Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
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Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NA
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
When a comparison was made of the adsorption of iodinated apoproteins to ascites cells , 3 to 4 times more apoA 2 and apoC 3 were bound than apoA 1 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The binding of a constant amount of dimyristoyl lecithin to apoprotein mixtures containing various proportions of apoA 1 and apoC 3 failed to demonstrate the existence of any preferential association between the two apoproteins , in contrast with results obtained previously with apoA I / apoA 2 protein mixtures . ^^^ A classification of the apolipoproteins according to their lipid binding affinity is proposed as : apoA 2 congruent to apoC 3 greater than apoC 1 greater than apoA 1 proteins . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Low density lipoprotein , very low density lipoprotein , ApoA 1 , ApoC 2 , and ApoC 3 displaced no counts . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 1 from HDL , apoB from LDL , and apoC 3 from VLDL , as well as neutral lipid , were all localized to connective tissue and extracellular lipid pools in atherosclerotic lesions , and only to areas of intimal thickening in grossly `` uninvolved ' ' arteries . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 1 from high density lipoproteins , apoB from low density lipoproteins , and apoC 3 from very low density lipoproteins were localized also as markers for their respective lipoproteins , since the latter cross react immunologically . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The patients also had reduced levels of ApoA 1 and ApoA 2 , increased levels of ApoC 2 and ApoC 3 , while increases in levels of ApoB and ApoE were statistically significant in patients with GFR < 20 ml / min . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Characterization of the mouse apolipoprotein Apoa 1 / Apoc 3 gene locus : genomic , mRNA , and protein sequences with comparisons to other species . ^^^ The almost 9 kb of genomic sequence presented extends from 1298 bp 5 ' to the apolipoprotein A 1 ( Apoa 1 ) gene to 1249 bp 5 ' to the apolipoprotein CIII ( Apoc 3 ) gene . ^^^ The clustering and genomic organization of the mouse Apoa 1 and Apoc 3 genes are similar to those of the rat and human genes . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The cholesterol removal by the microemulsion was enhanced by some 30 % only when apoA 1 , A 2 , and E were present in excess to provide their free forms in the medium , but apoC 3 did not show such an effect even by its excess amount . ^^^ Thus , the data were consistent with a model that the free form of certain apolipoproteins , such as apoA 1 , A 2 , and E but not apoC 3 , generates pre beta HDL like particles with cellular lipids in situ and these particles act as mediators for cholesterol transfer from the cells to other lipoproteins . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Apo CI , apo CII and apo CIII were expressed only in liver and apo AI mRNA was detected only in small intestine . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Polymorphisms in the apolipoprotein ( apo ) AI CIII AIV gene cluster : detection of genetic variation determining plasma apo AI , apo CIII and apo AIV concentrations . ^^^ We have examined the associations between levels of plasma apolipoprotein ( apo ) AI , apo CIII and apo AIV and genetic variation in the apo AI CIII AIV gene cluster in 162 boys and young men from Belgium aged from 7 to 23 years . ^^^ Our results show that variation associated with some of the polymorphisms in the apo AI CIII AIV cluster makes a small , but statistically significant , contribution to the determination of apo AI and apo CIII levels in this sample of young men and boys . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Results show that there are no apo B 100 , CII or trace apo CIII in human cerebrospinal fluid , the levels of apo AI in cerebrospinal fluid are 1 . 00 + / 0 . 54 mg / dl with a range of 0 . 35 2 . 00 mg / dl and the apo E content is 0 . 69 + / 0 . 16 mg / dl with a range of 0 . 51 0 . 99 mg / dl . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Variation at the apo AI / CIII / AIV gene complex is associated with elevated plasma levels of apo CIII . ^^^ This study shows in the healthy `` English ' ' population that the S 2 allele is associated with elevated plasma apo CIII levels but not with low apo AI levels . ^^^ Regression analysis shows in both men and women that apo CIII levels are positively correlated with plasma triglyceride levels and moreover that they are a stronger predictor of this parameter than apo AI , B or AIV . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The allele frequencies for apo AI ( MspI and PstI ) , apo CIII ( Sst ) and apo B ( XbaI ) gene RFLPs were typical for larger population studies . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
GFR was positively correlated with ApoA 1 and inversely correlated with TC , TG and ApoC 3 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The pathway of the regulation of apo CIII and AI expression derived from the experiments described here is supported by mutations in the intergenic region , leading to the phenotype of hypertriglyceridemia , and the stimulatory effect of cholesterol on apo AI transcription in Hep G 2 cells . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In LpA I / A 2 , the levels of lipids , except for triglyceride , the levels of apoC 3 , and the ratio of apoA 1 to apoA 2 were significantly higher in IDDM . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The triglyceride rich VLDL contained mainly apoE ( 75 % ) and apoB ( 23 % ) , while the protein moiety of LDL was composed of apoB ( 59 % ) , apoE ( 20 % ) , apoA 1 ( 15 % ) , and apoC 3 ( 6 % ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Chromosome 11q23 includes these markers : STMY , CLG , NCAM , DRD 2 , APOA 1 , APOC 3 , APOA 4 , CD3E , CD3D , CD3G , PBGD , THY 1 , ets 1 , and cbl 2 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In addition to apoA 1 , apoA 2 and apoC 3 reported here , other apolipoprotein genes such as apoC 2 and apoE genes were found to share common intron exon organizations . ^^^ Utilizing cDNA as hybridization probes , we have localized apoA 1 , apoA 2 , apoC 2 , apoC 3 , apoE and apoB to specific locations of individual chromosomes ( for review , see ref . 6 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The association between the minor RFLP alleles and polymorphic gene variants ( probably the apo AI , apo CIII , or both genes ) which enhance liability to CHD accounted for almost 20 % of total CHD in this population . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The two forms of hypertriglyceridemia showed different apolipoprotein profiles : apo AI , AII , and B levels and apo CII : CIII and TG : apo CIII ratios of CRF HTG patients were lower and apo CIII levels were higher than the levels of type 4 subjects . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In family studies 10 heterozygotes were identified whose mean apoA 1 , apoC 3 , apoA 4 , and HDL cholesterol levels were 67 , 57 , 65 , and 62 % of normal . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The apo AI and the correctly oriented apo CIII genes separated by 2 . 6 kb were obtained by fusion of two human lambda genomic clones . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We have studied the frequency of DNA polymorphisms in and around the apolipoprotein A 1 ( Apo A 1 ) and apolipoprotein CIII ( Apo CIII ) gene loci in 53 persons of Caucasian descent with genetic hyperlipidemias . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes for apoE , apoC 1 , apoC 2 , apoC 3 , apoA 1 , apoA 2 and apoA 4 have similar structures , consisting of four exons and three introns , which suggests that they evolved from a common ancestral gene . ^^^ The apoA 1 , apoC 3 and apoA 4 genes are linked closely within a 20 kilobase ( kb ) span of chromosome 11 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes coding for apolipoproteins A 1 , C 3 , and A 4 ( APOA 1 , APOC 3 , APOA 4 ) are closely linked and tandemly organized within a 15 kilobase ( kb ) DNA segment on the long arm of human chromosome 11 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The apolipoproteins fall into two groups : the typical apolipoproteins ( apo AI , apo AII , apo AIV , apo CI , apo CII , apo CIII and apo E ) constitute a multigene family with strong similarities in structure , genomic organization and in functional domains . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Statistical analysis of sequence similarities between human apoC 2 , apoC 3 , apoA 2 , apoA 1 , apoE , and apoA 4 , and dog apoC 2 and apoC 3 , and rat apoC 3 , apoA 2 , apoA 1 , apoE , and apoA 4 indicates that all these proteins have evolved rapidly , especially in the rat in which apoC 3 has evolved at three times the rate in man and dog . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We have recently reported that the human apolipoprotein A 1 ( apoA 1 ) and apolipoprotein C 3 ( apoC 3 ) genes are physically linked and that the presence of a DNA insertion in the apoA 1 gene is correlated with apoA 1 apoC 3 deficiency in patients with premature atherosclerosis . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The Intro exon structure of the apo All gene is similar to that of the apo AI , apo CIII and apo E genes : three introns separate 4 coding sequences specifying the 5 ' untranslated region , pre peptide , a short N terminal domain and a C terminal domain composed of a variable number of lipid binding amphipathic helices . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes coding for three of the proteins of the lipid transport system , apolipoproteins A 1 ( apoA 1 ) , C 3 ( apoC 3 ) , and A 4 ( apoA 4 ) , are closely linked and tandemly organized as a multigene family in the human genome . ^^^ Low stringency hybridization blotting analysis of this DNA fragment using human apoC 3 and apoA 4 cDNA probes revealed that the apoA 1 , apoC 3 , and apoA 4 genes are also closely linked and tandemly organized in the rat genome . ^^^ Complete characterization of the rat apoA 1 , apoC 3 , and apoA 4 genes showed that their relative location , size , direction of transcription , and intron exon organization are remarkably similar to those of the corresponding human genes . ^^^ The relative steady state apoA 1 , apoC 3 , and apoA 4 mRNA levels in various rat tissues were determined by quantitative dot blot hybridization of tissue total RNA using the corresponding gene probes . ^^^ Adult liver and intestine , but not colon , brain , spleen , muscle , heart , lung , and kidney , contain apoA 1 , apoC 3 , and apoA 4 mRNAs . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The apoC 2 , apoC 3 , apoA 1 , apoE , and apoA 4 were present as minor components in ratios that were the reverse of those seen for the PC stabilized particles , which contained these proteins as major components . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes coding for three proteins of the plasma lipid transport system apolipoproteins A 1 ( APOA 1 ) , C 3 ( APOC 3 ) , and A 4 ( APOA 4 ) are closely linked and tandemly organized on the long arm of human chromosome 11 . ^^^ In contrast to APOA 1 and APOC 3 genes , which contain three introns , the APOA 4 gene contains only two . ^^^ An intron interrupting the 5 ' noncoding region of the APOA 1 and APOC 3 mRNAs is absent from the corresponding position of the APOA 4 mRNA . ^^^ However , similar to APOA 1 and APOC 3 genes , the introns of the APOA 4 gene separate nucleotide sequences coding for the signal peptide and the amphipathic domains in APOA 4 . ^^^ These results suggest that the APOA 1 , APOC 3 , and APOA 4 genes were derived from a common evolutionary ancestor and indicate that during evolution the APOA 4 gene lost one of its ancestral introns . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
By technique b , Tangier low molecular mass lipoproteins were dissociated into their constituent apolipoproteins , and we observed a higher proportion of apoC 3 , together with lower proportions of apoA 1 and apoA 2 , than in the normal HDL fraction . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes coding for apolipoproteins ( apo ) AI , CIII , and AIV , designated APOA 1 , APOC 3 , and APOA 4 , respectively , are closely linked and tandemly organized in the long arm of the human chromosome 11 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Furthermore , they obtained evidence for the occurrence in human plasma of small amounts of lipoproteins containing apoA 2 but not apoA 1 , apoB , apoC 2 , apoC 3 or apoE . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We found that liver is the sole or major site of synthesis of apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , and apoE , and the intestine is a major site of synthesis of apoA 1 , apoA 4 , and apoB . ^^^ Minor sites of apolipoprotein mRNA synthesis were as follows : apoA 1 , liver and skeletal muscle ; apoA 4 , spleen and lung ; apoB , kidney ; apoC 2 and apoC 3 , intestine . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We have determined concentrations of apoC 2 and apoC 3 in VLDL and HDL in subjects with a wide range of VLDL triglyceride and HDL cholesterol levels , and correlated these levels with fractional catabolic rates ( FCR ) of VLDL triglyceride and HDL apolipoprotein A 1 ( apoA 1 ) . ^^^ In HDL , concentrations of apoC 3 and apoA 1 were correlated ( r = 0 . 73 ; P less than 0 . 005 ) while no correlation was observed between apoC 2 and apoA 1 levels . ^^^ Univariate analyses of HDL variables revealed inverse correlations between the concentration of apoC 3 and the FCR for apoA 1 ( r = 0 . 67 ; P less than 0 . 005 ) and between the ratio of apoC III / apoA 1 and the FCR for apoA 1 ( r = 0 . 66 ; P less than 0 . 005 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In a 3 h perfusion , 21 % of SAA was degraded in contrast to 13 % of apoC 3 , 7 % of apoA 1 , and 6 % of apoA 2 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
CRF patients had reduced concentrations of ApoA 1 and ApoA 2 , normal levels of ApoB and ApoC 1 , and increased concentrations of ApoC 2 and , in particular , of ApoC 3 . ^^^ In comparison with type 4 , hyperlipoproteinemic patients , CRF patients had lower concentrations of ApoA 1 , ApoA 2 , ApoB , ApoC 1 and , particularly , ApoE ; there was no difference in ApoC 3 levels reflecting the hypertriglyceridemia common to both disorders . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Kinetic heterogeneity for apoA 1 , apoA 2 , apoB , apoC 2 and apoC 3 have been established . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The distributions of ApoA 1 and ApoA 2 varied among individuals , suggesting heterogeneity in the composition of HDL , and this was confirmed by the distributions of ApoC 3 , ApoD , and ApoE . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoE and apoC 3 released by Caco 2 cells were highly sialylated . mRNA species for apoA 1 , apoC 3 , and apoE , but not apoA 4 were identified by Northern blot analysis . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Results showed that patients with GSD 1 have a unique apolipoprotein profile characterized by normal or slightly decreased levels of ApoA 1 and ApoA 2 , reduced concentrations of ApoD , and significantly increased levels of ApoC 1 and ApoC 2 ( p less than 0 . 01 ) and ApoB , ApoC 3 , and ApoE ( p less than 0 . 0001 ) in comparison with age and sex matched normolipidemic controls . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In the case of the Apo AI variants , the concomitant deficiency of Apo AI and Apo CIII leads to severe clinical atherosclerosis . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Of these , all had apoA 1 levels more than one standard deviation below the normal mean , and 37 . 5 % had a similar decrease in apoC 3 values . ^^^ Mean ( + / SD ) plasma HDL cholesterol , apoA 1 , and apoC 3 values ( mg / dl ) in heterozygotes were 54 . 0 % , 62 . 4 % , and 79 . 2 % of normal , respectively . ^^^ Utilizing DNA isolated from two obligate heterozygotes , no abnormalities in the apoA 1 or apoC 3 genes were detected by Southern blot analysis utilizing specific probes following restriction enzyme digestion . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoC 2 , apoC 3 , apoA 1 , apoA 2 , and 1 M NaCl had no effect on H TGL activity . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The major apolipoproteins include apoE , apoB , apoA 1 , apoA 2 , apoA 4 , apoC 1 , apoC 2 , and apoC 3 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
C . ) 209 , 497 499 ] , synthesize and secrete into the culture medium most of the major plasma apoproteins ( apoA 1 , apoA 2 , apoB , apoC 2 , apoC 3 , and apoE ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The known linkage of apoA 1 and apoC 3 also permitted the simultaneous assignment of the apoC 3 gene to the same region on chromosome 11 . ^^^ Comparison with previously established gene linkages on the mouse and human genome suggests that apoA 1 + apoC 3 may be linked to the esterase A 4 and uroporphyrinogen synthase genes which are present on the long arm of human chromosome 11 . ^^^ The localization of the apoA 1 + apoC 3 genes in the p 11 q 13 region of chromosome 11 represents a definitive chromosomal assignment of a human apolipoprotein gene , and will now enable more detailed analysis of the geneomic organization and linkages of the apolipoprotein genes . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
It can be used to screen for abnormalities in apoA 1 , apoA 2 , apoA 4 , apoC 2 , apoC 3 , apoD , apoE , and apoH . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes . ^^^ In addition , we present the DNA sequence of the intergenic region lying between the apo AI and the apo CIII genes . . ^^^ We present an analysis of the structure of the apo CIII gene and compare it to the gene for apolipoprotein AI . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Furthermore , the alteration of the apo AI gene seems to affect the expression of the apo CIII gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Lipoprotein classes isolated from the plasma of two patients with apolipoprotein AI ( apo AI ) and apolipoprotein CIII ( apo CIII ) deficiency were characterized and compared with those of healthy , age and sex matched controls . ^^^ The simultaneous deficiency of apo AI and apo CIII suggests a dual defect in lipoprotein metabolism : one in triglyceride rich lipoproteins and the other in HDL . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Plasma lipids and 6 plasma apolipoproteins ( apoA 1 , apoA 2 , apoB , apoC 1 , apoC 2 and apoC 3 ) were studied in 23 patients with nephrotic syndrome . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The plasma concentrations of ApoB declined from base line values of 80 . 3 mg / dl to 54 . 6 mg ( mono ) , 51 . 8 mg ( poly ) , and 59 . 6 mg ( sat ) while Apo CIII and Apo AI did not show any changes . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
HDL C was related positively with apoA 1 , HDL apoA 1 , C 3 and negatively with apoC 3 , E , LDL apoB 100 and VLDL apoB 100 , C 2 , C 3 , E . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Second , transgenic mice model provides relevant insights into lipoprotein metabolism : the structural role of human apo AII , the effect of apo AI on HDL subfractions distribution , the contribution of apo CIII to hypertriglyceridemia , and by contrast of apo E in the clearance of atherogenic TG rich lipoproteins , the role of CETP in the balance of LDL and HDL concentration and distribution . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Using a multivariate analysis , we found that ( 1 ) genotypes of APOB , PON , LPL , LDLR , and APOE were significantly associated with variation of plasma apo B related traits ; ( 2 ) genotypes of PON , LPL , and APOC 3 were significantly associated with variation in plasma triglycerides ; and ( 3 ) genotypes of VLDLR , APOC 3 , LDLR , and APOE were significantly associated with variation in plasma apo AI and HDL cholesterol . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The elements contained within this 260 bp apoC 3 domain are sufficient to direct a pattern of expression in villus associated enterocytes distributed along the duodenal to ileal axis that resembles that of mouse and human apoA 1 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The values of ten lipid parameters were determined : cholesterol ( TC ) , triglycerides ( TGs ) , apolipoprotein A 1 ( apo A 1 ) , apolipoprotein B ( apo B ) , apolipoprotein E ( apo E ) , total apolipoprotein CIII ( apo CIII ) , apolipoprotein CIII present in particles containing apo B ( apo CIII LpB ) or not ( apo CIII Lp non B ) , lipoparticles A 1 ( LpA 1 ) , and lipoprotein a ( Lp ( a ) ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Studies in transgenic mice show that CETP expression results in decreased levels of HDL cholesterol , but that the effects of CETP on HDL apolipoprotein A 1 ( apoA 1 ) content and size show important modulation by co expression with transgenes encoding human apoA 1 , apoC 3 and apoA 2 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
By using chemical cleavage mismatch analysis and the single strand conformation polymorphism technique , DNA fragments of the apo CIII gene , including the 5 ' flanking region and all the exons , were screened for sequence changes underlying the observed association between familial combined hyperlipidaemia ( FCHL ) and the apo AI CIII AIV gene cluster in affected individuals from eight FCHL families . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Linkage disequilibrium was observed between the mutation and the common alleles of two restriction fragment length polymorphisms , MspI and SstI located in the APOA 1 and APOC 3 genes , respectively , in the Japanese population . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The porcine apoA 1 gene is located adjacent to the apoC 3 gene , as in humans . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
After this treatment period , the drug group was characterized in comparison with the placebo group by significantly reduced levels of total cholesterol ( 33 % ) , triglycerides ( 30 % ) , very low density lipoprotein cholesterol ( 36 % ) , low density lipoprotein cholesterol ( 43 % ) , apoB ( 36 % ) , apoC 3 ( 18 % ) , and apoE ( 17 % ) and slightly but insignificantly increased levels of high density lipoprotein cholesterol ( 6 % ) and apoA 1 ( 1 % ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
NIDDM subjects also have altered apolipoprotein concentrations , including increased apoB , apoC 3 , and decreased apoA 1 ; in addition , apoE 2 may be over represented in diabetic populations . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
To investigate a possible modulation of the effects of CETP by apoA 2 , human CETP transgenic mice were cross bred with transgenic mice expressing human apoA 2 and , in some cases , human apoA 1 and apoC 3 ( with human like HDL and hypertriglyceridemia ) . ^^^ CETP expression resulted in reductions of HDL and increases in VLDL cholesteryl ester in mice expressing human apoA 2 , alone or in combination with apoA 1 and apoC 3 , indicating that apoA 2 does not inhibit the cholesteryl ester transfer activity of CETP . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
These genes include those encoding various apolipoproteins ( apo ) , including apoA 1 , apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , apoE , and apo ( a ) , cholesteryl ester transfer protein ( CETP ) , HDL binding protein , lipoprotein lipase , and the low density lipoprotein ( LDL ) receptor . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In FCH the X 2 minor allele of the AI CIII AIV gene cluster was associated with increased fasting plasma TG , apo CIII , apo AI , and NEFA concentrations and decreased postheparin lipolytic activities . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Both purified apoA 1 and apoC 3 showed single bands on SDS PAGE at molecular weights of 28183 and 9400 Daltons , respectively . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Enzyme linked immunoassays were used to quantify apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , apoE and apo B 100 in Lp [ a ] and autologous LDL isolated from three healthy males . ^^^ In contrast , the autologous LDL preparations contained relatively higher amounts of apoA 1 , apoA 2 , apoE , apoC 1 , apoC 2 and apoC 3 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The patients had significantly reduced level of Apo AI and ratio of Apo AI / Apo B 100 , and increased levels of Apo CII , Apo CIII . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We have previously reported in this sample of children that the two polymorphisms detected with restriction enzyme PvuII , with variable sites in the first intron of the apo CIII gene ( Pvu 2 CIII ) and the apo CIII AIV intergenic region ( Pvu 2 AIV ) , were associated with significant differences on plasma apo AI levels . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In obese rats fed chow , hepatic apoA 4 gene expression was more than twofold higher than in lean rats because of a post transcriptional mechanism . apoA 1 gene expression and apoC 3 mRNA levels , studied as controls , were similar in both groups . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 1 , apoA 2 , apoA 4 , apoB , apoC 3 , apoD , apoE , apoH , lecithin : cholesterol acyltransferase ( LCAT ) , cholesteryl ester transfer ( CET ) protein , proline rich protein , and a protein of Mr 59 , 000 were detected in the A IVLp . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Statistically significant decreases of serum apo AI , apo A 2 and increases of apo CIII , apo E were observed in neural degenerative diseases ; and , particularly , higher apo B and apo CII concentrations were observed in diabetic neuropathy . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
To study the expression of these Apo encoding genes in the developing swine , apoA 1 and apoC 3 cDNAs from a lambda gt 11 porcine liver cDNA library and apoC 3 from a porcine genomic DNA library were isolated and sequenced . ^^^ Developmentally , hepatic apoA 1 and apoC 3 mRNAs were expressed in livers of fetal , newborn , and suckling animals . ^^^ Intestinal apoA 1 and apoC 3 mRNAs , however , were detected only in postpartum animals . ^^^ Although intestinal apoA 1 mRNA expression continued into the adult , intestinal apoC 3 mRNA expression declined sharply after the newborn period . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In humans , apo AI is believed to play an important protective role in the pathogenesis of arteriosclerosis , whereas apo CIII might be involved in the development of hypertriglyceridemia . ^^^ In this report , the complete nucleotide sequences of the porcine apo AI and CIII genes are presented and we demonstrate , for the first time , apo CIII expression in the pig . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Displacement of apoA 1 by apoC 3 from the lipid emulsion surface , therefore , resulted in apparent deactivation of the LTP reaction . ^^^ ApoA 1 , A 2 , and E are more potent activators than apoC 3 for cholesteryl ester transfer . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Intestinal expression of the human apoA 1 gene in transgenic mice is controlled by a DNA region 3 ' to the gene in the promoter of the adjacent convergently transcribed apoC 3 gene . ^^^ In the current study , a 10 . 5 kb DNA construction containing the apoA 1 and the adjacent convergently transcribed apoC 3 genes , which extends from 300 bp 5 ' to the apoA 1 gene to 2 . 5 kb 5 ' to the apoC 3 gene , produced high levels of apoA 1 intestinal expression . ^^^ A similar DNA construction ending 1 . 4 kb 5 ' to the apoC 3 gene also allowed apoA 1 intestinal expression . ^^^ The DNA region from 0 . 2 to 1 . 4 kb 5 ' to the apoC 3 gene was then cloned 1 . 7 kb 3 ' to the apoA 1 gene in both orientations in the absence of apoC 3 gene sequences . ^^^ In summary , these in vivo experiments suggest that the intestinal control region for the apoA 1 gene is distinct from the liver control region , resides 3 ' to the gene in the promoter of the adjacent apoC 3 gene , and has some properties of a tissue specific enhancer . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
These abnormalities result in a characteristic decrease of the apoA 1 to apoC 3 ratio and anti atherogenic index apoA I / apoB . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Simvastatin at 200 mg / d significantly decreased the levels of TC ( 25 % ) , LDL C ( 27 % ) , lathosterol ( 40 % ) , apoB ( 22 % ) , apoC 3 ( 37 % ) , and apoE ( 24 % ) and modestly decreased the levels of HDL C ( 12 % ) and apoA 1 ( 11 % ) ( percent relative to the average pretreatment and posttreatment baseline values ) but did not affect the levels of TG , VLDL C , the lathosterol / TC ratio , or LCAT activity . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The Ter 447 allele had a lowering effect on triglycerides ( P < 0 . 01 ) , VLDL cholesterol ( P < 0 . 05 ) , apoC 3 ( P < 0 . 001 ) , LpE : B ( P < 0 . 01 ) , and LpCIII : B ( P < 0 . 05 ) , and a raising effect on apoA 1 levels ( P < 0 . 05 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The apoA 1 levels tended to be lower and as a consequence the apoA I / apoC 3 ratio , considered to represent the hallmark of the altered apolipoprotein profile in renal dyslipoproteinaemia , was markedly lower in NTG patients ( 8 . 7 versus 16 . 8 , P < 0 . 001 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Multivariate analysis showed that no parameter involving apoC 3 and apoE was more discriminatory than HDL cholesterol , cholesterol , and triglycerides or apoA 1 , apoB , and triglycerides between controls and MI subjects . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Three restriction enzyme polymorphisms , XmnI and MspI sites 5 ' of the apoA 1 gene and the SstI site in the 3 ' untranslated region of exon 4 of the apoC 3 gene , were examined . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Overweight boys had significantly higher levels of total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , atherogenic index ( AI ) , RLP cholesterol ( RLP C ) , apoA 1 , apoA 2 , apoB , apoC 2 , apoC 3 , apoE and the ratio of apoB to apoA 1 than non overweight boys . ^^^ Overweight girls had significantly higher levels of TC , LDL C , AI , remnant like lopoprotein cholesterol ( RLP C ) , apoA 2 , apoB , apoC 2 , apoC 3 , apoE and the ratio of apoB to apoA 1 than non overweight girls . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The levels of apo B , Apo AI levels and apo CIII / apo CII were similar in the hyperuricemic and controls . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Transient transfection assays have shown that the distal apoC 3 promoter segments that contain the regulatory elements F to J enhance the strength of the tandemly linked proximal apoA 1 promoter 5 to 13 fold in hepatic ( HepG 2 ) cells . ^^^ The apoC 3 enhancer can also restore the activity of the proximal apoA 1 and apoB promoters that have been inactivated by mutations in CCAAT / enhancers binding protein binding sites , indicating that C / EBP may not participate in the synergistic activation of the promoter / enhancer cluster . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoE containing lipoproteins in the HDL size range had a particle size ranging from 9 to 18 . 5 nm in diameter and could be characterized as having either gamma , pre beta 1 , pre beta 2 or alpha electrophoretic mobility ( designated gamma LpE , pre beta 1 LpE , pre beta2LpE , and alpha LpE respectively ) . gamma LpE and a substantial proportion of pre beta 1 and pre beta 2 LpE did not co migrate with apoA 1 , apoA 2 , apoC 3 , or apoB 100 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Lipid Res . , 1996 , 36 : 136 147 ) we have studied three restriction enzyme polymorphisms : XmnI , and MspI sites 5 ' of the apo AI gene and SstI site in the 3 ' untranslated region of exon 4 of the apo CIII gene in 18 FCH pedigrees , including 18 probands , 178 hyperlipidemic relatives , 210 normolipidemic relatives , and 176 spouses . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
METHODS : Some of these variants are fairly common genomic variants in the promoter regions for candidate genes in lipoprotein metabolism , such as APOA 1 , APOC 3 , LPA , and LPL . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We have examined the ability of individual human HDL apolipoproteins ( apoA 1 , apoA 2 , and apoC 3 ) reconstituted into phospholipid / unesterified cholesterol complexes to bind to murine SR BI ( mSR BI ) expressed in stably transfected cultured cells . ^^^ Thus , all three of the HDL apolipoproteins ( apoA 1 , apoA 2 , and apoC 3 ) tested can directly mediate binding to mSR BI , and this multiligand apolipoprotein receptor may be responsible for at least some of the multilipoprotein and apolipoprotein binding activity previously observed in cells and tissues . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
While atorvastatin also resulted in clinically significant reductions in triglyceride , VLDL cholesterol , apoB in VLDL , triglyceride in VLDL , and apoC 3 and significant increases in HDL cholesterol and apoA 1 levels , fenofibrate was more effective than atorvastatin in altering all these parameters . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
These results add new evidence that common regulatory elements for the expression of the apoA 1 , apoC 3 and apoA 4 genes are interspersed throughout the cluster . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
However , the associations could also have resulted from linkage disequilibrium with other functional variants in APOC 3 or the closely linked APOA 1 and / or APOA 4 genes . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The polymorphic sites were located in the promoter region of the apo AI gene ( G to A substitution , MspI ) , in the 3 ' flanking region of the apo AI gene ( PstI ) , in the 3 ' noncoding region of the apo CIII gene ( SstI ) , in the first intron of the apo CIII gene ( PvuIIa ) , in the intergenic region of the apo CIII and apo AIV genes ( PvuIIb ) , and in the second intron of the apo AIV gene ( XbaI ) , respectively . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The levels of apo B , Apo AI levels and apo CIII / apo CII were similar in the hyperuricaemic and controls . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The rare allele of the apo AI MspI restriction site polymorphic variant was also found more frequently in the upper tertiles for apo CIII , apo E , and plasma triglyceride / HDL ratios ( P < 0 . 04 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : Patients with DN had a plasma lipid and apolipoprotein profile characteristic of renal dyslipoproteinaemia with increased concentrations of triglycerides and cholesterol , reduced levels of apoA 1 and apoA 2 and increased levels of apoB , apoC 2 , apoC 3 and apoE . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The main abnormalities found are : increased levels of triglycerides , VLDL Tg , LDL Tg , VLDL Cholesterol , Apo B and Apo CIII , with decreased values of HDL Cholesterol and Apo AI . ^^^ As there is a strong correlation between control and the degree of lipid changes , even with normal levels of cholesterol and triglycerides , measurements of Apo AI , Apo B 100 and Apo CIII seem to be good and reliable indicators of glycemic control in diabetic children , and a factor with high predictive value for the evaluation of cardiovascular risk in adult patients . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Previous studies have shown that the 780 / 520 enhancer region of the apoC 3 gene directs the expression of the apoA 1 gene in both small intestinal villi and crypts , implying that other unidentified elements are necessary for a normal intestinal pattern of apoA 1 gene expression . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We approached the subject by studying three genetic variants of this region : a C 1100 T transition in exon 3 of the apoC 3 gene , a G 3206 T transversion in exon 4 of the apoC 3 gene , and a G 75 A substitution in the promoter region of the apoA 1 gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In transgenic mice , a distal enhancer located between the apoA 4 and apoC 3 genes is additionally necessary for tissue specific expression of apoA 1 in liver and intestine . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Finally , P . pinaster seed oil treatment was associated with a small decrease of liver apoC 3 ( P < 0 . 02 ) but not in apoE , apoA 1 , or apoA 2 mRNA levels . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Other loci , including APOA 4 , APOA 1 , APOB , APOC 3 , LPL and CETP have also been found to account for some of the variability in the fasting and fed states . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Combinations of haplotypes , based on three restriction enzyme polymorphisms : XmnI and MspI sites , 5 ' of the start site of the apoA 1 gene and SstI polymorphism in the 3 ' untranslated region of exon 4 of the apoC 3 gene , were analyzed to characterize their effect on the expression of severe hyperlipidemia . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Significant correlations were also observed between levels of MDA , apoB / apoA 1 , apoE / apoC 3 , and Ccr and age , as well as between apoE levels and UP and age . ^^^ The levels of apoA 1 and apoA I / apoA 2 ratio were significantly correlated with UP alone , whereas the apoC II / apoC 3 ratio was significantly correlated with Ccr alone . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
No significant differences in plasma apoA 1 and apoC 3 as well as in apoA 1 , C 3 containing lipoprotein particles ( including the apoC 3 ratio ) were observed between the drugs , neither before nor after each active treatment . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The goal of the present study was to compare the allele frequency of four polymorphisms at the apo A 1 C 3 A 4 cluster gene locus ApoA 1 : XmnI and PstI ; ApoC 3 : SstI ; ApoA 4 : XbaI between male patients who had had a myocardial infarction ( n= 614 ) and matched controls ( n = 764 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The effect of serum on apolipoprotein secretion was more pronounced for apo CIII whereas other apolipoproteins ( apo E , apo B , apo AII and apo AI ) were affected to a lesser extent . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The results demonstrated that owing to the intake of high cholestrol diet with the passage of time , the increased concentrations of serum VLDL C , apoB , apoC 2 and apoC 3 possibly caused an enhanced secretion of biliary cholesterol into bile ; that the decreased serum apoA 1 level might reduce the secretion of anti nucleating factor into bile . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : Basal apoA 4 gene expression was increased in fatty rats of both strains , whereas apoA 1 and apoC 3 gene expression differed between Wistar and Zucker fatty rats : apoA 1 gene transcription was reduced to half and apoC 3 mRNA was increased two fold in Wistar fatty , but not in Zucker fatty rats vs lean controls . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
At the basal untreated level , RXRalpha deficiency resulted in marked induction of apolipoprotein A 1 and C 3 ( apoA 1 and apoC 3 ) mRNA levels and serum cholesterol and triglyceride levels , which was not found in PPARalpha null mice . ^^^ In contrast , the basal cytochrome P 450 4A1 , liver fatty acid binding protein , and apoA 1 and apoC 3 mRNA levels were significantly altered in the mutant mouse livers , but the regulatory effect of Wy 14 , 643 on expression of those genes remained the same . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Overexpression of apoC 3 in mice causes hypertriglyceridemia and induces atherogenesis , whereas overexpression of apoA 1 or apoA 4 increases cholesterol in plasma high density lipoprotein ( HDL ) and protects against atherosclerosis . ^^^ In the pooled data , plasma concentrations were 257+ / 9 , 7 . 1+ / 0 . 5 , and 1 . 0+ / 0 . 2 mg / dL for human apoA 1 , apoC 3 , and apoA 4 , respectively ( mean+ / SEM ) . ^^^ Human apoA 1 and apoC 3 concentrations were positively correlated , suggesting that they are coregulated . ^^^ Plasma triglyceride and cholesterol concentrations were correlated positively with human apoC 3 concentration , and HDL cholesterol was correlated with apoA 1 concentration . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In contrast to apoC 3 , apoA 1 and haptoglobin , the majority of apoSAA was found in the HDL fraction , as observed in normolipidemic calves . ^^^ Increased concentrations in the CM of apoC 3 and apoA 1 suggest that the two apolipoproteins may be involved in the pathogenesis of calf hyperlipidemia . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : Total Cholesterol ( TC ) , Triglycerin ( TG ) , high density lipoprotein ( HDL C ) , Apolipoprotein AI ( Apo AI ) , Apolipoprotein AII ( Apo AII ) , Apolipoprotein B ( Apo B ) , Apolipoprotein CII ( Apo CII ) , Apolipoprotein CIII ( Apo CIII ) , Lipoprotein ( a ) [ Lp ( a ) ] increased significantly ( P < 0 . 05 ) , while ApoB / AI , ApoCII / CIII decreased significantly ( P < 0 . 05 ) in conjugated estrogen group . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
No significant difference was observed in TG , apoA 1 , apoC 2 , and apoC 3 levels among the apoE 2 , E 3 and E 4 groups ( P > 0 . 05 ) . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
METHODS AND PROCEDURES : The SstI restriction fragment length polymorphisms ( RFLP ) in the 3 ' untranslated region of the apo CIII gene and the MspI RFLP in the third intron of the apo AI gene were scored and the lipid concentrations were ascertained using standard methodologies . t tests were used to compare lipid levels between sexes and between populations , and multivariate ANOVA was used to detect if the two RFLPs had an effect on any of the lipid concentrations . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : Among the 2185 subjects examined , the mean serum value for apoA 1 was 1 . 42 + / 0 . 20 g / l , for apoA 2 was 0 . 30 + / 0 . 05 g / l , for apoB was 0 . 87 + / 0 . 18 g / l , for apoC 2 was 29 + / 13 mg / l , for apoC 3 was 75 + / 20 mg / l , and for apoE was 36 + / 9 mg / l . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Linkage and association of the apo AI CIII 4 gene region to familial combined hyperlipidemia ( FCHL ) was reported previously , based on the presence of genetic variants in the apo CIII and apo AI gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In nonsmokers only , the APOC 3 1100C allele in women was related to lower apoB related traits concentrations , and in men to higher apoA 1 and HDL cholesterol concentrations . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We hypothesize that the region between the apo AI and apo CIII genes may harbour functional mutations that might be in linkage disequilibrium with the already identified SstI and MspI polymorphisms , and provide an alternative explanation for the observed relationship . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Among plasma TG , TC , HDL C , apo AI , apo AII , apo B 100 , apo CII , Apo CIII and apoE , only HDL C and apo AI were significantly different among the three genotypes +1075A / A , +1075A / C and +1075C / C in men ( P=0 . 029 and 0 . 032 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
As a mechanism for its effects on plasma lipid levels and atherosclerosis , recent studies reported that fibrates activates various genes involved in metabolism of remnants and HDL such as lipoprotein lipase , apo AI , apo AII , and apo CIII genes through the interaction with PPAR alpha , lowering atherogenic lipoproteins and elevating anti atherogenic lipoproteins . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We measured plasma lipids , insulin , apoA 1 , apoB , and apoC 3 and assessed three polymorphisms in the apoC 3 gene , namely , T 455C in the IRE promoter region , C1100T in exon 3 , and Sst 1 polymorphic site ( S1 / S2 ) in the 3 ' untranslated region . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The study of APOA 1 , APOC 3 and APOA 4 variability in healthy ageing people reveals another paradox in the oldest old subjects . ^^^ The genes coding for apolipoprotein A 1 ( APOA 1 ) , apolipoprotein C 3 ( APOC 3 ) and apolipoprotein A 4 ( APOA 4 ) are tandemly organised within a short region on chromosome 11q23 q 24 . ^^^ The aim of this study was to describe possible modifications of the APOA 1 , APOC 3 , and APOA 4 gene pool by cross sectional studies carried out in a healthy ageing population whose ages ranged from 18 to 109 years ( 800 subjects , 327 males and 473 females , free of clinically manifested disease , and with emato chemical parameters in the norm ) . ^^^ APOA 1 MspI RFLP ( 75 nt from the transcription starting site ) , APOC 3 SstI RFLP ( 3 ' UTR , 3238 nt ) , and APOA 4 HincII RFLP ( Asp127 / Ser127 ) were analysed according to age and sex . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Serum TG , apoC 2 and apoC 3 were highly increased in normotensive pregnant women by 3 . 5 , 2 . 4 and 2 . 8 times respectively , when compared with those in non pregnant ones ( P < 0 . 001 ) ; serum TC , nHDL C and apoAI , B 100 and E were also increased in normotensive pregnant women by 21 % , 33 % , 55 % , 79 % and 77 % respectively , when compared with those in non pregnant ones ( P < 0 . 001 ) . ^^^ Serum TG , apoC 2 and apoC 3 were highly increased in PIH patients by 2 . 3 , 4 . 0 and 2 . 8 times respectively , when compared with those in non pregnant ones ( P < 0 . 001 ) ; serum TC , nHDL C and apoAI , B 100 and E were also increased in PIH patients by 27 % , 26 % , 52 % , 90 % and 67 % respectively , when compared with those in non pregnant ones ( P < 0 . 001 ) TG / HDL C in PIH patients was also significantly higher than that in non pregnant ones ( P < 0 . 01 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In chylomicron free serum , the density of bound apoA 1 at small emulsion surfaces was about three fold greater than large emulsion surfaces , but the binding densities of apoC 2 , apoC 3 and apoE were less for small emulsion surfaces than for large ones , suggesting that apoA 1 preferentially binds to small particles and displaces other exchangeable apolipoproteins from particle surfaces . ^^^ These results indicate that , in addition to the well known inhibitory effects of apoC 3 and apoE , apoA 1 in plasma regulates the lipolysis of triglyceride ( TG ) rich emulsions and lipoproteins in a size dependent manner . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Plasma turnover of HDL apoC 1 , apoC 3 , and apoE in humans : in vivo evidence for a link between HDL apoC 3 and apoA 1 metabolism . ^^^ In order to better define the role of HDL apolipoproteins in determining plasma HDL concentrations , the aims of the present study were : a ) to compare the in vivo rate of plasma turnover of HDL apolipoproteins [ i . e . , apolipoprotein A 1 ( apoA 1 ) , apoC 1 , apoC 3 , and apoE ] , and b ) to investigate to what extent these metabolic parameters are related to plasma HDL levels . ^^^ Plasma HDL apolipoprotein levels were 41 . 8 + / 1 . 5 , 9 . 7 + / 0 . 5 , 4 . 9 + / 0 . 5 , and 0 . 7 + / 0 . 1 micromol / l for apoA 1 , apoC 1 , apoC 3 and apoE . ^^^ HDL apoC 3 TR was positively correlated with levels of HDL apoC 3 ( r = 0 . 73 , P < 0 . 01 ) , and with those of HDL cholesterol and apoA 1 ( r = 0 . 54 and r = 0 . 53 , P < 0 . 05 , respectively ) . ^^^ HDL apoC 3 TR was in turn related to HDL apoA 1 RT ( r = 0 . 51 , P < 0 . 05 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Fibrate therapy has been reported to decrease apo CIII levels ( a powerful inhibitor of lipoprotein lipase ) and increase apo AI levels , as well as to increase lipoprotein lipase activity . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Genetic study of common variants at the Apo E , Apo AI , Apo CIII , Apo B , lipoprotein lipase ( LPL ) and hepatic lipase ( LIPC ) genes and coronary artery disease ( CAD ) : variation in LIPC gene associates with clinical outcomes in patients with established CAD . ^^^ These genetic variables were : apolipoprotein E ( Apo E ) , Apo AI , Apo CIII , Apo B , lipoprotein lipase ( LPL ) and the hepatic lipase ( LIPC ) genes . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.65113443
These findings indicate that the polymorphism in the region between the apolipoprotein A 1 and apolipoprotein C 3 genes may be a useful marker for the risk of premature coronary artery disease and familial hypoalphalipoproteinemia . . 0.65113443^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 4 is a protein constituent of HDL particles ; the gene coding for it is a member of the ApoA 1 ApoC 3 ApoA 4 cluster . ^^^ The latter diets also led to increases in hepatic ApoA 1 , ApoA 4 and ApoC 3 mRNA levels , more so with the sunflower oil rich diet . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In conclusion , our studies with human apoAI / CIII / AIV / AV gene cluster transgenic models showed that the apoCIII enhancer regulated expression of apoAI , apo CIII , and apoAIV but not apoAV in vivo and showed the influences of expression of the entire cluster on lipid metabolism . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The multivariate model included 512 men with coronary artery disease from the REGRESS study who were completely genotyped for eight polymorphisms selected in the univariate procedure ( ie , APOA 1 G ( 75 ) A , ABCA 1 C ( 477 ) T , ABCA 1 G1051A , APOC 3 T3206G , APOE Arg158Cys , LIPC C ( 514 ) T , LPL Asn291Ser and LPL Ser447Stop ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 4 and apoE were decreased to approximately 10 % of control in HDL isolated from rats with HN , whereas apoA 2 , apoC 2 , and apoC 3 were each significantly increased relative to apoA 1 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In addition to being the first to report on the presence of apoA 2 in pig plasma , we also obtained values for the molecular masses of apoA 1 , apoC 3 , apoD and serum amyloid A protein . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
A prospective study of the APOA 1 XmnI and APOC 3 SstI polymorphisms in the APOA1 / C3 / A4 gene cluster and risk of incident myocardial infarction in men . ^^^ METHODS : In a prospective nested case control study of 385 incident cases of MI and 373 age and smoking matched controls from the Physicians ' Health Study , we examined the relationship between 2 common single nucleotide polymorphisms ( APOA 1 XmnI and APOC 3 SstI ) in the APOA1 / C3 / A4 gene cluster and haplotypes defined by these SNPs and risk of incident MI . ^^^ RESULTS : No significant differences in allele or genotype frequency for the APOA 1 XmnI and APOC 3 SstI polymorphisms were detected between cases and controls . ^^^ After adjusting for non lipid coronary risk factors , the relative risks for incident MI were 1 . 00 ( 95 % CI 0 . 68 1 . 47 ) for men carrying the X 2 allele compared with those homozygous for the X 1 allele in the APOA 1 XmnI site and 1 . 07 ( 95 % CI 0 . 69 1 . 64 ) for men carrying the S 2 versus those homozygous for the S 1 allele in the APOC 3 SstI site . ^^^ Moreover , we did not observe any effect modification by HDL or TG levels for the associations of these APOA 1 and APOC 3 genotypes with MI risk . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
All subjects underwent phenotyping after an oral glucose tolerance test ( 75 g ) ( WHO 1998 criteria ) and the XmnI and MspI polymorphisms of Apo AI and the SstI polymorphism of Apo CIII were genotyped . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Compared with the G / G carriers , G / A and A / A carriers had significantly higher plasma concentrations of TG , apoC 2 , apoC 3 , apoA 1 contents of prebeta ( 1 ) HDL , HDL ( 3a ) and TG / HDL C ratio . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Therefore , in the present investigation we studied the distribution of APOA 1 75 G > A , +83 C > T , APOC 3 482 C > T , 455 T > C and 3238 C > G , and APOA 4 Q360H and T347S polymorphisms and their influence on plasma lipoprotein levels in children from a Brazilian northeastern admixed population . ^^^ Strong linkage disequilibrium was detected between polymorphisms at the APOA 1 , APOC 3 and APOA 4 loci in this admixed population sample . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The sdLDLs of both types of patients were enriched in apolipoprotein C 3 ( apoC 3 ) and were depleted of apoC 1 , apoA 1 , and apoE compared with matched healthy controls with the A phenotype . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
This study compares the frequencies of seven APO ( APOA 1 75 bp , APOA 1 +83 bp , APOB Ins / Del , APOB XbaI , APOC 3 SstI , and APOE ) and LPL loci in Mennonite populations from Kansas and Nebraska . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Lipid and apolipoproteins ( ApoAI , ApoB , Apo CIII , ApoE ) disturbance in hemodialysis ( HD ) and renal transplant ( Tx ) patients . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Fenofibrate stimulated liver fatty acid beta oxidation , increased the transcriptional expression of carnitine palmitoyltransferase 1 and phospholipid transfer protein , and decreased expression of apoA 1 and apoC 3 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The effect of fibrates on the metabolism of triglyceride rich lipoproteins is due to a PPAR alpha dependent stimulation of lipoprotein lipase and of apolipoprotein ( apo ) A 5 and to an inhibition of apoC 3 expression , whereas the increase in plasma HDL cholesterol depends partly on an overexpression of apoA 1 and apoA 2 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
MS revealed that these spots comprised apolipoprotein A 1 ( apoA 1 ) , apolipoprotein C 3 ( apoC 3 ) , vitamin D binding protein , alpha 1 antitrypsin and proteasome subunit alpha type 1 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Mass spectrometry showed that the apoM containing lipoproteins also contained apoJ , apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , paraoxonase 1 , and apoB . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Quantitative analyses of hepatic mRNA levels revealed that IHE administration resulted in up regulation of mRNA for acyl CoA oxidase , acyl CoA synthetase , hydroxymethylglutaryl CoA synthetase , lipoprotein lipase and fatty acid transport protein , and down regulation of mRNA for Apo CIII and Apo AI . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The molecular masses of apoA 1 , proapoA 1 , apoA 2 , proapoA 2 , apoC 1 and apoC 3 were obtained . ^^^ Comparing the values obtained for the two strains , differences in the molecular masses of apoA 1 , apoA 2 and apoC 3 were observed . ^^^ Further analyses by tandem mass spectrometry ( MSMS ) done on the tryptic digests of apolipoproteins separated by reverse phase chromatography enabled us to confirm sequence differences between the two strains , to verify selected apoA 1 sequences that had been entered into the GenBank and to identify which methionines in apoA 1 , apoC 3 and apoE had been converted to methionine sulfoxides . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Antagonism between apolipoprotein AI regulatory protein 1 , Ear3 / COUP TF , and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Unlabeled purified apolipoprotein CIII 1 , but apoAI , CI , CII , could effectively inhibit 125I labeled VLDL binding to NPC . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
A dramatic increase in apolipoprotein serum amyloid A up to a mean plasma level of 0 . 764 g / l was accompanied by a considerable decrease in apolipoprotein A 1 , apolipoprotein A 2 and apolipoprotein C 3 concentrations . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
A DNA sequence polymorphism , revealed by digestion of human DNA with the restriction endonuclease Sst 1 and hybridization with an apolipoprotein A 1 complementary DNA clone , has been shown to be located in or close to the 3 ' noncoding region of the apolipoprotein C 3 gene . ^^^ Furthermore , no alteration of high density lipoprotein or apolipoprotein A 1 and apolipoprotein C 3 phenotypes was observed in individuals with or without the polymorphism . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Nor were there any significant differences between the two groups in plasma concentrations of apolipoprotein A 1 , apolipoprotein B , apolipoprotein C 3 , and apolipoprotein E measured by electroimmunoassay . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Both groups of patients were characterized by reduced levels of apolipoprotein A 1 ( P less than or equal to 0 . 04 ) and increased levels of apolipoprotein C 3 ( P less than or equal to 0 . 002 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Apolipoprotein A 1 and apolipoprotein C 3 ( heparin supernate ) were not significantly changed . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
These markers are located at 2500 and 78 bp from the transcription start site of apolipoprotein AI gene ( XmnI and MspI , respectively ) , and in the 3 ' untranslated region of apolipoprotein CIII gene ( SstI ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Analysis of genomic DNA from the subjects revealed five polymorphic sites which defined two haplotypes in the intestinal enhancer region of the apoAI gene located upstream of the apolipoprotein CIII gene transcriptional start site ( + 1 ) : ( 641 C to A , 630 G to A , 625 T to deletion , 482 C to T , and 455 T to C ) . ^^^ Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The effect of fibrates on the metabolism of triglyceride rich lipoproteins is due to a PPAR alpha dependent stimulation of lipoprotein lipase and an inhibition of apolipoprotein C 3 expressions , whereas the increase in plasma HDL cholesterol depends on an overexpression of apolipoprotein A 1 and apolipoprotein A 2 . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
A hormone response element in the human apolipoprotein CIII ( ApoCIII ) enhancer is essential for intestinal expression of the ApoA 1 and ApoCIII genes and contributes to the hepatic expression of the two linked genes in transgenic mice . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
With regard to the common mutations , plasma triacylglycerol levels were related to the HindIII variants of lipoprotein lipase ( P < 0 . 05 ) , to the apolipoprotein CIII variant ( C3175G in exon 4 ) and to the apolipoprotein AI XmnI polymorphisms ( P < 0 . 05 and P < 0 . 02 respectively ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Obtained data strongly suggest that decreases in serum concentrations of apolipoprotein B 100 , apolipoprotein A 1 and apolipoprotein C 3 , a reduction in activity of lecithin : cholesterol acyltransferase and induction of haptoglobin and serum amyloid A are intimately related to the development of fatty liver and fatty liver related diseases . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
A number of studies have examined the potential role in longevity of other genes involved in vascular risk , haemostasis , and blood pressure regulation [ methyltetrahydrofolatereductase ( MTHFR ) , apolipoprotein A 1 ( APOA 1 ) , apolipoprotein C 3 ( APOC 3 ) , apolipoprotein A 4 ( APOA 4 ) , paraoxonase 1 ( PON 1 ) , plasminogen activator inhibitor type 1 ( PAI 1 ) ] , with contrasting results . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Polymorphisms were studied by amplification and RFLP in all subjects , using XmnI and MspI in the apolipoprotein AI gene and SstI in the apolipoprotein CIII gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
However , only rosuvastatin treatment significantly ( p < 0 . 05 to < 0 . 001 ) reduced fasting low density lipoprotein cholesterol , apolipoprotein B 100 , apolipoprotein C 3 , apolipoprotein C 3 : B particles , the apolipoprotein B 100 : apolipoprotein A 1 ratio , and increased apolipoprotein A 1 ( p < 0 . 05 ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Previous studies have shown that RORalpha regulates transcription of the murine Apolipoprotein AI gene and human Apolipoprotein CIII genes . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
OBJECTIVE : The apolipoprotein AI CIII AIV cluster has been associated with the response to a urate lowering diet , and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Especially high sensitivity and resolution were obtained in the region < 30 kDa , where multiple isoforms of apolipoprotein A 1 , apolipoprotein A 2 , apolipoprotein C 1 , apolipoprotein C 2 , apolipoprotein C 3 , and transthyretin could be assigned . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The profile of differentially expressed protein spots between patients and controls revealed proapolipoprotein A 1 , transferrin , and hemoglobin as up regulated and three spots , apolipoprotein A 1 , apolipoprotein C 3 , and haptoglobin alpha 2 as down regulated in patients . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : In the overall analysis , fenofibrate treatment resulted in significant ( p < 0 . 05 ) changes versus placebo in TG ( 36 . 6 % ) , non HDL C ( 7 . 5 % ) , very low density lipoprotein C ( 32 . 7 % ) , LDL C ( 15 . 0 % ) , HDL C ( 14 . 0 % ) , remnant lipoprotein C ( 35 . 1 % ) , apolipoprotein B ( 6 . 0 % ) , apolipoprotein A 1 ( 5 . 3 % ) , and apolipoprotein C 3 29 . 7 % ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The relative abundances of apoAI in liver , intestine , brain and kidney tissues are 100 % , 212 % , 170 % and 224 % , respectively , those of apoCII are 100 % , 61 % , 163 % and 214 % ; and those of apoCIII 100 % , 65 % , 70 % and 73 % , respectively . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The results revealed that total triglyceride , cholesterol , LDL , VLDL , and semi quantity of ApoCII , ApoCIII were significantly increased , and HDL , ApoAI ApoAI / ApoB rate , semiquantify of ApoCI were significantly reduced in non dialysis patients and patients on hemodialysis ; VLDL and Ccr were closely negative related in non dialysis patients . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Secretion of lipid poor nascent human apolipoprotein apoAI , apoCIII , and apoE by cell clones expressing the corresponding genes . ^^^ The human apolipoprotein apoAI , apoCIII , and apoE genes were placed under the control of the mouse metallothionein 1 promoter in a bovine papilloma virus vector that also contained the human metallothionein 1A gene . ^^^ Individual cell clones expressing apoAI , apoCIII , or apoE genes were used further to study the isoprotein composition and the flotation properties of the corresponding nascent apolipoproteins . ^^^ It was found that the lipoproteins secreted by cell clones expressing the apoAI , apoCIII , and apoE genes consisted of the proapoAI disialylated form of apoCIII ( apoCIIIS 2 ) and mainly sialylated forms of apoE . ^^^ Separation of the secreted apolipoproteins by density gradient ultracentrifugation resulted in limited flotation of nascent apoAI , apoE and apoCIII in the high density lipoprotein ( HDL ) fraction . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The alleles identified by the apoCIII Sst 1 and apoAI Msp 1 polymorphisms are in linkage disequilibrium . ^^^ The results of the present study suggest that both the apoCIII Sst 1 and apoAI Msp 1 polymorphisms may be a useful genetic marker for the analysis of apoAI CIII gene complex and the haplotype S 1 M2 may be a useful linkage marker for the putative atherogenic gene in Chinese . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The protein that binds to the sequence between 86 to 61 , called AF 1 , was characterized and also shown to interact with the apoCIII , apoA 1 , and apoCII promoters . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Footprinting analysis showed that purified NF BA 1 binds to the regulatory regions of apoCIII ( 87 to 63 ) , apoAII ( 740 to 719 ) , and apoAI ( 212 to 191 ) genes and may be involved in the regulation of their expression . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The gene coding for the human apoAIV is closely linked with the genes coding for apolipoproteins AI ( apoAI ) and CIII ( apoCIII ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The genes for two of the proteins of the plasma lipid transport system , apolipoprotein AI ( apoAI ) and CIII ( apoCIII ) are closely linked in the human genome . ^^^ These results indicate that apoAI , apoCIII , and apoAIV genes are closely linked in the human genome and suggest that all three of them are derived from a common ancestral precursor . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Narrow film strips from the IEF separation of HDL 2 and HDL 3 were interfaced with various agarose plates containing antisera against apolipoproteins apoAI , apoAII and apoCIII either alone or in combination , to provide two dimensional IEF immunoelectrophoresis patterns . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The human apoAI , apoCIII , and apoAIV genes are tandemly organized within a 15 kb DNA segment and are expressed predominantly in the liver and intestine . ^^^ A third 0 . 6 kb DNA fragment in the apoCIII gene promoter region , approximately 5 kb down stream from the human apoAI gene , enhances transcription mediated by either of these two tissue specific apoAI promoters . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The polymorphic sites were the SstI site in the apoCIII 3 ' untranslated region , whose presence has previously been shown to be associated with hypertriglyceridemia ( HTG ) in Caucasians , and the MspI site in the third intron of the apoAI gene . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Using genomic hybridization techniques , three polymorphic restriction sites were identified at this locus : the PstI at the 3 ' end of the apoAI gene , the SacI at the 3 ' non coding region of the apoCIII gene and the PvuII at the intergenic region between the apoCIII AIV genes . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Apolipoprotein E ( apoE ) , but not apoAI or apoCIII , suppresses mitogen activated T lymphocyte proliferation , independent of the type of activation signal . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
We applied restriction fragment length polymorphisms ( RFLPs ) for apolipoprotein ( apoAI , apoCIII , apoAIV , apoCI , and apoB ) genes to analyze differences between Japanese and Caucasian in allele frequencies as well as those between normal Japanese subjects and patients with coronary artery disease confirmed with coronary arteriography . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In both groups , plasma lipid variables were measured , including total cholesterol , triglycerides , high density lipoprotein cholesterol ( HDL C ) low density lipoprotein cholesterol , apolipoprotein ( apo ) AI , apoB , apoAI containing lipoprotein particles without apoAII ( LpAI ) and with apoAII , and apoB containing lipoprotein particles with apoE and with apoCIII . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
In addition HNF 1 also repressed the activity of HNF 4 dependent ApoCIII and ApoAI promoters . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The effects of polymorphisms in the lipoprotein lipase ( LPL ) gene ( HindIII and S447X ) and in the apolipoprotein ( apo ) AI CIII gene cluster ( G75A and C1100T ) on levels of fasting plasma triglycerides , apoCIII , high density lipoprotein cholesterol ( HDL C ) , and apoAI were examined in 315 healthy men and women from Iceland . ^^^ The H allele was generally associated with slightly lower levels of apoCIII , with a lowering effect on triglycerides only in smokers and with a raising effect on ApoAI in non smoking and smoking men and in non smoking women . ^^^ In the non smoking men , nonlinear additive effects were observed with combinations of genotypes at the LPL and apoAI CIII loci , with the HDL C and apoAI raising effect associated with the A 75 allele and H allele seen only in those men with both alleles , and the apoCIII raising effect associated with the H+ and T alleles seen only in those with both alleles . ^^^ Thus , variations at both of the LPL and apoAI apoCIII loci influence levels of triglycerides , apoCIII , HDL C , and apoAI , but these effects are strongly modulated by smoking and are different between men and women . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Plasma levels of total cholesterol ( TC ) , triglyceride ( TG ) , high density lipoprotein ( HDL ) C , apoAI , apoB , apoCII , apoCIII , and apoE were 200mg / dL , 451 mg / dL , 31 mg / dL , 115 mg / dL , 99 mg / dL , 10 . 0 mg / dL , 22 . 2 mg / dL , and 12 . 0 mg / dL , respectively . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Plasma levels of total cholesterol ( T CHOL ) , triglyceride ( TG ) , beta lipoprotein ( beta LIPO ) , free fatty acid , phospholipid , free cholesterol , high density lipoprotein cholesterol , lipoprotein ( a ) [ Lp ( a ) ] , lipoproteins ( VLDL , LDL , HDL ) and apolipoproteins ( apoAI , apoAII , apoB , apoCII , apoCIII , apoE ) were determined . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Increased hepatic expression of mRNA for apoCIII and apoAI was associated with increased content of apoC ( and relative depletion of apoE ) in VLDL of fatty rats , and plasma apoAI was increased in fatty Zucker rats , primarily in the HDL fraction . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
There was no cross reactions between antibodies used and apoAI , apoAII , apoB , apoCI , apoCII and apoCIII . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
ApoA 1 is the main component of high density lipoprotein ( HDL ) , and apoCIII inhibits lipoprotein lipase activity . ^^^ Genetic variations in APOA 1 CIII may affect the function of apoA1 / apoCIII and plasma lipid / lipoprotein levels , and thus , the risk of developing atherosclerosis . ^^^ CONCLUSIONS : Analysis of the frequency distribution of six RSVs of the APOA 1 CIII gene complex in Taiwanese CAD patients and control subjects showed that the effect of genotype on plasma lipid levels was gender specific and that the apoCIII level was closely associated with plasma triglyceride level and body mass index . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The predialysis , HD , and CAPD patients had disturbances in the concentration of serum triglyceride ( TG ) , high density lipoprotein ( HDL ) cholesterol , apolipoprotein AI ( apoAI ) , total apoCIII , apoCIII present in the particles without apoB ( apoCIII non B ) , and Lp ( a ) and HDL cholesterol , low density lipoprotein ( LDL ) cholesterol / HDL cholesterol , HDL cholesterol / apoAI , apoAI / apoB , and apoAI / apoCIII ratios . ^^^ The patients after transplantation demonstrated normalization of lipid and lipoprotein parameters and lipoprotein ratios except serum levels of TG , total apoCIII , apoCIII non B and the apoAI / apoCIII ratio . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The SP 1 sites of the human apoCIII enhancer are essential for the expression of the apoCIII gene and contribute to the hepatic and intestinal expression of the apoA 1 gene in transgenic mice . ^^^ The findings suggest that the SP 1 sites of the apoCIII enhancer are required for the expression of the apoCIII gene and also contribute significantly to the hepatic and intestinal expression of the apoA 1 gene in vivo . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
This mechanism accounts for the increase in lipolysis ( modulation of apoCIII and lipoprotein lipase ) and in HDL cholesterol ( modulation of apoAI and apoAII genes ) . . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
They enhance lipoprotein lipase , apoAI and apoAII transcription and reduce that of apoCIII . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The TC / HDL C ratio increased , while that of HDL C / apoAI and apoAI / apoCIII decreased . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Serum lipid parameters ( total cholesterol ( TC ) , HDL C , LDL C , TG , apoA 1 , apoB , apoCIII ) , lipoprotein composition and LDL size were determined before initiation of lopinavir / ritonavir containing regimen , and at 1 and 3 months thereafter . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Studies in transgenic mice established that the hepatocyte nuclear factor ( HNF 4 ) binding site of the apoCIII enhancer , which controls transcription of both genes , is required for the intestinal expression of apoA 1 and apoCIII genes , and enhances synergistically their hepatic transcription in vivo . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Total cholesterol , HDL C , LDL C , triglycerides , apoA 1 , apoB , apoCIII , lipoprotein composition , LDL size and LDL resistance to copper induced oxidation were determined before initiation of fenofibrate or Vitamin E , and 3 and 6 months thereafter . ^^^ Three months of fenofibrate treatment results in a significant decrease in triglycerides ( 40 % ) , apoCIII ( 21 % ) , total cholesterol ( 14 % ) , apoB ( 17 % ) levels , non HDL C ( 17 % ) , TG / apoA1 ratio in HDL ( 27 % ) associated with an increase in HDL C ( +15 % ) and apoA 1 ( +11 % ) levels . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Higher apoCIII concentrations were associated ( P < . 0001 ) with increased triglycerides ( r = 0 . 78 ) , total ( r = 0 . 61 ) and low density lipoprotein ( LDL ) ( r = 0 . 40 ) cholesterol , apoA 1 ( r = 0 . 26 ) , and apoB ( r = 0 . 50 ) , and these relationships persisted after controlling for age , gender , body mass index ( BMI ) , and hemoglobin A1c ( HbA1c ) . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
The TaqIB restriction fragment length polymorphism ( RFLP ) in intron 1 of the CETP gene , the MspI in the third intron of the APOAI gene , and also SstI in the 3 ' untranslated region of the APOCIII gene were determined using standard methods . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
RESULTS : Higher apoCIII concentrations were associated ( P < . 0001 ) with increased triglycerides ( r= . 78 ) , total ( r= . 61 ) and LDL ( r= . 40 ) cholesterol , apoAI ( r= . 26 ) , and apoB ( r= . 50 ) , AER ( r= . 08 ) , and the severity of retinopathy ( ETDRS score , r= . 11 ) , and these relationships persisted after controlling for age , gender , body mass index ( BMI ) , and HbA1c level . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Lipoprotein disturbances were manifested by increased TG , non HDL C and TRL concentrations , and decreased HDL C and apoAI concentrations , whereas post renal transplant patients showed normalization of lipid and lipoprotein profiles , except for TG levels and total apoCIII and apoCIIInonB . ^^^
Interacting proteins: P02656 and P02647	Pubmed	SVM Score :0.0
Through this action , there is an increase in the transcription of some genes related to lipid metabolism , such as LLP , APOAI , APOAII , ABCA 1 , as well as decrease in the expression of APOCIII , and many other actions . . ^^^