| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Finally , comparison of sequence homology between bovine apoA 1 and the lecithin : cholesterol acyl transferase ( LCAT ) activating region of human apoC 1 suggests that several LCAT activating domains may be present in calf apoA I . . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Individual apolipoproteins were separated on a specially designed gradient sodium dodecyl sulfate polyacrylamide gel electrophoresis system cast in a conventional slab gel apparatus which resolved apoB 100 , apoE , apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 1 , and apoC 3 2 on a single gel . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| These tissue distributions indicate that nascent lipoprotein particles produced in the dog small intestine would contain apoA 1 and apoE but not apoC 1 . ^^^ Our results indicate that apoC 1 has evolved rather rapidly and that on the whole , apoA 1 is more conservative than apoE , contradictory to an earlier suggestion . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| ApoA 1 , apoC 1 , apoC III 1 and apoC III 2 did not stimulate LPL and counteracted its stimulation by apoC 2 ; MAGL , and not DAGL , was inhibited by apoA 1 and apoC 1 , an effect reversed by apoC 2 . 5 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The human plasma apoproteins apoA 1 and apoC 1 enhanced the activity of partially purified lecithin : cholesterol acyltransferase five to tenfold with chemically defined phosphatidylcholine : cholesterol single bilayer vesicles as substrates . ^^^ The activation by apoA 1 and apoC 1 differed , depending upon the nature of the hydrocarbon chains of phosphatidylcholine acyl donor . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Apoproteins from very low density ( apoC 1 , C 2 , and C 111 ) and high density ( apoA 1 and A 2 ) lipoproteins were used . ^^^ Apoprotein phospholipid complexes were much less effective in removing cellular [ 3H ] phosphatidylcholine than the free apoproteins ; apoA 1 and apoC 1 were the best of the five apoproteins studied . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| A classification of the apolipoproteins according to their lipid binding affinity is proposed as : apoA 2 congruent to apoC 3 greater than apoC 1 greater than apoA 1 proteins . . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Apo CI , apo CII and apo CIII were expressed only in liver and apo AI mRNA was detected only in small intestine . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The genes for apoE , apoC 1 , apoC 2 , apoC 3 , apoA 1 , apoA 2 and apoA 4 have similar structures , consisting of four exons and three introns , which suggests that they evolved from a common ancestral gene . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The apolipoproteins fall into two groups : the typical apolipoproteins ( apo AI , apo AII , apo AIV , apo CI , apo CII , apo CIII and apo E ) constitute a multigene family with strong similarities in structure , genomic organization and in functional domains . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| We present the complementary DNA and deduced amino acid sequence of rat apolipoprotein A 2 ( apoA 2 ) , and the results of a detailed statistical analysis of the nucleotide and amino acid sequences of all the apolipoprotein gene sequences published to date : namely , those of human and rat apoA 1 , apoA 2 and apoE , rat apoA 4 , and human apoC 1 , C 2 and C 3 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| We found that liver is the sole or major site of synthesis of apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , and apoE , and the intestine is a major site of synthesis of apoA 1 , apoA 4 , and apoB . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| CRF patients had reduced concentrations of ApoA 1 and ApoA 2 , normal levels of ApoB and ApoC 1 , and increased concentrations of ApoC 2 and , in particular , of ApoC 3 . ^^^ In comparison with type 4 , hyperlipoproteinemic patients , CRF patients had lower concentrations of ApoA 1 , ApoA 2 , ApoB , ApoC 1 and , particularly , ApoE ; there was no difference in ApoC 3 levels reflecting the hypertriglyceridemia common to both disorders . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Results showed that patients with GSD 1 have a unique apolipoprotein profile characterized by normal or slightly decreased levels of ApoA 1 and ApoA 2 , reduced concentrations of ApoD , and significantly increased levels of ApoC 1 and ApoC 2 ( p less than 0 . 01 ) and ApoB , ApoC 3 , and ApoE ( p less than 0 . 0001 ) in comparison with age and sex matched normolipidemic controls . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| A number of immunochemical approaches were used to demonstrate that , in diabetic plasma , apo AI , apo AII , apo B , apo CI , apo E , and albumin were glucosylated . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The major apolipoproteins include apoE , apoB , apoA 1 , apoA 2 , apoA 4 , apoC 1 , apoC 2 , and apoC 3 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma lipids and 6 plasma apolipoproteins ( apoA 1 , apoA 2 , apoB , apoC 1 , apoC 2 and apoC 3 ) were studied in 23 patients with nephrotic syndrome . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| These genes include those encoding various apolipoproteins ( apo ) , including apoA 1 , apoA 2 , apoA 4 , apoB , apoC 1 , apoC 2 , apoC 3 , apoE , and apo ( a ) , cholesteryl ester transfer protein ( CETP ) , HDL binding protein , lipoprotein lipase , and the low density lipoprotein ( LDL ) receptor . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Enzyme linked immunoassays were used to quantify apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , apoE and apo B 100 in Lp [ a ] and autologous LDL isolated from three healthy males . ^^^ In contrast , the autologous LDL preparations contained relatively higher amounts of apoA 1 , apoA 2 , apoE , apoC 1 , apoC 2 and apoC 3 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The apoC 1 fragment and modified apoA 1 presented at equimolar concentrations exhibited similar inhibition of cholesteryl ester transfer protein ( CETP ) activity in HDL of low HDL 1 baboons . ^^^ Rabbit polyclonal antisera prepared against the 38 amino acid synthetic peptide recognized the 4 kDa molecular mass inhibitor protein , apoC 1 ( 6 . 6 kDa ) , and the modified apoA 1 protein ( 31 kDa molecular mass ) in the plasma lipoproteins of high HDL 1 baboons . ^^^ These studies suggest that the CETP inhibitor is an N terminal fragment of apoC 1 , and this fragment also modifies apoA 1 and apoE in the plasma . . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Incubation of chylomicrons with purified apolipoprotein ( apo ) E or C 2 resulted in more rapid clearance of these particles from the plasma , whereas incubation of chylomicrons with apoA 1 , apoC 1 , apoC III 1 , or apoC III 2 , did not affect their clearance rates . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| CE of the lipid free apoprotein mixture shows the presence of apoC 1 , 2 , 3 and apoE in the VLDL fraction , and apoA 1 , 2 apoC 1 and apoE in the HDL fraction . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Five of the peptides correspond to proposed lipid binding domains of human apolipoproteins [ apoC 1 ( 7 24 ) , apoC 1 ( 35 53 ) , apoA 2 ( 18 30 ) + , apoA 1 ( 166 185 ) , apoE ( 267 289 ) ] , and the sixth is the de novo lipid associating peptide LAP 20 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Plasma turnover of HDL apoC 1 , apoC 3 , and apoE in humans : in vivo evidence for a link between HDL apoC 3 and apoA 1 metabolism . ^^^ In order to better define the role of HDL apolipoproteins in determining plasma HDL concentrations , the aims of the present study were : a ) to compare the in vivo rate of plasma turnover of HDL apolipoproteins [ i . e . , apolipoprotein A 1 ( apoA 1 ) , apoC 1 , apoC 3 , and apoE ] , and b ) to investigate to what extent these metabolic parameters are related to plasma HDL levels . ^^^ Plasma HDL apolipoprotein levels were 41 . 8 + / 1 . 5 , 9 . 7 + / 0 . 5 , 4 . 9 + / 0 . 5 , and 0 . 7 + / 0 . 1 micromol / l for apoA 1 , apoC 1 , apoC 3 and apoE . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The analyzed markers correspond to polymorphic sites in several candidate genes for cardiovascular disease including apolipopoteins and their receptors ( APOA 1 , APOB , APOE , APOC 1 , APOC 2 , LPA , and LDLR ) , genes implied in the hemostasis regulation ( Factor 7 , alpha and beta fibrinogen , alpha and beta platelet integrin , tissue plasminogen activator , and plasminogen activator inhibitor 1 ) , and the angiotensin converting enzyme gene . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Kinetic stabilization and fusion of apolipoprotein A 2 : DMPC disks : comparison with apoA 1 and apoC 1 . ^^^ Comparison of the unfolding rates and the melting data recorded by differential scanning calorimetry , CD , and light scattering indicates the rank order for the kinetic disk stability , apoA 1 > apoA 2 > apoC 1 , that correlates with protein size rather than hydrophobicity . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The sdLDLs of both types of patients were enriched in apolipoprotein C 3 ( apoC 3 ) and were depleted of apoC 1 , apoA 1 , and apoE compared with matched healthy controls with the A phenotype . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Mass spectrometry showed that the apoM containing lipoproteins also contained apoJ , apoA 1 , apoA 2 , apoC 1 , apoC 2 , apoC 3 , paraoxonase 1 , and apoB . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| The molecular masses of apoA 1 , proapoA 1 , apoA 2 , proapoA 2 , apoC 1 and apoC 3 were obtained . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical classification of the amyloid deposits was conducted using antisera directed against amyloid A , apolipoprotein A 1 , apolipoprotein A 2 , apolipoprotein B , apolipoprotein C 1 , lysozyme , lambda and kappa light chain amyloid fibril proteins , transthyretin , beta 2 microglobulin , and amyloid P component . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Especially high sensitivity and resolution were obtained in the region < 30 kDa , where multiple isoforms of apolipoprotein A 1 , apolipoprotein A 2 , apolipoprotein C 1 , apolipoprotein C 2 , apolipoprotein C 3 , and transthyretin could be assigned . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Major components of the multiprotein index included haptoglobin , C3a complement fraction , transferrin , apolipoprotein C 1 and apolipoprotein A 1 . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Human apoA 1 expression in CETP transgenic rats leads to lower levels of apoC 1 in HDL and to magnification of CETP mediated lipoprotein changes . ^^^ A number of HDL apolipoproteins , including rat apoA 1 and rat apoC 1 are removed from the HDL surface as a result of human apoA 1 overexpression . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| Combination therapy reduced total plasma TG ( 28 % ) , LDL cholesterol ( LDL C , 10 % ) , apoB ( 16 % ) , apoB / apoA 1 ratio ( 21 % ) while increasing HDL cholesterol ( HDL C , 21 % ) , total plasma apoA 1 ( 12 % ) , LpA 1 ( 43 % ) , and apoC 1 ( 26 % ) . ^^^ Combination therapy increased HDL L CE / TG ( 32 % ) , apoC 1 ( 30 % ) , apoA 1 ( 56 % ) , and LpA 1 ( 70 % ) , as well as HDL M CE ( 35 % ) , phospholipids ( 24 % ) , total mass ( 19 % ) , apoC 1 ( 25 % ) , apoA 1 ( 18 % ) , and LpA 1 ( 56 % ) . ^^^ |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P02654 and P02647 |
Pubmed |
SVM Score :0.0 |
| NA |
|