| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.51982569 |
| Aggregated SAP selectively binds fibronectin and this may represent an aspect of the normal function of SAP . 0.51982569^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.85805549 |
| Previous observations indicating that SAP binds to extracellular matrix components such as type 4 collagen , proteoglycans , and fibronectin in concert with the data presented here suggest that SAP may play an important role in determining the structure of those basement membranes with which it is associated . . 0.85805549^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| However , when the protein is aggregated by immobilized antibodies , C4bp and fibronectin clearly bind to SAP . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| SAP neutralized the catalytic effect of heparin on the thrombin antithrombin 3 reaction more effectively than vitronectin , histidine rich glycoprotein , fibronectin , and high molecular weight kininogen and almost as effectively as platelet factor 4 . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| Hepatic levels of mRNA specific for total serum amyloid A ( SAA ) , the SAA 1 and SAA 2 isotypes , serum amyloid P ( SAP ) , C reactive protein ( CRP ) , and fibronectin , as well as the plasma concentrations of SAA and SAP were examined in amyloid resistant ( A / J ) and amyloid susceptible ( CBA / J ) mice during azocasein induced chronic inflammation . ^^^ |
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| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| SAP binds in a calcium dependent fashion to various ligands , such as agarose , desoxyribonucleic acid , fibronectin , C 4 binding protein , glycosaminoglycans and isolated amyloid fibrils . ^^^ Since SAP binds to fibronectin and glycosaminoglycans , which in turn bind to collagen fibers , TAP on elastic fiber microfibrils may play an important role in the maintenance of the normal dermal architecture and in dermo epidermal adhesion . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| The acute phase proteins , fibronectin ( Fn ) and serum amyloid P ( SAP ) , are opsonins which by virtue of their adhesive properties may be involved in the glomerular nephritis associated with splenic lupus erythematosus ( SLE ) . ^^^ Because of their possible involvement in the pathophysiology of lupus , plasma Fn and SAP levels from three strains of autoimmune mice were measured over time to determine if Fn and SAP rose as the mice sickened and renal function degenerated . ^^^ Baseline levels of Fn and SAP were measured when the mice were between 1 . 5 and 3 months of age . ^^^ The characteristic rapid onset of autoimmune disease in MRL / 1pr mice was accompanied by a two to threefold increase in plasma Fn and SAP by Day 100 . ^^^ The B / W mice , which develop autoimmune disease more slowly , did not have a significant increase in plasma Fn and SAP until Day 240 . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to characterize a suppressive active glycopeptide ( SAP ) using affinity chromatography ( AFFI ) and explore its similarity to fibronectin ( FN ) degradation products . ^^^ It is postulated that SAP is a degradation fragment of a large serum borne protein , possibly FN . ^^^ Human trauma serum ( HTS ) and elastase degraded human FN were run over an AFFI prepared with monoclonal antibody to SAP . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| Binding between purified mouse serum amyloid P component ( SAP ) and plasma fibronectin ( Fn ) occurred when either one of the proteins was immobilized by specific antibody and the second protein was offered in a soluble form . ^^^ Binding of Fn to immobilized SAP was cooperative and saturable at a molar ratio of SAP / Fn = 7 . 1 . ^^^ The molar ratio at saturation was 3 . 7 for SAP / Fn when SAP was allowed to bind to immobilized Fn . ^^^ The binding of SAP to Fn was selectively inhibited by a monoclonal antibody specific for the mid molecule region of Fn , by soluble gelatin , and by heparin in the presence of 3mM Ca++ . ^^^ We conclude that the SAP binding site was localized at the mid molecule region of Fn that includes the adjacent gelatin binding domain and the heparin 1 binding domain . . ^^^ |
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| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin ( FN ) and serum amyloid P component ( SAP ) markedly enhance phagocytosis mediated by the C3b and C3bi receptors of cultured human monocytes but not of granulocytes . ( The C3b and C3bi receptors of granulocytes can be activated by treatment of these phagocytes with PMA . ) Activation of monocyte C 3 receptors by FN is developmentally regulated : Freshly explanted monocytes respond to FN with a small increase in C 3 receptor mediated phagocytosis while monocytes matured in culture exhibit a much greater response . ^^^ Fibronectin ( FN ) and serum amyloid P component ( SAP ) markedly enhance phagocytosis mediated by the C3b and C3bi receptors of cultured human monocytes but not of granulocytes . ( The C3b and C3bi receptors of granulocytes can be activated by treatment of these phagocytes with PMA . ) Activation of monocyte C 3 receptors by FN is developmentally regulated : Freshly explanted monocytes respond to FN with a small increase in C 3 receptor mediated phagocytosis while monocytes matured in culture exhibit a much greater response . ^^^ First , while substrate bound FN or SAP activate monocyte C 3 receptors , soluble FN does not . ^^^ Second , stimulation of the basal surface of monocyte plasma membranes by substrate bound FN activates C3b and C3bi receptors on the apical surface of the plasma membrane , i . e . , at sites remote from the segments of membrane in contact with the FN or SAP . . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence staining of exposed skin from patients with erythropoietic protoporphyria ( EPP ) with antibodies to serum amyloid P component ( SAP ) and to fibronectin produced striking fluorescence of abnormal vascular structures in the upper dermis . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| In vitro SAP binds to a variety of proteins including fibronectin , proteoglycans , and the collagen like region of the complement component C1q . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| By binding assay on the microtiter plate , SAA had more affinity to fibronectin than those of heparan sulfate , collagen type 1 , or serum amyloid P component . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| In particular , the extracellular matrix ( ECM ) proteins fibronectin and laminin and serum amyloid P component can increase the phagocytic activity of these cells . ^^^ |
|
| Interacting proteins: P02743 and P02751 |
Pubmed |
SVM Score :0.0 |
| In addition to adsorption of LDL , DSC adsorbs plasma constituents that have the following characteristics : proteins containing apolipoprotein B ( Lp [ a ] ) ; proteins involved in the initial contact phase of the intrinsic coagulation pathway ( coagulation factor 12 , high molecular weight kininogen and prekallikrein ) ; factors with lipophilic characteristics ( coagulation factor 7 , coagulation factor 8 , and vitamin E ) ; and proteins with adhesive or other characteristics ( von Willebrand factor , fibronectin , serum amyloid P component , hepatocyte growth factor ) . ^^^ |
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