| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.53625528 |
| As the five peptides bound to HLA B * 2705 with similar stability , these data demonstrate that a single KIR specific for several HLA B allotypes recognizes a subset of peptides bound to HLA B * 2705 . . 0.53625528^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Functional studies have identified two distinct p 58 KIR , each reactive with a different group of HLA C allotypes , and distinct p 70 KIR specific for some HLA B or HLA A allotypes . ^^^ Here , we show that a soluble p 70 KIR binds to HLA B * 5101 , but not to HLA A or HLA C molecules . ^^^ Truncated soluble forms of the HLA B * 5101 specific p 70 KIR , including one with two immunoglobulin ( Ig ) domains reactive with a monoclonal antibody that blocks p 70 KIR function , did not bind to HLA B * 5101 , indicating that all three Ig domains are required for binding . . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| DX9+ KIR specifically focus on HLA B residues 82 and 83 . ^^^ |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Most individuals expressed inhibitory KIR for the three well defined HLA B and C ligands , but noninhibitory KIR genes were more variable . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| DX 9 mAb binding killer cell inhibitory receptors ( KIR ) recognize HLA B molecules that express the Bw 4 public serologic epitope . ^^^ Natural cytotoxicity and IFN gamma production were coordinately regulated by a panel of HLA B 7 variants expressed on 721 . 221 cells , suggesting that these two effector functions are inhibited by the same KIR mediated signaling mechanisms . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Most individuals ( 93 % ) possessed the complement of inhibitory KIR specificities for the three well defined HLA B and C ligands . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Here we report that the activating KIR allele KIR3DS1 , in combination with HLA B alleles that encode molecules with isoleucine at position 80 ( HLA B Bw 4 80Ile ) , is associated with delayed progression to AIDS in individuals infected with human immunodeficiency virus type 1 ( HIV 1 ) . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| We also investigated the frequency of HLA B alleles sharing the same natural killer cell immunoglobulin like receptor ( KIR ) binding sequence with HLA B 51 . ^^^ HLA B alleles reacting with the sequence specific oligonucleotide probe 23 , which corresponds to the KIR binding site of B * 51 , were found to be positive in 127 BD patients ( 73 % ) and 90 controls ( 47 % ) ( OR = 3 . 03 , 95 % CI 2 4 . 7 ) . ^^^ The repeated RPE analysis after separating HLA B alleles carrying B 51 KIR binding sequence as distinct alleles within a broad type allele group revealed B * 2702 allele as the only allele showing an association with BD after the deletion of B * 51 . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Associations between KIR epitope combinations expressed by HLA B / C haplotypes found in an HIV 1 infected study population may influence NK mediated immune responses . ^^^ We observed a significant association between particular combinations of KIR epitopes expressed by HLA B / C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA B and HLA C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and / or other infectious pathogens . . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| We examined whether KIR genes act in concert with HLA B locus to control HIV 1 infection in a sample of Zambian patients . ^^^ All were typed for HLA B and KIR genes . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| We here report four novel full length cDNA transcripts encoding KIR3DL1 like proteins isolated from mRNA obtained from interleukin 2 activated peripheral blood mononuclear cells of a donor with two HLA B antigens expressing the Bw 6 epitope . ^^^ Functionally , the KIR3DL1 receptors expressed by five DX 9 positive NK clones were not inhibiting NK mediated cytotoxicity when tested against the 721 . 221 B lymphoblastoid cell line expressing a HLA B antigen with Bw 4 epitope . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| In contrast to the KIR2D : HLA C interaction , little is known of KIR3DL1 ' s interaction with HLA B or the role of D 0 , the domain not present in KIR2D . ^^^ Domain swap , deletion , and site directed mutants of KIR3DL1 were analyzed for HLA B binding using a novel , positively signaling cell cell binding assay . ^^^ Natural ' deletion ' of residues 50 and 51 from its D 0 domain causes Pt KIR3DL1 / 2 to bind Bw 4 ( + ) HLA B allotypes more avidly than does KIR3DL1 . ^^^ Deletion of these residues from KIR3DL1 , or their substitution for alanine , enhanced binding of Bw 4 ( + ) HLA B . ^^^ None of 15 different point mutations in D 0 abrogated KIR3DL1 binding to Bw 4 ( + ) HLA B . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| On the other hand , HLA B and HLA C down regulation in iDC was not sufficient to induce cytotoxicity in NK cells expressing KIR3DL1 or KIR2DL . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| KIR3DL1 is an inhibitory HLA B receptor of human NK and T cells that exhibits genetic and phenotypic polymorphism . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| The NKB 1 and HP 3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA B and HLA C molecules . ^^^ Recently , we described an NK cell receptor , NKB 1 , that inhibits NK cells from killing target cells expressing Bw 4 reactive HLA B molecules ( B * 2705 , B * 5101 , B * 5801 ) . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NKB 1 : a natural killer cell receptor involved in the recognition of polymorphic HLA B molecules . ^^^ We describe a potential human NK cell receptor ( NKB 1 ) for certain HLA B alleles ( e . g . , HLA B * 5101 and B * 5801 ) identified by the mAb DX 9 . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Cells expressing NKB 1 are often found in donors who do not possess an appropriate class 1 ligand , and can be absent in those who express Bw4+ HLA B antigens . ^^^ |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NKB 1 : a killer cell inhibitory receptor for class 1 HLA B allotypes . ^^^ |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Cytolysis by NK cells that possess the NKB 1 killer cell inhibitory receptor is inhibited by target cell expression of Bw4+ HLA B molecules . ^^^ |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| The Bw 4 public epitope of HLA B molecules confers reactivity with natural killer cell clones that express NKB 1 , a putative HLA receptor . ^^^ These results show that the presence of the Bw 4 epitope influences recognition of HLA B molecules by NK cells that express NKB 1 , and suggest that the NKB 1 molecule may act as a receptor for Bw4+ HLA B alleles . ^^^ Sequences outside of the Bw 4 region must also affect recognition by NKB1+ NK cells , because lysis of transfectants expressing HLA A * 2403 or A * 2501 , which possess the Bw 4 epitope but are in other ways substantially different from HLA B molecules , was not increased by addition of the anti NKB 1 antibody . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| While a human homolog of Ly 49 has not been identified as yet , two structurally distinct NK cell associated membrane glycoproteins , NKB 1 and p 58 , have been implicated in the recognition of polymorphic HLA B and HLA C molecules , respectively . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| We recently identified the NKB 1 surface Ag , expressed on T and NK cell subsets , as a putative inhibitory receptor for HLA B class 1 molecules possessing the Bw 4 serologic epitope . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| One type of inhibitory receptor , NKB 1 , was present on CD4+ and CD8+TCR alpha beta+ CTL clones and blocked the killing of staphylococcal enterotoxin B ( SEB ) coated targets bearing certain polymorphic HLA B molecules . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| Conserved and variable residues within the Bw 4 motif of HLA B make separable contributions to recognition by the NKB 1 killer cell inhibitory receptor . ^^^ Allotypes from four divergent HLA B families ( B 8 , B 15 , B 16 , and B 27 ) were compared for their inhibition of cytolysis by NK cells expressing the NKB 1 receptor . ^^^ HLA B allotypes having four different Bw 4 motifs were examined and all interact with NKB 1 . ^^^ Three types of polymorphism are implicated in formation of the ligand recognized by NKB 1 : ones shared by Bw 4 motifs ; ones distinguishing Bw 4 motifs ; and ones outside the Bw4 / Bw6 region that distinguish HLA B from HLA A . . ^^^ |
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| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| The associated genes included HLA B 13 , B 40 , B 46 , B 7 , B 57 , defined as NKB 1 genes , and HLA B 44 as NKB 2 gene . ^^^ |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43629 and P01889 |
Pubmed |
SVM Score :0.0 |
| NA |
|