| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.52448468 |
| Structural differences exist between human and mouse A apoproteins because : 1 ) human cholesterol ester transfer protein , lecithin cholesterol acyl transferase and phospholipid transfer protein interact better with human apoA 1 ; 2 ) human apoA 1 and A 2 , alone or in combination , form polydisperse instead of monodisperse HDL particles . 0.52448468^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.57701217 |
| Active plasma phospholipid transfer protein is associated with apoA 1 but not apoE containing lipoproteins . 0.57701217^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.8914567 |
| These results show that PLTP binds to both apoA 1 and apoA 2 , and that the PLTP binding domain of apoA 1 resides in the amino terminal region . . 0.8914567^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Ultracentrifugally isolated HDL subclasses ; concentrations of apoA 1 , apoA 2 , LpA 1 and LpA 1 : A 2 particles ; post heparin plasma lipoprotein lipase ( LPL ) , hepatic lipase ( HL ) and plasma cholesteryl ester transfer protein ( CETP ) activities ; phospholipid transfer protein ( PLTP ) and lecithine cholesteryl acyltransferase ( LCAT ) activities were measured in plasma from six patients from both groups . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Phospholipid transfer protein ( PLTP ) mediates conversion of high density lipoprotein ( HDL 3 ) to large particles , with concomitant release of apolipoprotein A 1 ( apoA 1 ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Moreover , alterations of proteins associated with HDL metabolism ( e . g . , paraoxonase , apolipoprotein A 1 , lecithin : cholesterol acyltransferase , cholesterol ester transfer protein , hepatic lipase , phospholipid transfer protein , and serum amyloid A ) could decrease the ability of HDL to protect against atherogenesis through antioxidation and reverse cholesterol transport mechanisms . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| A comparison of the properties of the pro and mature forms of recombinant apoA 1 and human plasma apoA 1 showed no difference between all three in their secondary structure , their ability to self associate , lipid binding capacity , lecithin : cholesterol acyltransferase activation , and binding to the phospholipid transfer protein . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma lipids , apolipoprotein AI , phospholipid transfer protein ( PLTP ) activity , pre beta high density lipoproteins ( HDL ) in incubated plasma and efflux of radiolabelled cholesterol from Fu5AH rat hepatoma cells to plasma were measured at each time point . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Prebeta migrating , lipid poor apoA 1 is also generated as a product of the remodelling of HDL by phospholipid transfer protein . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| The phospholipid transfer protein ( PLTP ) activity of plasma containing the apoA 1 [ Delta ( 89 99 ) ] mutant was decreased to 32 % of the WT control . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Fenofibrate stimulated liver fatty acid beta oxidation , increased the transcriptional expression of carnitine palmitoyltransferase 1 and phospholipid transfer protein , and decreased expression of apoA 1 and apoC 3 . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Major constituents of RCT include acceptors such as high density lipoprotein ( HDL ) and apolipoprotein A 1 ( apoA 1 ) , and enzymes such as lecithin : cholesterol acyltransferase ( LCAT ) , phospholipid transfer protein ( PLTP ) , hepatic lipase ( HL ) and cholesterol ester transfer protein ( CETP ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| In this brief review , we propose that spherical apoAI is derived from HDL by remodeling events that are accomplished by proteins secreted by cholesteryl ester loaded foam cells , including the lipid transfer proteins , phospholipid transfer protein , and cholesteryl ester transfer protein , and the triglyceride hydrolases hepatic lipase and lipoprotein lipase . . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Increased prebeta high density lipoprotein , apolipoprotein AI , and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| ApoA II / apoA 1 molar ratio in the HDL particle influences phospholipid transfer protein mediated HDL interconversion . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown that plasma phospholipid transfer protein ( PLTP ) converts isolated human high density lipoprotein 3 ( HDL 3 ) into larger HDL particles and generates lipid poor apoA 1 containing nascent HDL . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Phospholipid transfer protein ( PLTP ) causes proteolytic cleavage of apolipoprotein A 1 . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Using bone marrow transplantation , we assessed the impact of macrophage derived phospholipid transfer protein ( PLTP ) on lesion development in hypercholesterolemic mice that expressed either normal levels of mouse apolipoprotein AI ( apoAI ) or elevated levels of only human apoAI . ^^^ Atheroprotective potential of macrophage derived phospholipid transfer protein in low density lipoprotein receptor deficient mice is overcome by apolipoprotein AI overexpression . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Detergent and chaotropic perturbation of HDL unmasks properties that distinguish apoA 1 from apoA 2 and emulate the secondary effects of lecithin : cholesterol acyltransferase , cholesteryl ester transfer protein , and phospholipid transfer protein the key protein factors in HDL remodeling , that is , formation of lipid free apoA 1 but not apoA 2 and particle fusion . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma fatty acid profiles , lipids , lipoproteins , apolipoprotein A 1 , apolipoprotein B , lipoprotein ( a ) , glucose , insulin , HDL subfractions , and indicators of lipoprotein metabolism ( HDL cholesterol fractional esterification rate , cholesteryl ester transfer protein , phospholipid transfer protein , and paraoxonase activities ) were measured at the end of each phase . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| The process of PLTP mediated HDL enlargement was accompanied by the release of apoproteins , primarily apoA 1 . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Reassembled HDL ( rHDL ) consisting of 1 palmitoyl 2 oleoylphosphatidylcholine , apolipoprotein A 1 , and pyrene lipids ( 100 : 1 : 4 ) were used to demonstrate that PLTP transfers diacylglyceride > phosphatidic acid > sphingomyelin > phosphatidylcholine ( PC ) > phosphatidylglycerol > cerobroside > phosphatidylethanolamine . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| The d < 1 . 22 g / ml fraction produced by PLTP was larger , had lower apolipoprotein A 1 and higher lipid and apolipoprotein A 2 content than native HDL 2 . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| The incubation of reconstituted d HDL preparations containing apo AI with PLTP resulted in the formation of vesicular structures differing in hydrated densities and sizes . ^^^ The d HDL vesicle transformation appeared to be triggered by the PLTP mediated displacement of apo AI . ^^^ The addition of free apo AI to the PLTP / d HDL incubation mixtures also greatly reduced the transformation . ^^^ The conversion of smaller vesicles of density 1 . 07 g ml 1 to larger vesicles of density 1 . 05 g ml 1 also seemed to have been affected by PLTP mediated apo AI displacement . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| On a chow diet , PLTP / mice showed marked decreases in HDL phospholipid ( 60 % ) , cholesterol ( 65 % ) , and apo AI ( 85 % ) , but no significant change in non HDL lipid or apo B levels , compared with wild type littermates . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP did not stimulate lipid efflux in the presence of albumin , purified apolipoprotein A 1 , and phospholipid vesicles , suggesting specificity for HDL particles . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Serum PLTP activity correlated negatively ( r = 0 . 20 , P < 0 . 001 ) with levels of apolipoprotein A 1 in HDL particles that contained only apo A 1 [ Lp ( A 1 ) particles ] . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| The HDL was found to be protein rich ( primarily apoA 1 ) and specifically depleted in phosphatidylcholine ( PC ) ( 28 % in wild type mice ( WT ) vs . 15 % in Pltp KO mice , P < 0 . 001 ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| In contrast , the mRNA levels of the potential regulatory proteins of the HDL level such as apoA 1 , apoE , LCAT , PLTP , SRB 1 and ABC 1 did not change with probucol . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP mass correlated positively with HDL cholesterol ( r = 0 . 36 , P < 0 . 001 ) , apoA 1 ( r = 0 . 37 , P < 0 . 001 ) , apoA 2 ( r = 0 . 20 , P < 0 . 05 ) , Lp ( A 1 ) ( r=0 . 26 , P=0 . 001 ) and Lp ( A I / A 2 ) particles ( r=0 . 34 , P < 0 . 001 ) , and negatively with body mass index ( BMI ) ( r = 0 . 28 , P < 0 . 001 ) and serum triacylglycerol ( TG ) concentration ( r = 0 . 34 , P < 0 . 001 ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| In both groups , HDL lipids , as well as plasma apo AI and PLTP activity decreased after 24 h of insulin ( P < 0 . 05 to P < 0 . 01 ) compared to baseline and recovery , i . e . 1 week after insulin . ^^^ Using plasma from healthy subjects , cholesterol efflux was correlated positively with HDL cholesterol , HDL phospholipids , pre beta HDL in incubated plasma , plasma apo AI and PLTP activity ( P < 0 . 05 to P < 0 . 001 ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| We suggest that the decrease of HDL during the acute phase is caused by reduced LCAT and increased PLTP activities both increasing the plasma levels of lipid poor apoA 1 particles . . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Analysis of the two forms of PLTP by SDS PAGE , Western blotting , immunoprecipitation , and gel filtration demonstrates that LA PLTP is complexed with apoA 1 whereas HA PLTP is not . ^^^ Based on these findings we suggest a model in which nascent PLTP enters the circulation as a high specific activity form not associated with apoA 1 . ^^^ During or after the transfer of lipolytic surface remnants to HDL , PLTP is transferred to apoA 1 containing HDL particles and thereby becomes part of the low activity complex . . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Adjusting for PLTP activity halved the difference between subjects with and without diabetes in apoA 1 ( from 10 . 1 mg / dl higher in subjects with diabetes to 4 . 6 mg / dl higher ) and large HDL ( 2 . 4 micro mol / l higher to 1 . 2 micro mol / l higher ) and reduced the difference in HDL size ( from 0 . 31 nm higher to 0 . 26 nm higher ) . ^^^ Higher PLTP activity was associated with more large HDL ( P < 0 . 001 ) and less small HDL ( P < 0 . 01 ) , more apoAI and apoAII ( both at P < 0 . 001 ) , and more apoAI in both LpAI and LpAIAII ( P = 0 . 02 and P < 0 . 001 , respectively ) . ^^^ These data support the idea that PLTP is a major factor in HDL conversion and remodeling in humans and that higher PLTP activity makes an important contribution to the higher apoAI levels and altered HDL subclass distribution in type 1 diabetes . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP released apolipoprotein A 1 ( apoA 1 ) from HOCl modified HDL 3 , but the particles formed displayed no prebeta mobility . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP coeluted with apolipoprotein E ( apoE ) but not with apoB 100 or apoA 1 . ^^^ Furthermore , antibodies against apoE but not those against apoB 100 or apoA 1 were capable of inhibiting PLTP activity . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP also was detected in an extracellular distribution , colocalizing with apoA 1 , apoB , apoE , and the vascular proteoglycan biglycan . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| We show that 2 fold increased PLTP activity results in ( 1 ) a decrease in HDL cholesterol , HDL phospholipid , and apoAI levels ; ( 2 ) a decrease in vitamin E contents in total plasma and in individual lipoprotein fractions ; ( 3 ) an increase in lipoprotein oxidizability as assessed by copper induced formation of conjugated dienes ; ( 4 ) an increase in autoantibodies against oxidized apoB containing particles ; and ( 5 ) an increase in atherosclerosis lesions in proximal aorta . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Overexpression of ABCA 1 dramatically increased binding of both PLTP and apoA 1 to common sites on the cell surface . ^^^ Both PLTP and apoA 1 were covalently cross linked to ABCA 1 , each protein blocked cross linking of the other , and both PLTP and apoA 1 stabilized ABCA 1 protein . ^^^ These results are consistent with PLTP and apoA 1 binding to ABCA 1 at the same or closely related sites . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| HA PLTP concentration correlated positively with serum PLTPexo activity ( r=0 . 380 , P < 0 . 001 ) , HDL cholesterol ( r=0 . 291 , P < 0 . 001 ) , and apolipoprotein A 1 ( r=0 . 187 , P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| PLTP activity correlated significantly with age , BMI , HbA1c , log ( CRP ) and apolipoprotein AI and B in diabetic subjects . ^^^ General linear model analysis showed that only apolipoprotein AI , age , BMI , and log ( CRP ) were independent determinants of PLTP activity . ^^^ In conclusion , PLTP activity is increased in diabetes and apolipoprotein AI is a major determinant of PLTP activity . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| LA PLTP is associated with apoA 1 while the HA PLTP complex is enriched with apoE . ^^^ These demonstrated a concentration dependent binding of recombinant human PLTP , which represents an active PLTP form , and LA PLTP to apoE , apoA 1 , and apoA 4 within a nanomolar K ( D ) range . ^^^ To study whether LA PLTP can be transformed into an active form , we incubated it in the presence of proteoliposomes containing apoE , apoA 1 or apoA 4 . ^^^ ApoA 4 proteoliposomes also activated LA PLTP in a concentration dependent manner , whereas apoA 1 proteoliposomes had no such effect . ^^^ These observations suggest that PLTP is capable of interacting with apoE , apoA 1 , and apoA 4 , and that these interactions regulate PLTP activity levels in plasma . . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown that apolipoprotein ( apo ) E is involved in maintaining PLTP in the active form , while the low activity form is associated with apo AI . ^^^ We have therefore investigated whether plasma apo AI , B and E concentrations are important determinants of plasma PLTP activity in type 2 diabetes , a condition associated with increased plasma PLTP activity . ^^^ METHODS : Plasma PLTP activity was assayed by measuring the transfer of radiolabelled phosphatidylcholine from liposomes to HDL ; apo AI and B by rate nephelometry and apo E by a 2 point turbidimetric assay . ^^^ CONCLUSIONS : The associations between plasma apo AI and E concentrations and PLTP activity suggest that these apolipoproteins are important regulators of PLTP activity in vivo . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| Such macrophage foam cells from PLTP KO mice released less cholesterol to lipid free apolipoprotein A 1 ( apoA 1 ) and to HDL than did the corresponding WT foam cells . ^^^ After cAMP treatment , which upregulated the expression of ABCA 1 , cholesterol efflux from PLTP KO foam cells to apoA 1 increased markedly and reached a level similar to that observed in cAMP treated WT foam cells , restoring the decreased cholesterol efflux associated with PLTP deficiency . ^^^ |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55058 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|