| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The adhesion structures for fibronectin and collagen were shown to be members of the CD 29 integrin family . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Lymphocytes adhere to fibronectin ( FN ) via multiple receptors of the VLA ( beta 1 , CD 29 integrin ) family . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In vivo analyses of integrin beta 1 subunit function in fibronectin matrix assembly . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The increase in the cell surface beta 1 integrins resulted in a stronger binding of the IL 1 beta treated cells to fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Evidence for a beta 1 integrin fibronectin receptor in Candida tropicalis . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Integrin linked protein kinase regulates fibronectin matrix assembly , E cadherin expression , and tumorigenicity . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Activin also induced extracellular matrix proteins fibronectin and integrin beta 1 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha8beta1 binds to several ligands such as fibronectin and vitronectin through the RGD sequence . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Intracellular tyrosin phosphorylation induced by fibronectin by CD 29 stimulation in H 9 cells was analyzed by immunoblotting . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Activation of TLR 3 on huMC resulted in a change in the conformation of CD 29 , the receptor for FN , to an inactive form . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Wild type and mutant chicken integrin beta 1 subunit ( beta 1c ) cDNAs were expressed in NIH 3T3 cells and assayed for localization in focal adhesions of cells plated on fibronectin substrates . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Here we report that beta 1 containing integrins are , nevertheless , the principal fibronectin receptors in the Xenopus gastrula , although their cell surface levels are low . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques . ^^^ A point mutation in a highly conserved region of the beta 1 subunit , Asp 130 to Ala ( D130A ) substitution , abrogates the Arg Gly Asp ( RGD ) dependent binding of alpha 5 beta 1 to fibronectin ( FN ) without disrupting gross structure or heterodimer assembly . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Basement membrane proteins , laminin , and collagen type 4 , as well as vitronectin and fibronectin , were identified in the intima and there was corresponding expression of integrin and non integrin receptors ( e . g . , CD 29 , CD49b , CD49d , CD49e , CD49f , CD 51 , CD 61 , CD 44 ) for these matrix proteins . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Fibroblasts spread within 1h on substrata composed of fibronectin and formed focal adhesions by 3h , as monitored by interference reflection microscopy ( IRM ) and by labeling for talin , vinculin and integrin beta 1 subunits . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In addition , anti CD 29 ( integrin beta 1 ) as well as anti VLA 5 ( human fibronectin receptor ) antibodies blocked this CD 4 cell activation in this system . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The DNA markers , RBP 3 ( retinol binding protein 3 , interstitial ) and FNRB ( fibronectin receptor , beta polypeptide ) , are both tightly linked to the MEN2A locus , and are localized to opposite sides of the MEN2A locus . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The 120 kDa band reacted with antibodies to beta 1 in immunoblotting experiments . 293 cells adhere to vitronectin , fibronectin , laminin , and collagen 4 , while von Willebrand factor and fibrinogen , known ligands of the VnR ( alpha v . beta 3 ) , did not support adhesion . ^^^ A beta 1 specific monoclonal inhibited attachment to fibronectin , laminin , and collagen 4 , known ligands of beta 1 integrins , as well as vitronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Enhancement of anti CD 3 induced proliferation by immobilized fibronectin was completely inhibited by a mAb to CD 29 , the integrin beta 1 chain ( 4B4 ) and not by a variety of other mAb . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Migration of neural crest cells depends on direct , transient interactions between fibronectin molecules and their corresponding Arg Gly Asp integrin receptors . ^^^ We have previously suggested that the moderate activity interaction between integrin receptors and fibronectin may be critical for the transient association of the cells with their substratum . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Fibronectin / integrin interaction induces tyrosine phosphorylation of a 120 kDa protein . ^^^ The protein appears to be located in focal contacts where it codistributes with beta 1 integrins . pp 120 is distinct from the beta 1 subunit of integrins and from vinculin and alpha actinin . pp 120 is rapidly dephosphorylated in cells suspended by trypsinization but becomes rapidly phosphorylated in cells attaching and spreading on fibronectin . ^^^ Thus interaction of beta 1 integrins with extracellular ligands ( fibronectin or antibodies ) triggers phosphorylation of an intracellular 120 kDa protein , pp 120 , that may be involved in the responses of cells to attachment . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Furthermore , CFU S 12 stem cells express the alpha 4 subunit of the VLA 4 integrin receptor , which is known to be a receptor for the CS 1 sequence , and monoclonal antibodies against the integrin alpha 4 subunit of VLA 4 block adhesion of CFU S 12 stem cells to plates coated with the C terminal fibronectin fragment . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| A cDNA clone of the beta subunit of human fibronectin receptor ( FNRB ) detects two different polymorphic loci : ( a ) a codominant system previously mapped to the pericentromeric region of chromosome 10 , the site of the functional FNRB gene ; and ( b ) a dominant system not linked to the first one or to any chromosome 10 marker tested . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Changes in the gene expression of collagens , fibronectin , integrin and proteoglycans during matrix induced bone morphogenesis . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Antibodies perturbing mouse and chicken integrin specific cell adhesions were used to demonstrate that the chimeric receptors functioned in adhesion to both laminin and fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The distribution of an adhesion receptor from the integrin family was mapped in cultured mammalian retinal pigment epithelial cells ( RPE ) , and in primate RPE cells in vivo , using antibodies to the human fibronectin receptor ( FnR ) in conjunction with indirect immunofluorescence and immunoelectron microscopy . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Integrin antibodies prevented adhesion and neurite sprouting of these cells on laminin , fragment P 1 , and fibronectin . ^^^ The effect of NGF is specific since the amount of a 150 kDa fibronectin binding integrin alpha subunit remained unchanged . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The distribution pattern of these integrin cell surface receptors was compared with that of two possible ligands , fibronectin and laminin , in the extracellular matrix during the time of neural crest cell migration . ^^^ Fibronectin and laminin were more extensively distributed than integrin at all stages examined . ^^^ The distribution of laminin and fibronectin around the somites was particularly interesting since it was non uniform and similar to that of integrin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The integrin subunit ( beta 1 ) is common to a group of plasma membrane glycoprotein heterodimers that include the fibronectin , laminin and collagen receptors . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| GpIIb / IIIa bound to a GRGDSPC peptide , but neither beta 1 containing integrins nor C CAM had any affinity either for this peptide or for a large cell binding fragment of fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| We have investigated the molecular basis of XTC MIF induced gastrulation like movements by measuring rates of synthesis of fibronectin and of the integrin beta 1 chain in induced and control explants . ^^^ In future work , we intend to investigate synthesis of other integrin subunits and to examine possible post translational modifications to fibronectin and the integrins . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Inhibition of binding of fibronectin to matrix assembly sites by anti integrin ( alpha 5 beta 1 ) antibodies . ^^^ Cell adhesion to fibronectin can be mediated by the interaction of an integrin ( alpha 5 beta 1 ) with the Arg Gly Asp Ser ( RGDS ) containing cell adhesion region of fibronectin . ^^^ We have attempted to elucidate the role of the alpha 5 beta 1 fibronectin receptor in assembly of fibronectin in matrices . ^^^ Rat monoclonal antibody mAb 13 , which recognizes the integrin beta 1 subunit , completely blocked binding and matrix assembly of 125I fibronectin as well as binding of the 125I 70 kD amino terminal fragment of fibronectin ( 70 kD ) to fibroblast cell layers . ^^^ Antibody mAb 16 , which recognizes the integrin alpha 5 subunit , partially blocked binding of 125I fibronectin and 125I 70 kD . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence of BAECs plated on laminin , fibronectin , and fibrinogen reveals different matrix binding specificities of each of these integrin subclasses . ^^^ By 1 h after plating , organization of beta 1 integrin into fibrillar streaks is influenced by laminin and fibronectin , whereas beta 3 integrin punctate organization is influenced by fibrinogen and the integrin spatial distribution changes with time in culture . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The beta subunit of the human fibronectin receptor ( FNRB ) is a transmembrane protein belonging to the VLA ( very late antigens of activation ) family . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Hybrid heterodimers consisting of exogenous beta 1 and endogenous alpha subunits bind effectively and specifically to columns of cell binding fragments of fibronectin . ^^^ In contrast , expression of a mutant form of avian integrin beta 1 subunit lacking the cytoplasmic domain produces hybrid heterodimers which , while efficiently exported to the cell surface and still capable of binding fibronectin , do not localize efficiently in focal contacts . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Here we extend our study of integrin structure and function in PC 12 cells using integrin subunit specific antibodies prepared against synthetic peptides corresponding to the cytoplasmic domains of the human integrin beta 1 and the fibronectin receptor alpha ( alpha FN ) subunits . ^^^ The purified integrins : ( a ) completely neutralize the ability of the anti ECMR serum to inhibit PC 12 cell adhesion to laminin and collagen 4 ; ( b ) have hydrodynamic properties that are very similar to those of previously characterized integrin alpha / beta heterodimeric receptors for ECM proteins ; and ( c ) can be incorporated into phosphatidylcholine vesicles that then bind specifically to substrates coated with laminin or collagen 4 but not fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Using anti band 3 , we have purified a second fibronectin receptor from human platelets , a heterodimer composed of glycoproteins previously designated GPIc and GPIIa . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| By contrast , 38 beta 7 and 38 beta 1 transfectants did not differ in their binding capacity for vascular cell adhesion molecule 1 ( VCAM 1 ) or fibronectin and LPAM 1 did not display any preference for interacting with either MAdCAM 1 or VCAM 1 . ^^^ Interestingly , functional analysis of the intraepithelial lymphocyte integrin alpha IEL beta 7 which is structurally related to LPAM 1 did not reveal detectable binding activity for MAdCAM 1 , VCAM 1 , or fibronectin . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The human beta 1 and beta 1 / 5 constructs appeared at similar levels at the cell surface ( mostly as alpha 5 beta 1 heterodimers ) and contributed equally to CHO cell adhesion to fibronectin . ^^^ However , beta 1 but not beta 1 / 5 localized to focal adhesion like structures when CHO cells were spread on fibronectin . ^^^ Furthermore , only the beta 1 CHO cells showed increased proliferation in response to fibronectin plus an integrin activating anti beta 1 antibody , and showed increased appearance of 32P labeled protein ( p 90 ) that correlated with proliferation . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Expression of a novel integrin beta 1 chain epitope and anti beta 1 antibody mediated enhancement of fibronectin binding are dependent on the stage of T cell differentiation . ^^^ In contrast with the loss of the epitope before TCR expression by other thymocytes , most CD3+4 8 and certain CD8+ gamma delta TCR+ thymocytes were KMI6+ Addition of KMI 6 to cell adhesion assays enhanced CD 4 8 thymocyte , but not activated mature thymocyte or peripheral T cell , binding to fibronectin ( via alpha 4 beta 1 and alpha 5 beta 1 ) , whereas laminin binding ( via alpha 6 beta 1 ) was unaffected . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In immunoglobulin A nephropathy , integrin beta 1 and alpha 5 beta 3 were seen by immunoelectron microscopy to be localized to the mesangial cell membranes in close proximity to the immune complex deposits ; however , fibronectin and vitronectin immunoreactivities were observed in the mesangial immune complex deposits . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| These mast cells and the other cell types present also adhere spontaneously to fibronectin and to laminin , this adhesion being partially inhibited by antibodies against CD 61 and CD 29 integrins . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Whether the peptide be present or not , cells cultivated in basal synthetic medium ( without FSH ) were flattened and attached to the substratum by stress fibers at focal contacts where integrin beta 1 , extracellular fibronectin , and urokinase plasminogen activator colocalized . ^^^ Correlatively , extracellular fibronectin aggregated in a clump , while integrin beta 1 and urokinase plasminogen activator spread over rounded cells . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The alpha 4 beta 1 integrin ( CD49d , CD 29 ) constitutively expressed on leukocytes regulates cell migration to inflammatory sites , cell activation , and development through its interactions with two alternate ligands , vascular cell adhesion molecule 1 ( VCAM 1 ; CD 106 ) expressed on cytokine activated endothelium , dendritic and stromal cells , and the extracellular matrix protein fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Focal adhesion complexes ( FACs ) containing integrin beta 1 , talin , vinculin , talin , alpha actinin , and paxillin formed within 15 min when round cells bound magnetic microbeads coated with integrin ligands , such as fibronectin or RGD containing peptide , but not when coated with acetylated low density lipoprotein . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Members of the beta 1 integrin subfamily recognize multiple ligands such as fibronectin , laminin , and collagen and mediate cell cell and cell extracellular matrix interactions . beta 1 subunit may play a central role in regulating beta 1 integrin avidity . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| However , when these two cell lines are plated on fibronectin ( FN ) , which is a ligand for alpha 5 beta 1 but not for alpha 1 beta 1 , there is a striking difference in the cellular localization of alpha 1 beta 1 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 5 beta 6 is expressed primarily in epithelial cells and mediates attachment to the extracellular matrix protein fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| On GCT cells we considered cytoskeletal organization , adhesion properties , and integrin expression upon plating in serum free medium onto fibronectin ( FN ) , collagen ( COL ) , thrombospondin ( TSP ) , bone sialoprotein ( BSPII ) , and osteopontin ( OPN ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Hybrid cells containing chromosome 10 were selected for the expression of the gene coding for the beta subunit of the fibronectin receptor ( FNRB ) , which maps to 10p11 . 2 , using a monoclonal antibody against FNRB . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| HTSC express CD 54 ( ICAM 1 ) , CD49a ( VLA 1 ) , CD49b ( VLA 2 ) , CD49c ( VLA 3 ) , CD49e ( VLA 5 ) , CD49f ( VLA 6 ) , CD 29 , CD 51 , CD 44 and produce vinculin , beta tubulin , alpha actin , vimentin , fibronectin , laminin and collagen types 1 , 3 and 4 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Adhesion of LPS U 937 cells treated with mNI 11 to fibronectin was completely blocked by CD 29 ( beta chain of very late antigens ) mAb . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Our data indicated that , while talin , vinculin , paxillin , fibronectin receptor and integrin beta 1 were present at the three stress fiber membrane association sites , vitronectin receptor and integrin alpha 5 were absent from the apical plaque and the lateral association site . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Antibody to the integrin beta 1 , chain ( CD 29 ) eliminated binding to collagen and laminin but not to fibronectin , fibroblasts , and HT 29 monolayers . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| We report a novel monoclonal antibody ( QE . 2E5 ) that binds within the cysteine rich repeats in the integrin beta 1 chain and induces high affinity binding of fibronectin to the integrin alpha5beta1 . ^^^ The QE . 2E5 epitope is located approximately 200 residues both from the predicted binding site for fibronectin and from the epitopes recognized by other activating anti beta 1 monoclonal antibodies . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In the binding assays , the numbers of FDCs bound to fibronectin and laminin coated dishes and LFs of cryostat sections of human tonsils were reduced markedly by pretreatment with monoclonal antibodies against CD 29 , CD49e , and CD49f . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| This phenomenon depended on differences in integrin mediated adhesion , because blocking of integrin beta 1 with a monoclonal antibody increased sensitivity of keratinocyte monolayers to UV and an increase in beta 1 integrin receptor occupancy by plating on fibronectin , type 4 collagen , or keratinocyte derived extracellular matrix diminished the UV dependent apoptosis . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Spermatozoa were incubated with antibodies against alpha 1 ( CD49a ) , alpha 2 ( CD49b ) , alpha 3 ( CD49c ) , alpha 4 ( CD49d ) , alpha 5 ( CD49e ) , alpha 6 ( CD49f ) chains of beta 1 integrins , beta 1 ( CD 29 ) , beta 2 ( CD 18 ) , alpha 5 ( CD 51 ) , beta 3 ( CD 61 ) and beta 4 integrin chains , the LFA 3 ( Lymphocyte function antigen , CD 58 ) from the immunoglobulin superfamily and the extra cellular matrix proteins laminin , fibronectin and collagen 4 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Therefore , the objectives of this study were to characterize conceptus gene expression for the steroidogenic enzymes 17alpha hydroxylase and aromatase and the mesodermal marker brachyury , as well as the expression of receptors for fibronectin ( integrin beta 1 ) , progesterone , estrogen , oxytocin , prostaglandin F2alpha , and leukemia inhibitory factor ( LIF ) , prior to and during trophoblastic elongation . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| We compared the effects of two anti beta 1 integrin activating antibodies , TS2 / 16 and AG 89 , on K 562 cell adhesion to fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Mac 2 binding protein is a cell adhesive protein of the extracellular matrix which self assembles into ring like structures and binds beta 1 integrins , collagens and fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The role of integrin beta 1 in human dental pulp cell adhesion on laminin and fibronectin . ^^^ OBJECTIVE : This study is to identify the expression of integrin beta 1 in human dental pulp cells and the role of integrin beta 1 in pulp cell adhesion on extracellular matrix protein laminin and fibronectin . ^^^ Dental pulp cell adhesion assay on extracellular matrix protein laminin and fibronectin and blocking cell adhesion was performed with monoclonal anti beta 1 antibody . ^^^ Monoclonal anti beta 1 antibody inhibited human dental pulp cells adhesion on laminin but not on fibronectin . ^^^ Human dental pulp cells also adhered on fibronectin but the adhesion was not regulated by beta 1 integrin . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We sought to determine whether expression of CD 51 ( vitronectin and fibronectin receptor ) , CD 54 ( intercellular adhesion molecule 1 ) , HLA DR ( activation marker ) , CD 29 ( beta 1 integrin ) , CD49b ( collagen receptor ) , and CD11b ( complement receptor ) exhibit a circadian rhythm in asthma . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Also , ICAP 1 contributes to beta 1 integrin dependent migration because ( 1 ) ICAP 1 transfection markedly increased chemotactic migration of COS 7 cells through fibronectin coated but not vitronectin coated porous filters , and ( 2 ) support of beta 1 dependent cell migration ( in Chinese hamster ovary cells transfected with various wild type and mutant beta 1 forms ) correlated with ICAP 1 association . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| ESC were plated on Petri dishes and 24 well plates coated with fibronectin , laminin , collagen 4 , poly L lysine , or mouse anti human integrin beta ( 1 ) and beta ( 2 ) monoclonal antibodies . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The Wnt 7a transduced cultures showed characteristics of a less mature culture with persistent expression of NCAM , N cadherin , wider distribution of integrin beta 1 and fibronectin , and suppression of tenascin C . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| ESCs were plated onto culture dishes coated with various extracellular matrix ( ECM ) substrates , such as fibronectin , laminin , collagen 4 , and poly L lysine , or mouse anti human integrin beta ( 1 , ) and beta ( 2 ) monoclonal antibodies . ^^^ IL 8 expression was induced by adherence of ESCs to fibronectin or collagen 4 , but not to poly L lysine , a non integrin dependent adhesion matrix . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Unlike skeletal muscle cells , fluorescence activated cell sorting analysis ( FACS ) showed no down regulation of the alpha 5 beta 1 fibronectin receptor during cell cycle withdrawal . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| A highly conserved 14 amino acid region of the chicken beta 1 integrin chain ( beta1chk residues 151 168 ) hypothesized to be involved in divalent cation coordination was analysed to determine whether invasin uses the same structural determinants as fibronectin ( Fn ) to recognize receptors . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrated that inhibition of extracellular matrix receptor , such as integrin beta 1 subunit , leads to cell arrest in G 1 , whereas EGF was found to up regulated integrin beta 1 and fibronectin in a MEK ERK dependent manner . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found that 14 3 3beta co localized with integrin beta 1 during the early stage of cell spreading on fibronectin , suggesting a potential role of the 14 3 3beta / integrin beta 1 interaction in the regulation of cell adhesion . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| When immobilized , it functions as a matrix protein equipotent to fibronectin in promoting cell adhesion by ligation and clustering of cell surface integrin receptors . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Of approximately 1200 genes in the array , those associated with integrin linked kinase ( ILK ) , fibronectin precursor and glycogen synthase kinase 3beta ( GSK 3beta ) were markedly stimulated after exposure of Hep3B cells to low oxygen ( 1 % ) for 6 h . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Blocking experiments using anti integrin beta 1 and beta 3 suggested that the increased haptotaxis of the HOXD 3 overexpressing cells to vitronectin resulted from increased expression and activation of integrin alphavbeta 3 , and that overexpression of the HOXD 3 gene converted the integrin beta 1 dependent haptotaxis to fibronectin into both integrin beta 1 and beta 3 dependent one . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Although expression of integrin beta 1 or alpha 4 on the cell surface of transfectants was not changed , wild type and His 321 mutant gelsolin , except for C del gelsolin , exhibited retardation of cell spreading , reduced chemotatic migration to fibronectin and suppressed lung colonization in spontaneous metastasis assay . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In their undifferentiated state , fetal blood MSCs were CD 29 ( + ) , CD 44 ( + ) , SH 2 ( + ) , SH 3 ( + ) , and SH 4 ( + ) ; produced prolyl 4 hydroxylase , alpha smooth muscle actin , fibronectin , laminin , and vimentin ; and were CD 45 ( ) , CD 34 ( ) , CD 14 ( ) , CD 68 ( ) , vWF ( ) , and HLA DR ( ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Expression array analysis followed by confirmatory semiquantitative reverse transcription PCR experiments demonstrated a significant progesterone dependent inhibition of expression of a cadre of cellular adhesion molecules , including fibronectin , integrin alpha 3 , integrin beta 1 , integrin beta 3 , and cadherin 6 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| METHODS : ( 1 ) Integrin beta ( 1 ) chain ( CD ( 29 ) ) and alpha ( 4 ) chain ( CD ( 49d ) ) expressions on CD ( 34 ) ( + ) cells were measured by flow cytometry in 30 untreated CML patients in chronic phase ( CML CP ) and 10 healthy donors . ( 2 ) The adhesion function of immunomagnetic beads selected CD ( 34 ) ( + ) cells to fibronectin was detected by crystal violet staining in 5 untreated CML CP patients and 5 healthy donors . ( 3 ) The effect of fibronectin on CFU GM colony formation of bone marrow cells in 3 CML patients and 3 healthy donors was observed by limited dilution liquid microculture . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Of all the glycoproteins and glycolipids containing Gal ( alpha ) 1 3Gal , two molecules , fibronectin and the integrin beta 1 subunit , were most intensely labeled by galactose oxidase , suggesting that these molecules may be preferentially exposed on the apical surface of the endothelium . ^^^ Binding of anti Gal ( alpha ) 1 3Gal antibodies to endothelial cell surfaces significantly diminished labeling of fibronectin and the integrin beta 1 subunit by galactose oxidase , indicating that these glycoproteins are targets for the antibodies when binding to intact porcine cells . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Significant changes were noted in the cellular localization of the respective collagen and fibronectin receptors , integrin alpha 1 and alpha 5 , from diffuse to a sarcomeric banding pattern . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Inactivation of the GTPase Rho in the human T lymphocytic cell line HPB ALL does not inhibit constitutively high adhesion to the integrin beta 1 substrate fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| We therefore analyzed the role of complement receptors 1 ( CD 35 ) and 3 ( CD11b / 18 ) , the lipopolysaccharide ( LPS ) receptor ( CD 14 ) , the beta ( 1 ) integrin chain of the fibronectin receptor ( CD 29 ) , the intercellular adhesion molecule 1 ( ICAM 1 , CD 54 ) and the transferrin receptor ( CD 71 ) in the complement independent uptake of L . pneumophila . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| We have therefore sought proof of principle as to whether small molecules that interact with the integrin beta 1 chain at or near the 4B4 binding site can modulate T cell costimulation and adhesion in the presence of type 1 collagen or fibronectin ( FN ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Antibody blocking of fibronectin ( FN ) adhesion or dominant negative inhibition of integrin beta 1 function alters cadherin mediated cell adhesion , promotes cell sorting behaviors in reaggregation assays , and inhibits medial lateral cell intercalation and axial extension in gastrulating embryos and explants . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The internalization by HUVECs was mediated by actin polymerization , and it was inhibited by RGDS ( Arg Gly Asp Ser ) tetrapeptide , antihuman fibronectin and antihuman integrin beta 1 monoclonal antibodies . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Expressions of specific genes , shown to be regulated in the cDNA array analysis , were analyzed in the individual samples using real time PCR . cDNA arrays showed that gene expressions for matrix metalloproteinase 2 ( MMP 2 ) , fibronectin subunit B ( FNRB ) , vascular endothelial growth factor ( VEGF ) , and mitogen activated protein kinase p 38 ( MAPKp 38 ) were up regulated , while matrix metalloproteinase 3 ( MMP 3 ) and decorin were down regulated , in tendinosis tissue compared with control tissue . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The formation of the cribriform structures appears to be related to a guided migration of astrocytes and the expression of integrin beta 1 and extracellular fibronectin in response to activation of EGFR . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Monocytes of type 1 diabetic patients displayed an increased adhesion to fibronectin in comparison with type 2 patients and healthy control subjects but had a normal expression of the FN binding integrins CD 29 , CD49a , CD49d , and CD49e ( although CD11b and CD 18 expression was increased ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| After contact with polyethylene terephthalate , a slight but significant decrease in the percentage of both CD 29 and CD49e positive cells was observed , which suggests a lower number of cells expressing the fibronectin receptor alpha5beta1 . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The adhesion strength of the primary human bone marrow cells to fibronectin coated substrate , by blocking the beta 1 integrin with and without antibodies , was also determined . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The current study is to investigate the modulation of basement membrane ( BM ) proteins , especially collagen 4 ( C 4 ) , laminin ( LN ) , and fibronectin ( FN ) in the invasive processes of human hepatocellular carcinoma ( HCC ) cells in vitro , and to reveal the roles of beta 1 integrins and RGD containing oligopeptide in the cell matrix interaction . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Glucose also increased cell adhesion molecules such as fibronectin , integrin beta 1 , and N cadherin at early stages and then decreased these adhesion molecules at later stages of chondrogenesis . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Integrin linked kinase ( ILK ) is an integrin binding cytoplasmic protein that has been implicated in regulating numerous cellular processes and fibronectin ( Fn ) deposition through mediated integrin , but the expression and significance of ILK in the aging kidney have not yet been reported . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The components of the fibronectin receptor , integrin beta 1 , alpha 5 , in conjunction with the ligand fibronectin , were up regulated during dedifferentiation . ^^^ In conclusion , a candidate for signal transmission during dedifferentiation is the fibronectin receptor ( integrin alpha5beta1 ) in conjunction with its ligand fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| At the same time , transfection also interfered with the recruitment of integrin beta 1 at the leading edge and reduced affinity binding to fibronectin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was a homogeneous cell population devoid of hematopoietic cells , which uniformly expressed CD 29 , CD 44 , CD 73 , CD 105 , CD 166 , laminin , fibronectin and vimentin while being negative for expression of CD 31 , CD 34 , CD 45 and alpha smooth muscle actin . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Because anti integrin beta 1 blocking antibodies also prevent binding of Karpas 299 to fibronectin and collagen 1 , we then evaluate the CD 26 integrin beta 1 association . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Fibronectin ( Fn ) , a large glycoprotein , is expressed at high levels in arthritic joints and it mediates various physiological processes through interactions with cell surface integrin receptors and growth factors . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In addition , we identified several proteins that have not been correlated previously with pancreatic cancer including perlecan ( HSPG 2 ) , CD 9 antigen , fibronectin receptor ( integrin beta 1 ) , and a novel cytokine designated as predicted osteoblast protein ( FAM3C ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Moreover , the coculture results showed that fibronectin , an extracellular matrix component , and integrin beta 1 , a receptor of fibronectin , were detected in high amounts on both cells , suggesting our collagen vitrigel can provide a suitable environment for cell cell interactions that stabilize the cell structure and may contribute to the polarity formation of epithelial cells . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Plasma membrane associated sialidase ( NEU 3 ) differentially regulates integrin mediated cell proliferation through laminin and fibronectin derived signalling . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| For detection of viability and differentiation , WST 1 assay , determination of alkaline phosphatase activity , concentration of procollagen 1 peptide , concentration of osteocalcin , and indirect immunofluorescence for osteopontin , collagen type 1 , integrin beta 1 , and fibronectin were applied . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Here we showed that control , Shp 2 / , integrin beta 1 / , and talin 1 / cell lines all spread to a threefold greater area on fibronectin ( FN ) coated rigid polyacrylamide surfaces than soft . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The expression levels of Ln 5 and fibronectin ( Fn ) were determined by Western blot analysis , and the expression levels of the beta 1 and alpha 3 integrins were determined by confocal microscopy and Western blot analysis . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression indexes of integrin alpha 5 and beta 1 on K 562 cells , the binding capability of K 562 cells to fibronectin ( FN ) , and K 562 cell FN binding blocking induced by integrin alpha 5 and beta 1 antibodies were evaluated by flow cytometry ( FCM ) . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The SHG 44 cells transfected with antisense cDNA of GalT 5 demonstrated decreased Golgi localization of integrin beta 1 , strengthened the interaction between integrin alpha 5 and beta 1 subunit , and enhanced the adhesion ability to fibronectin and the level of focal adhesion kinase phosphorylation . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| The formation of these processes is shown to require the interaction between the beta 1 integrin ( CD 29 ) on the surface of the DCs and fibronectin in the extracellular matrix . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| When surface radioiodinated MEC were solubilized and subjected to affinity chromatography on Fn Sepharose columns , two polypeptides of 150 and 125 kD , corresponding to the integrin heterodimer alpha 5 beta 1 , were identified . ^^^ Immunofluorescent staining of MEC cultures with antibodies to the integrin beta 1 subunit demonstrated receptors on the basolateral surface at focal adhesion plaques that co localized with vinculin and with Fn positive matrix fibers . ^^^ However , in cultures of MEC that were attached to substrates coated with alternating strips of Fn and Vn , the beta 1 complex was preferentially localized to the Fn substrate , while the Vn receptor was concentrated on the Vn substrate . ^^^ The results indicate that MEC express at least two different heterodimer adhesion receptors that belong to the integrin super family and appear to have distinct ligand specificities : the Fn receptor and the Vn receptor . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| However , when a rapid reorganization of the cytoskeleton was induced using lysophosphatidic acid ( LPA ) , IL2R beta 1 cells detached from FN in contrast to wild type cells . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In contrast with the activating CD 29 mAb 8A2 , a combination of blocking CD 49 mAbs or the nonactivating but blocking CD 29 mAb AIIB 2 failed to inhibit completely eosinophil migration over FN preincubated or HUVEC covered filters . mAb 8A2 stimulated binding to FN but not to HUVEC . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Using a combination of immunofluorescence microscopy , immunoprecipitation and blocking assays with integrin specific antibodies , we found ( 1 ) that expression of the alpha3beta1 integrin on metastatic mammary carcinoma cells was specifically increased in comparison to non metastatic cells and ( 2 ) that the alpha3beta1 receptor was involved in the increased adhesion of metastatic cells to lymph node FN and in cell spreading on FN coated substrates . ^^^ Our data implicate the alpha3beta1 integrin in adhesion to lymph node stromal cell FN and suggest that metastatic cells of different tissue origins ( e . g . , melanoma and breast carcinoma ) may utilize distinct integrin ligand combinations to colonize the same target organ . . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Adhesion to FN was mediated by beta 1 integrins alpha 4 beta 1 ( VLA 4 ) and alpha 5 beta 1 ( VLA 5 ) since blocking antibodies against beta 1 ( CD 29 ) , alpha 4 ( CD49d ) , or alpha 5 ( CD49e ) integrin subunits , completely reversed the effect of HGF / SF . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Antibody directed against integrin beta 1 inhibited FBS , Fn , and Lm mediated invasion but did not abrogate RGD peptide stimulated invasion . ^^^ MAb directed against the epithelial cell Fn receptor , integrin alpha5beta1 , inhibited Fn and FBS mediated invasion but did not specifically inhibit Lm mediated invasion . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| A peptide corresponding to integrin beta 1 [ 140 164 ] ( DDL ; DYPIDLYYLMDLSYSMKDDLENVKS ) inhibited decidual cell attachment to FN coated dishes in a dose dependent manner . ^^^ A variant integrin peptide in which Asp 157 and Asp 158 were replaced by Ala ( AAL ; DYPIDLYYLMDLSYSMKAALENVKS ) did not affect decidual cell attachment to FN . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Studies using blocking antibodies indicated the involvement of CD11a in binding to ICAMs , and of CD49d , CD49e , and CD 29 in binding to FN . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Adherent and nonadherent monocyte populations from TAID patients and healthy controls were subjected to a polarization test with the chemoattractant fMLP ( or MCP 1 ) , FACS analyses ( FITC labelled FN , CD 29 , CD49e , d , b and a ) and tested for their capability to develop into veiled APC . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| In contrast , marrow PC from progressive patients and BM or circulating malignant cells from secondary PCL patients expressed lower levels or were negative for CD 106 and activated CD 29 , respectively , with a decreased or zero ability to adhere to FN . ^^^ |
|
| Interacting proteins: P02751 and P05556 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when AngRem 104 was overexpressed by transfection of its sense construct , cDNA Microarray showed that two of the ECM related genes , i . e . , human mRNA for FN and integrin beta 1 ( FN receptor ) , dramatically upregulated their expressions . ^^^ |
|