| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Dose dependent induction by TGF beta 1 was observed for both HSP 47 mRNA and collagen alpha 1 ( 1 ) mRNA , and actinomycin D inhibited this increase of HSP 47 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Elevated expression of collagen alpha 1 ( 3 ) chain and TGF beta 1 mRNAs , and its reversal by saralasin were also demonstrated in stretched SMCs . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Northern analysis showed abundant TGF beta 1 mRNA in AOM induced tumors , but not in paired mucosa . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| PTX also suppressed both basal and TGF beta 1 augmented collagen alpha 1 ( 1 ) and collagen alpha 1 ( 3 ) mRNA levels beginning at 24 h , and attenuated both basal and TGF beta 1 ( 5 ng / ml ) stimulated total collagen synthesis at 48 h . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Bacterial cell wall polymers directly stimulated collagen alpha 1 ( 1 ) , TGF beta 1 , IL 1beta , and IL 6 mRNA expression in the intestinal myofibroblasts derived from both normal and inflamed cecum . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Significant increases in mRNA for fibronectin ( 7 . 5 fold , P < 0 . 01 ) , heparan sulfate proteoglycan core protein ( 53 fold , P < 0 . 001 ) , laminin beta 1 ( 12 fold , P < 0 . 001 ) , collagen alpha 1 ( 4 ) ( 17 fold , P < 0 . 001 ) , collagen alpha 1 ( 3 ) ( fourfold , P < 0 . 001 ) , and MMP 9 ( twofold , P < 0 . 05 ) were observed after perfusion with TGF beta 1 . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Neointima formation and TGF beta 1 immunoreactivity were correlated with increases in fibronectin , collagen alpha 2 ( 1 ) , and collagen alpha 1 ( 3 ) gene expression . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| The effect of TGF beta 1 on the expression of the basement membrane genes , fibronectin , laminin B 1 , and collagen alpha 1 ( 4 ) , was examined . ^^^ Treatment of these differentiated cells with TGF beta 1 induced the expression of fibronectin mRNA to levels seen in TGF beta treated , undifferentiated keratinocytes but only marginally increased the expression of collagen alpha 1 ( 4 ) and laminin B 1 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| RNA was isolated after the addition of varying amounts of TGF beta 1 to the cells in culture for varying periods of time , and collagen alpha 1 ( 4 ) RNA was quantitated by filter hybridization . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNAs encoding TGF beta 1 ( in both mouse and human ) , entactin , fibronectin , and the collagen alpha 1 ( 4 ) and alpha 2 ( 4 ) chains were significantly induced in total kidney as a function of Alport renal disease progression . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| We postulated that TGF beta 1 and TbetaR 2 alterations may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen , azoxymethane ( AOM ) . ^^^ In the present study , normal colon tissues and AOM induced colon tumors from SWR / J mice were analyzed for mutational changes in the TbetaR 2 gene , and the expression and localization of TGF beta 1 and TbetaR 2 were examined by reverse transcription polymerase chain reaction ( RT PCR ) and immunohistochemisty . ^^^ These findings suggest that alterations in the expression of TGF beta 1 and TbetaR 2 may be involved in the pathogenesis of colon tumors induced by AOM in mice . . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Cellular ANG , TGF beta 1 , and collagen alpha 1 ( type 4 ) mRNA levels were determined by Northern blot analysis or by reverse transcriptase PCR assay . ^^^ The results showed that stable transfer of antisense ANG cDNA into IRPTC suppressed the basal TGF beta 1 and collagen alpha 1 ( type 4 ) mRNA expression and blocked the stimulatory effect of high glucose ( i . e . , 25 mM ) on TGF beta 1 and collagen alpha 1 ( type 4 ) mRNA expression and induction of IRPTC hypertrophy . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Renal cortical mRNA levels of TGF beta 1 , collagen alpha 1 ( 4 ) , collagen alpha 1 ( 1 ) , decorin , and the household gene glyceraldehyde 3 phosphate dehydrogenase in biopsy specimens taken during acute rejection episodes were quantified by real time polymerase chain reaction . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Constructs of promoter and first intron sequences associated with the luciferase reporter gene were used to delineate the gene sequences involved in TGF beta 1 control of human COL2A1 gene transcription . ^^^ Cotransfection of these DNA fragments with a TbetaRII / I cDNA hybrid receptor , capable of inducing a TGF beta 1 dominant negative effect , showed that TGF beta 1 inhibits specifically COL2A1 gene transcription in RAC by a 63 bp proximal promoter . ^^^ Transfection of decoy Sp binding oligonucleotides corroborated the implication of the proximal promoter in the TGF beta 1 induced inhibition of COL2A1 gene transcription . ^^^ These findings suggest that TGF beta 1 inhibition of COL2A1 gene transcription in RAC is mediated by an increase of the Sp3 / Sp1 ratio and by the repression of Sp 1 transactivating effects on that gene . . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| In cells lacking Sp 1 and KLF 6 , transfected KLF 6 and Sp 1 cooperatively transactivated the endoglin promoter and those of collagen alpha 1 ( 1 ) , urokinase type plasminogen activator , TGF beta 1 , and TGF beta receptor type 1 . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| To determine the expression and activation status of TGF beta 1 in chemically induced tumors , 6 wk old A / J mice were injected intraperitoneally with either azoxymethane ( AOM ) ( 10 mg / kg body weight , once a week for 6 wk ) or normal saline solution , and colon tumors were isolated 24 wk following the last injection . ^^^ To gain further insight into the functionality of the TGF beta 1 pathway , cDNA microarrays were performed and the expression levels of a panel of 21 TGF beta 1 specific target genes were determined in AOM induced tumors that overexpress the ligand . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Seventeen days after UUO , significant increases in collagen alpha 2 ( 1 ) , collagen alpha 1 ( 4 ) , TGF beta 1 and endoglin mRNA levels were detected in L kidneys vs NL kidneys . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that alpha MSH gene therapy attenuated the liver TGF beta 1 , collagen alpha 1 , and cell adhesion molecule mRNA upregulation . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that IL 10 gene therapy attenuated liver TGF beta 1 , collagen alpha 1 , fibronectin , and cell adhesion molecule mRNA upregulation . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| We also examined the effects of IL 7 , PKC inhibitor , and STAT inhibitor on the expressions of TGF beta 1 and type 1 collagen alpha 1 chain ( col1A1 ) m RNA by using real time RT PCR . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| The activation of primary and immortalized human stellate cells after incubation with apoptotic bodies , as well as their fibrogenic activity , was indicated by an increase in alpha smooth muscle actin ( primary cells ) , TGF beta 1 , and collagen alpha 1 ( 1 ) mRNA ( primary and immortalized cells ) . ^^^ The profibrogenic response was dependent upon apoptotic body engulfment , because nocodazole , a microtubule inhibiting agent , blocked both the engulfment and the increase of TGF beta 1 and collagen alpha 1 ( 1 ) mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Liver hydroxyproline content , the mRNA expression of collagen alpha 1 ( 1 ) and alpha smooth muscle actin ( alpha SMA ) , and plasma levels of transforming growth factor beta 1 ( TGF beta 1 ) were significantly reduced by olmesartan treatment , suggesting that olmesartan improved liver fibrosis . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| The effect of NS 398 , a selective COX 2 inhibitor , and PGE ( 2 ) on TGF beta 1 mediated fibrogenesis was examined by measuring mRNA levels of collagen alpha 1 ( 1 ) . ^^^ Importantly , TGF beta 1 mediated induction of collagen alpha 1 ( 1 ) was markedly suppressed by the addition of exogenous PGE ( 2 ) . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Levels of collagen alpha 1 gene expression , hydroxyproline , angiotensin 2 and TGF beta 1 proteins , and TGF beta 1 mRNA were measured on the colonic tissue . ^^^ RESULTS : In chronic colitis , captopril significantly reduced the score of macroscopic and histologic lesions , as well as the colonic tissue levels of collagen alpha 1 , hydroxyproline , ANG 2 and TGF beta 1 proteins , and TGF beta 1 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| Thus , TAK 1 increased target gene expression ( Col2a1 ) by translational or posttranslational mechanisms as a Smad 3 independent response shared by TGF beta 1 and BMP2 . . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNA expressions of collagen alpha 1 ( 1 ) , MMP 1 , TIMP 1 , TGF beta 1 were not changed by 17beta estradiol stimulations at a concentration of 10 ( 12 ) to 10 ( 8 ) M . ^^^ |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|