| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :1.1270015 |
| Inhibition of interactions between FN and integrin alpha 5 beta 1 by the competitive GRGDSP peptide or anti alpha 5 integrin antibody restricted cell spreading , reduced cell surface staining for alpha 5 beta 1 and FN fibrils , and inhibited PDGF BB induced DNA synthesis . 1.1270015^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.83264617 |
| These findings indicate that integrin alpha 5 is rapidly expressed on GC during luteinization , probably under LH stimulation , and suggest that integrin alpha 5 is involved in CL formation via interaction with its ligand FN . . 0.83264617^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Characterization of the integrin alpha 5 beta 6 as a fibronectin binding protein . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 beta 1 is a heterodimeric fibronectin receptor . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Antibody mAb 16 , which recognizes the integrin alpha 5 subunit , partially blocked binding of 125I fibronectin and 125I 70 kD . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic domain of the integrin alpha 5 subunit was required for the alpha 5 beta 1 mediated cell survival on fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Regulation of integrin alpha 5 beta 1 fibronectin interactions by divalent cations . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Affinity modulation of integrin alpha 5 beta 1 : regulation of the functional response by soluble fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The expression of integrin alpha 5 beta1 and fibronectin was found to be increased transiently during chondrogenesis . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The cation binding domain from the alpha subunit of integrin alpha 5 beta1 is a minimal domain for fibronectin recognition . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of fibronectin receptor , integrin alpha 5 beta 1 of hepatic stellate cells in rat liver fibrosis . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Their formation is heavily dependent on interactions between integrin alpha 5 beta 1 and fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The fibronectin receptor , alpha subunit ( Itga 5 ) maps to murine chromosome 15 , distal to D15Mit16 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| To explore this issue , we previously selected a series of CHO variants that are deficient in expression of the integrin alpha 5 beta 1 , the `` classical ' ' fibronectin receptor . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The surface expression of fibronectin and its major integrin receptor in liver , integrin alpha 5 beta 1 , was studied during liver regeneration after partial hepatectomy . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Complete inhibition of adhesion to fibronectin was observed with anti beta 1 antibody , and partial inhibition with anti alpha 5 , suggesting that integrin alpha 5 beta 1 is mainly responsible for the interaction . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We have studied the interactions , over several hours , of adult rat hepatocytes with fibronectin substrata in vitro by interference reflection microscopy and by laser scanning confocal immunomicroscopy using antisera against the fibronectin receptors , integrin alpha 5 beta 1 and nonintegrin Agp 110 , together with phalloidin , a specific marker for filamentous actin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin and the fibronectin receptor , integrin alpha 5 beta 1 , were distributed pericellularly and expressed at a steady level during development from the 16th day of gestation and in neonate and adult liver . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of fibronectin , the integrin alpha 5 , and alpha smooth muscle actin in heart and lung development . ^^^ We examined the distribution of FN and the alpha 5 subunit of its receptor , the integrin alpha 5 beta 1 , in the lungs and hearts of murine embryos at 11 , 13 , 16 , and 18 days of gestation . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Insoluble fibronectin activates the Na / H antiporter by clustering and immobilizing integrin alpha 5 beta 1 , independent of cell shape . ^^^ We now show that insoluble fibronectin activates the Na / H antiporter by clustering and immobilizing integrin alpha 5 beta 1 , independent of effects on cell shape . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| This structural difference apparently results in a functional distinction , since purified alpha 5 beta 3 bound to vitronectin , fibrinogen , von Willebrand factor , and fibronectin , whereas integrin alpha 5 beta 5 bound preferentially to vitronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Previous work has shown that adhesion of anchorage dependent cells to fibronectin via integrin alpha 5 beta 1 leads to activation of the Na H antiporter and a rise in intracellular pH ( pHi ) . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Vitronectin receptor antiserum specific for integrin alpha 5 beta 3 blocked cell adhesion and spreading on substrates containing 100 fmol / cm2 of surface bound GRGDY , while fibronectin receptor antiserum specific for alpha 5 beta 1 did not . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Distribution of fibronectin and fibronectin binding proteins , AGp 110 and integrin alpha 5 beta 1 , during chemically induced hepatocarcinogenesis in adult rats . ^^^ We have used single and double label immunocytochemistry to examine the distribution of AGp 110 , integrin alpha 5 beta 1 and fibronectin in adult rat liver during carcinogenesis induced by aflatoxin B 1 or diethylnitrosamine . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| This laminin binding integrin did not bind to Sepharose conjugated with a 105 kDa cell binding fragment of fibronectin and conversely , the fibronectin receptor of the cells ( integrin alpha 5 beta 1 ) did not bind to the laminin Sepharose . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| When human fibroblasts were cultured on fibronectin for 4 h in the presence of 0 . 5 mg / ml of the GRGDSP peptide derived from the fibronectin cell binding site , they adhered and spread normally and organized talin and integrin alpha 5 and beta 1 subunits into focal adhesions . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Transformation of rat 1 , NRK , and Nil 8 cells by Rous sarcoma virus or by murine sarcoma viruses encoding ras oncogenes leads to reductions in the level of integrin alpha 5 beta 1 , which is a well defined fibronectin receptor , and of two other integrin receptors . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We analyzed the binding of fibronectin to integrin alpha 5 beta 1 in various cells ; in some cells fibronectin bound with low affinity ( e . g . , K 562 cells ) whereas in others ( e . g . , CHO ) , it bound with high affinity ( Kd approximately 100 nM ) in an energy dependent manner . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of integrin alpha 5 beta 1 ( fibronectin receptor ) of mouse peritoneal macrophages in vitro : an immunoelectron microscopic study . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The interaction between the central cell binding domain ( CBD ) of fibronectin ( FN ) and its receptor integrin alpha 5 beta 1 was analyzed by both ligand binding and cell adhesion assays . ^^^ The present study suggests that the alpha 5 subunit does not participate in direct binding to the Arg Gly Asp site in CBD when cells adhere to FN through the integrin alpha 5 beta 1 , but that it is involved in the interaction with the synergistic regions of CBD , which then enhances the binding of the beta 1 subunit to the Arg Gly Asp sequence containing CBD . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Synchronous appearance of fibronectin , integrin alpha 5 beta 1 , vinculin and actin in epithelial cells and fibroblasts during rat tracheal wound healing . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 5 beta 3 binds promiscuously to cell adhesive proteins : vitronectin , fibronectin , and several others containing the RGD motif . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Consequently , we have used this model system to study the effects of repression of autocrine TGF beta 1 activity on the expression of integrin alpha 5 beta 1 and integrin alpha 5 beta 1 mediated cell adhesion to fibronectin . ^^^ The diminished expression of integrin alpha 5 beta 1 on the cell surface led to the reduced adhesion of TGF beta 1 antisense transfected cells to fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| To examine whether IL 6 promotes cell attachment through up regulation of expression of integrin alpha 5 beta 1 , i . e . , the major cell surface fibronectin receptor , we quantified the levels of both alpha 5 and beta 1 subunit transcripts by reverse transcription polymerase chain reaction in cultured rabbit corneal epithelial cells pretreated with various concentrations of IL 6 . ^^^ These results indicate that the increased attachment of corneal epithelial cells to fibronectin and enhanced ex vivo migration on corneal stroma by IL 6 is , at least in part , due to the temporal up regulation of integrin alpha 5 beta 1 expression in corneal epithelial cells . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Requirement for the synergy site for cell adhesion to fibronectin depends on the activation state of integrin alpha 5 beta 1 . ^^^ We investigated the influence of the activation state of integrin alpha 5 beta 1 on its dependence on the PHSRN synergy site for binding to RGD in fibronectin . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 beta 1 expression negatively regulates cell growth : reversal by attachment to fibronectin . ^^^ These findings demonstrate that integrin alpha 5 beta 1 expression in the absence of attachment to fibronectin activates a signaling pathway leading to decreased cellular proliferation and that ligation of this receptor with fibronectin reverses this signal , thereby contributing to the proliferation of transformed cells . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The increased integrin alpha 5 beta 1 appears to function by reducing mitogenic activity since blockade of fibronectin binding to its receptor with a RGD peptide , a monoclonal anti fibronectin antibody , or a monoclonal anti alpha 5 subunit antibody during the release from quiescence significantly stimulated DNA synthesis . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Tissue specimens were collected at different times after injury and stained with antibodies against subunits of the fibronectin receptor , integrin alpha 5 beta 1 , and the vitronectin receptor , integrin alpha 5 beta 5 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 5 beta 6 is expressed primarily in epithelial cells and mediates attachment to the extracellular matrix protein fibronectin . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Role of the integrin alpha 5 beta 6 in cell attachment to fibronectin . ^^^ The integrin alpha 5 beta 6 has been shown to be a fibronectin binding protein . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| However , functionally blocking antisera directed against the vitronectin receptor , integrin alpha 5 beta 3 , and the fibronectin receptor , integrin alpha 5 beta 1 , did not affect HFF spreading on these substrates . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Because fibulin co distributes with both FN and the FN receptor , the integrin alpha 5 beta 1 , we examined the possibility that fibulin was interacting with both components . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Purified FN , antibodies to the integrin alpha 5 beta 1 ( FN receptor on human placenta ) , and antibodies specific for the integrin beta 1 subunit recognized a C . tropicalis membrane protein of 125 + / 25 kDa on immunoblots . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Alendronate inhibited the cAMP increase induced by ligands that primarily utilize integrin alpha nu beta 3 ( vitronectin , Peptite 2000 ) , but not by fibronectin which can also use integrin alpha 5 beta 1 . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Our data indicated that , while talin , vinculin , paxillin , fibronectin receptor and integrin beta 1 were present at the three stress fiber membrane association sites , vitronectin receptor and integrin alpha 5 were absent from the apical plaque and the lateral association site . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 beta 1 clustering was changed in the sites of focal contacts , most probably representing its relocalization as a consequence of the increased amounts of fibronectin . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 beta 1 / alpha 5 beta 3 mediated adhesion to fibronectin , CD 44 mediated adhesion to hyaluronate , and E cadherin / beta 1 integrin mediated adhesion to keratinocytes were not affected by PMA . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Intrablastocoelic injections of several probes including antibodies to FN or integrin alpha 5 beta 1 , competitive peptides to the major cell binding site of FN or the antiadhesive protein tenascin all block mesodermal cell migration . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| This inhibitory effect of the P 3 peptide seems to be specific for alpha 6 beta 1 , since it did not affect the binding of fibronectin to integrin alpha 5 beta 1 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Identification of a new biological function for the integrin alpha 5 beta 3 : initiation of fibronectin matrix assembly . ^^^ Although the integrin alpha 5 beta 1 has been implicated in the assembly of fibronectin matrices , fibroblastic cells derived from alpha 5 integrin null mutant embryos assemble a fibronectin matrix . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 5 beta1 mediated fibronectin adhesion , demonstrating for the first time the existence of a functionally active beta 1 integrin on mouse PMN . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The relatively high expression of integrin alpha 5 beta 1 in Group 1 cell lines resulted in strong enhancement of cell adhesion to fibronectin ( FN ) tissue culture plates , whereas Group 3 cell lines showed little or no enhancement of cell adhesion by coating . ^^^ Cell adhesion to FN in Group 1 cells was mainly mediated by integrin alpha 5 beta 1 because a monoclonal anti alpha 5 subunit antibody could block cell adhesion to FN , whereas anti alpha 2 and anti alpha 3 antibodies had no effect on cell adhesion to FN . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical staining showed that fibronectin was detected in the extracellular matrix ( and partially on the surface of tumor cells ) , integrin alpha 5 beta 1 on the cell surface , and vinculin and actin were detected in the cytoplasm of the tumor cells . ^^^ We conclude that the expression of fibronectin , integrin alpha 5 beta 1 , vinculin , cytoplasmic actin and fibronexus like structure in leukemic cells indicate these cells possess an adhesive function . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The degree of expression of the integrin alpha 5 subunit correlated well with the strength of glioma cell adhesion to fibronectin rather than that of migration to the molecule . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The cell spreading activity of EDA+ FN was not affected by antibodies recognizing the EDA segment but was abolished by antibodies against integrin alpha 5 and beta 1 subunits and by Gly Arg Gly Asp Ser Pro peptide , indicating that the EDA segment enhanced the cell adhesive activity of FN by potentiating the interaction of FN with integrin alpha5beta1 . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We report that disruption of ligation between alpha 5 alpha 1 and fibronectin by integrin alpha 5 subunit or fibronectin monoclonal antibodies stimulated DNA synthesis in growth arrested FET human colon carcinoma cells . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| To clarify the mechanisms by which substance P ( SP ) and insulin like growth factor 1 ( IGF 1 ) synergistically facilitate corneal epithelial wound healing , we tested the hypothesis that the combination promotes cell attachment to a fibronectin matrix through up regulation of expression of integrin alpha 5 beta 1 , the major cell surface fibronectin receptor in rabbit corneal epithelial cells . ^^^ The combination of SP and IGF 1 significantly increased the number of cells attached to the fibronectin matrix and the expression of integrin alpha 5 . ^^^ Thus , the synergistic enhancing effect of SP and IGF 1 on the attachment of corneal epithelial cells to the fibronectin matrix and on corneal epithelial migration is partly due to the up regulation of integrin alpha 5 expression in corneal epithelial cells . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of transforming growth factor beta 1 ( TGF beta 1 ) , the only known inducer of CTGF so far , as well as of the CTGF target genes collagen 1 alpha 1 , fibronectin and integrin alpha 5 revealed a strong correlation with the expression of CTGF . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Arg Arg Glu Thr Ala Trp Ala ( RRETAWA ) is a novel ligand peptide for integrin alpha 5 beta1 , which blocks alpha 5 beta1 mediated cell adhesion to fibronectin ( Koivunen , E . , Wang , B . , and Ruoslahti , E . ( 1994 ) J . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Binding to immobilized anti CD 44 antibody induced a monolayer morphology which is accompanied by fibronectin production and secretion , and expression of the integrin alpha 5 beta 6 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The combination of both FGLM and IGF 1 and substance P and IGF 1 significantly increased the number of cells adhered to the fibronectin matrix and the expression of integrin alpha 5 . ^^^ The synergistic effect of FGLM and IGF 1 on the adhesion of HCE cells to the fibronectin matrix is partly carried through up regulation of integrin alpha 5 expression in HCE cells . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression and detection of integrin alpha 5 beta 1 , fibronectin and its fragment in patients with hepatocellular carcinoma ] . ^^^ OBJECTIVE : To study the relationship between the expression of integrin alpha 5 beta 1 , fibronectin ( FN ) and its fragment ( malignant disease associated DNA binding protein 2 MAD 2 ) and the biologic behavior of human hepatocellular carcinoma HCC ) as well as the significance of MAD 2 detection in plasma . ^^^ METHODS : Integrin alpha 5 beta 1 , FN and MAD 2 were localized by immunohistochemical methods and quantified by image analysis in tumor and peripheral liver tissues from 40 HCC cases . ^^^ RESULTS : The expression of integrin alpha 5 beta 1 , FN and MAD 2 in well differentiated HCC were not significantly different from that of normal tissues , while they were markedly decreased or undetectable in mode rately and poorly differentiated HCC . ^^^ Decreased expression of integrin alpha 5 beta 1 and FN at sites where HCC invaded the connective tissue and enhanced expression on the HCC cells around cancerous emboli were also noted . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| This suppressive effect was accompanied by down regulation of alpha smooth muscle actin , EDA spliced form of fibronectin , and integrin alpha 5 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The association of fascin with actin in fibronectin adherent cells was also evident in the presence of an inhibitory antibody to integrin alpha 5 subunit . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Human Tenon ' s capsule fibroblasts were cultured into 96 well plates and treated with different concentrations ( ranging from 10 ( 6 ) to 1 microg ml ( 1 ) ) of three different integrin antibodies : human integrin alpha 2 antibody , human integrin alpha 3 antibody and human integrin alpha 5 / FnR ( fibronectin receptor ) antibody . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| On uncoated or fibronectin coated plastic , the integrin alpha 5 and control ( vector only ) transfectants grew at similar rates . ^^^ However , when cultured on fibronectin , the integrin alpha 5 transfectants were not growth inhibited by mAb 225 . ^^^ The reversal of mAb 225 mediated growth inhibition on fibronectin for the integrin alpha 5 transfectants correlated with activation of the EGFR , activation of MAPK , and expression of proliferating cell nuclear antigen . ^^^ Although EGFR activation occurred when either the integrin alpha 5 transfected or control cells were cultured on fibronectin , coprecipitation of the EGFR with SHC could be demonstrated only in the integrin alpha 5 transfected cells . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Column stability is dependent on the interaction between extracellular fibronectin and integrin alpha 5 beta 1 expressed at the cell surface , both of which are upregulated in this pathway . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of integrin alpha 5 , beta 1 subunit and fibronectin mRNAs in human hepatocellular carcinoma ] . ^^^ OBJECTIVE : To study the biologic significance of the expression of integrin alpha 5 , beta 1 subunit and fibronectin ( FN ) mRNAs in hepatocellular carcinoma ( HCC ) . ^^^ METHODS : Integrin alpha 5 , beta 1 subunit and FN mRNAs were detected by using Northern blot ( alpha 32P labeled cDNA probes ) and in situ hybridization ( Dig labeled cDNA probes ) in 15 cases of HCC , 5 cases of paracancerous cirrhotic liver and 3 cases of normal liver tissue . ^^^ RESULTS : In well differentiated HCC , the level of integrin alpha 5 , beta 1 or FN mRNA expression was similar to those in normal liver and paracancerous cirrhotic liver tissues , but was markedly decreased , even absent in the poorly and moderately differentiated HCC tissues ( P < 0 . 01 , respectively ) . ^^^ The expression of integrin alpha 5 and FN mRNAs was mainly detected in the cytoplasm of HCC cells . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 5 beta 6 is a fibronectin receptor that is undetectable on normal keratinocytes in situ , but is increased significantly in wound healing and in culture established keratinocytes , suggesting that it may promote changes associated with cell motility . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the ECM regulates the induction of ALP expression by AsA in fibroblasts : FN enables them to express ALP in response to AsA through interaction with integrin alpha 5 beta 1 , whereas type 1 collagen fibrils cause the suppression of ALP expression and overcome FN . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative form of Ets 1 suppresses fibronectin stimulated cell adhesion and migration through down regulation of integrin alpha 5 expression in U 251 glioma cell line . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The production of basement membrane molecules such as collagen type 4 and several laminins , the interstitial molecules fibronectin and tenascin C , and the cell surface molecules integrin alpha 5 and alpha 6 were quantitated in vitro using ELISA on cultured cells from MyoD ( / ) and wild type mice . ^^^ Differences were observed in the production of fibronectin , tenascin C , collagen type 4 , laminin 1 and integrin alpha 5 between control and MyoD ( / ) myotubes in vitro . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Like the 24 K fragment , a peptide from the 14th type 3 repeat , termed FNIII 14 , which suppressed the integrin alpha 5 beta 1 mediated adhesion of ST 13 cells to FN , accelerated the adipocyte differentiation by preventing FN fibrillogenesis without direct incorporation into the FN matrix . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We used cell adhesion assay to estimate the affinity of alpha 5 beta 1 integrin with fibronectin , and analyzed the amount of integrin alpha 5 and beta 1 subunits by performing FACS analysis . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Cell adhesion to extracellular matrix proteins such as poly L lysine and fibronectin was mediated by H . pylori induced expression of integrin alpha 5 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 5 and beta 1 were strongly expressed in all groups , but integrin alpha 1 was strongly expressed only in collagen type 1 and fibronectin conjugated alginate beads , and integrin alpha 2 was strongly expressed only in collagen type 2 conjugated alginate beads . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We have used solution 10 ray scattering to visualize the head region of integrin alpha 5 beta 1 in an inactive ( Ca2+ occupied ) state , and in complex with a fragment of fibronectin containing the RGD and synergy recognition sequences . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The formation of stress fibers and the localization of integrin alpha 5 and beta 1 chains ( which together form a fibronectin receptor ) in bovine TM cells were investigated by laser confocal microscopy of cells stained with phalloidin and antibodies to the integrin subunits . ^^^ Furthermore , fibronectin induced the spreading of cells , the formation of actin stress fibers , and the expression of integrin alpha 5 in the collagen gel embedded TM cells . ^^^ Moreover , the formation of actin stress fibers and upregulation of integrin alpha 5 appear to contribute to this permissive effect of fibronectin . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Tissue RNA levels of fibronectin and integrin alpha 5 were significantly higher in the hypoxic condition than under normoxic conditions . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| In contrast , blocking of integrin alpha 5 and beta 1 suppressed adhesion and migration on full length Fn and the 110 kDa Fn fragment . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Syndecan 2 cooperates with integrin alpha 5 beta 1 in cell adhesion to a fibronectin substratum and regulates actin cytoskeletal organization in an expression level dependent manner ; Lewis lung carcinoma derived P 29 cells with high expression form stress fibers , whereas the same tumor derived low expressers , LM 66 H11 cells , form cortex actin [ Munesue , S . , Kusano , Y . , Oguri , K . , Itano , N . , Yoshitomi , Y . , Nakanishi , H . , Yamashina , I . , and Okayama , M . ( 2002 ) BIOCHEM : J . 363 , 201 209 ] . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| In Raldh 2 ( / ) embryos , there was down regulation of TGF beta 1 , fibronectin ( Fn ) and integrin alpha 5 , which was associated with decreased visceral endoderm survival and production of VEGF A , Indian hedgehog ( IHH ) , and bFGF . ^^^ Exogenous provision of RA or Fn to Raldh 2 ( / ) explants in whole mouse embryo culture restored vascular remodeling , visceral endoderm survival , as well as integrin alpha 5 expression and its downstream signaling that controls endothelial growth . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that invasion of human brain microvascular endothelial cells ( HBMEC ) by meningococci is mediated by bacterial outer membrane protein Opc that binds fibronectin , thereby anchoring the bacterium to the integrin alpha 5 beta 1 receptor on the endothelial cell surface . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Gene expression profiling of MMA 2 revealed a set of genes upregulated by the EP 2 agonist , including several growth promoting and apoptosis protecting genes such as the cyclin D 1 , fibronectin , integrin alpha 5 , AP2alpha , and 14 3 3gamma genes . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Our observations unveil a new mechanism of action against NSCLC for COX 2 inhibitors that relates to regulation of integrin alpha 5 gene expression and , consequently , recognition of extracellular matrices ( i . e . , fibronectin ) by tumor cells . ( c ) 2005 Wiley Liss , Inc . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , TNF alpha induced metastatic properties including adhesion to fibronectin , mRNA expression of integrin alpha 5 , production of matrix metalloproteinase 9 and invasion were inhibited by gefitinib without affecting cell proliferation . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of integrin alpha 5 , a counter adhesion molecule for fibronectin , was inhibited by the treatment with PPARgamma antagonists . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Expression of integrin alpha 5 and integrin beta 4 and their extracellular ligands fibronectin and laminin in human decidua during early pregnancy and its sex steroid mediated regulation . ^^^ The present study aimed to investigate distribution patterns , staining intensity and sex steroid mediated regulation of integrin alpha 5 ( CD49e ) , integrin beta 4 ( CD49f ) expression and their ligands fibronectin and laminin during decidualization . ^^^ Correlating immunostaining was found between laminin and integrin beta 4 , and between fibronectin and integrin alpha 5 . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Increased expression of genes encoding proteins involved in GAS host cell adherence and internalization ( fibronectin , integrin alpha 5 ) was found as a common response . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Based on these data , we hypothesize that fucoidan inhibits the adhesion of MDA MB 231 cells to fibronectin 1 ) by blocking the protein ' s heparin and cell binding domains , 2 ) by modulating the reorganization of the integrin alpha 5 subunit and 3 ) by down regulating the expression of vinculin . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that mEMAP 2 blocks MEC adhesion and spreading on fibronectin , via a direct interaction with the integrin alpha 5 beta1 , thus implicating that alpha 5 integrin may be a mediator of mEMAP 2 ' s antiangiogenic function . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression indexes of integrin alpha 5 and beta 1 on K 562 cells , the binding capability of K 562 cells to fibronectin ( FN ) , and K 562 cell FN binding blocking induced by integrin alpha 5 and beta 1 antibodies were evaluated by flow cytometry ( FCM ) . ^^^ IFNalpha 2b could not change the expression of integrin alpha 5 and beta 1 on K 562 cells , but improved the binding capability of K 562 cells to FN , which could be blocked by anti alpha 5 and / or anti beta 1 antibodies . ^^^ CONCLUSION : IFNalpha 2b could inhibit the proliferation of K 562 cells through restoring the function of integrin alpha 5 and beta 1 , enhancing binding capability of integrin alpha 5 and beta 1 to FN , and up regulating FAK gene expression . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| The SHG 44 cells transfected with antisense cDNA of GalT 5 demonstrated decreased Golgi localization of integrin beta 1 , strengthened the interaction between integrin alpha 5 and beta 1 subunit , and enhanced the adhesion ability to fibronectin and the level of focal adhesion kinase phosphorylation . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , a remarkable induction was detected in the genes for syndecan 4 ( SDC 4 ) and alpha 5 integrin ( ITGA 5 ) , the cell adhesion molecules involved in the enhanced adhesion of cancer cells to fibronectin . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| By a genetic screening procedure with zebrafish , we identified two genes , integrinalpha 5 ( itga 5 ) and fibronectin ( fn ) , required for these processes . ^^^ Both Fibronectin accumulation and the epithelialization are dependent on itga 5 , which is expressed in the most medial part of somites . ^^^ Furthermore , with an additional deficiency in ephrin B2a , the segmental defect in itga 5 or fn mutant embryos is expanded posteriorly , indicating that both Integrin Fibronectin and Eph Ephrin systems function cooperatively in maintaining somite boundaries . . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Confirmation of the assignment of the vitronectin ( VNRA ) and fibronectin ( FNRA ) receptor alpha subunits . ^^^ Using human rodent somatic cell hybrids and cDNA probes corresponding to the alpha subunits , we have confirmed the mapping of the fibronectin receptor ( FNRA ) to chromosome 12 and the vitronectin receptor ( VNRA ) to chromosome 2 . . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Basement membrane proteins , laminin , and collagen type 4 , as well as vitronectin and fibronectin , were identified in the intima and there was corresponding expression of integrin and non integrin receptors ( e . g . , CD 29 , CD49b , CD49d , CD49e , CD49f , CD 51 , CD 61 , CD 44 ) for these matrix proteins . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition , a much weaker expression of the second fibronectin receptor VLA 5 , the laminin receptor VLA 6 and the vitronectin receptor CD 51 was demonstrated . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| HTSC express CD 54 ( ICAM 1 ) , CD49a ( VLA 1 ) , CD49b ( VLA 2 ) , CD49c ( VLA 3 ) , CD49e ( VLA 5 ) , CD49f ( VLA 6 ) , CD 29 , CD 51 , CD 44 and produce vinculin , beta tubulin , alpha actin , vimentin , fibronectin , laminin and collagen types 1 , 3 and 4 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| Spermatozoa were incubated with antibodies against alpha 1 ( CD49a ) , alpha 2 ( CD49b ) , alpha 3 ( CD49c ) , alpha 4 ( CD49d ) , alpha 5 ( CD49e ) , alpha 6 ( CD49f ) chains of beta 1 integrins , beta 1 ( CD 29 ) , beta 2 ( CD 18 ) , alpha 5 ( CD 51 ) , beta 3 ( CD 61 ) and beta 4 integrin chains , the LFA 3 ( Lymphocyte function antigen , CD 58 ) from the immunoglobulin superfamily and the extra cellular matrix proteins laminin , fibronectin and collagen 4 . ^^^ |
|
| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We sought to determine whether expression of CD 51 ( vitronectin and fibronectin receptor ) , CD 54 ( intercellular adhesion molecule 1 ) , HLA DR ( activation marker ) , CD 29 ( beta 1 integrin ) , CD49b ( collagen receptor ) , and CD11b ( complement receptor ) exhibit a circadian rhythm in asthma . ^^^ |
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| Interacting proteins: P06756 and P02751 |
Pubmed |
SVM Score :0.0 |
| We analyzed the constitutive and transforming growth factor ( TGF ) beta induced expression of the adhesion molecules CD 44 , CD49b , CD49c , CD 51 , CD 54 , and CD 61 and extracellular matrix ( ECM ) components fibronectin , laminin and collagen 4 . ^^^ |
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