| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.86735896 |
| Decorin , an interstitial small proteoglycan , was shown to interact with fibronectin via its core protein . 0.86735896^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.61396396 |
| In a solid phase ligand binding assay the versican and decorin like molecules interacted with fibronectin , but not with laminin or collagen types 1 and 4 . 0.61396396^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.9533271 |
| Using radioiodinated decorin as ligand for the immobilized fusion proteins , a binding site that interacted with the decorin core protein could be assigned to the NH 2 terminal fibronectin type 3 repeat of collagen 14 . 0.9533271^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Decorin , a ubiquitous small interstitial dermatan sulfate proteoglycan , interacts with several extracellular matrix components , e . g . , with type 1 collagen and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Furthermore , within the core of these repeats was the consensus protein sequence NKISK which has been proposed to be the fibronectin binding region of decorin ( G . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Most of the active TGF beta released from platelets after degranulation was associated with TSP , as demonstrated by anti TSP immunoaffinity and gel permeation chromatography . 125I TGF beta binds to purified TSP in an interaction that is specific in the sense that bound TGF beta could be displaced by TGF depleted TSP but not significantly by native TSP , heparin , decorin , alpha 2 macroglobulin , fibronectin , or albumin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Influence of decorin on fibroblast adhesion to fibronectin . ^^^ When cell binding fragments of fibronectin were used as substrates , a similar inhibition of cell adhesion by decorin core protein was found , and in vitro assays demonstrated an interaction of core protein with the cell binding domain of fibronectin . ^^^ Decorin core protein also inhibited the low degree of cell adhesion to heparin binding fragments on the N terminus and near the C terminus of the fibronectin molecules . . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Specifically , the expression of types 1 and 4 collagens , fibronectin , and decorin proteoglycan genes were markedly inhibited , whereas that of versican proteoglycan and beta actin genes were unaffected . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Not only have specific bone cell matrix components ( collagen , osteonectin , the large chondroitin sulfate proteoglycan , biglycan , and decorin ) been found to be present in reduced levels in OI bone cells , but some matrix components ( thrombospondin , fibronectin , and hyaluronan ) have also been found to be present in elevated levels in the matrix of OI cells . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The expression of extracellular matrices ( ECMs ) laminin ( LN ) , type 4 collagen ( 4 C ) , heparan sulphate proteoglycan ( HS PG ) , fibronectin ( FN ) , tenascin ( TN ) , decorin and vitronectin ( VN ) was examined immunohistochemically in 112 primary tumours and 29 metastatic cervical lymph nodes in oral squamous cell carcinoma ( OSCC ) . ^^^ In peritumour stroma in metastatic lymph nodes , LN , 4 C , HS PG , decorin and VN were weakly expressed , while FN and TN were strongly expressed . ^^^ Furthermore , in primary tumours of metastatic cases , the expression of LN , 4 C , HS PG , decorin and VN obviously decreased , while the expression of FN and TN increased when compared with those of the non metastatic cases . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The appearance of extracellular matrix ( ECM ) components which may regulate the developmental processes in the human embryonic axial mesenchyme and the notochord was studied in 5 human embryos between Carnegie stages 12 and 14 ( 4th and early 5th gestational wk ) by using Alcian blue histochemistry and immunohistochemistry with antibodies against types 1 and 2 collagens , the proteoglycans aggrecan , biglycan and decorin , the glycoproteins fibronectin , laminin and tenascin and the growth factor TGF beta . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recent studies from our laboratory have identified the nonaggregating , collagen binding proteoglycans , fibromodulin ( FM ) and decorin , and fibronectin ( Fn ) and albumin , noncovalently bound at the articular surface of cartilage . ^^^ Interactions of collagen and Fn with either FM or decorin were studied by radioimmunoassay of the same surfaces , using specific antibodies . ^^^ The present studies show that 1 ) Fn is immunologically detectable at the intact articular surface of cartilage ; 2 ) fibroblast adhesion to Fn is inhibited by cartilage surface extract proteins and by purified FM , but not by purified decorin ; 3 ) FM has binding affinity for Fn ; 4 ) FM interferes with the binding of a monoclonal antibody specific for the cell binding domain of Fn ; and 5 ) FM and decorin inhibit collagen dependent fibroblast adhesion . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Control tissue was characterized by polymorphous cells , showing cytoplasmic microfilament bundles , numerous pinocytic vesicles , basement membrane like structures , and a thick coat of interwoven filaments , and by type 1 and 3 positive heterogeneous collagen fibrils , fibronectin , vitronectin , decorin and proteoglycans . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The tissue distributions of TGF beta 1 , the TGF beta 1 binding proteoglycan decorin , fibronectin , and the alpha 5 beta 1 fibronectin receptor were assessed immunohistochemically . ^^^ We further demonstrated decorin , fibronectin , and the alpha 5 beta 1 fibronectin receptor within nonnecrotizing granulomas and in the fibrous tissue surrounding the lesions . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| After 3 to 6 weeks of culture in Biobrane the HF proliferated and secreted matrix proteins including type 1 collagen , fibronectin , and decorin , as well as messenger RNA for several growth factors ( acidic fibroblast growth factor , basic fibroblast growth factor , and keratinocyte growth factor ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Tissue sections were stained with an indirect immunoperoxidase technique using antibodies against collagen 1 , 3 , 4 , 5 , 6 , laminin , fibronectin , decorin and heparansulphate proteoglycan core protein ( HSPG ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| We here investigated immunohistochemically the expression of other components of the extracellular matrix ( ECM ) , including collagen type 4 , heparan sulfate proteoglycan can ( HSPG ) , chondroitin 4 sulfate proteoglycan , decorin , and fibronectin in adhalin deficiency , compared with other types of muscular dystrophy . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Other major ECM abnormalities in PBK / ABK corneas compared to normals included : discontinuous epithelial BM straining for laminin 1 ( alpha 1 beta 1 gamma 1 ) , entactin / nidogen and fibronectin ; accumulation of fibronectin and alpha 1 alpha 2 type 4 collagen on the endothelial face of the Descemet ' s membrane ; and abnormal deposition of stromal ECM ( tenascin , fibronectin , decorin , types 1 , 3 , 5 , 6 , 8 , 12 , 14 collagen ) and BM components ( type 4 , collagen , perlecan , bamacan , laminin 1 , entactin nidogen , fibronectin ) in SEF areas and in PCL . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The expression of a series of ECMs laminin , type 4 collagen , heparin sulphate proteoglycan , fibronectin , tenascin , decorin , and vitronectin was immunohistochemically examined . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Slot blot analysis showed 2 3 fold increases in mRNAs for collagen type 1 , fibronectin , versican and perlecan , whereas mRNA for decorin was increased by up to 20 fold . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| These include changes in the distribution of collagen types 1 , 2 , 3 , 4 and 6 ; the proteoglycans decorin and lumican ; as well as the adhesive glycoproteins tenascin , fibronectin and laminin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| We analyzed the expression of other extracellular matrix proteins by Western and Northern blot analyses , and found that adhesion molecules , fibronectin , and type 1 collagen , were increased , whereas an anti adhesion molecule , tenascin , was decreased , like decorin . ^^^ Subsequently , decorin was purified from bovine tendons , and cultured with these fibroblasts in fibronectin depleted culture medium . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In relation to basal levels , endothelin 1 increased the mRNA levels of collagen 1 and fibronectin at 24 h ( 130 + / 9 % and 132 + / 18 % , respectively ) , but did not modify the expression of decorin core proteoglycan . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Using a solid phase assay , we have characterized its binding affinity for extracellular matrix components known to interact with tissue derived decorin including collagen type 6 , collagen type 1 , and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| However , HMW did not bind to fibronectin , decorin and heparin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Decorin induced the expression of the matrix metalloproteinase collagenase ( MMP 1 ) when present on the substrate with vitronectin , or with the 120 kDa cell binding domain of fibronectin , but not when present with intact fibronectin or Type 1 collagen . ^^^ Secreted collagenase was detected within 8 h of adhesion , there was no associated alteration in cell shape or focal contact formation in cells adhering to decorin plus vitronectin , whereas cell rounding was observed in cells adhering to decorin plus the 120 kDa fragment of fibronectin . ^^^ The core protein of decorin , but not the glycosaminoglycan moiety , was sufficient to induce collagenase expression on both substrates ; however , the glycosaminoglycan moiety of decorin as well as the core were required for cell rounding observed in cells adhering to the 120 kDa domain of fibronectin . ^^^ These data indicate that decorin has specific gene regulatory effects in cells when present in the matrix with vitronectin or the 120 kDa fragment of fibronectin , polypeptides that are present in actively remodeling tissues . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Several matricellular proteins , proteoglycans , and growth factors bind to type 1 collagen , e . g . , fibronectin , secreted protein acidic and rich in cysteine ( SPARC ) , decorin , and transforming growth factor beta . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In order to investigate these mechanisms , expression of extracellular matrix molecules ( ECM ) ( undulin , decorin , tenascin , laminin , and fibronectin ) and cytokines [ transforming growth factor ( TGF ) beta 1 , TGF beta 3 , platelet derived growth factor ( PDGF ) , and PDGF receptor ] were semiquantitatively evaluated in chronically rejected lung allografts , using standard immunohistochemical techniques . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition decreased decorin but unchanged type 4 collagen and fibronectin mRNA levels were found . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunoelectron microscopic investigations revealed collagen type 2 , fibronectin , decorin and chondroitin sulfate proteoglycans in the chondrocyte capsules and in mass culture . . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| TGF beta stimulates production of ECM components such as collagen 4 , fibronectin , proteoglycans ( decorin and biglycan ) without increasing HSPG . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In post proliferative cell strains , rhIGF 1 ( 0 . 1 100 ng / ml ) increased levels of type 1 collagen , biglycan and decorin , and to a smaller extent fibronectin and thrombospondin , whereas it decreased the levels of hyaluronan and a versican like proteoglycan when protein and proteoglycan metabolism were followed by steady state radiolabelling with [ 3H ] proline , [ 3H ] glucosamine or [ 35S ] sulphate . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The first comprised a narrow glycocalyx , 1 3 microns in width , which consolidated over time and was rich in collagen types 2 , 6 , 9 and 11 , fibronectin , decorin and the aggrecan epitopes , 5D4 and HABR . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The frozen sections were stained with an indirect immunoperoxidase technique using antibodies against collagen types 1 , 4 , 5 , 6 , laminin , fibronectin , decorin and heparansulphate proteoglycan core protein . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| All three HERKO lines expressed high amounts of collagen 1A1 , osteopontin , osteonectin , fibronectin , decorin , biglycan , and alkaline phosphatase . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| LTD 4 ( 0 . 1 or 10 microM ) did not increase the total messenger RNA expression of the extracellular matrix proteins ( pro alpha [ 1 ] type 1 or alpha 1 [ 4 ] type 4 collagen ) , elastin , biglycan , decorin , and fibronectin , and did not influence tumor growth factor beta ( 10 ng / ml ) induced effects on the expression of these proteins in HASM cells . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin , decorin , and biglycan were also detected in smaller amounts . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In an effort to obtain a more integrated understanding of vascular stroma formation in breast carcinoma , we examined expression of the angiogenic factor vascular permeability factor ( VPF ) / vascular endothelial growth factor ( VEGF ) ; the VPF / VEGF receptors flt 1 and KDR ; thrombospondin 1 , which has been reported to inhibit angiogenesis ; and the stromal components collagen type 1 , total fibronectin , ED A+ fibronectin , versican , and decorin by mRNA in situ hybridization on frozen sections of 113 blocks of breast tissue from 68 patients including 28 sections of breast tissue without malignancy , 18 with in situ carcinomas , 56 with invasive carcinomas , and 8 with metastatic carcinomas . ^^^ A characteristic expression profile emerged that was remarkably similar in invasive carcinoma , carcinoma in situ , and metastatic carcinoma , with the following characteristics : strong tumor cell expression of VPF / VEGF ; strong endothelial cell expression of VPF / VEGF receptors ; strong expression of thrombospondin 1 by stromal cells and occasionally by tumor cells ; and strong stromal cell expression of collagen type 1 , total fibronectin , ED A+ fibronectin , versican , and decorin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Further , the decorin core protein binds to growth factors , including transforming growth factor beta ( TGF beta ) , to other intercellular matrix molecules such as fibronectin and thrombospondin , and to the decorin endocytosis receptor . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In contrast to the other three MT MMPs ( MT 1 , MT 2 , and MT 3 MMP ) , the catalytic domain of MT 4 MMP does not activate progelatinase A , nor does it hydrolyze one of the offered extracellular matrix ( ECM ) proteins , such as collagen types 1 , 2 , 3 , 4 , and 5 , gelatin , fibronectin , laminin or decorin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Four human glioblastoma cell lines ( U373MG , U138MG , U251MG , GaMG ) as well as four human melanoma cell lines ( MV 3 , BLM , 530 , IF 6 ) were tested with semiquantitative RT PCR for their ability to express mRNA of different human ECM components ( fibronectin , decorin , tenascin , collagen 1 , collagen 4 , versican ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis also showed that interleukin 1 antisense decreased the expression of matrix genes such as type 1 collagen , fibronectin , and decorin similar to downregulation after heparin / endothelial cell growth supplement treatment . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Important constituents of extracellular matrix are collagen , fibronectin , hyaluronan , and various types of proteoglycans , such as versican , perlecan , decorin , and biglycan . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , endothelial cells that express decorin assemble an extensive fibrillar fibronectin matrix more rapidly than control cells as assessed by immunocytochemical and fibronectin fibrillogenesis assays . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The pentapeptide NKISK has been reported to inhibit the binding of decorin , a proteoglycan on the surface of collagen fibrils , to fibronectin , a tissue adhesion molecule . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Enzyme linked immunosorbent assays were done with antibodies to human fibronectin ; perlecan ; elastin ; the laminin beta ( 1 ) , gamma ( 1 ) , beta ( 2 ) , alpha ( 1 ) chains ; thrombospondin ; chondroitin sulfate ; collagen types 1 , 3 , 4 , and 5 ; versican ; and decorin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Effect of interleukin 10 on the gene expression of type 1 collagen , fibronectin , and decorin in human skin fibroblasts : differential regulation by transforming growth factor beta and monocyte chemoattractant protein 1 . ^^^ In this study , we investigated the effect of IL 10 on gene expression of extracellular matrix ( ECM ) proteins , such as type 1 collagen , fibronectin , and decorin , in human skin fibroblasts . ^^^ Results of Northern blot analysis showed that both collagen 1 and fibronectin mRNAs were downregulated , while decorin gene expression was enhanced by IL 10 ( 10 ng / ml ) time dependently ( 6 24 h ) . alpha 1 ( 1 ) collagen and fibronectin mRNAs were decreased to one third and one fourth , respectively , by 50 ng / ml IL 10 , whereas decorin mRNA was increased up to 2 . 7 fold by 50 ng / ml IL 10 . ^^^ Response to IL 10 by scleroderma fibroblasts was similar to that in normal dermal fibroblasts , with decreased expression levels of collagen and fibronectin and induced decorin mRNA levels . ^^^ Transforming growth factor beta ( TGF beta ) is a crucial fibrogenic cytokine which upregulates the mRNA expression of collagen and fibronectin , whereas it downregulates decorin mRNA expression in fibroblasts . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Bleomycin increases steady state levels of type 1 collagen , fibronectin and decorin mRNAs in human skin fibroblasts . ^^^ In this study , the effects of bleomycin on gene expression of extracellular matrix encoding alpha 1 ( 1 ) collagen , fibronectin and decorin were determined in vitro in human dermal fibroblasts . ^^^ Northern blot analysis showed that bleomycin upregulated alpha ( 1 ) collagen , fibronectin and decorin gene expression dose dependently between 1 nM and 1 microM . ^^^ Bleomycin at 100 nM upregulated alpha 1 ( 1 ) collagen , fibronectin and decorin mRNA expression with a peak at 6 h following stimulation in normal skin fibroblast monolayers . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Partial transformation induced by ATF 3 was found to be associated with repression of multiple cellular genes that are also down regulated by 5 Jun , including those coding for the extracellular components fibronectin , decorin , thrombospondin 2 , and the pro apoptotic protein Par 4 . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| An extract of cartilage surface small proteoglycans ( SE ) and purified fibromodulin ( FM ) , decorin ( DCN ) , biglycan ( BGN ) , and aggrecan ( AGN ) on the surface of normal cartilage were used to test for inhibition of Fn dependent cell adhesion . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Moreover , both the M and RT derived cells were found to express higher levels of the extracellular matrix ( ECM ) proteins collagen type 1 , fibronectin , tenascin , and decorin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The pentapeptide NKISK has been reported to inhibit the binding of decorin to fibronectin . ^^^ This study demonstrates that inhibition of decorin / fibronectin binding by NKISK results in tendon lengthening in an in vivo setting as noted by a progressive increase in the length of the patellar tendon . . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| These included heat shock protein 90 , decorin , fibronectin , ferritin heavy chain , and keratocan . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Comparison of messenger RNA gene expression of extracellular matrix proteins ( procollagen 1 , collagenase , elastin , hyaluronic acid synthase 2 , hyaluronidase , fibronectin , cd 44 , fibromodulin , and decorin ) across cell passages ( 3 , 4 , 5 , 6 , 10 , and 12 fornormal laminapropria and 3 , 4 , 5 , 6 , and 10 for tracheal scar ) revealed varied growth patterns . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies specific for major ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^ Fibronectin , fibrillin 1 , MAGP 1 , decorin , and type 6 collagen were all localized to clusters of the banded material in the sheath surrounding the core , where several types of collagen , glycoproteins , and proteoglycans were also detected . ^^^ Myocilin was found to associate mainly with the sheath material , overlapping extensively in distribution with fibronectin , fibrillin 1 , and MAGP 1 and moderately with decorin and type 6 collagen . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Several genes were underexpressed by at least 50 % in both tumor types such as c fos , decorin , alpha 2 macroglobulin , platelet endothelial cell adhesion molecule 1 , EGR 1 , and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The genes studied included collagen Type 1 ( Col 1 ) , collagen Type 2 ( Col 2 ) , decorin , fibronectin ( FN ) , interleukin 1a ( IL 1alpha ) , bone morphogenetic protein 2 ( BMP 2 ) , Fas , matrix metalloproteinase 1 ( MMP 1 ) , matrix metalloproteinase 9 ( MMP 9 ) , matrix metalloproteinase 13 ( MMP 13 ) , and tumor necrosis factor ( TNF ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Cells with increased decorin synthesis showed a 61 % decrease of TGF beta ( 1 ) mRNA , a 71 % reduction of alpha 1 collagen type 4 mRNA , and a 29 % reduction of fibronectin mRNA . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The mammalian receptors for B . burgdorferi that have been most thoroughly studied , and for which candidate bacterial ligands have been identified , are decorin , fibronectin , glycosaminoglycans , and beta 3 chain integrins . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Decorin is a small leucine rich proteoglycan able to interact with several molecules of the subendothelial matrix , such as collagen and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The mammalian receptors for B . burgdorferi that have been most thoroughly studied , and for which candidate bacterial ligands have been identified , are decorin , fibronectin , glycosaminoglycans , and beta 3 chain integrins . . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The cartilage specific fibronectin isoform has a high affinity binding site for the small proteoglycan decorin . ^^^ Binding of fibronectin to the small proteoglycan decorin plays an important role in cell differentiation and cell migration . ^^^ Dissociation constants for decorin and fibronectin interaction were calculated to be 93 nm for the 5 ( + ) C ( + ) isoform and 24 nm and 223 nm for ( V+C ) ( ) fibronectin . ^^^ Because heparin competed with decorin competitively , binding of decorin to fibronectin likely occurs at a heparin binding region . ^^^ We propose that alternative splicing of the 5 and C regions changes the global conformation of fibronectin in such a way that it opens an additional decorin binding site . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Relative to C2C12 cells , BC3H1 cells underaccumulated cyclin dependent kinase inhibitor p 21 and underaccumulated transcripts for p 21 , GADD 45 , CDO , decorin , osteopontin , H 19 , fibronectin , and thrombospondin 1 ( tsp 1 ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Link protein and fibronectin mRNA were increased by the glucocorticoids , and biglycan and decorin were minimally affected . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Antibodies to biglycan and decorin as well as to other known and extensively investigated cartilage matrix components such as type 2 collagen , aggrecan and fibronectin were investigated . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In vitro analysis showed that stimulation with monocyte chemoattractant protein 1 ( 10 ng per mL ) upregulated alpha 1 ( 1 ) collagen and decorin mRNA expression in normal dermal fibroblasts , whereas mRNA levels of fibronectin and biglycan were not altered . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Using a rabbit model , interstitial proteins decorin , fibromodulin , and fibronectin were examined immunohistologically , two months postinduction of vocal fold scar by means of forcep biopsy . ^^^ Significantly decreased decorin and fibromodulin with significantly increased fibronectin characterized scarred vocal fold tissue . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expressions of specific genes , shown to be regulated in the cDNA array analysis , were analyzed in the individual samples using real time PCR . cDNA arrays showed that gene expressions for matrix metalloproteinase 2 ( MMP 2 ) , fibronectin subunit B ( FNRB ) , vascular endothelial growth factor ( VEGF ) , and mitogen activated protein kinase p 38 ( MAPKp 38 ) were up regulated , while matrix metalloproteinase 3 ( MMP 3 ) and decorin were down regulated , in tendinosis tissue compared with control tissue . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The pentapeptide NKISK has been reported to inhibit the binding of decorin , a proteoglycan on the surface of collagen fibrils , to fibronectin , a tissue adhesion molecule . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies against myocilin and other ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , hyaluronic acid , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^ Myocilin predominantly localized in the long spacing collagens and sheath materials surrounding elastic like fibers , codistributed with fibronectin , fibrillin 1 , MAGP 1 , decorin , and type 6 collagen . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry with image analysis was performed to detect the expression of BrdU , alpha SMA , decorin , TGF beta 1 , FN and ColIV in diseased glomeruli . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Microarray data showed that the expression level of fibronectin , decorin sulfate , collagenase , and gelatinase A was upregulated at day 14 in the sponge . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The small proteoglycan decorin plays an important role in the organisation of the extracellular matrix by binding to several components , including collagen and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Total RNA was extracted from the renal biopsy tissue , and mRNA levels of transforming growth factor beta ( TGF beta ) and the extracellular matrix ( ECM ) molecules collagen Ialpha 1 , IIIalpha 1 , IValpha 3 , decorin , fibronectin , and laminin beta 2 were measured by real time polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Both decorin and biglycan including the truncated form of decorin could efficiently bind collagen 1 and fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Both populations produce similar extracellular matrix ( collagen 1 , laminin , fibronectin , decorin ) , except for collagen 4 , which is low in F OST . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In contrast , the expression of several genes that are involved in pericellular matrix formation , including MMP 14 , COL6A1 , fibronectin , biglycan and decorin , was upregulated when the C 20 / A4 cells were transferred to suspension culture in alginate . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin anchorage significantly increased the messenger ribonucleic acid level of decorin , and the messenger ribonucleic acid level of procollagen Type 1 was decreased by matrix anchorage to either fibronectin or Type 1 collagen . ^^^ Transforming growth factor beta 1 increased the messenger ribonucleic acid level of procollagen Type 1 in Type 1 collagen coated plates , but it suppressed the messenger ribonucleic acid level of decorin in fibronectin coated plates . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| RECENT FINDINGS : Histologic studies have revealed that hyaluronic acid , fibronectin , decorin , and various other extracellular matrix components , as well as collagen , may contribute to determining the vibratory properties of the vocal fold mucosa . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| These studies have led to the identification of several mammalian receptors for Lyme disease spirochetes , including glycosaminoglycans , decorin , fibronectin and integrins , as well as a tick receptor for the bacterium , and also candidate cognate bacterial ligands . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| For gene analysis , conventional and quantitative polymerase chain reactions were used for COL1A2 , COL2A1 , aggrecan , BMP 2 , biglycan , decorin , osteonectin , fibromodulin , fibronectin , matrix metalloproteinase 13 ( MMP 13 ) , and tissue inhibitor of MMP 1 . ^^^ Gene expression analysis showed a significant up regulation of COL1A2 , osteonectin , decorin , fibronectin , tissue inhibitor of MMP 1 , BMP 2 , and MMP 13 in compressed discs . ^^^ |
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| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| MMPs are active at neutral pH and can therefore catalyze the normal turnover of extracellular matrix ( ECM ) macromolecules such as the interstitial and basement membrane collagens , proteoglycans such as aggrecan , decorin , biglycan , fibromodulin and versican as well as accessory ECM proteins such as fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| To evaluate extracellular matrix genes , quantitative real time reverse transcriptase polymerase chain reaction was applied for collagen 1 , collagen 2 , biglycan , decorin , fibromodulin , fibronectin , aggrecan , and osteonectin . ^^^ Matrix gene expression was characterized by two major developments : collagen 1 and 2 , biglycan , and decorin showed early elevation followed by later downregulation to control levels , whereas fibromodulin , fibronectin , aggrecan , and osteonectin showed continuous upregulation or remained at similar levels . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| Histologically , both repairs showed strong staining for collagen types 3 and 5 , fibronectin , and decorin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The presence of alpha actin , collagen 1 , decorin , and fibronectin at protein level was demonstrated in TEBVs with and without pulsatile conditions after 6 weeks and in native veins and arteries as well . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| In normal subjects , the jelly like structure of the Reinke ' s space is due to a very loose fibrous scaffolding and to a balance between the interstitial proteins of the ECM : Proteoglycans like decorin and hyaluronic acid and glycoproteins like fibronectin . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| This region has been shown to be rich in proteoglycans ( e . g . , aggrecan , hyaluronan , and decorin ) , collagen ( types 2 , 6 , and 9 ) , and fibronectin , but is defined primarily by the presence of type 6 collagen as compared to the extracellular matrix ( ECM ) . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis revealed the electromagnetically upregulated transcription specific for decorin , fibronectin , osteocalcin , osteopontin , transforming growth factor beta , type 1 collagen , and type 3 collagen . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The EGF receptor is involved in the regulation of cellular proliferation and the synthesis of matrix proteins , and proteoglycan 40 is important for cell attachment and interaction with collagen and fibronectin . 13 cis RA at a concentration of 10 ( 7 ) M markedly reduced the levels of the EGF receptor and PG 40 mRNAs , the decreases being 33 and 56 % , respectively . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| DCN impeded the migration promoting effect of matrix molecules ( fibronectin , collagen type 1 ) known to interact with the proteoglycan . ^^^ In addition , chondroitinase AC treatment of cartilage DCN ( which specifically removes chondroitin sulfate chains ) did not attenuate the inhibitory effect of this proteoglycan , while cartilage DCN deprived of both chondroitin and dermatan sulfate chains failed to alter cell migration promoted by either fibronectin or its heparin and cell binding domains . ^^^ However , isolated glycosaminoglycans failed to alter cell migration promoted by fibronectin , indicating that strongly negatively charged glycosaminoglycans alone can not account for the impaired cell motility seen with DCN . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| No evidence was found for a role for fn , the proteoglycan PG 2 or collagen type 5 , which could be present in type 1 fibres , in mediating the interaction between tsp and the fibres . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| The effect of several extracellular matrix components on glucose metabolism was assessed by incubating A 431 cells and NIH3T3 fibroblasts with heparin , laminin , fibronectin , collagen and PG 1 and PG 2 proteoglycans and measuring the levels of Fru 2 , 6 P 2 . ^^^ |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07585 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|