| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition to plasma protein related forms such as transferrin , lactoferrin , and fibronectin , specific proteins such as semenogelin ( 52 kDa ) are synthesized , the scaffold protein of semen coagulate forming the substrate for PSA ( prostate specific antigen ) , sperm motility inhibitor ( ca . 18 kDa ) , and others ( placental protein 5 , protein kinase inhibitor , carboanhydrase , 5 ' nucleotidase ) , some of which are immunosuppressive . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Both the gel bound fibronectin and semenogelin are progressively fragmented and solubilized by the abundant prostatic kallikrein like protease ( prostate specific antigen ) during and after seminal gel liquefaction . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| In order to determine the patterns of hydrolysis of major seminal vesicle proteins , semenogelins and fibronectin were exposed to hK 2 and to hK 3 ( prostate specific antigen or PSA ) and cleavage sequences were identified by N terminal sequencing . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| The cellular responses of a newly established and early passage human prostate adenocarcinoma cell line , MDA PCa2a , to transforming growth factor ( TGF ) beta 1 , epidermal growth factor ( EGF ) , and TGFalpha were characterized in terms of proliferation , production of prostate specific antigen ( PSA ) , fibronectin ( FN ) and laminin ( LM ) . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunostains of BK 10 were negative for prostate specific antigen ( PSA ) , fibronectin , smooth muscle actin alpha , and desmin . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Prostate specific antigen ( PSA ) is a well established marker of prostate cancer , but it can also degrade extracellular matrix proteins such as fibronectin and could be involved in tumor progression and metastasis . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Here PrECs were characterized for the expression of lineage and developmental specific markers cytokeratin ( CK ) 8 and 18 , p 63 , chromogranin A , TMEPAI , S100P , NKX 3 . 1 , ANKH , and FN 1 as well as androgen receptor and prostate specific antigen by Western blot and Northern blot analyses , immunohistochemistry , reverse transcriptase polymerase chain reaction ( RT PCR ) , and quantitative real time PCR . ^^^ RT PCR with PrEC cDNA showed products for FN 1 and S100P but not for ANKH and androgen receptor or prostate specific antigen . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| However , we demonstrated that these two parameters do not appear to depend on high PSA N CAM molecules when cells were grown on a fibronectin substratum , indicating the existence of a hierarchy among adhesion molecules . . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| PSA is mainly responsible for gel dissolution in freshly ejaculated semen by proteolysis of the major gel forming proteins semenogelin 1 and 2 and fibronectin . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| PSA is mainly responsible for gel dissolution in freshly ejaculated semen by proteolysis of the major gel forming proteins , semenogelin 1 and 2 , and fibronectin . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Functionally and structurally PSA is a kallikrein like serine protease , and its physiologic role is degradation of the major proteins of seminal coagulum ( semenogelin 1 and 2 , fibronectin ) , which leads to semen liquefaction . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Concentrations of IGF 1 and alpha 2 M in human seminal plasma were related to semen quality , basal concentrations of HGH , testosterone , IGFBP 3 , soluble fibronectin receptor ( sFNR ) , PSA and PP 14 in seminal plasma and to serum concentrations of luteinizing hormone ( LH ) and follicle stimulating hormone ( FSH ) . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that PSA degrades extracellular matrix glycoproteins fibronectin and laminin and , thus , may facilitate invasion by prostate cancer cells . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Recently , hK 2 was shown to activate the zymogen form of PSA ( proPSA ) in vitro and is likely to be the physiological activator of PSA in the prostate . hK 2 is also able to activate urokinase and effectively cleave fibronectin . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| PSA is a serine protease with substrates that include semenogelin 1 and 2 , insulin like growth factor binding protein 3 , fibronectin , and laminin . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Also , by Western blot we have followed the degradation of fibronectin by enzymatically active PSA and have found significant inhibition in the presence of boric acid . ^^^ |
|
| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| We compared areal bone mineral density ( BMD ) of the total body ( TBMD ) , antero posterior lumbar spine at L 3 ( APS ) , lateral spine at L 3 ( LS ) and femoral neck ( FN ) . ^^^ Results of the statistical analyses ( ANOVA ) showed the men to have significantly greater BMD at all areal sites [ APS , LS ( p < 0 . 05 ) ; FN ( p < 0 . 01 ) ; TBMD ( p < 0 . 001 ) ] . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| When cells were cultured on these materials in serum containing medium , formation of FN receptor rich focal adhesions and actin stress fibers were more evident on the hydrophilic surfaces ( GLASS and APS ) compared to the hydrophobic ones ( PL , ODS , and SI ) . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopy revealed increased stress formation and fibronectin ( FN ) receptor rich focal adhesions for fibroblasts attached on more hydrophilic surfaces ( glass and APS ) in comparison to the relatively hydrophobic materials ( ODS and SI ) . ^^^ Phosphorylation of tyrosine residues , also studied by immunofluorescence microscopy , was considerably higher on glass and APS , lower for ODS , negligible for SI , and was found to colocalize with FN receptor rich focal adhesions . ^^^ |
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| Interacting proteins: P07288 and P02751 |
Pubmed |
SVM Score :0.0 |
| Moreover , fibrillar organization of fibronectin appeared only on relatively hydrophilic glass and APS substrate , while on more hydrophobic materials like PVC and SI , cells secreted some fibronectin but were not able to organize it into a fibronectin matrix . ^^^ |
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