( CFC ) assays and intracellular calcium mobilization were performed . ^^^ MIP 1alpha but not SDF 1alpha was found to increase the adhesion of LP CD34+ cells to fibronectin in a dose dependent manner . ^^^ In conclusion , our data suggest distinct biological properties of SDF 1alpha and MIP 1alpha in terms of modulation of LP CD34+ cell adhesion to fibronectin and intracellular calcium levels . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Binding of defensin / Lp ( a ) complexes to matrix was inhibited ( > 90 % ) by heparin and by antibodies to fibronectin ( > 70 % ) , but not by antibodies to vitronectin or thrombospondin . ^^^ Defensin increased the binding of Lp ( a ) ( 10 nmol / L ) to purified fibronectin more than 30 fold . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Addition of either purified low density lipoprotein ( LDL ) or fibronectin to the purified Lp [ a ] at a 1 : 1 molar ratio reduced the Lp [ a ] Lys ( + ) fraction ( maximal decrease of 34 and 20 % , respectively ) whereas addition of both fibronectin and LDL to the purified Lp [ a ] resulted in a further decrease ( 45 % maximally ) in this fraction . ^^^ Taken together , our data suggest that the lysine binding heterogeneity of plasma Lp [ a ] is not primarily an intrinsic property of the lipoprotein , but rather results in large part from its ability to noncovalently associate with abundant plasma components such as LDL and fibronectin . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The LP diet significantly reduced the progression of tubular injury , depositions of fibronectin , tubulointerstitial myofibroblast formation , the interstitial expression of TGF beta positive cells ( at 14 days ; NP = 6 . 91 + / 3 . 35 vs . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
The remaining portions of these proteins ( residues 481 to 650 ) contain four putative fibronectin binding repeats highly similar to those of other streptococcal fibronectin binding proteins and a potential LP ( 10 ) SG cell wall anchor motif . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
Fibronectin staining was detected in the Lp and the muscular layer . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
OBJECTIVE : To determine MMP 2 , MMP 3 , MMP 9 and FN expressions in LP and discuss the possible associations . ^^^ CONCLUSION : Loss of MMP 2 , MMP 3 and FN in LP can be explained with the destruction of the epidermal basal layer . ^^^
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
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Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08519 and P02751	Pubmed	SVM Score :0.0
NA