| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| Evidence that the Kp 43 ( CD 94 ) molecule functions as receptor for HLA B alleles . ^^^ Thus , mAb mediated masking of Kp 43 molecules interferes with recognition of HLA B 7 and results in target cell lysis . ^^^ Moreover , in a redirected killing assay , the cross linking of Kp 43 molecules mediated by the XA 185 mAb strongly inhibited the cytolytic activity of HLA B 7 specific NK clones , thus mimicking the functional effect of B 7 molecules . ^^^ Taken together , these data strongly suggest that Kp 43 molecules function as receptors for HLA B 7 and that this receptor / ligand interaction results in inhibition of the NK mediated cytolytic activity . ^^^ Indirect immunofluorescence and FACS analysis of a large number of random NK clones showed that Kp 43 molecules ( a ) were brightly expressed on a subset of p 58 negative clones , corresponding to those specific for HLA B 7 ; ( b ) displayed a medium / low fluorescence in the p 58 negative clones that are not B 7 specific as well as in most p58+ NK clones ; and ( c ) were brightly expressed as in the p58+ clone ET 34 ( GL 183 / EB6+ , Cw 4 specific ) . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| Recently , we described an NK cell receptor , NKB 1 , that inhibits NK cells from killing target cells expressing Bw 4 reactive HLA B molecules ( B * 2705 , B * 5101 , B * 5801 ) . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| We describe a potential human NK cell receptor ( NKB 1 ) for certain HLA B alleles ( e . g . , HLA B * 5101 and B * 5801 ) identified by the mAb DX 9 . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| CD 94 and a novel associated protein ( 94AP ) form a NK cell receptor involved in the recognition of HLA A , HLA B , and HLA C allotypes . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| Nevertheless , a more accurate functional analysis demonstrated not only that HSV infection downregulated the expression of HLA A and HLA B and did not modify the expression of HLA C , but also that NK cell clones expressing the `` activating ' ' form of the anti HLA C NK cell receptor were more cytolytic than other clones . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| CD 94 molecules have been suggested to function as inhibitory natural killer cell ( NK ) receptors involved in the recognition of HLA B alleles sharing the Bw 6 supertypic specificity . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| Strong support for the involvement of the CD 94 C type lectin receptor complex in NK cell mediated recognition of Bw6+ HLA B , HLA A and HLA C alleles has been obtained . ^^^ |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13241 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|