| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.51562994 |
| CRP binds with high affinity to purified plasma fibronectin ( Fn ) when the Fn is immobilized on a surface or matrix via either specific IgG antibody or by gelatin . 0.51562994^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.91001291 |
| CRP was found also to bind fibrinogen , which competed with fibronectin for CRP binding sites . 0.91001291^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.84554267 |
| Before the treatment , fibronectin was found to be positively correlated with CRP and total cholesterol ( r=0 . 38 , p < 0 . 05 and r=0 . 33 , p < 0 . 05 , respectively ) and negatively correlated with high density lipoprotein cholesterol ( HDL C ) ( r= 0 . 42 , p < 0 . 01 ) in patients with dyslipidaemia . 0.84554267^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin and fibrinogen are bound by surface immobilized CRP also in soluble phase . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In ELISA assay , CRP was found to bind to immobilized fibronectin with dose dependency , only in the presence of Ca2+ ions . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| CRP also binds to other proteins including fibronectin . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Plasma fibronectin level changes appear earlier than that of C reactive protein ( Crp ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Albumin , fibronectin and CRP , whose affinity for IgM , C1q and C 3 are known , were co isolated along with IC material . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| No significant correlation was observed in SpA patients between each Fn level and clinical activity , ESR or CRP levels . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Peptides containing the sequences responsible for the cell attachment activity of the extracellular matrix proteins , fibronectin ( Fn ) and laminin , failed to inhibit the CRP derived peptide cell attachment activity . ^^^ However , the addition of the RGDS and RGDSPASSLP cell binding peptides of Fn to cells enhanced attachment to the active peptide from CRP . ^^^ In the converse experiment , the cell binding peptide of CRP did not influence cell attachment to Fn or laminin . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Residues Tyr 40 and Glu 42 do not appear to participate in the formation of the PCh binding site of CRP , however , they may be located in the vicinity of the fibronectin binding site of CRP . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Hepatic levels of mRNA specific for total serum amyloid A ( SAA ) , the SAA 1 and SAA 2 isotypes , serum amyloid P ( SAP ) , C reactive protein ( CRP ) , and fibronectin , as well as the plasma concentrations of SAA and SAP were examined in amyloid resistant ( A / J ) and amyloid susceptible ( CBA / J ) mice during azocasein induced chronic inflammation . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Serum levels of C reactive protein ( CRP ) and plasma levels of fibronectin ( Fn ) were studied in 74 untreated leprosy patients . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The effects of three types of plasma substitutes , crystalloid , gelatin and dextran solutions , on plasma fibronectin levels were studied in patients undergoing abdominal surgery in relation to serum total protein and serum C reactive protein ( CRP ) levels . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The synthetic peptide , like CRP , binds to the extracellular matrix protein fibronectin and the basement membrane protein laminin . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| There was a correlation between the clinical condition and concentrations of acid alpha 1 glycoprotein , IgG , CRP and fibronectin . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that purified human C reactive protein ( CRP ) specifically binds to the cell binding region of plasma fibronectin ( Fn ) in a Ca2+ dependent reaction that is saturable at a molar ratio of CRP / Fn of approximately 9 . ^^^ In this study , the binding of CRP to Fn was found to interfere with the cell attachment promoting activity of Fn . ^^^ Since CRP is selectively deposited at sites of tissue damage along with plasma Fn and has the ability to bind to Fn and alter its cell binding activity , CRP may modulate early events in tissue repair . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The purpose of the study was to determine the temporal relationship between lymphocyte activating factor ( LAF ) activity and the acute phase response , as measured by plasma fibronectin ( Fn ) , C reactive protein ( CRP ) , and albumin levels in adjuvant arthritic rats . ^^^ LAF activity as measured in the thymocyte costimulator assay , and plasma Fn , CRP , and albumin levels were measured during the acute ( Day 3 ) , intermediate ( Day 10 ) , and systemic ( Day 17 ) phases of arthritic disease . ^^^ In contrast to the time course of IL 1 activity , Fn and CRP levels in the arthritic rat were significantly higher than normal at all three time points , although there was a transient fall in Fn and CRP concentrations on Day 10 . ^^^ The acute , intermediate , and systemic phases of adjuvant arthritic paw inflammation paralleled the abnormal profile of Fn , CRP , and albumin concentrations over time . ^^^ Since the appearance of abnormal plasma protein levels in arthritic rats preceded the appearance of increased splenic LAF activity , it appears that there is no causal relationship between enhanced splenic LAF activity and early alteration of plasma Fn , CRP , and albumin levels . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Parameters of the acute phase response consisted of plasma fibronectin ( Fn ) , C reactive protein ( CRP ) , albumin and iron . ^^^ When compared to normal animals , AA rats had significantly ( P less than or equal to 0 . 01 ) increased : ( 1 ) splenic LAF activity ( 100 % increase ) , ( 2 ) plasma Fn ( 58 % ) , and ( 3 ) CRP ( 122 % ) , as well as abnormally reduced levels of : ( 1 ) plasma albumin ( 53 % reduction ) , and ( 2 ) iron ( 54 % ) . ^^^ The inhibition of the acute phase response was measured by reduction of high plasma Fn levels ( 42 79 % decrease ) and CRP levels ( 57 100 % decrease ) as well as elevation of subnormal levels of plasma albumin ( 57 101 % increase ) and iron ( 40 114 % increase ) . ^^^ Dosing with the nonsteroidal anti inflammatory drugs ( NSAIDs ) , aspirin ( 50 and 100 mg / kg ) or phenylbutazone ( 10 and 30 mg / kg ) , significantly inhibited paw inflammation ( 29 85 % ) , but did not decrease the high rate of splenic LAF activity , nor did aspirin ( 55 , 100 and 200 mg / kg ) or phenylbutazone ( 1 , 10 and 30 mg / kg ) alter the acute phase response in AA rats , as measured by levels of plasma Fn , CRP , albumin and iron . ^^^ Since CS A and MTX have been reported to be effective in the treatment of RA , their activity in the LAF , Fn , CRP , albumin and iron assays of the AA rat suggests that these immunological and serological parameters may be useful in identifying potential antirheumatic drugs and distinguishing them from standard NSAIDs . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Auranofin , a member of a class of compounds with disease modifying activity , was given to arthritic rats to determine if it could reverse the abnormal plasma concentrations of fibronectin ( Fn ) , C reactive protein ( CRP ) , and albumin , which were unaffected by treatment with non steroidal anti inflammatory drugs ( NSAIDs ) . ^^^ At the 3 mg / kg dose , auranofin did not significantly change plasma concentrations of Fn , CRP , and albumin in arthritic rats . ^^^ At a dose of 10 mg / kg , however , auranofin , in addition to inhibiting chronic systemic paw inflammation , also altered abnormal concentrations of plasma Fn , CRP , and albumin in the adjuvant arthritic rat , thus distinguishing auranofin from standard NSAIDs we have previously tested . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The amount and protein composition of heparin precipitable fraction ( HPF ) , and the plasma concentrations of fibrinogen , fibronectin , alpha 1 acid glycoprotein , alpha 1 antitrypsin , haptoglobin and C reactive protein ( CRP ) were determined in healthy subjects as well as during the course of acute myocardial infarction ( AMI ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| With regard to other indicators of infection , CRP , ESR , and WBC were higher in CAM ( + ) patients and fibronectin was detected ( > 50 ng / ml ) in the cervical mucus of all CAM ( + ) patients . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In 63 patients ( 31 active , 32 inactive ) with BD , plasma Fn and serum CIC , C reactive protein ( CRP ) , erythrocyte sedimentation rate ( ESR ) and the third and fourth components of the complement system ( C 3 , C 4 ) were studied . ^^^ Moreover , no significant correlation was observed among Fn levels and ESR , CRP , C 3 , C 4 and CIC levels in BD patients . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Interleukin 6 ( IL 6 ) , sCD 14 , and tumour necrosis factor alpha ( TNF alpha ) were measured by enzyme immunoassay , and fibronectin ( FN ) and C reactive protein ( CRP ) by radial immunodiffusion . ^^^ Neonates with a positive blood culture had increased levels of sCD 14 ( 3 . 20 + / 1 . 26 micrograms ml 1 , p < 0 . 001 ) , CRP ( 69 + / 46 micrograms ml 1 , p < 0 . 001 ) and IL 6 ( 134 + / 150 pg ml 1 , p < 0 . 001 ) , and decreased values of FN ( 12 . 3 + / 6 . 6 mg ml 1 , p < 0 . 001 ) . ^^^ In contrast , IL 6 , TNF alpha , CRP and FN values are similar in infections by Gram positive and Gram negative bacteria . . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Our objective was to investigate the initial levels of circulating proinflammatory cytokines , such as interleukin 1 beta ( IL 1 beta ) , interleukin 6 ( IL 6 ) , and tumour necrosis factor alpha ( TNF alpha ) , of certain acute phase proteins , such as C reactive protein ( CRP ) , fibrinogen ( FBN ) and albumin , and of the glycoprotein fibronectin at presentation and their daily variation during the clinical course of community acquired pneumonia ( CAP ) in relation to clinical and laboratory indices of infection . ^^^ Initial CRP levels were increased 90 fold ( 416 + / 1 mg L 1 ) , whereas fibronectin levels were reduced ( 242 + / 9 mg dL 1 ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Baseline positive APP due to severe trauma include C reactive protein ( CRP ) , alpha 1 antichymotrypsin , alpha 1 acid glycoprotein , alpha 1 antitrypsin , fibronectin , and factor B . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Plasma interleukin 1 beta ( IL 1 beta ) , IL 2 , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , group 2 phospholipase A 2 , ( PLA 2 ) , endotoxin , fibronectin and serum C reactive protein ( CRP ) concentrations were measured . ^^^ The operation increased plasma IL 6 , group 2 PLA 2 , and serum CRP concentration and decreased plasma fibronectin concentrations . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Exhibiting this function , C1q is able to bind various molecules ( complexed IgG , IgM , fibrinogen , fibronectin , lipopolysaccharides , DNA , C reactive protein [ CRP ] , and viral proteins ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| CRP binds to a range of substances such as phosphocholine , fibronectin , chromatin , histones , and ribonucleoprotein in a calcium dependent manner . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In the present study we measured plasma C reactive protein ( CRP ) as a sensitive marker of an acute phase reaction in 474 thrombosis patients and 474 age and sex matched healthy controls , that were part of the Leiden Thrombophilia Study ( LETS ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| To bind FN to surfaces , we used two different CRPs : CRP 1 ( TLQPVYEYMVGV ) and CRP 2 ( TGLPVGVGYVVTVLT ) . ^^^ The results of our studies demonstrated that although CRP 1 and CRP 2 could be bound directly to polystyrene , these directly immobilized CRPs failed to bind ( 125 ) 1 FN . ^^^ When CRP BSAs were immobilized on polystyrene , they all successfully bound ( 125 ) 1 FN in a range of 34 72 ng / cm2 ( mean ) . ^^^ Using monoclonal antibodies to FN to characterize the orientation of FN bound to the various CRP BSAs , we demonstrated that ( 1 ) FN consistently bound to either CRP 1 BSA or CRP 2 BSA ; ( 2 ) bound FN reacted significantly more with anti C antibodies than with anti N antibodies ; and ( 3 ) the increased reactivity of bound FN to anti C antibodies was consistent , whether FN was bound by CRP 1 or CRP 2 or the CRPs were bound to BSA by the C or N termini . ^^^ Alternatively , in this orientation the N termini of the FN would not be available to bind the anti N antibodies , thereby explaining the decreased reactivity of the CRP immobilized FN to the anti N antibodies . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| CRP also binds , in a PCh inhibitable manner , to ligands that do not contain PCh , such as fibronectin ( Fn ) . ^^^ Five CRP mutants , F66A , F66Y , E81A , E81K , and F66A / E81A , were constructed , expressed in COS cells , purified , and characterized for their binding to PnC , PCh BSA , and Fn . ^^^ In contrast , all five CRP mutants bound to Fn as well as did wild type CRP . ^^^ The data also suggest that the binding sites for PCh and Fn on CRP are distinct . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| In this prospective study , we monitored two laboratory parameters , C reactive protein ( CRP ) and fibronectin ( FIN ) levels , in 30 patients undergoing elective surgery for ischemic heart disease . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The relationship between the levels of C reactive protein ( CRP ) and fibronectin ( FN ) and atherosclerotic diseases such as coronary heart disease has already been studied , but their relationship with cerebrovascular events has not . ^^^ The aim of this study was to determine the levels of plasma FN and serum CRP in cerebrovascular events , and their relationship with the outcome of the disease . ^^^ CRP and FN levels were analysed in 133 patients with acute cerebrovascular disease , together with 66 healthy controls . ^^^ FN and CRP levels in patients with cerebrovascular disease were found to be significantly elevated compared with the control group ( p < 0 . 001 ) . ^^^ CRP levels correlated with disease severity , in contrast to FN levels . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Fibronectin , lipids , C reactive protein ( CRP ) and fibrinogen levels were determined . ^^^ Fibronectin levels were positively correlated with CRP ( r = 0 . 45 , P < 0 . 001 ) , low density lipoprotein cholesterol ( r = 0 . 23 , P = 0 . 03 ) and total cholesterol ( r = 0 . 21 , P = 0 . 04 ) levels and negatively correlated with high density lipoprotein cholesterol ( HDL C ) levels ( r = 0 . 24 , P = 0 . 02 ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| There was a significant correlation between the mean change of BMD at the FN and mean change of tender joint count ( p=0 . 01 ) , ESR ( p=0 . 008 ) , and CRP ( p=0 . 006 ) but not with swollen joint count ( p=0 . 099 ) . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Differential binding patterns with antibodies against human CRP , human IgG , and other ligands like fibronectin , fetuin , and asialofetuin indicated that the purified CRPs differed significantly in their lectin like interactions . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| C reactive protein ( CRP ) binds with high affinity to fibronectin ( Fn ) , a major component of the extracellular matrix ( ECM ) , but at physiological pH the binding is inhibited by calcium ions ( Ca2+ ) . ^^^ Because CRP circulates in the blood in Ca2+ bound form , the occurrence of CRP Fn interactions in vivo has been doubtful . ^^^ To define the basis of inhibition of CRP Fn interaction by Ca2+ at pH 7 . 0 , we hypothesized that Fn binding site on CRP consisted of amino acids co ordinating Ca2+ . ^^^ Site directed mutagenesis of amino acids co ordinating Ca2+ drastically decreased the binding of CRP to Fn , indicating that the Ca2+ binding site indeed formed the Fn binding site . ^^^ To determine the requirements for possible interaction between Ca2+ bound CRP and Fn , we investigated inhibition of CRP Fn interaction by Ca2+ as a function of pH . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| The other infectious markers tested were : bacterial vaginosis and fetal fibronectin in cervical secretions ; serum CRP and white blood cell count . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| We measured VEGF A , PlGF , SCF , MMP 9 , EDB+ fibronectin , sVEGFR 2 , sVEGFR 1 , salphaVbeta 3 , sTie 2 , IL 8 and CRP in the blood of 22 healthy volunteers , 17 early breast , 17 early colorectal , and 8 advanced sarcoma / melanoma cancer patients . ^^^ |
|
| Interacting proteins: P02741 and P02751 |
Pubmed |
SVM Score :0.0 |
| Peripheral levels of fibronectin ( microg / mL ) , von Willebrand factor antigen ( % ) , C reactive protein ( high sensitive CRP , mg / L ) , urinary albumin , and protein ( 24 hour collection , g / mol creatinine ) served as markers of vascular damage . ^^^ Women with enhanced platelet responsiveness had higher levels of circulation fibronectin and CRP , and displayed more often albuminuria and proteinuria . ^^^ |
|