| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| By ELISA , a preferential quantitative binding order of Fn to the major Ig classes and subclasses was obtained as follows : IgG greater than IgM greater than IgA , IgG 1 greater than IgG 3 = IgG 4 greater than IgG 2 , and IgA 1 = IgA 2 . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| Second , it was shown that IgA 1 adhesion activities to type 4 collagen , fibronectin , and laminin were significantly higher in asialo , agalacto , and naked IgA 1 than in native IgA 1 , using enzyme linked immunosorbent assay ( asialo , agalacto , and naked versus native : P < 0 . 01 ) . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| Since fibronectin is known to be involved in the assembly of extracellular matrix , this study was conducted to investigate whether fibronectin and its fragments are present in sera of patients and are capable of binding IgA 1 . ^^^ The capacity of fibronectin to bind IgA was examined with a mixture of purified IgA 1 and cathepsin D digested fibronectin fragments . ^^^ Since the carboxy terminal domain is known to be critical in assembling exogenous fibronectin into the extracellular matrix , the affinity to IgA 1 to a fragment found in patients may have pathogenic potential to mediate extracellular IgA deposition in IgA nephropathy . . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| Because aberrant IgA 1 glycosylation is the event initiating IgA nephropathy in humans , we speculate that the enhanced incorporation of UG into IgA Fn complexes might represent feedback to reduce the formation of macromolecular aggregates . . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| IgA nephropathy patients display increased or borderline serum IgA levels ; increased serum levels of IgA fraction with degalactosylated O linked side sugar chains ; increased serum levels of anti N acetylgalactosamine antibodies ; increased levels of circulating immune complexes composed of IgA 1 complexed with IgG or IgA 1 ; increased serum levels of circulating complexes composed of IgA and fibronectin ; and frequent occurrence of the rheumatoid IgA factor . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| The binding was specific because it was only inhibited by unlabelled Mono IgA 1 ( mIgA 1 ) and not by serum albumin or IgG . aIgA 1 from patients with IgAN could induce release of intracellular calcium , phosphorylation of ERK , DNA synthesis , proliferation of HMC , expression of TGF betamRNA and secretion of fibronectin in HMC in a similar time dependent manner as aIgA 1 from healthy controls , but the effects were much stronger and the durations were much longer ( P < 0 . 05 , respectively ) . ^^^ |
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| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01876 and P02751 |
Pubmed |
SVM Score :0.0 |
| NA |
|