Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
To test this hypothesis , we performed DNA sequence analysis on the highly polymorphic HLA DQB 1 and HLA DQA 1 loci of eight patients with dermatitis herpetiformis . ^^^ HLA DQ allelic typing by restriction fragment length polymorphism analysis of PCR amplified HLA DQA 1 and HLA DQB 1 fragments was also performed in ten patients with DH to determine the allelic distribution among both HLA DR 3 ( eight patients ) and non DR 3 ( two patients ) DH patients . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Therefore , the authors typed the HLA DQA 1 and HLA DQB 1 alleles in 24 sibs ( age range 85 to 97 ) of 17 centenarians by PCR SSP . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Similar studies of HLA DNA typing in Harada ' s disease frequently seen in Japan showed that frequencies of HLA DRB 1 * 0405 , HLA DQA 1 * 0301 and HLA DQB 1 * 0401 were significantly increased in patients compared with normal controls . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
In this study HLA DQA 1 and TNF genes in addition to HLA DQB 1 gene were investigated at DNA level for elucidation of the genetic backgrounds of Type 1 ( insulin dependent ) diabetes mellitus in Japanese subjects . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
DNA was extracted from blood samples and studied by Southern blot hybridisation techniques and the following probe enzyme combinations : HLA DQB 1 ; Taq 1 , HLA DQA 1 ; Taq 1 , HLA DRA ; Bgl 2 , insulin gene hypervariable region ; Pvu 2 and the switch region of the immunoglobulin IgM heavy chain gene ( S mu ) ; Sac 1 . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The observations that the HLA DQB 1 genes of MS patients share long stretches of sequence motifs and also carry DQA 1 alleles encoding glutamine at position 34 of the DQ alpha chain have received considerable attention . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
We studied the first domain of the HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 loci of 67 HLA DRw 8 positive Caucasians including 43 with early onset pauciarticular juvenile rheumatoid arthritis ( EOPA JRA , alternatively known as early onset pauciarticular juvenile chronic arthritis ) . ^^^ Approximately one fifth of the controls carried atypical HLA DRB 1 , HLA DQA 1 , and / or HLA DQB 1 loci on their HLA DRw 8 haplotype confirmed by family studies . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
We have recently reported that the susceptibility to develop celiac disease ( CD ) seems to be primarily associated to a particular combination of an HLA DQA 1 ( DQA1 * 0501 ) and an HLA DQB 1 ( DQB1 * 0201 ) allele : i . e . , a particular DQ alpha / beta heterodimer . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 and HLA DQB 1 genes may jointly determine susceptibility to develop multiple sclerosis . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Thirty myasthenia gravis ( MG ) patients ( 9 with thymoma , 12 with thymus hyperplasia and 9 with thymic atrophy ) and 181 Norwegian healthy controls were serologically typed for HLA A , B and DR antigens and genomically typed for HLA DQA 1 and HLA DQB 1 alleles by probing in vitro amplified DNA with sequence specific oligonucleotides . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 and HLA DQB 1 DNA typing in multiplex IDDM families by use of sequence specific oligonucleotide probes and genomic sequencing . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 and HLA DQB 1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion . ^^^ HLA DQA 1 and HLA DQB 1 haplotypes were determined in 37 couples with a history of recurrent spontaneous abortion ( RSAB ) , 40 of their abortuses , and 20 fertile control couples . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
These were HLA DR 5 group and HLA DQA 1 * 0601 , * 0101 0102 0104 , HLA DQB 1 * 0301 , and HLA DPB 1 * 0101 2601 alleles . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 genotypes and its interaction with HLA DQB 1 in Chinese IDDM living in Taiwan . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 , HLA DQB 1 , HLA DRB 1 and HLA DPB 1 typing result analysis are thus greatly simplified . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Frequency analysis of HLA DQA 1 and HLA DQB 1 gene alleles and susceptibility to type 1 diabetes mellitus in Russian patients . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
DNA typing for HLA DQA 1 and HLA DQB 1 antigens was performed in addition to serological typing of HLA A , HLA B , HLA C , and HLA DR antigens . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA class 2 typing for HLA DRB 1 and HLA DQA 1 was performed by restriction fragment length polymorphism ( RFLP ) analysis in 50 families , and HLA DRB 1 , HLA DQA 1 and HLA DQB 1 typing was performed by olignucleotide typing in 44 families . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Frequent HLA class 1 and DP sequence mismatches in serologically ( HLA A , HLA B , HLA DR ) and molecularly ( HLA DRB 1 , HLA DQA 1 , HLA DQB 1 ) HLA identical unrelated bone marrow transplant pairs . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Maternal fetal histocompatibility for alleles at HLA class 2 loci , HLA DQA 1 and HLA DQB 1 , was examined in 40 abortuses and 31 liveborn children of 68 couples with a history of idiopathic recurrent spontaneous abortion ( RSAB ) who underwent leukocyte immunization prior to the index pregnancy . ^^^ Non significant deficits of abortuses who were compatible for alleles at the HLA DQA 1 ( 6 observed vs . 8 . 5 expected ; P = 0 . 225 ) and the HLA DQB 1 ( 7 observed vs . 9 . 2 expected ; P = 0 . 254 ) loci were observed . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Frequent HLA class 1 and DP sequence mismatches in serologically ( HLA A , HLA B , HLA DR ) and molecularly ( HLA DRB 1 , HLA DQA 1 , HLA DQB 1 ) HLA identical unrelated bone marrow transplant pairs . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Further subdivision of IDDM patients and matched control subjects according to HLA DQA 1 and HLA DQB 1 genotype or phenotype also failed to show any association between 5 ' INS and HLA class 2 genes in diabetic patients . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
No other HLA DQB 1 allele and no HLA DQA 1 or transporter associated with antigen processing 2 ( TAP 2 ) allele were present at altered frequency in patients with gastric adenocarcinoma . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Subjects were studied for their HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 alleles . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Amplification of the second exon of HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 genes was performed by PCR , and Dot blot analysis with biotin labelled sequence specific oligonucleotide probes was used for HLA typing . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Multiple basal cell carcinomas : no association with HLA DRB , HLA DQA 1 or HLA DQB 1 in Swedish patients . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 , HLA DQB 1 genes confer susceptibility to insulin dependent ( type 1 ) diabetes mellitus ( IDDM ) . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
RESULTS : Compared with the control group , the allelic frequency of HLA DQB 1 * 0502 was significantly higher in PIH couples , and their sharing of HLA DQA 1 increased . ^^^ No difference was found in HLA DQA 1 allelic frequency or HLA DQB 1 sharing in couples of the two groups . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 and HLA DQB 1 alleles and haplotypes in two Brazilian Indian tribes : evidence of conservative evolution of HLA DQ . ^^^ Nucleotide sequence polymorphism of the HLA DQA 1 and HLA DQB 1 class 2 genes was analyzed in the Kaingang and Guarani Amerindians from southern Brazil using PCR sequence specific oligonucleotide typing methods . ^^^ These HLA DQA 1 and HLA DQB 1 alleles and haplotypes are common in many other populations of all major ethnic groups . ^^^ No novel HLA DQA 1 and HLA DQB 1 alleles have thus far been identified in Amerindians . ^^^ The more conservative evolution of HLA DQA 1 and HLA DQB 1 compared with HLA DRB 1 is strong evidence of ( still not well defined ) functional differences of these class 2 genes . . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Extremely high levels of reticulation are observed at HLA B and HLA DPB 1 , high levels at HLA A and HLA DRB 1 , moderate levels at HLA C and HLA DQB 1 , and low levels at HLA DQA 1 . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
RESULTS : Compared with the control group , the allelic frequency of HLA DQB 1 * 0502 was significantly higher in PIH couples , and the sharing of HLA DQA 1 increased in PIH couples as well . ^^^ No difference was found in HLA DQA 1 allelic frequencies or HLA DQB 1 sharing between the two groups . ^^^ Analysis of neither HLA DQA 1 nor HLA DQB 1 allelic frequencies in PIH patients and PIH mother and fetuses showed positive result . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The percentage of pairs that were allele matched was as follows ; HLA A = 91 % ( n = 80 ) , HLA B = 94 % ( n = 80 ) , HLA C = 78 % ( n = 80 ) , HLA DRB 1 = 96 % ( n = 122 ) , HLA DQA 1 = 99 % ( n = 80 ) , HLA DQB 1 = 92 % ( n = 122 ) . 92 recipient / donor pairs with informative clinical data were available for analysis . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Interactions between both HLA DMB and the HLA DRA promoter and other reported MS susceptibility loci were examined ( TCRBV polymorphisms , HLA DQA 1 and HLA DQB 1 ) . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DRB 1 , HLA DRB 3 , HLA DQA 1 , and HLA DQB 1 gene subtypes were examined by high resolution oligonucleotide typing in 122 pediatric ( PAH ) and 84 adult ( AAH ) patients and in 208 controls . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Population based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland : selective genotyping of markers in the HLA DQB 1 , HLA DQA 1 and HLA DRB 1 loci . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The human leukocyte antigen ( HLA ) complex , encompassing 3 . 5 Mb of DNA from the centromeric HLA DPB 2 locus to the telomeric HLA F locus on chromosome 6p21 , encodes a major part of the genetic predisposition to develop type 1 diabetes , designated `` IDDM1 . ' ' A primary role for allelic variation of the class 2 HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 loci has been established . ^^^ We have scanned 12 Mb of the MHC and flanking chromosome regions with microsatellite polymorphisms and analyzed the transmission of these marker alleles to diabetic probands from parents who were homozygous for the alleles of the HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 genes . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : Children with Type 1 diabetes ( n = 53 ) , unaffected first degree relatives ( n = 146 ) and unrelated healthy control children ( n = 54 ) were typed for alleles of the HLA DRB 1 , HLA DQA 1 and HLA DQB 1 genes . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : Type 1 diabetic ( n =95 ) and healthy ( n = 98 ) Italian subjects were typed for exon 5 of MIC A and for HLA DRB 1 , HLA DQA 1 , HLA DQB 1 and TNFA alleles . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : Seventy nine patients with RA and 65 ethnically matched healthy controls were genotyped for HLA DRB 1 , HLA DQA 1 , HLA DQB 1 , and TNFalpha and TNFbeta alleles using PCR amplification . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Combined segregation and linkage analysis to the major locus , showed strong linkage to HLA class 2 ( HLA DQB 1 P = 0 . 000002 , HLA DQA 1 P = 0 . 000002 , HLA DRB 1 P = 0 . 0000003 ) and tumour necrosis factor genes ( TNF P = 0 . 00002 , LTA P = 0 . 003 ) . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DRB 1 matching correlated with significantly improved survival ( relative risk [ RR ] , 1 . 29 [ 95 % confidence interval ( CI ) , 1 . 02 1 . 64 ; P = . 04 ] ) independently of HLA DQA 1 or HLA DQB 1 ( RR , 1 . 01 [ 95 % CI , 0 . 81 1 . 26 ; P = . 94 ] ) and HLA DPA 1 or HLA DPB 1 ( RR , 1 . 11 [ 95 % CI , 0 . 84 1 . 48 ; P = . 46 ] ) . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : Polymerase chain reaction restrictive fragment length polymorphism ( PCR RFLP ) was used to type HLA DQA 1 and HLA DQB 1 alleles in 30 cases of habitual abortion with anticardiolipin antibody and 90 women with normal pregnancy history . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : HLA DQA 1 and HLA DQB 1 gene typings are performed by polymerase chain reaction restrictive fragment length polymorphism ( PCR RFLP ) technique in 32 cases of unexplained habitual abortion and 54 women with normal pregnancy history . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHOD : Sequence specific primer polymerase chain reaction was used to gene frequencies of HLA DQA 1 and HLA DQB 1 genes among 125 unrelated asthmatics , 12 of which being probands of asthmatic pedigrees , and 96 healthy controls , all of Han nationality and living in Beijing or nearby areas for a long time . ^^^ RESULTS : The frequencies of HLA DQA 1 0104 and HLA DQB 1 0201 were 0 . 204 and 0 . 284 , significantly higher than those in the healthy controls ( 0 . 089 and 0 . 096 respectively , both P < 0 . 01 ) . ^^^ The correlation coefficients between HLA DQA 1 * 0104 and atopy , HLA DQB 1 * 0201 and atopy , and HLA DQA 1 * 0301 and atopy were 0 . 813 ( P < 0 . 01 ) , 0 . 289 ( P < 0 . 01 ) , and 0 . 168 ( P < 0 . 05 ) respectively . ^^^ CONCLUSIONS : The alleles HLA DQA 1 * 0104 and HLA DQB 1 * 0201 are correlated with the susceptibility to asthma among Northern of Han nationality . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Apart from HLA DQA1 * 0201 , which was less common in patients with colonic carcinoma than controls , no other HLA DQA 1 and no HLA DQB 1 allele were present at altered frequency in patients with gastric or colonic cancer . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
HLA DQA 1 and HLA DQB 1 genetic markers and clinical presentation in celiac disease . ^^^ The aim of this study was to investigate a possible correlation between the HLA DQA 1 and HLA DQB 1 genetic markers and clinical features of celiac disease . ^^^ METHODS : A total of 133 patients with celiac disease were tested for the HLA DQA 1 and HLA DQB 1 genes . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The study of HLA DQA 1 , HLA DQB 1 polymorphic alleles and DRB 1 genes and their combinations . ^^^ The genetic study included searching HLA loci ( HLA DQA 1 , HLA DQB 1 polymorphic alleles and DRB 1 genes ) loci . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
RESULTS : HLA DQA 1 * 0104 allele and HLA DQB 1 * 0201 allele were significantly higher in asthmatics than those in healthy controls ( 0 . 408 vs 0 . 177 , P < 0 . 01 ; 0 . 568 vs 0 . 198 , P < 0 . 01 ) . ^^^ Conversely , HLA DQA 1 * 0301 allele and HLA DQB 1 * 0301 were significantly decreased in asthmatics compared to healthy controls ( 0 . 296 vs 0 . 50 , P < 0 . 01 ; 0 . 4 vs 0 . 563 , P < 0 . 05 ) ; Logistic regression analysis showed that HLA DQA 1 * 0104 allele was associated independently with asthma etiology , OR [ represented by Exp ( B ) ] was 5 . 0942 with 95 % CI 2 . 2520 21 . 1813 ; Spearman ' s analysis showed that HLA DQA 1 * 0104 allele and HLA DQB 1 * 0201 allele were positively associated with atopy , the correlation coefficient were 0 . 183 and 0 . 289 respectively , P < 0 . 01 . ^^^ CONCLUSIONS : HLA DQA 1 * 0104 allele and HLA DQB 1 * 0201 allele were implicated in susceptibility to asthma and atopy , HLA DQA 1 * 0301 allele and HLA DQB 1 * 0301 might be protective factor against asthma . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The aim of this study was to estimate annual incidence rate of type 1 diabetes according to the levels of genetic susceptibility provided by HLA DQA 1 and HLA DQB 1 genotypes . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
These results suggest that the natural history of cutaneous HPV 2 / 27 / 57 induced common warts may be modulated by allele polymorphisms at the HLA DQA 1 and HLA DQB 1 gene loci . . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
Genomic DNA for HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 alleles in JDM patients and controls was determined by the direct sequence method . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
The aim of this study is to define a reliable reckoning of gene frequencies and six locus haplotypic frequencies of HLA A , HLA B , HLA C , HLA DRB 1 , HLA DQA 1 , HLA DQB 1 and HLA DPB 1 in the Tunisian population . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
METHODS : Forty nine patients with CFS were genotyped for the HLA DRB 1 , HLA DQA 1 , and HLA DQB 1 alleles and the frequency of these alleles was compared with a control group comprising 102 normal individuals from the UK . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
In this study , associations between HLA polymorphisms at three loci ( HLA DQB 1 , HLA DQA 1 , and HLA DRB 1 ) and posttreatment Ig responses to S . mansoni Ags were assessed in 199 individuals aged 7 50 years from Uganda . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
A total of 460 patients was typed for HLA DQB 1 alleles , among them 97 also for HLA DQA 1 and 146 for HLA DRB 1 alleles . ^^^
Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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Interacting proteins: P01920 and P01906 Pubmed SVM Score :0.0
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