Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.51919961
OBJECTIVE : To evaluate the association between Apolipoprotein AI ( ApoAI ) , Apolipoprotein B 100 ( ApoB ) and the presence of lower limb atherosclerotic occlusive disease . 0.51919961^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.54091933
Plasma cholesteryl ester transfer protein ( CETP ) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B ( apoB ) containing lipoproteins when it is expressed in combination with human apoA 1 in HuAI / CETP transgenic ( Tg ) rodents . 0.54091933^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma TGs and FFA were increased in AIDS , while plasma cholesterol , high density lipoprotein ( HDL ) cholesterol , apolipoprotein A 1 ( Apo A 1 ) , low density lipoprotein ( LDL ) cholesterol , and Apo B 100 levels were decreased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In relationship to age and sex , in males , as age increases , there is an elevation in LDL C and TG and a diminution in T C , HDL C , Apo AI and Apo B 100 . ^^^ In females , there is a diminution in LDL C , TG , Apo B 100 and an increase in HDL C , Apo AI and T C , with the increase in T C being found only in those older than 15 years . . ^^^ We determined the lipid profile : total cholesterol ( T C ) , cholesterol bound to high density lipoproteins ( HDL C ) , cholesterol bound to low density lipoproteins ( LDL C ) , cholesterol bound to very low density lipoproteins ( VLDL C ) , triglycerides ( TG ) , apolipoprotein AI and apolipoprotein B 100 ( Apo A 1 and Apo B 100 , respectively ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Addition of sodium butyrate to the culture medium of the human hepatoma cell line Hep G 2 resulted in a time and dose dependent increase in the secretion of apolipoprotein A 1 ( apo A 1 ) and apolipoprotein B 100 ( apo B 100 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Blood samples for serum total cholesterol ( TC ) , high density lipoproteins ( HDL C ) , low density lipoproteins ( LDL C ) , triglycerides ( TG ) , TC / HDL C ratio , apolipoprotein A 1 ( apo A 1 ) , and apolipoprotein B 100 ( apo B 100 ) were obtained pre , and after 4 , 8 , and 12 wk of training and approximately 3 4 d following the last training session . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Results show that there are no apo B 100 , CII or trace apo CIII in human cerebrospinal fluid , the levels of apo AI in cerebrospinal fluid are 1 . 00 + / 0 . 54 mg / dl with a range of 0 . 35 2 . 00 mg / dl and the apo E content is 0 . 69 + / 0 . 16 mg / dl with a range of 0 . 51 0 . 99 mg / dl . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The perfusate [ 35S ] S labelled apoproteins ( apo B 100 , B 48 ; apo E , apo AI , apo AIV and apo C ) were separated by gel electrophoresis and identified by autoradiography . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apo AI was slightly decreased and apo B 100 slightly increased in the apoplectics compared with normal subjects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have developed a simple , rapid assay method to measure remnant like lipoproteins by using an immunoaffinity gel mixture of anti apo B 100 and apoA 1 antibodies to Sepharose 4B . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein A 1 was decreased ( P < 0 . 05 ) , but apo B 100 was increased ( P < 0 . 01 ) in the patients with hypertension which indicated that the change of apolipoprotein could be a factor for patients with hypertension and sensitive to CHD . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol , high density lipoprotein ( HDL ) cholesterol , apolipoprotein A 1 ( apo ) A 1 , apo B 100 , and lipoprotein ( a ) were measured before and after 14 wk of treatment with beta carotene ( 20 mg / d , n = 25 ) or placebo ( n = 25 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The most affected apolipoproteins ( apo ) were apo B 100 and apo B 48 in rats fed on protein deficient diets , apo AI and apo E in the COd group , and apo AIV in the SAd group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Enzyme linked immunoassays were used to quantify apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , apoE and apo B 100 in Lp [ a ] and autologous LDL isolated from three healthy males . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The changes in apo B 100 after oral glucose ingestion decreased significantly in the three groups ; however , apo AI after oral glucose ingestion showed no change in the three groups . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
As there is a strong correlation between control and the degree of lipid changes , even with normal levels of cholesterol and triglycerides , measurements of Apo AI , Apo B 100 and Apo CIII seem to be good and reliable indicators of glycemic control in diabetic children , and a factor with high predictive value for the evaluation of cardiovascular risk in adult patients . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Triglyceride ( TG ) , total cholesterol ( TC ) and high density lipoprotein cholesterol ( HDL C ) were measured with enzyme methods , apolipoprotein A 1 , apolipoprotein B 100 ( Apo B 100 ) and lipoprotein ( alpha ) [ Lp ( alpha ) ] were measured with immune multifocal method , and low density lipoprotein cholesterol ( LDL C ) was calculated according to Friedewald formula . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein AI or B 100 containing particles ( Apo AI or Apo B 100 ) were isolated by immunoaffinity columns prepared with monoclonal antibodies . ^^^ Both the EC / FC ratio levels in Apo AI and in Apo B 100 in group C were significantly higher than those in group A or B . ^^^ The insulin resistance index showed significant positive correlation with the EC / FC ratio levels in Apo AI and in Apo B 100 , and showed significant negative correlation with the CH levels in Apo AI / apolipoprotein AI ratio and the CH levels in Apo B100 / apolipoprotein B 100 ratio levels in group C . ^^^ Apolipoprotein AI or B 100 containing particles ( Apo AI or Apo B 100 ) were isolated by immunoaffinity columns prepared with monoclonal antibodies . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Among plasma TG , TC , HDL C , apo AI , apo AII , apo B 100 , apo CII , Apo CIII and apoE , only HDL C and apo AI were significantly different among the three genotypes +1075A / A , +1075A / C and +1075C / C in men ( P=0 . 029 and 0 . 032 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The plasma glucose levels were positively correlated with apo B 100 , C 3 and E levels in groups S 1 , S 2 and S 3 , P < 0 . 001 ) , with apo C 2 in groups S 1 and S 2 ( P < 0 . 001 , P < 0 . 01 ) ; and negatively correlate to apoA 1 only in group S 2 ( r = 0 . 1182 , P < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Butyrate stimulates the secretion of apolipoprotein A 1 and apolipoprotein B 100 in Hep G 2 cells by different mechanisms . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
As compared with male nonsmokers , male smokers showed a higher mean level of low density lipoprotein ( LDL ) cholesterol ( 112 versus 100 mg / dL , p less than 0 . 05 ) , a higher LDL cholesterol to HDL cholesterol ratio ( 2 . 27 versus 1 . 94 , p less than 0 . 001 ) , a higher mean level of apolipoprotein B 100 ( 59 versus 53 mg / dL , p less than 0 . 05 ) , and a higher apolipoprotein B 100 to apolipoprotein A 1 ratio ( 0 . 45 versus 0 . 40 , p less than 0 . 01 ) . ^^^ Female smokers tended to show the same results , although significant differences were only found for LDL cholesterol to HDL cholesterol ratio and apolipoprotein B 100 to apolipoprotein A 1 ratio ( 1 . 8 versus 1 . 59 and 0 . 41 versus 0 . 38 respectively , both p less than 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Decreased concentrations of apolipoprotein A 1 in high density ( 1 . 063 to 1 . 210 g / ml ) lipoprotein were also observed , although not as distinctly as with apolipoprotein B 100 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
High density lipoprotein and low density lipoprotein cholesterol as well as apolipoprotein A 1 decreased to the same extent ( 8 to 11 % ; p < . 05 ) during the oat bran period , whereas a pronounced reduction of 25 . 8 % was seen for apolipoprotein B 100 ( p < . 01 ) , which is a major component of low density lipoprotein . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After reestablishment of a steady state in body weight at the lower level , measurements were made of plasma lipid , lipoprotein , and apolipoprotein levels and the kinetics of low density lipoprotein ( LDL ) apolipoprotein B 100 ( apo B ) and apolipoprotein A 1 ( apo A 1 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum low density lipoprotein cholesterol decreased 8 . 5 % ( P less than 0 . 05 ) , apolipoprotein B 100 decreased 8 . 7 % ( P less than 0 . 05 ) , and the ratio of apolipoprotein B 100 to apolipoprotein A 1 decreased 9 . 5 % ( P less than 0 . 05 ) during the bakery diet . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein A 1 and HDL subfraction 2 levels were significantly higher and apolipoprotein B 100 levels were significantly lower in the surgical group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Neither FO amount resulted in significant changes in total or HDL cholesterol , apolipoprotein A 1 , or apolipoprotein B 100 . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein B 100 was significantly lower , and apolipoprotein A 1 and HDL 2 were significantly higher in the surgery group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein AI activates the lecithin cholesterol acyltransferase , apolipoprotein CII and CIII regulate the lipoprotein lipase , and apolipoprotein B 100 , B 48 , and E control the cholesterol uptake into hepatic and extrahepatic cells . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : We assessed 240 consecutive patients undergoing coronary balloon angioplasty with measurements of Lp ( a ) , total cholesterol , triglycerides , HDL cholesterol , LDL cholesterol , apolipoprotein A 1 , and apolipoprotein B 100 concentrations from fresh specimens . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Children in the highest tertile of total fat consumption , compared with children in the lowest tertile , had significantly higher mean serum levels of total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein A 1 ( Apo A ) and apolipoprotein B 100 ( Apo B ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Metabolic parameters were total cholesterol , triglycerides , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) , very low density lipoprotein ( VLDL ) , sex hormone binding globulin , apolipoprotein A 1 , apolipoprotein B 100 , and total and direct bilirubin . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The evaluation included a blood analysis of serum triglycerides ( TG ) , total cholesterol ( CT ) , low density lipoprotein cholesterol ( LDL ) , high density lipoprotein cholesterol ( HDL ) , apolipoprotein A 1 ( ApoA ) , apolipoprotein B 100 ( Apo B ) , and the Apo A / Apo B and LDL / HDL ratios . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We used a panel of specific antibodies to different lipoproteins and their apolipoprotein constituents , namely LDL , formaldehyde fixed LDL , apolipoprotein B 100 , HDL , and formaldehyde fixed apolipoprotein A 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES Concentrations of total and low density lipoprotein , Lp ( a ) lipoprotein , high density lipoprotein , apolipoprotein B 100 , and apolipoprotein A 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The following polymorphic variants were analyzed : RFLP Sacl of the apolipoprotein AI CIII AIV cluster , RFLP Xbal of the apolipoprotein B 100 region and the RFLP Taql of the apolipoprotein E CI CII cluster . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There was negative correlation with apolipoprotein A 1 and value of apolipoprotein A1 / apolipoprotein B 100 , but positive correlation with systolic blood pressure by linear regression analysis for urinary albumin excretion . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Immigrants recruited through Refugee Screening had anthropometric data recorded and blood collected to measure total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL ) , and triglyceride ( TG ) by Reflotron ; apolipoprotein A 1 ( apo A 1 ) and apolipoprotein B 100 ( apo B ) by immunoturbidimetric analyses ( Turbitimer ) ; and lipoprotein ( a ) ( LP ( a ) ) by ELISA . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Our results revealed a statistically significant reduction in total cholesterol , triglycerides and LDL cholesterol concentrations as well as Apolipoprotein B100 / Apolipoprotein A 1 , total cholesterol / HDL cholesterol and LDL cholesterol / HDL cholesterol ratios , and a significant increase in HDL cholesterol , Apolipoprotein A 1 , Apolipoprotein B 100 and Lipoprotein ( a ) values . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The serum total cholesterol ( TC ) , triglyceride ( TG ) , very low density lipoprotein of cholesterol ( VLDL ) , apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B 100 ( apoB 100 ) were all changed ( P < 0 . 05 ) . apoA1 / apoB100 ratio increased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
PRACTICE DESCRIPTION : A total of 240 serum / urine samples from 50 healthy volunteers and from 190 patients with different degrees of chronic renal failure , which fall into four groups according to their glomerular filtration rates , were measured for serum levels of triglyceride , lipoprotein ( a ) , lipoprotein ( a ) cholesterol , total cholesterol , apolipoprotein A 1 , apolipoprotein B 100 , low density lipoprotein cholesterol , high density lipoprotein cholesterol , and for urine albumin concentrations ; the levels of these criteria were compared between the control group and diseased groups ; the mean concentrations of different lipid variables were paired and subjected to linear regression analysis . ^^^ MAIN OUTCOME MEASUREMENTS : Glomerular filtration rates were estimated by the iohexol clearance method , in which plasma content of iohexol was measured with high performance liquid chromatography ; concentrations of triglyceride , lipoprotein ( a ) , lipoprotein ( a ) cholesterol , total cholesterol , apolipoprotein A 1 , apolipoprotein B 100 , low density lipoprotein cholesterol , high density lipoprotein cholesterol , and albumin were assayed according to standard protocols . ^^^ RESULTS : Serum levels of triglyceride , lipoprotein ( a ) , lipoprotein ( a ) cholesterol , total cholesterol , apolipoprotein A 1 , apolipoprotein B 100 , low density lipoprotein cholesterol , and urine albumin contents were significantly higher , whereas those of high density lipoprotein cholesterol were lower , in diseased groups than that of the control ( p < 0 . 05 , p < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein B 100 secretion was 30 % 36 % decreased when using 10 1000 nmol / l and no change was observed for the secretion of apolipoprotein A 1 and albumin which were measured as control proteins . ^^^ Concentrations of apolipoprotein B 100 and apolipoprotein A 1 mRNA were not changed after incubation with insulin . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein B 100 was reduced by 18 . 3 % ( P = 0 . 008 ) , and apolipoprotein AI by 12 . 3 % ( NS ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A significant decrease in apolipoprotein B 100 concentrations was observed ( P = 0 . 037 ) , whereas high density lipoprotein cholesterol , triglycerides , apolipoprotein AI , and lipoprotein ( a ) levels remained unchanged . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The plasma concentration and hepatic synthesis rates of albumin , transthyretin , very low density lipoprotein apolipoprotein B 100 ( VLDL apoB 100 ) , high density lipoprotein apolipoprotein A 1 , fibrinogen , alpha 1 antitrypsin , and haptoglobin were measured in six normal adults before and after consuming a protein intake of 0 . 6 g . kg body wt ( 1 ) . day ( 1 ) for 7 days . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Lipoprotein ( a ) , total cholesterol , high density lipoprotein cholesterol , low density lipoprotein cholesterol , triglycerides , apolipoprotein A 1 and apolipoprotein B 100 were determined in sera from 129 consecutive fasting Greek patients with inflammatory bowel disease ( 66 with ulcerative colitis and 63 with Crohn ' s disease ) and from 66 matched healthy controls . ^^^ Mean apolipoprotein A 1 and apolipoprotein B 100 levels were significantly lower in Crohn ' s disease patients than in the controls . ^^^ In ulcerative colitis patients the mean levels of lipoprotein ( a ) and apolipoprotein A 1 were not significantly different to the controls , but the levels of apolipoprotein B 100 were significantly lower . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Obtained data strongly suggest that decreases in serum concentrations of apolipoprotein B 100 , apolipoprotein A 1 and apolipoprotein C 3 , a reduction in activity of lecithin : cholesterol acyltransferase and induction of haptoglobin and serum amyloid A are intimately related to the development of fatty liver and fatty liver related diseases . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A significant correlation between plasma reducing activity with apolipoprotein B 100 was observed ( r = 0 . 290 ) , but not with apolipoprotein A 1 ( r = 0 . 118 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : The serum concentrations of dehydroepiandrosterone sulphate ( DHEA S ) , ASD , total and free testosterone , estradiol , total cholesterol , LDL cholesterol ( LDL C ) , HDL cholesterol ( HDL C ) , triglycerides , apolipoprotein AI ( ApoAI ) and apolipoprotein B 100 ( ApoB 100 ) were measured in a sample of 88 healthy men . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were significant between group differences ( responders nonresponders ) in the mean 12 month changes in HDL cholesterol levels ( 8 . 0 mg / dL ; 95 % confidence interval [ CI ] : 3 to 13 mg / dL ; P = 0 . 002 ) , apolipoprotein A 1 levels ( 21 mg / dL ; 95 % CI : 8 to 33 mg / dL ; P = 0 . 003 ) , and the LDL cholesterol to HDL cholesterol ratio ( 0 . 6 ; 95 % CI : 0 . 1 to 1 . 0 ; P = 0 . 03 ) , but not in LDL cholesterol , apolipoprotein B 100 , or lipoprotein ( a ) levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The metabolic syndrome is characterized by insulin resistance and abnormal apolipoprotein AI ( apoAI ) and apolipoprotein B 100 ( apoB ) metabolism that may collectively accelerate atherosclerosis . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Study on plasma lipids , apolipoprotein A 1 , apolipoprotein B 100 in simple obese children ] . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The mean values of total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , TC / HDL C ratio , lipoprotein ( a ) ( Lp [ a ] ) , apolipoprotein A 1 ( apo AI ) apolipoprotein B 100 ( apo B ) and apo B / apo A ratio were higher and triglycerides ( TG ) were lower , compared with those with normal levels of thyrotropin . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Low density lipoprotein ( p < 0 . 05 ) and apolipoprotein B 100 ( p < 0 . 01 ) decreased , while HDL constituent apolipoprotein A 1 ( p < 0 . 05 ) increased after micronised fenofibrate treatment . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However , only rosuvastatin treatment significantly ( p < 0 . 05 to < 0 . 001 ) reduced fasting low density lipoprotein cholesterol , apolipoprotein B 100 , apolipoprotein C 3 , apolipoprotein C 3 : B particles , the apolipoprotein B 100 : apolipoprotein A 1 ratio , and increased apolipoprotein A 1 ( p < 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum was analysed for lipid and lipoprotein profile ( total and high density lipoprotein cholesterol , triglycerides , apolipoprotein B 100 , apolipoprotein A 1 , lipoprotein ( a ) ) , and sialic acid , fibrinogen , homocysteine , and C reactive protein ( CRP ) concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The content of lipid peroxide ( LPO ) increased significantly after 2 weeks supplementation . ( 4 ) Total cholesterol ( TC ) , triglyceride ( TG ) , Low density lipoprotein cholesterol ( LDL C ) and apolipoprotein B 100 ( ApoB 100 ) increased significantly , high density lipoprotein cholesterol ( HLD C ) and apolipoprotein A 1 ( ApoA 1 ) decreased after supplementation . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Serum concentrations of total cholesterol , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) , triglycerides , apolipoprotein A 1 , apolipoprotein B 100 , and lipoprotein ( a ) were compared between danazol treated patients with HAE and 2 control groups ( ie , patients who did not receive long term danazol prophylaxis and untreated healthy subjects ) . ^^^ RESULTS : Serum concentrations of HDL ( P = . 0002 and P < . 0001 ) and apolipoprotein A 1 ( P = . 0015 and P < . 0001 ) were significantly lower , whereas LDL ( P = . 0129 and P = . 0127 ) and apolipoprotein B 100 ( P = . 0456 and P = . 0013 ) were higher in the danazol treated patients compared with the 2 control groups , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
OBJECTIVE : To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause , apolipoprotein B 100 ( apoB 100 ) and apoA 1 kinetic behavior was assessed . ^^^ TRL , IDL , and LDL apolipoprotein B 100 and HDL apolipoprotein A 1 kinetics as a function of age and menopausal status . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A group of 315 children ( group A ) aged more than 2 years old with a positive family history were evaluated for serum concentrations of total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol ( HDL C ) , triglycerides ( TG ) , apolipoprotein B 100 ( ApoB 100 ) , apolipoprotein A 1 ( Apo A 1 ) , and lipoprotein ( a ) ( Lp [ a ] ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
C reactive protein , homocysteine , amyloid A , lipoprotein ( a ) , fibrinogen , apolipoprotein A 1 , and apolipoprotein B 100 serum levels , and microalbuminuria were measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RECENT FINDINGS : The dysregulation of lipoprotein metabolism may be caused by a combination of overproduction of VLDL apolipoprotein B 100 , decreased catabolism of apolipoprotein B containing particles , and increased catabolism of HDL apolipoprotein A 1 particles . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Results from recent epidemiological studies and statin trials suggest that apolipoprotein B 100 ( apoB ) , with or without apoA 1 , is superior to LDL cholesterol in predicting coronary events . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RGJ supplementation also caused a significant decrease in LDL cholesterol and apolipoprotein B 100 concentrations , while increasing the concentrations of HDL cholesterol and apolipoprotein A 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 and ApoB were also examined because of their importance in HDL and VLDL structure , respectively . ^^^ ApoA 1 and ApoB were measured by radioimmunoassay . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apolipoprotein B ( apoB ) and apolipoprotein A 1 ( apoA 1 ) in the perfusate were measured by solid phase radioimmunoassay . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Monospecific antisera were produced to two chylomicron apoproteins ( apoB , apoA 1 ) and utilized for indirect immunofluorescent localization of these apoproteins within rat intestinal epithelium during normal and impaired lipid absorption . ^^^ During an experimental condition of impaired protein synthesis there was a marked reduction in the mucosal content of both apoA 1 and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoprotein A 1 ( apoA 1 ) and apolipoprotein B ( apoB ) were studied in a patient with type IIb hyperlipoproteinaemia . ^^^ These changes were accompanied by a decrease in the plasma concentrations of apoA 1 and apoB which resulted from a reduction of apoprotein synthetic rate . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Normal plasma chylomicrons contained apoB , apoE and the C peptides but not apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To ascertain that the liver is a source of `` diet induced VLDL , ' ' we fed rats CHO and control diets and we examined plasma levels of lipids chemically and apoproteins A 1 ( ApoA 1 ) and B ( ApoB ) by specific radioimmunoassay ( RIA ) . ^^^ In the CHO fed rats , plasma TG increased , cholesterol and ApoA 1 remained unchanged , and ApoB fell . ^^^ The perfused livers of the CHO fed rat secreted more TG , but absolute secretory rates for cholesterol , ApoB , and ApoA 1 were unchanged . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In addition , tissue levels of ApoA 1 and ApoB were measured during fat absorption by radioimmunoassay . ^^^ Antisera were produced using ApoA 1 isolated from rat plasma high density lipoprotein , and ApoB and ARP from plasma VLDL by column chromatography . ^^^ The distribution and time course of ApoB staining was nearly identical with that of ApoA 1 . ^^^ Thus , ApoA 1 and ApoB appeared to participate in the intracellular assemply of lipoproteins in gut , whereas ARP did not , although ARP was found within mucosal cells . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Of the 3H incorporated into individual apolipoproteins , separated by polyacrylamide gel electrophoresis , 25 % was recovered in apolipoprotein B ( apoB ) , 50 % in apoA 1 , 21 % in apoA 4 , and 4 % in C apolipoproteins , nearly all in apoC 2 and apoC 3 0 . ^^^ Labeled apoB was found in chylomicrons and very low density lipoproteins and labeled apoA 1 and apoA 4 in all lipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 from HDL , apoB from LDL , and apoC 3 from VLDL , as well as neutral lipid , were all localized to connective tissue and extracellular lipid pools in atherosclerotic lesions , and only to areas of intimal thickening in grossly `` uninvolved ' ' arteries . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 from high density lipoproteins , apoB from low density lipoproteins , and apoC 3 from very low density lipoproteins were localized also as markers for their respective lipoproteins , since the latter cross react immunologically . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Logistic regression analysis revealed the strongest independent predictors of CHD in Type 1 diabetes were serum triglycerides , systolic blood pressure , age , serum LDL cholesterol , and the daily insulin dosage , whereas in the non diabetic control group HDL 2 cholesterol , Lp ( a ) , ApoA 1 and ApoB , total serum cholesterol and body mass index were additional predictors . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The serum levels of total and LDL cholesterol , TG , ApoAI , ApoB and ApoCII in patients before treatment were all higher than those of the control group . ^^^ The mean values of total cholesterol decreased from 6 . 7 mmol / L to 4 . 1 mmol / L , TG decreased from 2 . 5 mmol / L to 1 . 0 mmol / L , LDI ch from 3 . 9 mmol / L to 2 . 4 mmol / L , ApoAI from 1 . 9 g / L , to 1 . 3g / L , ApoB from 1 . 2 g / L to 0 . 7 g / L and ApoCII decreased from 6 . 9 mg / dl to 3 . 9 mg / dl . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The effects of the long term administration of the dietary fats coconut oil and corn oil at 31 % of calories with or without 0 . 1 % ( wt / wt ) dietary cholesterol on plasma lipoproteins , apolipoproteins ( apo ) , hepatic lipid content , and hepatic apoA 1 , apoB , apoE , and low density lipoprotein ( LDL ) receptor mRNA abundance were examined in 27 cebus monkeys . ^^^ In animals fed coconut oil without cholesterol , significantly higher ( P less than 0 . 05 ) plasma total cholesterol ( 145 % ) , very low density lipoprotein ( VLDL ) + LDL ( 201 % ) and high density lipoprotein ( HDL ) ( 123 % ) cholesterol , apoA 1 ( 103 % ) , apoB ( 61 % ) , and liver cholesteryl ester ( 263 % ) and triglyceride ( 325 % ) levels were noted , with no significant differences in mRNA levels relative to the corn oil only group . ^^^ In animals fed coconut oil plus cholesterol , all plasma parameters were significantly higher ( P less than 0 . 05 ) , as were hepatic triglyceride ( 563 % ) and liver apoA 1 ( 123 % ) and apoB ( 87 % ) mRNA levels relative to the corn oil only group , while hepatic LDL receptor mRNA ( 29 % ) levels were significantly lower ( P less than 0 . 05 ) . ^^^ Correlation coefficient analyses performed on pooled data demonstrated that liver triglyceride content was positively associated ( P less than 0 . 05 ) with liver apoA 1 and apoB mRNA levels and negatively associated ( P less than 0 . 01 ) with hepatic LDL receptor mRNA levels . ^^^ Interestingly , while a significant correlation ( P less than 0 . 01 ) was noted between hepatic apoA 1 mRNA abundance and plasma apoA 1 levels , no such relationship was observed between liver apoB mRNA and plasma apoB levels , suggesting that the hepatic mRNA of apoA 1 , but not that of apoB , is a major determinant of the circulating levels of the respective apolipoprotein . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Significant differences were observed between the two dialysis procedures , CAPD patients showed elevated plasma cholesterol , apo AI and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Administration of conjugated equine estrogen to 31 postmenopausal women for 3 months produced 14 . 6 % and 9 . 4 % decreases in low density lipoprotein cholesterol ( LDL C ) and apolipoprotein B ( apoB ) , and 11 . 5 % , 12 . 7 % , and 9 . 6 % increases in high density lipoprotein cholesterol ( HDL C ) , apoA 1 and apoA 2 , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 , apoA 4 , and apoB mRNA levels in hepatic and in intestinal tissue were undistinguishable between the uremic and surgical sham rats . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The findings reported here , that apo other than apoA 1 and apoB exhibit saturable binding of T 4 , suggest that thyroid hormone lipoprotein interactions may have even wider physiological implications than previously appreciated . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The increase in apoA 1 and apoB with gestation was parallel to the respective changes in HDL and LDL cholesterol and , again , no difference was observed between the three groups . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have attempted to review new information concerning the regulation of the secretion of three major apolipoproteins that are synthesized in the liver : apoB , apoA 1 , and apoE . ^^^ The regulation of the secretion of apoA 1 by liver is very different from that of apoB . ^^^ Although apoA 1 is also synthesized on attached ribosomes and becomes contranslationally or post translationally associated with the RER membrane , it is transported to the Golgi much more rapidly than apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The patients also had reduced levels of ApoA 1 and ApoA 2 , increased levels of ApoC 2 and ApoC 3 , while increases in levels of ApoB and ApoE were statistically significant in patients with GFR < 20 ml / min . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum trypsin like activity in chronic alcoholized men : possible relationship with lipids , apoA 1 and apoB lipoproteins . ^^^ One hundred and forty six male chronic alcohol users were tested for serum trypsin like activity ( STA ) , total cholesterol ( TC ) , LDL cholesterol ( LDL C ) , HDL / cholesterol ( HDL C ) , triglycerides ( TG ) , apoA 1 and apoB lipoproteins . ^^^ STA was positively correlated to LDL C , TG and apoB rates and the CT / HDL C index and negatively correlated to HDL C and apoA 1 rates and the apoA 1 / apoB index . ^^^ Eighty four patients with high STA ( group B ) compared to 62 patients with normal STA ( group A ) showed significantly higher LDL C , TG , apoB rates and TC / HDL C index contrasting with significantly lower HDL C and apoA 1 rates and the apoA 1 / apoB index . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were no significant variations of the lipid fractions or of the ApoA 1 and ApoB during the menstrual cycle in each group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
They yield supernatants which contained almost all of the apoA 1 and apoA 2 lipoproteins but no lipoprotein apoB . ^^^ Correspondingly , two common precipitation methods for the determination of LDL cholesterol in human serum , buffered heparin , and polyvinyl sulphate procedures , produced sediments , which contained the major proportion of the apoB and only small amounts of apoA 1 and apoA 2 . ^^^ According to the present results it was found that highly significant correlations existed between chol / chol HDL or chol LDL / chol HDL and apoB / apoA 1 ratios ( p < 0 . 001 ) . ^^^ It is quite evident that apoB and apoA 1 values could be used to replace chol LDL and chol HDL values when the risk for the cardiovascular diseases is to be assessed . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After intake of 400 ml / day of whole milk for 29 days , LDL , HDL and total cholesterol concentrations were even more increased and the VLDL phospholipid concentration was decreased , with significant increases in apoA 1 , apoA 2 and apoB concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total and HDL cholesterol , apoA 1 , apoB , and Lp ( a ) decreased by as much as 7 12 % in the supine position and returned to baseline values 20 40 min after the standing position was resumed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Age , cigarette smoking , hypertension , obesity , diabetes , positive family history of premature coronary artery disease ( CAD ) , and plasma levels of total cholesterol , triglyceride , lipoproteins ( i . e . , very low , intermediate , low , and high density [ HDL ] lipoproteins and their subfractions [ HDL 2 and HDL 3 ] , and lipoprotein [ a ] ) and apolipoproteins ( apoA 1 , apoA 2 and apoB , respectively ) were examined using univariate analyses and multivariate logistic regression . ^^^ It is concluded that the `` nontraditional ' ' risk factors ( plasma apoA 1 and apoB levels ) are better predictors of premature CAD than are plasma lipoproteins and that smoking is the strongest of the traditional nonlipid risk factors . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The following parameters were measured : total cholesterol ( Chol ) , triglycerides ( TG ) , HDL cholesterol ( HDL C ) , LDL cholesterol ( LDL C ) , apoprotein A 1 ( apoA 1 ) , apoprotein B ( apoB ) , lipoprotein ( a ) or Lp ( a ) , fibrinogen , insulinemia and plasminogen activator inhibitor activity ( PAI ) . ^^^ The levels of TG , HDL C , apoA 1 and the ApoA 1 / APoB ratio were significantly different between groups 1 and 2 , on the one hand , and groups 1 and 3 , on the other hand . ^^^ In this study , TG , HDL chol , apoA 1 and the apoB ratio were better predictors of cardiovascular risk than Chol , LDL C or apoB . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Consistently among control groups , rare homozygotes had lower mean levels of ApoB ( P less than 0 . 02 ) , triglycerides ( P less than 0 . 02 ) , and lipoprotein particles containing ApoE and ApoB ( LpE : B ; P less than 0 . 001 ) and a higher mean level of lipoprotein particles containing ApoAI and not ApoAII ( LpAI ; P less than 0 . 02 ) than heterozygotes and frequent homozygotes combined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Because ApoA 2 is an integral protein constituent of three distinct lipoprotein families ( LP A 1 : A 2 , LP A 2 : B : C : D : E and LP A 2 ) , LP A 2 particles were isolated from whole plasma by sequential immunoaffinity chromatography on immunosorbers with antisera to ApoA 2 , ApoB and ApoA 1 , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Biosynthesis of lipoprotein : location of nascent apoAI and apoB in the rough endoplasmic reticulum of chicken hepatocytes . ^^^ In this study , we have used three different methodologies to determine the locations of apoAI and apoB in the RER and compared them to that of albumin . ^^^ Immunoelectron microscopic examination of the RER cell fractions showed that both apoAI and apoB were associated only with the RER membrane whereas albumin was located both within the lumen and on the limiting membrane of the vesicles . ^^^ To examine the possibility of membrane integration of nascent apoAI and apoB in the RER , we administered L [ 3H ] leucine to young chickens for 10 min , isolated RER , treated this cell fraction with buffers of varying pH , and measured the release of radioactive albumin , apoAI , and apoB . ^^^ The majority of nascent apoAI ( 64 % ) , nascent apoB ( 100 % ) , and nascent albumin ( 97 % ) was released from RER vesicles at pH 11 . 2 , suggesting that , like albumin , apolipoproteins are not integrated within the membrane . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In order to establish the reference ranges of lipids and apolipoproteins apoA 1 and apoB in serum for different periods of pregnancy we examined 719 healthy pregnant women . 172 of them were in the first trimester , 227 in the second and 320 in the third trimester . ^^^ All lipids and apolipoproteins apoA 1 and apoB were significantly elevated during the second and the third trimesters . ^^^ The 95th percentiles of the distributions in the second and the third trimesters are : total triglyceride : 2 . 87 and 4 . 68 mmol / l ; total cholesterol : 8 . 24 and 9 . 83 mmol / l ; LDL cholesterol : 5 . 61 and 6 . 48 mmol / l ; apoA 1 : 2 . 48 and 2 . 61 g / l ; apoB : 1 . 47 and 1 . 92 g / l . ^^^ The ratios of total cholesterol to HDL cholesterol , of LDL cholesterol to HDL cholesterol and apoB to apoA 1 were decreased in the first trimester , without change in the second , and increased in the third trimester . ^^^ The most prominent change was a 2 . 7 fold triglyceride increase in the third trimester ; in the same trimester the mean level apoB increased by 56 % , total cholesterol by 43 % , low density lipoprotein ( LDL ) cholesterol by 36 % and apolipoprotein A 1 by 32 % . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In boys univariate analysis revealed an association of triglycerides , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein B ( ApoB ) , the ratio ApoAI / ApoB , cholesterol / HDL C , glucose and insulin to WHR . ^^^ In girls lipid parameters ( triglycerides , LDL C , HDL C , HDL 2 , ApoAI , ApoB ) and atherogenic ratios correlated with measures of obesity and WHR . ^^^ Multivariate analysis in girls revealed a first step dependency of ApoAI , the ratio cholesterol / ApoAI , insulin , SBP and DBP on WHR , triglycerides , HDL C , LDL C and the ratio ApoAI / ApoB , a first step dependency on percent body fat mass . ^^^ In boys triglycerides , ApoB and the ratio ApoAI / ApoB were related to WHR for insulin , SBP and DBP , but a positive association with the WHR was found , explaining 33 , 21 . 8 , and 22 . 6 % of the variance . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Human liver contained apoA 1 , apoA 2 as well as apolipoprotein B ( apoB ) mRNA . ^^^ In contrast , human adult small intestine total and polyA+ RNA had little or no apoA 2 despite the presence of apoA 1 and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To detect the associations between the CETP polymorphisms and serum lipid and apoprotein levels , we determined the serum concentrations of total cholesterol , triglycerides , high density lipoprotein ( HDL ) cholesterol , apoA 1 , apoA 2 and apoB in the subjects studied and correlated them to the 3 RFLPs . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cellular apoB and media and cellular apoA 1 concentrations were not affected by oleic acid . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The paper discusses the results from a study into apolipoproteins B ( apo B ) and AI ( apo AI ) and apoB / apo AI ratios in the blood of 188 healthy donors and 122 male patients with coronary atherosclerosis . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Goserelin induced a significant elevation in HDL C ( by 31 . 4 % ) , in HDL 2 C ( 24 . 6 % ) and in HDL 3 C ( 45 . 7 % ) but no significant change in LDL C or in ApoA 1 and ApoB . ^^^ The lipoprotein changes during goserelin had a favourable effect on the atherogenic index ( cholesterol / HDL C ) and ApoA 1 / ApoB ratio whereas those of danazol had opposite effects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In comparison with control subjects , diabetics showed marked increases in the following parameters : total cholesterol ( TC ) , low density lipoprotein ( LDL ) cholesterol , total triglycerides ( TG ) , very low density lipoprotein ( VLDL ) triglycerides , phospholipids , apoB , LDL apoB , glucose and glycosylated hemoglobin ( HbA1c ) as well as the ratios of total cholesterol / high density lipoprotein ( HDL ) cholesterol , LDL cholesterol / HDL cholesterol , LDL cholesterol / high density lipoprotein ( HDL ) cholesterol , LDL cholesterol / HDL cholesterol , LDL cholesterol / high density lipoprotein 2 ( HDL 2 ) cholesterol and apoB / apoAI . ^^^ Despite insulin therapy in both the diabetic groups studied , abnormalities in lipids , apoB and apoAI still persisted . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Overnight fasting of euthyroid rats did not alter hepatic apoA 1 secretion or plasma apoA 1 levels , although under fasting conditions we had reported that hepatic output of apoB and E of VLDL is depressed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The parenchymal and nonparenchymal cells were separated by standard methods , and the CETP , apoA 1 , apoB , and apoE mRNA content of the preparation determined at each step in the purification process . ^^^ ApoA 1 and apoB are produced only in the parenchymal cells ; apoE is produced by both cell types . ^^^ The mRNA measurements showed that the CETP mRNA : apoA 1 mRNA and the CETP mRNA : apoB mRNA ratios were more than 2500 fold greater in the nonparenchymal cell preparation than in the starting material , and that the purified parenchymal cell fraction was virtually devoid of CETP mRNA . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We report expression of LDL receptor , apolipoprotein B ( apoB ) , apolipoprotein A 1 ( apoA 1 ) and apolipoprotein A 4 ( apoAIV ) mRNA in various mouse organs . ^^^ For preparing specific probes , we cloned cDNA fragments of rat LDL receptor , apoB and apoA 1 and mouse apoA 4 into the polylinker region of pGEM3Zf ( + ) and used the recombinant vectors for preparing 32P labeled cRNA probes as well as RNA standards using the T 7 and SP 6 promoters flanking the polylinker regions . ^^^ ApoB , apoA 1 and apoA 4 genes in mice are expressed in the liver and intestine and LDL receptor gene is expressed mainly in liver , intestine and adrenals . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Incubation of IDL or LDL subfractions with palmitic acid and either high density lipoproteins ( HDL ) , apoHDL , or purified apoA 1 gives rise to apoA 1 , apoB containing complexes that can dissociate into two particles , an apoB containing lipoprotein with particle diameter 10 30 A smaller than the starting material , and a still smaller species ( apparent peak particle diameter 140 190 A ) containing lipid and apoA 1 but no apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
DiI LDL binding was saturable and specific , with strong inhibition by unlabeled LDL and apoB but not by apoA 1 , bovine serum albumin , or IgG , and only weak inhibition by high density lipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Gemfibrozil lowered plasma triglycerides , VLDL cholesterol and apolipoprotein B ( apoB ) , increased HDL cholesterol and apoAI levels in both groups , and induced a very substantial reduction in LDL cholesterol in type IIa patients only . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
CRF : HD patients had slightly higher ApoA 1 and ApoA 2 and lower ApoB levels compared to CRF : 2 patients . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Peak VO 2 ( 10 = 2 . 13 l . min 1 ) was assessed by a graded arm crank test to maximum , percent body fat ( 10 = 28 . 7 % ) by densitometry , and lipid profile by measures of serum triglycerides , total cholesterol ( TC ) , high and low density lipoprotein cholesterol ( HDL C and LDL C , respectively ) , apolipoproteins ( apoA 1 , apoB ) , and various ratios of lipids , lipoproteins , and apolipoproteins . ^^^ Significant inverse relationships emerged between peak VO 2 and TC / HDL C ( r = 0 . 86 ; P less than 0 . 01 ) , apoB / apoA 1 ( r = 0 . 75 ; P less than 0 . 05 ) , triglycerides ( r = 0 . 73 ; P less than 0 . 05 ) , and LDL C / HDL C ( r = 0 . 72 ; P less than 0 . 05 ) . ^^^ Direct correlations ( P less than 0 . 05 ) were demonstrated between peak VO 2 and apoA 1 / apoB ( r = 0 . 71 ) and HDL C / apoA 1 ( r = 0 . 64 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In both groups , measurements were obtained for total cholesterol level , triglyceride level , cholesterol contents in apoB and nonapoB containing particles ( LpB , LpnonB ) , total apoB and apolipoprotein AI ( apoAI levels ) , lipoprotein particles recognized by monoclonal antibodies anti apoB ( LpBL 3 , LpBL 5 , LpBL 7 ) and anti apoAI ( LpAI 2GII ) . ^^^ This was confirmed by an increase in total apoB and a decrease in total apoAI . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fractionation of an d = 1 . 050 1 . 090 fraction by concanavalin A chromatography ( CONA ) yielded an unbound apoE rich fraction that contained apoE , apoAI and apoC but no apoB , and a bound LDL like fraction that contained mostly apoB 100 , as determined by SDS PAGE and by solid phase immunoassays , containing monoclonal antibodies directed against apoB , apoE and apoAI . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Binding experiments using synthetic apoB mRNAs indicate that the 40 kDa protein would also bind to apoB 48 mRNA but not apoA 1 , apoA 4 , apoC 2 or apoE mRNA . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma triglycerides and low density lipoprotein cholesterol ( LDL C ) levels were significantly higher , whereas high density lipoprotein cholesterol ( HDL C ) and apoprotein A 1 ( ApoA 1 ) levels , as well as the HDL C / LDL C and ApoA1 / ApoB ratios , were significantly lower in moderately to severely obese women ( Body Mass Index greater than 30 , n = 26 ) than in non obese post menopausal controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The following increases in hepatic RNA levels , relative to controls , were measured : poly A+ ( 1 . 2 ) , ribosomal ( 1 . 2 ) , mRNA levels for transferrin ( 1 . 8 ) , albumin ( 3 . 8 ) apolipoprotein ( apo ) E ( 2 . 3 ) , apoB ( 2 . 5 ) , apoA 2 ( 1 . 9 ) and apoA 1 ( 6 . 1 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoB in plasma decreased by 21 % and apoA 1 by 17 % ; however , apoE and ApoA 2 did not change . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ratio between apoB and apoA 1 lipoproteins increased by 18 % in shift workers compared with 5 % in day workers . ^^^ The change in the ratio between apoB and apoA 1 lipoproteins showed a significant inverse correlation with the change in intake of dietary fibres . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The triglyceride rich VLDL contained mainly apoE ( 75 % ) and apoB ( 23 % ) , while the protein moiety of LDL was composed of apoB ( 59 % ) , apoE ( 20 % ) , apoA 1 ( 15 % ) , and apoC 3 ( 6 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
On the cholesterol rich diet the high responders , when compared to the low responders , had several fold increased plasma cholesterol and apoB concentrations and significantly lower HDL apoA 1 and cholesterol concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The levels of plasminogen activator inhibitor ( PAI ) , protein C ( pC ) , total cholesterol ( TC ) , high and low density lipoprotein cholesterols ( HDLC and LDLC ) , apolipoproteins A 1 ( apoA 1 ) and B ( apoB ) were measured in 45 patients with coronary heart disease angiographically documented and 10 healthy subjects without coronary heart disease and coronary atherosclerosis as evidenced by coronary angiography and provocative tests . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
PSMF for 4 weeks caused a 20 % decrease in plasma cholesterol , LDL C and apoB levels but also a decrease of HDL C , apoA 1 and apoA 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
No differences were found in serum levels of total , low density lipoprotein ( LDL ) , and high density lipoprotein ( HDL ) cholesterol or apoA 1 , and apoB lipoproteins or triglycerides . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The molecular biology of human apoA 1 , apoA 2 , apoC 2 and apoB . ^^^ Utilizing cDNA as hybridization probes , we have localized apoA 1 , apoA 2 , apoC 2 , apoC 3 , apoE and apoB to specific locations of individual chromosomes ( for review , see ref . 6 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A search for association with risk or `` anti risk ' ' factor levels was conducted with the following quantitative parameters : total cholesterol , HDL cholesterol , triglycerides , apolipoprotein AI ( apoA 1 ) , apolipoprotein B ( apoB ) and Lp ( a ) lipoprotein levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After 28 days of estrogen there were also significant increases in HDL cholesterol ( 21 % ) , HDL 2 cholesterol ( 42 % ) , apoA 1 ( 37 % ) , and apoA 2 ( 9 % ) , and a decrease in apoB ( 11 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A prospective study of 25 male shift and day workers , who were followed for six months , indicated that the diet of shift workers might be responsible for changes in the ratio between apoB and apoA 1 , a ratio which is related to risk of coronary disease . ^^^ The change in the ratio between apoB and apoA 1 correlated inversely with the change in intake of dietary fibre . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However , cholesterol rich liposomes stimulated secretion of newly synthesized apoE , but not apoB , while apoA 1 secretion was variably affected . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Steady state conditions of lymph flow , triglyceride , and apoA 1 and apoB secretion rates were achieved in hours 3 5 after the start of the infusion . ^^^ With lipid infusion there were the expected increases in secretion rates of triglyceride , apoB , and apoA 1 both in whole lymph and in the d less than 1 . 006 g / ml lipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The two major apolipoproteins of badger serum , apoA 1 and apoB , have been isolated and characterized . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Maximal increases in apolipoprotein AI and CII ( apoAI and apoCII ) secretion can be obtained with initial concentrations of hormone of 20 nM or greater , while a similar induction of apoB and apoE requires in excess of 500 nM . ^^^ Analyses of the kinetics of accumulation of the apolipoproteins in response to high concentrations of hormone indicate that induction of apoB and apoE occurs coordinately , but it lags behind that of apoAI and apoCII by 5 6 hr . ^^^ The ability to induce apoAI and apoCII and the kinetics with which they respond to low levels of estrogen correlate with levels of nuclear type 1 estrogen binding sites , while increases in apoE and apoB synthesis in response to high concentrations of hormone correlate with the induction of type 2 sites . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
FF 1 levels of CH , triglycerides ( TG ) , phospholipids ( PL ) , apolipoprotein A 1 and B ( apoA 1 ; apoB ) , oestradiol and progesterone were assayed in both groups as were the corresponding serum levels in the stimulated patient group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Persons with elevated apoB had normal to high levels of total serum cholesterol and triglyceride and low to normal levels of high density lipoprotein and apolipoprotein A 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The serum levels of apolipoprotein A 1 ( ApoA 1 ) and apolipoprotein B ( ApoB ) were assessed by electroimmunoassay in 19 bilaterally oophorectomised women before and after treatment with 2 and 4 mg oestradiol valerate ( E2V ) daily . ^^^ The increased levels of ApoA 1 and the decreased levels of ApoB seen after the cross over study were not found to have altered after this treatment duration evaluation . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Because lipoproteins containing apolipoprotein A ( ApoA 1 + ApoA 2 ) or apolipoprotein B ( ApoB ) seem to exert opposite effects as risk factors for coronary heart disease , we decided to determine the separability of these two major plasma lipoproteins by procedures originally designed to separate high density from low and very low density lipoproteins . ^^^ The ApoB containing lipoproteins isolated by other procedures always contained 4 % to 20 % of total plasma ApoA 1 and differed substantially from one another with respect to the content of some of the minor apolipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein E and apoA 1 were present in human and canine CSF , but apoB could not be detected . ^^^ The expression of apoB , E ( LDL ) receptors by brain cells and the presence of apoE and apoA 1 containing lipoproteins in CSF suggest that the central nervous system has a mechanism for lipid transport and cholesterol homeostasis similar to that of other tissues . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Results were 109 % for apoA 1 and 101 % for apoB as compared with those measured for IUIS WHO reference materials from the Centers for Disease Control . ^^^ Recovery averaged 103 % for apoA 1 and 105 % for apoB , for duplicate assays of three concentrations of purified apoA 1 and low density lipoprotein ( LDL ) . ^^^ Assaying sera from 45 patients , we demonstrated a good correlation between INA and radial immunodiffusion for both apoA 1 ( r = 0 . 92 ) and apoB ( r = 0 . 95 ) . ^^^ Correlations between apoA 1 and high density lipoprotein cholesterol , and between apoB and LDL cholesterol compared favorably with previous reports . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Treatment of differentiated monolayers with calcium ionophores A 23187 or ionomycin caused dose specific increases ( 125 % at 1 microM ) in the accumulation of total apoB , but not apoA 1 , in conditioned medium as measured by specific immunoassays . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The reduced plasma levels of LDL and HDL cholesterol , and of both plasma apoB and apoAI , were associated with increased fractional catabolic rates of these apolipoproteins in LDL and HDL . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Two international apolipoprotein A 1 and B ( apoA 1 and apoB ) surveys were conducted in 1983 and 1986 with use of a lyophilized serum measured by 55 and 91 participants , respectively . ^^^ Comparing the 1986 with the 1983 findings , we saw a 60 % decrease in apoA 1 variability among laboratories , and a similar decrease ( 53 % ) was found for apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The first order rate constants for transit of apoB , apoA 1 , and apoII through the endoplasmic reticulum ( ER ) and Golgi were estimated using a three compartment ( ER , Golgi , and extracellular medium ) kinetic analysis . ^^^ ApoA 1 transits the ER at a rate ( t1 / 2 = 6 min ) much faster than apoB , apoII , and virtually all other secretory proteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Furthermore , they obtained evidence for the occurrence in human plasma of small amounts of lipoproteins containing apoA 2 but not apoA 1 , apoB , apoC 2 , apoC 3 or apoE . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoB and apoAI are compared to total cholesterol and to lipoprotein lipids as predictors of CAD . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Intracellular apoA 1 and apoB distribution in rat intestine is altered by lipid feeding . ^^^ ApoB and apoA 1 mass are determined by radioimmunoassay and newly synthesized apolipoprotein characterized following [ 3H ] leucine intraduodenal infusion . ^^^ Intracellular chylomicron , VLDL , low density lipoprotein ( LDL ) , and HDL fractions were isolated and found to contain apoB , and apoA 4 , and apoA 1 . ^^^ In the fasted animal , less than 10 % of total intracellular apoB and apoA 1 was bound to lipoproteins and 7 % of apoB and 35 % of apoA 1 was contained in the d 1 . 21 g / ml infranatant . ^^^ Lipid feeding doubled the percentage of intracellular apoA 1 bound to lipoproteins and increased the percentage of intracellular apoB bound to lipoproteins by 65 % . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We found that liver is the sole or major site of synthesis of apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , and apoE , and the intestine is a major site of synthesis of apoA 1 , apoA 4 , and apoB . ^^^ Minor sites of apolipoprotein mRNA synthesis were as follows : apoA 1 , liver and skeletal muscle ; apoA 4 , spleen and lung ; apoB , kidney ; apoC 2 and apoC 3 , intestine . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma triglyceride , total cholesterol , very low density lipoprotein cholesterol , and apoB levels were higher , and apoA 1 and high density lipoprotein cholesterol were lower in the postmenopausal group , but these differences were not significant at P less than 0 . 05 . ^^^ Controlling for age and body mass index effects significantly reduced the differences in total cholesterol , LDL cholesterol , apoB , and LDL particle size and broadened the differences in apoA 1 and high density lipoprotein cholesterol . ^^^ Plasma cholesterol , triglyceride , lipoprotein cholesterol , and apolipoprotein A 1 and B ( apoB ) concentrations , as well as low density lipoprotein ( LDL ) particle size ( LDL 1 7 ) , as assessed by 2 16 % polyacrylamide agarose gradient gel electrophoresis , were determined in 87 premenopausal and 43 postmenopausal women . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The reactions of antibodies to apoA 1 , apoA 2 , apoE , apoB , apoD , and apoA 4 have revealed discrete bands of particles which differ widely in size and apolipoprotein composition . ^^^ GGE of centrifugally prepared LDL shows the presence of apoB , apoE , and apoD , but not that of apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Furthermore , neither laying hen HDL which contain apoII and apoA 1 nor apoII / PC were able to displace receptor bound apoB containing lipoproteins , as shown in competitive binding assays as well as by ligand blotting . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma triglyceride increased then decreased postprandially , while plasma apoA 1 and apoB concentrations decreased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
When compared to the high saturated fat diet , the AHA Phase 2 diet significantly reduced total , low density lipoprotein ( LDL ) , and high density lipoprotein ( HDL ) cholesterol , apoB , and apoA 1 levels , and improved the LDL / HDL cholesterol ratio , whereas the intermittent saturated fat diet lowered total and LDL cholesterol and apoB levels , and also improved the LDL / HDL cholesterol ratio . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The d less than 1 . 006 g / ml fraction was found to contain all of the major apolipoproteins , while the LDL fraction contained primarily apoB 100 and apoE ; the HDL ( 1 . 063 less than d less than 1 . 21 g / ml ) fraction principally contained apoA 1 and apoA 4 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In patients with type 1 diabetes without clinical signs of CHD , LP spectrum values including the content of apo AI , apo B and the ratio of apoB / apo AI did not differ from those of the controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Immunoprecipitation demonstrates that all the major apoproteins are synthesized , including both forms of apoB , apoE and apoA 1 . ^^^ Particles of all density classes are formed , apoB associating with the lighter particles and apoA 1 with the heavier . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apoprotein A 1 ( apoA 1 ) was higher in football players ( 1 . 5 + / . 06 vs 1 . 16 g / l , P less than . 001 ) , while the apoprotein B ( apoB ) was lower ( . 6 + / . 03 vs . 88 + / . 04 g / l , P less than . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Changes of the plasma lipid , lipoprotein and apoprotein parameters relative to the corn diet were as follows : the corn+ diet significantly increased total plasma cholesterol , HDL cholesterol , LDL cholesterol , and apoB levels ; the lard diet significantly increased total cholesterol , HDL cholesterol , and apoB ; and the lard+ diet significantly increased the total cholesterol , HDL cholesterol , LDL cholesterol , and apoA 1 and apoB levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
CRF patients had reduced concentrations of ApoA 1 and ApoA 2 , normal levels of ApoB and ApoC 1 , and increased concentrations of ApoC 2 and , in particular , of ApoC 3 . ^^^ In comparison with type 4 , hyperlipoproteinemic patients , CRF patients had lower concentrations of ApoA 1 , ApoA 2 , ApoB , ApoC 1 and , particularly , ApoE ; there was no difference in ApoC 3 levels reflecting the hypertriglyceridemia common to both disorders . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ApoB level was significantly higher in the CI patients but there was no significant difference between the 2 groups in the levels of the other apolipoproteins ( ApoA 1 , A 2 , C 2 , C 3 , and E ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 and ApoB levels were higher at 3 days in FF , but ApoC 3 levels were the same . ^^^ For the infants as a group , changes in levels with increasing age were similar for both ApoA 1 and cholesterol esters , as was the case for ApoB and triacylglycerols . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Kinetic heterogeneity for apoA 1 , apoA 2 , apoB , apoC 2 and apoC 3 have been established . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Noninsulin dependent diabetics , whose plasma contained no detectable beta VLDL ( very low density lipoprotein ) , had a proportion ( 0 . 23 + / 0 . 04 ) of plasma apolipoprotein E in the form of an abnormal lipoprotein not recognized by antibodies to apoB 100 from LDL ( low density lipoprotein ) or apoA 1 from HDL ( high density lipoprotein ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis of [ 35S ] methionine labeled Caco 2 lipoproteins revealed that very low density lipoproteins contain apolipoprotein E ( apoE ) and C apolipoproteins , while low density lipoproteins contained apoB 100 , apoE , apoA 1 , and C apolipoproteins . ^^^ The high density lipoproteins contained apoA 1 , apoB 100 , apoB 48 , apoE , and the C apolipoproteins . ^^^ ApoA 1 , apoB , and apoE were visualized in Caco 2 cells by immunolocalization analysis . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Results showed that patients with GSD 1 have a unique apolipoprotein profile characterized by normal or slightly decreased levels of ApoA 1 and ApoA 2 , reduced concentrations of ApoD , and significantly increased levels of ApoC 1 and ApoC 2 ( p less than 0 . 01 ) and ApoB , ApoC 3 , and ApoE ( p less than 0 . 0001 ) in comparison with age and sex matched normolipidemic controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Whole plasma apoE and apoA 1 concentrations were decreased and apoB increased due to cholesterol feeding as determined by electroimmunoassay , but again gemfibrozil treatment prevented these diet induced alterations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
This interaction was attended by a gradual loss of the surface components of HDL , namely apoA 1 , phospholipids , and unesterified cholesterol , and by the appearance of two cholesteryl ester rich lipoproteins of d 1 . 019 1 . 024 g / ml and d 1 . 038 1 . 058 g / ml containing apoA 1 and proteins with electrophoretic mobilities of apoB , apoE , and apoA 4 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Baseline values of ApoA 1 in wrestlers , weightlifters , boxers and judokas were slightly higher as compared to `` normal ' ' population ; ApoB was clearly reduced ( mean value of 690 mg / l ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
When the HDL fraction ( 1 . 07 1 . 21 g / ml ) was subjected to isopyknic density gradient ultracentrifugation , a peak of apoproteins A 1 and B ( apoA 1 and apoB , respectively ) was found at a density of 1 . 11 1 . 14 g / ml . ^^^ Immunoelectrophoresis revealed a precipitin arc in the alpha region against apoA 1 which extended into the pre beta region where a precipitin arc against apoB was also seen . ^^^ The newly synthesized apoproteins of the HDL fraction , as determined by gel electrophoresis , were apoB , apoA 1 , and apolipoprotein A 4 ( ApoA 4 ) . ^^^ Immunoprecipitation of the apoB particles revealed apoA 1 and apoA 4 in the supernatant . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Secretion of cholesterol and apoA 1 , but not apoB , from the liver and intestine was lower in rats fed soybean PL . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The major apolipoproteins include apoE , apoB , apoA 1 , apoA 2 , apoA 4 , apoC 1 , apoC 2 , and apoC 3 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Levonorgestrel + EE induced significant increases in total triglycerides ( 48 % ) , apoB ( 19 % ) and the ratio apoB / apoA 1 ( 18 % ) and no significant changes in HDL cholesterol ( 8 % decrease ) , apoA 1 , % HDL cholesterol , total cholesterol and serum glycosylated proteins . ^^^ Desogestrel + EE induced significant increases in HDL cholesterol ( 12 % ) , % HDL cholesterol ( 15 % ) , triglycerides ( 35 % ) and apoA 1 ( 20 % ) , no changes in total cholesterol , apoB and glycosylated serum proteins and a significant decrease in the ratio apoB / apoA 1 ( 17 % ) . ^^^ The differences between the effects of the two preparations on the parameters HDL cholesterol , % HDL cholesterol , apoA 1 , apoB and the ratio apoB / apoA 1 were statistically significant and can be explained by a difference in the intrinsic androgenicity of the two progestagens . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
C . ) 209 , 497 499 ] , synthesize and secrete into the culture medium most of the major plasma apoproteins ( apoA 1 , apoA 2 , apoB , apoC 2 , apoC 3 , and apoE ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Radioiodinated VLDL and HDL kinetic data indicated increased VLDL apoB ( 86 . 1 % rise ) and HDL apoA 1 ( 24 . 9 % rise ) synthesis during estrogen administration . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Intra assay precision ( CV ) was 4 . 7 % for ApoA 1 , 7 . 8 % for ApoB in the `` rocket ' ' electrophoresis . ^^^ Interassay precision ( CV ) was 6 % for ApoA 1 and 8 % for ApoB . ^^^ After lung resection , the concentration of ApoA 1 in serum was significantly decreased ( p less than 0 . 001 ) and that of ApoB significantly increased ( p less than 0 . 001 ) as compared with controls . ^^^ ApoA 1 and ApoB concentrations were unchanged in chronic obstructive pulmonary disease . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
By immunoaffinity chromatography , all the apoE of native plasma was present in the form of complexes also containing either apoA 1 or apoB . ^^^ These forms were derived mainly or exclusively from the dissociation of apoE from lipoproteins containing apoB , while apoE bound to apoA 1 was dissociated by neither procedure . ^^^ When lipoproteins were adsorbed on immobilized antibodies to apoA 1 or apoB and dissociated with 3 M NaCNS , the apoE and apoA 1 remained associated while the complex of apoB and apoE was substantially dissociated . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The data reviewed here indicate that the measurement of the plasma level of the major apoproteins of LDL and HDL , apoB and apoA 1 , respectively , provide additional information in the assessment of a patient at risk for CAD . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Male relatives of the CAD patients had significantly higher serum triglyceride and apoB levels , and significantly lower serum HDL C and apoA 1 levels than the controls . ^^^ Female relatives of the CAD patients also showed similar differences in serum HDL C , apoA 1 and apoB levels . ^^^ In univariate analysis , the best discriminator was apoB between male relatives and the controls , and apoA 1 between female relatives and the controls . ^^^ By adding variables of apoA 1 and apoB , the percentage of correctly classified subjects was increased to 82 % and 80 % , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There is a strong genetic effect on serum level of apoB , apoA 1 and apoA 2 , a weaker effect on cholesterol level and a doubtful effect on triglyceride level . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
HDL C , apoA 1 , apoB and the apoA I / apoA 2 ratio were significantly increased in the Type 1 patients , whereas the VLDL C / VLDL TG and LDL C / apoB ratios were decreased significantly . ^^^ Type 1 diabetics in ' fair ' metabolic control presented higher values of TG , VLDL C , VLDL TG and apoB than patients in ' good ' control : lower values of apoA 1 and of the ratios apoA I / apoA 2 , apoA I / apoB and LDL C / apoB were recorded in the same subgroup . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Hyperlipidemia in leukemia may be more prevalent than previously realized since nine other cases of newly diagnosed ALL have been studied who had moderate hypertriglyceridemia associated with elevated ApoB and low ApoA 1 levels , but normal triglyceride composition . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Following lipolysis the lipoproteins lost nearly all their triglycerides , apoA 1 , and apoC , and were relatively enriched with cholesteryl esters , unesterified cholesterol , phospholipids , and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The lipoproteins of whole plasma were fractionated in a continuous manner by molecular sieve chromatography using 4 % agarose and the elution profile of apoE was compared to that of apoB , apoA 1 , cholesterol , and triglyceride . ^^^ The other two , however , are distinct in size from the major cholesterol carrying LP ; fraction 2 is intermediate in size between VLDL and the major apoB containing lipoprotein , LDL ; and fraction 3 is larger than the major apoA 1 containing lipoproteins , HDL , but smaller than LDL . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Murine apoA 1 and apoB like proteins of higher ( apoBH ) and lower ( apoBL ) molecular weight were constituents of the d 1 . 033 1 . 046 g / ml fraction . ^^^ Alternative techniques , such as electrophoresis in starch block , are therefore a prequisite for separation of apoB from alpha migrating , apoA 1 containing lipoproteins in the low density range in mouse serum . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were no significant differences in plasma cholesterol , HDL cholesterol , apoA 1 and apoB levels between the types of beef ( F Bf vs . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The dietary PE , but not PC , caused a decrease in serum cholesterol , phospholipid , apolipoprotein A 1 ( apoA 1 ) and apoE and an increase in high molecular weight apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
This was confirmed by the demonstration of a `` new ' ' particle which contained apoA 1 , apoA 2 , and apoE , but no apoB or Lp ( a ) antigen . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma lipids and 6 plasma apolipoproteins ( apoA 1 , apoA 2 , apoB , apoC 1 , apoC 2 and apoC 3 ) were studied in 23 patients with nephrotic syndrome . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Feeding soy protein resulted in a significant decrease in serum apoA 1 and apoB , but the relative concentration of high density lipoprotein cholesterol was kept at the higher level . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Estimates of heritability were 0 . 54 for serum cholesterol , 0 . 32 for VLDL + LDL cholesterol , 0 . 78 for HDL cholesterol , 0 . 56 for apoA 1 , and 0 . 20 for apoB concentration . ^^^ Genetic ( rg ) and environmental ( re ) correlations among serum cholesterol , lipoprotein cholesterol , and apoprotein concentrations were positive except for the negative genetic relationships of apoA 1 with apoB ( rg = 0 . 74 ) and with VLDL + LDL cholesterol ( rg = 0 . 30 ) concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Storage of sera at 85 degrees C for 1 yr seems not to have influenced the results of determinations of serum cholesterol and triglycerides , apoA 1 , and A 2 , but may have caused differences observed in apoB between the two months of May 1978 and 1979 . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The plasma concentrations of ApoB declined from base line values of 80 . 3 mg / dl to 54 . 6 mg ( mono ) , 51 . 8 mg ( poly ) , and 59 . 6 mg ( sat ) while Apo CIII and Apo AI did not show any changes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoB significantly decreased in the 3 groups while apoA 1 increased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Dietary cholesterol after infancy significantly increased serum total cholesterol , VLDL + LDL and HDL cholesterol , apoA 1 and apoB concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
LDL apoB concentration was decreased by 41 % while HDL was deficient in apoA 1 , A 2 and A 4 , and C . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After 12 months of GH treatment , the total cholesterol , LDL cholesterol , and apoB concentrations decreased , the HDL cholesterol and apoE concentrations increased , and the apoA 1 and triglyceride concentrations were unchanged . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS Lp ( a ) , apoB , triglycerides , and total and LDL cholesterol were higher ( P < 0 . 001 ) and apoA 1 was lower ( P = 0 . 03 ) in normoalbuminuric IDDM patients than in healthy control subjects . ^^^ In multivariate analysis , with log AER as the dependent variable , apoB / apoA 1 , systolic blood pressure , age , and IGF 1 but not Lp ( a ) added to the regression ( r 2 = 0 . 47 , P < 0 . 0001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Linkage analyses with penetrance parameter estimates from the segregation analysis excluded tight linkage between the detected major locus and markers for the following candidate loci : the apoAI / apoCIII genomic region ( P < . 05 ) , apoB ( P < . 01 ) , hepatic lipase ( P < . 001 ) , lipoprotein lipase ( P < . 001 ) , and the LDL receptor ( P < . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In addition , each of the size measures was correlated with a variety of measures of HDL and beta lipoprotein concentrations , which included HDL C , LDL C , triglycerides , and apoAI , apoB , and apoE . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In addition to increased LDL levels , overexpression of human apoB in rabbits resulted in lower plasma levels of HDL cholesterol and apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
It was the aim of this study to 1 ) compare the effects of glucose and other hexoses with that of oleate on secretion of apolipoproteins ( apos ) A 1 and B by HepG 2 cells , and 2 ) document the effect of various metabolic inhibitors on the secretion of these apos in the absence or presence of extra glucose / oleate . 1 ) The addition of 10 mM glucose increased secretion of apoA 1 and apoB , as measured by enzyme immunoassay , by about 60 % when cells were incubated for 48 h in DMEM + 10 % fetal calf serum . ^^^ However , in a pulse chase experiment ( 15 min labeling , 2 h chase ) , glucose was found to increase apoA 1 synthesis but not apoB synthesis . ^^^ In contrast , the addition of 0 . 5 mM oleate had a weak inhibitory effect on secretion of apoA 1 whereas it increased the secretion of apoB by more than twofold . ^^^ The combination of 10 mM glucose and 0 . 5 mM oleate had no greater effect than glucose alone on apoA 1 secretion but increased apoB secretion by fourfold . 2 ) Inhibiting glycolysis ( by glucosamine ) lowered secretion of both apoA 1 and apoB , while inhibiting lipogenesis ( using 8 Br cyclic AMP or 5 ( tetradecyloxy ) 2 furancarboxylic acid ( TOFA ) ) did not affect apoA 1 secretion but clearly decreased that of apoB . ^^^ Actinomycin D also suppressed basal secretion of apoA 1 but surprisingly stimulated that of apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Using a multivariate analysis , we found that ( 1 ) genotypes of APOB , PON , LPL , LDLR , and APOE were significantly associated with variation of plasma apo B related traits ; ( 2 ) genotypes of PON , LPL , and APOC 3 were significantly associated with variation in plasma triglycerides ; and ( 3 ) genotypes of VLDLR , APOC 3 , LDLR , and APOE were significantly associated with variation in plasma apo AI and HDL cholesterol . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Polymorphisms at the apoB , apoA 1 , and cholesteryl ester transfer protein gene loci in patients with gallbladder disease . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Compared with simvastatin monotherapy , combined drug therapy induced further reductions in triglycerides ( by 26 % , p = 0 . 0003 ) and apoB ( by 11 mg / dl , p = 0 . 03 ) and an increase in apoA 1 ( by 21 mg / dl , p = 0 . 0008 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoAI , APOAII and ApoB , Lp ( a ) and fructosamine . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Differentiated post confluent CaCo 2 cells were incubated for 24 72 h in serum free medium in the presence or absence of 5 microM lovastatin , and the secretion rate of lipids , as well as apoB and apolipoprotein AI ( apoAI ) into the medium , was measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The major apolipoproteins of LDL and high density lipoprotein ( HDL ) , apoB and apoA 1 respectively , and levels of Lp ( a ) lipoprotein are often abnormal in children born in a family with premature coronary artery disease ( CAD ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
On ligand blots , LPL bound to amino terminal fragments of apoB generated by thrombin digestion but not to apoA 1 , apoE , or carboxyl terminal fragments of apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma apoB levels increased significantly , 0 . 93 mg / dL per 100 mg / d dietary cholesterol ( P = . 025 ) , whereas apoA 1 levels tended to rise ( 1 . 35 mg / dL per 100 mg / d , P = . 056 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We reported earlier that a complex familial hypercholesterolemia ( c FHC ) phenotype characterized by elevated levels of total plasma cholesterol ( TC ) and apoB and reduced levels of HDL cholesterol ( HDL C ) and apoA 1 is associated with the development of spontaneous atherosclerotic lesions in swine . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In apoA 1 deficiency and TD , however , [ 3H ] UC is esterified in lipoproteins free of apoA 1 and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To address this issue , ceruloplasmin , copper , iron , ferritin , cotinine , lipid peroxides , cholesterol , triglyceride , apoB , apoA 1 , and lipoprotein ( a ) levels were measured in sera from apparently healthy subjects ( 51 men and 115 women ) . ^^^ Pairwise comparisons revealed strong positive associations ( P < . 001 ) of copper and ceruloplasmin with lipid peroxides , total cholesterol , triglycerides and apoB , of transferrin with apoA 1 and cholesterol , and of ferritin with triglycerides . ^^^ Copper and ceruloplasmin accounted for 20 . 5 % of the variation in triglyceride levels ; triglycerides and apoB accounted for 12 % of the variability in ferritin levels ; apoB and apoA 1 accounted for 9 % of the variability in transferrin levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To further understand the effect of pregnancy on other metabolic parameters , we compared the relative levels of apolipoproteins such as apolipoprotein A 1 ( apoA 1 ) and apolipoprotein B ( apoB ) , lipoprotein ( a ) ( Lp ( a ) ) and blood sugar during and after pregnancy . ^^^ We found that apoB concentration progressively increased with advancing gestation , while the levels of apoA 1 , Lp ( a ) and blood sugar were independent of gestation process . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The functional properties of the apolipoproteins ( apoB and apoA 1 ) governing lipoprotein metabolism make these variables conceptually important as markers for coronary artery disease risk . ^^^ White children , especially boys , showed lower concentrations of apoA 1 and ratios of cholesterol to apoB within low density lipoprotein ( LDL ) than did black children . ^^^ Further , the impact of apoE genotypes on apoB and apoA 1 levels is already evident in childhood . ^^^ Low values for apoA 1 concentration , the apoA 1 to apoB ratio , and LDL cholesterol to apoB ratio in children are strongly related to parental incidence of myocardial infarction ; no such relationship is seen with respect to lipoprotein cholesterols . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The characteristic disorder of serum apos in NS was a decrease in apoAI and AII and a significant increase in apoB , CII , and CIII . ^^^ Consequently , the ratio of apoAI to apoB was significantly decreased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The purpose of the present study was : 1 ) to elucidate the metabolic basis of the low apoA 1 levels in ABL ; 2 ) to determine whether in vivo apoE production rates are normal in the absence of apoB lipoprotein secretion ; and 3 ) to test the hypothesis that apoE influences apoA 1 and HDL catabolism in ABL . 131I labeled apoA 1 and 125I labeled apoE were reassociated with autologous lipoproteins and injected into two unrelated ABL patients and control subjects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Blood insulin , apoA 1 and apoB were not altered postprandially by cholesterol intake . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At day 4 the amount of 35S labeled apoB containing lipoproteins ( VLDL LDL ) secreted into the medium was 1 . 7 and 1 . 5 times that found at days 0 and 7 , respectively ; the radioactivity incorporated into medium HDL ( containing predominantly apoA 1 ) was 1 . 7 times that found at days 0 and 7 . ^^^ To define whether the changes in the production of apoA 1 and apoB containing lipoproteins were due to variations in apoB and apoA 1 synthesis , the initial synthetic rate ( pulse labeling ) and the mRNA content of these apolipoproteins were investigated . ^^^ In conclusion the increased hepatic CE content at hatching reflects a decreased production of apoB , while the depletion of CE observed from day 2 to day 7 is associated with an increased production of both apoB and apoA 1 containing lipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
DESIGN AND PATIENTS : Serial Lp ( a ) , apoB and apoA 1 determinations were obtained over eight days in 19 AMI patients who were part of a randomized , placebo ( n = 7 ) controlled trial of tPA ( n = 12 ) . ^^^ At 192 h postinfarct , Lp ( a ) rebounded to 36 % above baseline ( 24 . 9 + / 3 . 0 to 33 . 9 + / 3 . 9 mg / dL , P < 0 . 05 ) , apoB returned to baseline ( 1 . 37 + / 0 . 10 versus 1 . 33 + / 0 . 11 g / L , P < 0 . 05 ) and apoA 1 was 15 % below baseline ( 1 . 43 + / 0 . 06 to 1 . 21 + / 0 . 06 g / L , not significant ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
An 8 month old boy with chronic diarrhea and failure to thrive was found to have abnormally low plasma total cholesterol ( 85 mg / dl ) , LDL cholesterol ( 48 mg / dl ) , apoB ( 52 mg / dl ) , apoA 1 ( 53 mg / dl ) , and vitamin E ( 0 . 22 mg / dl ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Maximum likelihood linkage analyses were performed to test for linkage between serum apoB levels and several candidate gene markers including apolipoprotein B , lipoprotein lipase , hepatic lipase , cholesterol ester transfer protein , and apolipoprotein AI in a large pedigree . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The CVs for the rate INA and RID measurements were : apoA 1 , 4 . 5 7 . 7 % and 2 . 5 7 . 6 % , respectively ; apoB , 2 . 3 5 . 3 % and 2 . 3 6 . 4 % , respectively . ^^^ In NHANES 3 , rate INA values ( 10 ) can be transformed to WHO IFCC Reference Material based values ( y ) as follows : for apoA 1 , y = 0 . 87x + 251 . 8 mg / L ( r = 0 . 93 , SEslope = 0 . 13 , SEintercept = 17 , n = 708 ) ; for apoB ( mg / L ) , y = 1 . 068x + 112 . 8 mg / L ( r = 0 . 98 , SEslope = 0 . 08 , SEintercept = 7 , n = 646 ) . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Similar reductions in body mass index and plasma triglycerides and increases in apolipoprotein A 1 were seen with both treatments , but HbA 1 was reduced more during treatment with enalapril than with nifedipine ( 0 . 49 vs . 0 . 20 % , P = 0 . 035 ) and serum apolipoprotein B ( apoB ) also declined more with enalapril than with nifedipine ( 8 . 2 vs . 2 . 3 mg / dl , P = 0 . 009 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Furthermore , at a concentration of nonparenchymal cell conditioned media that inhibited apoA 1 mRNA levels by > 80 % compared to control , there were only slight changes in apoB , apoE , LDL receptor , LCAT , 7 alpha hydroxylase , hepatic lipase , HMG CoA reductase , and albumin mRNA levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After this treatment period , the drug group was characterized in comparison with the placebo group by significantly reduced levels of total cholesterol ( 33 % ) , triglycerides ( 30 % ) , very low density lipoprotein cholesterol ( 36 % ) , low density lipoprotein cholesterol ( 43 % ) , apoB ( 36 % ) , apoC 3 ( 18 % ) , and apoE ( 17 % ) and slightly but insignificantly increased levels of high density lipoprotein cholesterol ( 6 % ) and apoA 1 ( 1 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NIDDM subjects also have altered apolipoprotein concentrations , including increased apoB , apoC 3 , and decreased apoA 1 ; in addition , apoE 2 may be over represented in diabetic populations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The decrease in MAWS ( progression of CAD ) was significantly correlated with in trial plasma concentrations of cholesterol ( P = 0 . 002 ) , low density lipoprotein ( LDL ) cholesterol ( P = 0 . 001 ) , apolipoprotein B ( apoB ) ( P = 0 . 008 ) , and lipoprotein ( a ) [ Lp ( a ) ] ( P = 0 . 004 ) ; no significant associations were found with high density lipoprotein ( HDL ) cholesterol , apoA 1 , vitamin E , thyroid hormones , fibrinogen , von Willebrand factor , or post load plasma glucose and insulin concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
These genes include those encoding various apolipoproteins ( apo ) , including apoA 1 , apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , apoE , and apo ( a ) , cholesteryl ester transfer protein ( CETP ) , HDL binding protein , lipoprotein lipase , and the low density lipoprotein ( LDL ) receptor . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At the end of each dietary period , plasma and lipoprotein lipids , apoB , apoA 1 , and hepatic mRNA levels for apolipoproteins were measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The Atherosclerosis Risk in Communities study provided general populations of 7261 men and women free of cardiovascular symptoms for evaluating the associations between intima media thickening in extracranial carotid arteries measured using ultrasound imaging and fasting plasma LDL C , high density lipoprotein cholesterol ( HDL C ) , apoB , apolipoprotein A 1 ( apoA 1 ) , triglycerides , and HDL density subfractions . ^^^ Lipid factors show approximately linear associations with carotid thickness : positive for LDL C and plasma apoB and negative for HDL C and apoA 1 levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were no significant differences in HDL apolipoprotein ( apo ) A 1 or low density lipoprotein apoB between the drugs , but atenolol decreased the ratio of HDL C to apoA 1 , and doxazosin increased this ratio , differences that were statistically significant ( P < . 002 ) . ^^^ Neither apoA 1 nor apoB concentration at baseline nor apoE phenotype was predictive of the lipid responses during antihypertensive treatment with either drug . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Overall fasting values were [ mean ( standard deviation ; SD ) ] cholesterol 4 . 5 ( 0 . 8 ) mmol / L , HDL cholesterol 1 . 5 ( 0 . 4 ) mmol / L , LDL cholesterol 2 . 6 ( 0 . 8 ) mmol / L , apoA 1 1 . 5 ( 0 . 3 ) g / L , apoB 1 . 0 ( 0 . 4 ) g / L and triglycerides 0 . 76 ( 0 . 38 1 . 51 ) mmol / L , the values for triglycerides being mean ( 95 % confidence intervals ) . ^^^ Triglycerides rose and HDL cholesterol fell following feeding and inconsistent effects were seen on apoA 1 and apoB . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Taurocholic acid decreased the secretion of newly synthesized apoB by increasing the rate of apoB degradation , but had no effect on the synthesis and secretion of apoA 1 or trichloroacetic acid precipitable proteins . ^^^ Phosphatidylcholine increased apoB synthesis and secretion without affecting the synthesis or secretion of apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We applied restriction fragment length polymorphisms ( RFLPs ) for apolipoprotein ( apoAI , apoCIII , apoAIV , apoCI , and apoB ) genes to analyze differences between Japanese and Caucasian in allele frequencies as well as those between normal Japanese subjects and patients with coronary artery disease confirmed with coronary arteriography . ^^^ There was a significant ( p < 0 . 01 ) difference between the normal subjects ( with arteriographically confirmed absence of stenosis in all coronary branches ) and those with severe coronary artery disease ( 50 to 100 % stenosis in at least one branch ) in plasma levels of apoAI , apoB , total cholesterol , HDL cholesterol , and LDL cholesterol . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Levels of cholesterol , triglycerides , apolipoprotein A 1 ( apoA 1 ) and B ( apoB ) were measured in total plasma and lipoprotein fractions ( very low density lipoprotein [ VLDL ] , intermediate density lipoprotein [ IDL ] , low density lipoprotein [ LDL ] , and high density lipoprotein [ HDL ] : HDL 2 and HDL 3 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The aim of the study was to investigate the plasma levels of apoB and apoA 1 as structural proteins of low and high density lipoproteins , in relation to apoE phenotypes during the first year of life . ^^^ The concentrations of apoB and apoA 1 in capillary plasma as well as the apoE phenotype were estimated in 199 newborns ( 7 days old ) and in follow up investigations of a subgroup of 45 at 1 , 4 , 12 , 24 , and 52 weeks . ^^^ The plasma concentrations of apoB and apoA 1 in the newborns ( 7 days old ) averaged 55 % of the adult value and increased toward the end of the first year of life up to approximately 85 % . ^^^ The course of the plasma concentrations of apoB and apoA 1 in relation to the apoE phenotype showed that , beginning at 24 weeks , the apoB levels were significantly lower for the phenotype E 2 / 2 and in tendency also for the phenotype E 2 / 3 in comparison with E 3 / 3 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The incidence of the following lipid abnormalities was calculated : hypertriglyceridemia ( n = 49 / 732 , incident cases / subjects free of the particular disorder at baseline ) , high low density lipoprotein ( LDL ) cholesterol level ( n = 43 / 696 ) , low HDL cholesterol level ( n = 33 / 708 ) , high apolipoprotein ( apo ) B level ( n = 72 / 699 ) , low apoAI level ( n = 47 / 711 ) , low serum LDL cholesterol / serum apoB ratio ( n = 55 / 685 ) , and low serum HDL cholesterol / serum apoAI ratio ( n = 48 / 707 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Myristic acid raised low density lipoprotein ( LDL ) cholesterol by 0 . 11 mmol / L , high density lipoprotein ( HDL ) cholesterol by 0 . 12 mmol / L , and apolipoprotein ( apo ) A 1 by 7 . 2 mg / dL relative to palmitic acid ; increases relative to oleic acid were 0 . 50 mmol / L for LDL cholesterol , 0 . 15 mmol / L for HDL cholesterol , 6 . 0 mg / dL for apoB , and 8 . 9 mg / dL for apoA 1 ( P < . 01 for all comparisons ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 , ApoB , and ApoA1 / ApoB before and after combined pancreas kidney transplantation . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MEASUREMENT : At the beginning of the study a determination was made of lipid levels , risk factors such as age , physical activity , tobacco and alcohol use , weight and arterial pressure ; at the end of the first month during vitamin C therapy , and again at the end of the second month without therapy , lipid levels were determined , namely , TG , TC , HDL C , HDL 2 C , HDL 3 C , LDL C , ApoA 1 , ApoB and Lp ( a ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In the eight subjects studied , the values for fasting plasma total , LDL , and HDL cholesterol ; triglycerides ; apoB ; and apoA 1 were essentially identical at the end of each diet period . ^^^ Finally , LDL apoB and HDL apoA 1 turnovers were unaffected by replacement of monounsaturates with polyunsaturates . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipid , ApoB , and ApoA 1 concentrations and distributions in plasma and lipoprotein subfractions . ^^^ The distributions of total cholesterol , apoB , and apoA 1 in plasma lipoprotein subfractions were also examined . ^^^ Compared with NL , FHC had fourfold and 4 . 7 fold increases in total cholesterol and apoB , respectively , distributed in the lower densities ( d < 1 . 043 g / mL ) , and low HDL C and apoA 1 levels , resulting in a high total cholesterol / HDL C ratio ( 14 . 4 : 1 ) and elevated triglyceride levels . ^^^ DHC was characterized by 10 fold and fourfold increases in total cholesterol and apoB , respectively , resulting in an LDL particle highly enriched in cholesterol , a fourfold increase of HDL C , an almost threefold increase in apoA 1 , and a normal triglyceride level . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In both groups , plasma lipid variables were measured , including total cholesterol , triglycerides , high density lipoprotein cholesterol ( HDL C ) low density lipoprotein cholesterol , apolipoprotein ( apo ) AI , apoB , apoAI containing lipoprotein particles without apoAII ( LpAI ) and with apoAII , and apoB containing lipoprotein particles with apoE and with apoCIII . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The main internal factors , or determinants , for plasma alpha tocopherol for nonsupplement users were plasma triglycerides and apoproteins , apoA 1 and apoB , but neither lipids nor apoproteins appeared to affect tocopherol levels in supplement users . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A direct relationship between the plasma apoA 1 : apoB molar ratio and the percentage of alpha tocopherol found in the HDL fraction indicated that a greater proportion of alpha tocopherol associates with HDL as the number of HDL particles in plasma increases relative to LDL particles . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
For these analyses we cloned partial rabbit cDNAs for apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , apolipoprotein E ( apoE ) , cholesteryl ester transfer protein ( CETP ) , hepatic lipase ( HL ) , lipoprotein lipase ( LPL ) , HMG CoA reductase , LDL receptor , 7 alpha hydroxylase , albumin , bile salt dependent cholesteryl ester hydrolase ( CEH ) , lecithin : cholesterol acyl transferase ( LCAT ) , and plasminogen activator inhibitor protein 1 ( PAI 1 ) . ^^^ Messenger RNA levels in isolated liver cell populations normalized to total RNA revealed a cell segregation pattern for hepatic gene expression : parenchymal cells showed higher levels of apoA 1 , apoB , apoE , albumin , LCAT , HL , and 7 alpha hydroxylase mRNAs compared to nonparenchymal cells while nonparenchymal cells showed higher levels of CETP , LDL receptor , HMG CoA reductase , and PAI 1 mRNAs compared to parenchymal cells . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cytokines decreased the concentration of cellular apoA 1 mRNA in a dose related fashion but did not affect cellular concentrations of apoB mRNA . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At the 5 % nominal significance level , the apolipoprotein B locus ( APOB ) was found to be linked to high density lipoprotein cholesterol level ( HDL C ) , low density lipoprotein cholesterol level ( LDL C ) , the ratio HDL C / LDL C , and apolipoprotein AI level times this ratio ( apoAI 10 LDL C / HDL C ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol ( TC ) , high density lipoprotein cholesterol ( C HDL ) , triglycerides ( TRIGL ) , apoprotein A 1 ( apoA 1 ) , and apoprotein B ( apoB ) were assayed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein A 1 ( apoA 1 ) and B ( apoB ) were measured by turbidometry . ^^^ Apolipoprotein A 1 ( apoA 1 ) and B ( apoB ) were measured by turbidometry . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Moreover , these women had serum levels of HDL cholesterol and apoA 1 significantly lower and LDL / HDL and apoB / apoA1 ratio significantly higher than the women without sludge . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Although it is quite true that total blood cholesterol levels in excess of 200 mg / dl ( 5 . 2 mmol / l ) are not automatically dangerous , they nonetheless require complete profiling of cholesterol distribution among the different fractions and , if possible , a complementary study of ApoB , ApoA 1 and Lpa fractions . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We conclude that apoE , as previously observed with apoA 1 and apoB , possesses a T 4 binding domain separate from the lipid binding domain and distinct from both the heparin and the cell receptor binding sites . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To assess the specificity of the estrogen effect , we also compared the responses of apolipoprotein AI ( apoAI ) , apolipoprotein B ( apoB ) , and beta actin to the response of the LDL receptor . ^^^ In male Sprague Dawley rats given 17 beta estradiol or 17 alpha ethinyl estradiol at supraphysiological doses of 5 micrograms / g body mass / day , plasma total cholesterol and triacylglycerols fell to approximately 5 % and approximately 50 % , and , plasma apoAI and apoB fell to approximately 12 % and approximately 16 % of controls , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The amounts of apoA 1 and apoB produced by HepG 2 cells were unaffected by heparin . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Thus , apoB may activate LCAT in a very different manner from apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After adjusting for age , body mass index , and smoking status , women in both Taipei and Framingham had significantly lower mean triglyceride , LDL C , and apoB levels and significantly higher HDL C and apoA 1 levels than men . ^^^ Postmenopausal women in Taipei had significantly higher mean total cholesterol , LDL C , HDL C , apoA 1 , apoB , and Lp ( a ) levels than premenopausal women ( P < . 05 ) , whereas in Framingham postmenopausal women had significantly higher total cholesterol , triglyceride , LDL C , and apoB levels than premenopausal women ( P < . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
These results suggest that synthesis of apoA 4 may lead to the formation of a subclass of HDL with a different metabolic fate than that of lipoproteins containing either apoA 1 or apoB . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
LDL apoB to apoA 1 ratios were significantly reduced when the subjects consumed the vegetable oil enriched diets . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 , apoA 2 , apoA 4 , apoB , apoC 3 , apoD , apoE , apoH , lecithin : cholesterol acyltransferase ( LCAT ) , cholesteryl ester transfer ( CET ) protein , proline rich protein , and a protein of Mr 59 , 000 were detected in the A IVLp . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We found significant differences ( P < 0 . 01 ) in the concentrations of high density lipoprotein cholesterol ( HDLC ) , apolipoprotein AI ( ApoAI ) , apolipoprotein B ( ApoB ) , and lipoprotein ( a ) [ Lp ( a ) ] . ^^^ Concentrations of HDLC < 350 mg / L , ApoAI < 900 mg / L , ApoB > 800 mg / L , and Lp ( a ) > 200 mg / L occurred , respectively , 2 . 8 , 5 . 2 , 1 . 7 , and 2 . 3 times more frequently in the patients than in the control group . ^^^ If one considers HDLC at < 350 mg / L , ApoAI at < 900 mg / L , ApoB at > 800 mg / L , and Lp ( a ) at > 200 mg / L as separate risk factors for CAD , the ratio of individual patients to control subjects having 4 , 3 , 2 , 1 , or 0 risk factors was [ symbol : see text ] 9 . 4 , 2 . 1 , 0 . 2 , 0 . 2 , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However , the ratio apoB / apoA 1 proved higher in the donors with humid ear wax than in those with the dry variant under P < 0 . 06 , which can stimulate this disease . ^^^ The results of this study support the statement that low level of apoB and especially apoB / apoA 1 may be one of the longevity markers . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Thus , the recovery of albumin and ApoA 1 is increased while ApoB removal remains constant , which improves the selectivity of the fractionation stage . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The amounts of triglyceride ( TG ) , cholesterol , apolipoproteins A 1 ( ApoA 1 ) and B ( ApoB ) were measured in each sample . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have previously shown that both kidney alone and combined kidney pancreas transplantation lower VLDL and IDL apoB while increasing LDL apoB , apoA 1 , and HDL free cholesterol ( FC ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In group 1 patients the following lipid profile parameters were also evaluated : low density lipoprotein cholesterol , high density lipoprotein cholesterol , lipoprotein ( a ) , ApoAI , ApoAII , and ApoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Simvastatin at 200 mg / d significantly decreased the levels of TC ( 25 % ) , LDL C ( 27 % ) , lathosterol ( 40 % ) , apoB ( 22 % ) , apoC 3 ( 37 % ) , and apoE ( 24 % ) and modestly decreased the levels of HDL C ( 12 % ) and apoA 1 ( 11 % ) ( percent relative to the average pretreatment and posttreatment baseline values ) but did not affect the levels of TG , VLDL C , the lathosterol / TC ratio , or LCAT activity . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In contrast with serum ApoA 1 variations , serum apolipoprotein B ( ApoB ) levels are stable . ^^^ The assessment of messenger RNA ( mRNA ) levels of ApoA 1 and ApoB using a quantitative competitive polymerase chain reaction ( PCR ) method was performed in 18 alcoholic patients : 8 with normal livers or steatosis ( group 1 ) , 6 with fibrosis or nonsevere cirrhosis ( group 2 ) , and 4 with severe cirrhosis ( group 3 ) . ^^^ There was a significant correlation between serum and mRNA levels of ApoA 1 ( r = . 65 , P = . 003 ) but no correlation between serum and mRNA levels of ApoB ( r = . 19 , NS ) . ^^^ We suggest that ( 1 ) steatosis is associated with increased ApoA 1 mRNA ; ( 2 ) fibrosis is associated with decreased serum ApoA 1 , probably caused by a posttranscriptional mechanism ; ( 3 ) severe alcohol induced cirrhosis is associated with a nonspecific decrease in ApoA 1 and ApoB mRNA ; and ( 4 ) in contrast to ApoA 1 mRNA , the ApoB mRNA level makes a slight contribution to the ApoB serum concentration . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To evaluate the relationship between atherogenic lipid profile and serum albumin in haemodialysis patients we measured fasting serum Lp ( a ) , total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , triglyceride ( TG ) , apoprotein A 1 ( ApoA 1 ) , apoprotein B ( ApoB ) and albumin in 101 haemodialysis patients and in 46 healthy subjects as a control . ^^^ TC , TG , HDL C , ApoA 1 , ApoB , TC / HDL C , and ApoA I / ApoB ratios were not different between group 1 and group 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
It was concluded that the highest correlation with the cerebral atherosclerosis severity degree existed with the level of apoA 1 and apoB apolipoproteins , followed by correlation of LDL and HDL cholesterol , and the lowest correlation was found between HDL and the total cholesterol . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Changes of ApoB , ApoA 1 and Lp ( a ) serum levels did not attain statistical significance but trends were revealed ( e . g . a drop of the ApoB / ApoA1 index ) which are consistent with the expected favourable action of EPC on the CH distribution in lipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A similar profile of estrogen induced proteins was seen with the 3 ' UTRs of the estrogen regulated mRNAs for apoB and vitellogenin 2 , but not with the 3 ' UTRs of the non estrogen regulated mRNAs for apoA 1 and glyceraldehyde phosphate dehydrogenase . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The effect of fenofibrate on plasma cholesteryl ester transfer protein ( CETP ) activity in relation to the quantitative and qualitative features of apoB and apoA 1 containing lipoprotein subspecies was investigated in nine patients presenting with combined hyperlipidemia . ^^^ Fenofibrate ( 200 mg / d for 8 weeks ) induced significant reductions in plasma cholesterol ( 16 % ; P < . 01 ) , triglyceride ( 44 % ; P < . 007 ) , VLDL cholesterol ( 52 % ; P = . 01 ) , LDL cholesterol ( 14 % ; P < . 001 ) , and apoB ( 15 % ; P < . 009 ) levels and increased HDL cholesterol ( 19 % ; P = . 0001 ) and apoA 1 ( 12 % ; P = . 003 ) levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The reduction in B 48 like protein formation was specific to MTP expression ; coexpression with other proteins ( e . g . apoA 1 or apoB 15 ) did not alter B 48 like protein production . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Immunohistochemical analysis showed that apolipoprotein constituents of HDL ( apoA 1 , apoA 2 , and apoE ) , but not apoB , a marker of LDL , accumulated in the affected cornea . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To determine whether the ability to assemble VLDL is governed by apoB length or by sequences beyond apoB 29 , we created chimeric proteins that contained human apoA 1 and a segment derived from between the C terminal 29 and 34 % , 34 and 37 % , or 37 and 42 % of apoB 100 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The fact that plasma triglyceride levels in TrGN rats were also not increased may relate to the failure of hepatic apoB secretion to increase , which in turn may have been due to saturation of the protein synthetic capacity by human apoA 1 production . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We investigated in the chick whether the diet induced changes of the hepatic content of cholesteryl esters ( CE ) influence the synthesis and the secretion of apoB and apoA 1 containing lipoproteins . ^^^ The incorporation of 35S labeled amino acids into cell and medium apoB and apoA 1 was measured in liver slices . ^^^ The increased secretion of apoB and apoA 1 in CH F chicks was associated with an increased secretion of very low , intermediate , and low density lipoproteins containing newly synthesized apoB and apoA 1 and of high density lipoproteins containing predominantly apoA 1 . ^^^ Thus , in response to hepatic CE accumulation induced by cholesterol feeding , a larger proportion of newly synthesized apoB is driven to the secretory pathway and more apoA 1 is synthesized . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Multivariate analysis showed that no parameter involving apoC 3 and apoE was more discriminatory than HDL cholesterol , cholesterol , and triglycerides or apoA 1 , apoB , and triglycerides between controls and MI subjects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Effect of ethanol on the synthesis and secretion of apoA 1 and apoB containing lipoproteins in HepG 2 cells . ^^^ In contrast to the short term effect of ethanol , long term incubation with ethanol resulted in a dose dependent increase in the secretion of newly synthesized apoA 1 without significantly affecting that of apoB 100 . ^^^ These observations indicate that in HepG 2 cells the effect of ethanol on the production of apoA 1 and apoB containing lipoproteins is both time and dose dependent and is different in these two apolipoproteins . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Furthermore , serum cholesterol esters and the cholesterol esters / free cholesterol ( CE / FC ) ratio was higher , and the atherogenic index , i . e . ( apoB 10 ( total cholesterol HDLc ) / apoA 1 10 HDLc , lower in persons with high HDL . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There was a relationship between the highest recorded activity and apoAI ( P < or = 0 . 01 ) and apoB ( P < or = 0 . 01 ) in males and with apoB ( P < or = 0 . 001 ) in females ; between habitual activity and apoAI ( P < or = 0 . 01 ) and apoAII ( P < or = 0 . 05 ) in males and apoB ( P < or = 0 . 01 ) in females ; between past activity and Lp ( a ) in females ( P < or = 0 . 05 ) . ^^^ An association between highest recorded activity and apoAI ( P < or = 0 . 01 ) , and past activity and apoAI : apoB ratio ( P < or = 0 . 05 ) was shown in males and in females , after adjustment , and between apoB ( P < or = 0 . 05 ) and highest recorded activity . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
SDS gel analysis revealed an absence of apoB 48 , an increase in apoB 100 in the very low density lipoprotein ( VLDL ) and low density lipoprotein ( LDL ) fractions , and a small decrease in apoA 1 in the HDL fractions in the apobec 1 ( / ) samples . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RNA solution hybridization assay indicated that CP 10447 did not affect apoB or apoA 1 mRNA levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ratios of LDL cholesterol / HDL cholesterol and apoB / apoA 1 in the early follicular phase were greater by 5 . 6 % and 6 . 0 % , respectively , than those in the midluteal phase . ^^^ Fluctuations in total cholesterol , triglyceride , apoA 1 , and apoB did not reach significance . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Clathrin coated vesicle purification following HDL 3 or LDL internalization at 37 degrees C showed radioactivity associated with these vesicles , and further content analysis evidenced the presence of radiolabeled apoA 1 and apoB , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In the present work we investigated HDL C and its subfractions HDL 2 and HDL 3 as well as total cholesterol ( TC ) , triglycerides ( TG ) , LDL C , VLDL C , apolipoproteins A 1 ( ApoA 1 ) and B ( ApoB ) and lipoprotein ( a ) ( Lp ( a ) in 25 patients with newly diagnosed acute lymphocytic leukemia ( ALL ) before and after induction treatment . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have examined the impact of APOE polymorphism on quantitative risk factors for CAD ( apoAI , apoB , TC , LDL C , HDL C and TG ) in a sample of 647 African American and 573 White 9 10 year old girls who were enrolled in the National Heart , Lung and Blood Institute Growth and Healthy Study . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Between 7 and 13 months of age , the serum cholesterol concentration in infants in the intervention group was unchanged , apoB concentration increased slightly , and apoA 1 concentration decreased . ^^^ In the control infants , serum cholesterol concentration increased 9 + / 25 mg / dL ( 0 . 24 + / 0 . 65 mmol / L ) , apoB concentration increased markedly , and apoA 1 concentration was stable . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Immunostaining showed significant apoE and apoA 1 , but very little apoB in the peripheral cornea . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Our data indicate that women have significantly higher values of HDL C , apoA 1 , apoE , and Lp A 1 ; larger LDL and HDL particle sizes ; and lower values of triglyceride , apoB , and Lp B : C 3 particles than men , with no difference in Lp A 1 : A 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Blood pressure , heart rate , TC , HDL C ( HDL 2 C , HDL 3 C ) , apoA 1 , apoB , TG were measured at the 4th , 8th , 12th weeks of treatment . ^^^ In Group B fluvastatin significantly reduced the level of TC ( from 7 . 22 + / 0 . 88 to 5 . 99 + / 0 . 98 mM / L ) , of LDL C ( from 5 . 13 + / 0 . 71 to 3 . 95 + / 0 . 88 mM / L ) , and the level of ApoB ( from 0 . 97 + / 0 . 26 to 0 . 85 + / 0 . 15 mM / L ) , but did not influence significantly the level of HDL C , ApoA 1 and TG . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The lipid data showed a mixed hyperlipidemia with predominant hypertriglyceridemia , low HDL C , apoA 1 and LpA I / A 2 , and high apoB as compared with controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : As expected , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein B ( ApoB ) , apolipoprotein A 1 ( ApoA 1 ) and triglycerides increased linearly with the level of total cholesterol in all race sex subgroups . ^^^ The LDL C / HDL C , ApoB / ApoA 1 and LDL C / ApoB ratio also increased with total cholesterol in all race sex subgroups . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Treatment of these cells with the MTP photoaffinity inhibitor BMS 192951 before pulse labeling with [ 35S ] methionine / cysteine led to an 85 % block of both apoB 48 and apoB 100 but not apoAI secretion , demonstrating inhibition of the first step of lipoprotein assembly . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Overweight boys had significantly higher levels of total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , atherogenic index ( AI ) , RLP cholesterol ( RLP C ) , apoA 1 , apoA 2 , apoB , apoC 2 , apoC 3 , apoE and the ratio of apoB to apoA 1 than non overweight boys . ^^^ Overweight girls had significantly higher levels of TC , LDL C , AI , remnant like lopoprotein cholesterol ( RLP C ) , apoA 2 , apoB , apoC 2 , apoC 3 , apoE and the ratio of apoB to apoA 1 than non overweight girls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apoC 3 enhancer can also restore the activity of the proximal apoA 1 and apoB promoters that have been inactivated by mutations in CCAAT / enhancers binding protein binding sites , indicating that C / EBP may not participate in the synergistic activation of the promoter / enhancer cluster . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol , low density lipoprotein ( LDL ) , high density lipoprotein ( HDL ) , triglycerides , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) , and lipoprotein ( a ) ( Lp [ a ] ) were measured in a group of 160 middle aged parents and their twin offspring ( first project ) and in a group of 203 middle aged twin pairs ( second project ) . ^^^ For ApoA 1 , ApoB , and Lp ( a ) , the same genes seem to act in both generations . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In hypercholesterolaemic SHRSP fed a high fat and high cholesterol diet ( HFC diet ) , only episesamin improved serum lipoprotein metabolism with an increase in apoA 1 and a decrease in apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Freeze substitution and low temperature embedding in Lowicryl K4M , in contrast , appeared to better preserve the lipid and lipoprotein structures ; however , the antigenicity of both apoAI and apoB appeared to be lost and no specific labeling could be obtained . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma total cholesterol ( 6 % , P = . 04 ) , LDL cholesterol ( 16 % , P = . 0001 ) , and apoB ( 11 % , P = . 001 ) levels decreased and HDL cholesterol ( 20 % , P = . 0001 ) and apoA 1 ( 14 % , P = . 0001 ) levels increased after ERT compared with placebo . ^^^ We conclude that plasma levels of HDL cholesterol , apoA 1 , LDL cholesterol , apoB , and glycated hemoglobin are improved in postmenopausal women with type 2 diabetes mellitus after treatment with 17 beta estradiol , indicative of a better metabolic control , and that ERT has no effect on LDL oxidizability . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In stepwise multiple regression analysis in 184 nonsmokers , apoE , apoB and fat mass explained 21 % of apoAI variability . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Low density lipoprotein cholesterol , apolipoprotein B ( apoB ) , high density lipoprotein cholesterol , and apoA 1 concentrations all decreased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We examined common polymorphisms in the genes encoding the LDL receptor , lipoprotein lipase , apoAI , apoB , apoAIV and cholesteryl ester transfer protein and related them to changes in LDL and HDL cholesterol after high fat / high cholesterol diets . 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We demonstrated that exposure of HepG 2 cells to gramoxone ( 0 . 1 microM ) resulted in a 2 fold decrease in apoA 1 mRNA with no significant change in apoB and apoE mRNA levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Genotypic effects of the two polymorphisms on fasting serum triglycerides ( TG ) , total cholesterol ( Tchol ) , high density lipoprotein cholesterol ( HDLc ) , low density lipoprotein cholesterol ( LDLc ) , apoB , apoA 1 , and apoE levels were studied separately for each polymorphism and in conjunction . epsilon 4 allele and high apoE levels were associated with high levels of LDLc , Tchol , apoB , and TG . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Despite the prevalence of allele 4 of apolipoprotein E genotype in group A patients , their levels of serum total cholesterol , low density lipoprotein cholesterol , lipoprotein ( a ) [ Lp ( a ) ] , apolipoprotein B ( ApoB ) , and apolipoprotein A 1 ( ApoA 1 ) were significantly lower than those of patients with preserved RRF ( group B ) . ^^^ Serum concentrations of Lp ( a ) and ApoA 1 , as well as ratios of ApoA 1 to ApoB , were correlated significantly with RRF ( r = 0 . 63 , r = 0 . 51 , and r = 0 . 61 , respectively ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In addition , in a subgroup of individuals with a higher risk of MI by either high apoB and / or low apoA 1 plasma levels the portion of MI patients was clearly smaller within H2H2 homozygotes than within H1H2 or H1H1 genotypes , although also in these high risk groups mean age at first MI of H2H2 individuals were higher than of the other two genotypes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We studied the kinetic aspects of apoB and apoAI containing lipoprotein metabolism in two sisters with analbuminemia using a constant 14 hour infusion of leucine labeled with stable isotopes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Since inbred strains of mice differ in their genetic background and show differing responsiveness to dietary lipids , we examined how various inbred strains of mice respond to estradiol administration , and whether some mouse strains show responses similar to rats . 17beta estradiol was administered to male mice from 15 different inbred strains , and the changes in plasma levels of lipids , apoB , apoAI , and apoE were examined . ^^^ Total cholesterol decreased in all but one strain , apoAI levels decreased in all but 3 strains while apoB levels and apoB / apoAI ratios increased in all but 2 strains , suggesting that in contrast to rats , the apoB containing lipoproteins increased relative to HDL in all strains of mice examined . ^^^ Basal and estradiol induced changes in total cholesterol were significantly correlated with changes in apoAI , but not apoB , reflecting the predominance of HDL over other lipoproteins in mouse plasma . ^^^ Similarly , most of the mouse strains did not show correlation of plasma apoAI and apoB levels with the corresponding hepatic mRNA levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Among women , GH correlated positively with the use of hormonal contraception , HDL cholesterol , apoA 1 , and apoA 2 , and negatively with BMI , age , menopause , triglycerides , and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The patients did not differ from the controls for plasma total cholesterol ( TC ) , HDL cholesterol , LDL cholesterol , and apoAI values , while they presented significantly higher levels of triglycerides and apoB , and lower apoE levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma levels of total cholesterol ( TC ) , triglyceride ( TG ) , high density lipoprotein ( HDL ) C , apoAI , apoB , apoCII , apoCIII , and apoE were 200mg / dL , 451 mg / dL , 31 mg / dL , 115 mg / dL , 99 mg / dL , 10 . 0 mg / dL , 22 . 2 mg / dL , and 12 . 0 mg / dL , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
From the solution of the integrated compartmental models , residence times of the radiation in various source organs , in particular the thyroid , whole body , bladder , and red bone marrow , have been determined for the apolipoproteins apoA 1 , apoA 2 , very low density lipoprotein ( VLDL ) apoB , and low density lipoprotein ( LDL ) apoB , each labeled with iodine 123 , 133 , 124 , 131 , 126 , and 125 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The MCFA diet significantly decreased the apoA 1 to apoB ratio compared with both other diets ( P < 0 . 02 ) . ^^^ We conclude that MCFA raise LDL cholesterol concentrations slightly and affect the apoA 1 to apoB ratio unfavorably compared with oleic acid . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
While atorvastatin also resulted in clinically significant reductions in triglyceride , VLDL cholesterol , apoB in VLDL , triglyceride in VLDL , and apoC 3 and significant increases in HDL cholesterol and apoA 1 levels , fenofibrate was more effective than atorvastatin in altering all these parameters . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Apolipoprotein B ( apoB ) and LDL cholesterol levels decreased by 7 % ( P = . 01 ) and 12 % ( P = . 03 ) , respectively , ApoB , LDL cholesterol , and Lp ( a ) levels fell within 1 week of treatment , whereas apoA 1 and HDL cholesterol levels rose more slowly . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Total plasma cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , triglycerides , apolipoprotein A 1 ( ApoA 1 ) , and apolipoprotein B ( ApoB ) concentrations were determined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Quantification of rabbit plasma apoA 1 was not affected when sheep anti rabbit apoA 1 serum was mixed with sheep anti rabbit apoB or apoE serum ; thus , the antibody need not be specific to quantify the ligand of interest . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lower levels of plasma apolipoprotein ( apo ) A 1 and higher levels of apoB , lipoprotein ( a ) ( Lp ( a ) ) , and the ratio of apoB to apoA 1 are considered to be independent risk factors for coronary heart disease . ^^^ To examine race differences in the distributions of plasma levels of apoA 1 , apoB , and Lp ( a ) , the authors have determined quantitative levels of these traits in 252 nondiabetic Hispanics and 459 nondiabetic non Hispanic whites ( NHWs ) from the San Luis Valley , Colorado . ^^^ Hispanic men and women , respectively , had significantly higher plasma apoB levels ( p < 0 . 003 ; p < 0 . 01 ) and the ratio of apoB to apoA 1 ( p < 0 . 003 ; p < 0 . 0003 ) than their NHW counterparts . ^^^ Overall , the threshold points of apoA 1 ( < 120 mg / dl ) , apoB ( > 120 mg / dl ) , and Lp ( a ) ( > 25 mg / dl ) were higher in Hispanics than in NHWs for apoA 1 ( 22 . 8 vs . 15 . 7 % ) , apoB ( 16 . 9 vs . 9 . 9 % ) , and Lp ( a ) ( 18 . 6 vs . 12 . 4 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The purpose of this experiment was to investigate the effects of breeder flock age ( 30 vs . 39 weeks ) and sex of the newly hatched chicks on lipoprotein composition and apolipoprotein AI ( apoAI ) and B ( apoB ) concentrations . ^^^ Serum apoAI and apoB were compared by density scanning of VLDL , IDL , LDL and HDL fractions from sequential ultracentrifugation spins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cholesterol , HDL , LDL , apolipoprotein A ( ApoA 1 ) and B ( ApoB ) , triglycerides , lipoprotein ( a ) ( Lp ( a ) ) , and fibrinogen were measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Multiple linear regression analysis , when adjusted for sex , age , and BMI , showed that three lipid variables ( TRL apoB , LDL cholesterol , and plasma apoA 1 ) significantly and independently predicted the coronary score . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipid profile including total cholesterol , triacylglycerol , HDL cholesterol , LDL cholesterol , lipoprotein ( a ) , apoAI and apoB , and acute phase reactants including polymorphonuclear ( PMN ) elastase , PMN leukocyte count , erythrocyte sedimentation rate ( ESR ) and complements ( C 3 , C 4 ) were evaluated in patients in active and inactive periods of Behet ' s disease and control subjects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In 50 admitted patients with essential hypertension and family history of risk , high levels of apoA 1 and apoB were recorded although cholesterol and other biological markers were within the normal . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum total cholesterol ( CHOL ) , triglycerides ( TG ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein A 1 and B ( ApoA 1 and ApoB ) were measured by standard methods , low density lipoprotein cholesterol ( LDL C ) and CHOL / HDL C ratio were calculated by formula . ^^^ After adjusting for age , girls had higher total CHOL , TG , HDL C , LDL C , ApoA 1 and ApoB concentrations than boys . ^^^ Among girls , we found WHR and BMI to be the strongest positive predictors of TG and ApoB level respectively ( both P < 0 . 001 ) , but skinfold measurements were best for predicting HDL C , LDL C , ApoA 1 and the CHOL / HDL C ratio . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma levels of LCAT , cholesterol , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol ( HDL C ) , triglycerides , apoB , and apoAI were evaluated before and after 1 and 3 months of therapy . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice . ^^^ To study the role of low levels of high density lipoprotein ( HDL ) and apolipoprotein ( apo ) A 1 in atherosclerosis risk , human apoB transgenic mice ( HuBTg ) were crossed with apoA 1 deficient ( apoA 1 / ) mice . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
These mutations result in hypercholesterolemia due to the presence of large cholesteryl ester rich HDL particles , elevated plasma apoA 1 and apoE , and reduced apoB levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have searched for possible `` level gene ' ' or `` variability gene ' ' effects of ACE genes on Lp ( a ) lipoprotein , total cholesterol ( TC ) , high density lipoprotein ( HDL ) cholesterol ( HDLC ) , low density lipoprotein ( LDL ) cholesterol ( LDLC ) , triglycerides ( TG ) , apolipoprotein B ( apoB ) , apolipoprotein A 1 ( apoA 1 ) , and body mass index ( BMI ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Secretion of apoB and apoA 1 containing lipoproteins by chick kidney . ^^^ Aims of the present study were : a ) to compare apoB and apoA 1 production in chick kidney and liver ; b ) to investigate whether kidney apolipoproteins were secreted as constituents of lipoproteins ; and c ) to define the cellular sites of renal apolipoprotein synthesis . ^^^ Kidney and liver slices taken from the same animals were incubated with 35S labeled amino acids and radioactive apoB and apoA 1 were immunoprecipitated from cell homogenate and incubation medium . ^^^ The percentage of total protein radioactivity incorporated into cell plus medium apoB and apoA 1 was 0 . 23+ / 0 . 08 and 0 . 19+ / 0 . 11 in kidney and 0 . 38+ / 0 . 05 and 0 . 38+ / 0 . 07 in liver , respectively ( P < 0 . 05 kidney vs . liver ) . 35S labeled medium lipoproteins were separated by density gradient ultracentrifugation and three major classes corresponding to VLDL + IDL , LDL , and HDL were identified . ^^^ Immunohistochemical analysis of kidney sections showed that apoB and apoA 1 were present almost exclusively in the epithelial cells of proximal and distal convoluted tubules . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum cholesterol , triglycerides , HDL cholesterol ( HDL C ) , LDL cholesterol ( LDL C ) , apoA 1 and apoB were measured before and at the end of the supplementation period . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
When group 1 and group 2 patients were compared , group 1 was found to have higher serum cholesterol , triglycerides , apoB and Lp ( a ) as well as lower HDL and apoAI . ^^^ Lp ( a ) , LDL , total cholesterol , triglycerides . apoB , HDL and apoAI were significantly related to the number of major coronary arteries with > 50 % stenosis . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Family history score ( FHS ) for HL was related to serum total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDLC ) , high density lipoprotein cholesterol , apolipoprotein A 1 , apolipoprotein B ( apoB ) and lipoprotein ( a ) in elementary students , and to TC , LDLC , triglyceride and apoB in junior students . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum levels of low density lipoprotein cholesterol ( LDLC ) ( P = 0 . 013 ) , triglycerides ( TG ) ( P = 0 . 0006 ) , and apolipoprotein B ( apoB ) ( P = 0 . 003 ) , and the apoB / A 1 ratio ( P = 0 . 005 ) were significantly higher and serum levels of high density lipoprotein cholesterol ( HDLC ) ( P = 0 . 00003 ) and apoA 1 ( P = 0 . 003 ) were significantly lower in obese boys than in non obese boys . ^^^ In boys , atherogenic lipoproteins and apolipoproteins , such as LDLC and apoB , showed a stronger correlation with the thickness of the triceps skinfold , while in girls the anti atherogenic lipoproteins and apolipoproteins , such as HDLC and apoA 1 , showed a stronger correlation with both the triceps and the subscapular skinfold thicknesses . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
No other consistent associations were found between insulin dose and other cardiovascular risk factors : body mass index , central adiposity , arterial blood pressures , serum total cholesterol , apoA 1 , apoB , Lp ( a ) , uric acid , or urinary albumin excretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
CONCLUSION : These findings indicate that thyroid hormone influences the transport not only of both TG rich and cholesterol rich apoB containing lipoprotein particles but also of those that contain apoAI . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fasting plasma concentrations of apoB , apoA 1 , cholesterol ( chol ) , low density lipoprotein cholesterol ( LDL chol ) , high density lipoprotein cholesterol ( HDL chol ) , and triglycerides ( TGs ) were determined . ^^^ In conclusion , apoB was superior to chol , LDL chol , HDL chol , TG , and apoA 1 in discriminating between CAD+ and CAD . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The presence of apoA 1 , apoB and apoE immunoreactivity in liver cell nuclei was demonstrated by immunochemical methods ( ELISA and dot immunoassay ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Measurement of apoB concentration in the media showed that apoB secretion was reduced in proportion to the in situ inhibition of MTP activity , while no change was observed in apoA 1 secretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
On a ligand blot , HL bound to apoB 26 , 48 , and 100 but not to apoE or apoAI . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Genes shown to affect risk factors or protective factors with respect to coronary heart disease ( CHD ) have been identified at the APOB , APOAI , LPA , LDLR , APOE and CETP loci . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In multiple linear regression models adjusting for age , center , sex , and diabetes , the diabetes by sex interaction terms were statistically significant for waist to hip ratio , LDL cholesterol , HDL cholesterol , apoB , apoA 1 , fibrinogen , and LDL size . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : The spatial relationships of versican , biglycan , and apoE were compared on 68 human coronary artery segments ; apoA 1 and apoB also were evaluated on an additional 20 segments . ^^^ Nonatherosclerotic intima contained extensive deposits of versican , whereas deposits of apoE , apoB , and apoA 1 were much less prevalent . ^^^ In contrast , nearly all atherosclerotic segments contained substantial deposits of biglycan , apoE , apoA 1 , and apoB . ^^^ ApoA 1 , the major apolipoprotein of HDL , and apoB also were detected in regions with apoE and biglycan deposition . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
A family was identified with vertical transmission through three generations with simultaneous increases of apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , low density lipoprotein ( LDL ) cholesterol , and high density lipoprotein ( HDL ) cholesterol , which we have designated familial hyperalphalipoproteinemia and hyperbetalipoproteinemia ( HA / HBL ) . ^^^ HA / HBL apoA 1 and LDL apoB were isolated and characterized . ^^^ The in vivo kinetics of radiolabeled apoA 1 and LDL apoB were evaluated in two HA / HBL probands and three controls . ^^^ Structural and metabolic characterization showed normal apoA 1 and LDL apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum levels of triglyceride and apo AI did not differ according to apoE genotypes , whereas serum level of apoB was significantly different according to apoE genotypes ( p < 0 . 05 ) both in healthy and coronary artery disease groups . ^^^ ApoE concentration was positively correlated with cholesterol , apoAI , and apoB levels in the control subjects and no significant correlation was observed with triglyceride level . ^^^ In the control group , apoE genotypes and apoE level explained together 19 . 3 % and 26 . 6 % of the variability of apoB and cholesterol level , respectively , apoE polymorphism explained 23 % of the variability of apoE level and apoE level explained 13 . 2 % of the variability of apoAI level . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Patients with DN had a plasma lipid and apolipoprotein profile characteristic of renal dyslipoproteinaemia with increased concentrations of triglycerides and cholesterol , reduced levels of apoA 1 and apoA 2 and increased levels of apoB , apoC 2 , apoC 3 and apoE . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
On a chow diet SR BI transgenic ( SR BI Tg ) mice have decreased HDL CE , apoA 1 , and apoA 2 levels ; plasma triglycerides , low density lipoprotein ( LDL ) cholesterol , and very low density lipoprotein ( VLDL ) and LDL apoB were also decreased , compared with control mice . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : In the whole group , mean values of Lp ( a ) , total cholesterol , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein B ( apoB ) and very low density lipoprotein cholesterol ( VLDL C ) were higher ( P < 0 . 05 0 . 001 ) and apoA 1 was lower ( P < 0 . 05 ) in cases than in controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
With cilostazol , there was a trend ( 3 % ) toward decreased apoB as well as increased apoA 1 , resulting in a significant ( 9 . 8 % , P < 0 . 002 ) increase in the apoA 1 to apoB ratio . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ratio apoB : apoA 1 was 10 . 4 % higher in subjects on the PHFO diet than on the VO diet ( P < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The lipid profile included measurement of serum triglyceride , cholesterol , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein A 1 ( apoA 1 ) , and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In multiple regression analysis , apoB , triglyceride , HDL cholesterol , apoAI and percent body fat explained 18 % of LDLPPD variability . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However , there was significant evidence ( P < 0 . 10 ) that associations between variation in the probability of having CAC and variation in body mass index , plasma total cholesterol , and plasma ApoB in men and body mass index , plasma triglycerides , plasma ApoA 1 , and plasma ApoE in women were dependent on ApoE genotype . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To date , transgenes for human apo ( a ) , apoA 1 , apoB , apoE 2 , apoE 3 , HL , and lecithin : cholesterol acyltransferase ( LCAT ) , as well as for rabbit apolipoprotein B mRNA editing enzyme catalytic poly peptide 1 ( APOBEC 1 ) , have been expressed in NZW rabbits , whereas only those for human apoA 1 and LCAT have been introduced into the WHHL background . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Changes in total plasma cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , triglycerides ( TG ) , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) concentrations , the ratios TC / HDL C , LDL C / HDL C , ApoA1 / ApoB and HDL C / ApoA1 , and physical capacity ( maximal isometric strength , sprint power output , maximal power output , aerobic power ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The lipid measures included HDL cholesterol ( HDL C ) and non HDL C , and the apolipoprotein measures included concentrations of apoA 1 , apoB , and Lp ( a ) , and sizes of the apo ( a ) proteins . ^^^ Neither apoA 1 nor apoB measures were as strongly or consistently correlated with extent of lesions as the corresponding lipid measure ( HDL C and non HDL C , respectively ) . ^^^ Beyond the basic model that included sex , age , race , smoking status , hypertension , and the lipid measures , apoA 1 and apoB added only an average 1 . 3 % increased explanatory ability to the model , whereas HDL C plus non HDL C added an average 2 . 5 % . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In glomerular lesions , although there was an abundance of apoB and apoE , oil red O positive lipids , macrophages , apoA 1 , and malondialdehyde were scarce . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Other loci , including APOA 4 , APOA 1 and APOB have also been found to account for some of the variability in the fasting and fed states . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum cholesterol , LDL ch , apolipoprotein B ( apoB ) , and apoA 1 levels increased during the diet period with GH therapy and tended to increase during the diet period without GH . ^^^ However , GH therapy did not influence the dietary effect on serum cholesterol , LDL ch , apoA 1 , or apoB levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoB is absent in urine of healthy subjects , and apoA 1 is determined in trace quantity . ^^^ The ELISA method for determining apoA 1 and apoB in urine makes it possible to evaluate the gravity of pathological process in kidney . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
While there were no differences in triglycerides and apolipoprotein B ( apoB ) values between patients and controls , apolipoprotein A 1 ( apoA 1 ) and HDL C levels were higher in the IDA group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoE4Freiburg affects serum lipoproteins by lowering cholesterol , apoB , and apoA 1 compared with apoE 4 ( P < 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
High levels of D dimer ( hazard ratio , 2 . 43 ; 95 % CI , 1 . 49 , 3 . 97 ) and apoB ( hazard ratio , 1 . 82 ; 95 % CI , 1 . 10 , 3 . 00 ) and low levels of apoA 1 ( hazard ratio , 1 . 84 ; 95 % CI , 1 . 10 , 3 . 08 ) were independently associated with recurrent coronary events in the Cox model after adjustment for 6 relevant clinical covariates . ^^^ CONCLUSIONS : Our findings indicate that a procoagulant state , as reflected in elevated levels of D dimer , and disordered lipid transport , as indicated by low apoA 1 and high apoB levels , contribute independently to recurrent coronary events in postinfarction patients . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma levels of total cholesterol ( T CHOL ) , triglyceride ( TG ) , beta lipoprotein ( beta LIPO ) , free fatty acid , phospholipid , free cholesterol , high density lipoprotein cholesterol , lipoprotein ( a ) [ Lp ( a ) ] , lipoproteins ( VLDL , LDL , HDL ) and apolipoproteins ( apoAI , apoAII , apoB , apoCII , apoCIII , apoE ) were determined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Other loci , including APOA 4 , APOA 1 , APOB , APOC 3 , LPL and CETP have also been found to account for some of the variability in the fasting and fed states . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Association of waist circumference with ApoB to ApoAI ratio in black and white Americans . ^^^ Central adiposity , acting through many CVD risk factors , including , plasma glucose , insulin , total cholesterol , low density lipoprotein cholesterol ( LDL C ) and lipoprotein moities apolipoprotein B ( ApoB ) , apolipoprotein A 1 ( ApoAI ) , by atherogenic and thrombotic mechanisms has been proposed as a possible mechanism . ^^^ In this study , we examined the relationship between central fat distribution ( defined by waist circumference ) and the ratio of these lipoproteins ( ApoB / ApoAI ) . ^^^ SUBJECTS AND METHODS : Association between ApoB / ApoAI ratio and waist circumference was compared in Blacks ( n = 854 ) and Whites ( n = 2552 ) using the NHANES 3 population based samples . ^^^ Correlation analyses and multiple regression analyses were used to determine the association between ApoB / ApoAI and waist circumference , controlling for age , body mass index ( BMI ) , race , gender , plasma glucose , insulin , serum triglyceride and total cholesterol . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Unlike the case of albumin or transferrin , or apoA 1 in the rat , LDL apoB 100 synthesis is not related to that of albumin , suggesting a different mechanism of regulation or a response to a stimulus that is not the same as that augmenting the synthesis of nonlipoproteins . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Significant correlations were also observed between levels of MDA , apoB / apoA 1 , apoE / apoC 3 , and Ccr and age , as well as between apoE levels and UP and age . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In children , soluble VCAM 1 levels were correlated with the levels of triglyceride ( in boys ) and apoB , the ratio of apoB to apoA 1 and FER ( HDL ) ( in girls ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Blood spot samples ( 9 , 673 ) were subjected to immunoturbidimetric assay to determine the levels of apolipoprotein B ( apoB ) , an index of plasma low density lipoprotein , and of apolipoprotein A 1 ( apoA 1 ) , an index of plasma high density lipoprotein . ^^^ Infants with raised apoB or a reduced apoA 1 / apoB ratio were recalled , retested and , if appropriate , referred to the Vascular Risk Clinic at King ' s College Hospital for medical management . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Patients were separated into groups , 231 males ( 78 B1B1 , 108 B1B2 , 45 B2B2 ) and 175 females ( 48 B1B1 , 94 B1B2 , 33 B2B2 ) , and compared on the basis of their lipid parameters ( total cholesterol , triglycerides , high density lipoprotein cholesterol ( HDL C ) , ApoA 1 ApoB , and low density lipoprotein cholesterol ) , their micro and macrovascular complications . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
This is particularly true for the effects on apoB and apoA 1 which were found to be synergistically depressed and enhanced , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Levels of total cholesterol , high density lipoproteins ( HDL ) , apolipoproteins A 1 and B ( ApoA 1 and ApoB ) , fibrinogen ( Fb ) and Lp ( a ) were measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The data of this work concern the hematochemical parameters : CT , HDL CT , LDL CT , TG , ApoA 1 , ApoB , fibrinogen , GOT , GPT , CPK , glucose , uric acid . ^^^ ApoA 1 , ApoB , fibrinogen by immunoturbidimetric methods . ^^^ Females showed higher mean values than males of these parameters : CT , LDL CT , HDL CT , ApoA 1 , ApoB , fibrinogen , CPK . 55 % of females had LDL CT > 159 mg / dl , values considered high risk for cardiovascular diseases . 36 % of males presented HDL CT < 40 mg / dl , with 2 cases < 25 mg / dl . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Serum cholesterol , very low density lipoprotein ( VLDL ) cholesterol , triglycerides , VLDL triglycerides , high density lipoprotein ( HDL ) and low density lipoprotein ( LDL ) triglycerides , apolipoprotein B ( ApoB ) and atherogenic ratios of cholesterol : HDL cholesterol , LDL cholesterol : HDL cholesterol and ApoB : apolipoprotein A 1 ( ApoA 1 ) were significantly increased in lipodystrophy positive compared with lipodystrophy negative men . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Baseline LDL C , HDL C , and apoB were significant predictors of AMCE ; only on treatment apoB and the ratio of apoB to apoAI were predictive of subsequent risk ; on treatment LDL C was not . ^^^ On treatment apoB , especially when combined with apoAI to form the apoB / AI ratio , may be a more accurate predictor than LDL C of risk for first AMCE . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In postobese patients , intraperitoneal PPARgamma expression was associated with plasma HDL cholesterol ( r=0 . 5695 , P < 0 . 018 ) and apoA 1 ( r=0 . 6216 , P < 0 . 008 ) but was inversely related to LDL cholesterol ( r= 0 . 5101 , P < 0 . 03 ) and apoB ( r= 0 . 6331 , P < 0 . 007 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The estimation of serum biochemical components included serum 17 beta estradiol ( E 2 ) , testosterone ( T ) , total cholesterol ( TC ) , triglyceride ( TC ) , high density lipoprotein cholesterol ( HDL C ) , low density protein cholesterol ( LDL C ) , apolipoprotein A 1 ( ApoAI ) , apolipoprotein B ( ApoB ) , lipoprotein ( a ) [ Lp ( a ) ] , immunoglobulin G ( IgG ) , and IgG antibody against cardiolipin ( ACAIgG ) . ^^^ In postmenopausal women , serum levels of E 2 , E2 / T , HDL , and ApoAI decreased , while those of T , TC , TG , LDL , ApoB , Lp ( a ) , IgG , and ACAIgG increased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The results demonstrated that owing to the intake of high cholestrol diet with the passage of time , the increased concentrations of serum VLDL C , apoB , apoC 2 and apoC 3 possibly caused an enhanced secretion of biliary cholesterol into bile ; that the decreased serum apoA 1 level might reduce the secretion of anti nucleating factor into bile . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There was no cross reactions between antibodies used and apoAI , apoAII , apoB , apoCI , apoCII and apoCIII . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In the short term study , current users had a significant increase in serum HDL cholesterol , apolipoprotein A 1 , A 2 and a decrease in total / HDL cholesterol ratio , apoB and antithrombin 3 ( p < 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoB synthesis measured on isolated hepatocytes decreased in B 100 / B 81 mice by 35 % , while apoB 48 , apoE , and apoAI syntheses remained unchanged . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : In CR 1 A and CR 1 B dyslipoproteinemia was found at different stages of renal insufficiency which was manifested by the significant increase of TG , TC , LDL C , apo B levels and TC / HDL C , LDL C / HDL C ratios and significant decrease of HDL C level and apo AI / apoB , HDL C / apoAI ratios in comparison with controls . ^^^ We also observed decreased TG , TC , LDL C , apo AI , apo B levels and TC / HDL C , LDL C / HDL C ratios and unchanged HDL C level and apo AI / apoB , HDL C / apoAI ratios in cm c in comparison to CR 1 A . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
One year after Tx , we found a significant increase of total cholesterol ( TC ) , LDL , HDL , ApoB and ApoA 1 ( p < 0 . 005 ) , while plasma triglyceride levels remained unmodified . ^^^ Noteworthy , LDL / HDL ratio and ApoB / ApoA 1 ratio in kidney transplanted patients were almost superimposable with those of normal controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We used standard methods to measure serum total cholesterol ( CHOL ) , triglycerides ( TG ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein A 1 and B ( ApoA 1 and ApoB ) and Lp ( a ) levels . ^^^ After adjusting for age , cigarette smoking , alcohol drinking , puberty development and heart rates , LDL C and ApoB levels were significantly positively associated with Lp ( a ) levels while ApoA 1 was negatively associated among boys . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In vivo metabolism of ApoB , ApoA 1 , and VLDL triglycerides in a form of hypobetalipoproteinemia not linked to the ApoB gene . ^^^ In addition to having low apoB levels , some , but not all , of the affected subjects in the F kindred also had low levels of high density lipoprotein ( HDL ) cholesterol and apoA 1 . ^^^ Therefore , we studied the in vivo kinetics of apoB and apoA 1 and very low density lipoprotein ( VLDL ) triglycerides in 4 affected subjects and 5 normolipidemic relatives . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Hepatic levels of apoA 1 mRNA in coconut oil fed animals were elevated 150 % after 4 weeks compared to chow fed controls ; hepatic mRNA levels for ten other genes either decreased slightly ( apoB , LCAT , hepatic lipase , albumin , ACAT , and HMG CoA reductase ) or were unchanged ( CETP , apoE , LDL receptor , and acyl CoA oxidase ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
LpA 1 , LpA 1 : A 2 and LpB were measured by a noncompetitive enzyme linked immunoassay using previously characterized monoclonal antibodies against ApoA 1 , ApoA 2 and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After 6 months , gemfibrozil therapy versus placebo had a marked lipid lowering effect , significantly decreased triglycerides ( 61 % ) , VLDL cholesterol ( 72 % ) , apoB ( 28 % ) , and apoE ( 55 % ) , and increased high density lipoprotein ( 44 % ) and apoA 1 ( 18 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Additionally , in a subgroup of 181 children ( 68 CBZ ; 78 VPA ; 35 PB ) apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , HDL 2 C and HDL 3 C were measured and apoA I / apoB and HDL 2 C / HDL3 C ratios were calculated . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The predialysis , HD , and CAPD patients had disturbances in the concentration of serum triglyceride ( TG ) , high density lipoprotein ( HDL ) cholesterol , apolipoprotein AI ( apoAI ) , total apoCIII , apoCIII present in the particles without apoB ( apoCIII non B ) , and Lp ( a ) and HDL cholesterol , low density lipoprotein ( LDL ) cholesterol / HDL cholesterol , HDL cholesterol / apoAI , apoAI / apoB , and apoAI / apoCIII ratios . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In both groups blood samples from the umbilical cord were taken after delivery and the whole spectrum of lipid levels were evaluated ( cholesterol CH , triglycerides TGA , high density lipoprotein HDL , low density lipoprotein LDL , Lp ( a ) lipoprotein , and apolipoproteins ApoB , ApoAI , ApoE ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However HDL triglycerides were poorly predicted , while intermediate quality results were obtained for the LDL cholesterol , plasma apoA 1 and LDL apoB variables . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Parameters studied were serum total cholesterol , LDL cholesterol , HDL cholesterol , free cholesterol , phospholipids , triglycerides , apoA 1 and apoB and the fatty acid composition of serum triglycerides , free fatty acids , phospholipids and cholesterol esters . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have undertaken a study of the effect of the lipid lowering drug simvastatin on serum PON 1 activity ( in relation to paraoxon and arylesterase activity ) , on apoAI containing and apolipoprotein B ( apoB ) containing lipoproteins , and on lipid peroxide concentrations in 64 ( 39 women and 25 men ) unrelated FH patients . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Heterozygotes had significantly lower concentrations of serum beta ( 2 ) GPI than did those without the mutation , yet no significantly different lipid profiles , such as total cholesterol , triglyceride , HDL cholesterol , LDL cholesterol , apoA 1 , apoB and Lp ( a ) , were observed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipoprotein measures included triglycerides , high density lipoprotein ( HDL ) cholesterol , low density lipoprotein ( LDL ) cholesterol , apolipoprotein AI ( apoAI ) , and apolipoprotein B ( apoB ) . ^^^ Men had higher apoB and lower apoAI levels than did women . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cholesterol and triglycerides were determined by enzymatic methods , apoA 1 , apoB by immunoturbidimetry and Lp ( a ) by immunonephelemetry . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cytokines also influenced the secretion of the acute phase proteins serum amyloid A , apoA 1 , and apoB from both surfaces of Caco 2 cells . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Levels of Lp ( a ) , total cholesterol ( TC ) , triglycerides ( TG ) , low density lipoprotein cholesterol ( LDLc ) , high density lipoprotein cholesterol ( HDLc ) , apolipoprotein A 1 ( apoA 1 ) and apolipoprotein B ( apoB ) were measured before and 4 months after the achievement of euthyroidism . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Variation in apolipoprotein ( apo ) E genotypes predicts variation in plasma cholesterol and apoB ; however , the context dependent associations between high density lipoprotein ( HDL ) cholesterol , apoA 1 , triglycerides , and lipoprotein [ a ] ( Lp [ a ] ) and this polymorphism remain unsettled . ^^^ Variations in apoE genotype ( in the order listed above ) predicted stepwise increases in cholesterol and apoB in both genders ( all ANOVAs : P < 0 . 001 ) , and stepwise decreases in HDL cholesterol and apoA 1 in women ( both ANOVAs : P < 0 . 001 ) , but not in men . ^^^ Whereas the associations between variation in plasma cholesterol and apoB and the variation in apoE genotypes seem invariant , the associations with variation in plasma HDL cholesterol , apoA 1 , nonfasting triglycerides , and Lp [ a ] seem context dependent . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We analyzed the predictive value of on treatment levels of TC , LDL C , triglycerides ( TG ) , apolipoprotein A 1 ( apoA 1 ) and apolipoprotein B ( apoB ) on subsequent myocardial infarction ( MI ) and all cause mortality . ^^^ Multivariate analysis showed that on treatment apoA 1 and apoB were the only significant predictors for future cardiovascular events . ^^^ However , on treatment levels of apoB and in particular apoA 1 ( and HDL C in women ) were significantly predictive for MI and all cause mortality and may therefore be more suitable for cardiovascular risk assessment in this population . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In the present study , the effects of taxifolin , a plant flavonoid , on lipid , apolipoprotein B ( apoB ) , and apolipoprotein A 1 ( apoA 1 ) synthesis and secretion were determined in HepG 2 cells . ^^^ ApoA 1 and apoB synthesis and secretion were then studied by pulse chase experiments . ^^^ In summary , our data suggest that taxifolin decreases hepatic lipid synthesis with a concomitant decrease and increase in apoB and apoA 1 secretion , respectively . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The net accumulation in the medium of apolipoprotein A 1 ( apoA 1 ) was not significantly altered by fatty acids , whereas that of apoB was increased with oleic and elaidic acids . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : We measured concentrations of apoE , the major constituents of HDL ( cholesterol , apoAI ) , LDL C ( cholesterol and apoB ) , and fraction of apoE in lipoprotein size classes in 859 participants of the San Antonio Family Heart Study , and then tested the association between the three common apoE genotypes ( epsilon2epsilon3 , epsilon3epsilon3 , and epsilon3epsilon4 ) and lipoprotein traits using the measured genotype approach to account for residual familial correlations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Elevated plasma levels of apolipoproteins A 1 ( apoA 1 ) and B ( apoB ) are important protective factors and risk factors , respectively , for atherosclerosis and coronary heart disease . ^^^ It is well known that both apoA 1 and apoB reveal strong familial aggregation . ^^^ We show that correlation for apoB between parent offspring pairs increased with decreasing age difference and that pairs with individuals of the same gender had more similar apoA 1 levels than individuals of different gender . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Proteins with apoA 1 , apoB , and apoE immunoreactivity may be involved in the regulation of transcriptional activity of chromatin . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
OBJECTIVE : To assess the long term effects of combined oral contraceptive pills use on the mean of serum TG , TC , HDL C , LDL C , ApoA 1 , ApoB and Lp ( a ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Genotype information included measurements at 18 diallelic loci in six coronary heart disease candidate susceptibility gene regions : APOA 1 C 3 A 4 , APOB , APOE , LDLR , LPL , and PON 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After multivariable adjustment by means of linear regression analysis , only the association between HP infection and decreased HDL cholesterol ( P=0 . 002 ) , decreased HDL cholesterol to total cholesterol ratio ( P : =0 . 005 ) , decreased apoAI ( P=0 . 02 ) , and increased apoB ( P=0 . 02 ) persisted and remained significant . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In fasting state also the blood lipid profile was determined : serum triglycerides , total cholesterol , LDL cholesterol , HDL cholesterol , apolipoprotein AI ( apoAI ) and apolipoprotein B ( apoB ) . ^^^ The offspring had significantly higher mean values of serum LDL cholesterol , and significantly lower of serum HDL cholesterol and apoAI , not disclosing significant differences in the serum levels of triglycerides , total cholesterol and apoB with the control group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In this study we examined the roles of apolipoprotein B ( apoB ) , apolipoprotein AI ( apoAI ) and lipoprotein ( a ) [ LP ( a ) ] in predicting coronary heart disease in normolipidemic patients and those with premature CAD ( age < or = 50 ) . ^^^ DESIGN AND METHODS : Serum levels of apoB , apoAI , and LP ( a ) were determined in a total of 567 Iranian patients who were candidates for coronary angiography . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma levels for triacylglycerol , total cholesterol , high density lipoprotein ( HDL ) cholesterol , low density lipoprotein cholesterol , apolipoprotein A 1 ( ApoA 1 ) , and apolipoprotein B ( ApoB ) were determined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Total Cholesterol ( TC ) , Triglycerin ( TG ) , high density lipoprotein ( HDL C ) , Apolipoprotein AI ( Apo AI ) , Apolipoprotein AII ( Apo AII ) , Apolipoprotein B ( Apo B ) , Apolipoprotein CII ( Apo CII ) , Apolipoprotein CIII ( Apo CIII ) , Lipoprotein ( a ) [ Lp ( a ) ] increased significantly ( P < 0 . 05 ) , while ApoB / AI , ApoCII / CIII decreased significantly ( P < 0 . 05 ) in conjugated estrogen group . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
None of the variant sites were associated with significant differences in cholesterol , triglyceride , apoB or apoAI levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To date , transgenes for human apo ( a ) , apoA 1 , apoB , apoE 2 , apoE 3 , hepatic lipase , lecithin : cholesterol acyltransferase ( LCAT ) , lipoprotein lipase , 15 lipoxygenase , as well as for rabbit apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 ( APOBEC 1 ) , have been expressed in rabbits . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : This study examined fasting levels of total cholesterol , LDL cholesterol , high density lipoprotein cholesterol , apolipoprotein B ( ApoB ) , apolipoprotein A 1 , and triglycerides , as well as factors known to be associated with small , dense LDL , including age , sex , obesity , hypertension , and diabetes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Hepatic and macrophage expression of hABCA 1 enhanced macrophage cholesterol efflux to apoA 1 ; increased plasma cholesterol , cholesteryl esters ( CEs ) , free cholesterol , phospholipids , HDL cholesterol , and apoA 1 and apoB levels ; and led to the accumulation of apoE rich HDL 1 . ^^^ ABCA 1 transgene expression delayed 125I apoA 1 catabolism in both liver and kidney , leading to increased plasma apoA 1 levels , but had no effect on apoB secretion after infusion of Triton WR 1339 . ^^^ These studies show that steady state overexpression of ABCA 1 in vivo ( a ) raises plasma apoB levels without altering apoB secretion and ( b ) raises plasma HDL C and apoA 1 levels , facilitating hepatic reverse cholesterol transport and biliary cholesterol excretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : ( 1 ) Yishou Tiaozhi tablet obviously lowered the levels of serum TC , TG , AI , ApoB , LP ( a ) , ox LDL , HYP , plasma Ca2+ , TXB 2 and increased the levels of serum HDL ch , ApoA 1 , ApoA1 / APoB , plasma 6 keto PGF 1 alpha ( P < 0 . 01 ) . ( 2 ) Pathomorphological examination showed that in the group A aortic intimal atherosclerotic plaque area and arterial intima thickness obviously reduced , smooth muscle cell hyperplasia and elastic fibers were not seen . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : The results showed that the level of TC , TG , HDL , LDL , apoA 1 , apoB and apoA1 / apoB were significantly different in PDS and QDBS as compared with control group ( P < 0 . 05 , P < 0 . 01 , respectively ) , while lipometabolic disorder of PDS was most serious in TCM Syndrome Differentiation of stroke . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Among the 2185 subjects examined , the mean serum value for apoA 1 was 1 . 42 + / 0 . 20 g / l , for apoA 2 was 0 . 30 + / 0 . 05 g / l , for apoB was 0 . 87 + / 0 . 18 g / l , for apoC 2 was 29 + / 13 mg / l , for apoC 3 was 75 + / 20 mg / l , and for apoE was 36 + / 9 mg / l . ^^^ Moreover , individuals with elevated serum lipoprotein ( a ) [ Lp ( a ) , > 300 mg / l ] also displayed increased serum apoB and apoC 2 levels and an increased apoB / apoA 1 ratio . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
However , in the worker group , the mean levels of TC , LDL C , apoAI , apoB and Lp ( a ) were significantly higher while the mean level of HDL C was significantly lower than that of the controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Increase of LDL cholesterol and apoB concentrations with age was stronger among the epsilon 4 carriers in women , and apolipoprotein A 1 ( apoA 1 ) concentration decreased with age in epsilon 4 male carriers . ^^^ In nonsmokers only , the APOC 3 1100C allele in women was related to lower apoB related traits concentrations , and in men to higher apoA 1 and HDL cholesterol concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : All three study groups were investigated for androgen ( total testosterone ) and lipid lipoprotein profile , including apolipoproteins , ApoA 1 and ApoB . ^^^ Retrospective analysis of the data was carried out to assess hyperandrogenism in the study group of women with PCOS as well as to investigate changes in the lipid lipoprotein profile , particularly the measures of cardiovascular risk , ApoA 1 and ApoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Kazaks men and women , respectively , had significantly higher serum levels of HDL c and ApoA 1 ( all P < 0 . 001 ) and significantly lower serum levels of TG ( men P < 0 . 01 , women P < 0 . 001 ) , Lp ( a ) ( all P < 0 . 005 ) , ApoB ( men P < 0 . 005 , women P < 0 . 001 ) and ApoB / A1 ( men P < 0 . 01 , women P < 0 . 001 ) than their Han nationality controls . ^^^ The threshold points of ApoA 1 ( < 1 . 2 g / L ) and ApoB ( > 1 . 2 g / L ) are higher in Hans than in Kazaks for ApoA 1 ( 20 . 7 vs 9 . 8 % ) and ApoB ( 18 . 6 vs 14 . 3 % ) ; the serum levels of TG , HDL c , Lp ( a ) , ApoA 1 and ApoB / A1 are all closely correlated with nationality ( P < 0 . 001 , P = 0 . 001 , and P < 0 . 05 , respectively ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The content of apoB , apoE , and apoCs in both perfusate and plasma VLDL was greater in the cp / cp rat , as was the apolipoprotein ( apo ) C , apoA 1 , and apoA 4 content of plasma HDL . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Blood samples were collected from 307 normal children aged 7 to 11 years , including 150 boys and 157 girls , and their serum lipid profile , including total cholesterol ( TC ) , triglyceride ( TG ) , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein B ( apoB ) , apoprotein A 1 ( ApoA 1 ) and lipoptoein alpha [ LP ( alpha ) ] , were detected and their ApoE Hha 1 gene polymorphism were tested by the PCR RFLP method . ^^^ The levels of TC , LDL C , ApoA 1 and ApoB were higher in boys with genotypes E4 / 3 and E3 / 3 than those with genotypes E3 / 2 and E4 / 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
CONCLUSIONS : We conclude that apoA 1 but not apoB levels may serve as an effect modifier of hypertension for the risk of stroke events . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Other parameters , including apoA 1 , apoB , Lp ( a ) , HDL C , LDL C , TG , and TC , were measured as well . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fasting plasma lipoproteins , TG , total cholesterol , lipoprotein ( a ) , apolipoprotein AI ( apoAI ) , apoB , urinary protein , plasma albumin , third component of complement ( C 3 ) , ASP , and leptin levels were measured in both groups . ^^^ Total cholesterol , TG , low and very low density lipoproteins , lipoprotein ( a ) , apoB , and urinary protein levels were increased in the patient group , whereas plasma albumin , high density lipoprotein cholesterol , and apoAI levels were decreased compared with those in the control group ( P < 0 . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were no significant changes in ApoA 1 or ApoB with HD . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Consequently , an altered distribution of enzyme activity among apolipoprotein B ( apoB ) and apolipoprotein A 1 ( apoA 1 ) containing lipoproteins is observed in hypercholesterolemic patients , resulting in a significant decrease in the ratio of the HDL associated PAF AH to the total plasma enzyme activity compared with controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To demonstrate the utility of this procedure , we measured d 3 leucine enrichment in apolipoprotein B ( apoB ) isolated from VLDL and LDL as well as apoA 1 isolated from HDL by gel electrophoresis and western blotting . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESEARCH DESIGN AND METHODS : Plasma and lipoprotein lipids , apoB and apoA 1 were measured by standardized methods . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MATERIAL AND METHODS : Thirty nine coronary patients ( male ) were examined using lipid loading test , bicycle ergometry , coronarography , and measurements of insulin , cholesterol ( CS ) , triglycerides ( TG ) , very low density lipoproteins ( VLDL ) , low density lipoproteins ( LDL ) , high density lipoprotein ( HDL ) CS , apoA 1 , and apoB . ^^^ RESULTS : Blood levels of CS , TG , VLDL , LDL , HDL CS , apoA 1 , apoB , and insulin were measured before and 3 , 6 , and 9 h after lipid loading in 39 coronary patients and 20 normal subjects . ^^^ Insulin level drastically increased after insulin loading ; increases in TG and apoB levels were the most pronounced , while the concentrations of HDL CS and apoA 1 decreased and did not normalize 6 h after lipid loading . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In this report , we characterized the distribution of proteoglycans ( versican , biglycan , and perlecan ) and apolipoproteins ( apoB , apoA 1 , and apoE ) in proximal aortic lesions of chow fed apoE / and LDLR / mice at 10 , 52 , and 73 weeks of age . ^^^ ApoA 1 and apoB were detected in early through advanced lesions in regions of proteoglycan accumulation in both strains . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After adjustment for other risk factors , i . e . systolic blood pressure , LDL cholesterol , apoB , apoA 1 and smoking , the observed relationships between ox LDL and sICAM 1 and sE selectin , respectively , remained statistically significant . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoE found in the LDL fraction of RLP resides on pre beta lipoproteins that lack apoA 1 as well as apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : We examined whether AsA intake was associated with serum lipids , apolipoprotein A 1 ( ApoA 1 ) and apolipoprotein B ( ApoB ) , in 680 Japanese elderly persons . ^^^ AsA intake had a significant positive association with serum concentrations of high density cholesterol and ApoA 1 , but an inverse association with serum concentrations of low density cholesterol and ApoB , after adjusting for age , body mass index , total energy , and macronutrients . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum lipid parameters [ high density ( HDL ) , LDL and total cholesterol , triglycerides , ApoAI , ApoB and lipoprotein ( a ) ] were measured after an overnight fast before treatment and after 3 and 12 months . ^^^ The LDL / HDL cholesterol ratio decreased similarly in the two groups , but the ApoAI / ApoB ratio , which may be a better predictor of cardiovascular events , significantly changed in the ApoE 4 negative subjects . ^^^ CONCLUSION : In postmenopausal Greek women with breast cancer , the levels of Lp ( a ) and triglycerides and the ApoAI / ApoB ratio respond more favorably to tamoxifen treatment in ApoE 4 negative than in ApoE 4 positive patients . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Neither PAF nor Lexipafant influenced the mRNA levels and the secretion of apoA 1 , apoB and apoE in HepG 2 cells , indicating that the effects of PAF or Lexipafant on the apoM production on hepatic cells are selective for apoM . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Organelle apoB and apoAI content demonstrated opposite patterns after SA and EPA incubation . ^^^ Regulation of apoAI ER to G trafficking is independent of that of apoB . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fasting triglyceride , total cholesterol , low density ( LDL ) and high density lipoprotein ( HDL ) cholesterol , free fatty acid ( FFA ) , Apolipoprotein A 1 ( ApoA 1 ) , Apolipoprotein B ( ApoB ) , glucose , insulin , c peptide , leptin , cortisol , dehydroepiandrosterone ( DHEA ) , CD 4 , CD 8 lymphocyte counts and HIV RNA load were measured . ^^^ No statistical difference in triglyceride , total cholesterol , LDL cholesterol , FFA , ApoA 1 , ApoB , glucose , insulin , C peptide , leptin , cortisol , and DHEA were observed between groups 1 , 2 and 3 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
HRT ( groups A and B ) resulted in enhanced total transfer of cholesteryl ester ( CE ) from high density lipoprotein ( HDL ) to apolipoprotein B ( apoB ) containing lipoproteins ( 56 % + / 11 . 45 % 5 50 . 82 % + / 13 . 68 % , P < . 05 ) and increased apoA 1 plasma concentration ( 171 + / 30 5 147 + / 22 mg / dL , P < . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
BACKGROUND : Apolipoprotein B ( apoB ) and apolipoprotein A 1 ( apoA 1 ) are thought to be better predictors of acute myocardial infarction than total cholesterol and LDL cholesterol . ^^^ We investigated whether apoB and apoA 1 are predictors of risk of fatal myocardial infarction . ^^^ We also aimed to establish whether apoB and apoA 1 add further information about risk of fatal myocardial infarction to that obtained with total cholesterol , triglycerides , and LDL cholesterol . ^^^ We measured concentrations of apoB , apoA 1 , total cholesterol , and triglycerides , and calculated apoB / apoA 1 ratio and concentrations of LDL cholesterol and HDL cholesterol . ^^^ The relation between death from acute myocardial infarction and initial values for apoB , apoA 1 , and the other lipids was examined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Additionally , the apoAI PstI polymorphism ( P < 0 . 05 ) , the apoB XbaI polymorphism ( P < 0 . 05 ) and apoE phenotypes ( P < 0 . 05 ) were associated with plasma cholesterol concentrations . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Thomas ' UK Adult Twin Registry and measured total cholesterol , low density lipoprotein ( LDL ) , high density lipoprotein ( HDL ) , triglycerides , lipoprotein ( a ) [ Lp ( a ) ] , apolipoprotein A 1 ( apoA 1 ) , and apolipoprotein B ( apoB ) . ^^^ In premenopausal females , total cholesterol , LDL , HDL , apoA 1 , and apoB all showed an influence of the shared environment ( 22 % to 34 % ) , which , after menopause , decreased in HDL and completely disappeared in total cholesterol , LDL , and apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Transforming growth factor beta ( TGF beta ) increased apoB secretion in both differentiated and nondifferentiated Caco 2 cells and decreased secretion in HepG 2 cells without affecting apolipoprotein A 1 secretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The results showed that the serum levels of HDL c and subfractions , ApoA 1 and TC gradually decreased in ICH during acute phase , and reduced to the lowest level on the fourteenth day , while the levels of TG and ApoB had no obvious change , the serum levels of Fg and Lp ( a ) increased to the highest level on the seventh day . ^^^ The serum levels of Lp ( a ) , ApoB and TG had no obvious change in CI during acute phase , and the serum levels of TC , HDL c and subfraction , ApoA 1 decreased , while the level of Fg increased in CI , but there was no statistical significance . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Addition of apolipoprotein A 1 ( apoA 1 ) or apoB antibody to a normal CE transfer mixture did not alter CE transfer activity . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The net accumulation in the medium of apolipoprotein ( apo ) A 1 was not affected by the fatty acids tested and moderate changes in that of apoB resulted in apoB / apoA 1 mass ratios of 1 . 05 , 1 . 27 and 0 . 86 with linoleic , linolelaidic and palmitic acids , respectively . ^^^ These results suggest that relative to cis polyunsaturated and saturated fatty acids , trans PUFA more adversely affect the concentration and composition of apoA 1 and apoB containing lipoproteins secreted by HepG 2 cells . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Overexpression of SR BI by adenoviral vector promotes clearance of apoA 1 , but not apoB , in human apoB transgenic mice . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We measured plasma lipids , insulin , apoA 1 , apoB , and apoC 3 and assessed three polymorphisms in the apoC 3 gene , namely , T 455C in the IRE promoter region , C1100T in exon 3 , and Sst 1 polymorphic site ( S1 / S2 ) in the 3 ' untranslated region . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We investigated 178 patients who underwent complete cardiac examination comprising coronary angiography and biological analysis ( CT , HDL c , LDL c , TG , and apoAI , apoB , homocysteine and Lp ( a ) ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , triglyceride ( TG ) , apolipoprotein A 1 ( apoA 1 ) , apoliproprotein B ( apoB ) and insulin were measured in 137 subjects ; low density lipoprotein ( LDL C ) was calculated . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Total cholesterol ( TC ) , HDL ( HDL C ) and LDL cholesterol ( LDL C ) , triglycerides ( TG ) , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) , lipid peroxides as thiobarbituric acid reactive substances ( TBARS ) , thromboxane B 2 ( TXB 2 ) and 6 ketoprostaglandin F ( 1alpha ) ( 6 ketoPGF ( 1alpha ) ) concentrations were determined in blood samples drawn before and after each group was fed the different dietary regimens . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Except for the lower serum albumin levels in both dialyzed groups after six months lower ApoAI levels and higher ApoB levels were observed in HD and PD patients respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Anthropometric , blood pressure ( BP ) and other biochemical CVD risk factors including serum total cholesterol ( CHOL ) , triglyceride ( TG ) , high density lipoprotein cholesterol ( HDL C ) , apolipoprotein A 1 ( apoA 1 ) and B ( apoB ) and lipoprotein ( a ) [ Lp ( a ) ] were measured using standard methods . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We have compared the pairwise combinations of total cholesterol , triglycerides ( TGs ) , apoB , high density lipoprotein ( HDL ) cholesterol , low density lipoprotein cholesterol , and apoA 1 on CHD risk prediction in middle aged men . ^^^ The relative risk ( RR ) of CHD associated with cholesterol , TGs , apoB , apoA 1 , apoB / apoA 1 , low density lipoprotein cholesterol , and HDL cholesterol were examined by survival analysis . ^^^ The apoB / apoA 1 ratio was associated with the strongest effect on the RR ( 3 . 58 , 95 % CI 2 . 08 to 6 . 19 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fluvastatin reduced plasma levels of total cholesterol by 16 % , LDL C by 25 % , and ApoB by 16 % and increased plasma levels of HDL C by 9 % and apoA 1 by 7 % . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum total cholesterol ( Chol ) , HDL cholesterol ( HDL Chol ) , apolipoproteins A 1 ( ApoA 1 ) , B ( ApoB ) , E ( ApoE ) , ApoE phenotype , lipoprotein a ( Lpa ) , fibrinogen , C reactive protein ( CRP ) , systolic ( SBP ) and diastolic blood pressure ( DBP ) were assessed . ^^^ Serum levels of T and FT , correlated positively with HDL Chol and ApoA 1 with Spearman correlation coefficients , partialised for age and body mass index ( BMI ) , ranging between 0 . 14 and 0 . 17 ( P < 0 . 001 ) ; FT was associated with total Chol and ApoB levels ( r=0 . 12 for both T and FT ; P < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Plasma TC , LDL C , TG and apoB concentrations in CHD patients were all significantly increased , whereas HDL C and apoAI concentrations were decreased . ^^^ LDL IC concentrations were positively correlated with LDL C , apoB , TC , TG and Lp ( a ) concentrations , while negatively correlated with HDL C and apoAI concentrations , respectively . ^^^ Similarly , Lp ( a ) IC concentrations were positively correlated with Lp ( a ) , LDL C , apoB and TC concentrations , while negatively correlated with HDL C and apoAI concentrations , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The LDL cholesterol / HDL cholesterol and apoB / apoA 1 ratios were higher when women consumed the LSAFA diet than when they consumed the HSAFA diet . ^^^ The LDL / HDL cholesterol ratio was higher when women consumed either the LSAFA or the HSAFA diet than when they consumed the HUFA diet , whereas apoB / apoA 1 was higher when women consumed the LSAFA diet than when they consumed the HUFA diet . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum lipids , including TC , TG , LDL C , HDL C , apoB , apoA 1 and Lp ( a ) were detected . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The levels of serum lipids profile , including TC , TG , LDL C , HDL C , apoB , apoA 1 and Lp ( a ) were detected . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Hepatic expression of fatty acid binding protein , VLDL apolipoprotein ( apoVLDL 2 ) and apoB genes increased significantly ( P < 0 . 05 ) in both ad libitum and restricted breeders after photostimulation , whereas apoA 1 gene expression declined during this time . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : In whole blood stored at room temperature for up to 7 days , concentrations of albumin , apolipoproteins A 1 and B ( apoA 1 and apoB ) , cholesterol , high density lipoprotein ( HDL ) , total protein , and triglycerides changed by less than 4 % , and low density lipoprotein ( LDL ) by less than 7 % . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There were no statistically significant differences in total cholesterol , LDL , HDL , apoB or apoAI between carriers and non carriers . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In the healthy controls , associations were found for 14C > T genotypes with HDL C in Chinese ; 237indelG ( 5 ' UTR ) with apolipoprotein A 1 ( apoA 1 ) in Malays and total cholesterol ( TC ) in Indians ; M883I with lipoprotein ( a ) [ Lp ( a ) ] in Malays and apolipoprotein B ( apoB ) in Chinese ; and 8994A > G with Lp ( a ) in Malays , and TC , low density lipoprotein cholesterol ( LDL C ) as well as apoB in Indians . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Total cholesterol , LDL cholesterol , apoB , HDL cholesterol , and apoA 1 were significantly higher in children with diabetes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
These findings closely resemble those of the localization of apoA 1 and apoB 100 in human atherosclerotic lesions . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum TG , TC , LDL C , ApoB and ApoAI / ApoB were not significantly different among the three groups ( P > 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum lipid parameters ( total cholesterol ( TC ) , HDL C , LDL C , TG , apoA 1 , apoB , apoCIII ) , lipoprotein composition and LDL size were determined before initiation of lopinavir / ritonavir containing regimen , and at 1 and 3 months thereafter . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The relative abundance of LDL R mRNA and protein was compared with that of apolipoproteins A 1 ( apoA 1 ) and B ( apoB ) in enterocytes and two other cell types : CaCo 2 and HepG 2 . ^^^ Immunoprecipitation of [ ( 35 ) S ] methionine pulse labeled intracellular proteins from these cell types demonstrated that human enterocytes synthesize more apoA 1 and apoB , while HepG 2 cells synthesize a slightly higher amount of LDL R . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : The plasma total cholesterol , HDL cholesterol , triglyceride , lipoprotein ( a ) , ApoA 1 , ApoB , fibrinogen and Chlamydia Ig A , IgG and IgM antibody concentrations were examined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Interestingly , apoA 1 is detectable on apoB containing lipoproteins by sequential immunoprecipitation , suggesting that the two apoproteins co reside at least on a subfraction of the secreted particles , or that apoB and apoA 1 containing particles interact . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Xuezhikang significantly reduced fasting serum total cholesterol ( TC ) ( 20 % ) , low density lipoprotein cholesterol ( LDL C , 34 % ) , TG ( 32 % ) and apoB ( 27 % ) levels , and raised fasting high density lipoprotein cholesterol ( HDL C , 18 % ) and apoA 1 ( 13 % ) levels ( P < 0 . 001 ) . ^^^ The change of TG AUC was significantly related to the changes of fasting TG , TC , LDL C , and HDL C levels after the treatment , which were related to the changes of fasting apoA 1 and apoB levels significantly ( P < 0 . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum lipids include triglyceride ( TG ) , total cholesterol ( TC ) , high density lipoprotein cholesterol , low density lipoprotein cholesterol , apolipoprotein A 1 ( ApoA 1 ) and apolipoprotein B ( ApoB ) were also measured . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Cell types ( smooth muscle cells [ SMCs ] or macrophages ) , apolipoproteins ( apoA 1 , apoB , and apoE ) , and extracellular matrix proteoglycans ( biglycan and versican ) were identified on adjacent sections with monospecific antibodies . ^^^ PLTP also was detected in an extracellular distribution , colocalizing with apoA 1 , apoB , apoE , and the vascular proteoglycan biglycan . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In Hep G 2 cells , CP 346086 inhibited apolipoprotein B ( apoB ) and triglyceride secretion ( IC 50 2 . 6 nM ) without affecting apoA 1 secretion or lipid synthesis . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Within this framework , increased free testosterone was associated with increased apoB and decreased HDL C and apoAI , whereas increased estradiol was associated with increased HDL C and decreased triglycerides , low density lipoprotein cholesterol , and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In particular , lipid parameters not extensively investigated so far in previous case control studies specifically focused in the old population , such as lipoprotein Lp ( a ) and Apoproteins AI ( ApoAI ) and B ( ApoB ) , have been taken into account . ^^^ Fasting blood samples were collected within 48 h from admission , for determination of total cholesterol ( TC ) , triglycerides ( TG ) , High Density Lipoprotein cholesterol ( HDL C ) , Lp ( a ) , ApoAI and ApoB ; Low Density Lipoprotein Cholesterol ( LDL C ) was estimated by Friedwald formula . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Both hyperlipidemic and diabetic subjects had lower ratios of PAF AH to apoB ( P < 0 . 01 ) and higher ratios of PAF AH to apoA 1 ( P < 0 . 01 ) than did controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To evaluate the risk ApoA 1 and ApoB concentrations were measured and ApoA1 / ApoB index was calculated . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum concentrations of apolipoproteins A 1 and E ( apoA 1 and E ) of the KJP group were significantly lower than those of the control group , whereas no significant differences were observed in serum apoB and apoA 4 between the two groups . 5 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
OBJECTIVE : To determine the effect in children with intractable seizures of a high fat ketogenic diet on plasma levels of the major apolipoprotein B ( apoB ) containing lipoproteins , low density lipoprotein ( LDL ) and very LDL ( VLDL ) ; and the major apolipoprotein A 1 ( apoA 1 ) containing lipoprotein , high density lipoprotein ( HDL ) . ^^^ MAIN OUTCOME MEASURES : Differences at baseline and 6 month follow up for levels of total , VLDL , LDL , HDL , and non HDL cholesterol ; triglycerides ; total apoB ; and apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol ( TC ) , LDL cholesterol ( LDL C ) and HDL cholesterol ( HDL C ) , triglycerides ( TG ) , apolipoprotein A 1 ( ApoA 1 ) and apolipoprotein B ( ApoB ) levels were assessed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Fractions were assayed for total cholesterol ( TC ) , free cholesterol ( FC ) , phospholipid , triglyceride ( TG ) , apoE , apolipoprotein B ( apoB ) , and apolipoprotein AI ( apoAI ) . ^^^ Plasma sized apoB containing lipoproteins and a very small apoAI containing Lps were identified in the SAH CSF , which were not present in controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We show that 2 fold increased PLTP activity results in ( 1 ) a decrease in HDL cholesterol , HDL phospholipid , and apoAI levels ; ( 2 ) a decrease in vitamin E contents in total plasma and in individual lipoprotein fractions ; ( 3 ) an increase in lipoprotein oxidizability as assessed by copper induced formation of conjugated dienes ; ( 4 ) an increase in autoantibodies against oxidized apoB containing particles ; and ( 5 ) an increase in atherosclerosis lesions in proximal aorta . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Time main effects were also observed for cholesterol , ApoA 1 , ApoB , Factor 7 , diastolic blood pressure , and glucose . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Effects of atorvastatin versus fenofibrate on apoB 100 and apoA 1 kinetics in mixed hyperlipidemia . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Classification of plasma lipoproteins on the basis of apolipoprotein ( apo ) composition recognizes two lipoprotein ( Lp ) classes , one of which is characterized by apoA 1 and the other by apoB as major protein constituents . ^^^ As polydisperse systems of particles , the apoA 1 containing lipoproteins overlap in high density segments and apoB containing lipoproteins in low density segments of the density gradient . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Serum levels of apolipoprotein AI ( apoAI ) , apolipoprotein B ( apoB ) , high density lipoprotein cholesterol ( HDL C ) , triglyceride ( TG ) , and total cholesterol ( TC ) were measured in 120 chronic schizophrenia patients , 50 vascular dementia , and 100 normal controls by the enzyme method and immune fluoroscopy turbidimetric method . ^^^ RESULTS : The patients with schizophrenia and vascular dementia had significantly lower content of apoAI , HDL C , and apoAI / apoB than those in normal control ( P < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Triglyceride , LDL cholesterol ( LDLc , Friedewald / ultracentrifugation ) , high density lipoprotein HDL cholesterol ( HDLc , direct method ) , apolipoproteins AI ( apoAI ) and B ( apoB ) ( immunoturbidimetry ) , and LDL size ( gradient gel electrophoresis ) were measured at baseline and after improvement in glycemic control ( decrease > / = 1 percentage point in HbA ( 1c ) and final HbA ( 1c ) < / = 8 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
LDL IC levels were positively correlated with TC , TG , LDL C , lipoprotein ( a ) [ Lp ( a ) ] , and apolipoprotein B ( apoB ) concentration , while negatively correlated with apoA 1 concentration , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Group 1 subjects had lower HDL cholesterol ( p = 0 . 016 ) and apoA 1 levels ( p = 0 . 044 ) and higher apoB levels ( p = 0 . 029 ) and PWV ( p = 0 . 001 ) than group 3 control subjects . ^^^ Likewise , the apoB levels ( p = 0 . 007 ) and PWV ( p = 0 . 042 ) were higher in group 2 than in 3 subjects , although their HDL cholesterol ( p = 0 . 54 ) and apoA 1 ( p = 0 . 52 ) levels were similar . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
TC incubation decreased the secretion of endogenous rat apoB 100 ( 50 % ) and h apoB 18 ( 35 % ) , but did not affect secretion of rat apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The concentrations of plasma triglyceride , total cholesterol , low density lipoprotein cholesterol , high density lipoprotein cholesterol , lipoprotein ( a ) , apoA 1 , apoB ( 100 ) and apoE were measured . ^^^ The quantity of apoE gene expression was not associated with total cholesterol , triglyceride , high density lipoprotein cholesterol , lipoprotein ( a ) , apoA 1 , and apoB ( 100 ) ( correlation coefficient = 0 . 19 , 0 . 11 , 0 . 16 , 0 . 09 , 0 . 18 , 0 . 22 , P > 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The analyzed markers correspond to polymorphic sites in several candidate genes for cardiovascular disease including apolipopoteins and their receptors ( APOA 1 , APOB , APOE , APOC 1 , APOC 2 , LPA , and LDLR ) , genes implied in the hemostasis regulation ( Factor 7 , alpha and beta fibrinogen , alpha and beta platelet integrin , tissue plasminogen activator , and plasminogen activator inhibitor 1 ) , and the angiotensin converting enzyme gene . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHOD : The quantities of apoA 1 and apoB in the blood serum were tested by the ELISA method . ^^^ The apoB / apoA 1 ratio for patients with valve fibrotic damage was significantly higher as compared to controls in all groups ( P < 0 . 02 ) . ^^^ The increase of apoB / apoA 1 ratio in patients with rheumatic valve fibrosis was caused by lower apoA 1 levels in blood serum . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipoproteins were characterized by conventional lipid profile , nuclear magnetic resonance lipoprotein subclass profile ( NMR LSP ) , apoA 1 , apoB , lipoprotein ( a ) , and susceptibility of LDL to oxidation . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Glucose , lipids , lipoproteins , apoAI , apoB , lipoprotein ( a ) plasma concentration as well as apo ( a ) phenotypes were determined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : Total cholesterol , HDL C , LDL C , triglycerides , apoA 1 , apoB , apoCIII , lipoprotein composition , LDL size and LDL resistance to copper induced oxidation were determined before initiation of fenofibrate or Vitamin E , and 3 and 6 months thereafter . ^^^ Three months of fenofibrate treatment results in a significant decrease in triglycerides ( 40 % ) , apoCIII ( 21 % ) , total cholesterol ( 14 % ) , apoB ( 17 % ) levels , non HDL C ( 17 % ) , TG / apoA1 ratio in HDL ( 27 % ) associated with an increase in HDL C ( +15 % ) and apoA 1 ( +11 % ) levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Newborns born of mothers with APOE * E2 allele had significantly lower cord blood LDL C ( P < 0 . 01 ) and apoB ( P < 0 . 01 ) and significantly higher cord blood HDL C and apoA 1 ( all P values < 0 . 03 ) compared to those born of mothers with APOE * E3E3 genotype . ^^^ Similarly , APOC3 * S2 in mothers was associated with significantly lower ( all P < 0 . 001 ) cord blood LDL C , apoB , HDL C and apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
As a consequence of that , LDL C / HDL C and the apoB / apoAI ratios did not differ between patients with or without kidney involvement . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
There is a negative correlation between Lp ( a ) and HDL C ( r = 0 . 13 , p = 0 . 03 ) , Lp ( a ) and ApoA 1 ( r = 0 . 11 , p = 0 . 05 ) ; but there is a positive correlation between Lp ( a ) and ApoB ( r = 0 . 14 , p = 0 . 02 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : The levels of serum lipid profile , including TC , TG , HDL C , LDL C , ApoAI , ApoB were analyzed . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Dysregulation of lipoprotein metabolism in metabolic syndrome may be due to a combination of overproduction of VLDL [ very LDL ( low density lipoprotein ) ] apo ( apolipoprotein ) B 100 , decreased catabolism of apoB containing particles and increased catabolism of HDL ( high density lipoprotein ) apoA 1 particles . ^^^ Nutritional modifications may favourably alter lipoprotein transport in the metabolic syndrome by collectively decreasing the hepatic secretion of VLDL apoB and the catabolism of HDL apoA 1 , as well as by potentially increasing the clearance of LDL apoB . ^^^ Several pharmacological treatments , such as statins , fibrates or fish oils , can also correct the dyslipidaemia by diverse kinetic mechanisms of action , including decreased secretion and increased catabolism of apoB , as well as increased secretion and decreased catabolism of apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : The kinetics of apoA 1 within high density lipoprotein ( HDL ) , apoB 48 and apoB 100 within triglyceride rich lipoproteins , and apoB 100 within intermediate density lipoprotein and low density lipoprotein ( LDL ) were examined with a primed constant infusion of [ 5 , 5 , 5 ( 2 ) H ( 3 ) ] leucine in the fed state ( hourly feeding ) in 23 subjects after consumption of a 36 % total fat diet . ^^^ ApoA 1 production rate ( PR ) was correlated with LDL apoB 100 pool size ( PS ; r=0 . 49 ; P=0 . 017 ) and LDL cholesterol ( r=0 . 61 ; P=0 . 002 ) , whereas apoA 1 fractional catabolic rate ( FCR ) was inversely correlated with apoB 48 FCR ( r= 0 . 40 ; P=0 . 05 ) but not with very low density lipoprotein apoB 100 FCR . ^^^ CONCLUSIONS : Two links exist between apoA 1 and apoB kinetics : 1 ) when LDL apoB 100 PS is high , there is increased apoA 1 PR ; and 2 ) delayed chylomicron remnant clearance ( represented by apoB 48 FCR ) is associated with enhanced apoA 1 FCR , a finding indicating that alterations in intestinal lipoproteins may be more important in determining HDL cholesterol levels than changes in liver lipoproteins . ^^^ Using stable isotopes in humans , 2 links were observed between apoA 1 and apoB kinetics : ( 1 ) when LDL apoB 100 PS is high , there is increased apoA 1 PR ; and ( 2 ) delayed chylomicron remnant clearance is associated with enhanced apoA 1 FCR , indicating that alterations in intestinal lipoproteins may be more important in determining HDL C levels than changes in liver lipoprotein particles . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apoA 4 KDEL effect was specific , as neither KDEL modified forms of human serum albumin or apoA 1 affected apoB 41 secretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Atherogenic dyslipidemia in these patients may be caused by a combination of overproduction of very low density lipoprotein ( VLDL ) apoB 100 , decreased catabolism of apoB containing particles , and increased catabolism of HDL apoA 1 particles . ^^^ Therapeutic improvements in lipid and lipoprotein profiles in visceral obesity can be achieved by several mechanisms of action , including decreased secretion and increased catabolism of apoB , as well as increased secretion and decreased catabolism of apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In primary hepatocytes isolated from hHLmt expressing mice , the concentration of cell associated and secreted apoA 1 was decreased by 2 3 fold as compared with hepatocytes isolated from control mice , whereas the levels of apoB and apoE were unaltered . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
These patients had significantly lower HDL C , PON1 / HDL C , apoA 1 , PON1 / ApoA 1 , and ApoA I / ApoB , and higher LDL C , TC / HDL C , LDL C / HDL C , apoB , CD and TBARS than did controls . ^^^ After multiple logistic regression analysis , TBARS ( odds ratio [ OR ] 568 . 87 ; p = 0 . 000 ) , age ( OR 1 . 10 ; p = 0 . 000 ) , gender ( OR 4 . 58 ; p = 0 . 008 ) , apoA I / apoB ( OR 0 . 046 ; p = 0 . 003 ) , and PON1 / apoA 1 ( OR 0 . 58 ; p = 0 . 007 ) were independently indicative of the presence of CAD . ^^^ Our results indicate that TBARS levels , age , gender , apoA 1 / ApoB , and PON1 / apoA 1 ratios are important markers of CAD . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
HL WT and HL S145G reduced plasma cholesterol ( by 40 and 57 % , respectively ) , non high density lipoprotein cholesterol ( by 48 and 61 % , respectively ) , and apoB ( by 36 and 44 % , respectively ) ( p < 0 . 01 ) , but only HL WT decreased high density lipoprotein cholesterol ( by 67 % ) and apoA 1 ( by 54 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
BACKGROUND : The aim of the present study was to examine the serum lipid profile in obese Chinese children , their serum lipid and apolipoprotein A 1 ( apoA 1 ) and B ( apoB ) levels were examined . ^^^ Serum total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDLC ) , triglyceride ( TG ) , apoA 1 and apoB levels were also measured . ^^^ Anthropometric variables had no linear relationship to TC , HDLC , TG , LDLC , apoA 1 or apoB , but in the older age group ( over 10 years old ) % BW and % BF showed a weak correlation with HDLC ( r = 0 . 202 , r = 0 . 211 , respectively ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The plasma phosphatidylcholine concentration was reduced in the CTalpha knockout ( independent of gender ) , as were levels of high density lipoproteins ( cholesterol and apoAI ) and very low density lipoproteins ( triacylglycerols and apoB 100 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In group 2 and 3 there was a definite and up to 6 hours in duration postprandial hypertriglyceridemia associated with proatherogenic deviations in lipid and protein components ( LDL and HDL ) by FL hour 6 : growing of LDL cholesterol , apoB , apoB / apoAI and lowering of HDL cholesterol and apoAI . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
BACKGROUND AND PURPOSE : The apolipoprotein B ( apoB ) / apolipoprotein A 1 ( apoA 1 ) ratio is a measure of the relationship between different lipoprotein particles and a powerful predictor of coronary death . ^^^ The aim was to examine whether apoB / apoA 1 was associated with the metabolic syndrome ( MetS ) at baseline and also with the future change in carotid artery intima media thickness ( IMT ) . ^^^ RESULTS : ApoB / apoA 1 showed statistically significant associations with body mass index , waist to hip ratio , high density lipoprotein ( HDL ) cholesterol , triglycerides , low density lipoprotein ( LDL ) particle size , insulin , and diastolic blood pressure . ^^^ Two thirds of the patients with MetS had high apoB / apoA 1 ratios ( > 0 . 90 ) compared with one third of those without the syndrome ( P < 0 . 001 ) . ^^^ The subjects with apoB / apoA 1 above the first tertile ( 0 . 74 ) had a 20 microm higher ( 95 % CI , 7 to 33 ) annual increase in IMT compared with those below this level after adjustment for blood pressure and smoking . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol ( TC ) , low density lipoprotein ( LDL ) cholestrol and high density lipoprotein ( HDL ) cholesterol , triglyceride ( TG ) , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) and lipoprotein ( a ) ( Lp ( a ) ) levels were assessed in each subject at baseline , and at 6 and 12 months of therapy . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MEASUREMENTS : Plasma total apoA 4 , apoA 1 , apoB , plasma distribution of apoA 4 , leptin , lipids , and lipoproteins before and after 3 weeks of weight reduction . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
ApoA 1 was significantly increased ( P < 0 . 001 ) whereas ApoB was reduced ( P < 0 . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The usefulness of this database is demonstrated by performing a new autosomal genomic scan on apolipoprotein B ( apoB ) , LDL apoB , and apoA 1 levels , measured in 679 subjects of 243 nuclear families . ^^^ Only two loci provided support for linkage with both methods : a LDL apoB locus on 18q21 . 32 and an apoA 1 locus on 3p25 . 2 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Higher apoCIII concentrations were associated ( P < . 0001 ) with increased triglycerides ( r = 0 . 78 ) , total ( r = 0 . 61 ) and low density lipoprotein ( LDL ) ( r = 0 . 40 ) cholesterol , apoA 1 ( r = 0 . 26 ) , and apoB ( r = 0 . 50 ) , and these relationships persisted after controlling for age , gender , body mass index ( BMI ) , and hemoglobin A1c ( HbA1c ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At the end of each diet period , LDL particle size and plasma levels of total cholesterol , LDL cholesterol ( LDL C ) , HDL C , apoB , apoA 1 , and triacylglycerols were determined . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
It is concluded that plasma levels of apoB , apoAI , remnant like particle ( RLP ) C , lipoprotein ( a ) [ Lp ( a ) ] , and hs CRP in addition to those of lipids should be measured as predictors of atherosclerosis in clinical practice . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apoB / apoA 1 ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic lipoproteins and to predict coronary risk . ^^^ BACKGROUND : The apolipoprotein B ( apoB ) / apoA 1 ratio represents the balance of proatherogenic and antiatherogenic lipoproteins . ^^^ The purpose of this study was to determine whether the apoB / apoA 1 ratio was superior to any of the cholesterol ratios total cholesterol / high density lipoprotein cholesterol ( TC / HDL C ) , low density lipoprotein cholesterol ( LDL C ) / HDL C and non HDL C / HDL C in predicting the risk of coronary disease . ^^^ Moreover , we examined whether any lipids , lipoproteins or cholesterol ratios add significant predictive information beyond that provided by the apoB / apoA 1 ratio . ^^^ METHODS : Plasma lipids , lipoproteins , apoB , and apoA 1 were measured in 69 , 030 men and 57 , 168 women above 40 years of age . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
AIMS : To investigate the association between apolipoprotein B ( apoB ) , A 1 ( apoA 1 ) , the apoB / apoA 1 ratio , and the incidence of coronary events . ^^^ Furthermore , the predictive power of the apoB / apoA 1 ratio was similar to that of the total cholesterol / HDL cholesterol ratio in men and women . ^^^ CONCLUSION : ApoB and the apoB / apoA 1 ratio were strong predictors of coronary events in middle aged men and women , whereas apoA 1 did not add significantly to the estimation of future coronary risk . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
To better understand the effects of thyroid dysfunction on the development of atherosclerosis , we investigated plasma CRP and lipid profiles such as apoA 1 , apoB , and Lp ( a ) in cases with differing severities of thyroid dysfunction . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Higher apoCIII concentrations were associated ( P < . 0001 ) with increased triglycerides ( r= . 78 ) , total ( r= . 61 ) and LDL ( r= . 40 ) cholesterol , apoAI ( r= . 26 ) , and apoB ( r= . 50 ) , AER ( r= . 08 ) , and the severity of retinopathy ( ETDRS score , r= . 11 ) , and these relationships persisted after controlling for age , gender , body mass index ( BMI ) , and HbA1c level . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Other CAD risk factors such as serum levels of apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B , ( apoB ) , homocysteine ( Hcy ) , folate , and vitamin B 12 were also measured . ^^^ The serum apoA 1 / apoB ratio showed significant difference among the 3 apoE genotype groups ( p 0 . 0001 ) ; the apoA 1 / apoB ratio was 1 . 9 + / 0 . 1 ( mean + / SD ) in the epsilon 2 group , vs 1 . 4 + / 0 . 04 and 1 . 5 + / 0 . 12 in the epsilon 3 and epsilon 4 groups , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
An inverse J shaped relationship was assumed for ApoA 1 and ApoB / ApoA1 ratio , whereas a U shaped relationship was observed for serum triglycerides and mixed hyperlipidemia . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We conclude that apoE is a more significant activator of LCAT than apoA 1 on mouse apoB lipoproteins . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
BACKGROUND : Lower levels of plasma apolipoprotein AI ( Apo A 1 ) and higher levels of ApoB , and the ratio of ApoB to ApoA 1 are considered to be independent risk factors for coronary heart disease , and may assume importance in the definite subset of Indian patients with normal levels of traditional lipid risk factors and an early onset of coronary artery disease ( CAD ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : Immunohistochemistry was performed for SAA , apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , and perlecan on proximal aortic lesions from chow fed low density lipoprotein receptor ( LDLR ) / and apoE / mice euthanized at 10 , 50 , and 70 weeks . ^^^ SAA area correlated highly with lesion areas ( apoE / , r=0 . 76 ; LDLR / , r=0 . 86 ) , apoA 1 areas ( apoE / , r=0 . 88 ; LDLR / , r=0 . 80 ) , apoB areas ( apoE / , r=0 . 74 ; LDLR / , r=0 . 89 ) , and perlecan areas ( apoE / , r=0 . 83 ; LDLR / , r=0 . 79 ) ( all P < 0 . 0001 ) . ^^^ In vitro , SAA enrichment increased high density lipoprotein ( HDL ) binding to heparan sulfate proteoglycans , and immunoprecipitation experiments using plasma from apoE / and LDLR / mice demonstrated that SAA was present on both apoA 1 containing and apoB containing lipoproteins . ^^^ CONCLUSIONS : In chow fed apoE / and LDLR / mice , SAA is deposited in murine atherosclerosis at all stages of lesion development , and SAA immunoreactive area correlates highly with lesion area , apoA 1 area , apoB area , and perlecan area . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Women with high visceral AT and high IR had higher fasting and 2 h glycemia , triglyceride , and VLDL apoB levels ; lower apoAI and HDL ( 2 ) cholesterol levels ; as well as higher C reactive protein and interleukin 6 concentrations than women with low visceral AT and low IR ( P < 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total cholesterol , triglycerides , low density lipoprotein ( LDL ) and high density lipoprotein ( HDL ) cholesterol , and apolipoproteins A 1 ( ApoA 1 ) and B ( ApoB ) were measured and non HDL cholesterol calculated . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The very low density lipoprotein ( VLDL ) / LDL size fraction also contained a significant level of cholesterol in ABCA 1 deficiency , consistent with the result of immunoprecipitations showing the presence of lipoproteins with both apoA 1 and murine apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : Common pair wise genetic and environmental correlations among levels of total cholesterol ( TC ) , LDL C , ApoB , HDL C ( also HDL 2 C and HDL 3 C ) , triglycerides ( TG , HDL TG and LDL TG ) and ApoA 1 were investigated at baseline and again after a 20 week endurance exercise program using a variance components decomposition . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Each mutation showed complete co segregation with the FHBL phenotype in the families , and statistically significant differences between carriers and non carriers were found for plasma total , LDL , and HDL cholesterol , triglycerides , and APOB levels , but not for APOA 1 levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Total triglyceride and cholesterol ( c ) , LDLc , HDLc , non HDLc and apolipoproteins AI ( apoAI ) and B ( apoB ) were measured . ^^^ Changes in HDLc ( r = 0 . 358 , P = 0 . 001 ) , apoAI ( r = 0 . 355 , P = 0 . 003 ) , apoAI / apoB ratio ( r = 0 . 333 , P = 0 . 005 ) , weight ( r = 0 . 245 , P = 0 . 046 ) and BMI ( r = 0 . 253 , P = 0 . 039 ) correlated with that of HbA1c , but , in multivariate analysis , only changes in HDLc , apoAI and apoAI / apoB ratio were predicted by the decrease in HbA1c . ^^^ For the median observed change in HbA1c ( 3 . 3 percentage points ) , the estimated changes were +0 . 14 mmol / l , +0 . 12 g / l and +0 . 20 for HDLc , apoAI and apoAI / apoB ratio , respectively , accounting for 81 , 92 and 80 % of the observed changes . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Biochemical profiles of lipids and lipoproteins revealed markedly elevated levels of triglyceride , apoB and apoE , but approximately normal levels of total cholesterol , apoA 1 and lipoprotein ( a ) [ Lp ( a ) ] , which resembled familial hypertriglyceridemia . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Here , we show that the apoB independent pathway involves apoA 1 containing high density lipoproteins ( HDLs ) . ^^^ Cholesterol secretion by the HDLs , but not by the apoB pathway , was significantly reduced in primary enterocytes isolated from chow and cholesterol fed apoA 1 ( / ) mice . ^^^ These studies indicate that in apoA 1 deficiency , there is a delay in cholesterol absorption , but cholesterol is eventually absorbed because of the compensatory apoB pathway . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MATERIAL AND METHODS : Baseline s CRP was described in a population based sample of opposite sex , twin pairs ( 197 F , 189 M available for blood sampling ) aged 71 80 years ( mean age 74 . 5 years ) , considering mortality through the next 4 years , morbidity ( myocardial infarction , angina pectoris , congestive heart failure , arterial hypertension , venous thromboembolism , stroke , diabetes , gout , psoriasis , rheumatoid arthritis ) before and after blood sampling , biochemical values ( serum levels of urate , urea , ApoA 1 , ApoB , folate , FSH , LH , oestradiol , progesterone , testosterone , cortisol ) and anthropometric measurements ( body mass index ( BMI ) , circumference of waist , buttocks and hips ) . ^^^ The s CRP level was associated with serum levels of urate , progesterone , folate , ApoA 1 , ApoB and the quotient ApoB / ApoA1 as well as with BMI and waist circumference . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Peak expression of apoB and apoA 1 occurs in the first 25 % of the intestine ; however , expression in the most distal segments of the intestine is 10 % 15 % of maximum expression . ^^^ In mice fed a Western diet for 3 weeks the expression of MTP and CRBPII was elevated in the distal regions of the intestine , whereas the expression patterns for apoB and apoA 1 were similar to those found in mice on control diets . ^^^ However , the expression and regulation of these two proteins differ from those of apoB and apoA 1 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Furthermore , we examined apoAI , apoB and apoE by Northern blotting analyses . ^^^ The results demonstrated that leptin does not significantly influence the expressions of apoAI , apoB and apoE in HepC 2 cells , suggesting that leptin has a specific regulatory effect on hepatic apoM transcription and secretion in vitro . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
MAIN OUTCOME MEASURES : Primary outcome was the change in apolipoprotein B ( apoB ) and apoB / apolipoprotein A 1 ( apoA 1 ) ratio , which has been suggested a better predictor for cardiovascular events than total ( TC ) or low density lipoprotein cholesterol ( LDL C ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS AND RESULTS : Serum total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , triglycerides ( TG ) , apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , atherogenic index ( AI ) and apoA 1 / apoB ratio were determined in 17 male New Zealand white rabbits fed a cholesterol plus corn oil diet ( control group ) or the same diet supplemented with aspartate and glutamate ( Asp+Glu group ) for 4 weeks . ^^^ Both diets were found to increase TC , LDL C , apoB and AI , while apoA 1 / apoB ratio was decreased compared to baseline values . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Both peaks contained apoB and apoA 1 , RPE and retina contained apoA 1 mRNA transcripts , and BrM and drusen contained apoA 1 immunoreactivity . ^^^ Evidence of intraocular apoB and apoA 1 expression supports an emerging hypothesis that the RPE assembles and secretes a large , possibly novel , lipoprotein particle . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
White CC homozygotes had lower baseline HDL cholesterol , apoA 1 , LDL cholesterol , and apoB levels that remained low post exercise training . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : We investigated in a median follow up of 3 . 9 years the association of HDL , apolipoprotein A 1 ( apoA 1 ) , LDL , apolipoprotein B ( apoB ) , and triglycerides with the incidence of a combined endpoint ( myocardial infarction and cardiovascular death ) and their relation to markers of inflammation in 1298 patients with angiographically documented CAD . ^^^ RESULTS : In univariate analysis , serum concentrations of apoA 1 were significantly and inversely related to the combined endpoint , whereas serum concentrations of LDL , apoB , and triglycerides were not . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At the end of the 10th week , the levels of serum total cholesterol ( TC ) , triglycerides ( TG ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein A ( 1 ) ( ApoA 1 ) and apolipoprotein B ( ApoB ) were tested in each group , and the ultrastructures of the aorta were also observed by an electron microscope . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Genome scans were performed in 701 dizygotic twin pairs from four samples with data on plasma levels of HDL and LDL cholesterol and their major protein constituents , apolipoprotein AI ( ApoAI ) and Apolipoprotein B ( ApoB ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The present study was undertaken to determine whether policosanol could change some characteristic features of atherosclerotic lesions , such as macrophage number and immunohistochemical localization of apoA 1 and apoB in aortas of M . arctoides monkeys . ^^^ Monoclonal antibodies were used to evaluate the presence of macrophage , apoA 1 and apoB . ^^^ RESULTS : Policosanol reduced the presence of macrophages and the occurrence of apoB , whereas increased apoA 1 localization in aortic atherosclerotic lesions compared with control monkeys . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
This study compares the frequencies of seven APO ( APOA 1 75 bp , APOA 1 +83 bp , APOB Ins / Del , APOB XbaI , APOC 3 SstI , and APOE ) and LPL loci in Mennonite populations from Kansas and Nebraska . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipid and apolipoproteins ( ApoAI , ApoB , Apo CIII , ApoE ) disturbance in hemodialysis ( HD ) and renal transplant ( Tx ) patients . ^^^ There were significantly increased TG , ApoAIII , ApoE , TC / HDL C , ApoCIII non B , ApoCIII : B and decreased HDL C , ApoAI , HDL C / ApoAI , ApoAI / ApoCIII , ApoB / ApoCIII ratios comparing HD patients to the control group . ^^^ There were increased TG , ApoCIII , ApoCIII non B , ApoB / ApoCIII ratios and decreased ApoAI / ApoCIII ratios in Tx patients as compared to the control subjects . ^^^ Moreover , there were significantly higher HDL , ApoAI , HDL / ApoAI , ApoCIII non B and lower ApoE , ApoE / ApoB , ApoCIII : B ratios in Tx patients as compared to these of HD patients . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In normolipidemic females , 734C > T was associated with apoA 1 , apoB and lipoprotein ( a ) in Indians , and with apoA 1 in Malays , whereas 41A > G is associated with total cholesterol in Indians . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Finally , we showed that the previously reported association of newly synthesized apoA 1 and apoB ( Zheng , H . , Kiss , R . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
RESULTS : Patients had significantly lower levels of total cholesterol ( 125+ / 4 . 5 vs . 207+ / 7 mg / ml , p < 0 . 01 ) , ApoA 1 ( 120+ / 3 vs . 129+ / 5 mg / ml , p < 0 . 05 ) , ApoB ( 60 . 5+ / 2 vs . 95+ / 4 mg / ml , p < 0 . 01 ) , ApoE ( 3+ / 2 vs . 4+ / 0 . 2 mg / ml , p < 0 . 01 ) and Lp ( a ) ( 7 . 9+ / 1 . 3 vs . 14 . 5+ / 3 . 2 mg / ml , p < 0 . 01 ) than controls . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Serum concentrations of lipids and lipoproteins were measured by enzymatic methods ; apolipoproteins ( ApoA 1 and ApoB ) and serum lipoprotein ( a ) Lp ( a ) were measured by immonoprecipitation assays . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
At the same time , HDL cholesterol ( HDL C ) and apolipoprotein A 1 ( ApoA 1 ) were significantly increased in relation to baseline values and CG ( p < 0 . 05 ) and apolipoprotein B ( ApoB ) , total cholesterol / HDL C , LDL cholesterol / HDL C , and ApoB / ApoA1 ratios significantly decreased compared to baseline values and CG ( p < 0 . 05 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Analysis showed that the level of apoB mRNA was lower in cultures supplemented with octanoate than in the control cultures , but no significant changes were observed in the levels of apolipoprotein A 1 , fatty acid synthase and 3 hydroxy 3 methylglutaryl CoA reductase mRNA as a result of octanoate treatment . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Moderate ( 60 % ) DE gave rise to antiatherogenic changes in the blood : a fall in lipoproteins containing apoB and a rise in concentration of apo AI both in healthy and CHD subjects . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Combination therapy reduced total plasma TG ( 28 % ) , LDL cholesterol ( LDL C , 10 % ) , apoB ( 16 % ) , apoB / apoA 1 ratio ( 21 % ) while increasing HDL cholesterol ( HDL C , 21 % ) , total plasma apoA 1 ( 12 % ) , LpA 1 ( 43 % ) , and apoC 1 ( 26 % ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma APOB and LDL C , but not APOA 1 and HDL C , were shown to be markedly elevated in smokers versus non smokers , affirming that smoking may selectively impact the former pathway . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Patients with CHD compared with controls had increased serum levels of triglyceride , total cholesterol , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein B ( apoB ) , lipoprotein ( a ) [ Lp ( a ) ] and decreased serum levels of high density lipoprotein ( HDL ) C and apoAI . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We measured total cholesterol ( TC ) , triglyceride , LDL cholesterol , high density lipoprotein ( HDL ) cholesterol , ApoA 1 , ApoB , and Lp ( a ) levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Lipid parameters ( total cholesterol , LDL C , HDL C , Apo AI and ApoB ) were determined by an autoanalyser , paraoxonase and arylesterase activities were measured spectrophotometrically . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Stroke mortality and the apoB / apoA 1 ratio : results of the AMORIS prospective study . ^^^ The main objective of the present study was to determine if the risk of stroke is related to the balance between the proatherogenic apoB lipoprotein particles and the antiatherogenic apoA 1 particles as is the case for myocardial infarction . ^^^ The prospective risk and the relationships between five different types of fatal strokes and the lipid fractions , apoB , apoA 1 and the apoB / apoA 1 ratio ( automated immunoturbidimetry ) were examined . ^^^ High apoB and low apoA 1 values were significantly related to risk of stroke . ^^^ The odds ratio comparing the upper 10th versus the 1st decile of the apoB / apoA 1 ratio for all strokes adjusted for age , gender , total cholesterol ( TC ) and triglycerides ( TG ) was 2 . 07 ( 95 % CI : 1 . 49 2 . 88 ) , P < 0 . 0001 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
IGF 1 , insulin , glucose , triglycerides , total cholesterol , HDL cholesterol , HDL 2 cholesterol , HDL 3 cholesterol , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) and homocysteine levels were not modified by DHEA treatment . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
SDS PAGE showed a significant increase in apolipoprotein B ( apoB ; P < 0 . 01 ) but no changes in apoA 1 levels . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
After fluvastatin therapy , LDL ( 51 % ; P < . 01 ) , apolipoprotein B ( ApoB ; 33 % ; P < . 01 ) , intermediate density LDL ( idLDL ) ( 14 . 3 % ; P < . 05 ) , sdLDL ( 45 % ; P < . 01 ) , and triglycerides ( 38 % ; P < . 01 ) were significantly decreased , and HDL ( +14 . 3 % ; P < . 05 ) and apolipoprotein A 1 ( ApoA 1 ; +7 % ; P < . 05 ) were increased ; large buoyant ( lb ) LDL did not change ( P=NS ) . ^^^ Simvastatin therapy decreased LDL ( 55 . 1 % ; P < . 01 ) , ApoB ( 46 % ; P < . 01 ) , lbLDL ( 33 . 3 % ; P < . 05 ) , idLDL ( 22 . 7 % ; P < . 05 ) , sdLDL ( 33 . 3 % ; P < . 05 ) , and triglycerides ( 47 . 9 % ; P < . 01 ) ; HDL was not changed ( P=NS ) after simvastatin , but ApoA 1 was increased ( +11 . 3 % ; P < . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
In majority of the reports in HCC , plasma levels of triglycerides ( TG ) , cholesterol , free fatty acids ( FFA ) , HDL , low density lipoproteins ( LDL ) , lipoprotein ( a ) ( Lp ( a ) ) , apolipoprotein AI ( apoAI ) and apoB were slight to significantly decreased , however , in some cases plasma levels of TG and Lp ( a ) might be increased . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The aim of this population based study was to compare the association of non HDL cholesterol , ApoB and the ApoB : ApoA 1 ratio with cardiovascular mortality in people with type 2 diabetes . ^^^ ApoB and ApoB : ApoA 1 were associated with outcome in people in both age groups independently of non HDL cholesterol . ^^^ After adjustment for multiple factors , including non HDL cholesterol , the hazard ratios for ApoB : ApoA 1 in the upper vs lower quartile were 2 . 98 ( 95 % CI 1 . 15 7 . 75 ; p for trend=0 . 009 ) for people aged < or =70 years and 1 . 94 ( 95 % CI 1 . 20 3 . 13 ; p for trend=0 . 003 ) for those aged > 70 years . ^^^ CONCLUSIONS / INTERPRETATION : In this cohort of Mediterranean subjects with diabetes , ApoB and the ApoB : ApoA 1 ratio were associated with cardiovascular disease mortality independently of non HDL cholesterol . ^^^ Our findings support the recommendation that ApoB and ApoA 1 should be measured routinely in all people with diabetes , particularly in the elderly . . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We found no significant association between the APOE promoter genotypes and serum lipids [ low density lipoprotein cholesterol ( LDL C ) , HDL C , and triglycerides ] , apolipoproteins ( apoA 1 and apoB ) , or brachial artery FMD , CAC , or carotid IMT in either men or women . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Biochemical parameters included serum urea , creatinine , total cholesterol , triglyceride , HDL cholesterol , LDL cholesterol , apolipoprotein A 1 ( ApoA 1 ) , apolipoprotein B ( ApoB ) , lipoprotein ( a ) , homocysteine , and high sensitive CRP ( hs CRP ) . ^^^ The levels of ApoA 1 , ApoB , and lipoprotein ( a ) were similar , whereas the LDL / HDL cholesterol ratio and homocysteine levels were significantly higher in the CAN+ group ( P = . 04 , P = . 04 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
CIMT was positively associated with current height , and with low density lipoprotein ( LDL ) cholesterol and apolipoprotein B ( ApoB ) levels , and LDL / high density lipoprotein ( HDL ) cholesterol and ApoB / apolipoprotein AI ( ApoAI ) ratios . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
LVM , cIMT , and fIMT correlated with 24 h SBP and pulse pressure ; LVM also correlated with homocysteine and serum uric acid concentrations . fIMT correlated with low Aprotein A 1 ( ApoA 1 ) , higher ApoB and C reactive protein , and daily sodium excretion . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
We showed that siApoB lentivirus specifically knocked down apoB but had no effects on other proteins such as apoAI and albumin . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
DATA SOURCES : Prospective studies in essentially general populations that reported on associations between apoAI , apoB or apoB / A and first incident CHD outcomes . ^^^ CONCLUSIONS : The present quantitative review suggests the existence of moderately strong associations between baseline levels of each of apoAI , apoB , and apoB / A and risk of CHD . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The apoB / apoA 1 ratio : a strong , new risk factor for cardiovascular disease and a target for lipid lowering therapy a review of the evidence . ^^^ During the last several years interest has focused on the importance of the lipid transporting apolipoproteins apoB transports all potentially atherogenic very low density lipoprotein ( VLDL ) , intermediate density lipoprotein ( IDL ) and LDL particles , and apoA 1 transports and acts as the major antiatherogenic protein in the HDL particles . ^^^ The evidence for the apoB / apoA 1 ratio being a strong , new risk factor for cardiovascular ( CV ) disease and a target for lipid lowering therapy is reviewed . ^^^ The cholesterol balance determined as the apoB / apoA 1 ratio has repeatedly been shown to be a better marker than lipids , lipoproteins and lipid ratios . ^^^ The results indicate that the apoB / apoA 1 ratio is a simple , accurate and new risk factor for CV disease the lower the apoB / apoA 1 ratio , the lower is the risk . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Mass spectrometry showed that the apoM containing lipoproteins also contained apoJ , apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , paraoxonase 1 , and apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ratios ApoA 1 / ApoB , HDL C / ApoA 1 , LDL C / Apo B , which were closely related to the size of LDL particles , where correlated with Zn / Cu ( P < 0 . 001 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The odds ratio ( OR ) of PMI was 8 . 9 fold greater in the highest tertile of apoB / apoA 1 distribution compared with the lowest tertile . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
METHODS : In a cross sectional study in a university clinic setting , 129 patients ( 72 women and 57 men ) underwent colour fundus photography , acuity and contrast sensitivity assessment , and electroimmunoassays of plasma apolipoproteins B ( apoB ) and A 1 ( apoA 1 ) , the principal proteins of low density and high density lipoproteins , respectively . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Four weeks before and after treatment , the levels of fasting serum total cholesterol ( TC ) , triglyceride ( TG ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apolipoprotein A 1 ( apoA 1 ) and apolipoprotein B ( apoB ) were detected with biochemical techniques . ^^^ After 4 weeks of treatment , the levels of TC , TG , LDL C , and apoB significantly decreased ( P < 00 . 01 ) , and the levels of HDH C and apoA 1 significantly increased ( P < 0 . 01 ) . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Plasma lipoprotein analysis shows marked reductions in HDL cholesterol and phospholipids , increases non HDL lipids , decreases apolipoprotein A 1 ( apoA 1 ) , and increases apoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The cellular ability to secrete apoB and apoA 1 was not affected by SND p 102 differential expression , nor was that of lipoproteins triglyceride , cholesterol and cholesteryl esters . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
BACKGROUND : Apolipoprotein AI ( ApoAI ) and ApoB are risk indicators of cardiovascular disease . ^^^ We describe the use of immunoresonance scattering to measure the ApoAI and ApoB in serum . ^^^ METHODS : We used a trisodium citrate method to prepare 9 . 0 nm gold nanoparticles labeled with goat anti human ApoAI and ApoB antibodies . ^^^ The immune reaction between gold labeled antibodies and antigens took place in Na2HPO4 NaH2PO4 buffer solution ( pH 6 . 4 for ApoAI and pH 6 . 0 for ApoB ) in the presence of 75 g / L polyethylene glycol ( PEG ) . ^^^ The intensity ( DeltaI ) was proportional to concentration at 0 . 00833 0 . 3333 mg / L ApoAI and 0 . 00197 0 . 1972 mg / L ApoB . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
The ratio of apoB / apoAI , apoB and lipoprotein ( a ) are the best predictors of stable coronary artery disease . ^^^ Multiple logistic regression analysis after adjusting for major risk factors showed that the apoB / apoAI ratio , apoB and Lp ( a ) were among seven significant and independent determinants of CAD . ^^^ The area under the receiver operating characteristic ( ROC ) curves ( AUC ) as a relative measure of test efficiency was highest and significant for the apoB / apoAI ratio ( AUC=0 . 71 , p < or =0 . 0001 ) , apoB ( 0 . 67 , p < or =0 . 0001 ) , Lp ( a ) ( 0 . 63 , p < or =0 . 001 ) , the LDL C / apoB ratio ( 0 . 62 , p < or =0 . 006 ) , triglycerides ( 0 . 62 , p < or =0 . 004 ) and apoAI ( 0 . 58 , p < or =0 . 05 ) . ^^^ ANOVA analysis showed significant association for the apoB / apoAI ratio , apoB , Lp ( a ) and triglycerides , and moderate association for total cholesterol and its subfractions , with the severity of CAD . ^^^ CONCLUSIONS : The results indicate that the apoB / apoAI ratio , apoB and Lp ( a ) are independent risk factors for CAD and are superior to any of the cholesterol ratios . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
Dysregulation of lipoprotein metabolism in these subjects may be due to a combination of overproduction of very low density lipoprotein ( VLDL ) apoB 100 , decreased catabolism of apoB containing particles and increased catabolism of HDL apoA 1 particles . 2 . ^^^ Plant sterols ( phytosterols ) did not have a significant effect on plasma concentrations of lipids and lipoprotein or the kinetics of apoB and apoA 1 . 5 . ^^^
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
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Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA
Interacting proteins: P04114 and P02647 Pubmed SVM Score :0.0
NA