| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| On the other hand , a high homology to rabbit collagen , e . g . in the N terminal region of rat collagen alpha 1 chain or calf collagen alpha 2 chain , probably prevents immunological recognition by the rabbit . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Neointima formation and TGF beta 1 immunoreactivity were correlated with increases in fibronectin , collagen alpha 2 ( 1 ) , and collagen alpha 1 ( 3 ) gene expression . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| These include single point mutations in the human collagen alpha 1 ( 1 ) and rat phenylalanine hydroxylase mRNA , two engineered point mutations in a mouse collagen alpha 1 ( 1 ) mRNA , and a deletion in a human collagen alpha 2 ( 1 ) mRNA . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Acetaldehyde increased the steady state level of collagen alpha 1 ( 1 ) and collagen alpha 2 ( 1 ) mRNAs about 3 fold and had small effects on beta actin mRNA ( +50 % ) and collagenase mRNA ( 50 % ) . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| We have identified complementary DNAs from eight genes including collagen alpha 1 ( 6 ) , collagen alpha 1 ( 3 ) , decorin , complement C1r , collagen alpha 1 ( 1 ) , collagen alpha 2 ( 1 ) , and two novel genes , Q 6 and Q 10 . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Osteocalcin , osteopontin , alkaline phosphatase , type 1 collagen alpha 1 , and type 1 collagen alpha 2 mRNAs were quantified . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| By Northern analysis , expression of both chains of the type 8 collagen heterotrimer increased : collagen alpha 1 ( 8 ) mRNA expression was almost 4 fold higher than control by 7 days after vascular injury , and collagen alpha 2 ( 8 ) mRNA expression reached a maximum of almost 6 fold above baseline by 3 days after injury . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| There was an observed trend for an increasing concentration of collagen alpha 2 ( 1 ) , collagen alpha 1 ( 3 ) and lysyl oxidase mRNA molecules per cell on day 16 of development . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Sox 9 binds to essential sequences in the Col2a1 and collagen alpha 2 ( 11 ) gene ( Col11a2 ) chondrocyte specific enhancers and can activate these enhancers in non chondrocytic cells . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Mutations in the genes coding for collagen alpha 1 ( 5 ) chain ( COL5A1 ) , collagen alpha 2 ( 5 ) chain ( COL5A2 ) , tenascin 10 ( TNX ) , and collagen alpha 1 ( 1 ) chain ( COL1A1 ) have been characterized in patients with classical EDS , thus confirming the suspected genetic heterogeneity . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| RESULTS : hMFBs had typical MFB like morphology , with abundant alpha smooth muscle actin ( SMA ) but no cytoplasmic lipid droplets . hMFBs re cultured on Matrigel reverted to alphaSMA negative , lipid droplet positive quiescent morphology . alphaSMA , collagen alpha 1 ( 1 ) ( COL1A1 ) and collagen alpha 2 ( 1 ) ( COL1A2 ) messages were upregulated in hMFBs cultured on plastic , but suppressed by Matrigel . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| The effects of LY 294002 were more pronounced on the collagen alpha 1 ( 1 ) chain , which was inhibited at the transcriptional and mRNA stability levels versus collagen alpha 2 ( 1 ) chain , which was inhibited through a decrease in mRNA stability . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Collagen alpha 1 ( 1 ) chain precursor , collagen alpha 1 ( 3 ) chain precursor , collagen alpha 2 ( 6 ) precursor and collagen modifying enzymes prolyl 4 hydroxylase alpha 2 subunit precursor , procollagen lysine 2 oxoglutarate 5 dioxygenase 1 and 2 , protein disulfide isomerase ER 60 precursor and peptidyl prolyl cis trans isomerase were among the abundant proteins . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Collagen alpha 1 ( 6 ) , collagen alpha 2 ( 1 ) , fibronectin , lumican , and matrix metalloproteinase 2 were among the proteins consistently detected from control and H2O2 treated cells . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Seventeen days after UUO , significant increases in collagen alpha 2 ( 1 ) , collagen alpha 1 ( 4 ) , TGF beta 1 and endoglin mRNA levels were detected in L kidneys vs NL kidneys . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Mutations of COL2A1 , COL9A2 , COL 10 , and FGFR 3 have been reported previously in the Strudwick type of SEMD , multiple epiphyseal dysplasia type 2 ( EDM 2 ) , the Schmid type of metaphyseal dysplasia , and in achondroplasia , respectively , and the pseudoachondroplasia ( PSACH ) locus has been mapped to chromosome 19p12 . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Genetic linkage analysis of 14 candidate genes resulted in the exclusion of 10 important genes ( COL2A1 , COL9A1 , COL9A2 , COL11A1 , COL11A2 , COMP , the CPDD region , CRTL 1 , CRTM , and MMP 3 ) . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of the promoter regions for the human COL9A2 , the mouse Col9a2 and the human COL2A1 genes identified a conserved 14 bp sequence . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| The sclerotome cells in the vertebral bodies failed to differentiate into hypertrophic chondrocytes , as revealed by the undetected expression of Col10a1 and Osteopontin , and the sclerotome cells in the intervertebral discs failed to express the typical extracellular matrix proteins Col2a1 , Col9a2 and aggrecan . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Our experiments have demonstrated that the HMG box containing transcription factor , Sox 9 which binds and activates this enhancer element , is required for chondrocyte differentiation and for expression of a series of chondrocyte specific marker genes including Col2a1 , Col9a2 , Col11a2 and Aggrecan . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| SUMMARY OF BACKGROUND DATA : Mutations in the COL2A1 , COL11A1 , COL11A2 , and COL9A2 genes have been linked to spine disorders . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| METHODS : 29 Finnish probands were analysed for mutations in the genes coding for intervertebral disc matrix proteins , COL1A1 , COL1A2 , COL2A1 , COL9A1 , COL9A2 , COL9A3 , COL11A1 , COL11A2 , and AGC 1 . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| In cartilage , a number of studies indicate that Sox transcription factors are critical positive regulators in genes such as COL2A1 , COL9A2 , COL11A2 , aggrecan , and CD RAP . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| METHODS : The cartilage collagen genes , COL2A1 , COL9A1 , COL9A2 , COL9A3 , COL11A1 and COL11A2 , were screened for sequence variations in 72 Finnish probands and one US family with primary early onset hip and / or knee OA . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| The gene encoding type 2 collagen ( COL2A1 ) was tested for genetic linkage to MED in this family by restriction fragment length polymorphism ( RFLP ) analysis . ^^^ Recombination between COL2A1 and MED was observed , ruling out COL2A1 as the site of the mutation . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| Zabel et al . [ 1996 : Am J Med Genet 63 ( 1 ) : 123 128 ] reported an individual with short stature and SPD who was heterozygous for a frameshift mutation in the C propeptide domain of COL2A1 . ^^^ |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14055 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|