| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.69804254 |
| The possibility of a direct interaction between CETP and the two major HDL apolipoproteins , apoA 1 and apoA 2 , was further investigated by combining crosslinking and immunoblotting techniques . 0.69804254^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The role of cholesteryl ester transfer protein in primate apolipoprotein A 1 metabolism . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effect of the cholesteryl ester transfer protein ( CETP ) on the size redistribution of high density lipoprotein 3 ( HDL 3 ) particles containing either apolipoprotein A 1 without apolipoprotein A 2 , designated HDL 3 ( A 1 w / o A 2 ) , or apolipoprotein A 1 with apolipoprotein A 2 , designated HDL 3 ( A 1 w A 2 ) , was investigated by incubating HDL 3 at 37 degrees C in the presence of a purified preparation of CETP . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| An interaction between the human cholesteryl ester transfer protein ( CETP ) and apolipoprotein A 1 genes in transgenic mice results in a profound CETP mediated depression of high density lipoprotein cholesterol levels . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We describe now the properties of Bsol 7 as a marker of LDL oxidation in whole plasma in relation to other effects of oxidative treatment of plasma , such as the distribution of apoA 1 and cholesteryl ester transfer protein ( CETP ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Genetic variation in the cholesteryl ester transfer protein and apolipoprotein A 1 genes and its relation to coronary heart disease in a Sri Lankan population . ^^^ The influence of variation in the genes for cholesteryl ester transfer protein and apolipoprotein A 1 was investigated in 95 patients with coronary heart disease and 95 matched control subjects of South East Asian extraction . ^^^ Restriction fragment length polymorphisms ( RFLPs ) linked to the cholesteryl ester transfer protein gene TaqIA and TaqIB , and to the apolipoprotein A 1 gene SstI , were examined to investigate the extent of genetic variation at these loci . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| ApoJ exists in the plasma associated with high density lipoproteins ( HDL ) and specifically with subclasses of HDL which also contain apoAI and cholesteryl ester transfer protein activity . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The incubation of mixtures of HDL 3 and chylomicrons enriched with apoAI in the presence of lecithin : cholesterol acyltransferase and cholesteryl ester transfer protein caused the formation of HDL 2 like particles which resembled those of native HDL 2 also with respect to the apoAI / AII ratio . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Suggested mechanisms for reduced HDL levels in FH patients have been altered apolipoprotein A 1 metabolism and elevated cholesteryl ester transfer protein activity , but the molecular basis for hypoalphalipoproteinemia in any of these patients has not yet been identified . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Ultracentrifugally isolated HDL subclasses ; concentrations of apoA 1 , apoA 2 , LpA 1 and LpA 1 : A 2 particles ; post heparin plasma lipoprotein lipase ( LPL ) , hepatic lipase ( HL ) and plasma cholesteryl ester transfer protein ( CETP ) activities ; phospholipid transfer protein ( PLTP ) and lecithine cholesteryl acyltransferase ( LCAT ) activities were measured in plasma from six patients from both groups . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| It has been shown previously that the reduction in particle size of HDL which follows incubation with the cholesteryl ester transfer protein ( CETP ) plus very low density lipoproteins ( VLDL ) or low density lipoproteins ( LDL ) is accompanied by the dissociation of lipid free apolipoprotein A 1 ( apo A 1 ) from HDL . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Structural and functional differences of subspecies of apoA 1 containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms at the apoB , apoA 1 , and cholesteryl ester transfer protein gene loci in patients with gallbladder disease . ^^^ Restriction fragment length polymorphisms ( RFLPs ) of apolipoprotein B ( XbaI , EcoRI ) , apolipoprotein A 1 ( PstI , MspI ) , and cholesteryl ester transfer protein ( CETP ) ( EcoNI , TaqIA , TaqIB ) genes were examined in a series of 210 cholecystectomy patients operated on for symptomatic gallbladder disease and in 92 healthy controls . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We examined restriction fragment length polymorphisms associated with the cholesteryl ester transfer protein gene and the apolipoprotein AI gene in a group of 60 unrelated subjects selected from an initial survey of 5000 subjects on the basis of their high density lipoprotein levels being high or low at the extremes of the distribution . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Level gene effect with respect to apolipoprotein A 1 ( apoA 1 ) and high density lipoprotein ( HDL ) cholesterol as well apparent variability gene effect with respect to total and LDL cholesterol were detected with a DNA polymorphism at the cholesteryl ester transfer protein ( CETP ) locus . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Human apoA 4 , apoA 1 , apoE , and cholesteryl ester transfer protein were assessed for their ability to increase LPL activity in the presence of VLDL . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effect of apolipoprotein ( apo ) composition of high density lipoproteins ( HDL ) on cholesteryl ester transfer protein ( CETP ) activity was studied by measuring the rate of radiolabeled cholesteryl esters transferred between low density lipoproteins ( LDL ) and HDL 3 which contained various proportions of apoAI and apoAII . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein A 1 metabolism in cholesteryl ester transfer protein transgenic mice . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| For these analyses we cloned partial rabbit cDNAs for apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , apolipoprotein E ( apoE ) , cholesteryl ester transfer protein ( CETP ) , hepatic lipase ( HL ) , lipoprotein lipase ( LPL ) , HMG CoA reductase , LDL receptor , 7 alpha hydroxylase , albumin , bile salt dependent cholesteryl ester hydrolase ( CEH ) , lecithin : cholesterol acyl transferase ( LCAT ) , and plasminogen activator inhibitor protein 1 ( PAI 1 ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Deficiency of the cholesteryl ester transfer protein ( CETP ) in humans is characterized by markedly elevated plasma concentrations of HDL cholesterol and apoA 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The apoC 1 fragment and modified apoA 1 presented at equimolar concentrations exhibited similar inhibition of cholesteryl ester transfer protein ( CETP ) activity in HDL of low HDL 1 baboons . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Evaluation of G to A substitution in the apolipoprotein A 1 gene promoter as a determinant of high density lipoprotein cholesterol level in subjects with and without cholesteryl ester transfer protein deficiency . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Transcriptional regulation of the cholesteryl ester transfer protein gene by the orphan nuclear hormone receptor apolipoprotein AI regulatory protein 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Nor was there dissociation of apoA 1 when the HDL were incubated either with the cholesteryl ester transfer protein ( CETP ) in the absence of other lipoprotein fractions or with other lipoproteins in the absence of CETP . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| These genes include those encoding various apolipoproteins ( apo ) , including apoA 1 , apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , apoE , and apo ( a ) , cholesteryl ester transfer protein ( CETP ) , HDL binding protein , lipoprotein lipase , and the low density lipoprotein ( LDL ) receptor . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| ApoA 1 defined particles ( LpAs ) were assessed for their content of cholesteryl ester transfer protein ( CETP ) and for their ability to act as substrates for CETP . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Function of apolipoprotein ( apo ) A 4 was studied for its role in cholesteryl ester transfer protein ( CETP ; lipid transfer protein , LTP ) reaction between lipid microemulsions having the diameter of low density lipoprotein , being compared to apoA 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effect of fenofibrate on plasma cholesteryl ester transfer protein ( CETP ) activity in relation to the quantitative and qualitative features of apoB and apoA 1 containing lipoprotein subspecies was investigated in nine patients presenting with combined hyperlipidemia . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We have now used this experimental system to study the selective effects of two human lipoprotein related proteins , apoprotein AI ( apo AI ) and cholesteryl ester transfer protein ( CETP ) on cell cholesterol efflux , when these proteins are expressed in transgenic mice . ^^^ Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and / or human apolipoprotein AI . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Increased prebeta HDL levels , cholesterol efflux , and LCAT mediated esterification in mice expressing the human cholesteryl ester transfer protein ( CETP ) and human apolipoprotein A 1 ( apoA 1 ) transgenes . ^^^ The effects of cholesteryl ester transfer protein ( CETP ) on the distribution of apolipoprotein ( apo ) A 1 between high density lipoprotein ( HDL ) subspecies and its impact on efflux and esterification of cell derived cholesterol was studied in transgenic mice expressing either the human apoA 1 ( HuAITg ) or both the human apoA 1 and CETP ( HuAICETPTg ) transgenes . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Studies in humans have established that mutations in genes encoding enzymes that esterify cholesterol ( lecithin : cholesterol acyltransferase ) , transfer cholesterol ( cholesteryl ester transfer protein ) and hydrolyze lipids ( hepatic lipase , lipoprotein lipase ) regulate HDL cholesterol and apolipoprotein A 1 levels by modifying the lipid content ( and therefore the size ) of HDL particles . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Since previous studies have shown that human cholesteryl ester transfer protein and lecithin : cholesterol acyltransferase only function optimally in human apoAI transgenic mice , the human PLTP transgenic mice were cross bred with human apoAI transgenic mice . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non smoking healthy men , and the effect on plasma HDL cholesterol and apoAI concentration . ^^^ Three hundred and sixteen healthy Icelandic men and women were examined for the effect of the cholesteryl ester transfer protein ( CETP ) I405V polymorphism on plasma triglycerides , HDL cholesterol ( HDLC ) and apoAI concentration . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We examined common polymorphisms in the genes encoding the LDL receptor , lipoprotein lipase , apoAI , apoB , apoAIV and cholesteryl ester transfer protein and related them to changes in LDL and HDL cholesterol after high fat / high cholesterol diets . 2 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma high density lipoproteins ( HDLs ) from humans , from transgenic mice to human apolipoprotein A 1 ( HuAITg mice ) , from transgenic mice to human apolipoprotein A 2 ( HuAIITg mice ) , from transgenic mice to human apolipoproteins A 1 and A 2 ( HuAIAIITg mice ) , and from C57BL / 6 control mice were isolated , and their ability to interact with the human cholesteryl ester transfer protein ( CETP ) was studied . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| In order to define the active domain for lipid binding in CETP ( cholesteryl ester transfer protein ) , our study discusses some fundamental physicochemical properties of this molecule such as hydrophobic moment , protein active surface and helix amphipathicity , in comparison to the properties reported for a series of apoproteins including apoAI , apoAII , apoCI , CII , CIII and apoE . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effect of the apolipoprotein E phenotype on cholesteryl ester transfer protein activity , plasma lipids and apolipoprotein A 1 levels in hypercholesterolaemic patients on colestipol and lovastatin treatment . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Apolipoprotein J ( apoJ , protein ; APOJ , gene ) is found in serum associated with high density lipoprotein ( HDL ) subfractions , which also contain apolipoprotein A 1 ( apoA 1 ) and cholesteryl ester transfer protein . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Additional implicated loci include lipoprotein lipase , apolipoprotein CII , cholesteryl ester transfer protein , apolipoprotein AI , and lecithin cholesterol acyl transferase . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Cholesteryl ester transfer protein mediated the dissociation of apoA 1 more readily from reconstituted HDL containing apoA 1 ( +32 ) than unoxidized apoA 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Genetic variants at the cholesteryl ester transfer protein ( CETP ) locus have been associated with CETP activity and mass , as well as plasma high density lipoprotein cholesterol ( HDL C ) and apolipoprotein A 1 levels . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The effects of common variants of cholesteryl ester transfer protein ( CETP ) ( TaqIB ) , hepatic lipase ( HL ) ( 514C > T ) , lipoprotein lipase ( LPL ) ( S447X ) and lecithin cholesterol acyl transferase ( LCAT ) ( S208T ) on the determination of high density lipoprotein cholesterol ( HDL C ) and apolipoprotein AI ( apoAI ) levels were examined in 2773 healthy middle aged men participating in the second Northwick Park Heart Study . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Pre beta apoA 1 is formed when plasma factors , such as cholesteryl ester transfer protein ( CETP ) , remodel high density lipoproteins ( HDL ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The inverse correlation of apoA 1 distribution ( relative concentration ) between alpha 1 and alpha 3 suggests an interconversion of alpha 1 and alpha 3 subpopulations , possibly by cholesteryl ester transfer protein . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| When pig HDL were enriched with TG by incubation with cholesteryl ester transfer protein ( CETP ) and very low density lipoproteins , the TG / apoA 1 molar ratio increased from 0 . 7 / 1 to 11 . 4 / 1 and the diameter increased from 9 . 0 to 9 . 5 nm . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| To investigate the effect of thyroid dysfunction on high density lipoprotein ( HDL ) metabolism , we measured HDL subfractions , apolipoprotein A 1 containing particles ( LpA 1 and LpA 1 : A 2 ) , and the activities of enzymes involved in the remodeling and metabolism of HDL [ namely hepatic lipase ( HL ) , lipoprotein lipase , and cholesteryl ester transfer protein ( CETP ) ] in 18 hyperthyroid and 17 hypothyroid patients before and after treatment . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Variation at the cholesteryl ester transfer protein ( CETP ) gene locus has been implicated in determining the levels and activity of CETP , apoAI and high density lipoprotein ( HDL ) plasma concentration and the risk of developing coronary artery disease . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| This study was aimed to examine cholesteryl ester transfer protein ( CETP ) , apolipoprotein AI and CIII gene polymorphisms , and to verify whether these genetic determinants are associated with the prevalence of myocardial infarction ( MI ) or type 2 diabetes . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Pharmacological inhibition of the cholesteryl ester transfer protein ( CETP ) in humans increases high density lipoprotein ( HDL ) cholesterol ( HDL C ) levels ; however , its effects on apolipoprotein A 1 ( apoA 1 ) containing HDL subspecies , apoA 1 turnover , and markers of reverse cholesterol transport are unknown . ^^^ Effects of cholesteryl ester transfer protein inhibition on high density lipoprotein subspecies , apolipoprotein A 1 metabolism , and fecal sterol excretion . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Fortuitously , we were able to directly compare carotid intima media thickness data of substantial numbers of individuals with mutations in either apolipoprotein A 1 ( apoA 1 ) , ATP binding cassette AI ( ABCA 1 ) , lecithin : cholesterol acyltransferase ( LCAT ) or cholesteryl ester transfer protein . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| HDL cholesterol , apolipoprotein A 1 and Lp ( a ) concentrations and cholesteryl ester transfer protein and lecithin : cholesterol acyl transferase activities were also not significantly altered . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Three plausible candidate mechanisms are identified : ( 1 ) antioxidant stimulation of cholesteryl ester transfer protein expression / activity , ( 2 ) antioxidant suppression of macrophage ATP binding cassette transmembrane transporter A 1 expression , and / or ( 3 ) antioxidant suppression of hepatic or intestinal apolipoprotein A 1 synthesis or increase in apolipoprotein A 1 catabolism . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| In a subgroup of 13 subjects with impaired glucose tolerance , cholesteryl ester transfer protein activity correlated with HDL apoA 1 fractional catabolic rate ( r=0 . 701 , p < 0 . 01 ) . ^^^ In normoglycemic subjects , significant correlations were found only between cholesteryl ester transfer protein activity and percentage of HDL triglycerides ( r=0 . 541 , p < 0 . 05 ) , percentage of HDL cholesteryl ester ( r= 0 . 639 , p < 0 . 01 ) , 2 h proinsulin ( r=0 . 642 , p < 0 . 05 ) , and HDL apoA 1 fractional catabolic rate ( n=10 , r=0 . 587 , p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Emerging HDL raising therapies ( such as cholesteryl ester transfer protein inhibitors and 1 , 2 dimyristoyl sn glycero phosphocholine ) and novel interventions that mimic HDL ' s beneficial effects ( such as apolipoprotein AImilano and apolipoprotein AI mimetic peptides ) are proving beneficial in animal and human studies . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Amongst the processes involved in the reverse cholesterol transport ( RCT ) from organs to liver , including high density lipoproteins apolipoprotein AI ( HDL apoAI ) dependent tissue uptake and cholesteryl ester transfer protein ( CETP ) mediated transfers , the selective uptake of cholesteryl ester ( CE ) is of increasing interest through its antiatherogenic role . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Detergent and chaotropic perturbation of HDL unmasks properties that distinguish apoA 1 from apoA 2 and emulate the secondary effects of lecithin : cholesterol acyltransferase , cholesteryl ester transfer protein , and phospholipid transfer protein the key protein factors in HDL remodeling , that is , formation of lipid free apoA 1 but not apoA 2 and particle fusion . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma fatty acid profiles , lipids , lipoproteins , apolipoprotein A 1 , apolipoprotein B , lipoprotein ( a ) , glucose , insulin , HDL subfractions , and indicators of lipoprotein metabolism ( HDL cholesterol fractional esterification rate , cholesteryl ester transfer protein , phospholipid transfer protein , and paraoxonase activities ) were measured at the end of each phase . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Emerging targets involved in HDL metabolism are : ( 1 ) liver 10 receptor and peroxisome proliferator activated receptor agonists ; ( 2 ) cholesteryl ester transfer protein inhibitors ; ( 3 ) HDL mimetics ( ETC 216 ) ; ( 4 ) apolipoprotein A 1 synthetic peptides ; and ( 5 ) HDL delipidation and reinfusion . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| In this brief review , we propose that spherical apoAI is derived from HDL by remodeling events that are accomplished by proteins secreted by cholesteryl ester loaded foam cells , including the lipid transfer proteins , phospholipid transfer protein , and cholesteryl ester transfer protein , and the triglyceride hydrolases hepatic lipase and lipoprotein lipase . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma cholesteryl ester transfer protein ( CETP ) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B ( apoB ) containing lipoproteins when it is expressed in combination with human apoA 1 in HuAI / CETP transgenic ( Tg ) rodents . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Conventional and new pharmacological treatments , such as statins , fibrates and cholesteryl ester transfer protein inhibitors , can also correct dyslipidemia by several mechanisms , including decreased secretion and increased catabolism of apolipoprotein B , as well as increased secretion and decreased catabolism of apolipoprotein A 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| A well characterized cohort of 546 Caucasian men with documented coronary artery disease was genotyped for common functional variants in genes that control reverse cholesterol transport : ATP binding cassette transporter A 1 , apolipoprotein A 1 and apolipoprotein E , cholesteryl ester transfer protein , hepatic lipase , lecithin : cholesterol acyl transferase , lipoprotein lipase , and scavenger receptor class B type 1 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The new and emerging drug therapies include an antiobesity agent that reduces atherogenic dyslipidemia and abnormal glucose metabolism ; cholesteryl ester transfer protein inhibitors that increase HDL cholesterol and apoA 1 levels ; glitazars that increase HDL cholesterol and decrease triglyceride concentrations , as well as improve abnormal glucose metabolism ; and the amylin analog pramlintide and the incretin mimetic exenatide , both of which reduce body weight as well as improve abnormal glucose metabolism . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Therapeutic normalization of attenuated antiatherogenic HDL function in terms of both particle number and quality of HDL particles is the target of innovative pharmacological approaches to HDL raising , including inhibition of cholesteryl ester transfer protein , enhanced lipidation of apoA 1 with nicotinic acid and infusion of reconstituted HDL or apoA 1 mimetics . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Novel targets for atherosclerotic intervention include inhibitors of cholesterol synthesis and absorption such as acyl coenzyme A : cholesterol acyltransferase , acyl coenzyme A : diacylglycerol acyltransferase and cholesteryl ester transfer protein inhibitors , potential novel antioxidants other than anti inflammatory peroxisome proliferator activated receptor agonists , and apolipoprotein A 1 mimetic peptides . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Based on these findings , we propose a cyclical model in which 1 ) apoA 1 mass moves from pre beta HDL to alpha HDL in connection with the action of LCAT and the generation of cholesteryl esters within the HDL , and 2 ) apoA 1 moves from alpha HDL to pre beta HDL in connection with the action of CETP and the movement of cholesteryl esters out of the HDL . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| To detect the associations between the CETP polymorphisms and serum lipid and apoprotein levels , we determined the serum concentrations of total cholesterol , triglycerides , high density lipoprotein ( HDL ) cholesterol , apoA 1 , apoA 2 and apoB in the subjects studied and correlated them to the 3 RFLPs . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The parenchymal and nonparenchymal cells were separated by standard methods , and the CETP , apoA 1 , apoB , and apoE mRNA content of the preparation determined at each step in the purification process . ^^^ The mRNA measurements showed that the CETP mRNA : apoA 1 mRNA and the CETP mRNA : apoB mRNA ratios were more than 2500 fold greater in the nonparenchymal cell preparation than in the starting material , and that the purified parenchymal cell fraction was virtually devoid of CETP mRNA . ^^^ In situ hybridization studies showed that , whereas the apoA 1 mRNA signal was evenly distributed over the tissue section , the CETP mRNA signal was associated with the hepatic sinusoids , suggesting that it was the hepatic sinusoidal cells that were principally responsible for the high CETP mRNA levels in the liver . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Family members homozygous for CETP deficiency ( n = 10 ) had moderate hypercholesterolemia ( mean total cholesterol level [ + / SD ] , 7 . 01 + / 0 . 83 mmol per liter ) , markedly increased levels of HDL cholesterol ( 4 . 24 + / 1 . 01 mmol per liter ) and apolipoprotein A 1 , and decreased levels of low density lipoprotein cholesterol ( 1 . 99 + / 0 . 80 mmol per liter ) and apolipoprotein B . ^^^ Members heterozygous for the deficiency ( n = 20 ) , whose CETP levels were in the lower part of the normal range , had moderately increased levels of HDL cholesterol and apolipoprotein A 1 and an increased ratio of HDL subclass 2 to HDL subclass 3 , as compared with unaffected family members ( 1 . 5 + / 0 . 8 vs . 0 . 7 + / 0 . 4 ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The distribution of CETP between these two states was influenced by the presence of apoA 1 or albumin , incubation time , vesicle / CETP ratio , and buffer pH and ionic strength . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Humans with genetic deficiency of CETP have both elevated HDL cholesterol and apolipoprotein A 1 concentrations as well as decreased LDL cholesterol and apolipoprotein B levels . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| LPS was injected into mice expressing ( A ) a human apoA 1 transgene , ( B ) apoA 1 and NFR CETP transgenes , or ( C ) apoA 1 and LPS inducible metallothionein promoter driven CETP transgenes , producing ( A ) minimal changes in HDL cholesterol , ( B ) decreased plasma CETP and increased HDL cholesterol , and ( C ) increased plasma CETP and decreased HDL cholesterol . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| To understand the mechanism of interaction of CETP with HDL , we studied the binding of pure recombinant CETP to 1 palmitoyl 2 oleoylphosphatidylcholine ( POPC ) / apoA 1 discoidal particles . ^^^ At lower ratios of CETP to discs , CETP bound to discs without displacement of apoA 1 . ^^^ Cross linking of CETP to apoA 1 in discs suggested proximity of apoA 1 and CETP . ^^^ For POPC / apoA 1 discs , 10 nm discs bound CETP with much higher affinity than smaller 7 . 8 nm discs ( Kd = 1 2 microM ) . 7 . 7 nm hydrodynamic diameter POPC / apoA 1 spherical particles containing either triolein or cholesteryl oleate in their core bound CETP with higher affinity ( Kd = 50 100 nM ) than 7 . 8 nm POPC / apoA 1 discs . ^^^ Thus , CETP appears to bind to the perimeter of discoidal particles , possibly in a process in which flexible segments in apoA 1 or apoA 2 accommodate CETP at the disc edge . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| It is concluded that CETP converts rHDL to small , TG enriched , apoA 1 depleted particles with increased lipid water interfacial hydration and less ordered phospholipid packing . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Studies in transgenic mice show that CETP expression results in decreased levels of HDL cholesterol , but that the effects of CETP on HDL apolipoprotein A 1 ( apoA 1 ) content and size show important modulation by co expression with transgenes encoding human apoA 1 , apoC 3 and apoA 2 . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Second , transgenic mice model provides relevant insights into lipoprotein metabolism : the structural role of human apo AII , the effect of apo AI on HDL subfractions distribution , the contribution of apo CIII to hypertriglyceridemia , and by contrast of apo E in the clearance of atherogenic TG rich lipoproteins , the role of CETP in the balance of LDL and HDL concentration and distribution . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We isolated and characterized the apoA 1 containing lipoprotein particles from three subjects with homozygous CETP deficiency ( CETP D ) and compared the results with those from normolipidemic control subjects . ^^^ Plasma concentrations of apoA 1 in both LpA 1 and LpA 1 : A 2 were significantly elevated in CETP D subjects . ^^^ The molar ratio of apoA 1 to apoA 2 in LpA 1 : A 2 isolated from CETP D subjects was higher ( mean 2 . 4 ) than those of controls ( mean 1 . 4 ) . ^^^ These data suggest that the absence of CETP in humans significantly affects the plasma concentration , size , composition , and cellular interaction of both major classes of apoA 1 containing lipoprotein particles . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| To investigate a possible modulation of the effects of CETP by apoA 2 , human CETP transgenic mice were cross bred with transgenic mice expressing human apoA 2 and , in some cases , human apoA 1 and apoC 3 ( with human like HDL and hypertriglyceridemia ) . ^^^ CETP expression resulted in reductions of HDL and increases in VLDL cholesteryl ester in mice expressing human apoA 2 , alone or in combination with apoA 1 and apoC 3 , indicating that apoA 2 does not inhibit the cholesteryl ester transfer activity of CETP . ^^^ CETP expression caused dramatic reductions in HDL size and apoA 1 content in apoAI CIII transgenic mice , but not in apoA II / AI CIII transgenic mice . ^^^ However , coexpression of apoA 2 with CETP results in HDL particles that are more triglyceride enriched and resistant to reductions in size and apoA 1 content , reflecting inhibition of hepatic lipase by apoA 2 . ^^^ However , CETP expression resulted in more prominent increases in HDL triglyceride in mice expressing both apoA 2 and CETP , especially in CETP / apoA II / apoAI CIII transgenic mice . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that neither the concentration of HDL C or apolipoprotein AI nor the level of CETP activity dictates the magnitude of centripetal cholesterol flux from the extrahepatic organs to the liver , at least in the mouse . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We have studied a 49 year old Japanese male presenting with total cholesterol , HDL cholesterol , and apolipoprotein A 1 levels of 300 , 236 , and 233 mg / dl , respectively , and total absence of CETP activity and mass in plasma . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We found that HDL2b was 2 . 4 times higher in CETP deficiency than in control [ 52 . 2 + / 14 . 3 , vs . 21 . 5 + / 9 . 8 % of plasma apoA 1 ( % AI ) , p < 0 . 005 ] while HDL2a and HDL 3 were significantly lower in the former than in the latter ( HDL2a ; 25 . 5 + / 8 . 0 vs . 40 . 4 + / 6 . 5 % AI , p < 0 . 005 ) ( HDL 3 ; 10 . 0 + / 6 . 8 vs . 28 . 3 + / 5 . 9 % AI , p < 0 . 005 ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| When linked to a human apoA 1 transgene , the 570 to 138 segment of the CETP gene promoter gave rise to a relative positive response of hepatic apoA 1 mRNA to the high cholesterol diet in two out of three transgenic lines . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma CETP activities , plasma total apoA 1 and prebeta apoA 1 concentrations in the HC group were significantly increased ( 58 . 95 + / 2 . 37 % , 191 . 52 + / 13 . 93 mg / dl , 44 . 21 + / 1 . 14 mg / dl , respectively ) compared with the LC group ( 39 . 36 + / 3 . 62 % , 152 . 85 + / 8 . 61 mg / dl , 30 . 12 + / 2 . 79 mg / dl , respectively ) ( p < 0 . 05 ) . ^^^ Hepatic CETP , LCAT and apoA 1 mRNA levels were determined using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Hepatic CETP mRNA levels , compared to GAPDH mRNA levels as a control , were increased in the HC group ( 2 . 226 + / 0 . 115 ) compared with the LC group ( 1 . 649 + / 0 . 170 ) ( p < 0 . 05 ) , while hepatic LCAT and apoA 1 mRNA levels were unchanged . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The KKAy CETP mice retained the principal characteristics of KKAy mice except that their plasma HDL levels were reduced ( from 159 + / 25 to 25 + / 6 mg / dl ) and their free apolipoprotein A 1 concentrations increased ( from 7 + / 3 to 22 + / 6 mg / dl ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| HDL cholesterol , serum apo AI and serum CETP activity levels were very similar in alcohol users compared to abstainers ( 1 . 36 + / 0 . 28 vs 1 . 36 + / 0 . 36 mmol l 1 , 1 . 71 + / 0 . 31 vs 1 . 75 + / 0 . 33 g l 1 and 134 + / 27 vs 138 + / 53 nmol l 1h 1 , respectively , n . s . for all ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Genes shown to affect risk factors or protective factors with respect to coronary heart disease ( CHD ) have been identified at the APOB , APOAI , LPA , LDLR , APOE and CETP loci . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| However , apoA 1 overexpression has more dramatic protective effects on atherosclerosis in apoE 0 mice , which are not significantly reversed by concomitant expression of CETP . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Other loci , including APOA 4 , APOA 1 , APOB , APOC 3 , LPL and CETP have also been found to account for some of the variability in the fasting and fed states . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We carried out HDL CE turnover studies in mice expressing human CETP and / or human lecithin : cholesterol acyltransferase ( LCAT ) transgenes on a background of human apoA 1 expression . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Hepatic levels of apoA 1 mRNA in coconut oil fed animals were elevated 150 % after 4 weeks compared to chow fed controls ; hepatic mRNA levels for ten other genes either decreased slightly ( apoB , LCAT , hepatic lipase , albumin , ACAT , and HMG CoA reductase ) or were unchanged ( CETP , apoE , LDL receptor , and acyl CoA oxidase ) . ^^^ Nuclear run on transcription assays revealed that coconut oil feeding for 4 weeks caused a 220 % increase in hepatic apoA 1 transcription rate compared to controls ; no change was observed for CETP and apoE . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Among other factors , apoA 1 , cholesterol ester transfer protein ( CETP ) , scavenger receptor B 1 ( SR B 1 ) , and hepatic lipase are potential candidates that modulate plasma levels of HDL . ^^^ Since estrogen treatment increased hepatic apoA 1 mRNA and apoA 1 synthesis , and mouse express undetectable levels of CETP , we tested the hypothesis that estradiol mediated lowering of HDL in mice may occur through modulation of hepatic lipase ( HL ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| An absence of cholesterol ester transfer protein ( CETP , protein ; CETP , gene ) results in an increase of the apolipoprotein AI levels and a decrease in the low density lipoprotein ( LDL ) levels . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The B 2 allele was associated in a dose dependent fashion with higher HDL cholesterol and apolipoprotein AI levels , together with lower CETP concentrations . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Linkage analyses showed that this major gene was not located in chromosomal regions that contain six candidate genes whose protein products are important to HDL metabolism ( LCAT , CETP , APOA 1 , APOE , ABCA 1 , LIPC ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The patients with gene mutation had decreased plasma CETP concentration , while increased concentration of HDL C and apolipoprotein A 1 compared with controls . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| We also confirmed the following associations : 1 ) the apo AII / MspI with Tg level ; 2 ) the apo CIII / SstI with Tg , TC , and apo B levels ; 3 ) the Apo E / HhaI E 2 , E 3 , and E 4 alleles with TC , apo AI , and apo B levels ; and 4 ) the CETP / TaqIB with apo AI level . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| However , addition of apoA 1 or B antibody to a CETP inhibition mixture decreased the inhibitory activity of P 28 by ca . 20 % . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Furthermore , as a consequence of the downregulation of CETP , the expression of scavenger receptor class B type 1 ( SR BI ) , an HDL receptor , was also reduced by approximately 50 % in mRNA and protein levels , whereas the apolipoprotein A 1 ( apoA 1 ) expression and secretion were increased by 30 and 92 % , respectively . ^^^ Taken together , these findings suggest that although acute suppression of CETP expression leads to an elevation in cellular cholesterol stores , apoA 1 secretion , and cellular cholesterol efflux to apoA 1 , the return of HDL CE to hepatocytes via an SR BI pathway was inhibited in vitro . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| The aim of this study is to determine whether lipid poor apoA 1 is also formed when ( A I / A 2 ) rHDL are remodeled by CETP . ^^^ Spherical reconstituted HDL that were identical in size had comparable lipid / apolipoprotein ratios and either contained apoA 1 only , ( A 1 ) rHDL , or ( A I / A 2 ) rHDL were incubated for 0 24 h with CETP and Intralipid ( R ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Recent data suggest that potentially important targets for upregulating HDL in humans include upregulators of ABCA 1 and APOA 1 ( e . g . peroxisome proliferator activated receptor and liver 10 receptor agonists ) and downregulators of CETP ( e . g . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Current approaches to increasing HDL to determine the efficacy of HDL in reducing atherosclerosis involve acute HDL therapy with infusions of apoA 1 or apoA 1 mimetic peptides and chronic long term therapy with selective agents to increase HDL , including CETP inhibitors . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Major constituents of RCT include acceptors such as high density lipoprotein ( HDL ) and apolipoprotein A 1 ( apoA 1 ) , and enzymes such as lecithin : cholesterol acyltransferase ( LCAT ) , phospholipid transfer protein ( PLTP ) , hepatic lipase ( HL ) and cholesterol ester transfer protein ( CETP ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Correlation analysis showed that CETP activity was significantly correlated with the HDL C to apoA 1 ratio ( r = 0 . 205 , P = 0 . 003 ) and to LDL C to HDL C ratio in diabetic women ( P = 0 . 010 ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Incubation of the apoE containing spherical rHDL with CETP and Intralipid ( R ) generated large fusion products without the dissociation of apoE , whereas the spherical ( A 1 ) rHDLs were remodeled into small particles with the formation of lipid poor apoA 1 . ^^^ In conclusion , 1 ) apoE activates LCAT less efficiently than apoA 1 ; 2 ) apoE containing spherical rHDLs are structurally distinct from spherical ( A 1 ) rHDL ; and 3 ) the CETP mediated remodeling of apoE containing spherical rHDL differs from that of spherical ( A 1 ) rHDL . . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| Overproduction of VLDL leads to increased plasma levels of TG which , via an exchange process mediated by cholesterol ester transfer protein ( CETP ) , results in low levels of high density lipoprotein ( HDL ) cholesterol and apolipoprotein A 1 , and the generation of small , dense , cholesterol ester depleted low density lipoproteins ( LDL ) . ^^^ |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11597 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|