Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A comparison of the transmembrane domain of Cw * 1701 with other HLA B and C alleles reveals that duplications and deletions have been common in the evolution of these loci . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In addition , these studies demonstrate that antigens other than the currently definable HLA A , HLA B , HLA C , and HLA D can serve as target determinants in cell mediated lympholysis . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thirty established cell lines from solid human tumors were typed by the mixed hemadsorption technique with respect to the HLA A and HLA B and partly also the HLA C series . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Defined specificities of the HLA C locus possess a significantly lower immunogenicity as compared with the HLA A and HLA B specificities . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The probable map order is HLA A HLA C HLA B HLA D Ir . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The comparison of the HLA A , B , and C phenotypes of 70 patients with primary open angle glaucoma ( POAG ) with the phenotypes of 450 healthy control individuals and the rather discordant data published by other investigators show that there is no genetical influence of HLA A , HLA B , or HLA C genes on POAG and on the clinical complications associated with this disease . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
No HLA A , HLA B or HLA C antigen was selectively increased among the 34 unrelated patients . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA C locus antigens in HLA B 27 associated arthritis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Linkage analysis of the data obtained from a three generation Dutch family segregating for genetic variants of centromeric heterochromatic region in the band p 11 on chromosome 6 ( 6ph ) , major histocompatibility ( MHC ) genes HLA A , HLA B and HLA C , glyoxalase 1 ( GLO ) and phosphoglucomutase 3 ( PGM 3 ) showed that the genetic distance between the HLA gene cluster and 6ph is about 6 cM ( at an estimated peak lod score of 3 . 466 ) , that GLO is closer than HLA to the centromere and that PGM 3 is probably not situated on the same chromosomal arm as HLA . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The genetics of the serological defined SD antigens of the HLA system , which are governed by three closely linked loci ( HLA A , HLA B and HLA C ) situated on the chromosome C 6 , are described . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The HLA A , B , C haplotype frequencies determined through family investigations in 500 unrelated individuals of the Viennese population were calculated , as well as the gene frequencies of 37 HLA determinants and the linkage disequilibria between the three HLA SD loci ( HLA A , HLA B , and HLA C ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The results provide further data on the relative position of the loci for HLA A , HLA B , HLA C , HLA D , Bf , Chido , Rodgers and PGM 3 on chromosome 6 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thus the immunogenetic linkage group on human chromosome C 6 has been increased by yet another outside marker gene to include now the following genes in this order : HLA A HLA C HLA B Bf HLA D GLO PGM3 . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Within the antigen recognition site , it is the alpha 1 domain that is most diagnostic of HLA C , whereas the alpha 2 domain is similar to that of HLA B , the locus to which HLA C is most closely related . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Eighty eight unrelated patients with JME were typed for the HLA A and HLA B locus , 77 were typed for the HLA C locus , and 76 were typed for the DR locus . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
RESULTS : Sharing of two or more HLA A , HLA B , HLA C , or HLA DR antigens was observed in 41 % ( 252 / 609 ) couples with recurrent spontaneous abortion and in 34 % ( 31 / 92 ) with infertility compared with 63 % ( 27 / 43 ) of fertile couples . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
One hundred and sixteen out of 120 HLA A antigens , 125 / 127 HLA B , 106 / 108 HLA C , and 92 / 100 HLA DR antigens were identical using the same technique . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The sequences obtained from the 60 clones were each interpreted to correspond to one of the classical loci , HLA A , HLA B , and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In 88 other alpha chain sequences from the HLA A , HLA B , HLA C , HLA D , HLA E , HLA F and HLA G locus products in man and the H 2 , Qa and Tla loci in mouse , 37 contact sites were conserved to 90 % or more , and in beta 2m sequences from seven other species 40 % of contact sites were totally conserved . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
All MM cell lines constitutively expressed class 1 , but not class 2 , surface antigen , and all three class 1 loci ( HLA A , HLA B , and HLA C ) were expressed . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Isolation and characterization of yeast artificial chromosome clones linking the HLA B and HLA C loci . ^^^ A 290 kilobase pair chromosomal segment containing the genes encoding the human class 1 major histocompatibility complex molecules HLA B and HLA C as well as a class 1 pseudogene has been isolated on three overlapping yeast artificial chromosome ( YAC ) clones . ^^^ One YAC clone contains both the HLA B and HLA C genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Locus HLA A alone was ruled out in 8 . 01 % , locus HLA B in 28 . 17 % ; in a single case the man was ruled out in locus HLA C only . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Peptides from the alpha 1 domain helix of other HLA A and HLA B molecules , but not HLA C molecules , competed with the HLA B 7 peptide for binding to HLA DR11 . 1 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Promoter region of HLA C genes : regulatory elements common to and different from those of HLA A and HLA B genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
These include the genes for the three major transplantation antigens , HLA A , HLA B , and HLA C , as well as a number of other genes or pseudogenes of unknown biological significance . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In a series of 123 sarcoidosis patients ( inhabitants of Moravia ) , frequencies of 15 HLA A , 31 HLA B , and 7 HLA C antigens have been found . ( Control group consisted of 500 healthy persons from the same region . ) A subgroup of 46 patients was examined in order to determine a frequency of 10 HLA DR antigens . ( Control group consisted of 146 persons . ) A positive association was proved between sarcoidosis and the HLA B 8 and B 13 antigens ( RR = 2 . 8 and RR = 3 . 1 , respectively ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thirty one patients with gallbladder cancer ( GBC ) and 32 healthy controls were typed using antisera against 12 HLA A , 31 HLA B , 7 HLA C and 13 HLA DR antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
These biochemical HLA C `` splits ' ' were characterized not only by different isoelectric points but also by strong linkage disequilibriums with certain HLA B antigens . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The potential contributions of shared amino acid sequences , the occurrence of multiple epitopes on a single HLA B molecule , and the presence of new HLA C antigens have been difficult to resolve . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The study aimed at : 1 ) assessing occurrence of HLA A , HLA B and HLA C antigens in patients with Graves ' disease in comparison with control group of healthy individuals ; 2 ) determining relationship between circulating serum antimicrosomal and antithyroglobulin antibodies and selected HLA complex antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The distribution of 12 HLA A , 14 HLA B , seven HLA C , seven HLA DR and three HLA DQ antigens was determined in 32 non consanguineous white Brazilians suffering from chromoblastomycosis and 77 healthy controls , matched for ethnic background , sex and age and living in the same geographical area . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The tumor necrosis factor ( TNF ) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA B , HLA C , and , tentatively , HLA E and HLA A on one side and to the class 3 complement / steroid 21 hydroxylase gene cluster on the other by pulsed field gel electrophoresis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We then map precisely the HTF islands of the HLA B and HLA C genes and determine that they are separated by 130 Kb ( in agreement with genetic data ) and that these two genes are in the same transcriptional orientation on the chromosome . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The nucleotide sequence of pC 68 showed higher homology with exons of the HLA C gene than with those of the HLA A and HLA B genes , especially in exons 6 8 which include the HLA C specific region . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Another case of an HLA B / HLA C recombination is presented which shows that the locus HLA C is situated between HLA A and HLA B . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
When LCL ' s were compared with their matching PBL , HLA phenotypes were concordant in 87 % of cases for HLA A , 90 % for HLA B , 81 % for HLA C and 70 % for HLA DR . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The occurrence of this band on Southern blots established that JY 328 maps distinct from and centromeric to the HLA C locus and near to the HLA B locus . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Both probes are used to show a high level of DNA sequence homology between the 5 ' flanking region of HLA B and HLA C . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The present study was undertaken in 117 new patients with Graves ' disease , typed for HLA A , HLA B , HLA C and DR antigens and IgG heavy chain markers , to determine whether these characteristics could be used to segregate patients into clinically relevant subsets . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In the third child , the paternal haplotype had a recombination between HLA A and HLA C and the maternal haplotype a recombination between HLA B and complement locus C 4 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
It is also clear that complex maternal immunologic responses , including antibodies to red blood cell antigens , HLA A , HLA B , HLA C , and HLA D antigens , and cell mediated responses such as proliferation , lymphokines , cytotoxicity , and suppressor cells , are generated to a variety of paternal antigenic determinants . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Strikingly , no positive linkage disequilibrium between C4A and C4B alleles is detected in unrelated individuals nor in families , although strong associations are maintained among Bf , C 2 , C 4 , HLA A , HLA B , HLA C and HLA DR markers . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA A , HLA B , HLA C , HLA Bw 4 , Bw 6 and HLA DR antigens have been detected on purified seminal cells than spermatozoa ( SCnonSz ) using specific absorptions . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In order to investigate if genetic factors could be involved in the pathogenesis of hypertrophic obstructive cardiomyopathy , we determined HLA A , HLA B , HLA C , and HLA DR specificities in 12 Italian patients affected with the disease and in healthy family members of one of them . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Although no significant difference was found for HLA A , HLA B , and HLA C , HLA DR 4 of the HLA D group was found in 80 % of patients but only in 38 . 3 % of controls . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A Japanese adult lacking the expression of HLA A , HLA B , and HLA C antigens on the lymphocyte ( the `` bare lymphocyte syndrome ' ' ) had recurrent sinopulmonary infections and diffusely progressive bronchiectasis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The cells reacted with monoclonal antibodies anti Leu 7 and anti Leu M 1 but did not react with antibodies to human lymphocyte antigens ( HLA ) A , HLA B , and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Monoclonal antibodies raised against denatured HLA B locus heavy chains permit biochemical characterization of certain HLA C locus products . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The HLA system in Italy . 4 , 902 Italians were typed for HLA A antigens , 4 , 721 for HLA B and 1 , 503 for HLA C . ^^^ The samples , which were composed of unrelated , healthy individuals born in Italy , were used for estimating HLA A , HLA B and HLA C gene frequencies with the maximum likelihood method . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Derivation of locus specific oligonucleotide probes specific for HLA A , HLA B , and HLA C genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In 23 patients the HLA A , HLA B , HLA C and HLA DR patterns were determined ; 27 % of the patients showed systemic organ manifestations . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The significance of the results is discussed in terms of the cell differentiation in these diseases , including the function of beta 2 m related to the function of the classical HLA antigens ( HLA A , HLA B , HLA C ) . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The number of healthy controls was 272 and 102 for classes 1 and 2 , respectively . 17 HLA A , 31 HLA B , 7 HLA C and 8 HLA DR specificities were studied . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Twenty two Japanese patients with glaucomatocyclitic crisis were typed for HLA A , HLA B , and HLA C antigens to detect the immunogenetic factors in this disease . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The frequency distribution of the 14 HLA A , 18 HLA B , 5 HLA C and 10 HLA D antigens , which were tested , was similar in patients with obstructive , provocable obstructive or non obstructive HCM to that of a control group of 800 normal persons . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
However , identity of HLA B and HLA C antigens was not enough for a significant killing of allogeneic LCL . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Immunoprecipitation analyses showed that no surface immunoglobulin M was bound , but that most of the histocompatibility antigens HLA A , HLA B , HLA C and HLA DR were . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We have confirmed that many women who suffer from recurrent spontaneous abortions have an increased incidence of histocompatibility ( HLA A , HLA B , HLA C , and HLA DR ) antigen sharing with their husbands . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The significant information which results from this study includes : 1 ) a failure to confirm previous reports on HLA DR antigen increased frequencies ; 2 ) an association , in this population , of BW 39 with PSA and not BW 38 ; 3 ) finding of a closer link of PSC and PSA with HLA C rather than HLA B antigens ; 4 ) an estimate of relative risk for patients with PSC to develop PSA . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The fourth aspect of this article concerns the mechanism and the HLA A , HLA B and HLA C antigen mediated genetic control of the elimination of altered self structures by cytotoxic lymphocytes . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
No HLA A , HLA B or HLA C specific antigen is selectively increased among the 5 unrelated families affected with renal glycosuria . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The purpose of this study was to determine the frequency of HLA A , HLA B and HLA C haplotypes in patients resistant to chronic periodontitis and to determine if there is any association between specific HLA genes and periodontal health . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Twenty patients with histopathologically confirmed sympathetic ophthalmia ( Group 1 ) and eight patients with `` presumed sympathetic ophthalmia , ' ' based on a clinical history of bilateral uveitis occurring within four months of a perforating ocular injury ( Group 2 ) , were typed for HLA A , HLA B , and HLA C antigenic determinants by a micro lymphocytotoxicity technique . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Among the 37 specificities of the HLA system studied ( 17 of HLA A , 16 of HLA B , and 4 of HLA C series ) , only HLA BW 16 showed a tendency to be more frequent in women with ICP rather than in control women . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The applicability of this compound in the identification of specific cell surface proteins was demonstrated using a monoclonal antibody reactive with beta 2 microglobulin , a protein which is associated with the human histocompatibility antigens ( HLA A , HLA B , HLA C ) . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The relationships between the HLA A , HLA B and HLA C antigens and diabetic end stage nephropathy were therefore evaluated in the present study . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Some of the substitutions of Cw * 0704 have not been previously described for HLA C but are found in HLA B alleles and in published C sequences of non human primates . ^^^ It is most often observed on HLA B 44 haplotypes previously described as HLA C `` blank ' ' , although linkage disequilibria with other HLA B specificities have been found . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Bw 4 and BW 6 epitopes are expressed by mutually exclusive sets of HLA B alleles and some HLA A and HLA C alleles . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
While a human homolog of Ly 49 has not been identified as yet , two structurally distinct NK cell associated membrane glycoproteins , NKB 1 and p 58 , have been implicated in the recognition of polymorphic HLA B and HLA C molecules , respectively . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA A , HLA B , HLA C , and HLA D typing was performed in 47 mothers of patients suffering from ocular toxoplasmosis to investigate whether an immunogenetic predisposition exists for developing congenital toxoplasmosis in their offspring . ^^^ HLA A , HLA B , and HLA C typing was also performed in their children ( 52 patients with ocular toxoplasmosis ) , to investigate a possible relation between the severity of ocular toxoplasmosis and an eventual immunogenetic factor . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Eighty five percent of the chondrocytes had strong representation of Class 1 molecules , and individual specificities for HLA A , HLA B , and HLA C could be detected . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
From studies of chimeric genes spliced from the HLA B 7 and Cw 3 genes , we find that chimeric proteins containing the B 7 peptide binding groove can have low cell surface expression , suggesting that inefficiency in binding peptides is not the cause of low cell surface expression for HLA C . ^^^ We find that HLA C mRNA is expressed at lower levels than HLA B mRNA and that this difference results from faster degradation of the HLA C message . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In addition , linkage between HLA B specificities and HLA C alleles was similar to previous observations . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Phenotypes HLA A , HLA B and HLA C were determined in 85 patients with otosclerosis verified at surgery and in 113 clinically healthy subjects . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thalidomide did not modify : ( a ) adhesion and / or signal transducing molecules such as CD 2 , CD 4 , CD 5 and CD 8 , or ( b ) molecules that facilitate antigen presentation such as HLA DR , HLA A , HLA B , or HLA C . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The NKB 1 and HP 3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA B and HLA C molecules . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In addition , HLA C molecules are expressed at the cell surface at about 10 % of the levels of HLA A and HLA B . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
DX 9 monoclonal antibody ( mAb ) specifically inhibits the interaction between NK cell clones and B LCL targets transfected with certain HLA B alleles , but does not affect recognition of HLA A or HLA C antigens . ^^^ An individual NK cell clone can independently recognize B LCL targets transfected with HLA B or HLA C antigens ; however , DX 9 mAb only affects interaction with transfectants expressing certain HLA B alleles . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Before hemotransfusion the blood from the donor , recipient and their relatives was subjected to typing by various antigens of the red cell ( ABO , Rh Hr , MNSs , P , Duffy , Kidd , Kell Chellano ) and leukocyte ( HLA A , HLA B , HLA C , HLA DR ) systems . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
DNA typing for HLA DQA 1 and HLA DQB 1 antigens was performed in addition to serological typing of HLA A , HLA B , HLA C , and HLA DR antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In contrast , no difference was observed in the methylation status of the HLA B , HLA C , and HLA E genes between germ and somatic cells . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
By using individuals homozygous for specific fragments of extended haplotypes or for HLA B alleles , we found that the HLA C and B and not the complotype or HLA DR region contains genes controlling NK activity . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
LCA decreased the rate of transcription of HLA B ( 64 % ) and HLA C ( 87 % ) but not HLA A ; DCA had a similar but less pronounced effect . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We have sequenced the HLA A , HLA B , HLA C , HLA DPA 1 , and HLA DPB 1 genes expressed by 12 unrelated marrow transplant pairs , 11 of whom were molecularly matched at DRB , DQA 1 , and DQB 1 loci . ^^^ Six of these nine `` HLA identical ' ' pairs were HLA A ( 2 of 6 ) , HLA B ( 1 of 6 ) , and HLA C ( 6 of 6 ) mismatched at the sequence level . ^^^ Two of the three pairs who were serologically mismatched for one HLA A or HLA B antigen were also sequence mismatched at HLA C . ^^^ Because of their high frequency , the role of HLA A , HLA B , HLA C , and HLA DP mismatches in transplantation outcome is now amenable to direct study . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In 1974 1992 in the HLA reference laboratory of the Institute of Haematology and Blood Transfusion in Prague 15 , 731 sera sent by transfusion departments were examined ; 4368 sera met the standard required for HLA typing , detecting 9 HLA A , 18 HLA B and 3 HLA C antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
On the basis of this and other findings such as increased numbers of CD3+ and CD4+ cells , an increased ratio of CD4+ / CD8+ cells , and a reduced level of suppressor cell activity in schizophrenia and endogenous depression , we investigated the influence of the human leukocyte antigen Class 1 ( HLA A , HLA B , HLA C ) system on the altered immune function and evaluated the relationship to immune function of a family history of psychiatric disorders . ^^^ Moreover , certain HLA genes , especially HLA A 1 , HLA B 8 , HLA B 16 , and HLA C 2 seemed to be related to the immune function and / or to the immune function and the family history . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Application of HLA A , HLA B , and HLA C SBT to 26 homozygous and 32 serologically heterozygous samples has resulted in the identification of 24 novel class 1 nucleotide sequences encoding 17 new major histocompatibility complex class 1 products . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Analysis of the panel of HLA A , B , and C transfectants supported the following general conclusions . ( a ) Whereas recent studies have suggested that HLA C antigens may be preferentially recognized by NK cells , our findings indicate that 70 % or more of all NK clones are able to recognize certain HLA B alleles and many also recognize HLA A alleles . ^^^ Moreover , a single NK clone has the potential to recognize multiple alleles of HLA A , HLA B , and HLA C antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
However , 15 % of the invasive carcinomas completely lacked HLA B and HLA C antigen expression , 20 % presented a heterogeneous pattern and 2 cases lacked HLA B and HLA C heavy chain but retained beta 2 microglobulin . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The frequencies of human leukocyte antigens HLA A , HLA B , HLA C , HLA DR , and HLA DQ 1 were determined in a group of 40 white British patients with oral lichen planus and compared with those of healthy controls . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
It includes a ) classical human leucocyte antigen ( HLA ) class 1 genes ( HLA A , HLA B , HLA C ) which are highly polymorphic and encode products presenting the endogenous antigenic peptides to the T cell receptors , and b ) non classical class 1 genes ( HLA E , HLA F , HLA G ) whose function is still unknown . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
One set of markers can be used to define the block that includes HLA B and HLA C , among other loci . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Although human KIRs specific for HLA C and HLA B molecules have been characterized , none have been shown to interact with HLA A . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The compiled data on the distribution of polymorphic blood groups ( ABO , Diego , Duffy , Kell Cellano , Kidd , MN , MNSs , P , Penney , Rh ( D ) , Rh Hr ) , secretion ABH antigens in saliva , HLA system ( HLA A , HLA B , HLA C , HLA DR ) , immunoglobulin ( GM 1 ) and other miscellaneous data ( phenylthiocarbamide taste , tongue rolling ) in the Caucasus are presented . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thus , in spite of the close evolutionary relationship between HLA C and HLA B , HLA C is evolving more similarly to the HLA A locus than is HLA B , further emphasizing the uniqueness of HLA B . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The presence of HLA C protein in extravillous trophoblast was investigated using a panel of Abs : L 31 is specific for heavy chains of all HLA C alleles ; Q1 / 28 reacts with all HLA class 1 products except HLA G ; HC 10 has preferential reactivity with HLA B and HLA C heavy chains . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Different types of receptors specific for groups of HLA C or HLA B alleles have been identified . ^^^ Molecular cloning of HLA C and HLA B specific receptors has revealed new members of the immunoglobulin superfamily with two or three Ig like domains , respectively , in their extracellular portion . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In the present report , we demonstrate that antibody L 31 , previously shown to react with beta 2m less ( free ) class 1 MHC heavy chains , binds to an epitope ( residues 66 68 of the alpha 1 domain alpha helix ) present on all the HLA C alleles corresponding to the accepted ( CW 1 through CW 8 ) serologic specificities , and on a few HLA B heavy chains sharing with HLA C an aromatic residue at position 67 . ^^^ Extensive IEF blot testing of HLA homozygous , EBV transformed B lymphoid cells indicates that HLA C molecules are present at significantly lower levels than HLA B polypeptides not only at cell surface , as previously demonstrated , but also in total cellular extracts . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Seventy four randomly sampled Iyers , a Brahmin population of Tamil Nadu and preachers and followers of the Advaita philosophy , living in Madurai , were studied for their HLA A , HLA B , HLA C , HLA DR , HLA DQ , C4A , C4B , and BF polymorphisms and compared with other populations . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Human natural killer ( NK ) cells express inhibitory receptors that are specific for different groups of HLA C or HLA B alleles . ^^^ Moreover , none of the HLA C or HLA B alleles that were tested exerted a protective effect . ^^^ Q66+ , but not Q 66 NK cell clones , expressed messenger RNA coding for a novel 3 Ig domain protein homologous to the HLA C ( p 58 ) and HLA B ( p 70 ) receptors . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The inter locus recombinant HLA B * 4601 has high selectivity in peptide binding and functions characteristic of HLA C . ^^^ This inter locus recombination , which brings together characteristic elements of HLA B and HLA C structure , is shown here to influence function dramatically . ^^^ For other aspects of function , presence of the small segment of HLA C derived sequence in an otherwise HLA B framework converts B * 4601 to an HLA C like molecule . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Based on the capacity of different HLA C and HLA B motifs specifically to inhibit cytotoxicity of some NK clones , three different NK cell specificities ( NK 1 , NK 2 and NK 3 ) have been described . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
CD 94 and a novel associated protein ( 94AP ) form a NK cell receptor involved in the recognition of HLA A , HLA B , and HLA C allotypes . ^^^ Here , we demonstrate that human NK cells also express C type lectin receptors that influence recognition of polymorphic HLA A , HLA B , and HLA C molecules . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Killer cell inhibitory receptors specific for HLA C and HLA B identified by direct binding and by functional transfer . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The physiological functions of the classical HLA ( human leukocyte antigen ) molecules , HLA A , HLA B and HLA C , are to present peptides to T cells and to inhibit the activity of natural killer cells . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The outermost layer of the human placenta is devoid of classical class 1 human leukocyte antigens ( HLA A , HLA B , and HLA C ) and class 2 proteins ( HLA DR , HLA DQ , and HLA DP ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Single amino acid substitutions in both a protective and a nonprotective peptide revealed the importance of residues 7 and 8 in the peptide for recognition by NK clones , thus localizing the peptide influence to a polymorphic region of the alpha helix of HLA class 1 molecules known to control discrimination among allelic variants of HLA B and HLA C by NK cells . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
To address the possibility that the HLA C gene , which is closely linked to HLA B but has been poorly defined for allo antigen specificity by the serologic method is involved in the susceptibility to Behet ' s disease , HLA C genotyping was performed for 90 Japanese Behet ' s disease patients by the PCR SSP method . ^^^ These facts suggest that the pathogenic gene of Behet ' s disease is not the HLA C gene ( HLA Cw * 14 and / or HLA Cw * 15 ) but the HLA B gene ( HLA B 51 ) itself or a non HLA gene residing in the centromeric side of the HLA B gene rather than in the telomeric side around the HLA C gene . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A roadmap for HLA A , HLA B , and HLA C peptide binding specificities . ^^^ The predictions are presented in the form of Tables and are pertinent to class 1 HLA A , HLA B , and HLA C MHC sequences , and are shown to correlate well with experiments . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Different types of receptors specific for groups of HLA C , HLA B , and , very recently , HLA A alleles have been identified . ^^^ Molecular cloning of HLA C , HLA B or HLA A specific receptors has revealed new members of the immunoglobulin superfamily with two or three Ig like domains , respectively , in their extracellular portion . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Furthermore , studies of the HLA C genotype conducted using a polymerase chain reaction sequence specific primers method have suggested that the gene involved in the pathogenesis of Behet ' s disease is not the HLA C gene but some other gene located near the HLA B gene . ^^^ We and others believe that many important genes exist in the region located between the TNF and HLA B or HLA C genes , including the MIC , PERB , and NOB genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA C antigens are expressed to the cell surface at roughly 10 % the level of HLA B or A , and their serological definition remains persistently difficult . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The alleles were in linkage disequilibrium with HLA A ( W = 0 . 58 ) , HLA B ( W = 0 . 59 ) and HLA C ( W = 0 . 55 ) in the Hutterites . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Functional studies have identified two distinct p 58 KIR , each reactive with a different group of HLA C allotypes , and distinct p 70 KIR specific for some HLA B or HLA A allotypes . ^^^ Here , we show that a soluble p 70 KIR binds to HLA B * 5101 , but not to HLA A or HLA C molecules . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Disparity for HLA A or HLA B antigens increases the risk of marrow graft rejection , but the relevance of HLA C is unknown because typing methods have not been sufficiently accurate for clinical use . ^^^ The association between HLA C disparity and graft failure remained significant even after accounting for the contribution of HLA A and / or HLA B allele disparity ( OR 4 . 0 ; 95 % CI , 1 . 1 , 15 ; likelihood ratio test P = . 03 ) . ^^^ These results show that HLA C functions as a transplantation antigen and that HLA A and HLA B allele mismatches are biologically important . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Receptors specific for groups of HLA C ( p 58 ) , HLA B ( p 70 ) and HLA A ( p 140 ) alleles belong to the Ig superfamily with two or three Ig like domains in their extracellular portion , and a long cytoplasmic tail containing ITIM motifs and associated with a non polar transmembrane portion . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Strong support for the involvement of the CD 94 C type lectin receptor complex in NK cell mediated recognition of Bw6+ HLA B , HLA A and HLA C alleles has been obtained . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Based on the capacity of different human histocompatibility leukocyte antigen ( HLA ) C and HLA B molecules to inhibit target cell lysis by NK lines and clones , three NK allospecificities have been defined : NK 1 and NK 2 cells are inhibited by different HLA C allotypes and NK 3 cells by some HLA B allotypes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
To elucidate the detailed gene organization of the human leukocyte antigen ( HLA ) class 1 region on chromosome 6 , seven contiguous cosmid genomic clones covering the 237 kb segment around the HLA B and C loci were subjected to DNA sequencing by the shotgun strategy to give a single contig of 236 , 822 bp from the MICA gene ( 58 . 2 kb centromeric of HLA B ) to 90 . 8 kb telomeric of HLA C . ^^^ This region was confirmed to contain four known genes , MICA , HLA 17 , HLA B , and HLA C , from centromere to telomere . ^^^ The two segments ( about 40 kb ) downstream of the HLA B and HLA C genes showed high sequence homology to each other , suggesting that segmental genome duplication including the major histocompatibility complex ( MHC ) class 1 gene must have occurred during the evolution of the MHC . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Furthermore , HLA C genotyping by the polymerase chain reaction sequence specific primers method suggests that the BD pathogenic gene is not the HLA C gene itself but some other gene located near the HLA B gene . ^^^ Recent studies suggest that many novel genes exist in the region between the TNF and HLA B or HLA C genes such as MIC and PERB , etc . and furthermore , many unidentified new genes have been suggested to exist in this region . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Nine of the `` new ' ' alleles come from HLA B , one comes from HLA A and one from HLA C : ten appear to be the result of recombination and one the result of point substitution . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The most frequent alleles for HLA A , HLA B and HLA C were A * 24 ( 02 , 03 ) , A * 11 ( 01 , 02 ) , A * 02 ( 01 , 03 , 05 07 , 11 ) : B * 15 ( 01 , 04 07 , 12 , 19 , 20 ) , B * 07 ( 02 05 ) , B * 51 ( 01 05 ) / B * 52 ( 011 , 012 ) ; and Cw * 07 ( 01 03 ) , Cw * 04 ( 01 , 02 ) , Cw * 08 ( 01 03 ) , respectively . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Sequence analysis of a 237 kb genomic fragment from the central region of the MHC has revealed that the HLA B and HLA C genes are contained within duplicated segments peri B ( 53 kb ) and peri C ( 48 kb ) , respectively , and separated by an intervening sequence ( IF ) of 30 kb . ^^^ The present analysis supports the hypothesis that HLA B and HLA C genes are products of an extended segmental duplication between 44 and 81 million years ago ( mya ) , and that subsequent diversification of both genomic segments occurred because of the mobility and mutation of retroelements such as Alu repeats . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The HLA A , HLA B and HLA C molecules have turned out to be highly polymorphic and functionally complex . ^^^ We have used a database of 275 HLA A , HLA B and HLA C alleles to illustrate how extensive the polymorphism is . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Using biochemical and flow cytometry approaches , the present report demonstrates that the reactivity of the murine monoclonal antibody L 31 is restricted to naturally occurring HLA C ( HLA Cw 1 through Cw 8 ) , HLA B 8 and HLA B 51 heavy chains not associated with beta 2 microglobin ( beta2m ) . ^^^ This is due to two properties of HLA C heavy chains : ( a ) they share the L 31 epitope which distinguishes them from all the HLA A and most HLA B molecules ; ( b ) they accumulate intracellularly , in a beta2m free form , in much greater amounts than most L 31 reacting HLA B heavy chains . ^^^ On the basis of this restricted reactivity , a representative panel of normal and neoplastic human tissues and cells derived from HLA B 8 B 51 individuals was selected and employed to assess the tissue distribution , surface expression and IFN gamma responsiveness of beta2m free HLA C heavy chains . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The human major histocompatibility complex ( MHC ) on chromosome 6 encodes three classical class 1 genes : human leukocyte antigen A ( HLA A ) , HLA B , and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA C genotyping by the PCR SSP method also suggests that the BD pathogenic gene is not the HLA C gene itself but other gene located near the HLA B gene . ^^^ Recently we sequenced a single contig of 236 , 822 bp from the MICA gene ( 58 . 2 kb centromeric of HLA B ) to 90 . 8 kb telomeric of HLA C and identified 8 novel genes designated NOB 1 8 ( NOB : new organization associated with HLA B ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Among the individual loci , loss rates were increased among couples matching for HLA B ( P = 0 . 019 ) , HLA C ( P = 0 . 033 ) and the complement component , C 4 ( P = 0 . 043 ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA C molecules are poorly expressed at the cell surface compared with HLA A and HLA B locus products . ^^^ We show that the HLA C 4 allele is expressed intracellularly in amounts similar to HLA A and HLA B alleles . ^^^ Our data show that the HLA C molecules tested are more selective in their peptide binding than HLA A and HLA B molecules , resulting in prolonged association with TAP and a reduced formation of intracellular HLA C / peptide complexes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Today molecular biology methods are available to define the numerous HLA alleles by genotyping [ ( 82 HLA A alleles , 174 HLA B , 38 HLA C , 166 HLA DRB 1 , 27 HLA DQB 1 , 71 HLA DPB 1 ) ( nomenclature 1996 ) ] . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Although extensive HLA A and HLA B polymorphism is evident , the true diversity of HLA C has remained hidden due to poor resolution of HLA C Ags . ^^^ Polymorphism at the HLA C locus therefore resembles that at the HLA A and HLA B loci more than previously believed , indicating that antigenic stress is driving HLA C evolution . ^^^ However , sequence conservation in the alpha helix of the first domain and a clustering of unique amino acids around the B pocket indicate that HLA C alleles respond to antigenic pressures differently than HLA A and HLA B . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
While Cw 6 is the allele most commonly thought to confer risk for psoriasis , a number of HLA B locus alleles have also been thought to be involved and , recently , in at least three studies , a specific amino acid in the HLA C heavy chain has been implicated . ^^^ They were typed for HLA B and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
An application of the method to HLA protein sequences suggests that intragenic recombination played important roles in HLA B and DPB 1 , some in HLA A and DRB 1 , and least in HLA C and DQB 1 diversity . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Extremely high levels of reticulation are observed at HLA B and HLA DPB 1 , high levels at HLA A and HLA DRB 1 , moderate levels at HLA C and HLA DQB 1 , and low levels at HLA DQA 1 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Furthermore , sequence homology between the various loci for class 1 and class 2 means that , for example , new HLA A sequences have to be compared with HLA B and HLA C primer mixes to rule out cross locus amplification . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The frequency of 30 HLA antigens ( 9 HLA A antigens , 10 HLA B antigens , 3 HLA C antigens , 7 HLA DR antigens and 1 HLA DQ antigen ) was studied by standard micro lymphocytotoxicity test in 57 patients with Eales ' disease and 50 age and sex matched normal persons as controls . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Thus far , the characterized tumor peptide antigens recognized by CTLs are all presented by classical MHC class Ia molecules [ human lymphocyte antigen A ( HLA A ) , HLA B , and HLA C in humans and H 2K , H 2D , and H 2L in mice ] . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The total discrepancy rate in 114 consecutively typed individuals for HLA A and HLA C alleles was only in favor of ARMS PCR , whereas HLA B typing was discrepant also in favor of serology . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A total of 20 HLA A locus , 35 HLA B locus and 8 HLA C locus antigens were studied . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
IFN gamma treatment of Mz 18 melanoma cells leads to up regulation of LMP2 / 7 and TAP1 / 2 , as well as to up regulation of HLA B and HLA C MHC loci alleles , but not HLA A 2 or HLA A 3 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
By applying the transmission / disequilibrium test ( TDT ) and parametric linkage analysis , we found evidence for linkage of psoriasis to HLA C , B , DR , and DQ , with HLA B and C yielding the most significant results . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In the class 1 loci , the same level of moderate codon bias is seen for HLA B , HLA C , Patr A , Patr B , and Patr C , while at HLA A the level of codon bias is lower . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Cell lines derived from Ewing ' s tumors largely lack polymorphic HLA class Ia antigens of both the HLA A and the HLA B loci but binding of monomorphic HLA antibodies indicates significant expression of HLA C locus antigens and / or HLA class Ib molecules . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Stronger linkage disequilibrium between PsV and HLA alleles was detected at HLA C and HLA B than at DRB 1 and DQB 1 . ^^^ These results identify a major PsV susceptibility locus in the immediate vicinity of , but distinct from HLA B or HLA C , and suggest that multiple disease alleles have arisen during human evolution . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In this paper we analyze the two regions of about 385 kb and confirm , giving a new line of evidence , that the following two pairs of the genomic segments were duplicated in evolution : ( 1 ) a 43 kb genomic segment including the HLA B gene showing the highest polymorphism among the classical HLA class 1 loci ( class Ia ) and a 40 kb segment including the HLA C locus showing the lowest polymorphism and ( 2 ) a 52 kb segment including the MIC ( MHC class 1 chain related gene ) B and a 35 kb segment including MICA . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HERV L and HERV 1 are located between the duplicated genes PERB11 . 2 ( MICB ) and PERB11 . 1 ( MICA ) , and HLA B and HLA C , respectively , whereas HERV K 91 and HARLEQUIN are located telomeric of HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
With this latter method , a low overall HLA expression was detected in 26 tumor cell explants and a complete , generalized HLA A , HLA B , HLA C loss in the remaining 4 cases . ^^^ This alternative model of tumor host interaction better fits the available models of tumor cell recognition by CTLs and natural killer cells bearing activatory and inhibitory receptors for HLA A , HLA B , HLA C molecules . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The extended HLA typing showed that only one out of the six pairs with a different HLA A locus had additional mismatches at HLA C and DQB 1 loci , whereas all the remaining 8 pairs , which already differed at HLA B and / or DRB 1 loci after conventional typing , had additional HLA C and / or DQB 1 mismatches ( p = 0 . 002 ) . ^^^ INTERPRETATION AND CONCLUSIONS : The present data show that additional mismatched HLA C and / or DQB 1 antigens are significantly more frequent in pairs which after conventional HLA typing differed at HLA B and / or DRB 1 loci , than in those showing one HLA A mismatch . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In comparison to mismatching for HLA B locus , mismatching for either HLA DRB 1 or A resulted in a lower odds ratio for HLA C disparity . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We hypothesise that insertion of an extra cytosine into the cytosine island between nucleotide positions 621 627 is likely to recur not only in other HLA A alleles but also in HLA B and even HLA C alleles . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Of particular relevance to psoriasis is that these NKRs recognize various class 1 alleles including those typically inherited by psoriatic family members such as HLA C and HLA B allotypes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In contrast , the beta block has two major duplications containing the genes HLA B and HLA C , and MICA ( PERB11 . 1 ) and MICB ( PERB11 . 2 ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The remaining classical HLA loci ( HLA B and HLA C ) should be typed when reliable DNA based methods become available . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We present evidence that HIV 1 selectively downregulates HLA A and HLA B but does not significantly affect HLA C or HLA E . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The percentage of pairs that were allele matched was as follows ; HLA A = 91 % ( n = 80 ) , HLA B = 94 % ( n = 80 ) , HLA C = 78 % ( n = 80 ) , HLA DRB 1 = 96 % ( n = 122 ) , HLA DQA 1 = 99 % ( n = 80 ) , HLA DQB 1 = 92 % ( n = 122 ) . 92 recipient / donor pairs with informative clinical data were available for analysis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
It is shown that IFN gamma induced MHC class 1 transactivation through the ISRE of HLA A , HLA B , HLA C , and HLA F . ^^^ Sp 1 was shown to bind to the CG rich sequences in the ISRE regions of HLA B , HLA C , and HLA G . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Using the transmission disequilibrium test , we found significant evidence of linkage and allelic association across an interval defined by the markers tn 62 ( p = 1 . 0 10 10 ( 7 ) ) , HLA B ( p = 4 . 0 10 10 ( 7 ) ) , and HLA C ( p = 2 . 7 10 10 ( 9 ) ) , a region encompassed within a 285 kb genomic DNA fragment . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
There appeared to be a region of maximal susceptibility extending from HSP 70 ( in class 3 ) past HLA B and HLA C at least 600 kb telomerically into the class 1 region , which is now being mapped in detail . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The probability of HLA C matching between patient and unrelated donor at the molecular level : estimations based on the linkage disequilibrium between DNA typed HLA B and HLA C alleles . ^^^ In this study , we determine the LD between HLA B and C alleles and estimate the probability of molecular HLA C matching between unrelated individuals who match for both HLA B alleles . ^^^ The probability of HLA C matching for specific HLA B allele was estimated from contingency table generated from the HLA B and C haplotypes . ^^^ RESULTS : HLA C was found to exist in LD with HLA A and B , as well as DRB 1 , loci ; however , it was strongest between HLA B and C loci . ^^^ The overall estimated probability of HLA C matching between unrelated individuals that match for both HLA B alleles is 42 . 25 % . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Fetal cytotrophoblasts , which are in direct contact with the maternal immune system in the uterus during pregnancy , do not express HLA A and HLA B , but express the nonclassical class 1 HLA G and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
JY and Pala lymphoblastoid B cells express more HLA A than HLA B mRNAs and little HLA C mRNA . ^^^ Raji Burkitt lymphoma and HeLa carcinoma cells express approximately equal amounts of HLA A and HLA C mRNAs but less HLA B mRNA . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Beta block matching was highly correlated with matching for exons 2 and 3 of HLA B but less so for HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Several highly polymorphic sequences are present in the beta block of the MHC , especially HLA B , HLA C , PERB11 . 1 ( MICA ) , and PERB11 . 2 ( MICB ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Diversity in 23 Patr A , 32 Patr B , and 18 Patr C alleles obtained from study of 48 chimpanzees was compared to diversity in 66 HLA A , 149 HLA B , and 41 HLA C alleles obtained from a study of over 1 million humans . ^^^ Considering the numbers of lineages , families , and alleles , Patr B and Patr C have greater diversity than the HLA B and HLA C , respectively . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The results demonstrated 9 % misassignments of HLA A antigens by serology , 11 % of HLA B and 39 % of HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA A , HLA B and HLA C . ^^^ In damaged cells , such as virally infected or tumour cells , down regulation of HLA A , HLA B and HLA C production or inhibition of TAP prevents stabilization of HLA E by the leader peptide . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA A , HLA B and HLA C polymorphism in the Slovak population . ^^^ The frequencies of HLA A alleles ranged from 0 . 00 for A * 4301 to 0 . 2798 for A * 0201 22 ; the frequencies of HLA B alleles ranged from 0 . 00 for B 4601 , B * 4801 3 , B * 5901 , B * 7301 , and B * 8101 to 0 . 1101 for B * 4402 10 , and those of HLA C alleles from 0 . 00 for Cw * 1301 and Cw * 1402 3 to 0 . 2661 for Cw 0701 10 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Polymorphism of classical HLA A , HLA B , HLA C , HLA DR , and HLA DQ genes differs greatly among populations , both in frequencies and in the presence of alleles and haplotypes particular to population groups , making these genes powerful tools for the study of origins of populations and their degree of admixture . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Transfection of CIITA in JEG 3 cells also upregulated functional HLA B and HLA C expression . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Nevertheless , a more accurate functional analysis demonstrated not only that HSV infection downregulated the expression of HLA A and HLA B and did not modify the expression of HLA C , but also that NK cell clones expressing the `` activating ' ' form of the anti HLA C NK cell receptor were more cytolytic than other clones . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We examined a sample of 95 type 1 psoriasis patients and 104 Spanish matched controls to investigate whether HLA Cw * 0602 or other closely related class 1 loci , such as HLA B and MICA ( which are centromeric to HLA C ) , or corneodesmosin gene and octamer transcription factor 3 genes ( which are telomeric to HLA C ) , might play a part in disease development . ^^^ DNA samples were genotyped by polymerase chain reaction / sequence specific primers ( HLA C ) , polymerase chain reaction / sequence specific primers ( HLA B ) , radioactive polymerase chain reaction ( MICA TM polymorphism in the transmembrane region ) , and polymerase chain reaction / restriction fragment length polymorphism ( protein S and octamer transcription factor 3 ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Single locus specific amplification and hybridization with sets of 67 SSOP for HLA A , 99 for HLA B and 57 for HLA C allowed us to identify unequivocally the majority of A , B , C alleles at HR level . ^^^ In these samples , 63 HLA A , 170 HLA B and 40 HLA C alleles were observed . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Combinations of 6 HLA A , 6 HLA B , 5 HLA C , 1 Bf , 3 C4AB , 3 DQA 1 , 3DQB1 and 2 DPA 1 and 2 DPB 1 alleles present in this population originate 17 different haplotypes , 3 of which represent 63 % of the haplotypic constitution of the tribe . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Comparison of the intron sequence of B * 7301 with other HLA B and HLA C alleles revealed several remarkable features . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Among the different mechanisms , there has been noted a selective expression of HLA molecules on trophoblast cells : the absence of HLA class 2 and of polymorphic HLA A and HLA B expression but presence of both non polymorphic HLA G and HLA E class Ib as well as of HLA C class Ia . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The three human leukocyte antigen ( HLA ) class 1 antigens , HLA A , HLA B and HLA C , play important roles in the elimination of transformed cells by cytotoxic T cells . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The clonal distribution of these inhibitory receptors permits NK cell recognition of target cells that have lost expression of a single HLA B or HLA C allotype . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
PURPOSE : An association between expression of > or = two of five HLA class 1 antigens ( HLA A 2 , HLA A 28 , HLA B 44 , HLA B 45 , and HLA C 3 ; collectively called M 5 ) and response to an allogeneic melanoma vaccine ( Melacine ; Corixa Corporation , Seattle , WA ) has been described in stage 4 melanoma . ^^^ PATIENTS AND METHODS : We performed class 1 ( HLA A , HLA B , and HLA C ) serotyping on patients enrolled onto Southwest Oncology Group Trial 9035 , a randomized , observation controlled , phase 3 trial of adjuvant Melacine . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
RESULTS : The average CCI ( 1 hour ) and CCI ( 24 hours ) in all patients were 20 . 0 and 12 . 8 for HLA A , HLA B , and HLA C compatible transfusions and were 1 . 4 and 1 . 2 for HLA A and HLA B compatible but HLA C incompatible transfusions , respectively ( p < 0 . 001 ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
This algorithm is based on the concept that immunogenic epitopes are represented by amino acid triplets on exposed parts of protein sequences of human leukocyte antigen chains ( HLA A , HLA B , and HLA C ) accessible to alloantibodies . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
As the result of these events , HLA A and / or HLA B allele mismatch reduced overall survival remarkably in both standard risk and high risk leukemia cases , whereas the HLA C mismatch or HLA class 2 ( DRB 1 and / or DQB 1 ) mismatch did not . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Novel HLA B alleles formed by an inter locus recombination with HLA C , HLA B * 0713 and B * 6702 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
CD4+ and CD8+ T cells induced follicular expression of intercellular adhesion molecule 1 ( CD 54 ) , HLA DR , and HLA A , HLA B , and HLA C after injection into scalp grafts . ^^^ It is now necessary to look for HLA A , HLA B , and HLA C associations with alopecia areata . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Rabbit antibodies were raised against both long and short peptides derived from exon 7 sequences of human leukocyte antigen ( HLA ) class 1 alpha chains ; anti A / B against a 13 mer shared by most HLA A alpha and HLA B alpha chains , anti C against a 15 mer characteristic of HLA C alpha chains , anti ACT against a 6 mer specific to HLA A alpha chains , and anti CCT against a 5 mer specific to HLA C alpha chains . ^^^ Thus , anti A / B and anti C bound better to HLA B and HLA E rather than to HLA A and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In contrast to the KIR2D : HLA C interaction , little is known of KIR3DL1 ' s interaction with HLA B or the role of D 0 , the domain not present in KIR2D . ^^^ In contrast point mutations in the D 1 and D 2 domains of KIR3DL1 , made from knowledge of KIR2D : HLA C interactions , disrupted binding to Bw 4 ( + ) HLA B . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
For the locus HLA B were B 35 and B 38 respectively and for the locus HLA C the most common gen was C 4 , and C 3 for the rest of the population . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Characterization of ligands and motifs remains roughly the same at the HLA B locus while the peptides of the HLA C locus tend to be less characterized . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
On the other hand , HLA B and HLA C down regulation in iDC was not sufficient to induce cytotoxicity in NK cells expressing KIR3DL1 or KIR2DL . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The class Ia molecules include the gene products of HLA A , HLA B , and HLA C loci and are characterized by broad tissue expression and by a high degree of polymorphism . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The intron 4 sequences were determined for 27 HLA A , 81 HLA B and 30 HLA C alleles by allele specific sequencing , using primers located in adjacent exons and introns . ^^^ Remarkable was the deletion of 20 nucleotides in all HLA A and B alleles compared with HLA C , whereas the HLA A alleles showed an insertion of one nucleotide and a deletion of three nucleotides compared with HLA B and C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
METHODS : We prospectively measured the frequency of panel reactive HLA class 1 ( HLA A , HLA B , and HLA C ) and class 2 ( HLA DR / DQ ) alloantibodies in 14 children ( age 8 . 5 + / 7 . 9 years ) receiving decellularized , cryopreserved allografts , including 6 undergoing allograft patch insertion and 8 with a valved pulmonary allograft . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Roles of HLA B , HLA C and HLA DPA 1 incompatibilities in the outcome of unrelated stem cell transplantation . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The evolutionary mode of these genes is similar to that of classic HLA genes , HLA A , HLA B , and HLA C , in terms of their recent origin and rarity of pseudogenes , and differs from them with respect to the degree of gene duplications . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Overall , 66 . 7 % of the patients had at least one HLA C mismatch with their donors ; 36 . 9 % of those matched for HLA B and 85 . 5 % of those mismatched for HLA B ( P < 0 . 0001 ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Several HLA B alleles and all HLA C and E alleles are likely to be insensitive to US 2 mediated degradation . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
This expression may be relevant in tumor cells that have lost the capacity to interact with NK inhibitory receptors namely , those tumor cells with no HLA B or HLA C expression . ^^^ Most published studies have not analyzed these possibilities and do not provide information about the complete HLA A , HLA B , or HLA C molecule profiles of the tumors studied . ^^^ In contrast , HLA E has been reported to be expressed in some tumor cell lines with very low HLA A , HLA B , and HLA C expression , suggesting that HLA E may indeed , in some cases , play a role by inhibiting NK lysis of cells that otherwise would be destroyed by NK cells . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Unlike HLA A and HLA B , few peptide epitope motifs have been reported for HLA C molecules . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The aim of this study is to define a reliable reckoning of gene frequencies and six locus haplotypic frequencies of HLA A , HLA B , HLA C , HLA DRB 1 , HLA DQA 1 , HLA DQB 1 and HLA DPB 1 in the Tunisian population . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Moreover , we determined that HPV 16 E 5 downregulates surface expression of HLA A and HLA B , which present viral peptides to MHC class 1 restricted cytotoxic T lymphocytes ( CTLs ) , but not the natural killer ( NK ) cell inhibitory ligands HLA C and HLA E . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
PATIENTS AND METHOD : We performed HLA A , HLA B , HLA C , and HLA D typing in 83 patients with sarcoidosis and in 250 healthy controls using a microlymphocytotoxicity method to investigate genetic susceptibility to the disease . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In class 1 loci , three HLA A allelic groups ( HLA A * 24 , HLA A * 34 and HLA A * 11 ) , seven HLA B alleles or allelic groups ( HLA B * 1506 , HLA B * 5602 , HLA B * 13 , HLA B * 5601 , HLA B * 4001 , HLA B * 4002 and HLA B * 2704 ) and four HLA C alleles or allelic groups ( HLA Cw * 04 , HLA Cw * 01 , HLA Cw * 0702 and HLA Cw * 15 ) constituted more than 90 % of the alleles observed . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We observed a significant association between particular combinations of KIR epitopes expressed by HLA B / C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA B and HLA C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and / or other infectious pathogens . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
This study further confirms that HLA C locus is at least as polymorphic as HLA A and HLA B . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The highly polymorphic gene products of the classical MHC class 1 genes in humans ( HLA A , HLA B , and HLA C ) play a critical role in the immune defense against intracellular infections . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The human major histocompatibility complex class 1 chain related ( MIC ) genes are members of a multicopy family showing similarity to the classical HLA A , HLA B , and HLA C genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In this study , molecular genotyping was performed at the HLA B and HLA C loci for 283 multiplex Caucasian families , previously typed for HLA A and the class 2 loci . ^^^ Linkage disequilibrium coefficients were calculated for HLA B HLA C haplotypes and for class 1 lass 2 haplotypes . ^^^ As with previous results for HLA A , HLA B and HLA C are associated with age at T1D onset ( mean 11 . 6 + / 0 . 3 years ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A total of 20 HLA A , 43 HLA B , 21 HLA C , 31 HLA DRB 1 , and 14 HLA DQB 1 alleles were identified . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Paired normal and cancer genomic DNA was analyzed with DNA typing trays , including 57 subtypes of HLA A , 120 subtypes of HLA B , and 60 subtypes of HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In this study , we present the validation of 16 of those SALs by flow cytometry against a panel of 84 human HLA specific monoclonal antibodies ( 30 HLA A [ 8 IgG / 22 IgM ] , 45 HLA B [ 18 IgG / 27 IgM ] , 6 HLA A , B [ 3 IgG / 3 IgM ] , and 3 HLA C [ all IgM ] ) developed in our laboratory . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The proportion of variations explained by pathogen richness is higher for the HLA B gene than for the HLA A and HLA C genes . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Twenty two human major histocompatibility complex ( MHC ) region microsatellite ( Msat ) markers were studied for diversity and linkage disequilibrium ( LD ) with HLA loci in hematopoietic cell transplant recipients and their HLA A , HLA B , HLA C , HLA DRB 1 , and HLA DQB 1 allele matched unrelated donors . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
To demonstrate the sensitivity of our approach we characterized peptides binding to HLA C molecules that are usually expressed at the cell surface at approximately only 10 % the levels of HLA A or HLA B . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
However , locus specific down regulation in leukaemia has not been widely investigated , although majority of cytotoxic T lymphocyte ( CTL ) responses are modulated by HLA A and HLA B , whereas expression of only HLA C is unable to block natural killer ( NK ) cell mediated cytotolysis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Through the analyses of two and three loci haplotypes of HLA A , HLA B , and HLA C loci , 11 HLA A B Cw haplotypes , 19 HLA A B haplotypes , 18 HLA A Cw haplotypes , and 24 HLA B Cw haplotypes with the frequencies of higher than 0 . 01 were revealed . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Tumour transformation is frequently associated with low classical HLA class 1 molecules expression , namely HLA A , HLA B , and HLA C . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In order to detect the HLA alleles with a frequency of more than 0 . 1 % in the Japanese population , we created 48 oligonucleotide probes for the HLA A locus , 61 for HLA B , 34 for HLA C , and 51 for HLA DRB 1 . ^^^ Overall , the genotyping method exhibited an accuracy of 85 . 91 % for HLA A , 85 . 03 % for HLA B , 97 . 32 % for HLA C , and 90 . 67 % for HLA DRB 1 using 150 control samples , and 100 % for HLA A and C , 99 . 90 % for HLA B , and 99 . 95 % for HLA DRB 1 in 1 , 018 Japanese samples . ^^^ It takes only approximately 5 h from DNA extraction to the definition of HLA four digit alleles at the HLA A , HLA B , HLA C , and HLA DRB 1 loci for 96 samples when handled by a single typist . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Polymorphic genes and markers from HLA B ( centromeric to HLA C ) to the corneodesmosin ( CDSN ) gene ( telomeric to HLA C ) were genotyped in order to determine their contribution to the susceptibility to psoriasis . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
For this purpose , HLA A and HLA B serotyping and HLA C , HLA DRB 1 , and HLA DQB 1 genotyping by polymerase chain reactions using sequence specific oligonucleotide ( PCR SSO ) and sequence specific primer ( PCR SSP ) were performed in 174 melanoma patients and 227 ethnically matched controls . ^^^ In conclusion , although an association with HLA A , HLA B , HLA DRB 1 , or HLA DQB 1 was not demonstrated , the study of the HLA C locus revealed that the analysis of the dimorphism at position 80 in the alpha 1 helix may help to evaluate the risk and prognosis of melanoma in our population . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
METHODS : The method of choice was polymerase chain reaction with sequence specific primers ( PCR SSP ) using low resolution typing kits , with determination of the alleles class 1 ( HLA A , HLA B and HLA C ) and class 2 ( HLA DRB 1 , DRB 3 , DRB 4 , DRB 5 and DQB 1 ) performed in 30 Afro Brazilian PR diagnosed patients and 45 healthy individuals as the control group ( PR C ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Distinct clinical differences between HLA Cw * 0602 positive and negative psoriasis patients an analysis of 1019 HLA C and HLA B typed patients . ^^^ The patients were typed for HLA C and HLA B . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We investigated the genetic diversity of HLA A , HLA B and HLA C alleles in remote populations of Cameroon . ^^^ Subjects from seven small , isolated , indigenous populations ( N = 274 ) in the rainforest of southern Cameroon were typed for HLA A , HLA B and HLA C alleles using a polymerase chain reaction / sequence specific oligonucleotide probe assay and sequence analysis . ^^^ Multiple alleles of the HLA A ( N = 28 ) , HLA B ( N = 41 ) and HLA C ( N = 21 ) loci were identified , of which A * 2301 [ allele frequency ( AF ) = 12 . 8 % ] , B * 5802 ( AF = 10 . 9 % ) and Cw * 0401 ( AF = 16 . 6 % ) were the most frequent individual alleles and A * 02 ( AF = 19 . 0 % ) , B * 58 ( AF = 15 . 9 % ) and Cw * 07 ( AF = 22 . 4 % ) the most common serologically defined groups of alleles . ^^^ Heterozygosity values of 0 . 89 , 0 . 92 and 0 . 89 were determined for HLA A , HLA B and HLA C , respectively . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Immunologists are now beginning to understand the various factors that contribute to the maternal immune tolerance and , in particular , the role of classic ( human leukocyte antigen [ HLA ] A , HLA B , HLA C , and HLA D ) and non classic ( HLA E , HLA F , and HLA G ) major histocompatability antigens in this process . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The peripheral blood leukocyte derived mRNA of six captive animals rescued from a stranding incident on the French frigate shoals in the Hawaiian archipelago was used to characterize genes in the monk seal class 1 MHC gene family , from which techniques for genotyping the broader population were designed using degenerate primers designed for the three major established human MHC class 1 loci ( HLA A , HLA B , and HLA C ) , and by sequencing multiple clones , six unique full length classical MHC class 1 gene transcripts were identified among the six animals , three of which were only found in single individuals . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
BACKGROUND : To understand whether the association between Epstein Barr Virus ( EBV ) and gastric cancer ( GC ) has any role in loss of surface expression of human lymphocyte antigen ( HLA ) class 1 , the authors analyzed locus specific transcriptional expression of HLA A , HLA B , HLA C , and HLA E along with other HLA associated molecules ( beta 2 microglobulin [ beta2M ] , cellular latent membrane protein [ LMP ] , and transporter associated with antigen presentation [ TAP ] ) in EBV associated , primary GC ( EBVaGC ) and EBV negative GC ( EBVnGC ) tissues . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA B and HLA C alleles were resolved to four digits by a combination of molecular methods , and their respective associations with outcomes of HIV 1 infection were analyzed by statistical procedures appropriate for continuous or categorical data . ^^^ Overall , B58s alleles , individually or as part of an HLA B HLA C haplotype , appeared to have a distinctive impact on HIV 1 infection among native Africans . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Low cost , simultaneous , single sequence genotyping of the HLA A , HLA B and HLA C loci . ^^^ Genotypes were assigned by comparing each sequence to a database of 307 HLA A , 563 HLA B and 166 HLA C alleles . ^^^ Unequivocal , 4 digit allele assignments were made for 40 of 130 HLA A genes , 82 of 130 HLA B genes and 97 of 130 HLA C genes from 21 European , 20 Tongan and 24 Niuean subjects . ^^^ All known alternative interpretations of ambiguous genotypes were identified , and seven HLA B and two HLA C ambiguities were resolved by reading the out of phase exon 2 sequence that followed an indel in intron 2 . ^^^ In European subjects , the repertoire of HLA B / HLA C haplotypes was almost identical to previously published data . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Humans express three highly polymorphic classical MHC class 1 genes ( HLA A , HLA B and HLA C ) . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
We have analysed fifteen classical 21 hydroxylase deficiency families from throughout Southern Ireland and report the serologically defined HLA A , HLA B , HLA Cw , HLA DR , C4A and C4B polymorphisms that characterize the inferred disease haplotypes . ^^^ The results obtained indicate that disease haplotypes are characterized by a high frequency ( 33 % ) of CYP21B gene deletion and 8 out of 10 such deletion haplotypes are represented by the extended haplotype HLA DR 1 , C4BQo , C4A3 , HLA B 40 ( w 60 ) , HLA Cw 3 , HLA A 3 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In all cases we assessed 11 HLA A , 16 HLA B and 5 HLA Cw antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
There exists no absolute binding between the antigens HLA Cw 2 , Cw 3 and Cw 4 , on the one hand , and HLA B 27 , HLA B 15 and HLA Bw 35 , on the other hand . ^^^ Even if 91 % of human beings with HLA Cw 4 will simultaneously have the antigen HLA Bw 35 , another antigen as HLA B 27 or HLA B 15 can be identified in approximately 55 % of individuals with HLA Cw 2 and Cw 3 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Six additional HLA Cw alleles were identified by unusual restriction patterns and confirmed by sequencing ; this observation suggests the presence of another family of allele sharing clusters in the HLA B locus . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA Cw antigen detection by CMC correlated with HLA B ( p < 0 . 01 ) , suggesting that down regulation and sensitivity to IFN gamma are shared by the two loci . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
OBJECTIVE To determine whether women with rheumatoid arthritis ( RA ) had differences in obstetric and gynaecological histories when compared with sisters without RA ( controls ) METHODS Ninety eight RA discordant sister pairs , 36 of whom were identical for histocompatibility locus antigen ( HLA A , HLA B , and HLA Cw ) types , were asked to recall their age of menarche , duration of use of contraceptive pill , pregnancy history , and age of menopause . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A novel method for simultaneous high resolution identification of HLA A , HLA B , and HLA Cw alleles . ^^^ Unique identification patterns for 201 known HLA A , HLA B , and HLA Cw alleles were generated by the use of only 40 probes , which were targeted at these common motifs . ^^^ To validate the method , we have used locus specific primers to amplify exons 2 and 3 of HLA A , HLA B , and HLA Cw loci from 22 heterozygous and 41 homozygous cell lines . ^^^ In all cases , the allelic products could be separated and 81 different class 1 alleles , 33 HLA A , 30 HLA B , and 18 HLA Cw , were identified according to the predicted probe hybridization patterns . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The KIRs of the p58 / p50 family have two immunoglobulin domains and are ligands for HLA Cw antigens , whereas the p70 / p70 delta family has three immunoglobulin domains and comprises ligands for HLA B antigens and possibly some HLA A antigens . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA A , B and Cw alleles were determined using the polymerase chain reaction amplification refractory mutation system ( PCR ARMS ) . 12 HLA A , 20 HLA B and 14 HLA Cw alleles were found . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
All patients with C 2 deficiency carrying the haplotype [ HLA B 18 , S 042 , DR 2 ] were associated with HLA Cw * 1203 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The KIR2DL ( inhibiting ) and KIR2DS ( activating ) molecules recognize HLA Cw antigens , while the KIR3DL ( inhibiting ) and KIR3DS ( activating ) molecules interact with HLA B antigens with the Bw 4 epitope . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Frequency of HLA A , HLA B and HLA Cw antigens in the Slovak population ] . ^^^ The highest frequency was observed for the antigens HLA A 2 , A 1 ; HLA B 12 , B 35 , and HLA Cw 8 . ^^^ The least frequent antigens were HLA A 34 , A 36 , HLA B 58 , B 67 , B 70 , B 77 , and HLA Cw 8 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A total of 20 HLA A alleles , 16 HLA Cw alleles , 38 HLA B alleles , 27 HLA DRB 1 alleles , 15 HLA DQB 1 alleles and 12 HLA DPB 1 alleles were detected . ^^^ Among 19 HLA B alleles with the high allele frequencies ( above 0 . 007 ) , 9 HLA B alleles , B * 0702 , B * 1301 , B * 3701 , B * 3901 , B * 4006 , B * 4403 , B * 5201 , B * 5901 and B * 6701 were found to be tightly associated with single HLA Cw alleles . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A large variety of three locus ( MICA HLA B HLA Cw ) and six locus ( HLA DQB 1 HLA DRB 1 MICA HLA B HLA Cw HLA A ) haplotypes were recognized in the northeastern Thai population . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
METHODS : DNA samples from 81 Spanish patients with PsA and 110 healthy controls were examined by polymerase chain reaction ( PCR ) sequence specific primers to type HLA Cw and HLA DRB 1 , PCR sequence specific oligonucleotides to determine HLA B , and PCR restriction fragment length polymorphism for tumor necrosis factor alpha promoter polymorphisms at positions 238 and 308 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
Statistically significant findings are as follows ( P < 0 . 05 ) : increased HLA B 51 and decreased HLA B 35 frequency in patients with thrombophlebitis , increased HLA A 29 and decreased HLA Bw 6 frequency in patients with ocular involvement , decreased HLA Cw 2 frequency in patients with erythema nodosum , and decreased HLA Cw 7 frequency in patients with genital ulceration . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The SBT method is the only allelic typing technique used in our laboratory ( to date , 742 HLA A * , 802 HLA B * and 615 HLA Cw * alleles have been sequenced ) and our successful participation in the national and international quality controls of 4 years ago testifies to the accuracy of the results . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
HLA Cw * 0409N is associated with HLA A * 2301 and HLA B * 4403 carrying haplotypes . ^^^ The associations of HLA B * 4402 and HLA B * 4403 with alleles of HLA A and HLA Cw were investigated in panels of HLA B * 4403 and HLA B * 4402 homozygous individuals and in selected individuals carrying HLA Cw * 04 and HLA B * 4403 . ^^^ Our findings demonstrate the first example of three different HLA Cw determined subtypes of a common or CEH carrying a shared HLA B allele , in this case HLA B * 4403 . . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
RESULTS : We identified 62 distinct alleles of HLA A , HLA Cw , and HLA B and 49 distinct alleles of HLA DRB 1 and HLA DQB 1 in patients with HAU , asymptomatic HTLV 1 carriers , and healthy controls . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
In this study , we have retrospectively analyzed 44 donor recipient pairs from the Australian Bone Marrow Donor Registry Repository with respect to matching of HLA B and HLA Cw by sequence based typing and MICA and MICB by polymerase chain reaction sequence specific primer and MHC beta block matching and correlated these results with survival . ^^^ Beta block matching was correlated with MIC matching ( p < 0 . 005 ) and with HLA B and HLA Cw matching . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
The existence of a psoriasis susceptibility locus , PSORS 1 ( HUGO / GDB approved symbol ) , in or near the HLA region of chromosome 6 is strongly supported by a lod score analysis of HLA B and psoriasis in 97 families from 16 published datasets . ^^^ The recombination fraction between PSORS 1 and HLA B is estimated to be at or near 0 . 00 , with a maximum two point lod score of 23 . 7 , assuming a dominant mode of inheritance with low ( 20 % ) penetrance at the PSORS 1 locus . ^^^ We also conclude that the HLA B 17 allele , which is strongly associated with psoriasis , is unlikely itself to contribute directly to psoriasis susceptibility ; rather , the HLA B locus is probably tightly linked to the PSORS 1 locus . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
A variety of genes and regions from a 238 kb interval extending from HLA B to corneodesmosin ( CDSN ) have been proposed to harbor PSORS 1 . ^^^
Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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Interacting proteins: P30504 and P01889	Pubmed	SVM Score :0.0
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