| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 2 beta 1 is a positive regulator of collagenase ( MMP 1 ) and collagen alpha 1 ( 1 ) gene expression . ^^^ |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| Here , we have studied in human KHOS 240 and MG 63 osteosarcoma cells and in human skin fibroblasts the effects of tyrosine kinase inhibitors on collagen gel contraction and on the regulation of MMP 1 and collagen alpha 1 ( 1 ) genes by extracellular collagen . ^^^ Thus , the collagen induced alterations in the expression of MMP 1 and collagen alpha 1 ( 1 ) seem to be dependent on distinct signal transduction pathways . ^^^ Thus , we suggest that the process of collagen gel contraction requires protein tyrosine phosphorylation and that the ability of cells to contract collagen gels is not related to the induction of MMP 1 or to the level of collagen alpha 1 ( 1 ) expression . ^^^ |
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| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| Left ventricular ( LV ) mRNA [ MMP 1 , 2 , 3 , 7 , 9 , 11 , 13 , 14 ; TIMP 1 , 2 , 3 , 4 ; and collagen alpha 1 ( 1 ) and alpha 1 ( 3 ) ] and protein ( MMP 2 and MMP 9 zymographic activity ; Western blot analysis of MMP 13 , and TIMP 1 , 2 , 4 ) levels could be quantified . ^^^ |
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| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| Genes that are involved in the modulation of extracellular proteins : tropomyosin , collagen alpha 1 , MMP 1 , MMP 19 , and connective tissue growth factor . ^^^ |
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| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNA expressions of collagen alpha 1 ( 1 ) , MMP 1 , TIMP 1 , TGF beta 1 were not changed by 17beta estradiol stimulations at a concentration of 10 ( 12 ) to 10 ( 8 ) M . ^^^ |
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| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| For gene analysis , conventional and quantitative polymerase chain reactions were used for COL1A2 , COL2A1 , aggrecan , BMP 2 , biglycan , decorin , osteonectin , fibromodulin , fibronectin , matrix metalloproteinase 13 ( MMP 13 ) , and tissue inhibitor of MMP 1 . ^^^ |
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| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P03956 and P02458 |
Pubmed |
SVM Score :0.0 |
| NA |
|